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### Variant Calling

This APP developed for germline and somatic short variant discovery (SNVs + Indels).

**Accepted Data**
**Accepted data**
* TN matched WES for somatic variant calling
* TN matched WGS for somatic variant calling
* Normal-only WES for germline variant calling
@@ -9,33 +10,19 @@ This APP developed for germline and somatic short variant discovery (SNVs + Inde

The datatype is judged by whether the bed file is set (i.e. the `regions` in inputs).

---

**Supported Callers**

* The fields corresponding to these callers include `haplotyper`, `tnseq`, `tnscope`, `varscan`.
* All callers are <u>**not activated by default**</u>, which means the default setting is `false`.
* You need to manually set the caller to `true` in the submitted sample.csv.

<u>***Germline***</u>
* Haplotyper

<u>***Somatic***</u>
* TNseq (TNhaplotyper2)
* TNscope
* VarScan

---
**Supported variant callers and annotation tools**

**Annotation Tools**
* The fields corresponding to two tools include `annovar`, `vep`.
* All tools are <u>**not activated by default**</u>, which means the default setting is `false`.
* You need to manually set the caller to `true` in the submitted sample.csv.
* Variant calling:
* * `haplotyper` (germline)
* * `tnseq`, `tnscope`, `varscan` (somatic)
* Annotation: `annovar`, `vep`.
* The above tools are <u>**not activated by default**</u>, which means the default setting is `false`. You need to manually set the caller to `true` in the submitted sample.csv.

### New Releases
* Two annotation tools have been added.
* TNhaplotyper, named as TNseq in `v0.1.0`, has beed substituted by TNhaplotyper2.
* The `corealigner` step has been removed.
* The `vcf2maf` step has been removed. Thus, the final output is the annotated `VCF`.
* Some parameters' details have been changed, such as the `interval_list` has turned into `interval`.

### Getting Started

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