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  1. # Strelka2
  2. You don't need to tune the parameters of strelka. It bases on [trained models](<https://github.com/Illumina/strelka/blob/v2.9.x/docs/userGuide/trainingGermlineEmpiricalScore.md>), you may train new models to improve performance.
  3. Two steps:
  4. 1. Generate the configuration
  5. ```bash
  6. ```
  7. 2. Run Strelka
  8. ```bash
  9. ```
  10. ##### Per sample run time
  11. 4h30min
  12. ##### Reference
  13. 1. Strelka User Guide <https://github.com/Illumina/strelka/blob/v2.9.x/docs/userGuide/README.md>
  14. 2. Strelka paper <https://www.nature.com/articles/s41592-018-0051-x>