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rename vcf gz

master
LUYAO REN 5 jaren geleden
bovenliggende
commit
74953ff632
4 gewijzigde bestanden met toevoegingen van 71 en 15 verwijderingen
  1. +1
    -0
      inputs
  2. +40
    -0
      tasks/VCFrename.wdl
  3. +9
    -9
      tasks/merge.wdl
  4. +21
    -6
      workflow.wdl

+ 1
- 0
inputs Bestand weergeven

@@ -1,5 +1,6 @@
{
"{{ project_name }}.fasta": "GRCh38.d1.vd1.fa",
"{{ project_name }}.VCFrename.docker": "registry-vpc.cn-shanghai.aliyuncs.com/pgx-docker-registry/rtg-tools:latest",
"{{ project_name }}.sister.docker": "registry-vpc.cn-shanghai.aliyuncs.com/pgx-docker-registry/vbt:v1.1",
"{{ project_name }}.mendelian.docker": "registry-vpc.cn-shanghai.aliyuncs.com/pgx-docker-registry/vbt:v1.1",
"{{ project_name }}.disk_size": "150",

+ 40
- 0
tasks/VCFrename.wdl Bestand weergeven

@@ -0,0 +1,40 @@
task VCFrename {
File mother_vcf_gz
File father_vcf_gz
File twins_vcf_gz
File mother_vcf_idx
File father_vcf_idx
File twins_vcf_idx
String mother_name
String father_name
String family_name
String docker
String cluster_config
String disk_size
command <<<
echo "MOTHER ${mother_name}" > mother_rename.txt
rtg vcfannotate -i ${mother_vcf_gz} -o ${mother_name}.rename.vcf.gz --relabel=mother_rename.txt

echo "FATHER ${father_name}" > father_rename.txt
rtg vcfannotate -i ${father_vcf_gz} -o ${father_name}.rename.vcf.gz --relabel=father_rename.txt

echo "CHILD ${family_name}" > child_rename.txt
rtg vcfannotate -i ${twins_vcf_gz} -o ${family_name}.twins.rename.vcf.gz --relabel=child_rename.txt
>>>

runtime {
docker:docker
cluster: cluster_config
systemDisk: "cloud_ssd 40"
dataDisk: "cloud_ssd " + disk_size + " /cromwell_root/"
}
output {
File rename_mother_vcf_gz = "${mother_name}.rename.vcf.gz"
File rename_father_vcf_gz = "${father_name}.rename.vcf.gz"
File rename_twins_vcf_gz = "${family_name}.twins.rename.vcf.gz"
File rename_mother_vcf_idx = "${mother_name}.rename.vcf.gz.tbi"
File rename_father_vcf_idx = "${father_name}.rename.vcf.gz.tbi"
File rename_twins_vcf_idx = "${family_name}.twins.rename.vcf.gz.tbi"
}
}

+ 9
- 9
tasks/merge.wdl Bestand weergeven

@@ -1,21 +1,21 @@
task merge {
Array[File] mother_vcf_gz
Array[File] mother_vcf_idx
Array[File] father_vcf_gz
Array[File] father_vcf_idx
Array[File] twins_vcf_gz
Array[File] twins_vcf_idx
Array[File] rename_mother_vcf_gz
Array[File] rename_mother_vcf_idx
Array[File] rename_father_vcf_gz
Array[File] rename_father_vcf_idx
Array[File] rename_twins_vcf_gz
Array[File] rename_twins_vcf_idx
String mapper_caller
String docker
String cluster_config
String disk_size
command <<<
rtg vcfmerge --force-merge-all --no-gzip -o LCL8.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " mother_vcf_gz}
rtg vcfmerge --force-merge-all --no-gzip -o LCL8.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " rename_mother_vcf_gz}

rtg vcfmerge --force-merge-all --no-gzip -o LCL7.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " father_vcf_gz}
rtg vcfmerge --force-merge-all --no-gzip -o LCL7.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " rename_father_vcf_gz}

rtg vcfmerge --force-merge-all --no-gzip -o Twins.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " twins_vcf_gz}
rtg vcfmerge --force-merge-all --no-gzip -o Twins.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " rename_twins_vcf_gz}
>>>

runtime {

+ 21
- 6
workflow.wdl Bestand weergeven

@@ -2,6 +2,7 @@ import "./tasks/variantsNorm.wdl" as variantsNorm
import "./tasks/sister.wdl" as sister
import "./tasks/mendelian.wdl" as mendelian
import "./tasks/zipIndex.wdl" as zipIndex
import "./tasks/VCFrename.wdl" as VCFrename
import "./tasks/merge.wdl" as merge
workflow {{ project_name }} {
@@ -82,16 +83,30 @@ workflow {{ project_name }} {
cluster_config=cluster_config,
disk_size=disk_size
}
call VCFrename.VCFrename as VCFrename{
input:
mother_vcf_gz=zipIndex.mother_vcf_gz,
father_vcf_gz=zipIndex.father_vcf_gz,
twins_vcf_gz=zipIndex.twins_vcf_gz,
mother_vcf_idx=zipIndex.mother_vcf_idx,
father_vcf_idx=zipIndex.father_vcf_idx,
twins_vcf_idx=zipIndex.twins_vcf_idx,
mother_name=sample[7],
father_name=sample[6],
family_name=sample[8],
cluster_config=cluster_config,
disk_size=disk_size
}
}

call merge.merge as merge {
input:
mother_vcf_gz=zipIndex.mother_vcf_gz,
mother_vcf_idx=zipIndex.mother_vcf_idx,
father_vcf_gz=zipIndex.father_vcf_gz,
father_vcf_idx=zipIndex.father_vcf_idx,
twins_vcf_gz=zipIndex.twins_vcf_gz,
twins_vcf_idx=zipIndex.twins_vcf_idx,
rename_mother_vcf_gz=VCFrename.rename_mother_vcf_gz,
rename_mother_vcf_idx=VCFrename.rename_mother_vcf_idx,
rename_father_vcf_gz=VCFrename.rename_father_vcf_gz,
rename_father_vcf_idx=VCFrename.rename_father_vcf_idx,
rename_twins_vcf_gz=VCFrename.rename_twins_vcf_gz,
rename_twins_vcf_idx=VCFrename.rename_twins_vcf_idx,
mapper_caller=mapper_caller,
cluster_config=cluster_config,
disk_size=disk_size

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