@@ -1,5 +1,6 @@ | |||
{ | |||
"{{ project_name }}.fasta": "GRCh38.d1.vd1.fa", | |||
"{{ project_name }}.VCFrename.docker": "registry-vpc.cn-shanghai.aliyuncs.com/pgx-docker-registry/rtg-tools:latest", | |||
"{{ project_name }}.sister.docker": "registry-vpc.cn-shanghai.aliyuncs.com/pgx-docker-registry/vbt:v1.1", | |||
"{{ project_name }}.mendelian.docker": "registry-vpc.cn-shanghai.aliyuncs.com/pgx-docker-registry/vbt:v1.1", | |||
"{{ project_name }}.disk_size": "150", |
@@ -0,0 +1,40 @@ | |||
task VCFrename { | |||
File mother_vcf_gz | |||
File father_vcf_gz | |||
File twins_vcf_gz | |||
File mother_vcf_idx | |||
File father_vcf_idx | |||
File twins_vcf_idx | |||
String mother_name | |||
String father_name | |||
String family_name | |||
String docker | |||
String cluster_config | |||
String disk_size | |||
command <<< | |||
echo "MOTHER ${mother_name}" > mother_rename.txt | |||
rtg vcfannotate -i ${mother_vcf_gz} -o ${mother_name}.rename.vcf.gz --relabel=mother_rename.txt | |||
echo "FATHER ${father_name}" > father_rename.txt | |||
rtg vcfannotate -i ${father_vcf_gz} -o ${father_name}.rename.vcf.gz --relabel=father_rename.txt | |||
echo "CHILD ${family_name}" > child_rename.txt | |||
rtg vcfannotate -i ${twins_vcf_gz} -o ${family_name}.twins.rename.vcf.gz --relabel=child_rename.txt | |||
>>> | |||
runtime { | |||
docker:docker | |||
cluster: cluster_config | |||
systemDisk: "cloud_ssd 40" | |||
dataDisk: "cloud_ssd " + disk_size + " /cromwell_root/" | |||
} | |||
output { | |||
File rename_mother_vcf_gz = "${mother_name}.rename.vcf.gz" | |||
File rename_father_vcf_gz = "${father_name}.rename.vcf.gz" | |||
File rename_twins_vcf_gz = "${family_name}.twins.rename.vcf.gz" | |||
File rename_mother_vcf_idx = "${mother_name}.rename.vcf.gz.tbi" | |||
File rename_father_vcf_idx = "${father_name}.rename.vcf.gz.tbi" | |||
File rename_twins_vcf_idx = "${family_name}.twins.rename.vcf.gz.tbi" | |||
} | |||
} |
@@ -1,21 +1,21 @@ | |||
task merge { | |||
Array[File] mother_vcf_gz | |||
Array[File] mother_vcf_idx | |||
Array[File] father_vcf_gz | |||
Array[File] father_vcf_idx | |||
Array[File] twins_vcf_gz | |||
Array[File] twins_vcf_idx | |||
Array[File] rename_mother_vcf_gz | |||
Array[File] rename_mother_vcf_idx | |||
Array[File] rename_father_vcf_gz | |||
Array[File] rename_father_vcf_idx | |||
Array[File] rename_twins_vcf_gz | |||
Array[File] rename_twins_vcf_idx | |||
String mapper_caller | |||
String docker | |||
String cluster_config | |||
String disk_size | |||
command <<< | |||
rtg vcfmerge --force-merge-all --no-gzip -o LCL8.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " mother_vcf_gz} | |||
rtg vcfmerge --force-merge-all --no-gzip -o LCL8.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " rename_mother_vcf_gz} | |||
rtg vcfmerge --force-merge-all --no-gzip -o LCL7.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " father_vcf_gz} | |||
rtg vcfmerge --force-merge-all --no-gzip -o LCL7.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " rename_father_vcf_gz} | |||
rtg vcfmerge --force-merge-all --no-gzip -o Twins.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " twins_vcf_gz} | |||
rtg vcfmerge --force-merge-all --no-gzip -o Twins.${mapper_caller}.sister.consistent.merged.vcf ${sep=" " rename_twins_vcf_gz} | |||
>>> | |||
runtime { |
@@ -2,6 +2,7 @@ import "./tasks/variantsNorm.wdl" as variantsNorm | |||
import "./tasks/sister.wdl" as sister | |||
import "./tasks/mendelian.wdl" as mendelian | |||
import "./tasks/zipIndex.wdl" as zipIndex | |||
import "./tasks/VCFrename.wdl" as VCFrename | |||
import "./tasks/merge.wdl" as merge | |||
workflow {{ project_name }} { | |||
@@ -82,16 +83,30 @@ workflow {{ project_name }} { | |||
cluster_config=cluster_config, | |||
disk_size=disk_size | |||
} | |||
call VCFrename.VCFrename as VCFrename{ | |||
input: | |||
mother_vcf_gz=zipIndex.mother_vcf_gz, | |||
father_vcf_gz=zipIndex.father_vcf_gz, | |||
twins_vcf_gz=zipIndex.twins_vcf_gz, | |||
mother_vcf_idx=zipIndex.mother_vcf_idx, | |||
father_vcf_idx=zipIndex.father_vcf_idx, | |||
twins_vcf_idx=zipIndex.twins_vcf_idx, | |||
mother_name=sample[7], | |||
father_name=sample[6], | |||
family_name=sample[8], | |||
cluster_config=cluster_config, | |||
disk_size=disk_size | |||
} | |||
} | |||
call merge.merge as merge { | |||
input: | |||
mother_vcf_gz=zipIndex.mother_vcf_gz, | |||
mother_vcf_idx=zipIndex.mother_vcf_idx, | |||
father_vcf_gz=zipIndex.father_vcf_gz, | |||
father_vcf_idx=zipIndex.father_vcf_idx, | |||
twins_vcf_gz=zipIndex.twins_vcf_gz, | |||
twins_vcf_idx=zipIndex.twins_vcf_idx, | |||
rename_mother_vcf_gz=VCFrename.rename_mother_vcf_gz, | |||
rename_mother_vcf_idx=VCFrename.rename_mother_vcf_idx, | |||
rename_father_vcf_gz=VCFrename.rename_father_vcf_gz, | |||
rename_father_vcf_idx=VCFrename.rename_father_vcf_idx, | |||
rename_twins_vcf_gz=VCFrename.rename_twins_vcf_gz, | |||
rename_twins_vcf_idx=VCFrename.rename_twins_vcf_idx, | |||
mapper_caller=mapper_caller, | |||
cluster_config=cluster_config, | |||
disk_size=disk_size |