@000
AGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTT
+
@@@DDDFDHHDFDGEGHIGEEFHGIJJIJJJIGGIJICEGEDGIEHIHGF>DEFFFFEDECD?B?BCDDCD@;@DDDCC(4?4>@CCDDDDCCEDDDA:CC
@001
CACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTT
+
@@@FDDFFHD>FFB@E@GHEHEHICBC;@6B6DDHEGAGC?FCC=CF@<(;@=>CAFE;;7@D@DCC@CDC@55(5@A<>CC?CC?>>82::44@C?CCCC
@002
CTCGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGA
+
B@@FDDFDHHGHHJIIJIJJJJIGGJJJJIIJJJJJJIJIJIIJJJIGJJJJGIDHHHIJJIJJJJGIJJEIJGIJJJHHGHEFFFFFDEEDEEDDCDDD
@003
CATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTG
+
?@@D;B;D?FFDF@CEFGF:6?ECFBBFFIFBFD?866DEEFC3C855@DEFEE@E>=AE>B7@BCAC=>>BA@;?>ABB3:>BBBBBBBBA@>>A@<<@
@004
ATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAA
+
@@CFFFFDBFFDHICFDGCBHIICGEA?FHHGHGH>FGIIFHGGEGGIIIEB-8CEH=F=FEGEHBH>B:;@C9@A:BCDDDDCDBDB@DDDCD9??AAC
@005
GCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTC
+
CCCFFFFFHHHHHJJJJGHIJJJJJJJJIJJJJFHJJJJJJJJIJJJJJJJIJJHDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDCD:AB>CCDDD
@006
TGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTG
+
CCCFFFFFHHHHHJJJIJGHJJJJJJJJIIJIJJJJJJJFHHIGHGIJIJJJJJGJJJJJHHHHFFFFFFEEEEEEDDDDDDDDDDDDDCDCEDDDDDD39
@007
CTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJEHIJIJJJJJJJJJJJJJJJJJJJJJIIJHHHHFFFDEEDEDDDDDDDCDDDDDDDDDDDDDDDDDDDB
@008
TGATGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCCFFFFFHHGHHIIHIJIIJFHHJGIJJJJJJJIJJJJJJJIIJJJJJJIGGIJJIJIGIJIIJJJIFHHHFDDBBDDDDD@CCDDDEDDCCDDDCCDD
@009
GGGGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
CCCFFFFFHHHHHJIJJHGIJJJIJJJJJGHIFHI@FHJIJJIJIJIJJIHGJJJJIHHHHFFFFEEDDDDDDDDDDDEEDDDDDDDDDDBDCCDDDDC
@00A
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
C@CFF@FFAFFHFIJIIIJIJJJJJCHIDICHGHIEHHIA3BE@ACFHIJIJJHGHBBCCCEEEDCDDCCDDB@DDDCDDCCCDDDDD>CCCDDDCDCCCA
@00B
GTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGTGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATT
+
@?@DDDDDBDFFAFEAG?EA?BF+?=EB1?DF>BEFCF@DDCCCGICD?FCC@@FFFEGII@EEFCAECAE??DD;?B;@A;>CCBBBBBBB?BB5:ABD
@00C
CTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTG
+
?@<DDDABDHBHCGHBHIIIIIIEDHIGIIC9:?@F??<BFDGDEGCIIIEGEHHE>@F@A866AAHDDBBBAECAC>CCCC:>A>@@ACCDCCCAC@@:
@00D
GTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTC
+
@C@FFFFFHHHHHIIJJJJJIJJJJIJJJJJJIJJJJJIIIJIJJJIJHGGIJJJIIJJHIIJJJIJJJJJJJIIJIJFHIJGIJIHHHHGHFFFFFFFE
@00E
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJGHIIJJJJJIJJJJJJJJJJJJJIJJJJJJJHHHHHFFFEEEEEEDDDD8?D@DDDDCDDDBDDDDDDDDDDD
@00F
ATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTA
+
@CCFFFFFFCFHFGHIGIGIGIIEEHAHIIHDEHIIJEHHIICDHIGIIEGHIIIJIHIIEGIIIIID>GFGGBF@FHG@DGHGHFHGFFDEEFBC@C>C
@00G
GTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCC
+
?8?BDDDDHBDHHGAHGBFGIE<DFECG@HDG@EEAF3CCFHG@BF?F9:9?FGGFGBHGGIDFCEGACHCDFDEEGIGDHHHE=AA3@B@;@@B@@;>@B
@00H
TGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGGCTACAGTCTGCTATTCTCCC
+
?@@DBDD?CFFC<??AFDFD?A@+A@BGGCBDFIAGEDABA:60CB@<CFEFACE@E;==;3).=(;;@DC>>ABB=>=(,955A>5(:AB>AAB>B>@>
@00I
GGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCT
+
@@@FFDB?DFHFHIIIJIIHIJEGHHJJJGHIIBHEIGGHIJJGIHHFFF@DDCE@CDCCCDDDBDDDDDDDDD>@D8AAC4>?44@@CDCCDCCDCCDCC
@00J
GCTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGGGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCG
+
?;=DBABDFFD<F<EF@2<F@:A4CECBC2+*?CE149CDDECEFCEEA?DFI'5&075?8?B@BBB@;?>@@3<B@99@BBA>B@B4::4<<B9<>4>A8
@00K
CCTTCATCCATGGGTCCACCAGGCTTATTGAAGCCACCTCGCTCTCCAGCGCTGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCC
+
CCCFFFFFHHGHGJGIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIIJIJJJJJJJHHHHHHHFFDDDDBDDDDDDDDDDDDDDDDDCCCDDDCDDDDD
@00L
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHHHHIJJIJJJGHJJJJJJJIJJJJJJJJJIJJJIIIIJJJJJJHHEHHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDD
@00M
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJIIIJJJHIJJJJJJIJJJJJHHHFFDDEEDEDDDDCDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDD
@00N
CTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAA
+
CCCFFFFFHHHGHIIIIIJJJJJJJJJJJJIHJIJJIIJJJJJJJJJJJJJJJIIIJJJIIIJGHHHH=@DCEEDDDDCDDDDDCDDDDDDDDEDDDDDD
@00O
GCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTC
+
CCCFFFFFHHHGHJJJJJJIJHIHHIGIJIJJHHIIJIJJIIJJIJIJIIJJJJJFHIJJHIGHHGHFFEFEEEEEEDDDCDDDDCD?BDDDDDDDDDEED
@00P
GTTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTG
+
@C@FFDDDH@H@DFGHIIIGJEHIGC?E@BHIHGHAFDBDB?DFDGHCB?<DDFGC=FCCAFGIIJEG>B6=?B?CAECDDB6=5:@ACCACD:>>?>A?
@00Q
CTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATC
+
CCCFFFFFHHHHHJJGHIJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIIJJJJJJJJJJJJJHHHHHHHFFFF
@00R
TGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJGHHHGFFFFFFFEEEEEEEDDDDDD;ACDDDDDDDDDD
@00S
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CCCFFFFFGHHGHJJIJJGHGHHJJJJJJJJIIIJJJDHGHIIJIJIGHIJJIJIHHIIIIIJIGEDD>CCEEDDCDDBDDDDDDDDDCDDDDDCDDDDDD
@00T
CCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATA
+
@@@DDDBDFHBHFHIGGGHH>CHGHIH@ECH<21:CFBD?GGHIIC@BF@B<@FF@<F@8@=3)7=DA;=AE@?BEC<=;5;A@AA?>:::@ACBBBA:
@00U
TCAAAAAGGGATTCAATTGCCATCCATTTAACTGGAATCCGACCCTGGCTCCTCTTCACGTAGGAATCCTCTTCATAAACATCTCGGGACAAACCGAAATC
+
<;?DDDDDFFDH?HGIDG>FHHHGGEEHIIIIGCGGGIIIGHIIGCEGHGIGIII7@@DA6.?EHFECDCE>CCD@ACCACCC>CABBB@BBCBBB99<BC
@00V
AGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTC
+
@B@FFFFFHHHHHJJJJJJIIJJJJJJJJJJJJJJJJJJJIIJHIJJGIJJJIJJJJJIJGJJHJJJJJIFGHIIJJJJGIIJJHHHHHHHFFFFFFEEEE
@00W
ACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGACATCTGTTTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATG
+
=?:A;4BD=FAA6;E9E>CHC?HC9EB>9EE9?C9?9?CFH@<4?FGI**9?*?<8@:'-5C==?E)7=;B@BDE>;AA(;@(-,;?::(5,>>:(<<AC>
@00X
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
@CCFFDDFHHHHHJJJFFHIGIJIJJJJHI?GHIJJJJJJJIJJJIJIIIIIHGHIJIG@FDGIIIIGHFHHDDFF;>CCECDD5>@BCCDDCDD8?CCDC
@00Y
CACCTTCAGGGGGTCAGCATTCTGGAGCAGGTGCATCACATGGTCCTCTGTCATGTTGCCATACTTGGTGGCATTCTGCATGGGCCCCTGGGGCAGGGCTC
+
CCCFFFFFHHHHHHIJJJJJJJJJJHIJJIJDHIIJJJJIJJJJJJIJJIIJJJJJJJJJJGHHHHFF?DFEEEEEEEDDDDDDDDDDDDDDDDDDDDDDD
@00Z
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAAC
+
;?@=BD@DCF?A;EFEE2AE9DBCEE*:?DDG@9?B<9BG>DH?8*?BG<<BF==FH2CHI@(?66<5;?(>C3;6;5=7?B<5-&++::@3@C>>>>BBA
@010
CCGGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGC
+
@@@DFFDDDDDBFHHEGHHIJDIJJJFEEHGEGIDG0?DHHGHDCFC8AHCAHEHGFCEDDCDCDAD>;?CCDCDACCCCCDDDCD>AADC4>ACD>:@<A
@011
CTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGG
+
CCCFFFFDHDHHHJJJIGGGGIJJJJIIJGJJGIIIGIGJIIIDCHGIJIEGGGIEHIJIJGGIGGEGEEEEFEEDEFFBDCEEFCCCCCDDCDDD<BBB
@012
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
CCCFFFFFHHHHHIHIJJJIIJIIJJJJJIJJIJJJIJJJJIJIJIIJJJJJJJJJIJHHGHGFFFFFDEECEDDDDDCCDDDCDDDDD9@CDDDDDCDDD
@013
CTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJIIJJJIIJJHHIJJJJJJJJJJJJIHHGHHFFFFFFEEEEDEDDDDCCDDD
@014
TATGATCAAAAAGGGATTCAATTGCCATCCATTTAACTGGAATCCGACCCTGGCTCCTCTTCACGTAGGAATCCTCTTCATAAACATCTCGGGACAAG
+
@@CDFDFA<CFFD@DHDHEFHBAFGHIIIIGGGIIIGFHEGIAHD?D@FI88.=@FGIGHAECDAEEHFEF;C@>@A@C>C@CCC@C>CC???BBBBB
@015
CCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCA
+
CCCFFDEFHFHHHIJIJJJJJGJJJJJGIJJJIIJJJIJJJIHJJJJJJHIJJIFIJJJJJIJJJIJJIHGJIIGGIJJGHFEHFFFDCCEDBBDDDDD
@016
AGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGAACTACTACTGATGCAATGAAATAAACTATTTCCCC
+
CCCFFFFFHHHHHJJJJJJIJJIJJJJJJJCGIHHIJJIJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJJHHHHHHHFFFFFFEEEEEEDDDDEEDDDD
@017
GTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGC
+
@@@DDDDDCBF?FD@:@FH>HEH@DEA@D?DFC@C<DDHIDHIE4?FGIHGHGDHA@@A=>;??AH@B@@>DCC@>BBBBBCCC>>>:@CCCC8?<809
@018
GTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTG
+
@@@FDDDDHFFFDHGIGJIJJJIJGGIJIIIGIHJIJJJGIJHHEHJJBFGDGIIHGIHIJGGEEFDFCEB@C=???BBB@BDBB?@CCCCDEDDDBDDBD
@019
ATAGAGTTTGTTTTCAATCCATGTGGAAAGGAGGGCTCGAGGGAGGGTGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCAT
+
?@<D=?D:DFF?DG<?GFE;AFH3<A?ACF?F?E)?)BD0@?-'--'-('()7).7?DAC(;;;;;?9?=/,,3&+:>>++>(3>A:4:A02<&))5)212
@01A
CATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGA
+
C@BFFFFFGHHHGJIIIJJJIHIJIJJJJIIFIIJGIIIJIGGGHIIHIIJJJIIJBFCCGIIGIGHHHHFDEEDDEFDEEDDDDDCDDDDDDDDDDDD
@01B
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
CCCFFDFFHHHHHJJIEGIIIJJJJJJJJJGHIJIJJJIJJHJJJJJIJJJIGGIJJIIFHHIIEIJEHHHHFFFF@ACD>CDD5>?DDDDDDDDBDDDDC
@01C
CCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCGATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTC
+
@@@FFD>BDHHFHGIGGGEGHEGHCGGIIEEH?@DHGGHHIIDIIIHDCA>BD@?CD@CCCDBDDDAC4?@BD@BB5>DDDBCCDCD<BC>CCC:>AB>DD
@01D
GGGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTT
+
@CCFFDDDFADFBGG4CFGHGHA@EHIIIHEEEHIIIEDFDBEEEEFFEAACA>@CC@CCA787;7@CCCA@>B@BB<CC+:8:::>AC@ACC@DCCCACC
@01E
AAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTG
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJ;BHHBEFFFFF@EEDCDDDDDDDDDDDDDDDDDDDDDDDCDD
@01F
GAGCATTTGGGAGAGCCCCAGCTCACCCTTGGCCTGGCGTGGCTGTCCATCCACAAGGATCATTGCATCTGGCCCATGGGCCCTGAGGAACTTATTCAGGT
+
C@CFFFFFHHHHHJJIIIJJIJJJJJJIJJJJIJJJJJJIJJJJIJJIJJJJJJJHHHHHFFFFFFEEEEEEDDDDDDDDDDDBDDDDDDDDDDDEEDDCC
@01G
GCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCAT
+
CCCFFFFFHFHHHJIEHGIHIIJFIJJJJIHIIIGEIIIJIJJI@GD>GH??DGEFFHDGGAHIIGJGHIHIIJJIIIIJHFHHDEFDFFEEECEEDDBCD
@01H
TGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTG
+
BCBFFFDFHHHHHGJJJIJJJJJGGIJJJJJJJJIJIJJJGGJIJJIJGIIEHCGIIIJJJJJJIIHGHHGFFFFFFEECCEDBDDDDD<@B@BD5?CDDD
@01I
GTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAA
+
CCCFFFFFHHHHHCGAFGGIIJJIGIIIFGGIIIJJJJJIJJIIJEHIGHCGGIIIJIIGIGFIIIGIIJGGGIJHHHHCCEFFFFFDCCDBBDDCDDDD
@01J
TCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTT
+
CCCFFFFFHHHHHJJJJJJJIIJJJJIIJJJJJIJJIJIJIJJJJIJIIJIGIIJJIIJJJJJJCGHGIAHGHGHHHFEFCEFEEDEDDDEFDDDDDCDDD
@01K
CTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCT
+
CCCFFFFFHHHHHJIIJIIJIJJIIJIJJJJJJIIIJIIIGHIJIHHFFFEBACDDEDBDD?BCDDDDCDCCCDC@BD2<:>:B>>CDDCCCDDCBDCCCD
@01L
GCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGG
+
CCCFFDFFHHHHHJIJJJJJJJJJJJJJGIIJJJFHIJJJJJJJJJJJJJJIJDGHHIGGGIJHGHIHHHHHFHCEFDCEADDEDCDDDDDDDDDBDBDDD
@01M
CCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGT
+
??<B;3:4?:ADD=;AAC+<AA<:AF3<32+<A<FEDGC@)::C<FFB?:)000?*B<F:((77@C=C;C7(6?>A3=3?)7;))7?>ACABCCB@5>A:'
@01N
CTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGC
+
BCCFFFFFGHHHHIJJJJJJIJJJJIIGHIIJIJGHHIJIHHIIIIGIIJIJIGGIJJGHGIIGJIGIHJDHHHGHHFFCEFEECCCBDDDDDDDD09@A
@01O
CTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTT
+
?@@D:DD;AFAACB2A<<A?<AEGI;FH<AC:8C??*:?D@F:8B?(7-8=FCA;=@A7=;B>??@>775@>CCC>CC@>C;@CACCCCC:>ACD>C@CCC
@01P
GGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTCTC
+
@<@DDADDH1@D?FAFH@FHG?FD<D@G?DDEDGGGHICGIII3??EEC3@9)7.>>>>>;>C@1;=<@;BBB8A>@>CC@>A>:A3:4???3??8@@>@
@01Q
GGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGC
+
@BBFDDDFHHHHHJJJJJFHHJJJJJJJJHIIIGIJJGIJDGHJJJJJJJJIIJJHHFDDDED@CDDDD@B@CDECDCDDCCDDDDBCCCCDCDEDDDDD
@01R
GAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGG
+
C@CFFFFFAFHHGJJJJJJJJJJJJJJJJJJGIJJIJHHFGIJGIIIIEIHHIHHHHHFFFFFEEEEEEECCDDDBDDDDDDDD<B>BDDBDDD@C<BDDD
@01S
GCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTC
+
B@BFFFFFHHHHHJJJJJJJJJJJJJJJJIIHIIJHIIJJHIIGGIIJJJIIIJJJJIHIJJIIIJJIIJIJGIJ@FHJHEHIIHHHHEHFFEFFFFFEEA
@01T
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
@@@B?;DAB<DC@FFHD<2C@EGH@GHIGHC<DFHIHH9F48B?F3CH>BHD@CEGH=<DD@@>6>A>>BBCCA@CC@CCCAC?B@BBBBC@?@>>ACCCC
@01U
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGGCTTGTAGGTGCAGGGG
+
;?@DDDDDF?FF??E+<:+ACEF>FFAF<F@@@FAG?D99B*9?DFFI3BDFF<<)8=@C@CE;).;ACDDD@;>.>A;>A:8;'0<<<<AA:>:A>B(&5
@01V
CTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGG
+
BCCDFFFFHHHHHJJIIIJJJJJJJJJJJJJJJJIIJIJJJJJJIJJJJJIIJJJIJJIJJIJJIJHIJGCHIJJJJIIJHHHHGFFFFDEDEEDDDDDDD
@01W
CGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGGGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGC
+
@@CFDDDDBFDHDCEFDG@ACFFGGBEB@GBAGBBDHBH@G'58@G@AHHEEDFCCCBB?@BCC55>A@B@2)4:A(:::@CC@CACBCCACCCCDCACCC
@01X
GGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGG
+
@@@FDDFFFHFFHGGIIIJJIJIJJGGCHEGIJJJJFFHHJJIJJIIIIDHIIIIJ9BFGH@F>DCGHCHIIJHFFFFFDEDDC?C@CF>C?@D
@01Y
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAAC
+
CCCFFDDFHHHHHJJJJIJJJJJHHJEGIFHIJJJIJJIJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFEEEEDEDDDDDDDBDDDDDDDD@CDDEDEED
@01Z
CAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATAT
+
1=?D=D4AAC<CB3E?C2++A<FEF9@B+1:<C?EFF9DD@DDD30?DDCDD>??D?BCCC:B4@8=C@A@.=ACA:=':<?';;@(;3;;5;:5>??AAB
@020
GGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGAC
+
CCCFFFFFGBHHGJIJJJIIIIIIIIJJIIGIIJIIFHIGDBCBBCDDDDDDDDD?BBDDDDDBDBBDDDDDDDDDDDD<CCDCCDDEEDDDDCCDDDDB
@021
AGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAG
+
<?@DDDDDADHFHGADGICFH?FFGA@HIII?HGGGIIIIGHGIIHEHHIICFHII=DHHFFFFE>@>CCCC@BBCBCDDCAC
@022
GCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCG
+
@@@FFFFFHGHHHJJIJIFGHJJGJIIGJIFHIJJJIJJGIFHGEHIJJJJJIGIJIJJJJJIIIGGHHHHHHFDFFCEEEEDDDDDDDCDDDDDDDBBDD
@023
CACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCACAGATCACTGGGATGCCCTACGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGT
+
CCCFFFFFHHHGHJJJJJJJJJJJJJIJJJJIJEIJJJJJIIJJJIIJJIIIIIJJJJJJGIJJJHHHHHFFFFFFFEEEEEEEDDDDDDDDDDDDDDDD5
@024
ATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCT
+
C@@FFFFDHHDHHIIIGIE>CFDHGCHGGEHHHHFFHIHIIHHHIIIIIHIHIIG>DHIIICGECHIICFBEEEHDGCHGIAECEHEHHFFBBDDD>CCC@
@025
TGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTGGG
+
CCCFFFFFAHHHHIIIIHHHIIIIIIJJIJIIJJJJIJJJJJJJJIJJGIJJEHJ8BFHIIIIGHJGEFHHHFFFEFFEEEECDDDDDDDDDCDDDDDDCD
@026
TGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGAT
+
CCCFFFFFHHHHHJHIJJJJJJJJJJJJHJJHIJJJJJJJJJJJJJJJJJJJJIIGIIJIJJJJHIIFIJGIIIJIIIJJJI@EHHGHHHHFFFFFFFECE
@027
CCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTC
+
@CCFFFFFGFHGHJJGHGEHHIGEGHIGEIGDGBHHHGGBFHGIIJGGHIDGGIIJIICGICDADGGGF@AEH?CH;??ACCCCECCC;>CCCDDCCCCD
@028
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@CBFFFFFHHHHHJJJJFGHFHIJJJJJJJJJJJJIJIJJIJJJJJJJJIJJJIIJJJIJJHIJJIIIHHHFDDDDDDDDDCDCCDCDDDEDDDDDDDD
@029
GTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTG
+
@?@FFEDDH+CFHFHIJGIHCGGHJIJJIIIJGIJIIJIIJI7DHIJIIJIJIDHGGIJHHHDFFFFEEEEEEEECDCDCDDDDDDDDEEDDDDDDDDDDD
@02A
GGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTCTC
+
CCCFFFFFGHHHHIJJIGIGHIHIIJJIGIJJJGIJHIEIIIIHHHHFFFCEF;AACEFDEEEDDDBD?CBDDDDDEE@C>CCDDDDDDDDCDDDDDDDDC
@02B
AGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTT
+
CCCFFFFFHHHHHJJJJJJGHJJJJJJJJGIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGHHHFFFFFEEEEEEEDDDDDDDDDDDDDDDDDDEEE
@02C
GCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGG
+
CCCFFFFFGHFFHIJJJIJJHHGG@HIGGGIIJIIIIJJJJIJIJBFGIIJJJJJJIIIJJJJJJIHHHHHHFFFBEFEDDEEECABDDDFDEDDDDDCDC
@02D
ATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTGCTTATCTTTAGCCTCCAATTATCTCCTACTTC
+
@@@DDFEFHHGHHJJJIIIEHJGJIIEHG>HHGGIGEIJIFHIGIIGHIJIIHIGHGIIJGEBFHI@HGCHIGHIJJGGJIJIIGEHAECAEDCDFFEC
@02E
CTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGG
+
@@CDFFFFHHHHHJIJJJJJJGJJJJJJJJJJJJIJJJJJJJHJJJIJJJJJJ;BH?DFFFFEDDDDDDDDDDDDDDDDCBDDBBDDDDDDDDDDDDDDDD
@02F
GGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAA
+
CCCFDDFFGFHHFBGHIIJJGIIBHIBEGGDHDGGIHGGIJJIJ>DH@@;DGHGHCEEHHFFEEACDBDDDBDD?ADBDDA<?A?>CCCDC@CBBCDCC
@02G
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGT
+
CCCFFFFFGHHGHIJIIJIHIJHGHIIJJJJJJJIJJJIJBGIJJJGIJJJJJJJIJIIJHGEHHHHFFFFFEEACDBDDDACCDCCDDDCCDDD9A>A@C
@02H
ATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCT
+
@@?DDDDDADFD?BEFGB>DEFH==FGCHGGGGEEGIIGHGIIEBABFGIGIIGI@<8BFFHHIIGIIEGIGCEEFEFD?CCCCCACC@CCCCCCCAAAC>
@02I
TTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAAC
+
?88A=++?DD4CAEEEED:CAA:AE>+<EED+A?CEEEC@*8:D1089DDAE@4BDDEE=)B:87.=A@>AC4=@CCDC3?CD97;?A(.>3;>A53(-;3
@02J
CCCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTG
+
;?@D;==@BDDFFEBE:<<ACEHIEA@CBBGFIFAF>CDFD9D<BFDDBFD?FDA@6FBCE=CEEEFFFFDDDDDD@ABC;;ABA@BBBBBBABBBBBBB@
@02K
CGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGT
+
@C@FFFFDHFHHDHHHIIJIIJJJJJGJJGIIJJJJJJJIGHJIJDGHIJHIJHIIIHIGHHEGIJHIGIIIGIIG@FGIGJJFHGHGFFFFFFDEEDB
@02L
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
CCCFFFFFHHHHHJIJJJJJJJJHIJJJJJJJIGIHIIJJJJJJJJJJGHJJJJJIJIJJJJJJJJJJJJIJHHFFDEECFDEDDDDDDDDDDDCDDDDDD
@02M
CCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTTGACTTCG
+
@@@FDDDFDDFHHIGIIJJIIIEIIIIIGGIJIJJJJEEGGGIIIGIADGBGHGJJJJGFHHHGHD@DDFECEC@AACCDC;@C@55:A@CC>A>>CACD@
@02N
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@@@FDFFFGHFHGHIJIGJIIGJIIIJHHFGIIIIIJEGGIJGICGIGGIICHCFGCHGGEEHFHGGFEBEDCD6;;@@CDACCDDABCCCDDDDDCCCCC
@02O
AGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATC
+
CCCFFFFFGHHFHIIICGIIIJEHIIIIIIGIJJJEGHHIDGHJJJIJJEFEFFFFFDECADEDDDDDBDCABDDBDCDACDCDCCCCDEDACDDDCDDCD
@02P
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFFFGHHHGJJJJIIJJJIJJJJJJDCDDDDDDDDCDDCDDEEDDDDCDDDBDDDDBBDDDEDDDDDDCCDDDEDDDDBD9BDDDDDDCDDDCDDD
@02Q
CGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGC
+
BBCFFDFFHHHHHJJJJJJJIJJJJJJJJJJJJJJJIJHJJJJJHIIJJJJJJJHFDDDDDDDDDDDDDDDDDD<BDDDDDDDDDDEDEDDDDDDDDDDDD
@02R
ATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTT
+
@CCDDDDFFDHGHHIJJJGGHHIGEHIIIGIEIGIIGIHIJJJJI;ABFFFCDDECEEEDCDECDCDDDDEDCDCDDD8<@<CCDCDDACDDEDDDCDDDD
@02S
CTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTT
+
CCCFFFFFHHHHHIIIJJJJJJJIJJJJIJJJGJJGIJJJIJJJJJJIJIJFIJJIFGJIJGIIIJJIIJJJJJJJIFGEHHHFDDFFFFEEEEEEEEEDD
@02T
TAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTC
+
BCCFDFFFHHHHHJIIJJJJJJJJJIJJJIJJJJJJJ?@??HHIJJJJJJJJJJJJJJHHHHHFFFFFFEEEEEDDEEEEDDEEDDEFDDDDDDDDDDDDD
@02U
GGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGG
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJDHHIJJJJIJJJJJJJJJJJGEHBFFDEEEEDDDCDDDDDDDDDDDDDD9?BDBCDDDDDDDDDEDB
@02V
GTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGC
+
BBCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJIIEIJJJJJJJJJJJJJJJCGIHHHHHHFFFFFDDEEEDEFDDDDDDDDDDEDBDDD
@02W
GCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGACACCAAAAGACCAT
+
?@@BDFFDHDHGDHHBC<AFHHIFIJBHGGIGGIBBGIIIIIIIC=BFHHHIGEEEFEDEEDEED@CAC??<ADDDCDDBABCBBDDDDDBBDDDBCDCC
@02X
GACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACT
+
CCCFFFFFHHHHHJJJJJJIJJJJIJJJJJJJJJIIJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJHHHHHFFFFFFEEDDDDDDDDDDDDDDDDDDDDDD
@02Y
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
@@@DDDDDFHFHBHIIIIIIIIC8EGIHIGG@DCHI:FCHHIIGIIIBGEGHFICHIIGGHHHFECEEEECCCBBBBBCCCC@CCCDCECCBCCCCCCCC
@02Z
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
CCCFFDDFHHHHHIJJIGIFIIJJJIIJIIGIIJJJJJJJJHHJJJJJDGFGIIJJGHIIJGIIJDHIJIHHF;@BDCCEBDDD5<CDD@CCDDCBDCDD
@030
CTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJJJJJJJJJHJIIGIJJJJJJJJJJJIJJJJIGHIJHHHHHHHFFDFFFFD
@031
GATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCC
+
CBCFFFFFFHHHHJJJJJJJJJJJJJJJJJFFHJJJJJJJJGGJJJJJJJIIJJJJJIJJJJJJHHHHHHHFFFFFFFEEDEEDDDBDDDDDDDDEDDDDD
@032
TGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATG
+
BC@FFFFFHHHHHIIIJJJJJJJJJJIJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJHHHHDFFFFEEDDDDDDEEDDCDDDBDDDDDEEDDDBDDDDD
@033
ACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJHIIJJJJJJJJJJJJJJJJJJJJJJIJJJJFHJIJJJJJJIJJJJJJJJHHHHHHFFFFFECEEEEEDDDEDEDD
@034
TGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHGHGHJIJIHIJJJJJJJJJIJJJIJIJIIHIJHIJJJIDHIJJH?>CCEDDDDDDDDDDDDDDDDDDDDEEDDDDDDCDDDDDEDDDDDDD
@035
GTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCT
+
?@@FFFFFAHHHFGHGGIEGDHHH@HGGGGIIGIJJJ?@B@HHHGGHIG=BDGEI;CC7;@'=AECFHH>;CEBE;AACCC5@CCDDBD9ABCDDDB?9BD
@036
CTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTG
+
CCCFFFFFGFHHFGHGIJJIIGIIHGJIIGIAHHIIGGIJIGIJIJJIIHEEGIJEGIIIJ@F@GIEE;EHGHCHEFFFFFDDDDDCDDDCBBDDCCDD>@
@037
GGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATC
+
@CCFFFDDHHHGGIII<CDEFHHEHGGGGGIGIGIHIFGIGIGIIIGIIABBDDEFECCECDCCCCC?@CCC=@?<>C?CCCCBCC>CDDC:@CCCDDEDE
@038
CAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIIIJJJIJJJJJJJJJJJJJJJJJJJJJIJHHHHHFFFFEEEEEDDDDDBBDDDDDDDDDCCDDDDDDDEEDD
@039
CCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGG
+
CC@FFFDDFHHHHJJIGHBHIJJIIJJJJJJJIJCHIIHHEEHIIHGGEEHECCDDABBDCCDCDE>C?CCCCDCDDDD?@B8??9@CB>A?BDD:AB5<<
@03A
CCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGC
+
CCCFFFFFHHHHHJJJJJJIJJJIJIIJJJGJJJJIJJJJIJJJJIJJJIIJJIJIGIJJHHHHHHHFFFFFFEDDDADDDDDDDDDDDDDDDDDEDDDDD
@03B
TAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
CCCFFFFFHHGGGIAHHJIIJJIJJHIJIJJIJJIIGFEHHHIJJJJIJJJIHIIJIJJJJJHHHHDFFFDCEEDDDDBCDECCDCDDDDDDDDCDDDDD>
@03C
GCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJIJIJJJJJJJJJIJJHIJFIIJJJJJJJJHHHHHHFFDDBDDDDDDDDDDDDDDDDDD
@03D
AAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCT
+
C@@DFDDFHHHHGIDH=;CHDGIHFHIIIIIIIHIIIIIEHGIGIGIIHGIIIIICHIIIIIIIIHGFFCDBCEAECCCCDDBDCCCDCDCCDDDDDDDDB
@03E
CTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGT
+
BCCFDFFFHDFFFIJIIJIIIJHEIEGHIHIJHIJGIIJJIGGCHIJIJJGHIIIJJIIJEGIIIFJIICHHIIGGHFHFFFFDEEEEEDC@CCDCCCCC
@03F
GCCATACTTGGTGGCATTCTGCATGGGCCCCTGGGGCAGGGCTCCCATGGGCAGCGCCTGCATCAGCAGCGGGGTGGCCATGCGCATCTTGCTCACAGGCT
+
@@@DD;DD>=<2<CEAEFEHH@H9?BEFFFIEFDGIIE@60BFFEFCF>>CE>5CA<BD?C@>ABBABBB/82;)098?9>>>>@55>BBB::@(:@B@BB
@03G
ATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGG
+
@@CD?DDDHDH?FGBAHICGEHGHIGGG@HE<FGGGIIIIGIIGIIIIIIIGHEHD<D@:B@GDG=FCBAGEAFE@DADGHIIBH;BDD>>>@ACAC=>5;
@03H
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJFGIIIJJJJJJJJJEHHHHHHFFFFFFEEEDEEDDDDDDDDDDBDD
@03I
TCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTG
+
@@?DDDDD?FADDBEAFHHADB<FE<?;FFEGIG?3DFDGGGCHFH99D@FGGIAC4B8=<@FD@F>C=EE>.=A).;@73>>;>?@@9=BB0:>:@CCCC
@03J
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
BCBDFFFFHHHHHJIJJGHIGHIJJJJJJJJJJJJHJJJJJJJJJJJJJJJJJIJJJJJJJHJJIJJJHHHFDDDDDDDDDDDACDCDEDEDDDDCDDD
@03K
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTG
+
CCCFFFFFHHHHHJJJHJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJIJIJJJJJJJJJJHHHHF9ABDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@03L
CTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGG
+
@CCDFFFFHHGHHJJGGGHJIJGIJIJBHIIGGGHIGGJJJIIIIIJAGIIHIJJIGHFFFFFFECDDDDBDDDDDBDDDDDEDDDD@DBDDDDDDDDDD
@03M
ATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACT
+
CCCFFFFFHHHHFGHIJJIIEHIIIIGGGCCII:DFGHAHHEGIGEIGBGGIIFIIIEGHHIEHHGGG@FG>@GAEEFDB@BDDCCCDCCCABD@BBB@<>
@03N
CTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIIIJJJJJJJJJJIJJJJJJJIJJJJJJJJJJJJJJJJIJIJJJIIHHHHFHHFFFFFFDEEEEEECDDCDEDD
@03O
GTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGT
+
CBCFFFFFHHGHGJJJJJJJJJJJJJJJJJJJJJJJIJJJJIJGGIJIGIIJIIGGIIJIIJIIJIGHHHEFFFFDDDD;@D@DD8?CDDDDEDDDDACD>
@03P
CTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCTTTATCTTTTTCATTTTCCATATATTCACGAACCTGATCCACATGAGTTGAATAAACC
+
B@CDFFFFHGHHHJJJJIJJIJJJJJJJJJJJJJJJJIIJJJJJJJJJJJIJJJIJJJJJJJIJJJIGIJJIIIHHHHHFFEFFEEEEEEEDDEDDDD
@03Q
GACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
CCCFFFFFHHHGHJJJJJJJJJJJIJJJJJJHFHIJFHFHHIJJJGHIJIJJJHHHHHFFFFFFEEECEEEDDDDDCDDDDDDDDDDDDDDDDDDDDDEDD
@03R
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCT
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJIJJJJJJJII@EFDEEEEEDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDD
@03S
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGAACCAGTTTGGGGTGGGTAACT
+
?@7ABDD3ADC+AEEFBEFE?C@CEFFFECE@G::?@DBDFFD*/B).==87@;F@DD@EFA7737A?>7);76=6(;-5((,;5:@DA7=@<B@5&:>BD
@03T
CTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTG
+
CCCFFFFFHHHHHJJJJJHIJIJIIJIJIHIJJJJJJJJJIIIJIJJJFDHIJIJJIHIIJJGGGJJIIJIIJHHHHHHHFFFFFFFEEEDEEDDDCDEDB
@03U
GCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGGGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTA
+
@C@FFFFF?FDDAFGGGGIIG?FEHGHGGGG9ACEB>BEG*?FEHGCHIGGIIHI:FG@AHCHIHCGIG<E>=AAC;@>@@;(>>;A66-;>AC;>CB::
@03V
GTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTACACACAGGTCTACAAGGTCAACCAAGGTGAGTAAAGGACCATAAAACGTTG
+
@@@DDDDDHH?HDG<CGI<<CFBA:3AHHGGGGFGF;?DB4?BBHHGB@GH<FF<G;=F=)===FHG.=@AHIHEHE.;;6.66;>C;=BBCCCCCC?<<5
@03W
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
C@@FFFFEFFHHHIGHIIIJJJJHHIEGGIGGIJJIJJJJJGGGIIJJJIIIIGIG;BBHEHGFFDFFCCCCECCCDCCCDCCC?CADB?CDADDDCDDCC
@03X
CCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGTACATCTCCTCGCTG
+
@?<DDDAADBCADGGA@F3:AH@@C@BD+2AF111)08:?:6)?AAD4.).==@;EAA?DE:?>6(>;A?>@(>CC@<5@@:C<8&)5&+4>:>AC3&&8<
@03Y
CTCTGTTTTTCATTAACCTTATTTCTCTTATCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJHIIJIJJJJJJIJJJJJJJJJJIJJCEHHHFFFFFFEDEDDDDEDEEDDDDDDDDDDEDB
@03Z
TGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCT
+
;?<DDDDFFHHHFFHEGIIJGGGEFHIGHBH?DFG9?DFHG@DEGGBGDHIHDEFHCFD@C@FHGIGH:?CD?CCCDCC;@BBBBD@<A2ACC??:AA@>C
@040
CCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCTGTGCATCCCTCTGGGGCTATCTAGGGCTTGCTCCTGCCCACCATGCACTTCTCTTGCCCGTTTT
+
@8=DBDDD?B?F?DGEFGDBB=CFGGF<DG@BDGIGE?9?BG>DGC8BF3;@EGBEHHAEECD7;A><;;;;;@@B:@B9(,53:>ACAC@AAC9>><?A<
@041
ATCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGC
+
CCCFFFFBFHHFFEHI?FEFFHHEGHHICFBIIGGGIIIIIIIDHCAEGHBHFFDCEEDDDDDDDD>>BBBCDDDCCACCDDDCDD(9@<BB<CDCCC:AC
@042
CTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BCCDDFFDHGGGHHHGJIJJ@GHFHEGIJIIAGHIIJIIIIIFIIJJJIJGIIHGHHHFEFFBEAEECCEDEDDDDDDDDCDDDEDDDDDCCDDD@BBDDC
@043
AGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGTCCATCAGAGG
+
CC@FFFFFHFHHHIJIJJJJJJJJJJIJJGIHIGIIJJIJIIJJJIJIFIHGIJJJIIIIJIJIJJJHHEHGHDDDEDCBCACCDDDCDDDDDDEDDDDDD
@044
CCCCTTTTTGTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGC
+
?1=?D:BD>D?C:A,<AEBFEIE@EEEFF>A<<BEEE9*8?83?D3B9?DD><?28B@><B8BA>A=AA4)7@C7@DAC:C.?A).;).9>?=3>?A2,'
@045
GCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTC
+
CCCFFFFFHHHHHJIJIIIJJJJJJIJJIJJJIIIGIGIGHJICIEDGIJGJHIGIJJEIIGGGHGHCGEHGHHFEFBBDEEDCCCECCEDEDDDDDDDC@
@046
CCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGAC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJIIJJJJJJJJJJJJJIIJJJIHIJJJJJJJIIIJJIJJJJIJIIGIIJJJJJIJHGHHHFFFFFFFFEEEEEEED
@047
GCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACC
+
?<@DDBDBFFDFFF>FACE<I:A@CBA=;9FH9EFFEGEAC@F>C;DFFE=?F:AFIECEEFFBD3;@@@A>A(;;ABAB>ABBD@:ABBBAABBB<B5
@048
CGGTATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTTGCTGGGGTATGGCATAT
+
@@CDDDDFHHHFHIJJJJHGGEHHIIIIGEFHGHIJIJJIIIJJJJIGGHIGACEFHFFDDFCCCECDDDDDDDDDD?ACDDD@C@CDDD9>CDCBCDDC
@049
GCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTT
+
CCCFFFFFGHGHHJJJIFHIJIJJJJJJJJIIJJIJJJIJJGIIIGIJGJJJJJJJJGHIFHIJJJJJJHHFHHGGFFFCBEEEDDDDDDADDDDDDCDDD
@04A
ATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGAC
+
@BCFFFFFFCFHFFHEHIIJJJJJJJJJJJGHEHGIJJIJIJEHGIEEFHGEFDFFFFEEDDDDCDDDDDDDDDDDDCDDDDDD>CDDDEEEDEDDBDDDD
@04B
TGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTG
+
?@@DFFFFBCDAAFEGGGBFHHHDHGHDGHBGII@FDCFHCBB3DFHHCGIHEGHECAFAF@CGEB,5;BB9>C@>?49@C>@CDCC><>C?<8<<@BB
@04C
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJHIJJJJJJJJJJIJFHIJJJJJJJJJJJJJJJJJJJIIHHFFDEEEEDDDDDDDDDDDDD?CDDDDD
@04D
GAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATAGCAGCAACAGCA
+
@@CFFFFFHHHFHJJIIIIIIIJIJFGGCHGGIJJIGIIJJJJIIJIIJJIJIJIFEHHFFF@CEEDEEDDBBCBDDDDDDDDBDDCDCDDDDDDDDDDD
@04E
GGTTCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTT
+
@CBFFFFFHHHHHJJJJJJJJIJJJJJJHHIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJIJIJJJJIJIJIIJJJJHHHHHHFFFDFFEEEEEE
@04F
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@BFFFFFHHHHHJJJJIJJJJJGIJJJJJJJJIJEIJJJJIJJJJJJHCHIIJIGIIJJGIIJIHGFHFHGFDFEFFFDDD9?BD@CDCEDD>CBDDDBD
@04G
GGGCAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTG
+
C@CFFFFFGHHHHJGIJJJJJJJJJJDDDDDDDDDD>CDDDEEEDDDDCDDDDDDDDDBDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDCCDDDDAC
@04H
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
CCCFFFFFHHHHHIHIJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJHHHHHHHDDFFFCEEDEDCDDCDDDDDDDDDDD9CDEDDDDDDDD
@04I
CGGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTAT
+
CC@FFDFFHFGHHIJJJJJJJJJJJIJJJJFIGIJIJJJJIIJJJJJJJJIIJGHIJJIJJHIJJJIEHGIHHEHFFFFDEEEEEEDDEDCDDDDDDDCCD
@04J
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
CCCFFFFFHHHHHJFHIHIJJJJJJJGIJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJHDFDDEEDDDDDDCDDDDDCDDCDDDDDDDDDDDCDDEEDDD
@04K
CCGCTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHGHHFFFEEEEEEDDDD=BDBCDDDDDDDDDDDDDDDDCDDDD
@04L
CTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGG
+
CCCFFFFFHHHHHJJIJIJHIGJJFGGHJJJJJJCHIIJIJJJJIIIIIJ@FIIJJJIJJIIJHDDD>BDDDDDDD<BDDDD5<@DEEDDDDDDB9@BDDD
@04M
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGT
+
CB@FFFFDHHHHHIIIIJJEGGIIJGIIFIIHIJJJJIJJHIGGJJJJJIJJIIGEIJHHHGFFBFFDEDCEECCDDDDDDDDDDACCDDDDDDDDDDDDC
@04N
TGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
CCCFFFFFHHHHHJJJJJJJFHIJJJJJJJJJJJJGJJJJJJJJJJJJIJJJJJJJIJJJJJJJJJJJJJJJIJHHHHHF;BCCEDDCDDEEDDDEEDD
@04O
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
CCCFFFFFHHHHHJIJIIJJJJJJJJJJJJJJJJJJJJJIJJJIJJJIJJIIIIJJHHGHHEDFDFFEEEEEDDDD?CCDEDDDDDDDDDDDDDDDDDBDD
@04P
GGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATT
+
@CCFFFFFGFHHHIIJJJIIIJDAFGGGIDFFHJGGGJJGHHIGGHIA@FHIJHDDDD<5A@C@DCDDDDB8;BDDDDDBD>DBDB>BDBBDDDBDDDEE
@04Q
TACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAAAAAGTG
+
@?@FFBDDHHF?FHIIIIGIJIIGIIIGIIIIGIJIIGGGGEGGEGGGHGEGGEGIJIIJJDHFGHGGIIIJIJGEHIIJJHFDDCACCDDCDDDDDDDAD
@04R
GTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJJIHHHFFFFFEEEEEDDDDBDBDCCDDDDDDDD
@04S
CAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTC
+
BC@DFFFFHHFFHJIJJJJJJGHIJJJJIJJJJJIJJJJJJJJJJJJJJJJIJHHHHHFFFFFFDEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDCCCBD
@04T
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
CCCFFFFFHHHHHJJJJJJJHGJJJJJIJJJJHIJJJIGIJHIJJIJJJJJJJCHIJJJGHGGHGFFFDDFDDEDDDDDDDDDCDDDEEDDDDDDDCDDDD
@04U
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJFHHHIJJJIJJJIJJJJJJJJJJJJJJJJJHHFFFFFEEEDDECCDDBDDDDEEEEDDDDDDDDDDDDDDDDACCD
@04V
TGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTT
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJIJJIJIJJJJJJIIIIIJJJIJJJJJJJJJIIJJJIJHHGGGHHFFFFEEFDEDDDDDDDDDDDDDD
@04W
ATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATCATCGAG
+
+8?DD;DDDDDDDEEE>+<CCEDEFEEIEEED9EEIBADDDD0DCDBDEECCEB)=87@=@CCACE<@C=A;?>@;@;>BAA@A3>>
@04X
CTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCT
+
CCCFFFFFHFHHHJJJIJIIJJJJJIJJJIIIJIJJGGIJJIGHHIIIIIHIJJJJIJJIJJJIJJIJIJJIIJIGGIHFGFHGFEFFFEEDEEEDDDDDD
@04Y
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
BB@FFFEFHHHHHJJHGIIIJJJJIGIIGHJIJJJJJJJJJJJIEIIIIJJJJJJIJ@FHIGIIIJJFFHFFFFFFDCEECEEDDDDDDDDDD5;B9@D9B
@04Z
GTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCAT
+
CCCFFFFFHHHHHJJIJJJJJIJJJJJJJJJIJJJIJJJJJJJJIIJJJJJJJJJJJIJJJJIIJIJIIIJJJJJJIIIEHEHHHGEFFFFDEEEEEDDDD
@050
TCTGATTTGTGGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGTTTTGATTTTCAAGCACTGCCACTCTGTTTTCTAAACATTTCAC
+
=??D?DDDDDBDBBE:?,<CE:CEEDDF@9<21?E9E911:?CBBDDEA99?*9?9*?DDI9(8===8A@7)67@=ACC==ADD;;;@AA>A@66;>>D>;
@051
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
?<?ABDA@D?BFAGEFGHE>FHIBEEHI>3;DC79<BB2?BB<80B@HC<<BA=83=;226AE=ECCDC)?>>CCCCA>>:AA9::>:>@CB@BCB?(3&&
@052
CCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCT
+
@?@BADBDCF<DDIGEEH>GBD4C@G?CGGDI@FFHGHGIHEDAFFFHG<CHECEAH>=ECAABE@D@;<ABBB;<AC<?6>@@9>BBB:CA<@BB<<99@
@053
TTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCA
+
?@@ABADDFFD<DB?GFAIIGGHHGGGCHIIGGCCHIE:?F>?BG@9BF?BDFH?==@@CADFCD8FGH;=CEAC3?EEHCCEBD<CC@CCAC@@@;>@
@054
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAAC
+
@CCFFDDDFHHHHJJJJHIJIJJHHIFGIFHIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJGHHFFFFEEEEEEDDDDDDDBDDDDDDCD:CCBCDEED
@055
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACT
+
@@CFFDDDHHFHHHIIJIIIFIIIGIJJIIDGGDCHIJJJBGCHJFGGHGIIHHGHADDDDDDBDACDDDDDDADDCDDDCDDCCCDDDDDDBDCDCCDDC
@056
CGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTC
+
CCCFFFFFHGHHHIHHJJJJFHIIJJJIIJJJIJIIJIJIJJIGIIJJJJIIJJJIGIJJJIHHGHHFBDDDDEEEEDDDDDDCDDDDDDDDDDDDBDDDD
@057
CTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGT
+
@CCFDFFFHHHFHIIIGGCHGGIDIGGGGHG@CC>HCHG@GEEIIIIIIGFHIEGIGIIIBHGEHGCGBHFFFFF>A>;?B=BDCDC>CDDCCC@C4<?&
@058
CTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGAGGAGGA
+
@@@FDFFFDFHHGJIGIIJIFFHAFE?EEHHIGDGJGGEDGGDIG>FGGGICHGHFEDDCDCDDCDDDBABDDBCDA3@CCCCBCBCDCDBBDBBD?8<?
@059
CCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTG
+
CCCFFFFFHHHFHIJIGJJJJJGJIEHIJJJIHHIGGGIJIGIHIJJIJJBGHJIIGHGGIJIIHGHHHFFFFFFEEDDECDEDADD@CBBDDCDCCDDDD
@05A
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
@?@DBDD??F?FFFFGAEF;ACEBBH<;F@D??GHGAGDHAHCD@=;BGIGACCDAAHHEEHHCB?DCC>ACCCCB@232>C>ACC:?BB@@CCCCC:>>C
@05B
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJIHGHFFFFFEEEEEEDD9?B=CDDDDDDDDDDDDDDDDDDDD
@05C
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
C@@FFDDFFHHHFIIIIJJIIIJGIIIJIJJJIGGIJJGIJJJJIIJEIIGHIJJCGIIGJIIIEGIHHHGHFFFFFFFDDB9?BDBCACECCACDDBDDB
@05D
TGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGT
+
CCCFFFFFGHHGGIJIJIIGGIIIHJIIIJJIJJJJEIIJIDHIHIGJIJJEIEHCHHIGHHGHIJJHGGGHHHFFFFFFCCECECAEDEDEEEDDDBDD?
@05E
CCCTGCTCATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTTTGAGAACTATTTATGTACAT
+
?=?AB:=A,:A4?E9EEE+:BEFE@+A9AF9B<+?@EDD@?C?<BC?@::*0**:D*?D32?DBDDBEAC48=8@A4@;A).))@=>=CCA77;?>??6;B
@05F
AGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATGTGCCTCCTTCAGGAATTC
+
8;?DDDDDDCBFDCHI<EGCFHBFG>E>FHGHIIDFHBGFGHI@BHFGB><BDBFF@@2CD@=DGCGEEHFHHEHHDE@@CBE@AACCCCC>>@C>@CCA
@05G
ATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
CCCFFFFFHHHGHJJJIIJIIJJJIJJJJIGIIJJIJIIIIDGHIIJGHGHIIHGGBEH?EFDFFFCCEEDDDD=ADEEDDDCCDCDDDCDDDDDDBDDDC
@05H
GACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGT
+
@@@FFFFFGHHGHJJIIIGHGGGGJIJJCHIGGGIJIJJEEDFGCGDDAFGHIIJIJGHHGIHIIIIIJFIJJEIIJIEDHHFHHGHFFFFBECEDDECED
@05I
AATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJHIJJJJJJJIJJIIJJJJJJJIJJJJJJJJJJIJJJJJIJJJJIJJIHHHHHHHFFFFEFEEEEECDDCDEDDDD
@05J
CTAGGGACTCGAACAGAGACCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTC
+
CCCFFFFFHHHHHJJJJIJJJJJJIJIJJJJHHIJFHIJJJIJJJJIJJJJJJJJIJIGIJ;EHBFFFFFDDDD;ABBBDDDDDBDDDDDDDDDDDDDDDD
@05K
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
@@@FDFFDFHHFHIJJGEHIGHII<CFHEGFHFGE?DGEGIIIGIJJIJIIGHGICH4@EHHHHF>@BDCEEECAB>B@CCDDDACCDDDCCDDDCDDDE
@05L
ATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATC
+
@@@DDD2BFAFHFGIIIIIIIIIGIIIIIIIIIIIGIIIEIIGHIIIIIIGIHIIIIIIIIIIIIGIHHHHEBCCCCBBBBBBBBCBBBBCBCCCCCCCCC
@05M
CGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGT
+
@CCFFFFFGHGHFGGIEFGIEHHGGEEFGGIFEGIJGCHIJJJIFFDDDDCCCCDCDDDCCDDD-8BC@CCCA@CDEC>CDDC@>CBCDBDDD>BDDBB@+
@05N
TCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCAT
+
CCCFFFFFHHHHHJGEGIJJIHIHIIGHJIIIJJIJJEIIHIIIJIJJJJIIHHJGFCHHIJIIIJJJJGJJJJJJIJJHHHHHFFFFFBEEEEFEEEDDD
@05O
GAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCG
+
@@CFDDEFHHHHGJJJIJJJIJJGJJIIIIJIJIGGIJJJFHGIJJJJGIJJJJIIIJIJJHHHHHHEFFFDFFEDCEEDDDDDDDDBBBDDDDDDDDDDD
@05P
CGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGGAATTGG
+
<@@DD?BBB>BBFFAA<:AFGFFE9CCCFFEEDFBFGD>GEB?B999<@?8?;C>8C=BCA;=;@A=7C@@@D;>3);?==??@?3>A@;>;AB(5:<:>B
@05Q
CTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTC
+
@CCFDDDFFFHHHGHJIGIIGJHGIJIEHIJGIJJIJIJJBHGHIJEIIGIIIGBDHHEGGIIJJGGIIGGJIJIJIHFHEHFFFFFEFEEE>CEECDCD
@05R
CCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCG
+
BCCFDDFFHHHHHJJJJJJEIJJJJJJJJJJJJJJJJJJJJJJJJJJFHHIJIIJJJHHHFFFFEEEEEEEDDDDDDDDDDDEDDDDDDEDDDDDDDDDD
@05S
AAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTGGGGGTCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGAC
+
<<=DDDBDADHA+AEH@EEGGEHHHGHGEIAHGGGIIGIIAGHDHEHIGCG<8CFCEGGF4=@ABCCCCCCA@AA>@AD>(>CBBC>3?@AC:@@@<BBB?
@05T
CTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGC
+
??@DDDFDFFFHBDEHGGG?FHGHBBFGGEHEEFGIGIIIGHGGHGIIGIGGHDG=FGIEHDEEHEEDDEFFCCCEEE@>B?CA5>ACCACCCCACCCCC
@05U
CCTCAAACTCCATGAACCTTTCTGCCATCTCATAAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCC
+
CC@FFFFFHHHHHIIJJGIJJIJHIJJJIJJJJIIJJJJJGGIIIJJGIIIJJJGIJJIF7@@GHIIJIIHEFFFFEDECEDDECCDDDDDDDDDDDDDDD
@05V
CTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGAC
+
@CCDFFFFHHHHHIIGIIJJIJJJJJJIJHIJJJIIJJJIJJIGIJJJJJJJJIJJJJIIJIJJJIIJIIIJJHHHGHGHFFFDFFFEEEEDEDDDDDDDB
@05W
CTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTG
+
???DD;;DCDB?2A?B<?CE4AFB@F:+3<EE<2+1118C*??:?DEDD9?<909B?99B?;1=B))8@@C=)8))7A7.67.=A))..;?@7;>6>A6-5
@05X
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@@@FFFFFHHGHGJJIJGIJJJJIJGGIIIBGEHEGHIJJIJIJIJJIJIJIJEIHGGIHIFGGCEDFFFDDDEDBB;ACDCCCCDCDDCDDDDCCC?CCC
@05Y
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
@@CDFDFFHHGHHJIGHGIIIJIIJIIJIIHHIJJJJJJJEGGIJJIJIIJJIHJIJIIGIHIJJIJGHHHHDFFF@@CDACDD5>@DDDCDDDD@BDDDA
@05Z
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGG
+
<@<DDA@:1A<DFGIIIGGH<@H>H9?CDGICEGE<FDGF?G@F<?@DAGHC<A6AGGGICEACCCHEAH7;@BCCCBA>;>;;;@CCCCCCCCDD>>9;5
@060
ATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCT
+
@C@FFFFDHFHHHJIJIJJGGHGHIGGGGEGHGIFDHHHHIGIJIFGEABEFCEEEEDCDDDDDC:ACCCDFEFECDDBB?CBBD9?CDDDCCDDDDCDC@
@061
CTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCT
+
@=?DADDDHBH<FGIIIEHCGGGGIIIICHHGGGHIIB@DHGGIIG=FHGHIIHHGGDDDEEEEEECEDDDBD7?BB@BBDC>A>AACDCCCDDDDDEDC@
@062
GGGGGACACTGGCGTGCTGGATGGGGATTTGGGCTGCGTGCAGACGACGGGGTTGGAAGCCTGCGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACG
+
CCCFFFFFHHHHGJJJIJJJHIIJJJHIJJJJJJJJJJJJIJJIJJHHFDDDBDDDDDDDDDDDDDDDDDCDDDDDDDDDDDBDDDDDDDDDDDDDDDDDD
@063
GCCCCGTACAATTTGATGACATGTGGGTGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGAGGCGTTCTCTTTC
+
?@<DD>?DDDH8AD9CD<HCA>G?FHB??:FBBDGH@;;FGIIIIICFIGIIGIGEEEHEEE;CB;.>6;A;8;;:3>@:C<@@B7<<?<9>?8:@@>A
@064
ATACAATTTGATGACATGTGGGTGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGAGGCGTTCTCTTTCAGCATCT
+
@@@DDDDDHHHFDH@EEGHBHIC?@GFCEGGBGHHIGBHGBFGIIDHI@BHGEGGIDHGGIIEEF9A<<AACCC3>?;8;8>B<@BBB<CCCCCCCCCCCC
@065
TCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
@@@FDDFFFHHHFHGEHJJGIIIIBHIJGHGIJIIDGGIEAFCHIJIGHGGHHFHGFCDCC>CDB9@CCCDCDCDDDDCDDCDBDCDDCDDDDDDCCD4@>
@066
CTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGT
+
CCCFFFFFHHHGHJJJJJJJJJJJHIJJJIIIIJJIJJJJJJJJJJJJJJIJJJJJJIIJGJIIGIJIIIJJJIJJJJJJJJJJIIGGHHHFFFFFEEEE
@067
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCAT
+
CCCFFFFFHHHGHJJJJJJJJJJJJJIJJJJJJJHHIJJJJJJJJIIIJJIIJJIJJIJJJJJIJJJHHHCEDACC3?CDDDCEDDDDDDD@BD@CDDEE
@068
GGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGAT
+
CCCFFFFFHHAFHIJIGHJJJJJJJJJJFHIJIJFHIJIJJIJIGJIIIIJJJJJIIIHJIJCGIIJJGGIGHECHHHFFFFF>A>@CEEEDDDDDDDDE
@069
CTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAGCCATGGGGGTAC
+
@@@FFFFFGHHHGIIJJJIJJJJJJIJJGJGIIJGIJJJIHIJJJJIIIJJJIIIIIIIJJJJHHHFFFEEEDCDEEDEDDDDDDDDDCCDDDDCBDD>BC
@06A
TGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGAC
+
@C@FFFFFHHHHHJJIIJJJIJJJJJIIFHGIIJIJJIIIJJJJIJJEFGIJJJJJIGIIIJEHGIIJIC9A66',',,(6(-;>(,8=B>&&0(+3+(3<
@06B
GGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGC
+
@@@ADDDFDHHBDHEHIHIIID@DHGIIIIIGHIEIIGBGIIIIIGGIIGEHFDDCCBEDD=?@C?CBBBDDDDDDDDDDDD39<AD@@@BDDCCDBAB
@06C
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
CCCFFFFFHHHHHIEGHFHJJJJIJJJJJJJJJIJJIIJJIJJJJJJIJJIJJJJIIJHEFDEEEDCDDDDDDCDDDCDDCCCDDDCDDDDD?CDEDDDD
@06D
TCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGGGGCTCCAGTCTCCCTCCTGTTTGCACATAGTTTAACACATCA
+
@@@DDB?D;?FDHIEEEHG@?AHHEGIEHIIIGGIGGIGAHGIG>EHIFHGIFHGI(<FGFEH@CDE@@DCCC??CCCCC<C@CCCC@D;ACCCC@CCC
@06E
GTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCAC
+
;=?DDDDD?FFDBCF@GGCGHHGEHFHC@HGEC;<EGHIIII@DDGC3DDBEGD?DEGB)=CGII>FECDG>G>EEHFDE>AAEBCBDEECDCCCCDC@BA
@06F
CTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
@<@A??DDDD<CBFBHIBE>DHHHHIHGIIIEHIHI?DGDGGIEHDBD>DGCGHGIIIBI?HCHEHI>>EAAFF?ABCE>@C@C=;@C8=?@@BCCCC
@06G
TGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@@FFFFDFDDFHBFHIGAGFGHEGFHGEGGE?FFDFGIJJJIJGHIFGHGHDBFHGGGIG==.?CEEHDFFFDECCCACAB>CBB<CBDDDDDD<<(2>
@06H
CACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCAC
+
CCCFFFFFHHHHHJIJJIHJIJJJJJJJJJIIJJJJFHIJJJHGHGFFFFEEDDDDDDDDDDDDDDCEEDDDDDDDDDDDCEDDDDD>CCDCDDDDDDDDD
@06I
CTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTG
+
?@@?=DDD>F>FFBBGEHEGGIIGHGEBC?FFAGGBAFGFHDFDHIIIBGCGEHGGG=@GGGG3==DCEFFEHGHDFEBCEA>A;5@-;=<BA@CCCDDAC
@06J
CTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCG
+
CC@FFFFFHHHHHJIIIIIHIJJJHIIIJGIJJJJJJGIIID>@?@CDDCDDDDDCADCDCD?BCCD>CDECDDDDD@CCCCCDD
@06K
TTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTT
+
@@@DD=DDBHBFHIGHGIIIIIICHIGIIGII<CDAHHGIIIIII>FBDEFDHEHIIHIEIIIECHAFHIGGIIHHHEHHEFHBDFFDFEEEEEAEEDDDD
@06L
GCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCT
+
@@@FBDDFHHHHFHGIGFHHEEHIJJHGEEEHGGGHIE?GGHJBGGIEGBGBFGGEHGHDG@FDCHBGFGH>C;DGGDEHGCHHGFFFFDFEE@>ACECCC
@06M
CGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATAC
+
CCCFFFFFHHHHHJIJJIJJGIJJJJJJIJIGIJJIJJJJJIJJJIHFFFFDDCEEDDDDDCDDDCDDDDDDDBBCCDDCCCCCDDDDDDDDDDDDDCDDD
@06N
CCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCC
+
CCCFDFFFHGADFHGGIEIIIGGJGDHGIIJIIIJIIIIIEHIJJCHIJJIIGGHHIIFEEEEDFFFFDCCECABDDBDDDDD:@ACDFDDACDDDDDCCD
@06O
TTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGC
+
@@@B=DDFHHBDFGGIGICHD<HE<<CHHIGGGDG?DCAEDAFGIIIIFHEIIIBC@GHD=D;CEH=AHHGG?@=BCEE@CCCCCC@=?A>>CC5<<9
@06P
CTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTT
+
CCCFFFFFHHHHHJJJJJGGIJJJIJJJJJIJIJJJHHIGHGFHIJJJJJJIIJJIGDHIIJJHHHHFFFFEEEDDDDDDDDDBCDDDDDDDDDDDDDDDD
@06Q
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGGGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
@<@DDDDDHFHDDEGBHIFGAFHHIICHGAH>>;BF**??DC?<DAFFH:@DB@CD=AG':8>;;>5@>55:5@CC?:<85:>44:>A@A4<BAB3@ACC>
@06R
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CBCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJIIIJIIJIJGIJIJJJJJIJJHHHHHFFFFFFFDDD9?BD=CDDEDDCCDDDDDD
@06S
TAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCC
+
8??DAD?DDDDD;<A:CEBFE)070&+>>8><7-8<>>>88(83>>3382795==A:AA(3:>>>:>A1::43>44:(:>>>((((8>>?A>>2>>34>A9
@06T
GGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGC
+
??;D??D?<:<D?<AFGBF?AF@G::?C:?DG8?0?B??<FBFA9?B?DDF6A6@@@7=77).=AECEDC?>>@(9=??,<:@B>AB>ABBA:>:::AA>A
@06U
TTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGC
+
CCCFFFFFHFHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJIIIIJJJIIJJJJGJJJJIJGIJHHHHFFFFFDCACEEDCCDDFEDDDDDDDDDD
@06V
CTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCAC
+
CCCFFFFFHHGHHJJGIJJJJJJJJJJJJJJIHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJHIJJJHHHHHHFFFFFFFEECEEEDD?BDDDDDDDDD
@06W
GTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCT
+
@@@FDB??HFFHDGG@AEGEDHIAHIBII9D?FF@FEGHI?DGHECHGI)0@;@F@FHG<HIIGEHE<<5>;@ABBBBBA@:AACCCCACCC>>ACCEECE
@06X
ATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGC
+
@CCBDDDDHHAFDGIJJJJIGIIIIJIIIIFIGHHIHGG?DHGGHGIJJAFEHIIGEEHFFCEFEEACEEEDDBBB@CD@CCCDDDD>>BDDDDDDDCDD
@06Y
TGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGC
+
@@@DDA??ABDCDGHFIE3FF@FGGCC9AEFHGGDGEH<B?DGCBFDHIHIG89BFG8BGF3==FHGGH<7@<-;@B@C:;;;;>6@(;;@@CBBBC=@?<
@06Z
CGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTC
+
@@CFFFFFHHHHHJJIJJIJIHIIJJJJJJJJJJJJIEGJJFIGIJJJJJIJJJJJJHFFFDEEDEDDDEDCDCDCCDDDDDDDDDDDDDDDDDDDDDDDC
@070
CTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTG
+
BBCFFFFFHHHGHJJJJJJJFCHHHJJJIJJJJJJJJJJJJJJJJGIJJJJJJJJJJJIJJJJJJHHHHHFFFFFFFEEEEEABDDDDDCDDDCDDCDCDC
@071
TAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCC
+
@@CFFFFFHHHHHJJJJJJIJJJJJJIJJJJIIJJIJIJJJJJJJJJJJJJJCGHIIJJHGGGHHFF@DFDDDDDDDDEDDDDDDDEEDDDDDDDDDDDDD
@072
GGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTG
+
@B@FDFFFHHHGHJJIHIIJJJIGIJJJJJJIJIJJJJIJGIGIJJIJJIBGHGIGIIJJJGHIJJHFDDCCDDDDCDCDDDDDD<BDDDDCDDDDDDDDC
@073
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJHHHFFFFEEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@074
TCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCT
+
<@<?DDDD<FFB:E9?E<?C;?:<33<FFGH@+:1CGF99?BC<CB90?*:??B98)/0B*B)=B48)..7>@4@).7=CEE>E===)77.;3.)(;@6(;
@075
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@?@DBDDDDBHGHIGGIHGDHIDHGIGGGIIIFIIIGIIDGHDHHCHIIDFGHFC>FHEGGCCEHEHHB>A?CCDFDFFDD:,8?@3:?ACACACDBDDDB
@076
GCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCAT
+
@@@DFDFDHBDFHGIDHFCHIGGCCFGIGDIIICHGGBBBDDDDCCD3>A3@@DEDCCDCCCB8@B?A?BCCDCCDCC@?>:A<CDDCCCBB<B9CACBCC
@077
CGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTT
+
<?<?BDDADBD+++<:EAF;BEB>EECEDDEDD91?D?@??BD???DCAECC887)8@CCEE>CCCA:54;???3;;A;>=????A=9<<?>:(:ADDDA?
@078
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJIIIJIJJJJJJJJJIJJIJJJJJHHHHFFFFEEEEEEEDDDDD@BDDDDDDDDDD
@079
CCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGG
+
@@@DDDDD>FCFDGFH@BFGDG?<HCHH<FHEGEDGEEDD>?@9?FFEGCFEHIGG@@B<CE=CFFHGIIIIIIIIIG3?E?CHDEEDEEECCAAC@CCCC
@07A
ATTGCATATAATGATACTCTTCCCTCTCTTTTTCCCCACAGTAGAGGCAAACTTGCAAATGTTTTCCAAATACAATATGCCTTGCTTCTGTTCACAGTTC
+
@@@FDDFFHHGHDID:2A+<EBEGIIIFHIIIFHIIHIGIGFHFHDDHIIIIIFIGIIHIICFHIGGHIIEGHID>CEFHHHGFFEFFECDCECECCCCC
@07B
TGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGT
+
CCCFFFFFHHGHDHGIJIJJJJJJGHGGIJIJJIEGIJIEGHIGJGGIIJJJJFGFIIIJGGIGGECHGIGGEHAAHDFDDD?C@CCDCDDDDDDDDDDA
@07C
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTC
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJIJJJJGGIJJJJJJJJJJJJJHHIHGHHHFFFEEEEEDDDDDDEDDEDCCDCDDDDCDDDDDCDC
@07D
TGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTC
+
CCCFFFFFHHHHHJIIJJIIJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJHFDDDEDDDDDDDDDDDDDDDDDDDDDDDDEDEDDDDDDDDDDDDDDDDDD
@07E
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
@CCFFDEFBFHHHJJICHGI8EFHIJJIJJIJ>GEGIIEGEHEGGHIJIJGGI=DDGGHDHHGHGFFFB@DCDCDDDDDEDDA@CDCDEDDDDDDDCCDCD
@07F
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHGHJJJJJJJJJJJGHIHIJJJJJJJJJJJJJJIJJJJJJJJJJHHHFFFFFFCEEEEEDDDDDDDEEEEDDDDDDCCDDDDDDDDBDDD
@07G
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJFGIIJJJJJJJJJJJJJJJJJJJJJJJJJJHHFFFFFDEEEEEDDDDDDDDDEEFEDDDDDDDDDDDDDDCDDCDD
@07H
GGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGT
+
BCCDDDFFHHDHFIJIJJJJIJIJJJJGIIIJIJJIJJIJJJJGJJJJIJJJJJIIGIJGIGIAHEDHGIFHHFFFDCDEDDDDDCCDBCDDADDDDDDC
@07I
GTATGACTCTGTCTTTTAAAGTGTTCTTATATCCTAATGTTTTTTCCATGCTTATACTAGAAATTCCTCAGTACTTAAATTTTAAAAGAATAAAACAAATG
+
@@@DDDDDFFDA?EDDDGFA@3A<A<AE<B?AE<F@F9?FFGIDFCFDFCACFDFBDFGABCFGIFIGIEEF>@EEEFEFIFEFFEFDBDDDB;>>@@BB:
@07J
CCAGGTGATACAGCTGGTGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGCTGG
+
BCCFFDFFHHHHHJJJJHIJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJHHHGHFFFFFDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@07K
GCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGACTGGAGCTGCAAATGCCTTCTTCCTGCTGGTCTGTTAGGGTCTTCTATAGAATC
+
???1BD?;DD8::CDEDE4FEEEFE4<AD?E+++*:C<BEA<@*:C)B?<)?))90?DDBDDB8=4=B7).8=@A;=)7??AC;A@@ADAAAAA>@DA;(;
@07L
GGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACT
+
@@@BDDDDHHFCFGGHIICHIIIIIEHGFFDHIIIGGEHGHGIIBFG=FF<DDAE?CCC;@DDCDAB?AB;A??@::5:>5:?CAB@?BB??9><<BBCCC
@07M
AGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGT
+
@@@FDFFFHGHFHJJJIIGIFABHGGIBBHGHIIIGHIFIGIHHGGEIGHFHIEHFF=FGI>GHHEAEHFFFFDEECEEED=CCDAABD(:?BDCDDCDB@
@07N
ATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAA
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIIJJJJJJJJJJJJIJJJJJJJJJHHHHHFDDDDDDDDDDDDD
@07O
CGCCGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATC
+
8=?D;D@DDBAC?EDI@??AB2CE?EEC?DEDIEDED9DD??@D@B<8DE@43==BDECDD@DC@87@DDDD@;CCC;CD;;>AD;;>A@AAA?>,53'5<
@07P
GGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTAAGGACTGCGATGGAGGGAGGTG
+
@C@DDFBD>AFFHIIIBECFHIGEHIFFDEIIIICHGIIIGHGHFDD?CC@@CDDCDDDCDDD8?BDDCD@CDC@C@>C@AAD<AB?B>BBBAABD9<B8A
@07Q
GTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCC
+
@?<D=ADD>F??<DF?FHHH@ADIGEHHDEHGBHGIEHHI?CD@HBCFHDB@BDB@F>?FGIEGHEH<=CDDE;@GEDA@DEGGHCEHEFHHEB:?@D@>A
@07R
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@@?DD>B?2CAADGB;<E::CFB:F)1:?::?BBFBGE9?FB:F;=FC;===A==C>E?9?7@;..6>>>A;A;>>D@>AABBA>AB>A@B@ABBBABBB?
@07S
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGGATAGCTGACATCAGT
+
?=?DABD=CF<BFEFB:CF<CF9:AG7FFCF9EFFEGFEF<FGEEBFC@9FAFAEFIIFAE>@@7?@2;A;>@;5>=(>AB9?@B,,)3+>>A:?4>4(>+
@07T
GTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAAT
+
CCCFFFFFHHHHHJJJHIJJJJJJAACCHHJJJIJJJJIIIIJJJJJJJJJJIJJHHHHHFFFFFFFEEEEEEDEDDDDDDBDDDDCCDDDDDDDDDDDDE
@07U
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
@@@DA:DDDFH?FGFIIGA:3<FEEGGIICI?G?CGCF>HE@G9BBBHCHBGHIF;)-@@EH:;=>@?CEE@>>CCA3;?,;@:;>CCCCC?@??C:4:@C
@07V
GGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGC
+
CCCFFFFFHHHHHJJIJJJJJJJHJJJIJJIJDGIIIJJJJJJIHGIIJJJJJJJJJJJJJI6@GIJJHHHHHHFFEFDDDDDD?BDDDBD@CDDBDD
@07W
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAAC
+
CCCFFDDFHHHHHJJJJIJJJJJJIJGHJCGIJIIJJJIIJJJJIIIJJJJJJJJJJJIIJJJHHHFFFF@CEEDEDDDDDDDDBDDDDDCD:?CCDDDDD
@07X
ATCCATCTCACTTCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAGCCATGG
+
@;?DDDDD?DFHHHHHGBGHDGCFCAFCGECFGB;C@FEA>FF>DG?8D?B@3=FFHHGDHEECGECHBH<B<;=65;>>A3(-5:AC>CC>CCCCCCCCC
@07Y
CACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACG
+
CCCFFFFFHHHHHJJJJJJJJJJJFHIJJJJJHIJJJJJJJIJIJJJIJIIHHBDDDDDDDDEEDEDDDDDDDDDDDDDBDBDDDDDDDDEDEDDEDDDDD
@07Z
GCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTC
+
@??D??BDFHAFAD<E?@EICB<F<CEEHHDH@@H<E:???<CD?::?:?FH4?9BGIGI>GGGC8?B<9BFH:FGHAFD;@=77@EH=@DC@;?@CA>>>
@080
GTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGG
+
@C@=DDDDGHHGHEGGEBGCF@FHBGFHEHIIEBGHIEHHCHIIGIHGGIIIIGCH<9BGHHGIICHGGIGCHEIGCHIIEDHFFEEF@@DCEEECCCC
@081
TTCTGTTCTCAGCCTGTCCTTTTCTTTTTGAAGACTGTCAACTTTTTCTTTTAGCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGG
+
=?8=BA2:C>DB?AFE@3<CEHI<A?CE+@;E<<C?F9BFGFDFEF9DCDBBGIEFB'@F4=)=7@C;CEE;7AA=AC77;@B:@BA>>;@:6;>;@>A9;
@082
ATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTT
+
@C@DFFFFHHDHHIIJJIJJGGGHIJJJJIIJDHIGEEHGIGIGIHHGJEIIJIJHGIIJEBHHJIIJJJJHHIIIIICCCHF>EEEHFFFEEEEEEEEEC
@083
GTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTC
+
@@@DDADDHDDFFCDHHEDHIDDD<FBFD???DDHIB@FAADAHHCHB@C?BEA@66@CC>BC;>@;?@:B:8;<<B@DDDA@AACC>:?AAC3?@88AB@
@084
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
@@?BBDDDBDFBHADG@DFE:CF>BF>F3D??;B9DEG@FDBFBFFDGCA@EGEH;?CDBACBC>ACCC3?@:8>C@:@CBBCCCCCCC2+0?>CCC>>CC
@085
CTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJGGJJJJIJJIJJJJJJJJJJJJHHHHGFFF?AACDDDDDCDDDDCDDDDDDDDDD
@086
GGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCT
+
@@@DBDDFGDAHHI@GGBGIIGIAHGIIIEGDGGGGG??FGHGFHIGHFHG>BDBBEECCCBC:AABBBBC@8>CBCACC>A>ACDCCB?BBBB99BBBCC
@087
GCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTC
+
C@CFFFEFHHHHHJIIJJJJJHHHHIIJJIJJHIJJIIJJJJJIBGHIIJJJJIJIHIJIHGHFHHHFFEFEEEDCECDDDDDDDDDDDDDDDDDDDDEDD
@088
CCCAAGGGTCCCGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCTGTGCATCCCTCTGGG
+
CCCFFFFFHHHHHIEHGIJJIJIIIJJJJGIJJJJJJJJJJJJJJIIIHIJIIIJIJIJJHHHFBBDDDDDDD>@CDDDDDCDDDCDCDDEEDDDDDCDDC
@089
TTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGAC
+
@@@DBDDDFHHHD@EHGII@DGIGIIGGGGGIIIIHGHGFCCCCD>CACBC>?CCCACD@CCCC:>ACCCCCACB@BBCCCCCCCCCCCCCBBC<CC:>CC
@08A
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
@C@ADEDDHDHGHJJIJJJJJGIIGIIIJIIGIJGIJJJJIIIIIGIIIJCGGIJI5ABFFFDCEEDDDDDDDDCCCDCCCCDDDDBDDDDDDDDCCCDDD
@08B
ACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCT
+
<@<DDDFFHHFDFHIGIIBFHID@EDFEGBG>GHG>;@<DGG=FFGF.;DCGC@E>EEEE@BB.?>CCECCCC@CCC@CCBC@C@C@B@?BACCC@@CAC8
@08C
AGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTT
+
CCCFFFFFHHHHHJIIIJJJJIJJJJIJIIIJJJJJJIJIGIJJJJJJJIIHIIJJJJJIIIIJJIHHHHHHFFFDDDDB@<@DCCCCCDDDDDDDCCD<B
@08D
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
CCCFFFDDHHHHHJJJJJJJJJJJJJJJJJJIJJJJHJJJJJJJJJJJJJJJJJJJIJJJJJIJJJCHIHHHHHHFFFFFFFEEEEECDDDDDDDDDDDDD
@08E
GTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAAT
+
CCBFFFFFHHHHHJJJJJJJIJJJJJFFGIJJJJJJJJJJJJJJJJJJJIJJIJJJHIJJJJJJJJJJJJJHHHHHHFFFFF@CEEEEEEDDDDDDEDDDD
@08F
ATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCA
+
@@@DFDFFHBFHHGIGIIGGGIJDFEHIJJIHGDHIIIJIJJGGGGHIIJJGHIIIJDDGHGHHIJCBHIIJJIE;@AGEHEHEHFFFFACDBACD
@08G
CCGGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCT
+
CCCFFFDFFHHHHJJJIJIJJJJJJJJJJJJJJJJJJJJJIIJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJJJJHHFFDDDDDBDDDD>CDDDDDDDCDD
@08H
ATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJIJJJJJJHHHHHHFFFFFFEDEEEEEDDDDDDDDDDD
@08I
CTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
@CCFFFFFHHHHHJJJJIJJJJJJJJIIJJJIJJJJJIIIJGGIJJJIJJIDFHJJJJJIJJGJJJJJJJJJHHHHFFDD;ACDDDCDDDDDDCDDD9CCD
@08J
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATC
+
CCCFFFFFGHHGHJJJIJJJJJ@HGFHGIGIIJJJJJJJJIIIJIJJJJJJJIHHHGFFFDFEEDDEDEDDDDDEEEDCDDDDDCCDDDDDDDDACDDDDD
@08K
GTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGGACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGA
+
1+:DB3:BB:C@DGGII@A9A9AFE@;C<D@FDGG<DG(8(BF)))/.5@<=C>?=?7B??3;;;>,5;882853<1252<AB@82??::>4?<+82::@
@08L
TCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCC
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIIIJJJJJJGHHHHFFFFFEEEEEEDDDD
@08M
GGCCGCTTAATCAGACCCATCTCCATATCCACTGTGAGTGAGACAGGCATAGTTCAGGCCTTCAGGCTTGCCAGAAGGGCAGTAAGCCACTTGTTTTTCTT
+
CCCFFFFFHHHHHJIJIJJIIJIJJIIIIIIIJJIJIIBFHHIFJIIIJJJIJJIIHIIJJJIJJIIJHHHFFFFFEEDDDDDDDDDDDDDDDDDDDDCDD
@08N
GTCGTGGTGCTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGC
+
BBCFFFFDHHHHHJJJJJJJJJIJJJJHIJGHIJFIJJJJIJJJJJJJJJJJJJJIIJJHHHFFFDD?ACDEFDDDDDDDDDDDDDDDDDDDDDDBDDDD
@08O
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@@=DAADAB?DD<FHGFDHIGI@D?D?G;G9F9CGI<9?BBFGBBDDDBBGIGE<88CA7(7=DCEC>3A;;B>?@B?CABBB?=?CCA>CC::(8<2)<
@08P
CTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTT
+
@@CFADEFHGFDFHGGHIJJIGIIGIGIJJGHBFGGIGHEIJGJFG=E?BEFFFEDCEDDDDBBD@BDCCDCCCCCCCDDCDCCDDDCDDDDCDEDEEEEE
@08Q
GTGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTTATTCTCTTCCAC
+
C@BFDFFFHHHHHJJJJJJJJJJJJIJJIIIIIIJJJIIGHIJJJJEHIHGHIIIIJIIIIIJJIGIGHIIFHHGEFFFFFEEEEEDDD?@C:@ACCDDD@
@08R
CTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGG
+
CCCFFFFFGHHHDHIJJJIIJJJIJJJJJJJJJIIIJJIJJHIJJJJJJJIJGIHHFFFDEEEDDCDDDDDDDDDDDDDDCDDDCCDDDDDDDDDDDDDDD
@08S
TCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTG
+
CCCFFFFFHHHHGJJJIJJJJJJJJJJJJJJJJJJIJJJJJJIJJJJJJJJJJJJJIJJJJJJHHHHHFFFFFFDCDDDDDDDCDDD@CDDDDDDDDDDDD
@08T
TAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGT
+
@CCFFFFFHGHHHJJJJJJJJJJJJIJJJIJJJJJJJIJJJJJIJIIJJJIGHGIIHJFFIIJJGBGHIHHHHFFFDDD;@A?B:?BDBDDDDDDDDDBD@
@08U
CACAGCCACTTGCAGGGGGCTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTG
+
?8=:+:BAC?FFAEFIAG<10)?DB0907?8=@FCF@=)8;5:=B13?;26;@55;;A@@ABB<@;??8?9@59@92:?19<?B228?B@3-83(:A?+8
@08V
GGTTTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCT
+
CCCFFFFFHHHHHIJJJJIJDHHHIJJJJJJJFGHHIIFIJIJIJIJJJJJGHHGDFDDDDDCDDDDCDDDEED>CCDDDEEEEDD?BDDDDDDDDDEEED
@08W
CACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAG
+
@CCFFFFEHFHHFHIIIGIJJIJJIGGJJIGIIGJGGGHHGIDGHJGGIBFFHJJJJJJGHHHHHDFDFFFEEEEDDDDDDCDDDDDDDDDDDDEDEDD
@08X
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAAC
+
B@CFDDFDHHHHHJJJJJJIJJJJJJJJJIJJJJIJJJJJJIJJIJJJJGJJJJJJJIHHHHHHFFFFFEEEDEDDACDDDDDDCCCDEDDDD5<BD<CDD
@08Y
TCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTC
+
CCCFFFFFHGHHHJIJJIJIIHHJIIJJJJJJJJIIGIIJGIJGIJJJJIJJIJJJIIJIJIJIJJJJJJJJIIDGIIJGGHHGGFFFFEEDEDDDDDDDD
@08Z
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCT
+
@@@FFDDEHHHDFG2AEFDHGIIIIIEHEIGEFGGGGIIDHA=GHIHGIIGHFHGGEGFEHGEIGGIHGFBBBBC@>CAC:?CDC:CDCCCB>@CB?BBBB
@090
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFFFHHHHHIJJHGIJJIGJJJJJDDDDDDDDDDCCDBCCDEDDCDCCDDADDDBBDDDDEDDDDDDDDDDDEDDDDDD>BDDDDDDDDDDACD?
@091
TTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCC
+
@@@FFFFFHHGHFJJJIGIHHIIJJJIJJJJGGFGGGGIIHHIGHFCHIIJJEHEGIIJGHJJEHIIIIIHGJGIIHHGH@CDBFFECEECCEDCCCCCD
@092
CTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGGGGTCTCTCATCTCTTTTCTTTTTGAGG
+
@@@DFFFDDHHBDBGEGHHIHIGIGIIIGIIGGIDIIIIIGIIHGIC>AHFA@EFDB?D:@CACC@BBB@BAA(5<09A>:A>AA::@CCAADDDDDD?BD
@093
CTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGC
+
@CCFFFFFHHHHHJJJJJJJJJJIJJJJJJJIIJJJJJJJJJJJIJHHIJJJJJIJIJJIJIHHHFFFFFCE@CCEDDECDDEDDDDDCDDDDDDDDDDD
@094
CGTAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
B@@DFFDDFHFHGJJJIIIJFHHIIJGHGHJIIIIIJJJIJIIIJFJJIIIIGHIIIJJJJJJJJIEHHFEHHD;@AACCDBDDD?BCDDCDDDDDDBCDD
@095
CCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGG
+
????BDDB?DDDDEDEI8FE82A9C@8EDDD@)???DD?BBDCE@CCCBA7=A1==;=4=CC=(,3,8=(<?>>:>;>A>5:::3>4(+9<9<<>>?+:>8
@096
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
?:;BDDDFGHAB?CFGFGIIIGEHFHIEIIIGCHC?<?F@GH;?DHI9FG;FGIIBDHGFEDA)=BH5)5?;@CEECD5;:AC>ACA3>BB<?<:>CBBB)
@097
GGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCT
+
@<@FFAAEBF?HDGEEEGGEDHHGHHGECBAFG@FHEGGIAAC@6@@DBF>DGCGH(=@A@>@).:=79<CEE>A;;==83(5;@<CC:>599?A@CA3>3
@098
AAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCATG
+
@BBFFFFFHHHHHIJJJJJIJJIJJJJJJJJJJJJJIJJJJJJJJJJIIIGIJJJJJIJJHHEHHHFFFFFEEEEDDDDDDDDDDDCC
@099
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHHHHJJJJJJJHIJIJIJJJJJIJJJJJIIIJIIIJIJIJIJIIHHHHHFFDDDDDDDDDDDDDDDDDCCDDDDDDDDCDDDDDDDDDDDDD
@09A
TCTCCTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGT
+
@@?DDDDDHHHBFIGGBH3FEHBFHFHCHGC9EBGHIIIGH@BABGBDD?DBFD@8=BFGBHHB@@>8?CC99A?8(4:@:::>><@3(::C>CAC><88:
@09B
GCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
CCCFFFFDHHHHHJIJIIIJJIGIJJIJJIIGIGIIJJIIJHJJJJGIGGHHHHFHFEFFDDDDDDACDDDDDCDDCDDDCDDDDDDDDDDDDDDDCDDDD
@09C
CATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTC
+
@<@DAABDFHHHDA>BBFEF@FBD@GGGAC9??BFHB@B3?3F<=F<;;FFCDEDCH;77?>?;@:;?>B(6;(.;>>5;>>5959>:95<59?(5><08:
@09D
CTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCT
+
CCCFFFFFHHHHHJJJJJIJJHHFHJJJJJJIJJJJJJIJIGIIJJJJJDGGIIDHGIIJGJIIJGGHGJJJJJJJIEGIHFGGEE@CEBDEDEEEDDEDD
@09E
CATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGC
+
?@@DDDDDHBH???AGHD@?FECE@GDEE?:D<?F>G@BGE@09B??FGD<?(878C;=F9((6666=AEE@)?;B>@6@@C@C>>;AB5,5555(,:(83
@09F
GGTAATGATGTCGGGGTTGAGGGATAGGAGGAGAATGGGGGATAGGTGTATGAACATGAGGGTGTTTTCTCGTGTGAATGAGGGTTTTATGTTGTTAATGT
+
?@=?BDDDFDFFFIIE<@8FGFIDFDFCBDFBFBB>DFFII8;DEF.=?CEFDB@;@@CCCC5;;?@?>A>?8?9?@:@@:@AB8???BBBBBB<?BBAB4
@09G
CCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATG
+
CCCFFFFFHHAHHJJJJ?FHIJJJJGIJJGIJJIJGIJJJJJJJIJJAHHGIIIJJHHHHDHFFFFFEEEEDDCDDDDDEDCCDDDDDDDDDDACDDCEED
@09H
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATAT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJHIIJJIJJJHIIIJGIIJJIJJJJJJHHHHHFFFFEEEEDDDDCDDDCDDDDDDDDDDDDCDDD
@09I
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@CCFFFDFHHHHHJJIJHIIJJJJJIIJGIIJJGIIJJJJJJIJJJJJJJJJJIIIJJHHHHHFFF=@DDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDC
@09J
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFGHHHHJGHIJJIJIJJG@CG@FHIGIIIIGIJJJJJGGIIIJJJIJEEHFFFFFCEEDDECDACDCCDDDDDEDDDDDDDDDDDCDCCDACCD
@09K
TGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATT
+
?+=BADAD:C,<CFFF@BEE>?:FFE:C@<+4AF<A3CFB99?D****??<9?9D)?9??D**/*/=@=>FFIIE4=DEFFIICA?:A)77;BDED3);6@
@09L
GGCCCCTTTTTGTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCG
+
CCCFFFFFHHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJIIJIJJJJJIJJJJJJJJIJJJJJJIJIJJFHHHH?EEHFFFFFFEEEEEDDDDDDDDDD
@09M
GCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCT
+
CCCFFFFFHHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJIJCGIHHIJIIJJIGJJIJJJJJHHJIJJJHHGFD?BBDDDDDDDDDEDDDDDDDDDDDDD
@09N
CTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTG
+
@@@DDDBDFHFFF@G?GBEFHHHIGHHIEGGIHCFEHGIDED?FFG<DHGH<?DDFEGBDF<CEGGGEH@;FHIGEGG@CA==;C=;@@CCBCCC@ACC3
@09O
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
C@CFFFFFHHHHHIJIIJIIIEIJJJJIJJJJDDD<FAHIJBGIIHIGHIGIJGIJIJGHIGIIJIHFEHEEBDFEECCC@CDDDDD8?BB9@CDDC:ACB
@09P
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
@CCFFFFFHHHDFIIIEBFHIGIIICBHIGHGG6?DGDHHGIIIBFGHICHIGGIGEGHEHEHHFF<ABCACDDDDB;@CDCDDDBBBACDDDCDDEEECC
@09Q
CCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAAT
+
CCCFFFFFHHHGHJJJJJJJJIJJJJJJJJJJJIJJJJJJGJJIGIIJJJIIJJJJJIIIJJIIJJJJJIJEGIIJHHHHGFEDDEDDDDDDDDDDDDDDD
@09R
GGCTGCTTTCCATAGGTGAAGATCTCCCAGAGGATCACCCCGAAGCTCCATACATCACTCTCTGTAGTGAACTTCCGGTACATGATGCTTTCAGGAGGCAT
+
CCCFFFFFDHHHDEGICGIJIIHIJIJJIEHIIJGIIGJJJEHIIJIIGICGEGIGCGGDCEHIHEHEFHHFFFFFDDBB@CDDDDCCCDDCCDDD@BDDD
@09S
CGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
@@@D<?DDHAFFBEE<C8C@?HFGCGG<GCFF0@FBHBBDGGIEIIBHGI>FCCDEEGECEEEEEB>ACC:;AA@?B8=BBA>C>>>?><?<@C@AC:>>>
@09T
AGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCT
+
CCBFFFFFHHHHHJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJHHHHHFFFFEFCEEEEEDDDDDD9@CDEDDDDDDDDDDDDDDDD
@09U
TTGTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCAC
+
BB@DFFFFHGGGHIGJJJJJJJHHHIIIIJJJJJJJIIJJJIJJJJJJJJHCHEDFFFFDEEEEEDDDDDDDDDDDDDDDBDD<BDDDDDDDDDDDDDDDD
@09V
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFFFFFHHHHGJJJJJJJJIJJIJJJJJIJJJJJJJJJIJJJJJJIJJJJJJJJJJJJJHIJJJHHHFFFFFFEEEEECDDBDDDDDDDDCDCDDDDDD
@09W
CCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTG
+
CC@FFFFFHHHHFIGGIJGGIIIGIJHIIIGGIIIIIIGIGHGIGIIGIJJJIJIJEB<;AB?@AAAC<CCDBDDD<BDDCCDCDCDCCDCDDCDDDCDCC
@09X
GTTTTCATTTCCTCCATCTGTGCCATGTGTTGTTTTATTAATTCTTGTTTCATTTGCACTATCTGGTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTG
+
;?@?BDDD<FFFDG@F9+<?IC:FDECCFFADC+:?CFDGEF>D>FDF@F?DFF>949?DF**0**/)...=)873=@.=4).7?3;?@?>;7=99:>8>>
@09Y
AAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATG
+
@@@DD?DFFFFDFGFGIID@FEFAHGEIGBGIGIGEHIEIGIDGGIIIIECDGGIIFHGGGIIIGAFGF>@CHGDEEEFD<<@CCEC;>AACCCC?C@CFC
@09Z
CTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGG
+
CCCFFFFFHHHHDIJJJJJIJJJIJJIJJJJJIIJJJJIJIJIJJIJJIHHHFFFFEDEDECDDDDCDDDDDDDDDDDDBDDBDDDDDDDECDDCCCDEDD
@0A0
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
@@@DDDD2C;<AF;C<GEFAFIHHCHIGE>BEGB??FH@3?B?F?BFDDGGD??DBDCCB3=@FG@AFGH@AHGEA??CEEBB88@CCCCCACACC>@CAC
@0A1
CACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTC
+
C@@DFDABDHFHHEHIGHGGIGHIGIIIIIGIGHE9DBDFCHIIDDDD3>CC@C@>C:@@CDDCDBCCCBBDDDDDDDDCCCDDCCDDDCCDDDCDDBDBB
@0A2
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
CCCFFFFFFHHHHIIIJJHHIJJJJ@FHJFGIJJIJFHJJIIJIIJIGJJJJHHHHFHFEFFFEEEEEEDDDDDCDDDDCDDDDDCCDDEDDDDDDDDDDB
@0A3
GTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCC
+
BBBFFFFFHHHHGJJJJJJJJJJJIJJIIJJJIJIJIJJDDDDDDDDCD@CDCDDEEDDDDCCCBBDBBBBBDDDDDDCDDDDDDDDDDDDCDD<>BCCDD
@0A4
CTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTC
+
8?@DDBDDH;CDHIIGIIIIGIIBEHHAFFBDHFIGECHDBDB:?CDDHHHG>FDDGIEHD<<DBCCHEF@@CFGE>DG@EC@DAEH>==A@@>@BA>;;@
@0A5
GTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJ?HHHIJJIIJJJJJJJJJJJJGHIIJJJJJHHD;@BDEDDDDDDCEDDDDDDDDDDDDDDD
@0A6
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTT
+
@@CFDEFFHHGHHGIIIJJIIJJJJJJJCGHGDHGJ8DFGIJJIIIJCHIIIIIGJJJGHHHFFFFFDDABBDDDDDDDDCACDDDDDDDDDDDDDDEDED
@0A7
CTCGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@@@DD7D@DF?<<A+A+<CFHFAF:1?DG@BBGEIIBF(B;68C(=D>AEECEEE@<B@@ACC;@@@A>AB@@5>;>@AABA:@>>ABAB@::A49A:?BB
@0A8
CGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGG
+
CCCFFFFFCCFHHGGIJJJJJJJJJJIJJJJIJJIGHIIJIJGIIIJJJJJGHHHFCDFFEEDDDDDDDDDDDDDDCDDBBDDDDBDDEEDDDDDDEDDDD
@0A9
GCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
@@@ABBDBHH8CBF@GAFHBFHGEBH?B8A;D9<EBABBAFCHDH@?A<4;6<BAAACCB95=?BB?BCC009-58CA::@CB?CC3>C:@D::>CC:@
@0AA
GCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTG
+
;<?DDDDDFDFFFIIE;FG>HF9?99A?CFG?GDD:BGFE@GF@?D<FDF@FFEFEFFA@==CEIII>EE>>EABB;@DD@CAA;@BD>>@BBBBBB8?B
@0AB
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
@@@DFFFFFFHHGJGGIGGCDHIGGHGIIIJJGHDEDGHGIIIGEGIGHHIGIJEGGIEGIJGIGIJJIGDDHE<5=;@>@C@C?BACCDDDCD9ACB:?B
@0AC
GGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGT
+
CC@FFFF?FDHHHICAH@GHH<CAFHIIIIIEAHI?DHIIDHEGIICHHIIIIIGIIIGGHEAHAEE>@EDFFFCEECCED?CCDDDBD5>?@@CCDCAD2
@0AD
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CC@FFFFAHHHHHJJJJJIJHHHIJJJIIJJJJJJEGGEIIJJIIJJGHIJJIJJJ=ABEGIEEHHD@?BEFEE;CCABD@CCDEEDDCDDDBDDDDDDDD
@0AE
CTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCT
+
CCCFFDDFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJFHIIIJGHIJJJJJIIIJ@EH=DHAEHHFFFFFFEEDEDCDCDDDDDDDDDDDDDDDDDB
@0AF
GGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAA
+
+;1A;=2=AD>?DFBG<EHDC<@16:CD8):BB0<@FAFBF>B9C).=CC)=@>CEE;=?737?7,;=5=5;@@A>>>55>:?:@>AAA(3+)5>8&4@B
@0AG
TTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCC
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJIJIJJJIJIIJJJJJJJJJGIIIIJJHIJJJJIJIJJJJJJJIJJJIJIIJJHHHHHFFFFFFFDEEEEEED
@0AH
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGT
+
CC@FFFFFHHHHGJJIIJJJJIJJJIJIJJJIGIIHJGGIIIJIJJJJJIJGGGIJIIFGFFEHDFDCDDDCCDCDDDDDACCCCCDCD@CCDDDCDCDD8
@0AI
GATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGT
+
@@??DADBFFFF>G1881:?EBFFGIIDI;DFF;BFCFIFFFFFFA@FEECECCC9ACEDDBBDCECCCB@A>;>>@AA@AABAABAB>8>9<BBBBBA@(
@0AJ
CGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCT
+
@<@DBDDDACDD?:<C?FFBHEHGED8?:?DDG999D>?8BBEF>C;;=CFAFDFE;CE1@EEEFEF;)7@?;6=@?@B?@<(::@5;:;>@BB:AB::A3
@0AK
GCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGG
+
@@@DDDABACDFFGDFEH;E>F?BCC9>DAGH@AD9?DFE6A@BEED?>B8<9@5@(>:33:A@>@@C50;@BBBBB5>@B<-09<0<9@CBB<>>9<<9
@0AL
CTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCT
+
CCCFFFBDCFHHHIIGHGHIIJIIJJIIJJJIGEGGIHIEFIHJJ?FHCIJGHII?BDDHGHGHGHG5;EGIJGHH.?CDFFCFCDD?@CCCDDFD?BDD
@0AM
GCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTAC
+
C@CFFDDFHHHHHIJIIJIJJIIFHIIHJJFHIIIJJJJJJIIJDHIIHGGHGGHHBEDEEEEDDDDDDDDDDCBDCCDDDBDDDDDDDDBDDDDEEDCCD
@0AN
GGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
??+ABDFDFFGFFIJJJJIDHIGFIIJ?BFF@GHGIGHGGGGEHIIDHGHIIIJGEGI@HGGEGACEHECHF>DDEFACDBDDDD(8;??B58A@AC:BCC
@0AO
CCGCTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCC
+
CCCFFFFFHHHHHJJJJJJIHIJJJJJJJJJJJJJJJJJJJHIIJJ=FFHJJJHHHFFFFFEEDEDDDDDDEDDDDDDDDEDDDDDDDDDDDDDDDDDDDD
@0AP
CTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTG
+
CCCFFFADHHGHHIIHHIDAFHHGIGHIIIFIIGGECGIEHHFFHHHFFFFFFFDDDDDDDDDDDDDDCCBDBCB@DDDDDDDD4?@BDDDBCDDDDDD:<
@0AQ
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJIJIJIIJJJJJGIJJJJJJIGGIHHHHHFFFFFFFDDD9?BDBDDCEDDDDDDDDDC
@0AR
CTCATTGATGTAGCTCAGGAGACCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCC
+
???DDDBDDFADFGIIGGC@GFHEEHGIDCCAH@9EF494:?BBF>GE9DHDACFC?FE3B>6=C@@H@474CCCE@C>BDE:@EAC>@;;?@??5@A89
@0AS
GCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTC
+
@<<BDFDFDHHHFIDHIJIGIIGFCEHHGIIIJIJGIJ1:DFFCEIGGHE?F9BGGGGDAG@CD=FGIHHGHIHIJGHDHFFC:CCBFFCCEEDDDCDDDD
@0AT
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
C@CFFFFFHHHHHJJIIJJJJJJJIJJIJJIJJJJJJJJDHIJIIJJ<FGHGGIJJJJCHHHHHHFFFFFDDDDEDDDDD?BBDDDDDDDDACDDDDDDD
@0AU
TTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCAC
+
@CCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJIJJJJJJJJIJJIJIJJJHBCEDDDDDDDDDDDDCCCDCDCCDD@BDDDDCDDD
@0AV
CTTGGCAGGGCCTTTGGCCATTGGCTCTGGGAATGAGAAGAACCCCATGAGGTAGAATTCTTCCCTGTGGCAGGTCAGCTGCTGATCCCACCACGTTA
+
@?@DDDDDFHHDHGGHGJIIIIIJGFGBFGIIIGDFGHIBDCGDHGB=CFHC=@=FEHIEEGIIIC??EEEBE<A>:ACC@CC5@,3:AAA=252+83
@0AW
CTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGT
+
?@@ADDDEDFFHDGHIIGFHHHIEGIIHIGGHCFDEFGGGIEHIDDFEHHACGIFG>?6;A<CFD<ABDEDCC@ED?;==?8??AC?CC:C>@C?@CCC>9
@0AX
CGGCATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
CCCFFFFFHHHGHJJJIJJJJJJIHIJJJIGIJIIIIHJJIJJJJJJJJJHIGIJJJIJIGHHHHFFBFFFFEEEEEDEDDCDDB:ACBCDCCDDDDD
@0AY
GTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGC
+
@?@ADBDDHDDFBGIGGD<AAEFHEEEHGHIHIGGGHHIIIIGGBDDGGCCHFCGC@FC@8=7=@DGGHIEAHHFEE>7?=BAABCCCBBCCCC:AC:C5:
@0AZ
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
<@@DFFFDDFFFDDBHHEDCEFHIIIGGGG?CCDFIGGICCHGC??DHFFGGGGGACHIGIIIIGGCGEEEH>;?;>@CEDBBDDCCCDD9@@BDCBB+
@0B0
CCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTG
+
CCCFFFFFHHHHHJJJJJJJJIIJJIIJJGIJJJIJJJFIIIIIIGIIJJJJJJI?FEHIIJJEIGIGIJHGHHFFFFFECDEFFDEDBCCDDDDDDEEDD
@0B1
TCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTT
+
CCCFFFFFHBFCFIJJJJJJJJJJJJIJIIJJJJIJJIJIGHJHIJJJJJIIIJJJJIJIJJJJJIHHIJJJIJIHHHHHHFDEDDEDEEEEEDDDDDDD
@0B2
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
C@CFFFFFHHHHHIJIJJIJIIJJJIGHIIJIJJJJJHJGHGGIJ@DHGIJBDDCEE@BBBDDDDDDDDBDBDBBCDEDDDDDA9ACCDDEDDDDDCC
@0B3
CCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCC
+
@@@DFFFFHHHGHJJIEEIIJIGIEHHIAGDHHICFEHHIGHIIIIJIEGGCGH7CFGFHIGHGGEAEEEEFFDC;@C@@DDDCCCCCCCDDCDDCCDDDD
@0B4
CCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTT
+
CCCFFFFFHHHHHJIIIJIIIJJJJHIGIJJIJJJJJJJJJJJJJJJGGIJIIJJJIIJJJJJJGJIJIJIJJGIGGIIIJJJHGHHGHFFFFFEEEEEE
@0B5
CCCAGGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGT
+
CCCFFFFFGHHHHJJJIJJJJJIJIJJJJJJJJJIJJIHGIHIIIJGIJIGGIJIJIJJJJJJIJJJHHHHHFFDDDCDDEDDDDDDBDDDCBDDDDDDD9
@0B6
CTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTC
+
CCCFFFFDHHHHHHIJJJJJJJJJJJJJJJJJJGIHIJIJJJJIJJHHIJJJJJJIJJJHIIJJJJJJJJJJJJJJJJHHGHHHFFFFFFFEFEEEEEEDD
@0B7
TTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGG
+
8;;DDDD?BF<DBG<FG?CAD<CDAEBHGHHB9C@CEEB??D@4B)BGB<?GGGGII4?<<<?<FDH:==8===7@C;@GICDEGCEEHBD;7(6(;@>;;
@0B8
TATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGT
+
CCCFFFFFHHGHHGJIIJGEGEIJGGHIGIIIJJJIIIIIGGHHIIIGHIGHJJIJGGGIGIIIGGEECEF>DCFF@BECCD<@A;>ACCDDDECCCDDD@
@0B9
CTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCT
+
CCCFFFFFHFFHHJJJJJJIGJIJJJJJJIGIIJJJJJJIJGIIFHIIJIDGGHHIJIIGJJJJJJE@FHIEFCBFFFFFCEEEEEEEDDDDDDCCCDDDD
@0BA
GCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTC
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJIJJIIIJJJJJJJJJJJJJJIIJJIJJJIIIIIGJJJJJIIJHHHHHFFFFEEEEEEDDEEDDDFEDDDDDDD
@0BB
GGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTA
+
@@@DFDFFGHFFABHIIGIGHIEEIGFHGGGHGGGIJGIGHBDBGGIIEIHIIGJGEGHICHIGDGHIAAEHH?>A>CCEDCC@5;@?CCCCDA>ACDCC
@0BC
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCT
+
CC@FFDFFGGHCFGDGICFHIIJJJIJIJJJIGIIJIJJJJJJIJJIGJIIJJJIGGICFEGGIIJJGHFDDDDDDDDCD>CCCCDDDDDDDDDDD<@B@B
@0BD
GGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGC
+
@@@DD?B?FF88CGHBGHGIGFG>@BACFHGHII?@FGIGI>CGIIIGHIIHIIIIIIEEA;ACHDEE>@C>C>BBB?ACCACCCA99<<CCDCCCCCCB
@0BE
GTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGG
+
CCCFFFFFHHHHHJJJCGHIJJJJJJJJJJJIJJJJJJJJJJJIJJHIJJJIJJJJJJIJIJJJJJJJJJJJJJHH=BEDCDECCDEEDDDEEDDDDCCDD
@0BF
CTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCT
+
CC@FFFFFHHHHHJIJJIJJJJJIIIIJJIIIBGIJJIIHIIGIJJJIHIGIIJFGHJJJIIJCIJGGCHGHHJJJIIEHGHFHHGHHFFFDBDDEEECEE
@0BG
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
8?@D7DD8ADFBFGEAEHEEIFHFBF;?CFA<C@*???D::B<D@?@FAA<BEC>@;A====?B/8<CAB9;;>8:CA>C@?9(3:>@:3>>@C>>+:
@0BH
CGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTG
+
CC@DFFFFFFHDFHGJGIIJIJGGGHJDHIIJGIIGAGHIIGGB0?FGFHHIIGHCGGGHGFFDBACCDBDDDDDDDACDDDDDDDDDD>CACCCA@CCCC
@0BI
CTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCT
+
@@CFFDEDHHHFHIJJIGGHIGIJJJEHHIGEGIHIJBFHHJIII@BFH?DDGCGHDGGGGIGIIGIGIIHDGIHIDFFHCCE@?>7@CEEEEEBCCDDDC
@0BJ
ATGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
@C@FFDDFHHDFGIGIIIIIJ<?CFGIJJIGEHIIJIJJGIJJGIIIGGHHDFGG@HFHBCFHF@FEHGIEHIHGHHGDFF?B>=;>CCCDDDCDDDDDD
@0BK
AGAGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGA
+
@C@FAFDDHFHHHEIIGGIIJIIGIIJJJIJIJIJIJJJJJIIIIAG7CFHGGIGHIFG=:EF3>?;ACDD:CBD?A?CDCDCACD8<@B?@0?CDDD@
@0BL
TGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCT
+
?@1B?=BDFAD?D@BFFBEFCFC9?B;9?:BFFE@BDGAFDFF?8.88=C9=@;@D>;CAAE=B;B;>@AB;6;5;;5;>AB@@A@@5<9::A>>ABB>@B
@0BM
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGAT
+
CCCFFFFFHHHHHIJIJJJJJJJHHIJJJJJIGIIJJJJJJIJJJJJJJIJJJJHHHFFFFFFDEEDEEDDDDDDDEEACCDDDDDDDDDDDCDDACDDDD
@0BN
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJIJJJJJJIIJHHHFFFFFEEEEEEDD3=B=CDDDCDDDDDDDDDDDDDCDD
@0BO
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTC
+
@@@DDDDDHFDFHIEE@E<BB;ABE;GC?2??@9?F@HC:?HFDDD8?A;5=FAHIE=@?;.58;=;;@6@B?C?C::>A:>>C:5<8(::@C@:4@:44:
@0BP
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CC@FFFFFHGHGGIGGICGG@CFHIJJJIJIGJIFCCFHIIIIIIJIJJJJJIIHGIJGIIGGEHIIJHGHFDD>BBDDDDCC@CCDCDDEDDCD@CCD
@0BQ
CTTCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
B@@DDDFFHGHFFEHIGHIIIJIJJJIIIGJJJJGHGIHGEHIIJJJJJJJGGIGGHGIEHHFEFF?ABBCDCDACBDBBDDDDDCDDDDCDDDDDBDDDD
@0BR
AGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTC
+
@C@DFFFFHHHFHJIIIJJIIIJJJJJIJJJJJJJJJJJJJJJJGIIIGIJHIJJJHFHHFECDDBDEEDEEECDDD=CCDCDCDCDDDDCDCDDDDCDBD
@0BS
GGGGTGGGTAACAAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
BBCFDFFFHHHHHJJHJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJHHHHHHFFFFFFEEEEEDDDDDBDDDDDDDDDDCDCDDEDDDD
@0BT
GTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTG
+
@C@DFFDDBD?FFEBGGAHIAEHBFCECCFEDFE@FHIIEDH:BBD?BFIGGCHHGGGHIIFGCHCG@>=EEEB5??=A@C@@??A?C@@>@AA8?B><?B
@0BU
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGT
+
CCCFFFEFHHHHHJJJJJJJJGIJJGIJJ:EHIJJJJJJIDGHJJIJJJJJJJIJJJJJJJJAHHFFFFFEEDACEDDDDDDDDDDDDDDFDEEEDDDDDD
@0BV
GCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCAT
+
@<@DFDDFDFHFFHEGIDGI@FGEHIGGHG@FEHIIF@@;BGIGEEHIGGHFBC:A>@@DDAABCDDDC<AC5@@?BDDD?CDD@>?CC@8>@ACCCBBCC
@0BW
GTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACTCAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCT
+
@@@FDFDDCFDHHJJJJJJGIHIGHJGGEHIJJIIJJJIGIJJJJGIIJIGJJJHIGDHIJJJGIJJIIIGIIJIIJIJIGHEHHFFFFFFFFEEEDEEDD
@0BX
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
B@@FFDFFHHHHHJJJJJHHIIHHGIJJJDGHJJJJJIJIJJJJJIIJIJJIIHHHHFGFFFFFEEEDEEDDDDDDDCDDDDDDCDCDCCDDB?@DBCDDD
@0BY
GCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCA
+
@@@FFFFFHFGBHIBFHIDEIIIII@HBHE@HHHIEGHAFIICHGIIDIIIIGGHHGIIIIIIIIIGGG(@CGDAHHHHFGHFFFFEECCCCDCCDDDCC
@0BZ
CCCTGGCTCCTTCCTGATAATGTTTAGTTTGTAGTAGTGGCGCAGGGCTCTGGACATTTTCTCATAGGTCATGTTTGTTCTGTTCTTATGGTTTCCCCAC
+
CCCFFFFFHHGHHJJJJJJJJJIJJGIHHIJFIIGIIGHIIIJJJIIJIJJIJJIJIJJJJIIJJJHHEEHHFFFFFFEEEEEEDDDDDDDDDDDDDDDD
@0C0
AGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGT
+
@@@DFFFFHGDHFGIJJJJIJIIJGIHGHJJJIIJJJJJJFFCDFEEECCC=@CAADEEEEDDEEECBBDBCDCDDDDDCCCCDCCCCCDDDDCDDDBBD
@0C1
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
C@CFFFFFHHHHHJJIJJJIJJIGIIJIIJJJJJJJJJIJIIJGDIJJJGIJJIJIJIJJJJJIGIJHHHHHFFFFFFFDDD9?BD=CDDEDDACDDBDDD
@0C2
CCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATG
+
CCCFFFFFHHHHHJJJJJJJJJHIJJJJJJJJJJJJJIIJJIIJFHJJJIJJJJJHHHHFDD@DDDDDDDDDDBB9CDEDDDEDDDDEDDDDDDDDDDED
@0C3
GTGGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTG
+
@@@FDDFFHHDDHAFEEHH<CFBEE?DHGHGIGIECGAHHDFDF<>;8?5>@CCCAC@C>@CCCDCCCCC>>>@CCCCC?<8?ACC>@CCC@CC?CB<8C
@0C4
CGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTG
+
@@?DBDDDHB4DA@:EFHGHC;<AAEBF@CAEAABGIFGII>F0?)B?DAGGCBFHGIIHIC>EGEEGEECHHFEEE)9AAC=@CCC>@CB5A?@CC@@C(
@0C5
TGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACC
+
@@CFFFFFHHHHHJJJJHIJJJJJIJJJJJIJJIJJJJJJJFIIIJIJJJJJGFHIBHGBHFFEHHEHFEFFDE;?C;CDDEEDDDDCDDDDCDDDDCDDD
@0C6
GCCCTCTCCTCTCCACACCCAAGGGTCCCGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCC
+
@@@FFFFFFHFHHJGEIIJDIECEHDEHIGGIDBGGCGEHIDGEHIIIEHGID>ADGGIFBEHBEFFAAE>>AA?ACCDDB>B<?CC@?B:>CDDCCACDD
@0C7
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATCCTTGAGTGGGCTGGGCG
+
C@@FFFDEHHDCDHGIIGHIIGJJGIJIBFHGIGGIIGJIEDGGGIGIGGIIJHHIIJIICHGHHDHIGHI7=A<CDEBCCCECEECD@CACBDDDDDDDD
@0C8
CGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACA
+
???DDD;:2:AD:2<A:E:FF:<F9FFD>??C9C?<?:?:D90:0B009DE<98B<B*9DDEI<885@AD;=)......7;??;>>;;A6>5>:>>;A>>
@0C9
CTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAAAAGGCTG
+
@@@FFFFFGHHHHIIGIDHIJIIIGHIFHIHGEICCGI@GHHIGIIHFEGGIIIIIGHEGGIIJJIIJJJJJJJJEECEHFFFDFFEFFDAEEEECD@CB
@0CA
AGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAAT
+
CCCFFFFFGHFHHJIGGG<AAAFGIHHCHIJJFEGEIGHIEGICHGGIFIIIJIFFGHHHFFFFFFFFECEDEDD:@D;AACDCDCDDDDDCCCDDDDCDC
@0CB
TGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGA
+
CCCFFFFFHHHHHJHIJJIJIHIJJJJJJJJJIJJJJJJJJGIJJJJJJJJJJJJJJJJJJJJIJIJII@GIJJIJHIJHHHHHHFFFFFFEEECEDDDD
@0CC
GTGCATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGC
+
@CCFFEFFDBHHHIIJGEGAHGGGIIIJFHIGGGGGEDDHHHGIJGGGIJIJIHEHFFFFFFFCCCCEDCBBBBDDBDDDDD>CC<CCDDDDDD5<?CDCD
@0CD
GTTGGAAGCCTGCGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGAAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGGGCT
+
??;B?;DBA?D<B:)2@1AE32?E9C):))5-;@6)).9?@(399=:9<<<8&583(3:A>AA30885;2>:((2<(288A394:A25<9028<(+:A?<9
@0CE
GGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTC
+
@@@DFFFFGGHHGHEGIJJIIJJJJJIJJHJIBHIJGGIJGJGIGIIIIJHHHJJJJJIJJJHGIIIJIHFHFFFEEDECCCCEDACDCDDDDDDDDCED
@0CF
CTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@@@DFDDA<BBFHIGIEGBHGHIGBAHHAHEDHGFGG@@DGFGGHIIICEG@BCDFEHE>@CA=@GIEGHFFBECABEFCBBC>>;AECC>8@?BBC5
@0CG
TTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTG
+
CCCFFFFFHGHGHIJIJEHIJJIIJIJJJJJIHIIJGIJJJJJJJGGJJJJJJGHHIJJJJJJJIIJJJIHHHFFDDDD>BDDDACBBDDDDCBCCDCDD
@0CH
CTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATAT
+
@CCFFEFFHGHHHJJJIAFGIHIFHGIJJJIJGGIIJIHGIJJJIJJJIJJFHHHBGBHIIJAFHGHJGGHF7?=?DFFDFDACBDCCDDDDDEECCEEDD
@0CI
GCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTAT
+
CCCFFFFFHHHHHHIIJJJJJJJIJIJJJJJJJJJHHJJFHIJJJJIJJIIJJFDD<BBDDDDDD;BDDDD5>BCEEDEDDDDDBDDDDD<BD<CDDDDDE
@0CJ
TCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTCAATTGTTCAGAA
+
CCCFFFFFHHHHHJIJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJIJJJJJIJIJIIJIJIIJJJIJJJJJJHHHHHHHFFFFFFD
@0CK
TCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTG
+
@@@FDDFFHHDFHIIJJIIGIEGGCGGEGGBHGFGHGGIGGGHIFACEHGDCFCCECA@BCCDDDDDDABCDDDD@C<AD8?B(8?>CDBDC?BDD48?0<
@0CL
CTACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
=@@DB:DD<HHBFFB@GBHFHIEBH9?EEB?688?:<F<D<27;CH@CCGIG=EH=?54;6>66;>@C->588=B<<CAC>CC?C:2>>@::@?BA?>C>4
@0CM
CATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTA
+
@=?=DBDAFA?F;<<@+:CFH<CGE<CFGFF4:CG<DDFGF>DFF>BD9DCAF=FFCDF4B<=FCFF:@EFICEEACEDB?DBCCCA3==;ABB:@>AD
@0CN
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGT
+
?=@DADEDDFDHGHIIGIG>FGGIHGFGHICDHIEGHBHGIGAFGFEHICCGEHCGBB@7<CCCC><49C:BCDAAA:A:>AB<B@BBBB@CCDCA>ACCA
@0CO
ACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCC
+
@@@AD<:DFAAFFBGHEFDDEHIIBFHEHI?FGEIIDBGHB3A>=E@DDEBCC9=?C>CDCCCCC@CCA@CC3@BB<?CCCDCCCCCBCCCCCACCCBBBB
@0CP
ATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJHHJJJJJJJJJJIJJJJJIIIJJJJIJJJIJIJJJJIJJJJJJJJJHIIJIIIJIJHHHHHHFFFFFF
@0CQ
TTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGGGCCATATGCAGACTGAGCTGCATAGGAGGCC
+
CCCFFD?DFH?HHCHHHGHHIIHHHIII@DGHHGGI@GHHIHGCBHGIIIEHIIIDC@DHEHHFHD>DB1=A@BCAC:ADCCBCCCCCCCCCCCCC@?>?B
@0CR
CTAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@CCF@EFFFFDDHEHIIGJGIGGCFCFGJJJIJJIJIIIHIDGIIGIJJJICIDEGEHIIIJHGIGEECHIJGHHHHHBDECC@ACDDCDDBADCDDCDDD
@0CS
GGGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGGCCCAGCTGGGTAAGGCGCCTGACTCTCTTGTAAAGGAGCAAGGGTTTGAGGCTTGGAC
+
?+++=++=+2CFFE@<;AFG<B4AF+9C1*1:C9***:DB)?BBF((08)-))).))'-5=;7));;;;3;66(-;5;;29(5((,,5(42<08()8>(
@0CT
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIIJIHGHHFFFDDEEDDDDDCCCDDDDDDDDDDCDDDCDDCDDDDDDDCDDD
@0CU
CTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAA
+
@@@DDEDDFDAABGHIGHIGEHBHGHAFEHHCHGGG@GFGFGGDHBCFG3BDDHIIGE@DHGIAC>@CGHHI@EIHEHEB;@DDCCEEACE>>CCCDD@;
@0CV
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
;?<D;D8DACBD:CGFEBB>E;C9CHHEE?FF0?FF@@;8BFFI@>;FFIC2617AED;7;?@AA@>ABA35?B35>AABA>A;:54(>ABB@AABDB::A
@0CW
GCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTG
+
@<<DBBDDBFFBFFE?@D<CBGCEGEFGI@?8CCDEDDCBGGF>BFF@D>FF=BFEEFFFEIC@C@=;CEEDDDDD6;;@@BB@@5(-,;=:=2>??<4<
@0CX
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
::?=A31:CADA:3AAEB3CE+2CE>>DEICD*C>D>BDD>BD3?BDD4B/0*==BC=BC;78---:4ADDA;;AA6;>;A;>>A>-9A>,:>(5:A>AA>
@0CY
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
CCCFFFFFHHHHHJJHIJJJJJIJJIJJJJJJJIJJIIJJJJBHIJIJIJJJJCHIJJHHFFFFEEEEDDDDDDDDDDDDCDDBDCDDDDCCDEDDDDDDD
@0CZ
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
BBCBDFDFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHFHHFFFFFEDACEDDDDDDDDDEDDDD5>DDBCDDE
@0D0
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@@@D?DDDB??C?C?BFH><CBCA@CE??BFDDB@F6B;F=8CCBGECA=>CD@EA==@D>;;>>A;@CC:((5;@C@@AC:@@((,5?8:?B94?8>C:
@0D1
CCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGAC
+
???B1+A;C=DDBE4E<EE<BE<3:CECD<;ECCE?B@3*:1:?B<0:9<<99BD:<D:?DDDEDB=BCC@C;;A@@A@@CDDDD>ADD@D:@A>@A@3A;
@0D2
AGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCT
+
?@@FFFFFFHHHGJIJJIJJJIIJJJJJIJHIJJJJJJIIIGGIJIIJGIJJJJIIJIJJJJCGIJHHGFFFFFDEC>@CDDEDDDDDDDD>ACCDDCCCD
@0D3
GTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGC
+
CCCFFFFDHHHHHJJJIJJIIJJJJIJEGH?FHIGIIJJIHGGIJIJJIJIIIJGIJIEHHHGDFDD1>CDCDDCCDD=BBBCDDDDDDCCDDDB?BDBB
@0D4
CTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTA
+
@@CFFFFFHGFHHIJJJJIJJJJIJJIGJIIJJJJJJJJJJJGIJJJJIIJJHJJGHIHIJHFHIIIJIGGIIIGIIIJIHHHHFFFFFEEEEEEEECDD
@0D5
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
CC@FFFDDHHHHCFHIJJIJJJJJJIJEGIDGGJJJJJJJJJJJJJJJJJJJJJJJJJJGGIJHHHFFFFDEEEEEDDDDDDDDDBDDDDDCC@CC@DDE
@0D6
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
CCCFFFFFHHHHHJHHJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJHFFDEEEDDDDDDCDDDDDCCDCCDDDDDDDDDD<CDEEDDD
@0D7
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCT
+
@<@;DDD8?:A?FEGGII9CG9F;;CFFFEB<FFFEDAAFDD?F?DFC9FB)=C:;;A5=45>AA(.;?>?BBBB@3>A3:AABBBB><98<::>A@AAA:
@0D8
ATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCT
+
CCCFFFFFHHHHHEIJJHIJJJJJJJJJJJHJJJJJIJJJGJJHIGIJJJIHIJJJJEHJJJJJHHHHFFFFFFEEEDDBDDDDDCDCCDDDDACDDBDDC
@0D9
CGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGC
+
CCCFFFFFHHGHHJJIJJJJJJJHIIJJJJHIIJJIJJHIJJJJGHHFFFFEDEEEEEDDBDDDDDDDDDDDDDDDDDCDDDDCCDDDDBDDDDDDDDDDD
@0DA
GTCCGTAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGT
+
@@@DFDFFHHHGDGJIJIJIIIGJJJIJEIIJIGGIFFHIIEDHGCGHIJJJJIGHIAEFHHHFDFFFEDEECEEBDD;ACDDCCCCCCCDDACCCCCD>>
@0DB
GGTCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
@C@DFFFFHGDHHJIJJIIGIIEEGHGEGECGHGGIEGIGGGIJJAHIIJJIIJIJJIGGHCHHFFFFCECACEDDD@BB?CDDDDDDDDDDDDDDCCDDC
@0DC
TATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATAGGTCCTTTCAGTT
+
C@@FFFFFFGHHFGGIIGHGHGIJJJIIIIIGEIGI@FHGIJJIIIJJJIIJ:;CHGIIGGIE?AHEEDEFFFECCEEED>>CD?CCDDDCCDDDDDC@BD
@0DD
CCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGC
+
C@@FFFFFGHHHGJFHGFHGHGIJJ>HFHAC;C>?DGEECHHCGGHFG;BGHAAAB4@EGGFGHHEFFFF;ACC>AAC>A=?BD=?>(;ACCCCDDDDC@:
@0DE
CCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTC
+
CC@FFFFFHGFHFGGGGIJJJIIJFGGFGIEH?FHGGIGIIJJIIIEFACDDDCCCDDCCDCDCDDCDCCDDDB@B9<9>@BDDDCDABDDDDCCCCBDDB
@0DF
CTCAGACATCTGGCGTTGGTACATAGGGCGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGT
+
CCCFFFFDFHHHDGGFGHEGGHEIHHCGGGIJGIGGGIIIJGHIGJGIIIIHHFDCC>ABDDDDDAB?CCDDDDDCDDDCCCCCDDDCDDDDDDDDDDDDA
@0DG
ACCCATGCTACTGGGGTGGGCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTT
+
@@@DDDDAFFBFAA;CE8C)?FFC:C6DB@?GFICFIFFFEIIIF@@E;CEFEC=A;@D;;?>;ACCADABE@AAB@:>@9?BBBABBBBABB3?@AA3>>
@0DH
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTG
+
@@<DDDBDHDFDH<FE@B3AADBFHIA@?F?EB<DHDAHIEDBDDGGGEEBHIHIGGE@GCEHCGAACCEBHE<A?;C@?@CAC@CC@CCCCADC:5@A@A
@0DI
CTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTC
+
@@CDFFFF?FDFHHIIIIIGHIIIJJJGIJGDEGFGHIJJJIJI<GGHGHIGGEHHHEHGE;BEEFD<BBD?CCCDDDDCCB>BDDACCDDDCCDDDCBB?
@0DJ
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIHJJJJIJJIIJIJJJJJAHFDDEEEEDDDDDDDDDDDDDDCDDDDDDDDDDDDD
@0DK
GTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTACTTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCT
+
@@@D?DD;DDBDFBFBAF@FFA?@+AAFFGFED6?BGEAA75;@FE>@EFFDF@(;;@D;@A>;.;?@BB9:5>((:-9>5>595<29@(819@9<>8?@1
@0DL
CAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTGCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCGGACAAAGGTCAGGGGGATTGGAACA
+
1??=AA?DADA,,A@AE:<?,AE4:CAADEF>*?3CDD)***?19BB3*B*9'<@7==CDEIC:@=C)7==C37',''355>3(5,9(255599<1(4(8
@0DM
GGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCT
+
@<;B?DADDHHHDAECFEGDG;FCDGGIB@FG9B>@FEGFHGHIAFHA6@4@C;DGHEFEECB1=BCCCC@CC>?5=?>@6=B&99>B84+:43444>>>A
@0DN
CACTCAATGACCTCCGTGTTTGAGAGTTGGAACCATGGCTGCTTTCCATAGGTGAAGATCTCCCAGAGGATCACCCCGAAGCTCCATACATCACTCTCTGT
+
@@CFDFFFGFHFDGHECFEGCDBGGECEHGCEHIIIIGGIIGDHGIIIDGF@?==FH=CCCHIIIIIGCEHCC?DDEDD>9=C>CC>ACCAACCCA@CC@@
@0DO
CCACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATGGTCACAACTCCATCTAATAAAG
+
CCCFFFDFFGHGHA@FHGIHIIIIIIIIFGHIIGHIIGEGIIIEHGIIIIAGHCHGEHICHCHGIIICGHGHCDEFGHHCEFFFDCECCECCCCECCCC
@0DP
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTC
+
CC@FFFFFHHHHHIJJIIJJIIIIJGIIIIIGIIIJCIGIIBDGIIGIGGJIJHHIJJIIEHGFFFFFCCEEDD@@BDDEECEDCCDCCCD@CCDDDCDED
@0DQ
CCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCG
+
CCCFFFFFHGGHHJIJJIJJJJIJJJJJJJJJJHIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJJIJHEHHHHHFFF
@0DR
CTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGT
+
@@@FFFFBHHHGHGIICFHICIHD@DABFAFFHGIHIIGGHHGHIGGEGGDB;@@=;CEEHE@CCD@CC@CCA;ACCCDAACC>@CDCCCCC?BDCDDB>0
@0DS
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
CCCFFFDDHHHHHJEHHI>GGGGGIHEIFIGIIJJGIJJJIIDFHIIIGFHFGHAFHEGCAHFGEG@C@G7?EF,;?C>CCD;?B(<CCDACDDDDDBDDB
@0DT
GCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACC
+
CCCFFFFFHHGHHJJJJJJJJIGIJIHHJJJJJJJGIJJJJGHHJJGHIIJJIJJJGHJJJJGIIIJIJJIIGHDDBCEEDEDA?BBBD@>9?CCC?CCD
@0DU
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
CCCFFFFFHFBHHICFHGGHDGGHEHIAEF?DF?FHGGICHIEDHHGGCBFHGGIIIIEF>>CCCAAC;@@CCDDC@C@C@CA?@4>AC??@C::A@@CC
@0DV
CAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGGTACACTGCAGGTGGGTGGTCAGCTGCAACATGGCCTGGCAGCCTGGCC
+
BC@FFFFFHHGHGIJIJJJJJJJJJIJIIIIIJIJIJIJIIIGGHJJIJIFGHDCDEDEDCCDD;@@B=BD9CDDDCDDDDABACDDDCDDDDDDDCDBDD
@0DW
GATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJIJJJJJJJJJHIJJJJJJIIJJGIJJJJJJHHHGHHFFFFFFEEEEDEDDDDE
@0DX
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGAC
+
CCCFFFFFHHHFHHGIIJIIJIJIIJJIIIIIGGIJJJJJGEGIEHIJIIGGHIJ@CFCHIJIIGIIHHFHHFFCDFECCEECDD@DDBBD5;B9?B9@>@
@0DY
TGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJHHHFFFFFFEEEEEEDD;?DDFEDDDDDDDDDDDDDDDD
@0DZ
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGG
+
@@@DFDDDHFHHHJIIIIGHGGGIIIJEIIGHIJGHIJGIJCHIBHIJJIJJFGIGFIIIIIIJJHHFHFEDDFDFFFEEEEEDEEDCDDDDCCDDDABDB
@0E0
GCTTCCAGTTGTGCCCGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCT
+
CCCFFFFFHHHHHJJJJIJIIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJGIIJIJJJJJJJJGJIJHHHFFFFFFFEEEEEEECDDEDDDDDDDDDD
@0E1
GTGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCT
+
CCCFFFFFHHHHGJJJJIJJJJJJJJJJJJJJJJIJGIIJJJJJJJIJJJIJJJJJJFHHFFFDEEEDDDDDBDDCDDDDDDDCDDD?@BDEDDDDDDDDD
@0E2
CTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCTCTCCTCTC
+
CCCFFFDFHHHGFGHIJJHIIIHIIJIGIIIIJIJJJJIJJIJGIIJJIGJIGIJGHHHHHHHFFFFFFEEECCBCCDDDDDDDDDD>BDDDDBDDDDDDD
@0E3
CTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGC
+
?@@1D;DBFHHFHIIBBFGEHFBCCDHIBBFGFBGDGGCHIG;@GGBGE<?F<?BGFH<48@CF@@GD:@EHHCA=;?B7?>:;;@@==5>@?BBB>5(4
@0E4
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCAT
+
CC@FFFFFHHGHHJJJJIJJJJJJJIJJIJJJJJJJIJJIJJGIIJJIJIJJIJJJJJJHHHHFFFFFDDDDDDEFDEDDDDDDDDDCDDDCDDEDEDDDC
@0E5
CTCCATCTCAAAAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCAC
+
?@+B:A:?DDF<<ED?AE;FGFE?GFECFIIE@:??8CF@F;;FEIIFE6A<>2=35:AABBBB(>AB34(4>4+4:>@A+22?::@44>A:>@>A8+(+9
@0E6
GCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCT
+
;@@DD?A=??<?<C<AAECCIHHEE:<FE@F?EF:??D9CDGBG>GGHI>F9??FCBFH@=CFHGDEH=C;7=A?EE;7?DDBD@6>3;;;?;>;;;5,:@
@0E7
TGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACC
+
CCCFFFFFHHHHGJJJJHHGJJJJJJJJJJJJJJJIJIJJJJJGGIIJIJJJJCGIHHI;CHHHHHHFFFF@DEABC;ACDEEDDDDDDDDDCDDDDDDDD
@0E8
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@@CBBDDFGDFHGIIIIFCE@FHACGH*CDFGFGE?EHHG@FHIGGHFGHICH@EGGCGGGEEGEEFFFFEE>A65>>C>@A>@;@CAC@:A@:?ACCC@A
@0E9
ACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTG
+
CCCFFFDFHHHHGJJFHIJJJJJJJJIJJJDHHHHHGFFFFFDDDDDDDDDDDDDDDDDDDCDDDDDBBDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDAD
@0EA
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCTTTAACCTTATTTCTCTTTTCACTTGGGGGTCATCTGTCT
+
1?;D+B;2CD8CCAEEEBFFI<A?FB?C?F+C1??)0:D@?B*6@0DDI99B8.=BBCCD3).=@=;@@@ACCDCD=@DDA7))666>='',88A(:(++:
@0EB
ACCATAAAACGTTGCCATCCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAA
+
CCCFFFFFHHHHHJIJJIJJJIJJIIIIIIIIJIJJJJBFHHIJJJFHIIIGJJJJJHHHGHFFFFFFFECEEEEDCDDFDDDD?BDCDEEDCDDDDDDD
@0EC
GACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJGIJJJIJGIJJJIJIJJJJHHHHHHEFFFFFEEFEEEEE
@0ED
CATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGG
+
CCCFFFFFHHHHHFHIHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJIGHHHHHFFFFFFEEEDEEEDDDDDDDDDDDDDDDDDDDDDDDDEDDD
@0EE
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFGDHHGIIJIJBHIIIIIIJIHJJJCCCGHIGJH@FGGDDFHIHIIJGGEEHIJIJJIJDHHIHHEFF6>>CEDEBDBCCCDCDD<CDDCCBD2
@0EF
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@@DFFFFHGFHHJJJJGIJJJJHIIIJIJJJJJJJJJJJJJJJJIJJJFIJJJIIGIJJJIIJJEGHGHGHFFFDFEFDDD>BDD;CDDEDD@CDDDDDD
@0EG
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCT
+
@@@DDFDDHHHFGHIIEGGGEIIGHIIIBBGF@?FDBDFFDGEB?FBGEGHGEGCGGGCH>AEEFFEDEEEDEDBD,8;=CAC@CC@>5?@DACCA@CCDC
@0EH
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGG
+
CCCFFFFFHHHHHIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJIJJDDDDDDDDDDDCDDDDDEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDD
@0EI
CTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCG
+
CCCFFFFFHHHHHJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIIJJJJJJJIIJJIJIIIJJJJJJJHHHGHHHFFFFFFEEECD@
@0EJ
TAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGA
+
CCCFFFFFHHHFHIJJJJIJJJJJJJJIHHIJJIJJJJJJGIHIJJJIIJI@GHIJIHDHGGJJIIJIJGGHJIHIIJIIHHHHFHFFFFFFFDEEE@BD
@0EK
GTTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
;;@DDADDH<B<DFDGHIGIGHCHIAFHFAA?;CDBFHGDDH@DHBGBEGGIBCG=CFGIGGEG>AE9<BC@>;@C>CACACCCB<BBCACB<BBCACBB
@0EL
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@@@DDEDDHAFB?BGHHIE@HEBHGHIA?GGBHGGGIIIII9BF?DDHCDHIIIEIHIGGGI>C=AB8?EBD?;7(;>>>C>@;ACCCCC@:>=:<CB<(:
@0EM
CGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTT
+
@@@DDDDB<ADH?EFHIIIII?CGHEE:E9C<DGCHIIG@BFFGICHBHGE@GE<@=@CCFEAE@AAC;D>=AHE.=CEC;B>ACBBBCAC?@BBBCCDDD
@0EN
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
???B1?:+2?CDDAEEIBFD9AAFCE3?+22C:EEDDDE<BDDDC899?B*/9?=4BC33;A535(7)753;?(.66>5;A;(-59<<?A::=?70)24(:
@0EO
CTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCC
+
@CCFDFFFHHHHHIJJJJJJJJJJJJJHJJJJJIJJJJJJJIJJJJJJJJJJJJJJHHHHHHFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0EP
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
?=?DDFFFADAFDBHDIBHDEHHGE2CFHFD>H:BBFDFGGGIIG=BG>DHHIGIGHIIBEFCEE=535;;>ABCCB55@CCCBBBB<?:ACCCDADDCCC
@0EQ
CGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGT
+
@@@FFFDFGHHHHGIJJHJIIJJJJIJJIJJJGIIIJJIIGEGHHHBGGGGIJHHHHHFFFFECBCEEDDDDDDDDDDDDDDDDDDE>CDCDDDDDDDD0
@0ER
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJ?FHFGIGIGHIIJJJIJIJIJJGIJJJHHEFFFDEEEEDDDDDDDDDDDDDDDEFEDDDDDDDDDDDDDDDD
@0ES
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAAC
+
CC@DF?DDHDF@FGGHGBHIGJIHIIHGC?DGGIGIJHJIJJIIHHIIJEGGHIJGIIJJIIGGHHFFFFEEEDCCDDDDDDDB>BCDDDDDDDDBBCDED
@0ET
CTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGG
+
@CCFDFFFHGDHFJJJJJJJJIJJIJJJJJJJIIJJJIJIIJJJJJJIGIJJJFHHFFFFFFECDBDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0EU
GAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGC
+
@@CDFFFFHHHHHJJIIJJJJJJJJJJJJJJJJJJJJJJJJJIJIIJJHIJJIJJJJHHHHHHFFF@DECEEEEDDDDDDD?CDEEDDDDDDDDDDEDDDD
@0EV
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
@CCFFFFFHHHHGJEFHGGG@HGHIGIHFHGIJHHJIIIJJJIIJJGCEIIIIGGFDBCACCDEDCCD>CC@@BD@DDDDCDDD>A@CCD@>ABDCDDDDC
@0EW
TGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@<@DDDBDH?FFDG>>DBEHGGFHFHIIIIIGAEAG>FGCBFHA9BCGI@G;BF@HHG=EGGEE@EEDEEC?@C>@>?3@ACA;?BBBBBBC@CCCC@@CC
@0EX
CAGCTTGCAGCCCTCTCTCAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGAAAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGT
+
<<?DDDD:B?+<CF;A;EGDHDF?GDF<3C?BBCBBF;FGF>;B38?71(.(====C;=....(;;B@9(;@>@B;@BB<?9>B??<@?72>989?8<??+
@0EY
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJJJHGHHHJJJJJIIJJHHIJJJJIJJJJIIJJJJJJJJIHHGIEGIJHHHEHHFFFFFFFEE>CED@CDD5>@DCDDDDDD8AC
@0EZ
CTTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
@C@DFFDDFHHFHIGGEHIIIIEHFHIII?CDHGIIIDGIIDC?FFHGIGEGHGHIHEHBBDDEECCEDCCCCDCCDADDCDDBCCCDDDD@CC@>?BCDD
@0F0
GTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTG
+
@@@DDD?A:<DDDFGBDEEAIH<CBEFID?=F<6G@8DFE<FE:DF=DBFFFE)=FFGI=FFADEEF>A?EFFFC;B=BBC@CBBBB:BBBBBB@B,&5@>
@0F1
GCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCG
+
B@@FFFFFHHHHHJJIJIIEHIGEGHHHIGGGIJJIJJIHIGHIJHIGGHIIHIIJEHHHGEHFF?BEEDDDBCBBDD?B?CCACDDACDCCCDCACCCCB
@0F2
AAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAACAAGAAACACAAAGAAAGTTAGAACAACTCCGGGC
+
@@@FDFFFDHHFFIAGHICHGHI@HIIIIIGGIIGFHIIIIIIGGEIEEHG4DABGHGIIIGHIIHGIAEHHAEBDFD>CBECCCA@AACDDDDDDDDBD
@0F3
CTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGG
+
@@@FDFFFFHFAFGGGJIIIBCFE?DCEEHHGIIGIBDG?DEHEHGD@FHGGGGGIIGGDEHCEHGHBBDD@AABCB?BDDDBDCDEDDDCDD
@0F4
CTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATAC
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJ=FHFHJEHHHHHHFFFFFCEEABD?CDDEEDDDDDDDDDDDDDDDDD
@0F5
TTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIJJJJIJJJJJJJJIJJJJIJJJJJJGHIJJGHHHHHHHHFFFFFFEEEEEEEFED
@0F6
CTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTG
+
CCCFFFFFHHHHHJIJJJJJJJIJFHIJJJJJIJJJJJIJJJJJJJJJJCGHJJJIJJJJJJJHHHHHHFFFFFFDDDEEDEDBDDDCDDDDDDCDDDDD
@0F7
GGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGG
+
CCCFFFFFHHHHHJJJJJJIIIIJJIIJJJJJJJIHIIJJIJJJJJJJIJJIIIIJIJJJJJJIHIJJIIIJJHHHHGEFFFFDCDDDDDEDDDEDDDDDD
@0F8
CTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTG
+
CCCFFFFFHGHHHJJJJJIIJJJJJJJJJJJJJJIJJIIJIJIJJJJJGIGIJJJJJJJJJJJJJGJIJJIJJHHHHHHHFFFFFFFEEEEEEDDDDDEDB
@0F9
GCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTGTTCTGCTGGGGCT
+
B@CFFFDDHHHGBGHIIJI@HEFHGHGHIJGHEGGIIIJGGHHJJGGHHJJ3=CHGG@DGGEGGE=CEEEEFDFFFFE@CEEEDDDDBDC@DA>C@ABDBB
@0FA
CCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCT
+
@@@DDDDD:42<AA@FGFE@A<FAACBG<?CB>D<FDAFFFFF(?7(BFEFF>F7@.@EECAA;;BD:?/<:8?BB@A?B8559&)5<@BAB@@BB75><9
@0FB
GACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFDDDEDDDDDEDEEDDDDDDDDDDDDDDDDDDDDDDD
@0FC
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
CCCFFFFFGHHGDHGJJJJJGIJJJJIJJJIJIJJJIJJJJGGIJIIJDGHIJHIJJCFHIJIJJIHHHGFFFFDDEEDDDDDCDDCDDDBACDDDDCDDB
@0FD
CTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAA
+
CCCFFFFFHGHHHGJJJJJJJIJIIJJJJJJJIJJJJHIGGGIIIIIIJGIJJJIIHIJIGDGGIJJJJGJHHHHHFFFFFFEEEEEEDDDDDDDDDCD
@0FE
AAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGC
+
@@CFFFFFHHGHHJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJHHIIJJJJJJJJJIJIJJIHHHHDDFFDDDDDDDDACDDDDDDCDBDDDD
@0FF
ATCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGG
+
@@CDDFFDHDHHDGGGIJJIFGGHIEGBGGGFHGIJDIHHIIJFIJIGG@DHHGGBBECECEEDC@@@>@CCCCDDCDCCCC>BBDDDDDDCCCCDDB5<B
@0FG
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
@@CFFFFFFFHFHHGIIJJIJEHHIH<FHGDCEHDGII?FHIBGHD/8BGGIIJIGH5@CHHAECDFFBDEDDAEDDDDBBBDDCDBDDD:AACDDBDDB5
@0FH
ACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGAT
+
@@CFFFDFFDDFHIGGHIGDDHIGAHHHDHIEIJJHIGIHIGGCHIJJHIIHIGIII@GHEGIGHE?AHFC?DF@AA?;@CBC@?CCCDDAAA@C>@BBB>
@0FI
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
CCCFFFFFHHHHHIJJJJHIJJJIJJJJJHHIJIJJJJJJJJJJJIJJIJJJJJJJJJHHHHFHFFFEEEEDEDDDDD;@D<CDDDCDDDDDDDDDDDDDD
@0FJ
CGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCC
+
B@BDDFFFHHHHHJIIIJJJJJJJJIGIJJJIJIIJIIJIJHGIIJJJIJJJJIIIIJJGHHIJHIGIJJJJJIIFGHFHGFFFEFFDEDEDDDDDDDDD
@0FK
TTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGG
+
@CCFFFFFDDFFFEHGIIIIIIJJJIJJGIJIJJJJIIJIJHHHHHFDDFEE;ABDBCBDCCEEACDDDDDDCDDBBD8CCDDDDDDCDCDCCCDDDDDDD
@0FL
GGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTG
+
CCCDFFFFHHGFHJJIIIIJJJJCHGIIIGGIJGIJIJIGHHIJIJIIJIGGIIGIJJJJGJIIGIJDEEHFFFEDEEEEDDD;@CDDDDDDDDDDDC>AA
@0FM
CAACTTTTTCTTTTAGCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGT
+
@CCFFDFFHFFHHICHEHBIIGEGIGIIEIGHGGIIIJJIIIIECGDDHIJIJHIGIJEECHJGGAHAEGCIJJHHEACEFEFFFFEEEEEEDDCCDC@
@0FN
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@CCFDFDFHHHHGIGIIIFHIIGIGIIIIIJJIIJIIGGJGDDFHJDHHIIFIJJGEGGGHJHGHHCEFFDFEDECDDDDDDDDDDBBCCCDCDDDDC
@0FO
TTTGTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGCAAAAACG
+
?@@ABDDDD?DBBGGGHB@DDGHEAEHIHEHHCEHI=GCCFEEEHGCGHIGHGEEHD@<BGGGGHGGA=C=@F>G@DECCAEHBCBCCCC;???BBBC@B3
@0FP
CTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJHGIIJJJJJJJJJJJJJIJJJJJJJJJIHHHHHFFFFF;AEEEEDDDDDDDDDD?CDDCDDD>
@0FQ
TGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCAT
+
@@@DDADDFHDFBGEG3EFHIIGBEH9FH@F9EEGIG@GGIIEGGCGF<FGE;FG?D?*?FH:FBCH@GC;CG@DADCEEEEHACCDEBECCCA@CCCCCC
@0FR
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
C@CFFFFFGHHGHIGIJJJJJJJJJJJIIIGGIJIJIJIJJJIJJIGIJIJEIGJJJHIJIJIJIJHHAEHFEEEFECEEECDDD3=BDBDDDEDDCCDD
@0FS
GCAGCGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGT
+
CC@FFFFFHHGHHJIJJIJFFHIIJIJJIJJJIGDHIJJJDHJIJJJIJHHIJIJJIIIIJJJJIIHHHHGFFFFFFDDCCDDDDCCCDEEDDDEEDDDDC
@0FT
CTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGT
+
@C@FFFFFHFHFDHHHHIJJJEGJIGJIBHHGIIIIEFHGGJGIJJJHIJIIJAGGGIIIIGEGGGHGIGCHIGIIAGIJHGHHHFFDECCAECEEDEEC>
@0FU
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTG
+
@BCFDEFFHHHGHEGIIHIIJIIJCGFHIJJIJJJJJJJJJJIIIJJJJJJJJHHHGHHFFFFFEEEEEEDDDDDDDFDDDDDDCCBDDDDDDDDDDDDDD
@0FV
GCTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCT
+
8??DDB8=D@FABB:CGICHEFDDDDB=GDDBDGFIED@FE@CC=CFF@C@=A=EDDB?>A?;????BB9?B59<?BB38+82@>:@@B??A<>B9<><@>
@0FW
TGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAAT
+
;?@DABDBFDDF+AACG9DCEC3+AC@AE4?@GFGFBGFG@GFEFFCGIB@?3?9;?:?*8BCE<@4)=F=CECA@E:?=7)77?3;)7;;;36;;AAA>;
@0FX
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGT
+
CCCFFFDFHHHHHJG@FHEGGHJJIEHGIIGIIJIIGEHHIJIIIJJJIIJIHGI9@FFHGIIIIIJJI@GHEHEHACDEFDDCBDBB9<BCECCCCDDC
@0FY
CTTGTGTTTTCATAGTCTGTAGTTCTAACTGGTGTATTTTCTGAAGTTCCTTGATCTTTTCCTCTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAA
+
CCCFFFEFHHHHHJJIJJJIJJIJJJJJJJJJHHGIIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIIGIJHHHHHGFFFFFFEEE
@0FZ
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
@@CFDDDDHHHHHJI<CFGIGGGFIIIIGIGIJIGIGIHGIIGGIGIIJJJCHGHIJGH=FGGIGIJEECHHHFDC?C>>>C>CCDA>CACBCCCDDCCCA
@0G0
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@C<DD@DDDDDDDHGGGGEIIGIGHIIIICDGIIGI@HHIIIGIIIGHGIGGHIGBF@EHGIH>E6CEF=EHFDBBDFDDDD38@B;AA@DDC:@BB?BBD
@0G1
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTG
+
CCCFFFFFHHHHHJJIJIJGIJJJJJJJJJJJHHIJIIGHJJHIIIJJJJJJJJIIJJJJJJIJIHHHHFFFFFFEEECBD@BDDDCDDDCDDDDDCDDDD
@0G2
CCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTGAGCCCACTTGAGCCACTGG
+
:;?ADDD?H=DFHIIIBGHGGEGHIGICHIGIIG<FEG@FHEBBFFHHGGAFBGGC<CFHGIAFCFHGIIIIHC@EEBDEEED?ACCAB@CC>3@>CCAAB
@0G3
CTTCCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTC
+
@BCFFFFFHHHHHJJJJJJJJJIJJJIGIIHGIJJJJIIFHHIGGIIJIIJJIIIJJJIGIJJJJIIJJJIJJJIHIIJJIGIJAHHFHCHEFD;@EFDD
@0G4
GGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTG
+
??@D?BDFGHFHDHIJGGIJGIJJJGHHIIGIIIJJIIIGIHGHJJIIJIJHIIJJJF7@EFEHFFDFF>@ADDDDDDDDDCCBBDDDCCCDDDDDCDDD
@0G5
CTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTT
+
CCCFFFFFGHHHHJJJJJCGIIJJIIJJJJIJJJJJIIJGHIHHIJJJJJJIJIJIJJIJJJJHHHHFFFFDEEDDDDDDDDDDDEEDDDDDDDDDCDDDD
@0G6
GGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTC
+
<<@DDDDDFHHFFIHGDH+<EHD??FEEDGHIIIIIIIII;B7FDEHIIBE@GGCFHGIIIIIHAEHFEBCBDCCDACCCCCCCCCCCCBCCACCACCCDD
@0G7
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGT
+
CCCFFFFFHHHHHJIJJJIJJJJJJHHGJJJJJJJJJIJIJIJIJJJJJJJJJJI9@FFGHJHIJJJIJJJHHHHHFFFFEECDDBDD<>BCEDDDDDDD
@0G8
CTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJEIJJJJJIJHHHHFFFFFFEEEDEEDDEEEEDDEEDDDEDDDDDDDDDDDC
@0G9
CTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGT
+
CCCFFDFFHHHDFIHHEGIHIGICHCHGIHGIIIGGGIGHIGIGIGIDFGHCHIIHFDDB@=ACCDCDEDDBDDDDDDBCCDD@CDDDDDDDDCCDDDDCA
@0GA
GCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGCAACTGCTCTGATCATAACTAGTC
+
@CCFFFFFHHHHHJJJJJJIIJJJIJJJJJJJJIJJJJJJIJJJJIJJJIJIJJIJJEIJJIEGHIIJJGHHHHFFFFFEEECEEDDDDEDEDDDDDDDCC
@0GB
CTCGGTTTTCCAGGCATTTCACATATCCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGG
+
C@CFFBDDHDHHHJIDGGIIEGCCF9FHIG>GGDAHIJIHGBEGEGIII>DGCBEGF@AGI:D:@737=AA;7;;;>CCC@>@C>@3@CD@;A@5@CCBD@
@0GC
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
C@CFFFFFHGHHGJIIJJJIJIJIJJIJJJJJJJJIIJIFIJIGIJGJ?FHIIIGGGIIG@GGGGGGHHEHFFFFEFDDDDDDD;=B?BB0<CCDDCDCD
@0GD
GTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGAGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCC
+
=@@?A;2=4CD<:2<CAA@GEFFDFF*?E<FCGF@<90:0?D*9)*06@FAFCFA':;CFCB1);;;>;ACBAA@A>/8==@8:>3:>((4@&5<08A@A<
@0GE
TCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTC
+
?=?DBDD??ADBA<AAAE?33ABF:F<EDCEEEFF>?EDFDIDDFDFI@?DDC@BDEDEIDEBBDBCEBC<@=AEEE@CDIIE>=????CCCDDDEEEA@;
@0GF
GGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATT
+
@@@DDDFBHHHDBBHEDFHFFHBCHEHGGHIEIEGI@FHDHD;@DCG===ACE?BBB;CCBBB=>>@C>C8CA:>>CC:@>CC>BDC@CBBCB<@BBB3?>
@0GG
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
1??;ADD?;22<DA:@AE:<:3C?F?8:C@60:09D99/07(<C=;8@DII@4@7A=5-=1?A((;6(;(>555>9555>;A;A5>>;>>(+98>>8(>2<
@0GH
CTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTT
+
@BCFDDFFHHHHHJFHIGIJJIJJJIJJIIJIIGJJJIIJDHGHJIIIIEHJGEIIIJIJJJIJGGGIIIHEFFFDDCBDDCCCDDCCCCDCC?CCDDDDE
@0GI
GATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCC
+
@@@FFFFFDHFHHFHIIIJJJJJIIJJJIJ?DGEIGIIJJJBGHIIJIJJJJJJJIHGHIGIJJHGHHGHHFFFDFFEACEEEDDDDDDDDDDDDEDDDDD
@0GJ
GTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTG
+
C@@FFFDDHDDBDGGGDHGIHGHJGEHGIHGIJJIJFGIGHIJIIIGGEDFCDCGHHGGCHIIIIEHDGIHHEFFFFD?B@>CCCCCC>CCACDDDC@DCC
@0GK
TTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTG
+
C@CFFFFFHHHHHJGIJJJFEHGHIJJJJIJIIEGIJIGGGIIGEHGGGGIIIIHHEHEHGFFFF@CBCCCEDDDDDDBBCCCDDCDCCB@BB@DCCDDDD
@0GL
CTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGG
+
CCCFFFFFHHFHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHHHFFFFFDEEEEDDDDDDDDDDDDDDDDDDDDBDDDDDDDEEDDDDDDEDD
@0GM
GCTTGACGTTTTTCTCTTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCC
+
CC@FFDDFCFFFHIIJJIJJJIJIJGIGIJGGGJJJIIEIGGEHHGHIJFHHHFFFDDDDDDDDDACDDCACBDDDDDCD?B<@BDCCC?ACDDDDDDBBD
@0GN
GTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCA
+
@??DFDEDFHHDDHHABGCFB>EHHEHIGGDHIIGGEBGIEHBCEGHGGEHGDHCDHDHD@FGGIEGIHCHEHGHGAH>CHFH?CBCBACECCCCDB=BB
@0GO
TGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGT
+
?@;DDEDEDFFFFHIIIIIIADFFGFGGHIIIIIIGHCHIIIGEEGGIHGFGFIGEH@FIICHIAGGIIIGCGGHCEHA7=>=A>AAC@DDDDCDDDDDC>
@0GP
GCCTGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CCCFFFFEHHHHGJGIIJJJJJJDGGGHIIJEHIJJJIGIEIIDGIIGFFCAHEHBHHGHGIJJ5AEFBDC>AACEDDDDDBDDDDDDDDDDDDDCDDDDD
@0GQ
CTTCCTTCTGCCCGTGACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTT
+
CCCFFFFFHHHHHJJIJJJJJHIJJIIJJJJJJJJJJJJJJJJJJJJJIJJGIHCHFFDEDEECDDDDDBBDDDDDDDBDDDDDDDDDDDDDDDDDDDDDD
@0GR
GCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACC
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJIJIJJJJJJJJJJJIJJJJJJJIJJJJJJJJJIHGHHFFFFEEEEEEEDDDDDDDDDDDDDDDDDDDD
@0GS
GTGGCTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGC
+
@?@FFDFFDFHHGIJIFGGIIIFFBCEEHEGHIIIIGGHDGGBHGIEHIGIIIIGHIGII@EHG=D=ACH>CDCCEEFFFDEE:A;?BC?C;?CDCCDDD>
@0GT
CCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCC
+
?88BD@;D?=D<A3CABGGA>@<<BH:BGGIIBGEA49?DGD=FDDF9*9*?8BGCC<F>@)=FAEHFFECB9&)<:@><88<??<(8+:9(8?>CCCCC3
@0GU
GCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJHJJJJJJJJJJJJJJHIIFHIGHIJJJJJIJJJJIIJJJJHFDEEDECEDDDDDDDDDDDDDDDDDDDDDB
@0GV
TGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGT
+
BCCFDDFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIJHGHHFFDDEEDDDDDDCCDDDEDDDDDDDD@
@0GW
CTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTG
+
;;??BDAB>FDDBGEH9C<C<3CEDGHI;?<EF@<?F<1?:?BDDHG@@F:'-;@GH?A?3?;?@??;(633@>>?;AA;C<?B,:>AC=A@AC>CCCCEA
@0GX
CTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGC
+
CCCFFFFEHHHHHIJIJHGIJJIJJJJIIJJJJIIIGIJGGIJJJJJJJIEABEHHHEFDDDBDDDDDDDDDDDDDB@BBCDDDBDDBDDDDDDDCCDDDC
@0GY
GTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTT
+
@@@DDDBDHHHFDAEFHIHIHICFGHGHJIJGBHIIIGIJGGIJGIGIGGHIIGIIGHGHIGIIIIEHFGED@?CDDFFEECE@>AA=;=CCCDACDBBBD
@0GZ
GGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGT
+
?<=BB:?A<323CEFF8F>=EE@C:?*:BFC>EGGDFADFBE4'-=;.=?7?B,;3;@ABB@BBA@BB@@?:<3:>BAAB:(4:>+:>?8585?@>@2?B9
@0H0
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATC
+
CCCFFFFFHHHHHIFGHJHIJJAGHIIJJJJJJDGIJJDHIJJJJJJJJJJJJJJHHIJHHHHHFF@CFEEEEDDDDDDDDDDFDEEEDDDDDDDDDEDDD
@0H1
CTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCC
+
CCCFFFFFHHHHHJJJJJIJJJHHIJJJJJJJJJJJJJJJJJJJJJJJJJJIIJIJGIJIGHHHFFFFFACEEEECDEDECDDDDDDDDDDDDDDDDDDDD
@0H2
CTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGG
+
CCCFFFFFHHHFHIJIIJJJIJJJJJJJIIJJJBGHIIJJJIJIJIIJIJJEHFFF?DECDD?@?CDDCDACD@CCDDDDCCCACCCDDDDDDCDACDDD
@0H3
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
@@@DDDDDHAAFHIIIIBFEEDFHCCGEAEFHDCHGEH@FEDGGGEEHGIEHCHIIIEDGBHDFBCCEEDC>;@C@?@BBCCCCACCCCCCCBABB>BBB
@0H4
CCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCC
+
;@@;=BDDAFDFFE@FFEFFEBHEH?FHHCHHIFIFEGFF<?BF>F@FDE>FFB@?BB>D@<BCE48@@@FCFEEECD4??A3??E7;?DDD>BCC:A;;>
@0H5
GCCCCATAGGTGTTCTGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
?@?D=BBDDD22CE<F>AFA>FFFEE>F222?EC@>FF??9D0?FBFFBFEEFF:9BB?DFEEEF>AAA;A6A=?.)7?(;>>>AACB;@AB;?@B(:??
@0H6
CGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
?@@DD>ADF?DCDF:BE2CEHBCCEGHI<CEG>7GDGHIEIGHGII@?D9>CFFBG7AH459;>AAAACAC;A59>C@CAA5:<CA:?C2?89:>AC>>>
@0H7
CTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATT
+
@CCFFFFFHHHGHJJIIJJIJI@FHIJJJJIIJGIJIGIJJJIJIJJHIIJJJIHFFDDCEDDDACDDEDDDACBBDDDDEDEDCDD@BBDDD>BDDCDDD
@0H8
CAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTAT
+
BCCFFFFFHHHHHJJJJJJIJIJJJJJJJJJJJJIJJJJJJJJGIIJJIIJJJJIJJJJJBFHIJIJJJIJHHHHFFFFFDDDEDDDEEFEEDDDDDDDDD
@0H9
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATC
+
CCCFFFFFGHHHHGIJJJJIJF@EGDHIJJDHHIJJIIJJJJJFIJJIIJIIIGHHHFFFFEEDEEEEEDDCDDEEEEDDDDDD:ACDDDDCCDACDDCDD
@0HA
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTT
+
C@@FF;DDHFHBHIIHGGIIIIFHIIIHIJJEFGGGGJIJFGGEGEHCBA>BACEDCEBB@CDD:>BBBDBCCCADDCCDDDDBDCB@BDDDDCCCDCDCD
@0HB
TACAATCTTATCTTTCTGAGAGGATCTGGCCTCTGCACTCAAGCAGTACAAAACAGACAGGAAAACATCTTCATTCAGAAACACTCAGCCAGTCAGGAATC
+
;1:A?D>DDAD4?CEEBCFE<E1+3<<C2<<+1:?*:CDEA99D?B??>BD<@?@89;8=B9AA;@;A@A;77=7?A7??;@AD3>;A@@=5;A>A?A?(:
@0HC
GTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGC
+
@@@DBDFFGHFFD@;8EEA@DGHIEIIEE?DDDEGGGHGAHGHGGGGFGGCEGGEGCEGGHGHHH3@D?CCFEEEED>@>@CDCCA>:>>CCCDDB?<@
@0HD
CCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJHIJJIJJJIJJJJIJJJJJJJJJIJJJJJIJJIJJJJGIJIJJIJJJIJJHHHFFFFFFFEEEEE
@0HE
CTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTG
+
CC@FDFFFHHHG>EHHIGBHIII@FHIIEI=:BDCCCCB@;BBBBBBCCCBBCB3@CDDECDEDCCACCCCCBBBCCCCCCCCCCBB<9?BCCCCCCCC+9
@0HF
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
CCCFFFFFHHHHHJHHJIJJJJIIJIJJJJJIJJJJJJJJIJJJJJJJJJJIJJIIIIHGIJH:BDDDCDDDCBDDDDDDDDCDDDDDDDDDBDDDDDDDC
@0HG
CTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGAACTTGCAGCAGAAATACTATCAT
+
?@@7:=BDB?DDBFEFEEF4A@HBDEFHB@DH>E?EC@F)C?DD?BDDE<3?99;DCFBF6AF9DC:7==CE;?;??)7?ABCCA;@2;=;5:A:A:@>5>
@0HH
GTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJIJJJJJJJIJJJJJJIIIJIJIIIJJJJJJGIJJIJIIJJJJJIIJJGIGIJJIJHHHHFFFFFFEEEED
@0HI
GTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACT
+
CCCFFFFF??ACBFHGIGIJJGIEEHBBFHGGID:@DB?BFAGGIIHGGEHGHGHB>;>BDD@?@>;>CACCB?19<?>C:29955ACCCCD<@?AC?<AC
@0HJ
CCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATT
+
<?@FDDDBHD?ADGBEEDE@HHGCDHE@HHEHEHIGEHCDHGGG>9B?DGCFHHIEBGA=F=FCEGHIFHH>AB;?B;?CCAEEEECB@@CCC:=B@?CC
@0HK
TGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
1?@DBB=1<CFB?CAF9:+<+<:C?HFHII>C<6869<?BDF88BB@@9CF=C3DF@=CF:);B?DC;@>6(;ABBBB:A:;@:959??>:AB@A4+:AB
@0HL
CATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAG
+
@@@DDDFFHDHFFIJJJIGIJGIGGHIIJGIIIGEIIGIGIGGFGIGIGGGIIIGIIGIIIIJJHHGFDBEDBCEECDDDDDCDDCCAACCC
@0HM
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@@BDFFFFHHHHEIEIHJFIGIIIGGDFDHFGHI@GGIIJCHIJJIEGEIJJIIIHHEEDDCEE>CEC@CCDDDDDDCCCDDEACDDDDDDC?CCD9C<?
@0HN
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
@@@?DDDFFDDHCEFAGIIIDBDA@HHEEBFFDGFFBCHGGAFF<DFGGIIGEB8=CFEECD@E=@AHGFH'9<?BCACD@@>@??AB<@AB8@CCBBCC
@0HO
GTAACAACCAGAAATATTCCAACTATAATAGTAAGTATGAAACTTGTTTCTGGTATCCAAAAATCATCTTTCGGTGGAGCGTCAGTGGGCTTTTGCTCCA
+
@;?DADDDDDF?FGE@GIB>HH9;FBEFEHECCFHCGEGGHHGCDHIII<@DDBB<DHGIGIICCAD@BCAAGGIG>EAE><?<<55;21=ACC:>>ACA
@0HP
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
C@@FFFFFGGFHFIIJJJJJIIJJIJJJEHGIIIJJJIJJJJJIIGIFIIJGIJJJJJJHHFHEEB@ACEEEEDDDD8=:5ACDDC>@BDDDDDCCDDDCD
@0HQ
CTTGTCTGAGTATTTCAATTTCTTTTTGAATTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTTAGCTTT
+
=?:+ADDD>?F>>FEEE>?:?<CHF9@CA>+AB<4CE?D<EFFEF<D3:*:BB@FE<*???<4*9?D=<CC>FEEE==737.)7.==).7)73?B@7@>AA
@0HR
GTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCC
+
C@@FFBBEHHGHDHGGCEHEBFHEHHII>HHHBGHGIGJIIIIJJGHGJGIGHIEDHHIHHJJIGIJDHGEGGIIJJJIJHIJJIIEGHEHEEHF>CEFFB
@0HS
AGCCGTAGTCGGTGTACTCGTAGGTTCAGTACCATTGGTGGCCAATTGATTTGATGGTAAGGGAGGGATCGTTGACCTCGTCTGTTATGTAAAGGATGCGT
+
CCCFFDADDHHHFHHGIJDHFGHIIJJIIGIGGIIJCG9BGGGGGHJGDHIGHEHJICGHIFIDEHDEEDDEDDBDDCDDDBDBDCCDDDEEEDDBCDDB<
@0HT
CGCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCG
+
?<?A7?=2222<<:<C:A4?<AAFB<<9:CEADE8?:C?:?)0?8?D>?D*8//=BB=;;C@C7@@C;7777==CA);;A@AAAAA>A>55>5>55:5>5<
@0HU
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJJJIJJJJJJHIHJIIIJHJJJJJJJJFHHJGHJJ<EGIFIIJIJJCCHHHEFFFFFFDEDDDDDDDD?BDDDDDDDDDCCDDDDDDD
@0HV
GTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCT
+
@?@DDDDDDHFDH@FGDEBBEFHAFF@?;FF<HBFHI2@=@EH?EEHH@B>ABB??CBCC::@@AAC:>AC>@CCC::3@CC>:ACCCDDEDC(::C8A@A
@0HW
GGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCC
+
BCBFFFFFHHHHHJIJIJIJJJIJJJJJJJJHHGIIJJJJJJFHIJJJJJJJJJJJJJIJJIJHHHHHHHFFFFFFFEEDEEEDDDDBDDDACDDDEDDDD
@0HX
TGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
B@BFDEAEHHFGFGHBFHEGIGHJIIIIIIIJJJJGJJIIJGIGIJJIJGDGIIJIIJJIJIJGJJJIGHHHFDD@BBDDDD@C:?CD>CDCCDCBACCD
@0HY
CAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGT
+
CCCFFFFFHGHFHJJJJJIIJJJIIJJJJJJJJJJJIJJJJJJJJJHHHHHHFFFDEEDDADDDDDDDDECDEDDDDDDDDDCCDDDD?BDDDDDDDDDDD
@0HZ
GTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTG
+
@CCFFFFFGHHGHGGJIIIJJJJJJIGIGHIIJIJJJJIIIJJJIIIJIJJJJHHHHFFFFFEFEECDDDDDBBDDCCDDDEEDEDDDDBDDDBBDDBDD
@0I0
CTTGCTCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTTTTTCTGGGGACAGCAGATCTGCCAGAAATTGAGGGTGAATAGATCGGAAGAGCAACTCC
+
CCCFFFFFFHHHHJJFGIIHIIIIJJJJDGEGFDHGIIGGIJJJJJJIBEIGEIIJJICHHGHIIDHHHHHFHCEDE5?BCDDDCCCBB@@BBBCDDDCCC
@0I1
CATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTT
+
?@?DDBDDA?<CFB?:EGDH<FHHFCCH@H<CFHCE?E1:CC:DFG??B;?FFFH@EGICGGE=F2.==@AGECEFECD);;@AC@CB@?=?>ACC@>@5>
@0I2
CTCCTCTTCCAAGGCCATGAGTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTTCTTCTTGCTCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTT
+
@@@FFFFFHGHHGGGIGIIGGCBGGGIGIGIHHIGBHIJGGGGEGGIHIEHBBGHGFHIJIJ>CHIHGCC;EDCEFFECEEEECDDB?=8?CB>AC>ACDC
@0I3
CTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGTGGCTCCAGTC
+
@CCDFFFFHHHGHGHJJJDHGIHJJJIJIJIJJFGIIIJIGGJGIJJJJJJIIHGGGGIIGIGIIIIJFFHHHGFFFDDCEDCEDCDDCDDDDDBDDDDDD
@0I4
TCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTC
+
@@@FFFFDF>??DGGIEHEHHDGHHGDCHGGA@D?D3CCD>D9??DE@BBGBB3/?D?BGE=BGGHIIHIGIGHGCEHGFHEE@E3);?B?ACECC3>(;;
@0I5
GGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGG
+
@@BDFFFFHHHHHJGHIJJIIJJJJIIIJJJJJJGHGHIGGIIIIDGEHHIIJIGJIIIG8CGGFGIH?CDFDFFCCED;?CDD>AACDDDDDDDDDCDDD
@0I6
CTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTT
+
CCCFFFFFHHHHHJJJJJJGJJJJJJIJJIJHIJJJJJJIJJJJJJJIJJJJJGHIHIGIIIGIJJJJJJJHFFHGGHFFFFEFFEEEEDEDDEFDEDD?B
@0I7
TGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGA
+
@CCFFFDFDDDHFIIJIIIIHJGEHIGIEGIIGGJIDGGGFEDGGGI?DHIIJIIHJIBFFFHIJIG=CEHIGEEFHEDEDEADDB@BDBBDDDCDCDDC
@0I8
GTTTCTAGGGGACTGGTTATGATCAGGAAAGGGAATAATAGATGCACAGACACCAAGGATCATTGAGGGATGAATCTCACAGTGTGTATATGTGGAACAAT
+
??;D;:2A?3C:<:AFA:CFHFCH<A<+1?GF8F@8094BD9?9*0?*B;2B9788@5@F@;7CEEFCE/;;BDBBB;>>CC(--5,5>--5;>A3>5??B
@0I9
GTTGCCTTGACCACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGT
+
@?@ABDDDHHHHGHIEGIHEHIGIJJGGAGEB?DDHHIEG?<GHHGHCHGGHIGHIIBBGIJIIGGEEDFF@>@AACBDDDD?@@CCCCCCCDD:4:@C>
@0IA
GGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATG
+
??;BDDDDFHHAFG=GH9CGBEHHII8ACHCFID@GDF:BF?FHGFHHGGA<FHIGCGCCH==(@@GEEE?=EE>B<9<8;?85<9?CCCCB9CC:@C<>@
@0IB
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@@DBDBDFFFFDFFCB2<A<ACFFDFEBHBFFFI:??GFIFCGIE?DGFFIEDEFFEFEF@DCEIEEEEFDB@BBBBBAA>B:?B>BB:@>@@B:@BB
@0IC
TCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGC
+
CCCFFFFFHHHHHJJJJJJJIIJJJJJJJJJJJJJJIJJJJJJIIIJJJJJJJJJJJIIJJJJJJHHHHHFFFFDDEDDDDCDDEDDDDEDFDEDDDDDDD
@0ID
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@@FBDFFHHHHHJJJFHGHHJGHJJJJJJJJJJJIIHJIIJIJIJJJJJJIJJJIJGIGGJJDGHIHHGHHFFDDDDBC@CDCDDDDCDDEEDCCB@CCD
@0IE
CTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAA
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIIIJIHJJIJIJJIJJGIIJIGIJJGIIJJIJIIIJJHHHHHFFFFFFEEEEEED
@0IF
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJFHIIJJJJJIIJJJ4EHIJJJJJJIJHHHHHFFDFEEEEEDDDDEDDDDDDDDDDDCDDDCDDD
@0IG
AATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTC
+
CCCFFFFFHHHHHJJJIJJJIJGHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJIJJGHIJJJJJJJHFFDDDBCDDDEDDDCDDDDDDDDDDDDEED
@0IH
ATATATTCAACAGATGACCCATAATATTTTTACATTCTGAGCTTTCCACAAGAAATCACTTTCAATAAAACCCAAATTTAAAAAATACAAAATGAGGGCCT
+
@@@DDDDDFCFDHIG@<F<3AGGAEHHIICGIE<?BCG9??9DHGHGHBHIIGIIIGIIIIHIIGHDGBGEHGHHIEFHHFFHECBCACCCB>CC3:82<8
@0II
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
BCCFFDFFHHHFGIIJIIIJJIJJJIJGHIIJJIJJJGJJIHIJJGIJFGFIHGGGGJJJIGIIJ@DEIHHGD?DCDEEEDCDD;?CDDCDDDDDDDDDD
@0IJ
GTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTG
+
<@<BDDDD><DH+CEFHGFHCIIEGIGAEAH>FE?CBGHHICFFEGGEF?:?DD>BFD<DGGDD<?@F@<<..=@;/@C;3)7=ACE?EDCE:>;>CCD>
@0IK
CTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTC
+
@@CDABDDDHHBHEBFFIGDEHEFHBHEFHFFEBHGGHBCDDD?BBDDHIGGIIICBGGB<FHIIC88@8=@AGE@CEHAA?C?@CDFCDDCE@DC@;CB:
@0IL
GTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
@@@DFFDDHGGGGIJIJGIJJJJDFHIIJJGIJJ?DGGIJJIGGIIIGJJJIJJIJJIEHIFII>GEGIHHGHHHFFFCDEDBCD@BCCCDDDDDBACCC
@0IM
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
B?BFFFFFHHHHHJJJGIJIIJIJAFGIGEHIIJJHHIJIFGGIJIJJJIIJJJJJJ8@EHGHHFFFF?CECEEEDDDDDDDDDCFDEDEDDDDDDDDDE
@0IN
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCT
+
@@@DD;D:DFB::CFFAFD<B@@>EG*1C<B:<*:??DC9499866;F;FD48C37@E'-',6>A;(5(3388>@A:((55:>:>@1<5@0<AB94@>@(:
@0IO
CTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATACAGTTT
+
@@@DDADB<CDDC?+<<ED?:3C1FG>B;?F00?;????9899(.75@5(..7C;;.7==;;;=;@(;@A>66(5>A;A3?9>:8>555(+(+++4>444:
@0IP
CCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGG
+
CCCFFFFFHHHHHJJJJHFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD<BDDDCBDBDDDDDD5>BDEECCDD?BDDECD@CDDDDDD
@0IQ
GGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCC
+
C@CFFFDDDHGFGGHIIIJJIIJJJJJJIJJJJICFHJIJJJHIIIIIIIIGIIJIGGGHIGGJGIIJHFFDDCCADDDDBDD?BDDDBCCDDDDDCCCCD
@0IR
GGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGT
+
BCBFFFFFHGGHHJJJFHIJJIIJJIIIJJJFHIJIIJ?FGIJJJJJJJIJIJFHHFFCCECEEDDD@BDDFEADDDD;AACDDDCDDDDDDEDDDDDDDC
@0IS
TGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
@@@DD??DHAFH?CBCHE<<FACHE@EEHICHG?FGIDGF>FHGE=CCCFH)77CHC?==7A??BE6;A>;@>CC?C;ACC;>C@<?@?>>>@AC>ACCC
@0IT
CCCAAAGGCTCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCTTGCCAGCAAAGCAGTAGT
+
@CCFFFFFHHHHHJJJIJJJJJJJJJJGHIJGIJJBFHIJIIJJJJIHIIHFDDDDDDDDDDDDCCDDDDCDDDABDBBD?CDDDDDDDDDDCDDDDCCDC
@0IU
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
CCCFFFFFHHGHFIIJJJIGIJIJJIJJJJGIHIIJIJJJJIIJJIIJJIJJIIIJJJIGGAEHHHDFFFEEDCECDDDCCCECECCDDD@CDDDDDDDDD
@0IV
GGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCT
+
?@@DDDD?F;<<<AA?:2<<<AHFD9A881::000BFH?8/?B8855@6.57=76=C;C;>?;6>>>;555(5>;:ACCCCA>:555:4>4@::A(44433
@0IW
CACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCG
+
CCCFFFFFHHHHHJIJJJJIJJJJJJJIIHFFFFFEEEEEFDEDDDDDDDBDCDDDDDDDDCDDDDDDDDDCDDDDDDDDDBDCDDDCDDDDDDDDDDDDB
@0IX
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
@BCFDDFFHHHHHIJHGGIJJIIJJJIIIJJIJJJJJJJJJJIJJJJJJJJJJJJJJHHHGHHFFFFFFFEEEEEDDDDDDDDDDDDDCD@CDDDEDDDD
@0IY
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
BC@DFDFFDHFHHIGIGGIGHIIIGJFGH<DGGGHIJJJIIJCEGIGJAEGEHFBFH@FHIIGECGF?C>CEFDACD@EDBDDDDCDCBD@CDDACDDBDD
@0IZ
TGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJIHFDDDDDDDDDDDDDDCD>CD@CACCDDEDDDEDDDDDDDDDDDDDDDDDDDDDD
@0J0
GGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCC
+
@@BDFDDDFHHHGJJJIJEGHHIIHHIGCHHIIIGIHIJJJJJJJJJIJJJJJJIJJIGIJJJIGGJJJIIJJJIJ?EHHGFHFEFFFFEDDEEEE
@0J1
AGTCATTGTTGCAGAATATCACCGAGGTATGTTTTGTGTGCTCCTGTACACTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTT
+
CCBFFFFFHHHGHJJJJJJJJJJJJJJFHGJJJJJJIJIJJJJJJJIJIJJJJHJJJJJJJJJJJJJJIJJJHHGHHHHFFFFFFEDDDDDDDDDDEDDD
@0J2
CTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAAT
+
@@CDDFFFHGFFBFGHHGIHFHECHIJGIHIIGBBFHHCFHIJBFFGCGHIGGHJBEGIGGGGBFEIBGHGICCGCGIJGEIGEGEEFEHHFEFFFCCCED
@0J3
CGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATG
+
@@@DDDDDF?DFF4CFDGGI?CFHFHFIF<CCGEFGIDDDBFCADEFEFE@@DDFE?FEFDEGAFGG>CEEEFFD)=7?E:AD==;>>?CC?>AB@BDBBA
@0J4
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
@CCFFFFFHFHHHJJIJJJJJJJJJHHHIIJJJHGIIIJJJJ:@GI@FHIJIJFHJFIHHFFFFEEEEDDDDDDDDDDDDDDD@CDDDDDDDDEDDDDDDD
@0J5
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
@CCFFFFFHHHGHJJJBHIJIIIJJJJIJJJIIJJJJID@GHIIIJGGIJJJIEHHGFFHFFFFFFCC>BDDDDDDDDDDDCDDDDDDDDDCEECDDDCC
@0J6
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGAGGGCTGTCC
+
???=BDD??FDADE;A@;A:32AFAHHG9@B:9D>:BFHII@0-<07C@FAGGA>CE=2?7?;@3;).(.;A;=BB5->>,(;>>3>5:(((+8.<8.(4>
@0J7
GCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGG
+
@;?DDD<@F?FFBAG<:A<<?<CH<FA@FEFII?BFGFIAAFBBAGI<FFE6@@FF@@@E?77=BB;>9?(3,5-5(5:A99'3+4+:?@@@B>><B(:A<
@0J8
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHHHHHJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJHHHHHFFF=@DBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0J9
CTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTG
+
;??DDDDDDBDFHIBHBAHHGGEHACDC@H<0??FBB*9BFBGEDFHGH8CGGCE@CHCEDHCH=ACHEBBD@CCA=?@>A@C=??B??@9<3A>A>::A
@0JA
TTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATG
+
@?<D=B>>FDH?HC@FB?C,<EAHHGHBA@<C>DC><:C?9?DA<<@<4?B<<BB:9?D@<@FD><@@<CEGCCHE>A@@4@A=;>)7.7=;>>C>>3?);
@0JB
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATC
+
C@CFFEFFGHGHHI:CFHGGIIFGGHHEGIIJEDFEGHBGEHGCEHGIGIIICAHGGIJGHGGHDF7@BCECED??BCDDCD@DCDEEDDCCCDDDDDADD
@0JC
AACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGTAATGC
+
@@@DDDDDFF?<C3CFFFF@BGCEEFGCFGEDGFIIECFF@BFEBCB8@DFCDAEEIDFEDD>@B@CCB???8&099@BBBB<@2<3<>->>BB8@B@:>
@0JD
CAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCT
+
CC@FFFFFHHHHHJHIJJJJJJJIJJJIIJHGJIJJJHHIIJJJJIIJJIJJIJEHIEGIIIFHIIJIJGGIIJJHHHHHHFFFFFFDDEDEDDDDEEDDD
@0JE
CTCAGTTACACACTTCTCAACTTGGAAGCTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTC
+
??;7DADBD>83CE9::+<?A4<AFF+++<AFE3*11:<?*11?B<?9DD<B<999;DD@CEEEEI>;5AD;@D:C;CC3777;.6.(;;((53(;>9=5>
@0JF
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
??@?+0ADFAAC3ACFBE<EGF@GFFFFF?DF@9B=>BB9BAF@<=@<F@4C;A;)7@=CC>E@=4'393>>::5@?=9?BA<3:(::>4>BABB9<98?+
@0JG
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
@??=DDDD<DBH?ACFACCE<EHH>31?CF?FAHGEGIIEIGECA???<@FD96@@F@>=D>BHEBBB2;BCCAC@@>@CB;ADDCCCCCC@CDDECCACA
@0JH
GCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCT
+
B@@DFFFFHHHGHJIIJJJJJJJJDHEHJJJJJJJJJJJJJJ?DFFGGIIIJIJIGIIIJJHGGIFHGCHFGGFD;BBDEDDDDDDDDDDDDDDDDDCBBD
@0JI
CCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
@CCFFDFFHGHDFIHHHIJIJIJIJJJIIJJIGJIJJDHIIJIIJJJJJJJJJJIJIIJJJJJJJJJBHHHFFFFDEDDEDDDDDDDDDDDDDDDDDDC
@0JJ
TTCACATTAGATGCTGTCACAAATGGAGGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTCGAATTGAGGGCAGTCTGAGTAAGGATAA
+
;?@D??DAD>DFF@::CFF<<:A<:FEEE;AFAE;EGGBD?;FF3?BFEF@BFFIIIA(8@4@'4=8??;;>=?BBBBBBB85<>??ABA>44:@BBBBA
@0JK
CAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTC
+
=?@DBDADFHDHHDBBD??I>BH?CF@HB?FGC2?CG@@?FB@<1?DHGIG@BDHCEFHGEGDBF>F>=AC@HGBD>CEE;E7;?BEE>@A>C@AAC78@8
@0JL
CCCTGCTCATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACAT
+
@CCFFFFFHHGFHJJJHHIJJJIJJJJJICIJIIJIJGGIHIIIIGIJJFIGHHIIJIGJIJEJJJGGIIFGIGHGIIJIGIIIIHHCEEHFFFFBDFFEF
@0JM
GTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACAC
+
B@BFFFFFHHHHGIJJJJJJJJJJJJJJJJIIJJIIJJJJJJIJJJJGJJIIGIFHHIIIJJJJIIJJJGGJJJ=FGIIIIGHIGHHHHHHHFFFFFD
@0JN
GGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGC
+
@@@DBFFDFDAFHIIBHHHIIE@EEFHE?C?FHEBHIDGHGFFGH?FEG@FDHIE@FGHGHIHHHFEDEFFFCABBCCAA>C35>@:5@CBA@BCCA@<??
@0JO
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTG
+
CCCFFFFFHHHHHHIJJIJJIJJJDHGJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEDCEEDDDDCDDDEDDDDDDACDBDDDDDDDDDDDAC
@0JP
CCCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTC
+
CC<FFFFFHHHHHIJJJJJJJJJJJJJIJIJJJGIIHIJICHIJIJJIGIJJ?EHGFFFFFEEECCDBDDDDDEDCDDD@CCDDDDDDDDDDDDDDDDDCD
@0JQ
TTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTT
+
CCCFFFDFHHHHHJJJJJIJJJJJJJJIJJJJJIJJJJJJJJJIIIIJIIIIJJJJIJIJJIJJJJJIIJJIJJJJJJJJIJHGHHHHFFFFFFFEEEEEE
@0JR
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATC
+
CCCFFFFFGHFHHJJJJJIJIF<EGDHIIHHGHIIJJIIJJJJJJJIJJIJJHAEEFFFFFFDEEEEEEDDDDDEEEECCDDDDDDCDDDDDCB?CDCDDC
@0JS
GGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
@@@BDDFDFDHHFGCFFGIIJIIJHEDGIDGEIGIGEGHJIIHGJIHIJEHIJJIIGJG>CGEHFEEHHFDFCD6@AD?BDBCDCCCDDCC4<CDDDDC
@0JT
CTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCT
+
CCCFFFFFHHHHHJJJJJJJIJJIJJJJJJJJJIJJJJGHIJJJJJJJJJJJJIJJJJJJIJJJJIJIJJJIIJJIGHCHIJJJJHHHHHHHFFFFFFFE
@0JU
TGGATCTACAGGTGGGCCTAGATCAAGATCTGGTCCTTCATCCATGGGTCCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTAT
+
@@@DDFDDFHHHACGIJJJGGGICGIIIHIHIFHD@GGIIJ@FHGHIIDGGGHIJJJGE@BHIIIIJGHHE=<D@DFFEDC?BCACCDDDDB?BBB@@@BD
@0JV
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@@@DDDDDDDB?FCBBGEG?G@@GGDD>AEGGDGDHCG@DAGG??B00?8?FB4=<F8=7C>CE8=DCC>AE=;86>>>>:@B?@C5>>@CC(5@?3>@B(
@0JW
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
CCCFFFFFHHHHHGHIJJJJJJJJJJJJIJIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ?EEDDFEEEEEEEDDEEDDDDCDDDDDD
@0JX
GGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGCTTCTGATCATAGG
+
@@@DDDD;F?<;3CFE>EHBAHGHFGBCE;FGEFHGE<8?DFD>BDFBFG=/8.5CBBEB;@;B@C<85;@BBCC:>CC@?BCACA@B?BCCCEDADCA>A
@0JY
TGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTG
+
@CCFDDDFHHG>BDHHIGCHHHIIIGHGGJJBHGEIHEFHIIIIJJCGHDDGHGIJJIGEGEHJIIHIGIIHDAEC@C;@C@;>3>CAACCCCCCCCDDDD
@0JZ
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
@@CFFDEDDHHFHJAGHIIIDGIIJJJJEGIIGIJHHHA<BDDE@CDDDDDDDDDDCCCDCDDDDDDCDDDDDDDDDDDDDDDCCCDDDDDDBDDDDDCD
@0K0
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
@@CFFDFDDFFHGBHAFHIIJIIGIGIGGGGHJJJIGGHJHHIIIIIG>FHEGGGIJJIIIGHB=BB>CCAA;ABBBDBCDDDCDDDCCCCBDB@B@BCCC
@0K1
CTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAG
+
@@@DBDD?FFFDDCG4CF<I>DGHI68CF@DGBGAF9C@9GFCB9@D@F>DBGEGB/=BFEIGF>=)>C@EH>?E??CHEE<DDE>ACC>>:?@BCDC>
@0K2
GAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGG
+
@?@FBBDFHHFHHIIDIGGGGHEIIJGGIGDG>F@DBF@6@FGB>FFB=7=;@BG;;C>EEDD><>?=:>@?,5<AA:>C@:??B>BC@@CCA@88?<@>>
@0K3
CCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATT
+
@BBFFDFFHHCFFHIJJJJJJJJJJJJJJJJJJIJJJJCHIJJJJJJJJJJJJJJJJJJJIJJJHCBBCA>C>C@;?BBDA<>>>;@@@>A?>>9)5?CCD
@0K4
CCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
CCCFFFFFHHHHGIJGFIJIFIIIIJIGJJJFDHIJJJJIGIIEGIFHEFFFFFFECEECDDDDDDDDCCACDCDDDDDDDCDDCCDDDCCBDD?CCCDD>
@0K5
CGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTC
+
<?+ABDDDDFHHHGAEDFHIGGHIIDGHIGGIGIEHIIGGGIBGIIIGGIGGGIIIIIIDIIGHEHHHHEEDFFFECEE>??BDDCDCABACD@C@ACDC
@0K6
GGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGC
+
@CCFDFFFHFHDHJGJJJIJIGFHIHGIJGGIJJJJJJIGHGIHGJGHIJHJGIHHHHGHDDEFFCAEDCDDDBDBDDDBBBCDDD@CDCCDCDD@CCDCA
@0K7
GCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCT
+
@@@FFDDAFHFHABDBGGHG@EBHIIIGEIEHHBEBFAEG=FDGBGGIGIIGIIIGGHCBF>@CFCEEEG>E;BB8=?A@ACC?CC>@@CA?C<AACC3<B
@0K8
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGG
+
@@<DBDDBDHFHHHIIEFHIHGDIIIBHIIGIIGCCGCFHGIIGGICDB@AFHEHIAAEHF==BB@@;AE;C@@ACACCDDD<CADDDDDCDCCD>>>A>8
@0K9
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
?@@FD@DBFFFHFEHGHHIJJJGJGHGGIGBBCGGGIGIIGIGIIIGIGIIBCHHGEIHGHJII-=>>BCCCDDCACB?BBDD?ABDDDDBCCCDCCDDDD
@0KA
CCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAA
+
@@?D:DD>FHDDHFGGEBCHHEFHC9D:CAFHDFFGHIHIEGGGGECF4?DA>?D?DFGH@4=C@FHGHACGGGIGIIF@CCD;;7?7;@;>CB?BBBCC
@0KB
CGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
@@<DDDDB;FD?DGFFFHIGIGHEGGGEGHGFHDDHIIGGIBGGIEGECHG;FEHGH>EFFAADBDC;;;AA@@CCB?,859ACCA@><0<@BCCCCCCCC
@0KC
GGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTC
+
?<14ABDBFF<CFGIIGGIHICHGEHICEECEGEDHGGGIIBAGG@GGHGIECEIEHEE>BCCB>?@<@CCB?CCCDCD@CACCB@?BBBBBBBBBCCACC
@0KD
CTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCAC
+
CCCDFFDFHFDHDHHCDFFJIHIIDGHHGGF3DGHIIGGGIJJJJJIIIJIIJJJIIGGGGH@EGHGHHCH=C@DEEFFEFEEDACDD@@DACCDDCDC
@0KE
CCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCAT
+
?@=DDDFFAHDDHIJJJIIJJJGGGIJJIJJJJJIJJJDIGICHIJGIGGI>EEAHFFDDBBDDDDDDDDCCCCDBB>BDDDDDDDDCC@ACDCCDBDDD
@0KF
GGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGG
+
@<?D?B???BFHDHIABHEAGC:AAA<<9C?FBG???*:1?FDFD9B@@DDGGIGGDD>F???FBBFHB=5CAGHIGA@3(67A=C@EEE;=B>BB;;;5(
@0KG
CATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCT
+
@?@DDDFFHHHFDAGHIIIHBIHHIIEGEHIIIGGGIGGHDDHCFEHIIBBDBDF;DGIIIIIGHGGIDG;@GGGIGGHIEFHHHEDEFFFCCC@BD@<;?
@0KH
GTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGG
+
@@<D?DDD<BFDFHE8DE6?A<=??86?6?@BB06?>C>8>@<8BBB9@5<B85829(++:@CC:@>A@A:>B709@@CC?C?>>@CC<?B<??4>:>@@?
@0KI
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
C@@FFABDHHHHHIJIIJIGIFHBFHIJIIJIJIJJIG@FHFEHIJEHIBAGHAHEEEEEHFDEFFDDDDDDDCCCCDCDDCDDDDCCDCDCD@ACCDDC
@0KJ
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
B@7BDDFFHGHHHJJJJJJJJIJJJJJJJJIBHIIIJJIJJJIIJIJJJJJIJJIJIJIHGIHJJHHHFFFFFFEEEEEEDC>CDDCDDDDCDEEEEDDDD
@0KK
CCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCAT
+
@CCFFDFD?FHHHGEGBBIHGDBHIGGGI?FGGGGGIIIIIIIIGGGBGGHIGHIIIGGHHGHGDDHGIGIIIGHHHHHFDFFFFEECC6>B;ACCACCAC
@0KL
CCGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTT
+
CCCFFFFFHADFHIJJJJJJJJJJIJJJIJIJIIJGIIJJJJJJJJJIJJJJJJIJJIJJJJHHHFFDDEEEDCBBBD?BBDDDDDDDDDDDDD9>BCEED
@0KM
CTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCG
+
CCCFFFFDHHHHHJJJIJJJJJJIJJJJJJIJJ:DGIIGGIJJJIJIJJIGIIJJJJHCHHFFFFDDDDDDDDDDCDDDDDDDCCDDDDDDEDEDDDDBDB
@0KN
ATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTG
+
@CCFFFFFHHHFBHIJJJJJJJIIGIGGIII?BGIIJIJGH@HGGIEIIJJIGIHGJJJJJJ;FHEHGIIIFHHHAHFFEBD@CEACEEDDDDEEEEECDD
@0KO
GCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTC
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJFGHIJJJJIJJJJIIJHHHHHEFFFFFFEEEEEEEDDDDDD
@0KP
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHHHHHJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJGIJJIJJJHHHHHFFF>BDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0KQ
CCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCTGCCAAGTCCCGATGAACGAGCTTCATCTCGGCCAGATACTGCATCCCCTGTG
+
;@<DDFFFDFHHGIIJIGHIIIIGIJIIJJFIGJFGJJIIJIIJECG?GHEC=GGIIIGEBEEEDDDCCCDDCA@C?BBDDDDDDDCCCCCCCDDD@@C
@0KR
TGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTG
+
@@=DDDDEAFFDHIIIB@GGDHIEHIGIIIJAGGEHIIIIIBGHCHEDFDFDEEE(>?@BABCC@CDACDACDDD<9009<?C>A@C:ACCDDCACCDCCC
@0KS
TTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGAC
+
:?;DADD?DFHFF)@EEBEFAFHFEEG8CFHIGHGEAHFECC@>C@>A@=C@ACCCACAC3>>C+::@CA9:ACBB?8?C>@4>@>CC<<@?BCBCC:@>:
@0KT
GTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGC
+
@@@DDEDDHHBHDFAHHDEEAHIGIHGIGGJ9BGHIIJGHGIJJJI8@DGHGIIIJEIFAH=AEDDBBCEDEC>CD>CDDEACCDACCDA?AACADDDDEA
@0KU
TTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
CCCFFFFFHHHHHHJJJJJJJJJJJJJJJJJJJJGJJJJJJJJIJJIJJJJJJJJJJJBGIJIIJJ;CEFFFFFDED?ADDDCCDDDDDDDDDDDDDDD9
@0KV
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
@@1B?DBDFHDHHEGHIIIIFFGIEGD@F?EHHGDH>GEAHGIIHE?CEHE@GCAAEHEECC@9CCCCCC<C:@ACCC@C@?CCAC>@>ABBBC??CC:>C
@0KW
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
CCBFFFFFHHHGHJJJJJJJJJJJJJIJHIJJJJJJJJIJJJIJJJJJJJIIJIJIJJJJHHFFFAEEEEFEDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0KX
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHGHHGJIJJJJJJIJJJIJJCFH@FHIJHIJIJJJIJIIJJGIJJJJJHHHFDFEEEECDDDCDDDDDDDDDEEEEDDDDDDDCDDDDBDDD?
@0KY
CCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGG
+
CCCDFFFFFFHGHGCGHEFGHHHGHHECHIGHBHEHGGI@DEGHHIICGIIIC@EHHHHEEECCBCCDD>;.;C>>>?CBDCDDDBBCCCCCD?CDDDDCD
@0KZ
CTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTT
+
@@@BDFFAFHHFHGGIIBHHGHEHGEFGEEBGGEGDHCEEGFDGGEDFGIIIGHGBD=BCGF>FCDAEIIGEHEFHHHEC@CEFBEDA>;@CCACCCCDDD
@0L0
GGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTG
+
CCCFFFFFHHHHHJJJJJJJIIJJJJJIJIIJJIGIIJJJHIIIJJJJJJJJIJIHJJIHGEHIJJHDDDBEEDDDDDDDDDDDDDDBDDDCDDBDCCD:A
@0L1
CAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTGCTTATCTTTAGCCTCCA
+
@@@FDDDDHCFHHIAABEFEAFHHGIIGHGIHIIFHGEHGGIGIHFGIIGEFFDHI>FGHEGHGIHIICGHGG>CGIGGGIIGCEH>AEEFEF@BBC;AE
@0L2
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGGGGTATCATAAGCACCAGTGCCAT
+
=??DBDEDH??DHIBBGGFHHBEEDGBD<????GGDAB@D?BDBFGDGE@D@FCH)<;-@@=?;?AEDFFECDECC(9;,8A@:>ACC@CCBBC:@A:@A
@0L3
CAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGC
+
BCCDFFFFHHHHHJJJJJJJJJJJJIIIJHJJJJJJJJJIID@DDDDDDDDCCDDDEEEDDDDDDDDBBDBDDDDDDEDDDDDDDDDDDEDDDDDDBDBDD
@0L4
CTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATC
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJHJJJJJII=77=CHFFFFDDDDDDDDDDDDDDDDDEDDDDDDDDD
@0L5
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTT
+
@@@FFDFFHFGHDHIJJJJIJJIJJIJJIJJIJJIJGIJFGHIICBFIFGHGCFGIIJJEAAEEHFFEFFFEEEE@CCBDC@ACCDDCCDCDDDDDDDDDD
@0L6
TTCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTC
+
@CCFFFFFHHHHGGJJIJGGGGGHEHHHIICH?DDGE?B@DHGGGFHGFIHB?FEDHGIIGJJEEGEHHGDDHGHJGHHHHHGHFCBDCDDCA@CCECDDA
@0L7
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJGIJJJJJJJJJJJHHHHHHFFFEEDEEEDDDDD?BD@DDDDDDBDDDDDDDDDDDD
@0L8
CCTGGGCATCCCTCTGGGGCTATCTAGGGCTTGCTCCTGCCCACCATGCACTTCTCTTGCCCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGC
+
?<@D;?;;F;?FD@FB<C>FHCDD>E@FCGEEII4BGEGE@G<6:?D)B>BF@GFCFA=EGHHAEEEBE7??6@@@>ACCC5?C>ACDCC??A@?A
@0L9
CTCGGGACAAGCCGAAATCCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCCGCCAAGTCCCGAAGAACGAGCTTCATCTCGGCC
+
?;=D:DD??A<2:@1CD11118?@?:**::?BD<B?.76ADDA=@=77==A)?@3).;..(((((,,3,,<>>A:&5&&09<30&)5(++:4>:>??9
@0LA
CTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATC
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJIHIJJIJJJJJJJIJJJIJJJJJJJIJJIJIJHHHHF?DCCDDBDDDDDCDDDDDCDDCBD>CDD
@0LB
GGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCA
+
CCCFFFFDHFHGHIJJIJJJJIIIEHIHIJJJJJJIIIJJIJFIIIGIIJJJJJIHJIGHFHGHHF
@0LC
TGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@@@DDDDDBDBFFGGGGIIA?GGEEGCH@@F>EEHEGIIHGA:?DAE<<B>F8.=@CFA;=FGGHGG;)=CAEHECC@;@B@CCCCCCCC;@8=;@;<>>
@0LD
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFFFFFHHHHHJJJJJJJGIJJJJJJJJJJJJJJIGJJJIJJJJJIJJJJJJJJCGIIIG=EEHFFFFFF@CACE>@D?CDDEDDDDDDDDDDDDCDDD
@0LE
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTT
+
BBCFFFFFHDHHFIIJJJHIIJJJJEFBGIJIJI>FHIHIGGIGGGFHHJIDGH3BBEGHEEF5AHF9AEEDCD5;?BBB@BDDDDCDBDDCCDD@CDDDD
@0LF
GGCATATATCCAAGAGAAAAGATTTCCCATAGCAGCACTCCAAAGGACCATGTGTCTGTTTTAGAAGTGAATATTCCTTCCATGAAGGCCTCTGGGGGCAT
+
@@@DDB?DDB<AFFHHAFG?F;FGGIDGH@BG@BBE@GEE@HGIII?F@HBF?B9BF>FGH@=FHIG7=CDG@DGEAEH?C=?>?DDEB?C;CC@;8?=5<
@0LG
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCG
+
CCCFFFFFHHHHHJFHIIIJJIJJJJJJJJJJIIJHIJJJJJJIIJJGFHHHFFFFFEEEEDEEDDDDDDDDDDDDDDDDDDDDDDEED@CDDDEEEEEDC
@0LH
CTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTC
+
@@@BDDDD:AFBDAE<AAFH>>?C>F@F>H@DD?FBFBFHIHDGGGEH8D88=8=FAFFF@CEGIC?EHHA>;;CD;B.>=BCBB?@CB<><<A>::@C(4
@0LI
CCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTTCCAGGGGCACAATGGGGACCAGTTGAGCAACTGGTGGTGGAGGCTGAGGCGGAAGGCCTGGAGGAC
+
C@@FFFFFHHGHHGIJGJIIGIIJDEHHGBGIIIJGIGGIJJBFC@BFEGHI=B@CCCH7;??C9>@CC(;?';;5?<??<(88<@BDDDBDB(<?ABDB?
@0LJ
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
@CCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJIIJJJJIJJIJJJJJJJJJJJGGIIIJHHHHHHFFFFFFDCDBDDDDEDDDCDDDEDCDDDDDDDDDDD
@0LK
CGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCTCAGACATGTCTCAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJFHHIIJJJJJJJJJJIHHHHHFFFFFFEEEEEDEDDDDCDDDDDDDDDEDDDDDDEDEDED
@0LL
CTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGG
+
CCCFFFFFHHHGHJJJIJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJIJJJAGH=DFFEDCCDDDDDDDDDDDDDDDDDDDBDDDDDDDDDDDDDDDDD
@0LM
CTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATG
+
CCCFFFFFHHHHHJJJJJJIJJJIJJJJHIJJJJJJHHHHHHBDDFFFDEDEDBDDD>ABD=BD8ACDDDDDDDDDDDDDDDBDDCDCDDDDD@B<CDE
@0LN
CTCTTTTTCCCCACAGTAGAGGCAAACTTGCAAATGTTTTCCAAATACAATATGCCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGA
+
?;1BA=?D?DD;FE=EA<B4:+<AAFC91::?9::CGFG;FF>B?D>@FCB?<DDH?@FC=@<=@@@F;@@EC;;D@=;(=??B?6@CCAC@@C:;5;5
@0LO
CTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATC
+
@@@DD;DDHADFHGGIIEH?CDEDHGEHBBF:?C?FFHFI>FDHIIIIIIEGDAGGGG>=CFEEHCCFHEGA7@D=7=AHEEEE@?;CC@@BCC@;>5;;
@0LP
CTACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCAAT
+
CCCFFFFFFFFHDFHGIGCGIHIIEFFEFIIHJJJIIGCHGGIHGGGDGB?FFFHIHJIDEFHEHGIIHHEICDHIJJJDGIGGGGGI@EHEEFFHHFFFD
@0LQ
GTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCT
+
B@@DFFFFHHHHHJJGHHJJJJJJJIJJJJICGIGHGIFIIJJJIIJGJIGIFGIJIJJJJGHF<@;CDDCCCDDCDDDCDCB?CDCB>@BDCDDCDDDDD
@0LR
CACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTC
+
@@@FFDDAFHHHHJJIJIHJCHIJGIEHIJJJHIIIJJIJIIJIB@8B?CCC@CDDDEDCDEDDCB>CDDBDDDDDAAACDCCDACDCCCDDECDDDDD9B
@0LS
CCTGCTCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
CCCFFFFFHHHHHJJIIJJJJJJJJJJJJ?DGHIJGIIIIIIGHJJJJJJJJIJJJJHHHFFFEEECEEDDDDDDDDDDDCEDEEDDDDDDDDDDDDDCDD
@0LT
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTTGTACTGTCCGCTGCTAGTCTGATAGATGGGAGTTGGA
+
@@?DDBADHHHGHIIJJGIHIJIJJIGCIIIIJIIJGIIEBGHEHGIHIGHGIJIIGIHIJJJHGCEHGEEFDC>?BDCC;CDDDDDDCDDDBABDDDDD
@0LU
AACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGT
+
?@@DDEDAHFFHDGD@FDEHGEG?CCGI>FAFAGEHEGHC@9:??FH<FGAFH@GGHBFHF@@FDCEHGCG?=AHCAB:B>CFCECDCEE?BDCCBCCBD
@0LV
GTTTGTCCAGCCGGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCACCAGGATGGAAAAGCCTGTGTACAGGGCT
+
@@@DFFFFHHHHHIIIIGIIHIJIIIFHIIIJJJDFFHIJGIHIJAAEEF@=2;ACCAB@BD;BBD?CD@@>CDDBDBDDBDDDDCDDCA@C>CC>@CBD1
@0LW
CTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGTAC
+
<@@ADE?D?FDHHIIIEGF>EBC@FHIGHCGFHH<9CEBHBCDEAHIB:FFH=A8@EHGEAH>CHB'93=@ACC>;CAC@CCCCCCC>ABCCCCCCB99@B
@0LX
TTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTT
+
CCCFFFFFHHHHHJJGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHJJJJJJJIJJJJJJJJJJJJJIIJJJIJJHHHHHHFFFFFFFEEE
@0LY
ACTGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTG
+
?B+=ABDEHHHHHJJJGIJJJJJJJIJJIIIJIGIIJJIGIIJIJJIFIGJJJIJCGGHIGIJHH=BD@CDDAACDDBBDDDDCDDDDDDDDDDDDBDBDC
@0LZ
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
@@@FBDDDFDCFHAEHIHIGFGGHHIIIHHGGGBGHGIEFIIIBDFFEHGGGGIEHIIIGEIGGHGHIIIII=.>B=C@;.>ACACDCDACA5@ACDBD9;
@0M0
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCC
+
CCCFFFFFHHHHHIJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIJIJJHHHFFFFFFEEDD>BD@CDDDCDDDDDDDDDDDDDDDDDDDD
@0M1
GGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
@@@DFFFFGHHGCFG<EHGHBGGIGFEHHGHCH:BHFHEIGGHIEHGIIIHIIIIIGGIIIH<EFDFFFCC@CBBCB<CDECCCCCCCBB<BBCCCC@C@
@0M2
AAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCC
+
@C@FFFFFHHHHHJJJJJJJJJJJJJJJJHHGGJJIIIJJJJJJIJJIJJIJJJIJJHIIJJIIIJJJJJFIIEIJIIJGHHHHHHFFFFFFEEEEEEDDD
@0M3
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@@@DD>DDHHHB<FGFIIGCGFHIGCEHGBIIIIIIIGIII4?DBDHGGIIGIFGBFGHIEGI@FCEHGGHIHHHFFEB>/8=BAC;@ADCBBBCCCCACC
@0M4
CATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGT
+
?1?DD;D;??DDD<4?<3CGBIIC?+ACFE??<E:8DG=F<@<?>9*9*098D48?*<;CC).).8@)-.;;:ED<;7;ABBACBAA55>AAA3<:@:@:<
@0M5
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
888ADDDD?CF><CGB<GADAFG??GDEGD?:?F1?0::BG<??9D9FFEFF<==BFD84.>@@@@A@)7.7:AD7@6;63>3555;5:A:;@B(5:<5+)
@0M6
GCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCC
+
CCCFFFFFHGHHHJHAFGGHIJIIIJIJJJJJIJJJFHIJJJJJIIGJAHHHFFFFFEEEEDDEDDBDDDD@BD@DDDDDDDDDDDDEED@ACDDDEEEED
@0M7
CCTGGTCTGTGGAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCC
+
CCCFABDD?HHFFGFFFHIJJIHIJJI<CHHIGGIDHIIGGHGHJGGIGEGHIHIIIIJJJJJGIJEACDH@FGIGAEEEFHEEHECFEFDFCECCCEDD
@0M8
CCCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGC
+
@CCFFFDEHHHHHHIFHGIJJJJJJJJJJJGJJJJIIIGIIJJJJIHGBFHGIGIJJIJIIGHEHIJGICHIJJGGGJGIEHHDDFEFFEDECEEEEEDAC
@0M9
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGT
+
CCCFFFFFHGHHHIIJJJJJIIJJFHIIIJJJJJJJGHHIIJFHGCGHHIIIJEGHICEHHHGHGFFFFFFE>ACCBCBDDDCDDDDCCDDDDDCDCDDDD
@0MA
CTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTGCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTT
+
@@@FFDDDHHHHHJJIFIGHGIHIIIFGHIIIIJIIJIGJGIIIIJJIHGGHIJIGGCHIIIJDDDEHJE;BG@FAGGAH;CHE;CEHHFHB;BCCDDCCC
@0MB
GGGGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
:?+4BDDFHHHHHIHIICFH@HHIIIIIIGIIIIICFGHIIGGIIIIIIIFIIIIIIIIIIIGGGHGGHHFFDDDDDCDDDAC>CCBCDEEDDCAACDD
@0MC
GCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATC
+
CCCFFFFFHHHHHJJJJJIJJJJJIIIHIJJJJJJJIGHIIGIJJGJJJIJJJJJJJJFJJJJJIIIHHHHFF;AC?DD;BCDDDDEDDDDCCD>BD>CCD
@0MD
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
@@<;DD@D?FFDFGA<EBFECDGECGCGDHEACEGGGII<DFGIIGGGHCCBFD@GIIGGBHACAC@?DEBD@ACA>;ACC>CCCCAACCCBB?>?BB(5>
@0ME
CCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCC
+
CCCFFFFFHHHHHGIJJJJJJJJJJIJJJJJJJJJIJIIJJJIJHIJJJJIIHHHHGHHFFFFDDEEEDDCDDDDDDDDDCDDDDDCCDDDDDDDDDDDDD
@0MF
CTCTAATCAAGTCCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTAC
+
@??B?:=AFAC<AF@<A?FH?CAFHC4CAE>H?CHEC:?@EEE?D?:1?C??DF4?:<BDAGF<?8*/0-==BC;.78@AEEE7.7@CCCE=>?B;?@DD
@0MG
ATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGT
+
@@@DD;DDHHHHHIHDFHEHIE?FHIIGECCHGGHIIIGGGGGCCHH@FHDHIIIIBBDAAFIIGEA@EECHFD>B;7?@CCA@CACCCAA(5<>CDC@C(
@0MH
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
@@1AB=DDFHFFHGIDCDBB?<EFF@DDCGHG:EFEEECD9FFBDHDCEBHEHEGEBCBBCCCB9<ABBBBB?C@B@B52:4::@CBCCCCCCCA>@CC
@0MI
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGGGGTAACTAGTGGGAGGC
+
@=?DBFDFHHHHBGIIADDHDEGAH=FHIIFIGIADABGGDG>DBDHGEBGCHEEHEEGGHICAHECHHHCEEFFFFEDDBB'05<)5ACDD@:@B?A?>B
@0MJ
GTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCG
+
@@@ADDD>DFFFFI@GFDGC+C<:3CAE<92AG>FIIE99:8??FAG???FFFD;2B8=8;=C@FEFFA;;)7?=;B>BBDD@(;A;5>@>;8=B;<?@A&
@0MK
CCTGCCTGAGTGCGTTCCTATGGCCACCACTGTGCCACTTGGATGAAAATCTGCACAGTGTCCTGGTTCATCTACCAGCCTGGTCCATTCCAGCCTGTGTT
+
CC@FFFFFHFFFHIHIJJIJJJIJJIJJGIJJGIIJJJIJJJHIHJJJJJIJJJJJIJFHIIICHIGHIGIIEHHHECEFFFDCECDDDEEECDDCBCDCD
@0ML
CATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGG
+
@@@DDDDFHHHFHHGHGGII>FBEFFGHCEHGIEIIIIHHGII>FGIIEGIGIIIIIIIHIIIEGHG?E@DDFDFEE;AACCDD55@@CCBD(9@BCDDD
@0MM
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTT
+
@?@DD=BDFFHFDGHGFGDIHHHIIIFGHGGGGHGEGFDCFCFFFBEHBHFFCCEEA>BBBCCCCCA?<5<?AACCDCCCCC?ACCB5>B?@C>>ACCCCC
@0MN
GTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTT
+
@@@D;DBDBFDF?;ECFHIGGIHGIDDG@GGFGGHFHEA@6?B<FAFA7@HI@@CEHHH;@CD@BCC@BBBBBBA:ACC>@CCCCCCCCC>A@CCCBCC9<
@0MO
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@@@DDEDFHHFHGIIIIGGIGFE@CGGIIGGIEGGHIIIIIIGGIIBFHGIEHHIGGIIIIIIIIGII=DHHHFF@CEEDCEA?BCCDDCDDCCCDDCBD+
@0MP
TGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTT
+
CBCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJJJJHHFFFCE>ACACDDDDDEDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDDEDDEEDDDDD
@0MQ
CAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCAC
+
???BDD2B:DDADE@:<2<AA<<CF@3A9?:CD>EDFDD@D@9DBDDIIIDDDBDADCEI8BBCECDIED7ACCC?CDDDDD;@AA@@;>AA>A>55;>>
@0MR
CTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCT
+
@CCFFFFFHHFHHJJJJHJJJJJJIJJJJJJJJJIJGIJJJJJIJJIJJBDGIJJJIIGJJJJGIJFHIJGGIJJIHHHGGEHFFFFFFEDEEEDDDDDDD
@0MS
CAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCC
+
BCCDFFFFHHHHHIJJJJJJIIJJJJJJJJJHIIJJJJJIJJGIJJFIJIJEHIJDGIJJJJJJIIJ@FEIJIJIJJHHGGFFF7@DFEDEDDDEEEEDDD
@0MT
GGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTT
+
@C?DFFFFFFHHHEHIIGIIIHIAFHIIIIHGGIIHIIIIIIIIIIIIIIIGEHHHFCFCA@DDDCCCDDDDDDDDD:ACDADDDEEDDDDDDDBDDDBCE
@0MU
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCAT
+
C@CFFFFFHHHHHIIIIJIIGCFHJIJJIJIJJFHIGIJGHGGGGHIIEHIJIIIIIHGEHFFFCDDDDDDDDCBD@CDD@CDBDCBCCCDE
@0MV
GTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGT
+
CCCFFBDDAHFG>HIGGIIFIJGIGIIBBDDCDEEDDD>>>CCDDDDDD@5@5>ACDCCCCCCDC@>CDBD@;@@D?BDCCCC@@CDDDD8ACCDDDCCA4
@0MW
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFDDEFGDFHHJEEGGIGHJHIIIJFIJCHIHI@GIJ?GHI?FHIBFHDGIHGAHC@EEHHCECDFFFCEDD@ACDBB;?BDCDD@CDDACDDDCDDD
@0MX
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATC
+
CCCFFFFFHHHHHJJJJIIJJI@FHIIIJIJGGHIIJJJJIGIGEIJIJJJJIHFHHFFFFFCCEDEDEDDDDDEEEEDDDDDDDDDDDDDCDDBDDDDCD
@0MY
TGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFDFFFHHHHHIIIJJCHHIJIJGIHIGJJIIIJJIIJIJIGHIIFHGGIGIJJCGIAEG=HEHGE@EDBDECCC;??;CDDEEDDDDDDDDDDDDDDC
@0MZ
CATCCACTTAACTGGCAGCATGGCACAGCCTCCCTCTCTATAGTAGCCCGCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGGCCACTCTTC
+
=8=BB3D8A4AD,2AB3CED+<3A9A++?E):DC>)::BD9BD0**9*9DAD@6C).@=4=7.)7.559?@(5;5>?==?AA:>>>>93(((+:A?A?:A>
@0N0
CTCTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACGCTGCCACTGACGGAAGTTCTCATAAACGTCCTTGGAAATTTTGGAGCGGTCACCTAGGGAAGG
+
@@<DDAD<F>F;<CFEAHEIIGGGIIIGIDH@HHC<???DFFFGHGGHCEGGEBH>B>BCBBCAC=>;=?CCCCCACCCCCB39?>B55>A4>>A??>?BB
@0N1
CTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTT
+
@@CFADDDAFHFHJEGGHIJIHHGHBGHJJJJJICHIIIJHIGGGIHGGCGFGHGHEEFHIJJIGGHEGGHH>DBCDED@@CCCDCCDCDC>C?CDDCCDE
@0N2
CCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCCGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGAT
+
CCCFFFFFHHHHHJJJIGIJJJJJJJJJGHIJJJJIJJIIJJJJJIJJJJIIIJIGIIIJIIIHHHHHHFFFFFDDDDDDDD?CDDBDDDDDDDDDDDDDB
@0N3
TGTCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGG
+
@@@FFDDDHFHHDHIIJJIIIGIIJJJIJGJJIGCFGGGHGGGHGHIIJICCHGIJHHGHDH@BDE;?@CCCCCDDECB@?CCCDEDCA=<>AD>BCDDCC
@0N4
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
CCCFFDFFHHGHHJJIJJJJJIIJJIJJHGIIJIGIJIHIJIIJJIGIJJJJJJIJJJIJHHFFFACEEEEDDCCDDDDDDDDDDDDDDDDDBBDDDDDD
@0N5
CCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCC
+
@@CDDDDAFHHGGHFIEGGHGCHIGIGIIGHIDFEGEIHIEHHHCEDE@CCECAADBDDDDCDDDBD@B9980:AAC:>CDABD:>>CACC?ABBBBCDDC
@0N6
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFFFFFHHHHHJJJJJJJJHIJGIJJJJJJJJJJJJJJJJJJJJJIIJJJJJJIJIJJJHJJJIHHHFFFFFFFEEDDEDDDDDDDDDDDDDDDDDDDD
@0N7
CGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCA
+
@?@DD?DDDHDH?@CA@DHHGHABCC@FHCD9:C?;DDEGEG?0?F;F?DC07;44:?3;/=@5:<5<?@B>9ACC39@<5A@D@C@A89AC3@:@:CA:
@0N8
CTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
;;?DAABDDHDHFB=FGIIGGEEHGG>FFGHIIIGIGGII@H?BGGIGGGDGDH@GCAC7CF==@AEGCDHEHGFHFFDDDFEACEEA>;@C;AC@AAA
@0N9
CCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATT
+
CCCFFFFFHHHHHJJJIGHIJJIJJJIJJIIJJHIIJIJJJJJJJJIJJJJIJGJIJIIJJJIJJIIJJIJIIJGJIJJJJJIIJJHHHHHGHFFFFFFEE
@0NA
GACAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTT
+
CCCFFFFEHHHHHJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFDDEEDDDDDDDDDDDDDDDDCDDBDDDDDDDDDDD>B
@0NB
GGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTC
+
B@@DFFFFHHHHHHIJJJJJJJJIJIJJJJJJJJJJJIJJJJJJJJJJJJJJEHJJJJJJJIIJJIJJJHHHFFFCEEEEECDEDDDDCDDDDDDDDDDD
@0NC
GGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTTTGAGGCAT
+
@@@<DD?DDD<<8::A+2<<F<E9?E<CCFDFECFEIB310BF<?B0)?B;;DFB<FFGA)7=;C@)==EECF;(..(()51(665((,5>(:(,,(5?(
@0ND
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCT
+
CCCFFFFFHHHHHJJJJJJJJHIIJIJIJJJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFDDDDDDDDDDDDDDDDD
@0NE
CTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATAT
+
@@@D?DDDFF?ACGF@EA?CF<E<CHH@<82???:DFEBG<?D?DCF9BCCGD=;8;68;CF8@FE:CD=CE)==7?;7??8=;;@ABDBEBB@>?BAA>:
@0NF
AAATCACCAAGGCCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTT
+
???DDB?DDDDD+<EDBBE@9,?E<CD<E???E<EEEDIEFEE4DDDED?<90*?DDD@DADDCDCD<B;CCA3.=@.=;;;;3=A9.?<';2=>>A5>>A
@0NG
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@?@DDFFFHHGHHJIIBEGIGIJIJIJGHHIGI*?GHGIIJGHIJIJFGIIJGIIJJJJIIIJHIIIHHHBDDFFEEEACACDCACC9ACDDDDD8A?BCC
@0NH
CCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCAT
+
?1?DBB3A<>FDFIBEE@E?4AB+?;C@CDB?FBFF@>D??4BDBB9F;:B9?*9?=:B=:=@FA3CC@A7@ECEFFF@D>B>?>@??@9>?BA9,:(5>
@0NI
CGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCAT
+
@C<DFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJIJHHHHHFFFDEEEEDDDDDDEEDFDEFDDD
@0NJ
GCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGT
+
CCCFFFFFFHHHHAEHIIGGIFCFEHJJJIIIJIGG?DGGIIIIGJGGGHEHIJGIEE5?H@CEEF?ECDDDB@DDD@BDDDCDCDB8<9ACCDD4>>@C@
@0NK
CCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCG
+
@@@DDDDDHHHHFBB?@E?CFEBFEHGHIGACCGGIIIGG@D@BEB?BFBDAGHIBDDF<FF<C@CFACFGICE==?AHB=A@>D=A>3;@?CACACC@C>
@0NL
CTCATAAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCC
+
@@+ADBDBB??BBBADGHGEEHEG@FHHCG??D@GGGCH<DA@BCHIIH>FCC=C;@GHFE=CEHHEBHEEB@ACCCACBCDCDDBBBC<9:>CCBB555
@0NM
AACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
@@@?DDAD;C+28AE;A:CHFHIFBHCCDB@BFD?FFFD07788C;@C=F>EE@9CEEEDFDDD>>@;>6==,;@;;35::5,:>:A>AAB<@@?>@BD
@0NN
GGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCT
+
CCCFFFFFHHHDHIJHIJJCGHIIJJJJJJGHIJJIJIJJJJIJJIJJJJJJHIJJJJJJHHHEFFFFFFDDDDDDDDDDFDEEEDDDDDDDDDEDDDEE
@0NO
GGAAGAGTTTGGTAAGACACGTAGAACACAAGTCACCTAACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGG
+
@@@DDDFDHHHHCGGHIGIIJGHEFIGJJJJIHIGGIJJJJIJHEGGIJJIJIIGIGEHGGEHHFHHFFFCECCEDCACDCDBDBCBCDDDDDB>@CACCB
@0NP
GGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIIIIIJJJJJJJGHIFIIIIIJJJJJJEHFHIIJJIIJJDHIG:@DDEEDCCCDDDDDDDDBDBBDDDD5
@0NQ
CCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGG
+
?@+ABDFDDFBHHJHIGGGIGIIIIJJGHIGGEIEIJJGHGGIJIIJIIGIJHHJGGJJJIGDHGHIEHFEHADB@DDEEEDDDDDDDCCDDDBDDD<BB@
@0NR
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@@@DABDDAFHDAFBF??BFDC@E<:?FHFAG9?BEH9??FCBF?@D;AH?FBB8/)/5=@A@=@E=H;7A>AC>A>;?B3;66>@;;;555>8;;?@<?4
@0NS
GGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
@B?DFFFDDHDHHJJJJIGGIJJIGGHGGIIDGIIDGHJJJJJJJJJJE@FFCGIIGHIIIIIIEGIGEHHCHHFFFFFC?C@B?CBBCDDDDDDDDDCDD
@0NT
ACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTC
+
@CBDFFFFHHHHHIJJJJJJJJJJGIJJJJJIJGIIJHIJJJIJJIJIJIHHIJIIGGGIGGIHIIIJGGEEHHHFDCCCCCCDDDDDDDEFDDDDDDDDD
@0NU
TCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCT
+
@@@FDDFFFHDFHFGIIIIIJI?FCDFHGGIJGGIGFGEFGFDHFGGEBGGHGGCF>CFHIJBG;=CE@AHHHH@DD@DBA39=@BCCDCA@:@AB?BD@A
@0NV
CTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTT
+
BB@FFFFFHHHHHJJJGIIJJJIJJJJJJJIHGIGHGHHGDHHIJHJEIJIIJIJJHIJIJJJJJJJFIGJIGIJHHHHHHFFFFFEEEEEEDDDDDDDCD
@0NW
GAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCC
+
CCCFFFFDFHHHHIIIJIJJJJJJJJJJJIIJJJJIJJJJJIJJJJJIJJJJJJJFIHGIIIJJJIFGHIHHHF9ABB?CCCEDDDDDDDDDDDDDDDDDD
@0NX
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
??:BDDDA:DFF<DB<EG@FCGIG=F?EFGGGCEHIIHGIGGIGIECFHDHGGIGIGIGEBHGIIIFHAAAD?DECCCCCD@B@B2=BBBCC@CCC@CBB
@0NY
CTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTT
+
B@=DDFFFHHHHHJJJJJJJJIJJJGIJIIJJJJIJIJIIIIJJJJJJJJJIIIJJIJJIJIFHIGGIJJJIIJJIJJJJJHHGEHHFFFFFFEDEEEEEE
@0NZ
CCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAAT
+
CCCFFFFFHHHFHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIGIJJJHHIJJJJJJIIJIGIJIJJJJJHHHHHEFFFFFFDEEEEEDEDDDD
@0O0
CCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGG
+
CCCFFFFFHHHHGJJJJJJJIIJJJIJJJJJJJJJIIJJIIFGIJJJJJJJJGIJJJJJJIIJIJIJJIIGIJJGHJGHHHHHHFFDBDFFEEEEEEDDDD
@0O1
AGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGG
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJFGIIIJJIJJJJJJJJJIIJJHIJJJJJJJIJDBBDDEDDDDDDDEDDDDDDDDDDDDDDDDDDDDDD
@0O2
GATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTTTTGTTGAGGCCAGAATTCATGTTATTGCCCCAAGCT
+
@C@FFFFFHHHHHJJJIIIJIJIJIIJJJJJJJIJJJJJHIJIIIIJJJGIGIJJJJHHFDDCEDDDCBDBDDDDDDDDDDDDADCEEEEDCCDDDDDDDC
@0O3
CCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGGGCTGTGCGGGATAGGGGTTTTCCG
+
@@@FDDDDFFCFFGGBDGBHIGHGIFA@BD@7;B@CCDA@ACCB@DBBACDDDBBBBB?C>C:CCAB?BBBBBBDD???C@DDDDBBDDCCCBBDDDDCCB
@0O4
CATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGT
+
@@@FDDFFHHFHFGIBHGIIEIIGI<CEHIGIDEHGHCHIIIHII@GDHCAFGGGIIEHIHIBHGGEG1=FGHIAHDHHEHHHFFF>@@;;>A@DE@CC=
@0O5
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCAT
+
@@@ADBDFHHFDDEFB@C?CGH@HIADHIB@FHI?CFG@FD@DHIEEGAFDEHBBG>GI@CHIIDHIECHEB>';;??>;@>:>;A:>(:>,8?&::::@
@0O6
ATCAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGT
+
:;+4BDDDHDDHBHBHIICFFIIFEHG@HA?HFI@HCFEH@G@DC9<C?DDGH@FHI:3DHCFAHD)B=BFHFFCGG;=D@G7@EEH>??@>B??BCC@>
@0O7
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGG
+
??@D4A=:C>FDH@FHAFHFGHIGC?A@?@GB9<D??<CC9D@AF>D<FF>;DAGG@9A;A7=@@DD;>3>6@@CC@CCBBB(::A;:;@:A:A:ACD:?2
@0O8
TGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTG
+
@C@FFFFFHHHHHJJJJJIJJIJJJJHHJIIJJIIBHIIIIIJJJJHIJJIGIIIGIHHFFFBACEDDDDDBDDDDDDDDDDCCDD<BDCEDDDDDDDDDD
@0O9
GTTGAATTTGCTGATGATCAGGGCTTCCGTGAGGAAATCCAGTTCGGCCTGGTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTG
+
11:=42=BDDDDDADEED<AECAD+A3A)2?EDIII@?4**0:B4B)7@<C(8))8)=)8ACDCD37ACA?@?@=>?=AAAAAA???>A>A>>2995;3<>
@0OA
TCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCT
+
@@<DDFFBABCFBHHFGG>@IIHIIEI9BHHGHGIIDGEHIGIIGGEIGIHID>GGH@FFE?FHCHIGH>F>8=@ECDEEECCEFH>@?DB;;;@CEC;AC
@0OB
GTTCATCTTAACAACCCCACACTGCTTAAAGAAGTCTGCCAGATCATCTAGAGTCACACTGTCATTTAATCCTTGTACATAAATTGCACTGTTGTCAGAGT
+
?:=??D?=A>FCFEEB@@D:?BFBCFHG9:CF3CG>F9DFD>F3B@EGEHDF90//=8883==CGHIIC>AG@C:C;:A:?CEED;77;>>A@@C@@;5;;
@0OC
TTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGG
+
@@<DFFFAFHFHDGGCGGIGGGIHIIIIIGCF7?DGIIIGHF@?FGCBDHEHGGHI@FEHI>ECDGGGHECHABDFEDEECEDEACDDCDBDBB>DDDCC>
@0OD
CTAACAGCAATGTCTCTAGGTACAGAAGGCATAACACTATGCCACTCACCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTG
+
CCCFFFFFHHHHHJJJJJJJHIHJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIIJIGHHHFFFFFFFEEEEEEDDDDDDDDDEEDD
@0OE
CGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGC
+
@CCFFFFFHGHFHHGIJJJJIJJGHGIIGHIJJJIFGHHIFHJJJJJJJJJJIIJJJJHHHHHFFFFFEECEEEDDDDDDDDDDEDDCDDDDDDCDDDCDD
@0OF
TGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTC
+
CC@FFFFFHHGHHGGC2<AFHHIHIIJIJJHIJJJJIJJJGIIIIIIJJIHIJJJJJIJJGGIJJIJHHHHHHHFFFBDDDCD@CCCDCABCDAACCC>C
@0OG
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
?@1DDDEDFHFFGIJJJICFHGHHIJGHGIGIGHHGGHGIGHHGGHIHHGGGEHIG8@GAGGAEAECFFFEFDE>CE6=?BACCDDDCDDCCDDBDACDD:
@0OH
CTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTT
+
BB@DDDDFHHHHHJIIGHJIIIJHIFHIEGIFGHIIIIJJGJIJJIIIGIJJGHJJJJJJJGHHFFFDFFEEEEEDDDDEDEEDDDDDDDDDDDFDDDDDD
@0OI
CGCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCATGGTCCGGAAAATCCTCCAGACTCCTG
+
CCCFFFFFHHHGHJJIIIJJJJJJJJJJJJJJJIJIJJJJJIHIIJJJJJIJHHHFFFFFFCECDBDBBDDDDDEDDCDDDBDDDDDDDDDDCDDDDDDDC
@0OJ
CTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCC
+
CCCFFFFFHHHHHJJJGHIJIIHGJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJJJJHHHHHHFFFFFFEEEEEEEDD
@0OK
TGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGAAGTTGGAGTAGTATAACCAGTGGG
+
?@@BDDDAD<FF4CEA@@FB@<<BBHEIDGIHIGIC9CD>?FFE;DF;?BF9BFFG@FHFCH;D@HG=?EFHEC>&08@ACCA3(+:4@BCD>>CB:>>@
@0OL
TTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTC
+
@@<DDDA<::CFFBF;CF;+3<EF<?EFCFGFG@G?DE<D<B4BG@B*?F8988BFFE<FEE>77;):6?@;@(;>;@C;;AB@;@A@:>::>AAADEDB>
@0OM
CTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGT
+
@C@FDFFFHHHHHJJJJIJJJJIJJJJJJIJIJJJJJJHFFDDDDDDDDDDDFDFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0ON
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
??;DDDDB?B?AFHDD2@CAFH?EH<?9CGIE<@GFFHIIIDABBDGHGG?9DA;7;AEEEE@G<4AEEEBC;?>>CCCCBA>A@;@CCCC@>CC:ACCCC
@0OO
CAAATTCTGGAGTAAAGAAATGACAATCACATCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCCAGTTCCACAGAGAAGCCCTGCTCATG
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJHIJIJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFEEEDEDDDDDDD
@0OP
CTTTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTT
+
@B1BDFFFHHGGHJIJIIJJJJJJJJJIJIJJJGJJJJGGGHHJJJGIIIJJIJJDHGIJJJIJJIJIJJJJJHEEEHHFFFFFDEEEEEDDDDDDDDDDD
@0OQ
GTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGC
+
@@@DDEFFACFDHIIGGGEHIEHGGGIIIIIIIIGGGGBFBEDFEH?BFGIEHGGHHEDB)=FH;C@EG<EB8=?ADC:5<CCCC>ACCCCBCACBB@BC
@0OR
ATCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGC
+
?@?DBBDBF?D?DFHIIIIIIG>H@HHI@ADBEBEHGGBEGCGIIGI>CHHGFDBCAACC;>BCCC(>?<ACBCCC@CDCCC@C?B9<@BBBBCCCCCCCC
@0OS
CTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGC
+
@@@FBFDFBDHDFIGBE=CEFDFH@CGHHIGHBH?BDDD??BFHIIIIACADGHEGHEEE<D9;;>CCCCCC@CCACC?A@:@CCC>4>AACC>9AAC>B>
@0OT
GGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTAGAC
+
@@7ADDDDB?BBFIBHGGIIGIIHIGIIGCAHHGIIIIICGIFIIIIIIGIIIGIFHEHHHEEEECCCCBCCCCCCCCCCCDCCCECCDDCCBCBCCCCCC
@0OU
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJIHHHFFDDEEEEDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0OV
AGTGGGTGTGCGACCGAGCTCAGGGCCCAGGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCT
+
@@@DFFADCBFF>HJIJGEHGGGEIGGIJGDECAG;7CCEGEAEHEC@EHE@DFEFFFCCC>C@AAAACCDDB@BCDCAC9ACCCDDC@BBB<?CD@9>>B
@0OW
GAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTT
+
@@@DDDDDHDDDBEGHJIGIJHIGGIIGIGIEHIGHGEAGGIIIIJFHHHHDFFFFE>CECBD;BDDDDDCDDDBBD8??(48+:AC4::ACCDDDDDDDD
@0OX
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCT
+
@@<DDDFFFHHFFEGFIIJHGGIJIJJIIEGGGIJIIGDHEGH@DCCFHIGGIGIGIIBHFEEBDCFFCEEEEEDD;@B?CAC:ACBBBBDDDDDDCD@CD
@0OY
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
?8:AAD0AD?D<DEC<<C?FA<AF@EE?9DD;DDDEEDID@??/B@DACEBD;@@7@<==C=.=AD@@@77@>3.;A@AAA;A>A>>AA>A;??><2((05
@0OZ
GCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGC
+
CCCFFFFBFHHHHJIIJJJIJJJJJJJJIJJJJJJJJIJJFHIJJJHHHHHFFFFFFEEDDEDDDDDDDDDDDDDDDDDEED:@CDDEEEEEDDDDDDDDD
@0P0
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTC
+
@C@FFFFFHHFHHGHIIJJIJJGIIIGIJHHIIJJIIHIIIGIIIJ@FGE@FGHIGH=DHCEHFFBEACCCDDDDDDDDDCDDDDDCACDDDDDDCCD@CC
@0P1
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@@8D?ABBFFD?F>GAEFBBFFAC<FEFFIIIIEEEGFI:DE?GGFI7=CEFCFFAEIEEFFFCEDDDDDCCCCA@BBBBBB?BABBBB@?>AA>AAB?B
@0P2
CTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACC
+
CCCFFFFFHHHDHIJIJJJJJJDHIJJJJJJJJJJIJJJJIIJJJJJJJJJJJJJJJJJJJGJJIJJJJJJJFHHHFHFFECDEDEEDDDCFDDDEDDDD
@0P3
CTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATG
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJHIJGJJJJHHHHHHBEFFFFEEDDDDDDDCDDDBDD8ACDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDEE
@0P4
TGCCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCA
+
=?1=;??DHFHHDEGIIIIGHGCB3DBDFHII@GGHDGG@FFGH@8?;FGIACGADD=ECCEHFDFEFB;>CEEEA@@CC?55<>CCCC>ACC<ACC>?:
@0P5
GGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGG
+
@C@FFEFFFHHFHGJJJJJCGCCII?FHIGJGGGIIGGIEGGHGGGDFGEHCAEADEEFBA;AECCDDDC@C?BBD<><CDCACCDDDDACDCBCACCDC
@0P6
GGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACTGCTCTCCGT
+
@C@FFFFFHFHGHJJIJJJIIIGIJIJJJJJIJJJJGIJJIJJJIJJJIGGIEEHHGHIIJJ<EHFHFFBEFFCCDCEDBDBBDBDDDDDDDDDDCDDDB
@0P7
CTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTT
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJIJIHIJJJJIJJJJJJJJJJJJ>GIJJJJJJJJJIIIJIIIIJJJJJJJJJIJFHHHHHHFFFFFFEEEEE
@0P8
CATCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGG
+
@@8DDDBDD?ADAG@<EFH9FFA?AFEFGH9FAHBF?BFCFFDHHI<<@FEECG>>FBFGEGGGHCEA:ADEBBB@C>CCCC?C>B;>?B,58?A@CB>BB
@0P9
CTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTG
+
?@?DDDD;:ADDHAHEBFC@FDHGC?EHIGIIIIGHIIDIB:DFHAFFHGICGEG?HHFHDBDCCCAAACCCCCCCCCCCCCBCCCCCCCCADCAC>@ACC
@0PA
GCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCG
+
BBCFFFFFHHGHFHHJJJJJJJJJIIIIJIJJJJJJJJJJJIJHEFFDDEDDEEEDDDDDDDDDDBDDDDDDDDDDDDDDD>CCDEDDDDDDDDBDDDDDD
@0PB
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCT
+
?@@DFDDEFAFFDFHIIEEHBHHCEHCEGGHBHEEHGGIDHIF>FBGGHHFFDEDEECB?@DC?5:ADB98<>4>CDCCCDCDD?CD@BBDDCC@>@CCC
@0PC
GCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJJJJJJJJJIJJIJJJJJJJJJJJJJJJHHHHHHFFFFFFFEEEEEFED
@0PD
GTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCCCTGCCTCTTGACTGGCTTCAGGCAAGGAGGAGGCATCCTCAGTCCCCATGATAAGGAGATTGCC
+
@@@DDADDDHBCAECCDE@FHIFDCHHGIHFCHGHGGCD@FH<DHIGGCDGGDCHFIGEAGEHDE=:1A6;;>ACCCCCACCCBCCCCADCACC?A?CCCC
@0PE
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFFFGGGFBHIGIGEHHIGHGEGIJDDDDDCCDC?3?@CCCDDDDDDDDD?<BBBD?ACCCDDDDCCC@CCACDCDDDDDB@BCCCDCCDDD4>CB
@0PF
CTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTT
+
@@@DDD;BFHDFDGAAGA=ECG<CBFC>;CDHGGHF>FDGBDCH><FEDG>**0?BB/?@FHGCHG@A>F>EHGGGG3=E;37;?)7??@@C@;AC>CDCB
@0PG
TAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCGTTACACTGTGATTGATCAATATTCAAAT
+
CCCFFDDFHHHHHJJJIHIIJIJJJJIJJIJJJIJHHIHIGHJJJIJJJJIJFIIIIJJIJHGHDHBGGIIGIIIJIGJIIHIJIJ<3=AA;7;?7A;;76
@0PH
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJJJGHJIJJJJJJJJJJHHIJJJJJJJJJJJJJJJJJJIHIJJJJJHIHIHHHHHFFFFFFEE@EEDDDDD5?BDDDDDDDD@BD
@0PI
ATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGCGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
?::D+BAA2::;DE@C:;<AAA<AFFI4EE<<D?::?*:08DA0=.7.@.)77).)=C;),'9',,>AA>A(51555>;55+:(:AAA(+(++(+)++(:3
@0PJ
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@@?DDDDBADFHFCII?FHHIDHEIII@FBEGGIIIIGGEG9?GDDGICGIHIGBG:<=CGHICHG<:CE;?;AD;AACC@CC@>;A5@C?CCB?2>?BAC
@0PK
CCCCACATGGCTCCTGAAGAGCCTTCCCAGGGCACTGCTAAAGGCTCCTTCCCTTGAGGAAGCACTCCACGACCCCCTGTTTGTTGTCCTTTCTGCAATCC
+
@CCFFFFDFDFHFGGIIGHH?EFHIEHHGHJGFGFGIGGGGGIEHFGIIIGIIJJIFHGIB@DHHHHHHF?/>BDDDD<CDCCBCBDDCDDDDDDCDDCCC
@0PL
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGT
+
BCCFDFFFHHHHHJJJJJJHIIJJJJJJJJJJJJJJJIIIJJJJIJJJJHIJJJJJJIJJJJJJIJJJJJJJJIGEHHH7@CDEEDCDDEEDDDEEDDDDC
@0PM
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
CC@FFFFFHHHFHIJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJIJJJJJJJIJJJ=EHFFFFFEEEECEEEEDDDDCDDDDDDDD
@0PN
TTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTT
+
@@CDDFAFD>CCBFFFHEIGHFHG?FHHIEGIHCFFGHIIIIIIFCGIDGHHDFDGGGHFEHGHHAFFCCC.BCGAHE8@GGGIIDDEH=CEHHE9(.>;A
@0PO
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CCCFFFFFHHHHHJJHIJJJHJJJJJJJJJJJJJJJJJJIIJJJJJJJJIIJIJJJJJJJHGEHHFFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDD?BD
@0PP
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCG
+
@?@DDDDFHHHHHIIG<AAFHIGCFHGEHGHGCHGCGHICHGIGIIIIIFFFHFFGFEGIII@F@DHG@>=E>CDFFFDDCDDDDBD?BAB3@CCCD>C?
@0PQ
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFGHHGHJJJJJJJJJIJJJJJIJJJJIJJJJJJIJJJJJJJJJJJJJJGIJJJJJJJJJJHHHHHFFFFFFFDDD>BDD?CDDEDDCDDDDDDD
@0PR
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGGAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
@CCFDFBEFFFHHIEBEFGIHGIGIJJJIIJJHJGIJGGBFHFHGFHIGIGHIEB=EFGGHJ':?D=@ADCBB=?CDDDCCCDDDDCDDDDDDDC5<BDDD
@0PS
TTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGG
+
@@CDDDDDFHHFDHIDHIDFH<CCCCFCHC@B@FFDGG>DGI@D;8D.77BGECAGGGHIAAH>58?@CCC,9@C@5:>>@;;>ACCACCCCAABCA>>@C
@0PT
GTGCAGTGGCTGCTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTG
+
CCCFFFFFHHHHHJIJIJJJIJJJJJJHIJJJJJJJJFFHJIJJJJJJJJJIJHIJJJJJIIJJHHHHHHHFFFFFFEEEDDDDDDDDDDDEDDDDDDDDD
@0PU
CTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTT
+
CCCFFFFFHHHHFHIJJJJJJJAFHIJJIJJIJJFGHGIJJJJBGHIJJJJJJJIJJJJJIGJJJHHHFFFFFFEEEEEEEEDDDDDDDDDDEDEEEDDDD
@0PV
CTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGT
+
@@+BDDFFHHFDFHGGHI>IEHHHGEIIHIIIGGHI?FHDGGIIIIICGFHIIHGHIIHIIHCHHFFBCEECCCCCBACC?ABB@CABBCCCCCCCCCCC<
@0PW
ATTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCC
+
@@@DFDDDBHDHDCFGB@DHIGFGFEBE@DAGCFHEGEB@BDFDCCFDGGHHGEHDE;@;B;;?@CE>?CEDB3;=3>@@A@:8<<?@>@AC:A>@A:CCB
@0PX
CCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATG
+
CCCFFADDHFHBHHIIGDAHEEHHFGGIEIGDHGGGGIGGE@FHCCFHEGIIGDIFHHC?B<9>BCC:@ACBB<?>:>C>C>ACCCCDCCDDDCDDCDDA
@0PY
GTCCCGATGAACGAGCTTCATCTCGGCCAGATACTGCATCCCCTGTGAGATCTGCCAGGCAAATGAGATGAGGTCGCCCATGGTGAGGGCCCGCTCATCCG
+
CC@FFFFFHGGHDAHIJIHJIGHGHJJIGGGIIJJIIGHJEFIHIHIIJJIIGGIJHIIIHHFHHEFCEFDECCEDDDBBCCD:A@BDBDDDDDDDDDDDD
@0PZ
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
:;?AB?DDD?FHDEGIIJIIJIIIIACHDHGGIJGIGIEHDCDCHGHIJJIJCCHHIJI=F@@@EA@CEHGHFFFCECCEECB@CCB=@B:CC@CDC:>C
@0Q0
AAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCC
+
@C@FFFFFHHHGHJIJIJJIGHIIGIJIGGIJGGGGIIIIIJJIGIIIIHEGEEHFHFFFFFFEDEEDDDDDEEDDCDDDDCDDCDDCDCCBDDCDDCDD
@0Q1
TGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATC
+
@@<;DDDBA??@@)1<<<F?G<EBFG?FF<G??DGGFECFEFFEGIEIIIIFIEFC=CFFD9@E=7?EEDEDDB@@CCA>;;@@3>=955:ABBB>ADDEB
@0Q2
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGG
+
@@@DDFFFGFFHDDHIIIIGIJJCHGIGGIGHGGJIHJGCIIIJFIGGBBB@BDCCCAACC>@@CCDDDABCCDAA@BB?B?ACCDCDDDDDCDACDCCCD
@0Q3
TGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTA
+
CCCFFDDDHHHHHHHIIIJJJJJIJJJJJJJJJJJJJJJIJJJIJJIJJJJJJJEGEHHHHHHFFFFFEEEEEDCDBBDDDDDDDDDCCDCDBD5>BD<C
@0Q4
AGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGACACCAAAAGACCCTGAACTCCAGTC
+
<;8BDDDBDHFDB>BB@@:FGEGGC1?;CGGHGIIEEGIEEG?;F>C>AEB=EB;?A;BB1=6;>>CC?=ABCBBBB?B@BBBB>BC?89ACCCC@CCCA@
@0Q5
GTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCT
+
C@BFFFFFHHHHHIJIGIJJJJIJJIJHIIJIIIIJJJHIIIJJJJJJJEFHFEDEEDEDDDCDDDEED@CCDDDEEFEDDBDDBDDDDDDDEEEDDDDDD
@0Q6
CAAGTTTCAAAGGGGTTGCAGGAGACAGGCCCTGAGACCCATTCATCAGCTGTGTGTTCTGAATCTGCATCTCCTCAGCCTCAAACTCCATGAACCTTTCT
+
?@@DADDB?FHHAHICEE?AGD@8?DF@????FBDFHGDCABG>BFCGIGEACF8CCD@CCD;;CHHHFA;;;BBDCCC@@;>A@CCCCA>@CA@<<>CAC
@0Q7
GGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGC
+
@@<?DD>D>?:A<2CA<AF;:CC<AF?FEB0::67?DHCB=F>CFA5A@=D?E;;?=BEE;:6;66>ACC?5@@C:@:::@D>>C>C@C>@CCCD>>:>>3
@0Q8
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHHHHIJJJJIJJJJJGIJGDHGIIGIIJIJJJJJJIIJIJAHHJHFHFFFFDDDDDDDDDDCDDDDDDDCDDDDDDDAACDDDBCCDDCDDD
@0Q9
GGTCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
@?=DDDDBDHBFHBH>)@FBGEH>FB<?F?EEGEFGIGGGH>FHECCGCFHC;@DG@DGEHFFEE<BBCCA>CCCCBB'88)>C@C>ABBB?BCACCACC4
@0QA
CCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCG
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJ>GIJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJGHIJIJJGHHHGHFEEFFFDDDEDEDEDEDDDDDDDDDD
@0QB
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
@C@DFDDFHDHFHIIIGIJGIEGDHIEHIJIJJIICFHIIIIIIIHIIEHHJIJJGGIIJEHIJJ.@BEGEGEHHGCCDFCDFCEECEDDDDDDDDDD@@>
@0QC
CACATATTCACGAACCTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTA
+
=?1=DD?DHFDH?GIIIIGHIGGIIIIB@EGHIIGABF<?FGIIGCBBDHFGFHICBHIHFFFCEEEEDCC@6>@CCCCCCCECACDDDDCCAACDDCDC
@0QD
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
==?D;BDA=CBB??AFG>G<AA82@)@CGIEF<9DGIBFGIIB9DF>@F?<B<B<4BBF;CEF@F@CD;DE;:49B?6;.>3@BBBBABBB@AB(5><AB9
@0QE
GTCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAAT
+
B?+BDFFFHGHHHIIJJJIJJJIJJJJJJJJJJJJJJIJJIJJJJJJJJJJJJJJIJJJJIGIJIIJJJIIJJJJJIJIJJJEGHHHHHHHFFFFFDEEEE
@0QF
GCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCT
+
CCCFFFFFHHHHHJIJJJJJJJJJIJJJJJJIJIIJJJJJJJJJJIJIJJJJIJJIJIJJJJJJJJIJJJGJIIIJJJJJJIJJJHH=AHFFFFFFFEEEC
@0QG
CGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTAT
+
@@CDDDADADHGHIIIIIEGIEEGIHHHFIHHGEIIGGIIGI9BDFC<DEFBHGE6BGGG>@;@;D99=C>CEEC@CDEEFC@CABB:B55@>BDC@A:>C
@0QH
TGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGC
+
CCCFFFFFHHHHHJJJJJIJJJJJJIJJJIJGHIJIIIIIJIJJJJJJIJJJJJJJJIHJJJJJJJJAEE?DDACDDDDCDDDDDCCD:?B8@CDEEDDDD
@0QI
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJGHHHHFFFFFFFDDD9?BD@CDDEDDCDDDDDDD
@0QJ
CTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGG
+
?@1ADEFFHHHHHJJIJJJJJJGIJJIJIJJJIJIIJIIJJJJJJJJJJJFHIJIJJIJJJJJIIJJJIHJJIIJJIHGGHHFEFFFFEECEDDDDDDDDD
@0QK
CTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGT
+
C@CFFFFFHHHHHJIIJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJIIJJIJJJJJJJJJJJJJIJHHGHFFFFDDEEDDDDDDBCCDDDDDDEDCDDD
@0QL
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGG
+
?@?DABBDDFFHBFBFHGGIGEGFHIHEGIIIIIIIIAGBF<DHHIIEEGGGCHGIIGGHHFHFFFF?CCACCECCCCCBCC?>@CCCCCCCCCCCCCCCB
@0QM
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
@@<DBDDDHFHHFEBAACFHHGB:<FEGDGDHFBHGFIGHGGIIEGHGEFIIEIIDFHIFFGIEGGGHFFHFHEEBACC@CCCCCDC@@CAACCCCCCCC>
@0QN
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
@@CFDDEFHHHHHJJJJHIJIJGGIIJIFEIIIGIGIJIIIIJJIJIGGIHIJGIJIJJGDEHHFDDEECCCECDDB=?B@CDDDCABDBDBCDDDDDDDD
@0QO
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCT
+
CCCFFDDDHHHHHJJIIJJIDHGJJJJJJJJHJJJJJJJJJJHIJJIJIFHFHIIGIIGIIJJIIGGJJJHHHHHEDFFFDDDEDBDBDDCDDDCDDDDCD
@0QP
GTGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCC
+
@@@DDFFFHHGHGJBHHGGGEGHGEHHGGGFFDD);>@C;=ACDCDCFDDDCDBDDDDDDDBD@B4>@C??B>ACCACDDDDBCDDCD?DDACDDDECCBD
@0QQ
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
B@@DFEFFFHDHHJJJJJJJHIGIHIIJJIJCDHIJJJIIIIJJJJJJIJJJJJJJJIJJIIJJEHGEEDDE@CEECEDDDCDDDDDDDDDDDDDDCCDD
@0QR
CTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
B@@FFFFFHGHHHIJIJJJJJJJJJJJHHIIJHIJJGIIJJIJJJJJIJJJJJJJJJJJJFHGHHFFFFA@CECECDDBDD@DCCDDDDDDEDEDDDDD
@0QS
CTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTG
+
@CCDDD>DFHHBFHII>@DHIIIIIIIGIIIIIGIIIIDFHEGGBAEEEEFFFFBEEEEE>CCCCCCCCDDD>ACCCACDDCDDDDDB@BDDD?B<BB?B
@0QT
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@@@DDBDDBAFFDGG@:?<<<:<CG2CG@FEHD@FHA@@9:BF=*9@:BFBB>C=7==A(6?>>CB>CDDB<>A;;@C?=1,8@@:A>8CC?:>:>C>?B5
@0QU
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CC@DDDDDBHHHFIJJIHIIIJIHIJIJIIJJGGIIGIIHGIJGGIGHIGIHHIIDDEGG@HHEI@DEHHFHEFFFFFFDDD9=BD=CCDECDCCBBBD@D
@0QV
TTGAATTTACAAGAGACTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTT
+
;?;=BDDD?HHDH@??EGB@FBACHBEHHGHB>FCHII@FHIIIIGGIIGHIICHIIIEIIII@@HIIBF@@FGHIIGICDHHHGEHHHFHEE@;@;@>;;
@0QW
NACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAAAATGGACTTAAGCTATAGCT
+
#1=DDDFFDHHHGIHGIJIGHIGGIICHIJHHHGFFFFFEEEDCCFEDCDDDCCDCCABCCDDDDDDDDDDDDDDDDDDDDCDCC>@CCDDDDDDDDEEDC
@0QX
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
@@@DDFABFDHHDIIIIEGGGAECBHIIIGGIDIDDGHGIGHGDEHG=FHCDHGEGIGII@CGHGGA>EHEDFEDFFD?BCDD@;;;;?<)8@ACD:>CC
@0QY
CCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCAAAACTTTT
+
@@@DDFFDHHGHHHIJGGHEGGFHIIJIIIJIIJIIJJIIIGHEHIIGIJJGIGGGHIGIIJJGIIGGGIH?GGGIJIGIH?CHHFFFFDFEDDDCCDDD
@0QZ
ATCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCC
+
@CCFFFEFHHHGHJIIJIJJJJJHIJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJHHHFFFFFFEEDD;?D?CDDDDDDDDDDDDDDDDDDDDDDDD
@0R0
GCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACAC
+
@<1ADDDDHDBBH??CBGCHIGIIIFDGG?DEHBFDA@@8?DEDG:@AGEHIEEEE?A>@@;C?DC@C<CAD@CC>@@A@C5:?@A:CA:4?B?<<@BB
@0R1
TTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAA
+
@@CFFDDBDHHFFIIIFFHIGIFICGCHIJJEGFHEGHEAGHIIEFHDGGGIIGIJHHHCCHGGGJIGHGIIGCGGIJGJGEGEGHEAACHFHFE@DFCE
@0R2
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CC@FFFFFGHHGHJJJJJJJJJJJDFFHHIJIIJIIJJJJGIJIJGIJJIJIJJJGHFFFFFEEEDDEDDDDDDDCCEEEEDDDDDCDDDDDDDDDDBDDD
@0R3
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGCTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
@BBFFFDDHDHFFGIGGGGJIHHIIEGIJDIIGCFC*?CBGIGGEHGHHGEHDHIIIGGIJJIIJIHHFEEHH@DCDD>BC6>CE3>;@BDDDBDDDB@9@
@0R4
GTGCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAAT
+
=@+A:B3B8F=DF=G:3CBDABB33AA@>F?E1*:<1:?B09???93898@=?B(88BCE36=EE;@C>.))7)7;B3?)7>(6>AAA===2>:(:5:@A:
@0R5
CGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGG
+
C@@DDDDDHGFHDGIJIGIIJIJJIFGGHJJJIGGEHIIIJIIJIJEIJJEGGHGGIGGGEGHGEGGIG=GIFHEDBA@CEAEDDCDDDCDDD>?BBDB
@0R6
TGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAAACGCAGAGTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCTCCTCTT
+
8;1BD:BDBDFFF:A:AECE>EH@>F<AB9F@19EF>@DEFF<BFGE)09?((''8..=)=7@AECC):5=?83==((,8=??<23:@@>@BA>>:>:(4>
@0R7
GTCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTC
+
@@CFFFFFHHHHHJJHIJJJJJJIJJJJJJJJJJIJJJIIJJJJJJJJJJJJJIIIHIJIJJJJJJJIJJJJJJJIJIJJJIJJJJJGHHHHHFFFFFFEC
@0R8
TGAGGCGGAAGGCCTGGAGGACCCTCCTGGCTGACACCAACAGCCTTAGAGGGCAGAATGGTCTTCACATTAGATGCTGTCACAAATGGAGGTGCAGGACC
+
@@@FADFFHHHGFIADDGHGIIIIEEIGB=BFFGGCGIIGGECECDFDC?DC>ABBBCCCC:ACCCECCCCCCCCCCCCC>CCCCBACC:<B22>C@?8??
@0R9
GTAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTG
+
CCCFFFFFHHHHHHIJHIJJIGGIJJIIIGIJJGIJJJJJBGIIJJJJJIIIJJJIJIIIJIHHHHFFFFDDEEEDCDDDDDEDDDDDCCDDDDEDDDDCD
@0RA
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHIJJJIJIJJIGIGGEGIJJJJJIHGIIFGGIHJII;BGGGHJIIIJ;AHHHADFFFFFDEDDDDDBDDBBDDCDDDDDD@ACDDDDDD
@0RB
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
C@@DFFFFHHHHHJJJJJJJJJJJJJJJIIJJIGIJGIJJIJJJJIIHIIJJIFHIGAHHHHFHEEFFFDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDD
@0RC
CCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGGTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
11+4A?DA3<D>DEEEA>;E:006)?D*?D2(((()8)))/)>)'''-,7;..6;((6((,',;8(::((+3344<44>>:A<2(+>4434<>?>>93:AA
@0RD
CCGCCATGAGCTCCAGCAGGATGAACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCT
+
@??DBDD+ADFDHEGGIIIIIC>FH@F8DDF:@DFBGGHCCF@@BGEFEHEBE@CCA>;>;?B=BCCCCCD>@(++()829>>A@@@3>@:C::>CC@B?<
@0RE
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHGJJJJJIJJJJJJJJIJJJIJIJJJI?DHFHIJJJIIIGIIJHFFCHFHFDFFFDDDDDDDDDD@CCCCDDDDDDDDDEDEDCDDDDC
@0RF
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
@@@ADAA?FBFAAADEI=<<:FECFCBFBFHGHHFDADFHBGGG@FGDGEEECE>@H@@7@@DHC@CHHBDDEEEDC@CC;>@38;CCCA>@AA@CC4>C?
@0RG
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@@?DD8?DFDCFF:C3:BFEHEFDF<?<F?*?D?<FD?;FCCECCFFF=C6@=;AE37?3);?B6>>.63;((;>;@A3:@BAAB>>55>A3@:4?BA@92
@0RH
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGTTCTTGTTTGATGTC
+
@<@FFFFFGHHHHIGEIIIIIIJJIJJJJJJJIJIIJJJJJJIGGIIJIGIJBIJJID@EHHFCFDDFEDEE@BB@BBCDEDEDDDDCDDDCACCCDDCDC
@0RI
TCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGA
+
?@@=BDDDF+CFFFFF;:?A;EF7<C=AFEE*:C9CADBFGBF>B*?>DDFC='0;FFECFII@@.=.=CED>=;B3>A@A;A>BB3>=(:8::>(5<<2
@0RJ
CTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATT
+
CCCFFFFFHHHHHJJJJJJJJJEGIJJJJIJJJJJJJJJJIJJJJJJIIIJJJJHFFDDEEDDDCDDDEDDDCDDDDDDDEDEDDDDDDDDDDBDDDDDDD
@0RK
CTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGGGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCG
+
<@@=;DD8BABD??G;@;@EC@F9?GDH9?DGIB?>9;FHCAF(75;;CCE8).6>6;>5;=;59>A>;5>::5@A@D>C>4>AC>43?CCC?8<<<8<5
@0RL
GAACTATTTATGTACATTTCATTACACTGTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTT
+
@@BFFFFFHFHGHIJJJJJIIJJFHJIJJJIGIJIFIJJIJJJJIJJIJJJJIIFBFGEHIJJJJIJIIJGGHHGHJJIHIJIJJHHHFFFFFEEEEEDDD
@0RM
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
CCCFFFFFHHHHHJJGHIJJJJJJIJJJJJJJJJJIIJJJIJJJJJJJIJJJJJJJIHHIGJIJJJJHGGHHFFFFFEEEEEEDCCDDDDDDD9@D@BD<@
@0RN
CTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJIJJJJJJJJJJJIJGIJJJIJIIJIJJJJJIIGIJJJJJJJJJJGIHGHHIHHHHHHHFFFFFFFEEEEEFE
@0RO
GCCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGG
+
CCCFFFFFGHHHHJJJJJJJJJJJJJHIJJJJJIJJJJFHIJJJJJJIIJHIJJJHFEHEEFDFFFEDEDD?ACEDDDDDDDDDDDCCDDDDDDCDCDDDD
@0RP
CGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
@<<;D@D??DFHFHIGDH@EGA<FEFHIC@>E?FD><@F>G9;FCGEADHGC;8;CF8;@@?=:?DEDDACC;>CCCC>=='>5:A@@C(>A(8?ACA:A
@0RQ
CCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCC
+
@C@FFFFFHHFFDIHH@CFGHIIIIIFFHFGGHEIICGEFGFGHGGGGGHCAFFFCFHIIGGIEGEHHHFCB@&584::ABCCCBBCBCCC<@?>@C@CCC
@0RR
CCCCACCAACTGCAAAATCTGTTCCTGGCATTAAGCTCCTTCTTCCTTTGCAATTCGGTCTTTCTTCAGTGGTCCCATGAATGCTTTCTTCTCCTCCATGG
+
@@@A?DDDDFFA+<C4E@GH>HEHIEHIBCGICCCGICE?D?G?90BDGI@9/?D?FAFIACF:@CCAEIA@D>?A7=7;?B;BBA6>CC@5;>AB;(:,,
@0RS
GCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCCTCCCTATGCAGCCC
+
@@@DDFFFHGGFDGBGBDAF<6;C?=A?EBFEEDC@;@C6?CCCA(;@CCC<AA3>CCCC97&7@3>(:8?@+2<?ACCB?CBCCC(35?BACA@CD:@?<
@0RT
CTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGT
+
@@@DDDDDFAF?DFBAC?FGFHIGEHGHBHGDH<G<?D@D>HIFA@FDH=@3==C@H7@==AEEB?CBB@?:AA>>>C>CCCCCCC<8<CBCCCBBBBBB4
@0RU
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
@<@BDDDDHF4AFGII>EDIGCHHEGGGIEDHEGHIHIGIIIEGHFHAHHIIGHDHEIGIIGBHII@FG8=AH=C?B>CBEBCCA>CCCBBBCBBBBBB9>
@0RV
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATAT
+
@@@DDDDDFHHHFG>HG<GAEACHCFGGDGIFCEGEHIGICE>;B=FDBC?DGGFHHIBFGGHIIECHEEEEE@DE?@@;>6>;;@C=CCCCB:>>CCCAC
@0RW
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTAT
+
@@@FDDFFHHHHHIJEHIGJJJIIGJIIJJFGIJJJJJJJJJIJJJJI@FEBHIJJHFFEFFCEECEDCCCDDDDDDDBDDBCCDCDDCDDDDCDDDDDD
@0RX
TCAATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTTGCTGGGGTATGGCATATTTCCAAGAGAAAAGATTTCCCATAGCAGCACACC
+
8?1:+2=8C)CAD:AB+2AAC>B4C9:C*:?@<9):B**0*?**7(?DA>)).8);A44=3).73=;))7@@A@@6>(-5(,-5;:(:>((55(59<?((+
@0RY
GGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGTGGCTCCAGTCTCCCTCCTGTTTGCACATAGTTTAACACAT
+
@@@FDFFFHHHHGJJJJIGIIII@GHIGIJIIJIGGGHIIEIJJIIJJJIIIIJIIIJIIFCHHJGIFIIIHHHHFFFFFFEEEEEEDDDDEFEDDCCDDD
@0RZ
CATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCT
+
CCCFFFDFHGHHHIIJJJJIJJJJJJJJJJIJJJIJ@GHDGIJEGIJJJJIIJJJIJBGIFIJJJJJHCBBBDEDDDDCCCDDDDDDDDDDDDDDDDDDDD
@0S0
GCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGT
+
CCCFFFFFHHGFHIJIJIJGIJIJJIEHIIJIJJJJJJJHGIJJIGIJJJJIIJJJDHIEGIIJJJEHIJHHHGHHHDFFFDEDDDDDD9BDDEDDDDDDD
@0S1
TGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGG
+
8;?D4=ADFF???FG<AEC<FHIIDEFGGAE3D?D<BFH6DGH8/7.7(44-4-;=C3?(.3(9??B@>???CC?B@@C?<:@A@>>>3(8>??838@?B&
@0S2
CTACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTC
+
CCCFFFFFHHHHHJIJJJJJJIJJJJJIJJJJJIJJJJIIJJIJDIJIJGIJIJIIJJFGHJIJIJJJJIJIJHHHHHHFFFFFFFDEEEEDDDDDDDDDD
@0S3
GTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGA
+
@@BFDDDDHHHHHGIIJJJJJJJJIJII@HEHGIEGHGGGDGCHJJJJBFHGHGIGID@FGE@CGHIBGGHHEAHEHDFFDDFC>CCDDDDBDCD@DC@B
@0S4
GTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTT
+
@@@FFFFFHHHGHIIJIGHIDHIJHFFJHEHIGIIIFGGIJJJJJGICGGEHGDGHIIJIGHGHHFJHEIGGIIJIIEHGGEGIJIFHGFFHHFFF@CEFE
@0S5
CCCAAAGGCTCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCTTGCCAGCAAAGCAGTAGT
+
@@@DFABDHFHHDHHIBGIEDBBEEEG0:CFHEIG8B?FGHIGGIE8-;;BD@ACCDDCDDDD@(:>@CC>@CCDBD<<&++:>4>CCAB?CCDC><CDD@
@0S6
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCGCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGAC
+
?8=D;;;;A3+::CE312A:<:??9CB@FF608?19*0?9?B<@?F3)88AFICC7=7C;AC3)?=EB@@3.>3;(>>3;;A>>/5<:???553&8298(+
@0S7
GTTCCATAGCTTTGTTGCCCATATGCCTGGGAGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCT
+
???B+BDD<:4<A92AE4ADCC3<A4?F+C?+)11?D39?9*?*0:BB9DD</*(?@C;A;24',,'-;>A>5,(,>>>:>95(>:(55-05((++:>7A>
@0S8
TTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCA
+
C@@FFFFDFFHHHJIGGIIIJIIJGIJJJGIIIJJIJJJIJJIJJJJJIGHGHIIIJJIIIJIJJGIIIIJJIJJFHGJIIIEHHHFFEFFFDEEEEDDD
@0S9
GTCTTCCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACAC
+
CC@FDDDAHFHGDGIGIJIGHHGIJIIJIJJJIIIGIIIGIGHHIIGJDB9BFHIJJHIJGHGFHIGIGGGGGHICCHHHEHFFDDFCCEEECEDEEEEED
@0SA
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGGGTAGT
+
@@CFADFDHAHHHEGIIIIICBHIII@HDHDFH<DBBAGGGHGHED8=FEGHGGIE@>CHCCHFHDEDDED@AA;CCDCDBDDD?>3ACDCCCCC&55<@4
@0SB
CTCTGAAGTCCTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACC
+
@?@DDDFFHHHHGGFHIJJJJJJJJGIGCHGIJJIGGIIIIIFGIIIJGJJIIIJEHIHHHEHFDDDFEDEEAEEDDDDDDDDDDDDEEDCDDCDDDCDDD
@0SC
AGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGGGGTGGGATCATAAGCACCAGTGCC
+
?@@A?DDDBFFDF@F?<@EEHCD@DHGG@GEEGAG<FEDD4DEH9BDEAGIEDDHIC.;B';A-5;;;;.7?;;C(9?'8:&2(8834:@3:9??@(:4>
@0SD
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTC
+
@@@DDFFFGHHHHJEHIHIGJJIIJIIJIGIJIIDGIJJIJGIGJJJIHIHGGIIJEGHIHEHFEFDFEEEEC@DDBBADCCCDDCBDDCDC:>?CCCCDD
@0SE
GGAAGAGTTTGGTAAGACACGTAGAACACAAGTCACCTAACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGG
+
CCCFFFFDHHHGFGHIIGHHJCFEHIGGGIJJGEIJJJJJGGIHHHIEIIIIJIHHHIIJIEHHCHHFBDDECDEDCDCCDC??<CBCCDD@@BDDDDDDD
@0SF
TGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGC
+
?@@DD?DDDA>FFAF<F>BDA<EFH?F?GH1?@F@BF9DHGC=C8B@HHGI@?>)=?BCB;3;>3>A>>>AACC>@AA@3>ACCCCCCACC@C:+4>>@@C
@0SG
CGGGGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGC
+
@@@FDFFFHHAFHDHHGIJJGJIGHIIIBG0?FHIJIJIGJJJIJJJHGFHBBEFFDECACCCDCCDDCDCDDDDDACCACDDCCCCCCA>CCDEDCCCAC
@0SH
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
CCCFFFFFHHHHHJJJJJJIJJJJJCGHJIIJJJJJGHIJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDEDDDDDDDDDDDDEDDDDDDDDDDB
@0SI
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@CFFFDFHFHHHGJIJGHIGJFIIJJJJJJJGDGIIIJGIIJGIGHGEGHHIHJJIJFHHHHFFF9;@>CCDDDDBDDDDDDDDDDDDDCDDDDDBDBBD
@0SJ
GCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTC
+
@@@DDBDBB?>DD?:EACEHEHGHEEH@F4F<F<EECFHGGHIIDCGFH0?86?BFBGE<CA;CBDHIGC@E>AHHED@?DDCCB=9@ADD>@@:>C>CCC
@0SK
CGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCT
+
CCCFFFFFHHHHHJGJJJJJGIJIJJIJJJJJJJJJIIHIIJJJJGJIFHIJIIJIIJFHHIJJJ5@DDACDDEDDCCDDBDDDDDDDDDDBDDDDDDDCD
@0SL
TTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTT
+
@@@DDFAAFFH?FEDHDGIIIIIGFICHCCGGHHIGIIDG@EHEDHGIGIEGHHIIGIEHGIE<?D@B;BGC=CCGFE==@ECE@EECE>>;BDDAC>C@@
@0SM
CTGCTCCTTTTGCTTTCTTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAA
+
;??DD8A+2CDBDBEEI@@A4A3:AE<CEFI>ED?*:94?C??:*9??4BDA@<??99/999?.=8=3=C>=@==)7=ACDC@D;A@;>A;;>AAA>A>A
@0SN
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CC@FFFDDHHHHHJJIIFFHGIIJJJIIJJFCFHHIJJJIIJGIJJIJJJGGIIDHIJJJCEEHHHHHEFEDFFFEDACCDACDD<CBBCDDDCBD<AC
@0SO
GCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTG
+
@@@DD>DDD;D:DAEACGHGIIIGGIEIIGIEHG?BDHH>BHEHHIBDHIIFEHDEIAAAAEAA==CEHEEDDECCC@C95@C@CCB?5?@BCCCBCBBBB
@0SP
CCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGA
+
@@@FADEFGDFFHGBGHIIJIJGGIIHFHEIEHIHIIJGGEGHGECDDBB8@BDDDDED?CDCD?DBB@;B@DDBBBBDBD<<><@@ABDDDBDDDDCBB
@0SQ
TTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCGCTTCTGAGTCATATGCAAA
+
;1?:DDD?DFBFFBF@EF>?AH:C<FH+<3?8*):19:?D3BGFDFE@@F<D>@FF@==CCAF:CD:CC6;??A?3;7@D'39>8;((5:,:AB5;35:@
@0SR
TGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTC
+
@C@FFDFDHFHHHFGIJGGIJJIJIHHIIJGGIIGHGBEIIHH@BFHJJHEFICGIIIIIGIDHJJJIJJIIJJJIIJJIIJJIGGHHHHHHFDFFFFEFD
@0SS
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
@@?DDDD;D?CFFDDHGHDGG<AB<9CCDFFEDFDHI9B?DFGEC<C<F7@AG7=@4))===3==);>;;>BAC@BCCCC>AA>ACCCDCCCCCCC4<<:A
@0ST
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
=@?DDD?@@?DFHHI@<AEHIIIIIIGEGGGCDDFHGIHD?GHIGHEIIEGGGGEEF8;@=7.@;A>?C>CEBCDCC6>@B;>@B55,<CC@BC?B??C
@0SU
CTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGT
+
@@@DDD>:=CCF?CDFEF>32AGFAGEECD3C>DFBD))8D>D3(<B4BFF@F=@@EECECEFFEFD>?@BBCCB@:??@BA(:>>AA3>5(80<9<B<?2
@0SV
AACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTA
+
@@@DFFFFHHHHHGIJJJJJIJJJJJJJJIIJHIIIIIJJJJIIIJIJJIJJJJJJJJFIIJIJJHIJJGIGHIIIGIJJHHFHHHHFFFDEEEEDDDDD
@0SW
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGC
+
??8AAD?AFADDC?FFFAFAF1CF?BDE>;?<B9B@??F?8B*/=F8BFA3@F?7;==;CF=;7=BD>D?;A@=.;5>;3->A>5:::A;>>A5AAAB?B@
@0SX
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@CFDFADHGHHHJJJJIHJJIJJJJJJJJIJIJIJIJJIIIJJFJJIIJGIJIIJJJGGHHHFFF9@B8CCDDDDDDDDDDDDDCDDDDDDDDDDBDDDC
@0SY
CTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGC
+
C@CFFFFFHGFFHIJJJJJJIIJJJGGGJJIJIIIEHJIJIIGIJEGIGGIIJJIJICHIIGIIIHHHHEFFBCDACCEEEDDDDBDDDDDCCDDDDDCC
@0SZ
CTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATT
+
;<@DAD?DFDDFDIIE94,@A<9CHF@FF@BFEAD9D<*??:?DDE;BDFDDDC>B>FE;))/@E7CA4)7A3)999=@/;/5-<@@3>::BD>>:>>>>@
@0T0
GCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHHHHJJJJIJJJJJJIJJIJIJJJJJIJJIIIIGHIJJIGIJJJCFFHGJJJJJJJJJHHHFHGGHHFFEFFFEEEEEEDCDDDDDDAC>
@0T1
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
??@F?ADD<FDDB@AAHHFC>EHIEGGIBHEH@?@GDD99DF>D<D<D?@HG8CGHGCB>FC;@EGEF6AA@:7?@;>>>@A7>?',;>0>9CA>@448?
@0T2
TGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTC
+
CCBFFFFFHHHHHJJJJJJJJIJJHIJJJJCGHJJJHIJJHHHHHFFFDDDDDDDDDDDDCEEDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDD
@0T3
GTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTG
+
@@<ADDEDFH?HAGGGHGIIIIIIIBE:CGHBFGDH>GAF@GHGHGGCCHBHHGHIEHFBBBB@CCCDD9ACDDDDCDC?B?ABCDCDDDDDDDDDDD0<>
@0T4
CTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAAC
+
B@@FDFFFHHFHGIJIIJIIJGIJHIJGIJHCHIIIGIJJIIJJGHGHGIJGIHGGGFEIJJGIJIGGAAEHHFFEFFDC@CAEDDEDDDDDDCECDDDDC
@0T5
GTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTG
+
@@@FBDFD@CFFHEIGGGHGGGGGC<DGGHEIIIIEGIGGEG@GGIEGIIGIEEHHHGDFFCFFEECC@CCDEDDACCDCC<??@BDCDCCCDCCCABDED
@0T6
GGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGC
+
CCCFFFFFHHHHHJJJJJJJJJJIJGGIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFECEEDEEDDDDDDDDDDCDDDDDDDDDDDDDDDDDD
@0T7
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
@@CDFFFFHGHHHJJIJJJJJJJIJJIJIIIJJIIJJJJJJIIHIJJJJJIIJJJIIJHHHHHHFFFDDCEEEDDDDD@BDBDDDDCDBD@DDDDDCDDDD
@0T8
CACGCCATCAGCTCTCGTGAGTGGTACAGGACTCTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTC
+
@@@ADDDDH?AF?:EAE<F;A<<CA<<:C9FBGFEBD9??DF=BB?FD?BA068=;@@=@C>?CCC>;?7@CCA@CA>>CCCC:@@DCC5>C?85999528
@0T9
GCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATT
+
+1=+?D:B2CBBBFB<C<<<3CBA@EG?::1))6@FFFIFEC=FA)88=CCDA=A=.=A;E;;@BB>BC3;@@:??B6((5>35<8<8>AA444:3:>4>A
@0TA
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
?@@FF>BBDFFD<:AGBFEIGCCFHIHIGFGEBBGHGHDFGFFHGGHGEHED?B<BF@CCCG@@FGGCCDGGA7=>5??;@CEEDCCC>A@C>C5:?BBCB
@0TB
CAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGC
+
BCCDFFFFHGHHHJJJJJHHIJJJJJJJJJJJIJIJJIJJJJJJJJJJBGHHIIJIJJJJJJJJJJJJIGHHFHHFFFDDD@@BDEDDDDDDDEDDDDDDD
@0TC
TCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTAT
+
@@@DBBBDC<DFDFEHGHHIIHHCCG?F@GGIIIIBDGGCFBGGHC<BDHH?BFDHFBHICAFEHIICHEHG<CFDDCEAD7=@EE>CHFFEEEECCCCCC
@0TD
AGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGATAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCGTATGCCGT
+
@@@FD=BDHHHFFHGBFEHHIIGEHIJGGCHIGGFHHIDCFDHCGHIJJIFHGCHECFGG=C=CGHIIEDEEFBD@D@:A@DEEED>A>;>@B?<?CCC?8
@0TE
GGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGAC
+
CCCFFFFFFHGHFIJJJJFIEHEHGGGHIJJJIJJIJHI)BD78@FHIIJEHGIIHHGGGGFFEDAACCDCDDDDCDDCDDDCDCDDCEEDCDDDDDDDCD
@0TF
TCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTT
+
B@BDFFFFHHHFHIJJJJJIJJIJIJJJEGHIJJJIJJJJIIJJJJJJIIHIJJIIIJJGHHIJGGGIJJHHHHGFFFFFFAEEFEEDDDDDDD:ADDD
@0TG
TGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTG
+
@@@FFFFFDHHHFGJIFEFHHGHIJJIIHGGHIGIJJFGGGGGGGGHGIIJGHJJIGIJJDIIIBHCHIHGHFFFEBA@B>CDDDDDBDDCCDDDCCDED
@0TH
CTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTT
+
@@<FADDDBFFHHIIIJJJJIEHIJIJEHIHCHHI@@CGGIJJJIIGEHFE@FFDHIJJJIIIIJE;DGHGGHEEE@BEFFFB?CCDDBDCC?CD??CCCA
@0TI
CCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTG
+
CCCFFFDEHHGGHJJIJJJJJJJIIJIIIIJJJJJJJJIJEHJJIJHHGHJJJIJJFGHHHHGFFFFFE@ACEEEDBABBDDDDDD<CCC>ACDDDDDDDD
@0TJ
GTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGG
+
@@@FFDFDHFHFFIIIEHIFFHGJIJJIJIIIIJHHGIIJJJIJJIIJCGHGIIFGJIIIHHGIFIIJHHHFDBBDDDDDACCCCCCDDDDDCBACCDBBD
@0TK
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@C@FFDFFHGHHHIIEGGGHIFGGHJJGHHIIGIGHIJJJFIGIIIGGGGEGIIGGIGIJJJJIHJJHEHFFFFFFEECEDEDDDCABB?BDDDCDCDDCC
@0TL
CGTGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCCTT
+
@@+=BADFDHHFHJJJJIJJJJJGGHIGIIJEHIGIIIJJJJJIJJJJJJJJGGIIIGIEHEHHFFHFFFDDEDDDDDDDDDD?CDDAACBCDDDD@DDDD
@0TM
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFFF;DHHHHHJJJJIJGFHEIIIIJJJGFGDFGGIJIIHIIJGHGHIGJIIICEFHEHIBHHDDFDBDFEECCE>@B;@CCEEDDDDDDDDBCCCDDC
@0TN
GCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGG
+
CCCFFFFFHHHHHJJJJJJJJHIHIJJJJJIJJIIJJJJJJJJJJJJJJJJJJJJJJJI?EHHHFFFFDDDDDDDDDDCDDDDD@CCDDDDDDDDDDDDDD
@0TO
CTCAATTAGAACAGCTCCAAGAAGAAACATTCAGACTAGAAGCAGCCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTC
+
@;<;7?DD?D>FDHGE>AC3<<ACFCF>FGC?<9EFG?9CFFG@EGHG@B?9?BFHA<88=B)@()67=((5?77)(7;7;?7>C;;9;5;@@ADCC@3>C
@0TP
GTCCATCTCAAAAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACT
+
@@@DFFFFHGHHHJIJIJJIJJGJJIJIJIJJJJIJJJJIIGIIIGIHHFGDDDDDDDCDDCBBCDADDEEEEDDEEEDBBDDDCD@CCCDDDDDBCDDDC
@0TQ
CGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTG
+
@C@FFFFFDHHHHJJJJJJIJJJIJJEIIIJJFGGIIIJJJIGIIJI?FHIJGIGGIIHIEHGHGIJJJI=DEHHFBCCCCEEDEDDDDDDDDDC:A:CAA
@0TR
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTGTCATCAAAGGG
+
???D;=B;D><4AC+A>EEE@4CCB:C2<81*?E9?9??::DADD)?;65A''3;(;.,;55;;????(5;90;>>DAAAA<9:>A(+((::(:>:(2
@0TS
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@@@DD4BDH8D>FG@FHAABDHFC3FACEHG@FGGII:@G3B@DBE><9D@FG;8C@FCEH;D;7=D@:CE;;?<(;;@CD:@?C@;?B=?BCC>>AC::A
@0TT
CCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTT
+
@@@DDDDBFFBFHGGGEAC3AFGHCAHHHEFFH>FGGGDDCCBCH<DAGHCGIBFA?FEDC>@FFGHIGIHFGI>CGHGIAHFCHEB>=>A;?CD<@CCDC
@0TU
GCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCCTTTAGCACAGTGATTT
+
@@@DD8;DF?B<C?E>DBHG@@BCFAHEH?:CCFGIIIADFDAFCG999?9DD4CFG;C@AADHHH7.6;@BDCE;;ACCC?>@B;@CC:A>:9<C@:::>
@0TV
GTCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGGGATTTGGGCTGCGTGCAGACGACGGG
+
CCCFFFDFHHHFHIJJJGHHIJJIJHIJGHGIIJJIJIJIJJJJJJJIJJEFHJJGIJJIHHHFFDDDEDADDDDD?BDDDDDDDDDD@BDDDDDDDDDDD
@0TW
CGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCACCAGGATGGAAAAGCCTGTGTACAGGGCTCCGCGGCTGCAC
+
@@<DDDDDF?CDD<2AAA?A<C;EDGGGEH:@:80(8?DBFCG@GGH@==8?;ACC<5>>C@;;?B::<>C>99?BA8+>(4>@>3?0(28>BB@<3503@
@0TX
TGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGT
+
@@1DB?DFGHGHFGIHHIIIID@GGIIDBBB8@CD@C>CCA>CDDCCCA39AD<?8BBBBCDDCDDCDCCCDDDDEDCDDDD0<9?ACD@CCCD4>C?:@>
@0TY
TCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACT
+
@@@DDD?A=CB?FGBAFHBDEE>3A?GCHGE?C;9:9?:??GF?FG9BGH:8?D;4BFHI.8/8@G>@;=C:=77=?>;B)77;;>@656?5AC>;>>::5
@0TZ
TAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCA
+
<??BDD4:DDDD?A4AEE>E@ECA)+22+9?CEDDDDDDDDD>DDDE<886(;=@@;@C7=@DE>AC)?A?@?;)7.;;@66@AA?;;;>ADD>(,2:((
@0U0
GGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTT
+
@C@DFFFFHHGGHEGGIIIJCGGCHGHIIJJJJIIIIIIJGEEGIJGIIJGHGDGHGHIGGJJIIIJIJIJIJJEHHHFEEDE;AC;@CCCDDCDCCDEED
@0U1
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGTTGT
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJEGIGHIJJIJJIJJJJJIJJJJJJJJJJHHHFFFEEECEEDDDDDDDDCDDDEDFDCDDDDDCDDDDDD(8?>
@0U2
GGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGT
+
??=BA??=AFCFDDGFD=?GGIIGIDDCFGD???BGI@@F6=FFHF=@C3CDDHIGIHFAAECHD;?@;CA@66;6@CCCCBB>?C@CACC::ACCCCC?9
@0U3
CCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAAT
+
@CCFFFFFHHHHHIJJIIIJJIJJJJJJJJIJJJJJIJJJIIIIIIJJJIIIIJEGDHGGIIJGIJJIIEGCGIEIHHGGEBDCCCDDCDDDDCDDCCDDD
@0U4
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
CCCFFFFFGHHHHGFGIIGGIHGHCHIIIIEHGGCGHIGHIIGIGG?CEGDFFGGIJHIHHF?E@@DD<?C;A@CDDBB8;?CCDDDDCDDCCDDCB@DD9
@0U5
CTCGGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJJIJJJJJIJJIJJIJJIJJIIJHHHHHHFFFFFFEEEEEEE
@0U6
ATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGT
+
?<1A=AD3A:A?75:8A88>=((+88>B8>AA<>33(2+)2<=?<A>>>399>A>3(:>AAA3>?>>?>>A>2>AA::4:(+4::>A(:><3(+9A<8<+
@0U7
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
@@?DDBDFFGFGHFGIGIGGIEHHIHIIIGIIIIFHGHIGIGIIIIIIDGIHIIIIIIIIIIIGHIIIIIIIHEFFDCC>CCCDDDDADCDDDC9@CDCCD
@0U8
GCCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGC
+
CC@FFFFFHHHHHJJJIJIIJJJJJJJIJJJJJIJJJJJJJJJJDHIJJJJIJJFJJJFHGGIJJIJIJJJHHHHHHFFFDDCCCDDDDCDDDDDDDDDDD
@0U9
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
CCCFFFDEHHHHHJJJJIJJHIJJJJJJJJJIJJJJJIJJJJJIJIJJJHIFIIGIJJJJJJJJJJ=EHIEHHF5@BDCEEDDDD<ACDDDCDDDDDDDDD
@0UA
CTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCT
+
CCCFFFFFHHHHHIJJJJJJIJJJJJJJJJJJJIJJJF?FHIIJIEIIDHHGHIJIJJJHHHFBDEEDCEDDDDDCDCDD?ACDEDDDDDDBDCDDEDEDD
@0UB
CCTCCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCAGG
+
?@+=ADDDFFBFFGIIBGEGGECHIIBCBFCBHIIIDDHGEFEGGIEGHIFGIHIIGEIEGIIGGGGEEHHDFFFCEECCCBBAABCCCCCCCA??ABCBB
@0UC
CTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTC
+
@CCFFFFDHHFFHIJJJJJJJJJIJJJEHJJJJJIIIJJJJJJJJJIJJJJJJJJJJJJIJJJJIJJJHHHFFFFECCEEDDDDDCDDDDDDDDFDDDDDD
@0UD
CTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTC
+
?@?AD?=AADFHA?AECGICDD;?8AE@FD@DBHC<C??:D>?BF49D?999/0/98;/8B=;;C;=65CEHH;==777;7;6.;>65=?=5>CCCD:/,5
@0UE
GATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTAT
+
=??D?DADFF;BCFGDGHGIEGIAFHHIIHIIIGGIIIIIICGGIGGIIIED>CHCHHCEIHIHFECECADEEEDCCCC?C@AA@CCCBCBACCCCC@CC@
@0UF
GGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
@@?DD?FFHGHHHGGGGHIGJJCEBBAEHGBHIIGGHGIIGGHEEDDHIIIEGGIIBBHEEFFEFDBEDC@C?@C;AC@CAC@>A??BDD9>CDCCCCCD
@0UG
CCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAA
+
B@BDDDFFFHHHHIFGHGDIJJJCHFHGGHJCFIGGGIGIIDGIHIIHHGIIEGHJJJIDD5<DDDCC@BDDBDDB:C?CBBDDC>CCCDCDDDDDDDDD
@0UH
ATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCG
+
@@CDDFFFHFHFHJIIIIIIIJJJJIIAHIIJJIIJJBGHGHCHGGHIIHGDCCHIJGGJJEHGEG@DCCEHFHHFFFFEEDDBDD?5:A=>>B>@A?BB>
@0UI
CGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTT
+
??@DDDDFDD?HFHGII@HGIIIGIIEHIIGIGIIIIGIIHIIHGIIGIIIGGIIIIIIGHGIIIIIGFAEDB@ECBCEDDDDDB?:@>CCDACDC@CDCB
@0UJ
TTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATC
+
@@@FFFFFHGHHHIHGIJJJJJIIJJIJJGIJIJDHIGGIGGIIIJIJJJJIJJJGHGHIJJJDDGEHIIGGIIIJJIIJGGGHGEHHHHHHEEFFFFDEE
@0UK
GTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGG
+
?::DADDDDHFFHIG@GBECAH>CEEHGFGGI@@CDG@FHBDD<DDGHCFGBHCGH=CEG@CF;CGI>A@7@GHHEEHHDB@CEC>CACCBB@CCAAC@C9
@0UL
GATGNAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGT
+
=8:B#22A?FFH?E:EAGEGIIIIIICHGGGIIIIGFGFEG@C@EHHAGEGHHHEEEEE@D?@CAAC>CACCCCCCCBB@@BBCCB?B9>9?CC<CA8:@<
@0UM
CGTCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGT
+
?@+=BDFFHHFHDGGIIIIHIIIIIII?EGGEHGIIIIIIIIIIHFDDDDDD>CDCCCCDDCAB28<CDCDDDDCCDC>@CCCDCDA<@BABBDDDD.<B2
@0UN
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
@@@DDADAFD?FFBEDFEBBHGHIHCEECCCFDDHFGB:DGFFIBHGIGGGCCGHFHDGEEADDF5@;>;@@3;ABDBBD>:>CC>ACC:A?B8ABB@BD
@0UO
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGGGCAGTGACTGGCTGCATGGGGTAGCTC
+
@?@D?DBD2=DAFFCBBAEEEHFHEFBHFE?EG::?D?G4?D?DF?B<B?*8BF)8BC)=BE5;;A)7==??B'333;(555(:?9(88>:A@B@&08>@>
@0UP
CTGGTGTGGCAATGGGGCCAATCTTTTCTCTAATCTGCTTCTTGAGCTCCTCGGTGAGCTTGGGGCTGAAGGTGTGGCCATCACACAAGGTGACAAAGC
+
???BD+2AACD?AAE;AE8FBFFAEE??:?DBDB??<4????DE4DBD>DC;?'<;-@DCC=C=DD/?;76>.6(;5;?AA>A>A:88=<(:A>449>9
@0UQ
CCCGCCTTCTCCTTGGGGGTCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGT
+
=?8=?DDAFF4CCBFFGIFABFEICEFFGFGEFICADFC9D@FFFFA.8.77@48==4?>@@>>6;;>AB:@55<?B??ABBDABBB>>ABBAABB::BDD
@0UR
GCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJIJJJJJJIJJJJIIJJJJJJJJHIJJFHIIIJJJJIIJJHHHHHHGDEDDFDEEEEEEDDDDCDDDDDD@C
@0US
GTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATC
+
C@CFFDDFHDHHFBHGGHJEFHJGIEAEHHHHHIDEFIDHIIJA@BD@GIIJEGIIGIDDFEGHIIJJIIJIJIJGIIIGJGCEGHE>?CHHFEF;?CCC@
@0UT
CGTGTCCATTAATTTTGCCGCTGAGGGGGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGGAAACCCAGTGTTAGTGCCATCAGCTCTCG
+
::1A===:ADD4A<EEBEA:333<A@?))???;DB<DBEEBD)...=C@@=)..=@7ACC:=377@3?;(;A;;>>=?7;5>55:3:>(55>:AA>>3>40
@0UU
GATCGGAAGAGCACACGTCTGAACTCCAGTCACGTGAAACGATCTCGTATGCCGTCTTCTGCTTGAAAAAAAAGACCATATGCCTGGGTGGTCTGTGCAT
+
;?1ABD1AC:CB?<2<?<32<<AFEA91?::D1?DDIDE<6@8/0*87(..@CAD@65.==CCD;6;76(,','(+++4>ADA:>A>>(00)+:<4:>AA
@0UV
TGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCAT
+
@<<=B?@DFFHDFIBGEGGCDB@FCGGE@FDGID@D;F>GHGGG@D?FHHGHIIEHIIIGIG@BH::BDD7?AECEECC;>>?A8?AAA@DDBCCCB?CD
@0UW
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
11144222=?DDAF<CEGHE?D@>FE9B=;@C@'5(=A'49AA@>3;CCC9,,:555:(;@3>>A>CA:>>A>>?8?(29?@((:>>CC<ABAB98:(:+
@0UX
GTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCAT
+
@@@;BADDDDFHFEIGIIAFDEC>CHHGEEEGFEA8?@G:?FA6@@(=@CHHEHIE??AABD@BBBB?9@ACCB;,854:ACC:@A::>CCC<CC9A@A:>
@0UY
CCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGG
+
@@<B=8;BBFB;DFIE1EF@:@>??BDEBB?B@F?4DDEE<DEF@;DFE)=7CE77=AD898>>>5;@A;@555:@>B:9<>9>>:3>88<?9?>3:34@A
@0UZ
GCTTGTAATACCAAAACCAAGAGCTAAGCATTTGTTAAAATGAGTGAAAAACTCGCTTCAGCAATGCAATGATATGTGGCGTTTAAAGTATGATGTTC
+
CCCFFFFFHHHHHJJJJJJJGJJJJJJJIJJJJJJJJJIJJJJJDHIJJJJEGIJJJJJJJJJJJJJJJJHHHHHHHFFFDDDDDDDDDCDEDEDEDE
@0V0
GTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCT
+
C@@FFDDFGD8FFGHFAF<FFBGGFFGGIGHIGGIIGHGEGIEHDDCGHIEGACGA>FHFCCGGEEEEFFFEBCAAAA@A;CCCCA@:@ACCCC:>BBCBB
@0V1
CTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGG
+
@@CDDFDFHFHDHJGJJIGGHJJIJJJJEGJJJJIGFHIIIIJDADGIIJJJIGGIGBFHGJGI@FHEIGGCGIJGHDHHHFFFFEDED@ACDDDDDDCD
@0V2
CCCAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTG
+
CCCFFDFFHHGGHJIIJJJJIJJJJGGGIIJJJJJJIJJJJJJIIJJJJJJJJJIJIJJIHHHHFFFCDEDDDDEDDBACDDDDBBBDCDDDDDDCDDDDC
@0V3
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCAT
+
@<@DD<3DFFF:CB?AACDE:CGHIFE<)1?CFFFB1?FF>B?@G<D@<;@D;@@EC@@AAFA<BDDDC>883:@B:@;AB<<:>@BBBBBBB>BB@(4>@
@0V4
GTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTT
+
@@@ADBDDADHHABFH;F>GGGACEBHGG@GFE;FEE@D<C<<?::BBB?G?9?FD9B<=FFGEDAHHGGGGIIIIC?ECAHFDCB?@@CE@@CCCCCACC
@0V5
CTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAA
+
@@@=BDD;=AD<CAFFB@D+<E:A@E>+2<4C<??4?DDCB;DBGD9D@BGEF4BFCGB?FDECD:)=@7@7=C)7@EEAA=7@B37?.;@@@>CB;;>
@0V6
ATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCAT
+
?@CADBDFHHGFHIIJIIGHHHAHGIJIJJIJEEGGIIIIGGGIEGIBGGACHBD@@A;?@CCCCDDD?BDDCCDCCCCDCBDDDDDBDDDDEEDD9AACD
@0V7
CTCTGTATCTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGC
+
@@@FDFFFBFHFDGGFIIIJIIIJJGGHAGGIIGII>HGGIJHGGGEGHIHHGHHFFFCC?ACEDACEDDBDBDD::@BDDDDDDDDD@>BDDB09@?C>C
@0V8
GTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATG
+
@@?DFBDDDBFDFEHGI<AFHIEIGIIIE?DGGAHDFHIGGII7;A;=@FGHIICGIHHHHEEFFFFFEEEEDEDBACCDDECC@AC?9>CCDCCC?CCD
@0V9
GAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTT
+
??=DA?DBDF>F<:AGFBH+ACGF3F?GFFFE)*?F1?CFFBFCD9?93:???BDFFFIBFFIB@:FG:@4@DED)=E;@3)==CC@)7;BB3(;6>>A>A
@0VA
AGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGT
+
@@@BDFFFHHHHAFHEIIIIIIDB07?CDCDDDDDDDDDCDDCBBDDDCDDDDDDCDDDDDDDDDDDDDCCCCDDDEDEDDDCCDEEDDDDEDEEDDDDDC
@0VB
GGGGGTTTGGGCTGCGTGCAGACGACGGGGTTGGAAGCCTGCGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCAC
+
@C@DFDDFHHGHHJIJJJJJIJJJJJJJJJBGHFHFFFFFEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDD9BBCDDDDDDDDDDDDBDDD
@0VC
CCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTT
+
@@@DFFFFDD<CFIIBBGHEHGBGFFGHGHIIF@CFFDDGFFHHIIGIIHIIIIIIIGHIIHGIGEHIIGI=@DGCA=7=?HCFC@C;;6@C>ACCCBABD
@0VD
CGTAGCCTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGG
+
?@?DDFFFHFBHHIGIDFH@HGIIIGIIGDIIIGICHIIIGIGFH?D8=@A=FDGG@GGHG>??CADDDFDDDD=@B@C>CCD9:4>CCCDCBBCCDD+>B
@0VE
GCACTCCAAAGGACCATGTGTCTGTTTTAGAAGTGAATATTCCTTCCATGAAGGCCTCTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCCTCCCTTT
+
CCCFFFFFHGHHHJJIJGJIIGIJIIJJJJHIIIJJIJJJJIJIIIJGIJJJIJJJIIJJJJJIJGHGFFFFFFEEEEDDCDDDDDDDDDDCDDDDDDDDD
@0VF
TTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGT
+
CCCFFFFFHHHHHJJJIJJIIIJJJJJJJJJJJJJIJJJIJJJJJFGIJJJHIJJJJJJJGJHHHHHHFFFFFDEEEEEDDDDDDDDDDDDDDDDDDDDD3
@0VG
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFDFFFHFFFHIGGGGIGIGHHJJIJIJGIIJGHIIIJIHGJCHIIHICDHIEHIIGIJIIIBEHHHFFFFFFFEEECA:B8=@CDACDDCCDDDCCDB
@0VH
CTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATC
+
=@+ABDDDD<DFFEIIIGHEHIIIIFIG@HEEGIDEGGE?FEGGCEGGGHIEBED;BFHFGGGIIIGICHGIIIEIHFDEFHDDDEECCECCCCC@CC@D
@0VI
GGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGT
+
CC@FFFFFHHHHHJJIJJIJJJIJJJJJIJJJFFHGIJJJJJJJJIJIIIJJJIIIJJJJIIIJJJJJJJIJJJJIJHHGFFDFEDCCCDDBDDDDEDDDC
@0VJ
GTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATCCTCTTCCTCTGCTTCCTTTTTCTTTTTCTCCTTTCCTTTGGCCCTG
+
B@@FFFFFHGHHHHIJIIIJIIIJJJGIJHHJJBGGIEGGIIGIIIIIJJJIJIIIIGIJJIIIIIGGGIGIHHHH@EFFFFEDEDDEEEDDDDCDDDDDD
@0VK
CATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCC
+
BCCFFFFFHHHHGJJJJIJJJJJJJJJJIJJJJIJJJJJJEHGIJHJJJJJGHHHHFFFFFFDDDDBCDDDDDDDCDDDDDDDDDDDDDDDDCDCDDDDDD
@0VL
TTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
CCCFFDFFHDDHAFHGHJGFGHIIGHGGHHGHIEEHGIDFHFH?FHBFGBFFCHGEFI=FGGDFEH5?AB;B?DECC5;@CDADCDDCB????CCCDDD@
@0VM
CCCCGAAGCTCCATACATCACTCTCTGTAGTGAACTTCCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTG
+
@@@FFD<@FFFDFEHIHFHABHHEHGEFHIHIIIGHHDGHG?@AGGFHFGHEHEIIIGGIGEAEHEEHHFFDDCDBDDDDDDCDC@??ADCACCBAAB>AC
@0VN
CTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATC
+
C@CFFFFFHHHHHJJJJJJIJJJJJJJJJJJJIIJJJIJJJJJJJJIJJJJJJIJJJJJJJJJIHIJJIIJJIHJJJJJJHHHHHFFFFFEEEEEEDDDD
@0VO
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
BC;BDFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJIJJHHIJJJJJJJJJJJIJJJJJJHHHHFFFFFFEDECDDDDDDDDDDDDDCDDDDDDED
@0VP
TGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATAC
+
<@@DDDDAFDHHDBE>BF<<AEBGGF>GIIIEBHH@DF>FGI@CBF?F@GHBHEBBFC@@=B=BCDF;FCCH:4@EGH@AHHHE:@7@BBC;>;>B6>ACC
@0VQ
GGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGGCAGTTGGAGT
+
@@@D?DBDHHH?F>HG;@FHHGHIGHEEHHIGAFG?DGGHGHIHIEIIIBCGF>GIDIIAHHHECHDDBDBCCBCB=CDDACCCBBBBBBBBBC@CCACA
@0VR
CGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHHGJJJJIJJJHIJIJJIIIIJIJJIIIJIGJIJIJJGIJJIJJJIJ8BGAHHHFFFFFEEEEDEEDD>?B?CDDEECDDDDDDDDCDCD
@0VS
GATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTC
+
@?@DDD?DFBDHFGGIGIHEB@BIBEAFDEEHGCEHGHIICGHG<9CDDDGIICGGEGFHHGFGIIIIIIIICHIGCGIGGGIEEGHEFHFCDBBE?CDC
@0VT
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGG
+
@@;DDFFFHGHHGIJFGIJCFFHIFHIJIIJIIJJJIJIJAGEGIIIJCAHCGHIGJIHIHEEHHGFFFFACCCCC;ACACEDDDDDDDCDBCCDDCC>CB
@0VU
GGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCT
+
CCCFFFFFFHHDHGGIJJJDHHHEHIIJJGGEHCDHIJGIJGGBFAFABDDEHBFH@FIIIJGGH5=>ABCDADDCAAA<?@BDDDB@ACBB@CCCCDCCD
@0VV
GGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGG
+
CCCFFFFDBHHHHJI@EGIFGIIJJJIJJIJJJJJJJJJJJJGGJJJJJJJIGHHHHHFFFFFF>CEDEEDDDDDCDDCDCCDDDDCDDD?BD8CDCCCCD
@0VW
TGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGT
+
@<8ABDDDFB?FBEFGIFIEB@B;+<@?EGBGDG<GFEEFIIEDGGDDDDBFE?C@B533>>;@B?B?>@;>>?9<?BA:>@>B@BBAA>>B?:A:>A>+
@0VX
CTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTT
+
@@@DDDD>AFFHDGGED@EIIG+?FHHCEAGH3C1:119C?DGAGHIDFDHIEDHGHIGIGG@BFGCH@FHC>@CHA>EHFEEEEDCCCAA>AC@C@@CCC
@0VY
TAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGT
+
CCCFFFFFFFFFHAGGHIGIJIJJAFHGIIIHGGIJIJJJGGHDHHGDDGHIIEGGIEFFHGGFHIJIJIJIGHBEEHFDDE@CACDEEEE?BCCDDDDDD
@0VZ
TGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
B@@DDFFFFHHGHGHGIIHIFGCHEGBCGIIIIIIIG3BEGDGGG?FGGECHGHGG@@CEH=AEFFFFFFCDCECBDBBBBCCCCDDDD>CDDDDDDCDB
@0W0
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
CCCFFDFFHHHHHJJGIJJIJJJHHHHIIJJJ?FHIFHIIJIJHIJIIIJIIHHHHHFFFFFEEEEEDDDACDDDDDDDDDDDEDDDDDDDDCDDDDDDDD
@0W1
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTAGGAGTAGTATAACCAGTGGG
+
@C@FFFFFHHHHHJFHIBFHDHIJIJJJIJJJIJIIJJJJIIJJJJJIJJJIJJIJJIJJIHJIHJJIHHHFDDBDD?CCDCDCDDBDDEDDDDDCDDD
@0W2
TCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCTCTCCTCTCCAC
+
?@@?;DBD3CDAF@?EFG:@FFF?86EA8)?;F@@FECCFFCFF>)8@FFD@AC@=..==??);;?BB@;;@A>AAABB>?A<A>???9(+<?A><@B9@@
@0W3
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
@@;DDDDADBHHDEB?EG@?EFGGEHBEHB@?1?@GHC;?F@8.=FHIIIFIECA=>BEEEB6;>ACC@>;;C?:::A:@@@;C>5(@4(>3:>ACDC>>>
@0W4
CTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGTACCTCC
+
@@@DFF;AFDFFDGGIEIIFBDHHHH9CEHGICGFIICH@@FHFHGGHHICFGHEG@@FHGGC@EEC@BCBCCCCA(55>CCB
@0W5
GGATGCTGTAGGCTTGGAGCTGCCTGTACAAATAGAGGAGGTCATAGAGAGCTTCCAAGTTGAGAAGTGTGTAACTGAGTATCAGGAAGGCTGCCAGGGAC
+
@@<DFFFFCBFAHDGBG<CCC>E@@BEEEHGHHEGIIG8DB0?<<?D<B9B?<DF88BCC@@4@2@EEEGCCAEH?A77.77?BAC;(;?9A?@@CC@6<5
@0W6
CTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGG
+
@@@DDDDA@?:?CFGHID6:GA?DGADEEEEG@@CAFAHA=;D>EEHFEEBBCC;@3>CCA>;?5>8?>A:::A>?C<<B@@BACDAA>@9>?:5><B9?B
@0W7
TTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCTAAAAAGCAGTATTAAGAATCATTTTAAACAC
+
@@<DDDDF>FHBHGIIGIGGGGHGEGGIGDGCHFHIIIIIEFHGIGIIFIGHHGICEHGIEHIIIEIIIIIIIIEECCDDEDFFECAEE(;>@DDDCCDD@
@0W8
TTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTC
+
?@<D?DDDHHFFHFHIIHIFGGEGIICHHIAGGEDGIFEHHIICDHG<FACG@CCGIDGGGH@EE<DDB;;B;CC=CDDDDDD:CCDCCDCDD>CCDCCC@
@0W9
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
?<@DDFDDDHFDD@FGFGGIEEGBAFHIGGIIIGBEG8?::DFFHEICD?@BFD=FHABFHACD?E=CCBEBE,;@C;>>CCDAA9<B@CCDDDDDBBCDD
@0WA
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
:?=B?DFAFDFHFI>EFACFHIIIIGIIGGIGHGGIBGHBHIGIGIIIIGIEEBFFIGG@F@@EHEIHHGGFCCCCCCCCC3?>>>BCDCDCC@BCCCB
@0WB
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJJJHHIJJJJIJHIJJJJIJJJJJIJJDGIJIIJI7EHHGEIJJJJCHHHHHFFFFFFDBDDDDDDDD;?BDCDDDDDDCCDDDDDDD
@0WC
ATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
@@;BADDDABF<=GDEEEB>CBHCDFGIGFB?BC9FFGGA@7;AHA3=;@CHGHG993=AEFFFEFEE;;3;??CCCE@CCC@CCCCC@5>>A8?9?CCA@
@0WD
GCTGCAGGTTGGTGAGCAGCTCGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGGTGGGATCCTTCAGGGCCTTCACAGCCACAAGCATCTTGTCCTTG
+
@@7BDAB>F>FFFDEFGE>BEEFGEGABGD@FGHGIIGIIBGDAGIIBGHIGFFEFB;?8@BCBCCCCCCBBBBBCACCC@BB@?BBBBBCCCCCCCCCCC
@0WE
ATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCC
+
???DDDDDDD+A?DB:CECEECBCA<FEFEFDEDA9?DCEA?DD@*B9BDDIIAEIEIE8@@ACC@@AA<@D?>=>AAADA;;=<=>A:A???0.9A:>>>
@0WF
CTAGGGAAGGCTTGGATAGAGTGGCCACAGGACCTCCTTCCCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTTCCAGGGGCACAATGGGGACCAGTTG
+
8?+=BDD>CA?FFII<@EE?HC91B>@;?8CBBDEEEGFG@A>@FAFBECE>=@E>EC9;?BB=<@A?B7;@@AB?>;@9=B998?BBABBB7<?8?(4:
@0WG
CCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCC
+
@@;BDDDDFDFFH?AEEFHFHEBE<CHGH@HHIIB?FGHICHGHII<GHD@AGHHGGGD@CACEEC.=CH7;B;?;@@CCACADC3;@C;??CBBBCCAC
@0WH
ATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTT
+
@@@DFFFFHHHHHJJIIJJJJJJJJIFGGIIIIJIJJJJJJIIFHJJJJJJJJJJJIIH@.67@DAHGHHHFFCFF@DEDEEEDDDDDDDDDDDDDDDBCD
@0WI
CTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCT
+
CCCFFFFFFHHHFJJJGIIIJIJJIJJJJHHIJJIIGIJIJIIDFHIIGIDFHHIIJIIIIJIIIGIJJJEHGIJGIGHHHHHHFFFFFEDEEEEDDCDDD
@0WJ
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
@@@A:;?DBDBH:EHBEFDFEH?<FGIIIDEHGGGDFEHHIIIE>@@BGGIIGHCD>DG:@GIG@EHAHBBBAC@>ACCDACCA??@?><<??ACCBBCC
@0WK
CCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTC
+
C@@FFADDFHHGHBGHHACFHGGIJGGGIHGHGDFGIIIJIJGHJJEIJGIIIIFDDDB@CDDDDCCDEDDDDDD5>59@CCCCDDDDDB?C:@@4>ACDD
@0WL
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@C@DDDDFDHGFFGFBEHCHHGHGGFEHFGGGA@FHGGFGIJEG<BDDBDFGHICGFHAFICCDEH@>EEHEBEFCEEECEEDDCB?3;=CA>C@CDDD
@0WM
GCAGGTTCTCCAGCTGCAGGTTCTGGGAGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGG
+
CC@DFFFFHHHHHJJJJJJJJJJIJJJJJJCFGIJJJJIJIIIIIIJJIJJFGHIJJJHHHHHFFFFEFEEEEEDDDDDDD@BB@BBBDC<ABBCDDDDDD
@0WN
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGT
+
@@@FFFF=CFADFFHHHFGHGGHIGGGHIIGGIIGIGGHGDDFGHIIIHEEB;BB@DHHEEHED?BDDCC;@@;@ACDDAC?AB@5>@>CCCCACCACDD+
@0WO
CCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCG
+
@@@DD?AD?FHFDHIIAGEHEGHEHIIIEHIIID<FEGEG@GBHIHIIEGIBGFHEHIGGIGHA=CGGIFE7>A?D7;;?7ACCC;@CCCECCCCC@>@CB
@0WP
TGGGGCGTCAGTGGGCTTTTGCTCCAAGGAGTGCCTGCTCATTTCAAACAGGAGCCAATGGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCC
+
??;:D:D0<CF:DFGEAF?9?B<?9BFGF8D/898B=8=CFC=FFFIAE>;=6;=?@DDDC(66@D@BBBBBB:>AA@BB?@BBAAB>4:AA>@:(4:@>
@0WQ
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCT
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIIJJJJJIJJJJIHIJGIIJJJHHHHHGGFFFFFFFDEDEDDDBDDDDDDDDD
@0WR
GTTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCT
+
@@@FDDDFFHF>FGIIGEHHFIHEFHAHHEGIGI?GGHGHIII@DHAFGHHIIII<FH?CB;CFHICCD@EEEACEHC@B9;55>5;@CD@:>:>@>@C@A
@0WS
TTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTGGTTGTCTTTATTTCTGCTCCTTTTGCTTTCGTCTGCCAGTCCCATAC
+
@@@DD8DDFDHH>@,<:CHCHGH:?2+229:19CFFAC>?F)0?)89*/08B/??=F;.==F>G;D@.7=).7=)=77;;7?C(.5=55(-5A>C((((,
@0WT
CAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGC
+
@@@DDDDDFHHH@>8AEHIFG?@EFHGHHAGEGB<FDGGDHIGHBHBFBCHCE@CG@AE7?;CEBBC@BDCCBBB;@CCBC?CCC;@ACCCCCCA?CCC@B
@0WU
GTGGTCAGCTGCAACATGGCCTGGCAGCCTGGCCCTTGAAGCACTAAACTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGT
+
@@CFFFFFFBFHHJFGFGIJJIGIIJJJIJIIIIGIJIJEEEHGIDEGGIHIJEEEHGGHIGIJIGIJGIHFHHHEDFBBEEEEEBACDDDDEEEEDCDD>
@0WV
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJIIGHIIJJJJJ@FHHIJIJHIJJJIDGIIJJJIIJJJJJEHHHDFFFFEEEDEEDDDDDDDDDEEEEDDDDDDDDCBDDDDDD?CCD
@0WW
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
CCCFFFDDDHFHHHIIJJHJJIIJCHJFHIIJJJGIJJHGJJJIIIIJJIJIJJJIHIJIJJEHHHFFFFDBCEEEDDDDDDDDDDDCCDDDD>CC@CDD
@0WX
GCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATC
+
@@@FFFFFHFFHGGHJGJJHDICHHGGHIIGGHGHEHIIIGIH?GGGGHGHCEEFGHGGIIHEGGIGJGEGIGIJIFIIIHAEEEFF;@BACEEEDEDCDD
@0WY
GCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGC
+
CCCFFFFFHHHGHIIJJIIIJIIGGJGEEHGIGJFHFGFHIGHGGHHIGIGFAHHGHII@FHIGHEDDHCEHHGHECEHDDD<AD??CDDDCDACCCABAB
@0WZ
CCCTTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGG
+
CC@DFFFDHGHDDFHG<CCFHIIIIJIIGIGJEGHIIIJJIGJGJIIIIJJGGEFEGHIGJJGEGEHHGFDFDDDDDD@CDDDDD<ABCDDACDCCCDDDD
@0X0
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCTGTTTGGGGTGGGTAAC
+
;??74@68DD8D<<EEE;CE@D*?*?911?DD>60?B;B<33B@CEIIA7==7@AC=CCC33=A7;7;;@AA@AA=(>>>A:39(55>A:1-50&5;&:>A
@0X1
CGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCT
+
@@@DDABDDBFHHGIII+A;EBHEGEDHD?1?D:B?G<@FFHG@C1.@;CAB>>9;>AACCBBBBC?9:@@>CC::CA>?9298??++8<B<><A<89>>5
@0X2
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCT
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJIJJJJJJJJJJGIJJJJJJIJJIJIHIHGGGJJIIIIIIGIHHHHFFF;BCDCEECEEEECCCDECDD<?BDD
@0X3
GCCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGC
+
CCCFFFFFHHHHCGIHIDHIJAFHIJJJIJIJIFHIIIIJJJJJJJJJIJJBFHIIIGHIHGIJIIJHFFFDCABBDDDBCCCB?BDDCDDDDDDDDD
@0X4
GTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGC
+
CCCFFFFFHGHHHJJJJJJJJHIJJJJJJJJJJJJIIJJJJJJJJJHHFFFFFDDDEDDACDDDDDDDDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0X5
GGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGAT
+
CC@FFFDDHHHHHJJJIIIIIJIJIJIJIHIIJJJJJIJJJJJJIIJJGHIGGIIJJJIIJIIGHFGHHHFFFFECEDCCEDDDCDCCCCDDEDDDDDDDE
@0X6
GCCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCT
+
CCCFFFFFHHHGHJJJJJJIJJJJJJJJJJJIJJJJJJJJJJJDDDDDDDDDDDDDDEDEEDDCDCDDDBDDDDDDDDDEDDDCDDDDDDDECCDDDDDDD
@0X7
CTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGC
+
CCCFFFDFGFFGGGGHHGHIJGHJJGGCHHD;;GADGIGIIIIJEIGGCHHEG?6AHEDD?B5;BDDDCACDDCCDB8<<CC3:ACDDBD7<BBDCDDACC
@0X8
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGG
+
BCCFFFFFHHHHHJJJIIJJIJJIJJJJJJJIJJIJJJJJJJJJJJJJJFGGIJJIIHEHHEHFFFFDCECCEECCDDCBBD<CDDCCDDDDDDDDCDCCB
@0X9
CTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGG
+
@@BDFDDFHHFGHJIJIIIIIGHJJIIJGHIIJIIJGGIGHJGGGIEHJ8AHIIIJHHHFFFFFEEEDDDDBDDDD?ABCDDDDEDDCDDDDD9BDDCDDD
@0XA
CTTCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGT
+
CCCFFFFFHHHFHIJJJJJJJJJJJJJJJIJJJJJJJJJHCGGHGIJJIIJIGJJIJJJJJGIIJJJIGIEDGHIJCHIHFHFHHHFFFFFFFDEEECCD@
@0XB
CAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGG
+
;??DAADDDBHFH@??E<ACFAHGIDB:D<??BDGHICFD9BF86CEHG<;:(=?@BD1@;>AAA;ACCC@(89??:5:@C:34>C09<<0-<9A>CCC@C
@0XC
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CC@FFFFFHHFHHJJEHIJJJGIIIIIGIEHGIIIGGFGDGHGIJ?DFIIJBBAEEEEDDDDDDDDBDD;B;BDDDDDCCDDC@C@C@CDEDCCDDAC
@0XD
CTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATC
+
CCCFFFFFHHHHDHIIJJJHHJJJJIJJHJIHIGIJIJIHHJJIJIIJJJJIJIJJIEGGIIIHIGGGIJJIJGJCFEEHHHFFFFFEDEEEEDDDDEED
@0XE
GGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATT
+
@@@ADDDDHHHHHJJJJJJIJIJJHIIJJJJJJJJJGHIIIJJJJJJGHHHHHHFFFFEDDDDDDDDDDDDDDDDEED>ACCDEEEEEDDDDDDDDDDDDD
@0XF
TAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
?@@?+=D?C=A:C?7:A?FFIIIE@HF@G?EF>BFGBGGFIEFIIIIIFE=/=FDGICG@EF>@EEFFF@CDDDDDDCC>@BBBBBB5===?B9<:@@>+
@0XG
GGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAAT
+
<@@DDDD?HDB?FHIBGGGIGGGC;BFCH@3D@B?;BFDGCCBDF>FD@FGHDHEBB>B>;(;>=CB?A?AB9AB9A>+4:CCC>79555?BA?CB<C@C
@0XH
AAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTT
+
<?@D?BDDFFF<F:CGB:<FEFIDH@@FFAFE@FF@DC@<FEFFG@?D?9BDF?FGB<?FEEFEGGIBECCFFFE;E7=CC@E>A>A6;96??BAB>;AAB
@0XI
CCCATCTCCATATCCACTGTGAGTGAGACAGGCATAGTTCAGGCCTTCAGGCTTGCCAGAAGGGCAGTAAGCCACTTGTTTTTCTTGGCAGAAATCTTTGT
+
;?<BD??DFF?ACBFB<4C<CD<<F?ABFE311??FF?9?FF9BFFE@@GCFFF@AF>FEFI9<;(;.7@ED;?CDBD@;@B?;;>>>A558?A5>>;A@5
@0XJ
CGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTG
+
CCCFFFFFHHHHFHIGGEHHIIJJGHIIIJJIJIJIIG?FGIJIIJIII@GGIHGIE@DEAA@CDDDDBBC??AABDD@>BDDDDDDBB<@<ACEAC>CC
@0XK
TGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTCAGGTC
+
?@@FBFDEDBHDDGIGIIBCFEFEGCFIIGHIIIIIIIGEB?B@;AFHIGHIIHEEEEDDDC@?CDCCD55<>@@CACBCD@<<BD>BBDDDCDD>A@CC
@0XL
CTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
CCCFFFFFHHHHHJJJJGHIJJJJIJJJJJJJJJJJJJJJJJBGHIJJIIJJJJJJJIJIJHHHHHHHFFFFEEEEEEDDDDDDDDDCDDDDDDDDDACC
@0XM
GAGGGTTTTATGTTGTTAATGTGGTGGGTGAGTGAGCCCCATTGTGTTGTGGTAAATATGTAGAGGGAGTATAGGGCTGTGACTAGTATGTTGAGTCCTGT
+
CCCFFBDFHHHHHIJJJJJIIHHIGFGIGIJJIJJJJJJGEHJJJIFHIGIJFEHIIIIJJJJJJJGEFFD?CCEEEEDDDEDCACCDDDFDCDDCDDDDC
@0XN
CTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJHIGJJJJJJJJJJJJJJJJJJIJJJJJJIJJJJJJJJJJJIJHHHHHHHHFFFFFEEEEEEDDD
@0XO
GGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGT
+
@@@FFFFFHHDFDGIJIEIIIAEFGHJIIIIIGGIBFDHDHEHGHGHCIIJIIGGGIFGHIGHHEHEHFDDDFFDEDEEED;ACDACBD8>@BACC@D?B<
@0XP
CGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGAC
+
=??DD8D?:=CDCGE@EBHE:CHE?C9CBHE@<C1?@<CDFG6DFGFFDF<**?=F@@C=@DED27@??CFD?@?;A@>6;A9?@>=:?B?<@A:5:>AB
@0XQ
CAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTT
+
=<@7DDADFABFFEFG@>GAE:+AC@HEIEHFEEDFG@FGI<:D>FF>BFEB?<?FFBBGE8DFD4D<8.BFI>D@FDFGE@=CEF@AAA>CF@?@;;;?B
@0XR
GGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCG
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJIJJJJJJJJIJJJJJJIDFIIJJJIJIJJJJJJJJJGJHHJJJHHHFFFD@BBDEDDDDDDDEDDDDDDDDDDD
@0XS
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGCAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@@@DD?ADCCDBHIE?GB:D@?@<E<EGI@@?FD@?GDHE::96FBAD'-75FA=;=@;567@D?D>C@A66@5?>ACBB@3,,5;>>89@@(>@ACC?BB
@0XT
GTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTGTCCCCC
+
CBCFFFFFHHHHHJJJJJICGIIJIJJIIJIJIJIJIJIIJJJJJJJGHIIJIJJIJJHHHFFFDDDDDDDDDDDDDDDDDDDDDDCDEEEDD?BDDDDDD
@0XU
CTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGC
+
@@@DFFFFHGHHHIJJIJJJIJJJJHJGIJJJIJIIJJJIJJJIIIJJJEHIJJJJJGGHHIJJJJ5=BD;CDDDADCCBDBDDDDDDDDDDDDDDDDDDD
@0XV
TCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTT
+
CCCFFFFFHHHHHIHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIIIJJJJJJJJJJHHHFFFFDEEEEEDEDDDDEDEDDDDDDDDDDDDDDD
@0XW
CAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCT
+
@CCFFFFDHHHHHJJJJJIJJJJIJJJJJJJJJJJGIJIJJIJJIIIJJJJJIJJJJJIIIIHHHHFFFFDEEEEEEDEEDEDDDDDBDDDDDDDDDDDD
@0XX
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@@@DDDDDFFBCF=EEGEHGEH<FEB?GHGEECFG>GFBBF?@FAFHH@F@CE=E.=?CEE7;C@D@C>C66>5=?(5>ACA::3?>>AC@>>CA0<B2>C
@0XY
CTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCG
+
@@@BD?BDFF;D?ACCEGA<@AFDC@CEDDGEFFBF:?FG??DCEBB??B<C@FB@88CFFIAE:86?9',33,289B<<993:+>BBAAABBAAB?<@B9
@0XZ
CTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCAT
+
@@CFDFBDHHDHDIIIHHGGIGCHBGIGIIGIGGGEHECHGIIIII@A?D?FEGHHGEDCHEHIECEEH??E;@DCEDCC>;>AAC;>CAB<?B9ACCDAC
@0Y0
CCCGGTTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTC
+
@@@DDDDDFFA>AE::FFFH<FF@@F@FFEFE:@FFEGFF@<(8B@FEIEEEEEB?15=5;9::A>:@AB@5?555&5ABBA:3>B>@?39>>?>A<@@>
@0Y1
CTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTA
+
CCCFFFFFHHHHHJIGGIJJGHIJJJIHIIIIFHIDHIIIJGEHGHHIHIIIJJEGHHIJJJIIGEGGEHIJIIHGIIJICHHHFDDFFEDEDECEECCD
@0Y2
GCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGG
+
CCCFFFFDFFFGACCBEFHIIGDGAHHEGEGEHIIIGGIBEAGHFG@A=@@ACCEHHE?EEDBDFFFFECC@ACBDCDDBBDDDCD>@@5<5>BDDCDACB
@0Y3
GCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCC
+
@?@BDFFDHHHFFGCFFIEHIJIGIJIJIEGGJIJEEG@FGGIIGHJFFHGHIGIJIIJEDGCADECEHHEDF?B;@CCCCEDACDCCCC?BDBBDDDCD
@0Y4
CCCTCTTCACGTAGGAATCCTCTTCATAAACATCTCGGGACAAGCCGAAATCCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCTGCC
+
8=8B;BD:CFHFHI=GEGBFDFFGHHEHICAH@<FHG;CDGHB?BA?FGHIGB8D@A?CHHH>B:B>C@ACCBB98@CAA>C<CC?(>>+4>CAACCC?@B
@0Y5
CATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCT
+
CCCFFFFFHHHHHJJJJJJJIIIJJJJJJJJJJJJJJJJGJIJIJJIIJJJJJIJJJJJIIJJJJHHHHFFFFFFEEEEEDDBDDDDCCDDCDDDDCDDDD
@0Y6
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
@@<DDADBDFHHHIG>FFCFCFEEHBEHIGHCHGII?FFBHEGHGIIGHHEEGHIGFGEAHG:?EEDE;7@D;>(6>(;=;;>A;>CCCCCCBBB:@@CC@
@0Y7
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJIJIJIBGHHIJIGJI@HGIGHIJJIGGHIJIIJJIJJJJJJGIJIIIIGHHHGECDDFFFCCCCE6>@B;ABD8ABB@CD@CDD8?C
@0Y8
GTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGC
+
@@@DFDF?DDFFHGIIIIEHHEGEGGIIGIDDHEAHIFIGADFFHIIIIJGEEHIIGGHCFGH<BCDB@CDDCCDDCD==BBDDDDCDDDDDDDB?B@@@
@0Y9
TTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTG
+
@@CFDFFDHHAFBHIJJIIIIGBGH1CFHDIGIEHIIIGJIJJGIGJIJ7CFHHHGE@CD?)?AECF@7BCE>@AEECCCDACCDDDD:ACDD>:ACACC@
@0YA
CAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJGIJJJBFFHIJJJJJIIIJJJJJJJHHHHHFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDEDD
@0YB
TGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGT
+
CCCFFFDFHHHHGJJJJJJJIHHIJJJJIJJIIJJFHIJJJJJJJJIJJJJJJJJJJJJJIIIHHHHGHFFFFFEEEEEED?CCDDDDD5?BDDDDDCDD8
@0YC
CCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCC
+
CCCFFFFFHHHHHJIJJJIJIJJJJJJJJJJJJJJJJJJJJJJJIJIJIJJJJJJJJIJJJJGIJHHHHHHHFFBEFFFEEEEEEEEDDDDDDDDDDDDD
@0YD
CTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCAT
+
@@?DDA?BFA<??BFGBF@BFDHD@FHC9EGH;??8??CBC9?B36?FH;(BBC3.=FHE=FGCB>C7AHDFE5>6;C35@CCCC<'388?A@CCEEA@CA
@0YE
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCC
+
@BCFFFFFHHGHHJIIGIJJGJJIJIGJGIGHHEHHHHFDHIGIFHIGGJJJJIJJJFHHHBHHHCEHGDDF5=ACE>CCCDCDDCB@ACCBDB)58:>CD
@0YF
GTGTGGAATCACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCACAGATCACTGGGATGCCCTACGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGAC
+
@?@DDDADFFHHGHGFIDBBEHIIGIIE3FHHIDHDGHIGCGE>DFHGGIIGEGIGG?8=@ADEDCGEBHD8>>D@C;6;>55;>C@CCDDDCDDCCCCDD
@0YG
GTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTT
+
;@?:DB3ADCB3CFGFEBBABFGIFFFEGIEE>DFGA??A?D??9?GC*9?/99B??BFCDFEGC=8CFC@;@@E?ABB'3=?BB?@AA??@B<>B5500<
@0YH
GAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCT
+
CCCFFFFFHHHHHJJJJJIIJIIJJJJJJJJJJIJJJJJJJJJJIIJJJJIIJJJJJJJIJGIIJJJJJJHHHHHFFF9?BD?CDDEDDCDDDDDDDDDDD
@0YI
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCAT
+
@@@ADFFFFFDHHFIIIJJGJFHEGHIIFHGJIGGGFGGFFHGGJJIIGEHGIJJGHGIDECEFDFFFACBD@CCDDC@C??5>>CCACC?ACC@:>>CCD
@0YJ
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGC
+
@C@ADFFFDHBBCEFGHHHIJGGHGIEHIGGIIIIIJG@FGIIDGDHGBGIIIGADHIIIIEED>ACEDDC?:;@BCCCACCCDDD@C?B>9922>A?@CC
@0YK
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGT
+
?@@DAADDF<DDHC<FDHCGCHAGB<FHADCDDAG<??*=88CCCAGH@@D@EH;@=@E;=>>EBBBBC>@5;CCA<<B<:>A@AC(+4@@4:@A:@>>5+
@0YL
GGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTCCAAAAAAAAACGAATGCAAGAACTTCATACATGAACT
+
@@@DDDDBBHHFFDGG>FIHEEEGGFEHIIGHIFGFHIJIHIGHIGGGGIIGEHGIEHJGHIEHHIJIGIHF@BBDDD<CCC@CCCDDCCCEDADECCC@A
@0YM
TGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCC
+
1:?ADD>DF>FD?:EBFDDE;@:AEGG@FIICF>HG:FB-<6<@CCCC@?@CD@DC::>8:@C<?8><<@BC:4>CC>AAA4>C>C@@C:4-555<?C@@
@0YN
GTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGGGGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGAAGTGCAGGGG
+
@<@DFFFFDHHDDGGBGGGIICGEIGEIFGG@FCGGEGE:BFCFGGHGGGI.@FG'9<573<C3?@B;9<<:>C>>AC0<BB8@<??CBB88?4>44>ABB
@0YO
GCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCT
+
?8=?DDBDDFHH?FEFBGHI>DHIGHEHHIIIIICEHHEGG@B@FHIIIGHIDB@BFF@FE5@@FC;DGCAGHHHFHEDBB>=>;@CCCCACCCCCCCCCC
@0YP
GTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@?DDFFFHGHHHIJJFGIIJGJDHIJJJJJJIFEGGIJIEIEIHIGJIIJJJIFGHHHEHFHFFF>>@DDDDDDDDBDDDDDDCDDDDDDCDDDDBDBDD
@0YQ
CTTCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
@B+ADDFDHHGHHJJJJJJJJJJIIJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJAHFEFFEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0YR
ATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCT
+
@@@DDD+BD?;AFGGG@>FHIGHIHGG>FE9C?*:CBGGEGGFHHHFE>B><4BFBE@DDGHIB<CDGGIIEEHEGHHD=;EHHCD;?B@CC:@A>ADD@A
@0YS
GCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAAT
+
@C@FFFFFHFHHHIJJJJJJJJJJJJJJJIIJJJJJGGIJJJIIJIJJIIIIIJJJJJJJJJJJJJJJJCHHJIIIJIIJJJIGHEHHHHFFFFFFEEEDE
@0YT
TTGCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTT
+
:?+=BBDDCDFFFHBEGGGGICEEG<EHGIGIGIGHIGHEHHGGIEHFDGEIEF>:FGF>GIIGG<BBDEHCG@AF>D>DHHGHEBECABDDFCBB?A>CB
@0YU
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
:=8BDDDDFBDDDHD<<CFEGGF@GEB?CFDHI;GEFD9??BFGIGGC<FFGIDCEDACE@CH>B>A9>>@;CC<=BB?@AC3>:CCCCACBB<B>?BC>C
@0YV
GCCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTT
+
@@@DDDBDHDDFHDBEC@FFGGGGFB?C?GBFBGHEHIEIGGGCGGFGIIEIGIHGCEHF@BCDDCEEDEEECCCCC@;=?BCD@>C@<CCDDDCDC@>AD
@0YW
CTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGT
+
@C;DDDFDDHHHGIIFGBCFHGHGIIIGIIIGDHGIIIIHFFHGIGCH>CEHIIIED=BEC8@BBCCCCCEDCECCB<><@B8<@BB<>BBCCB>CCCDCC
@0YX
TGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGC
+
?@@DBBBDHHAF?CFCCEEC@CIHEHE@HIIHIIIHIICFHIAHIGIIBDF?BGI@HGGGHGGEHIIIIIDBGDGG@CH77@=7AAEH>77@@@?C@@>C;
@0YY
GTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGA
+
CB@FFFFFHHHGHJJJIIJJJJJJJIIJJIIGHGGHHIJJIIGIIJJGGGFHHGCHIHEFGFDDDDDDDDDDCDDDDDDDDCDDD?CDDDDDDDCDDDD
@0YZ
CTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGC
+
CCCFFFFFHGHHHJJHIJJIJIJGIJJJJIJJJJIJFHHIGIIJJJJJIIGGHGIJFHGIIIGIIIJIGIIGIIGGH=EEFDDBDDDDDDDACDDBDDDDD
@0Z0
CCGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CC@FFFFFHHGHHJJJFHIJJIJJJIJJDDDDDDDDCDCDD>BDDEDDDDDDDDABDDDDDDCDEDDDCDDCCDDDEDDCDDDBD>CCCDCDDDD>CCB
@0Z1
CCTCTCCTCTCCACACCCAAGGGTCCCGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCT
+
C@@FFFFFFHFGGIJJIJJIHGCEGHIHJIG@DFIJJJJJJIEHIIGCHGFEGIIJJJGHGHH@DDFFCEECECCDDDD@<@BDDD@B>CCDDDDDDCDDD
@0Z2
GCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGT
+
??;:B@DDF??C8E+A??C<EG=3?GCGEDFA7@FFDF;CF@E(@'.?E9A=BB;?DD;>@>65(-;5->@>5>3:,>B<5(0<?@@88559>8:A24(8+
@0Z3
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJJJJJJJJJJJJJJEHFFEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@0Z4
TGGGCTTGTTTCCATCCTGCGGTCTTGGAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
?;?BDDDDDDDDA:2<A+:?FF@E>>E*??)0:B@>DAB18?6BEC1)BACA@DI377=CCCDD@D;;A>;>>>==>?>>,>3>3>>AD:38AA>A>>A>
@0Z5
GGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCC
+
@@BFFFFFGHHHHJJJJJIJJJJIJJJJJJGIIIJJDHI>FGGHIIIIIJJJIIJGIGIGII::ADFDDFEECDEEDDDDDBCDDD,9?CD>CDDEDDDDD
@0Z6
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
@C@FFFFDHHFD>AEEHHHBHHGIGDFHHE9??GHGDFGGGGIIIGGBCGGGGGIIGIDFB8ACC@>??CCCC??>>5:AC>C?CCACCBBBCCCDECCC
@0Z7
GGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGG
+
B@@FDDFFHHHHHHIJJJIHGIJJGIJJIIJJIJHHHHHFFFDDDDDDDDDDDDDDDDDCDDDBDDDDCDCDDDDDDDDDDDBDDDDDDDDDDCBDDBDDD
@0Z8
CCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGG
+
CC@FFFFFGFHHFFGIIEIIIGGEEGIG<CCFCHHIDGIIFEBD;>A@CEC<>ACCDDDDDCCCDACCA@ADCDEDEDDDDDDDCCD?BBB>@ADCD>>@
@0Z9
GCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGT
+
@@;BDBDDF<AF<CFFIIE+A<<ACFEEBGB?DGGIDCDGFICDFG<BGFEGDBF@FCD=CBFDFEGFEA8BEDD@;BC>;>;A@?BB@BB5>B@D>>@A>
@0ZA
CATAAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGG
+
CCCFFFFFGHHHHIJJJHJJIIIIIGIJJJEHIJJJIJJJIJJJJIIIHIJJJJJIJJJJJIJJHHHHFFFFFEDCCBDECADDDDDDDDCDDDDDDDDDD
@0ZB
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@;DD;DDHH?DFHIIEHICFICFHIIGIIIIIGIIGHGHIIIGGGIIDHFGGIIIGGIGG@GGHIIHHHEHEECB5-9C:@C4<49A::>@CCCCB+:?A
@0ZC
CACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTC
+
CC@FFFFFHHHHHJJJJJJJIJJJJJJJJJJHHJJJJJJJJIIJJJHIGHGHHIJJJJJHJJJJJJJJ=EHHHFFFFFE@CEEEDDDDDDDDDDDDD@BDD
@0ZD
GTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
?@@DFFBBDFHHGIJJIGIJIJIHIGIIJJJJJJGGFIJJJJJHIJIJIJGHJJJJJJJJJDHIJIIJJHGHHHHFFFDDEDDCCD?CEDDDDDDBCDDD
@0ZE
GGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAA
+
?<@DDDDFHHHDHIIIE<AFHHGCHCHGIIFBGGEHIEAFGDGHB9C<DFEFGH;BFBDHGGHG<EHAHGHGGGII>CHAHGGIHHHGADBDDB@DCCAA
@0ZF
TTTCCTTTTGTGCTTTTCTTTTTTTCTTTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTG
+
CCCFFFFFHHHHHJJJJJJJJJJJIGHIJJHGHIHIHHHIJJJIGIJJJIHIIIJJJJJJJJJJAHHHHHDFFFFFEEDEEEECDCDDDDDDDDDDDDDDD
@0ZG
GCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@@@BDDFFF<FHFIIDHGIGIHIJIJIJIIJIHIGIJIGGIIJIIIIIGHFHHHIHGIJIJJGHIGG@CECHFEFHFE@DC;CCCACCCA@;>;@@5>C
@0ZH
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
@C1BDDFFHHHGHJIIGFIIJJJJJJJJIJFHIJJJJJJJJJJJJJJJJIJJIJJJJJJIJIIJJJJHHHHHFFFF;@CDAEDD;CBDDDDDCDD?BDDDC
@0ZI
ATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCT
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJJJJJJJIJIJJIHHIIJIJJJJJJHHHHHFFFFFFFFEE
@0ZJ
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
@@?DDA?DHHGA?BBGIIIIIIIIIBHHGCBG:@FHDGHIGGGFGHB;@BGHHDEHGFFCBDCEEECDDC@@C@CC@CA@CC>C>CCCAACC>CC@BAACC
@0ZK
GACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTC
+
CC@FFFFFHHHHHJIJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJIIJIIJJJIJJJJIJJJJJIJJJIJHHHHFFEDCDEEDDDACADDDD
@0ZL
GGCGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTT
+
CCCFFFFFHHHHHJIIIJJJJHIJIJJIIIJIIIJIDHDGIIFGGFHGHGDFFFFFDA?BBDD2<BDDB@BDDDDCCDDCC4@ACDDDD89>BBDDDDDDD
@0ZM
CTTTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
=?8DBBDDF<BAFEHI<GBBCEDHGEBGIIB?GC:?FHGHIGHIGGGHBFEBHGH@CFGDFHGIIICHCHHGHHDECCC;@C;@@?=A@:CCCC9@CBAA>
@0ZN
GTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGAAGTGCAGGGGATGGAGACAGGGCGGCACTAGGTTTCATGCTC
+
@?@DDD@=<CD>DBGEGFE+@?E8CF?FFFI9BFD:=BFE=FFFEE;;AB;;D>BCCCCBB>A3;><B@B8??9@A<<?<8<95909?@@BBBBBBD:A>:
@0ZO
GCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCC
+
CC@DFEFFGHHHDEDCEHIJJJJIIHAFHIAHJJJEIIGIGHCGI;CHIHEHFFDBCCEEEDDBD?CDDDD??BBDDD@9B7@CDEC?@DBBAC9A>AA@C
@0ZP
CGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCT
+
?<?;AD?DDDADDA<<<C?:32C89C9?::9***::DA@DBBE;6??D9BD39===8.@=8=5'@',=3,(;;>5(-;?<5?;7(((:A(28:A3>:::3:
@0ZQ
CTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGT
+
@B=DDFFFHHHHHJJJJJJJJJIJJJIIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJIJIJJIGHHHHHHFFFFFFE
@0ZR
GAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGC
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJIJJJJJJJIJJJJHIJIJHHHHHHFFFFDEEEEDDDD@CDDDDDDDDDD9BDDCDDDDDDDDDDDDDDDD
@0ZS
CCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCTTGCCAGCAAAGCAGTAGTTGGGGTTGTAGTCGGTCATGATG
+
@@+BDDFFHHHHAEHIJGIIJJJJIJIJJJJJJJJJJJJJJHIGJJJJJHHHHEFFD?AEDDDDDDDDDCCDDDCDDDDDDDDBDD@CDDEDDDDDDDDDD
@0ZT
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFDEHBDHFIJIIJHIHJIJJCFH@FHIGGHFHHGHJIIJJJIJJIGIJJJEHFFFFFDEECDEDDDDDDDDDEEFEDDDDDDDDDDD?BCCD8CCC
@0ZU
CTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTT
+
@@<DDDDDFCFHHFHAEFDIHGEHHIIIHIGIIIIIIIIIGGGIIGIIIIIIIIIIIIIIIIIGGIHHHGGGIIHIIIIHHHFHHEEEECECCCCCCCEEC
@0ZV
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
CCCFFFFFHHHHHJIJJJJJJJJIJJJJJIJJJJHHHIJJJJJJJJIIFHIJJJJIJJJIJJJJJJJJJJJJHHFFDEEEFDDCDDDDDDDDDD?CDDACD
@0ZW
CAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCCTGTTCTGATTTAAGTACATTGAGTTCTTTC
+
@@7DA8@/60788ABB?BBBBBA8+8?8<<33>ABBB@BBBB<@<?B@B@BBAB@3:ABBBDB@>@BB4>>@@+>:@@DBBEBEB4:@A>@B@>>BBBBBB
@0ZX
CTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTT
+
@@=DDFFFHDFFHGIJIIIHHIIEHJJJIJIJI<FHGHIIIJJJJJJJIJJJIIJIJJIJGIJJJJIIJIIIIJEIJJIIJFHHHHHFFFFDEEDECCDDD
@0ZY
GCTTGAACCAGGAGGCGGAGGCTGCAGTGAGCTGAGATGGCACCACTGTACTCCAGCCTCAGCCCCAAGAGTGAAACTCCATCTCAAAAGAAAAACAAACC
+
B@BBDDFFHHHGFIJIJJJIIIJJJIJJJJIJJJJJJJIJJIIHHHHHCDFFFFEEDDEDDDDDDDDDDDDCDDEDDCDDDDDDDDDDDDDDDDDDDDDDD
@0ZZ
CGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGCGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTG
+
@@@?BDDADDHFDB;GEB?AFBFG:C8?FHIGGI9?<??*BFBB8?=)74CAG)6@:/=4(,3,8/(<81>?8<<?55@903(:@C4?0280>C@4>(4>
@100
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@@@DBDBBAABFDGDHDGB?AFCHIHH9EFH*?D:?B?FHHII;ABE=CHE@.7@;AE>CH7@>@@D>>@ACCA?B,;ACD3;@:5:5:::4>>A@<02:A
@101
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
?@;DBDDAFFHFHGIGGBBFGEGIAFFAEC1:?D?;FHGE?BFDHI<F@?BB;FGDCFEHGAGHI>C)?EHHEBBECEEA6@CB>CC@B;?3:@C:@:>:3
@102
CCCTCCTCCAGGGTCATAGGGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGGATAGGTG
+
@@@?BDD?D;DC?AB9A?E++)):D8?0:FG@06@;;FCFII?EFD?<BCCCC@BA?BABAB3559@@BB89<?BBBB@::3::>@@?AB>BBB8@?BBAB
@103
GCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATC
+
=?1=BDFFHHGFHHJJJJJHJIJJJJJJIJJJIIIGHIJJJJJHIIGFHIJJEHJJJIJJJJHIJJJJJJJJJIIIJJJIHHHGEDFEFFECEEEEDDDDD
@104
GGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGG
+
CCCFFFFFGGHHHJIGIGGGHJJGIJJIIJJJJJJJIJJJHHHHHFFFFFFFEEEEDDDDCBDDDDDDDDDDDD?CDDDDCDDDDC>AB>B@BDDEDDDDD
@105
GTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGA
+
BCBFFFFFHGHHHJJJJJJJJIJJJHHIJJJJIIJJJIJJJJJJJJJJJJJJIIIJHGFFEEEBDDDDDDDBDCDDDDDDDCDDDDDDDDDDDDDDDDDD
@106
TGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATT
+
@C<DDFFFHHHHHJIICGHIIGGHHJHJIJJJJIJJJJJJIJIIJJIJJJJJIJIJJJJJJJDHIJIJJJJJIJJJJJJIDHIIHHHHHHFFFFFFEDEEE
@107
GTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGAT
+
?@=DBDDFGHHGHGIIJGHGHEHGIIFBEGHEFAEHFBEBFACCEEDCCCDDDDDDDBBDCCDCDCDCDDCDDDDD5<>BCCACCCDDDDDDDDDDDDD@>
@108
GTTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGAGACTGTAGCAGTGGTGGT
+
=?1=A?DDFDFF?3:C;3:CF@F<B<FBBF><CG<F;DAFGBDC*0?FFB<*8B3<=C3).@EED4)))-;?BBDC.3/;??(,:<(5:B@BBBB:3+(+)
@109
GTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCTCAGACATGTCT
+
@@;DFDFFAFFHFIIJGFHHHEGHGGEGHEFEDFGGDC@>;CAEH?CEEEHD;?DDC?CCBCCC>AAC@DDDC:>@CC>@>A@?8<?CACD>>>:?CDCA:
@10A
TGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCC
+
@C@FFEFFGGHFDEGGIJHFHCGIGGHJIJJIIJIJJIJJI@FHIJHFGGFGFHGIIJIGIJIJHHHGFFFFEDEDDDDDDDDDCDD@@CCDBBDBB:@CC
@10B
CACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCT
+
@@<?D;;B?DAADB?CDEHGBC<FG:FAEGH4EG6)?9)009?B9B999DH3=8/88CFCF>=.8).7CCDHE)?:=?C?9',85>CCC5555>A44::>:
@10C
TGTACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCC
+
::14=DB=CBCFHEGBI@<DFH>B=E8)8?B9DHGEGHICDF@F4CADFHE@EGHIH77=;ABCCEEECA;>AC>>A@8=@?:B::2+8@DCDDCC>:>C:
@10D
GGGTGGCCTTCCCCAAAGCATGGAGGATTTTGTAGATCTCCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGAC
+
???=A)AADCD?CECB;EFII<82AEEE>?CB:??:9:??D@DD>DE?9?D??=;5AADC>CCA=?;@D:?AA<:AA=55;?/<???AA>>
@10E
CTTGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGC
+
@@@FDFFDHHAFHIJIJJJJIJGHGIJBGHEDEGIFGGGIICGHGIFHHFGIDHEEHG@EE?EHHHFEFDDBCED;AA?AB@AD,::>@CACDCCACC@CC
@10F
CGCCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCTCAGACATGTCTCAC
+
:?+4ADDFHHHHHHIJJJJJJJJJJJJJIJIIIIJJHII5@FHHIJJJIIHHHHHFFFFFFEEEEEDCDDDDDDDDDDDDBDDDDDDEDDDDDDCCEDED
@10G
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
?<?BDDDDDDD?::<C6@AEEF922+*:8)?:DEC9DD:D9)99DA(.((.8=;3.@56?AA).);;A??655(.(55=,81>3:>?3(+:>((4(+(&(&
@10H
GCATGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGT
+
:?+4ADEFHHHHHJJJJJJJJJJJJJJJHHJJJJJJJJJIJJJJJJJJJJJJJJIJHIJIJJJJIIJIIJGHIJJJIIHHHHHFFFFFFEEFEEEDDDDDC
@10I
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
+=1BDDDDD>DA?B>E3?3<11CEEEDEE?<DDD?BD;D>DB3BD<DC>D=A9A==@)37(:A>=A7;>A?@A>;;(--;>>A>>>;:555:A4(+(33+
@10J
CTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTT
+
CC@DFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJHIJJJJHHHHGGEFFFFFFEEEECEEDDDDDDDDDDDD
@10K
GGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGG
+
=B1ADDFFHHHGHJHIIIIJJJJJJJIIIIGHGHIIIJIJIIIJJJJIHFFDDDDCDDDDDBBCDEECCCCDDDDDDDBDDDDDDDDDDDBD@B>CCBBDD
@10L
CAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGG
+
@C7DFDDEHDFFHGJIJJGJGEHIIIIGIJJGCHIJJJIIGICGIJEHHIJJIIIJJJIFHGGBH=BEFFDDACDCDDDDDDDDACDDCDBDABDDBDD
@10M
ATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTG
+
@B:BDFFBFHHHHJIIJIJJJJJJJJJJJJJJJJJJJJJJIJJIIJJJJJJJFHIJJIJJJFGIHHHHFFFFEEEDDDDDDDDDDDCDDCDDDDDDDDDCC
@10N
CCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCGTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCT
+
@@=DDFFFHHHHFIJDHJJJJIJJJJJJJ@GHIJIIJJIJJJIJJCHIIHHHFFFFEEEECACDCDDDDDDDDDDDDDDBDDDDDDCCDDDDBD9BDBDDD
@10O
CCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCT
+
@@@DD?DDHDDAFHGHIIIIGCHGICDHIGE>FHIIEGGHG@EGHCGHEHFFDDFEEEEEEBDA3>C;@9<89?@22<>AABDCB8??(<8)28>5>9><3
@10P
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@;?DB?DBFHDBDHGHG<GHIEGC?EBBGGIIIGICH?>DEEEHHCHCIIIGGGI=FBFF@EG>EEAEE>ECCEC@DCDCC@>=BB34?>CCC>>8<8?>?
@10Q
GCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCT
+
@@CFDFDFHFFBFGGEHGEDGGIG@?FEHHGIIAG@CFF?FDAF@HG:DGHGIIIGE9DGEGICHGDFBFBFHDHGG@AH=7@DG@ECEFFHAA;@DDFCD
@10R
CTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTC
+
@@@FFFDDHDHHFIGGIGEJIIGIIIIIJIGGIGIJJIFHGIAGGGGIGGGCGHIJEGHIG=F@CGEGGEGDHHEEFFFDDADECEDCBBCC???BB@AAC
@10S
GCAGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
:?14ABDDDHGFFIIGIIIDGGGHIIIIH>?DFGHIEGICHGCH9BFGHEHCFGIFCCHIIJIJJECGIFHHDBDCCEDDDDD>@ACDCDCCCB:??B2
@10T
CTGCCACGCGGGCCCCGCTCCCAGGACCCCAGACTCACTTTTCCGCCATCTCGTAGAAGATCATCCGGTCAAAGTTGCTCGTGTGCTGCCATTCCCGCATG
+
@@@FFFFFHHFFHDGIJJGHIJGIGIGIHE=DEDFECCEDEDDDDDDDBDACDDDBDDCDDADDDDDDDDDCDDCDCDCCD<B?ADDCCD:ACDDDDDDDD
@10U
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
CC@FFFFFHHHHGCFHIGIJGIIIIICGIIIJGIJIJJJJIGIDFHGJHIEHHHIIJJJJIJJIJJGGHCHIJ7AD?CDECACCECDDEEDCDD:@?A?CD
@10V
CCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGAGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGT
+
?<+4ADDDADADFBGEF?AFFEEEDC?FFFE@BBBCDFB//?CFFIIB8??B@BABBBB>><-&0;?BBB::>?B>559?BB?ABABA@?BBAB??<<)5<
@10W
GTATAGTCTTTCACGGAATCAAGGCAATTTCTAGCTGCCAGATCCCTGTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTACAC
+
@@<DFDFFHDHFDIBFGBGHGIFHGGIECFCDEGHEEGIIHEHI@GCHBF>>F>?BG4=8B<==@FADHGI@@C>EAH=@(6;>AC>;?CDCCDD@ACCC
@10X
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
CCCFFFFFHHHHHJJJFHIJIJJJFHIJIJJJJJJFHIJJHIIJJJJJIJJJIJJJJHIHHHHHFFFFCEEEEEEDDDDDDDDDDDCEEEDDDDDDDDDE
@10Y
CTGGGATGCCCTACGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCT
+
??<ADDD?F?C?>FEG+AC@CC@EG?G<E1:9*CB<FEG<F0??4BDFG>DCAGGB.7@EC=AEEEE77??=AC>>=-55(5><CCBB:>9::(:@@>CD:
@10Z
GTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTT
+
C@@FFFFFGHHHHJJJJJJJJGIJJJJJJJJJJJIJJIJGIJIJJJJJJIJJJJIJJJIIIJJJJJJJJJIIJIIIHHHJIJHHHHHHHFFFFFFCCECEE
@110
GCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCAT
+
@@@FFFFEHDFHFEGHFBHFHE?F?:CGIEHHGFCGIDBDD<>CC8CA>C>@BCDCA@BDCCD28;?AB<:4:>@CDD>CCCCC@DDCDDBB>BB<3:ACC
@111
CTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTG
+
CCCFFFFFHHHHHIJFHIJHIIJJJJJJJJJJJJJJJJJJJJCGIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJHHHHHHFFFFFFEEEEEEED
@112
ACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGG
+
CCCFFFFFHHHHHIFHIIIJIIJJJJJJJJIIJJIJJJJJJIEHGJJJBFHJGIJJIIIGHHHHHFFFDEEEEDDDDDDDDDDDDDD>CABDDDDDDDDDD
@113
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
B@BFFFFFHGHHGFHIJJJJJJIIIJJJIJJJJJJJJJJJJJIIHIIEIIIJJJIIIIJBHHIEHJH5AHFFFFFEEDABDDDCCDDDDDDDDDDDDDDD9
@114
GAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
C@@DFDDDHGGFHIIIIIJJFEEHGHGGHIIFGBFEHGIJJJ?DHFFHIJJJJIIJIIIE@EEEEFFHFFFEDDAEABDDDDDBCDACDDDDCDDBBB>B
@115
TTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGG
+
?@??DDD?;DDDDIIIBB@GHC@DGF@EDHIDGHGHIFGFGH@FGGIIGIIIFHHE>A@C@>;5;>C@CCCCC@??CCCACCCBBBBCCCCCCCAABB5<>
@116
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAAT
+
@@@DDFFFHHHCFHIIIIGIIJIIIJIJJJJJJIJGGDHIJIJJIGIJIIGHJIJGGGIIJJGJHHHHHFFDDFFDEEEEEDDDDCDDDEDEDDDDDDDDE
@117
AGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTG
+
CC@FFFFFFGHGHJJIJJJJJIIJGGIGHGHJJJJGIJJJJJGHHHIIJIIIJJIJJJIGJJJJIJIFFHHGFFFDDD;?B?BD=BDDDDACDDDDCDD:?
@118
GAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTC
+
@@@DDDADDHHAFHIGI@HHIIIIGBFHIIGGIEB<BFHIGIGGIECF@FEHI@FHGII@EHHHDHHFHE??>ABCCCCCCEDDCCCCCCCCCCC?CC>AC
@119
CCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGGCATATGC
+
@C@ADDDADF?DHHIDIIBGGGHIGHFGBHCGEGFGF@DFHIIIGH>?EFGCHEFGEICHIIEIICE@EDGCGH=7?D>@B@CEACC5;AA@(,8:CCCC
@11A
TGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGT
+
@@@FFF?DHHHDAHCAD>I>EIGGGHCHBGFABGGGHD<FEGEG>DG>GIGEH?DHGGIGIGGGC:@FGEB>GGEHDCE@BDF.>C>ACCCAC5,55:5:5
@11B
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
@C@DDDDDFHHFFFGHHIIJIGGGHBHIIIGGHIFEGGBEIGGHE@FG@DAF>F<CF=CEEECG>C>CHHFF=@A<6>;AACCCDDCC?@B:@>>::(898
@11C
CTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGC
+
CCCFFFFFHHHHHJJJIJIJJJJJJIJIJJJJJJIJJJJJJJJJJJJJJJJJJIJIJJJJJIJJJHHHHFFFFFFCEEEEEEDDDDDDDDDDDDDDDDDD
@11D
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
BBCFFFFFHHHHHJJJJJJJIJJIJJJJJJIJHIJJJIJJJJJJGIJJIJJJIJJIJIIICHIIIIEHHFFFFFEE@CEDCDDDDDDDDD>ACCEDCDDDD
@11E
CTGGTTGTAACCCCCTGTGCCAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCAT
+
CCCFFFFFHHHHHIJJJIIGIIIIIJJJJJHIIJJJJHIIJJJIIJJJJJJJJJJJJJJJJJJJJHHFFFFEEEEEDCDDCDDDDDDDDDDDBDDDDDDCC
@11F
CTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTC
+
???B?DDBFF<F<:AG@4F:<1+2:?E?8):?:B?B?090?4D?////*//8B8);67C=7DDE??=;A7)7;@;555;,5;B'2<(++++++:>A:3<2
@11G
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHGHJJJJJJIJJIJJJJJJJIIDGHIJJJIJJIJIJHHIJJJJJIJJJJIJJJJJJJJIIHHGFFEECDDEEDDDDDDDDDDCDDDCDDD8
@11H
CTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTT
+
C@CFFFFBDHFHDIGJJHHGHHJIIIGHIIIIGHIHG>@GGIJIGIIIJJJIIICGHIGGHIIJJIGGIDIGIJEHGGDGEAHHGHBFFFDE@EEEDEEDD
@11I
GGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTT
+
BCCDDDEFHHHGHJJJJIJJJGJJJIJJHIIHGIIJJJHHBDFFFFEEEEEEEDCCDCDDDDDDD@BDDDDDDBBD2?CDDDDDDDDDDDDDDDBDDDDCD
@11J
CCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTT
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJCHGIJJJJJJJGIJJJJJJJJIJIIJIJJJJJJJJJIJJJJJJIIHIIIJJHFHHHHHFFFFFDEEDEEDDD
@11K
GTCTTTGGTCGGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGTGGCTCCAGTCTCCCTCCTGTTTGCACAT
+
CCCFFFFFDHHHGGHIJJJJJJJJJJIJJJJJJHGIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJHHHHHEFFFEEDEEEDDDDDDDDDDDDDDDEDDD
@11L
GGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCGGTTGGGGGAGTATAACCAGGGGG
+
+8?DD=BDBDF<FBEF9@FF=GEFH?42CHAF31CF?G<*??0:B9?DGGCCBF=;(8@5@==CEEF;AEBFD>B-&09&9>&5&&)+9>4@(+>?(5>B
@11M
CTAATTTCTCTCGCTTGTTTACCTCAAGTTCTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATTTTTC
+
1=1DAAD=<A?A)AEE1+3A,<C4<A9+AA4:*:CB*1*:1*?*9B**00??9B49B**98?==BC3@CA(()7@@A.7A)=7??
@11N
CATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGG
+
@?@?BD;B:A<<DGFFFIIIAEGFFEFFFDGEFFEE@FFBFDFF9@9???DBFFIIID@FFGDEEEEE>BBD>@DCCCCC=@;;;(;835;=83<?>AA?
@11O
CTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTG
+
8?@ADDB?A<<CF2@2::?FG:<?EBBFFEGI@BGCGFDBB?FFIIICBBBCCFFDCC;=CECEF965;<>BB:@D;-55=B(,5>:AD@>A>BA>59&5
@11P
CCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTT
+
??=DD+=B:?B;C@B@::<F?4?@FE93CCE8CDD>?9?8B?D)??9?88?CC9@ACB@AA3AD>;@CCAAA>>777;7)6.6;>AA55;A>>ADAAA=<5
@11Q
CTTTTCTTTTTGAGGCACTCTGCCATTAATCCCTTCATGGCTTTTGGACAGATACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCAT
+
@@@DDDDDDFF:1?+AE93A:CEGAEHAF4<*:?GEA4**?)09D<6DBE;*/=F:BF1.=(5@=@7==)77=?B@D).;=3(((-->@>3;(8<?A?@<4
@11R
GGGGCGTTCCATTGCATAAAGACTGATGGCTGTTGTACTCCTCCAATCGGCTACAGACAATCTGCCAAGAGGAGAAGAATGATGCTGGGCTGAGTAAGTT
+
@C@DDDADFHHHGEEGHGIJIJIIJJJGGHGGHHHJGGIJICIIIGIGIIGGEHHHHFFFFDCEEEEDDBDD=?BDDACCDDDCDDDDDBD>?A:>ACDD
@11S
TCTGTTTTAAGTTGTAATTCTTGAACTTCTTGCTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTG
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJHIJI4HHIJIJJHIIJJJJJJIJJJJJJJJJJJJGGIIHIFHIJJJJIJJJJJJJJJHHHHHFFFFFFFEEEE
@11T
CACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGG
+
CCCFFFDFHHHHHJJJJJJJJJJJJJJJHHHHFFFFFDDDBDDDDDDDDDDDDDDDDDDDDDDDACDEEEDEEEDDDDDDDDDDDDDDDDDDDDDDDBDDD
@11U
GGGAGCCGTATTTGGCGTACTCCACGATGAGGAGGAGCGGGCCATCCTGGCTGCAGGCCCCATACAATTTGATGACATGTGGGTGGTTGACCTGCTTCAGG
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJIJJGHIJJJJJJHFFFFEEEEEDDDDDDDDDDDDDDDDDDDDDDDEDDDDDDDD<BDBDDDDDDDDDDDDDD
@11V
CACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTC
+
@CCFFDFFGHH?FIJGIIJJIGIJJIJJJJIGHIJJIIIJJJIIDBDDDDDDDD@?CDEEEEDDDDCCDD8@B?BBDDDDEDDDDDDCCDDDEDCCDDD9B
@11W
GCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGT
+
CCCFFFFFHHHHHIIJJJJJJJJJJJGIIJIJJJJJJIJJHHIJJIJJJJFJJJIIHIJJEIJJGIIJGHEFFFFD>AD@DDBBCDDCCDDDDDCCDCBD5
@11X
GGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTG
+
<?<A??DB>D?BDFGEB4C9CF?ECCDHHGB9CFH4CG@DHIEHII::BB<DG?B??B3?FF=<E<8<=;(6>AC;9>@B@?A@@95&+((+:?58:>(((
@11Y
TTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJFHIHHJJJJJIJJJJJJJJJJFHJJJJJJIJJFBCDDEDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDD
@11Z
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAAC
+
?@@D?@>DFBFDDECDHAHCGHFEGDDHB9@BBADH=DB??8=<CAFCHIC;EGHEHCEHCCEEFC;?DCC;=;@B5>;;@@CCCAC>>CB9<009<@CC@
@120
TGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGC
+
CCCFFFFFHHHHHJJEHIGHJJJJJJJIIJJJJJJIIJJJIJJJJJJJJJJIJJJIJJIGIJJJJJJHHHFDDDDDDDDDD@CDDDCDEDDDDCDDDDDDD
@121
CCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGG
+
CC@FFFFFFHDFHIIIHGIJIIIHIFIIIFHHIGIGIJIIIIGGJIIJGEGIHEHIGGGGHEDEGGGGGFHCEEFFFEEEEDCCCDDD>CDDDDBD?AD>@
@122
ATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGC
+
??<DAD;A=?CD3C>:@@EA;FEEEFE@<EE@EDDEEBDDDEIIAD<?BA)??DCC38;8=@D=@@CEAAAC)59?,9>?8>A:>>A>A??>8>?<<<>:A
@123
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAAT
+
@@@DD;DDFHDFFGEBHE?A:CFEA?E>BD?E?FHGIGCCGFFEFFBFHIGIBEG<BDDAE@EEHHH>HEEEEDDCC:>@(;>@>@;AAA>>CCCCC@>CD
@124
ACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCC
+
@CCFFFFFHHHHHJJIIHHIJJJJJIJJJIJJIJFHIJJJJJJJJJJJJJJJJJJIJJJJJJJJGHIIJJHHHHHGHFFFFBDEEEEEEDDDDDDDDDDDD
@125
CTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTC
+
CCCFFFDDHHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHHHHFFDFFFEEEEEEEDDD
@126
GGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCC
+
CCCFFFFFHHHHHJJJJDDDDDDDDDDCCDDEEEEDDDDCCDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDD@BBDDDDDDDDD@CCDDDCCDCCDDDDDD
@127
CCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATA
+
@?@DDDDDHFHBHIG9BBCGGHIGGIDHHHDIEC@8EDG???FDFIFHGHIIII;@FHG8@GG=DEHF7?CCDEE@CCCCB<A>CBBCC>5>>C?9?CD
@128
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
BBCDDFDFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJIJJJJIJJIJJJJHHHHHFFDFFEDCEEDDDDDDDDDEDDDD9<BDBDDDE
@129
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
CCCFFFFFHHHHHJJJJJJJHIJJJJJIIJJJIJJJJJJJJJJJJJJJIJ@FGIJH=BDDDDDDBDDDDDDDDDBDDDDDCDEDDDDDDDDDDDDEDDD
@12A
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
CCCFFFFFHHGHHJJGGIJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJIJGIIIJJJJIJJHHH4=B;CDDDACBDBDDDDDDDDDDDCDDDDDBBBDDDD
@12B
AGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@@@DDFDDHDFHDEGGCEEHHGHHIGJFGIGGEGIIJIJIIIIIJIGIJIFHIHHHHEFFFFFFEEEEEEDDDDD@>CC@DCCCDDCCC?B<@BDDDCC
@12C
AGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGC
+
CCCFFFFFHHHHHJEIGBHHGGHIJJJIEEHIJIGIGGGIEBDGHIC=BGCFGGIGIIJIFH=CDFFFDFEEEEDEDACCDDDDBCDDEDCDCCCDEECCC
@12D
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@@@FFFFFGHHDDGBHFHDDGHHGGHHEHIGBCDGIJIIIIJGAFHIBHIHIGII@CHHEEF@D7?BAEACC3;A@5>>>5:>>A<C:@C@CACDBCBB:@
@12E
GGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTG
+
BC@DFFFFFHHGDGJGIIEGJJJIIEDBDBCCCCDD>CA@CBCDDDCB>CDD@?8BDDBDDDEDCDDCCDDDDDEDDDCBB<@>CCDDDCDDDCCCACCDD
@12F
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
CC@FFDDFGFFFHGGHGJGGIJJIIGHIGIJEHJIEHIEHIGGEEBFBFHGIJ=DGEHHFFFFFDEDECCCDDCCDDDDDDCDDDCCDCDC@CCCD@CDCC
@12G
GCTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGCGGTTAGAGTAACAGAATCCCACACTCTGACGGGGGGTTGCAGAGGCCTTCC
+
?<??BA;BAD:8DEE3+23AB>E<+2:?CE??B<1**::?*0?)7(?*/88).)/8)==))=ACD3=).)7='3;>9)0&(+(+28704:>A
@12H
GGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGT
+
@@@DDFFFGDBHDBGBAEBFHEHIHGBBFHGIGGDDBDDCDHDGHDDDFEF?BABFGCHGA@E=E=ACE>7ABCBDC;@@@@>@A3-81<@8<?,,5<<?5
@12I
GTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAAC
+
@@?DDDADBHFHFAEGFEHIIIIIG@FHIH@F<:D?DDHHEEGGEAFE??FBCHC;FDCEFG=ACE7A7=?CDDEDECCCCC>>CAABBBB@A?CCCCCC@
@12J
TCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
@@@DDDDDFAABFB:AFGEGG<FAFH=GGIIIIGIIA@EHIIBBBGCGGGIG@BCH.=CG>EDCC@A;CHAC@DEEBA9(>>6;;>=?:<5?98@588@<
@12K
CAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAAC
+
@@@FDDFFHFFHFHHIJJJJJGIJJJJIIIJJJJFHIGIJJIGJJJIGGIIJJEDHIGIJHHIIGHHHHIJGHIHEHHHHFFFFFFFEEE
@12L
CCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTG
+
?@@DDDBDFDDFHBH@FGFHGHIGIGIGFGGGGCHGGIII@D>GHHF;FHGHGGHIEG:CFFFEGIH'9>B>>?CC@C(:<ABBBB@BBCCCB@CCCC:::
@12M
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
CCCFFFFEFHHHHJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJBHFDFFEEEEDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDD
@12N
CTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTC
+
CCCFFFFFHHGHHGIJGHHHIIGIJJJJJJJJJJJJGHIJJJJJJJJJJJJIJHIJJIHIIJJJJIJJJJJIJJIJJJJIJJHHFFDAACABCCCDDDEDC
@12O
CAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGC
+
@?;D::B2ABFDDHFB?EDEFHHGI>FFHIEFHIABGBHCGBDC?BE>9/?BFHHIFAGEHDFAE;CEEAHFFBBD;CCCBCCC>>@?C=?@BB5.5>AC@
@12P
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCAAGCTACTG
+
@@@BDA;DFF??FG?>FDBB?)?CGF<B>=6BAGEA?8?DDFIIII;CEFD9=>=7?EB>8<'=;;>>(59@B<@AA35><8:99AAAB2<5<<?B:>>>:
@12Q
CTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTTTCTCCAGGACCCAGGGAAATGTTGCCCCTGGAGCCCAGTCCCTGGCAGCCTTCC
+
@@CFADD;:CFFHIEIGIHIIIIIIIIEHGHIIIIDI?FAHGEGDGHIIIIGIHAEGGCHGGEHECEDFD>@DCCBA=A5=BBDD@CDDCCBDCDDDDDDD
@12R
CAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTC
+
@@@DDDDDBDFHFIBBDF>DDAFCHIGIIEHGGDHHGCGIIIIGIIGGHIDHBD@FHHIIEICHHEIGIIFICEHI;@EEEFHFHHEDCEECCCCCCCCFC
@12S
TTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGA
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJJJIJJJJIJGIIJJJJIJJJJJGIJGJJJIIJIJJIGIJJFIHHHHHHHFFFFD
@12T
GTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGGTTACTT
+
@?@DDDDFHAFHHAEGHGICFCGI@9CBFH@ED9C>EEHCDG>FBHEHDFHBFHIEGDGIG>DEGH8BFHBCFEHA?=@DGHHHCECE?@CDCF);>C>@E
@12U
CCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGC
+
CCCFFFFFGFHHHGIIJIJIIJGJIJJIJJJJJJJGGIJIHHIGGGIJHIIJHIIIJIJIIIIIHGIIJJJJJJJJIHGICHEHFFFFFFEDEEEEEDDDD
@12V
ATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTT
+
?@<D7D;BFDFHBHGIE?EAH>B@HHIG<@F@GH9FFDD8D>>FG4DDFCBHGHI;FFH=;FCCGCEGGHGIEFFF;=7;C>@B<;3;?@:>CCCCC(44:
@12W
GGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIGHHHHFFFFEEEDEEEDDDDDDDCDDDEDDDDDDDE
@12X
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHGHJJJJIJJJJJJJJJJIJJJJJJJJJJJIJJIJIJJJJJJJJJJJJJHHHGHFFFEEEDEEDDDD3=B>CDDDCDDDBDDDDDDDDDDD
@12Y
CTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCT
+
@CCFFFFFHHHHHJJJJJJJJJJJIJJIJJJJJIJIJIHIJIJJIJJJJJJIJJJJJJJJJJJIJJJJJJIJJJIIIJIJIJJJJHHHHGHEFFFFFFFE
@12Z
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
@@@DDDDDFHDFHGBGHBCEHGCEGIHEHGHCFHCGHBDGGG@DHHIIHA@??DGHBFEEHIIGCHIICHIIIIGHG>EHFF.=BBCCCCCCEECC>CCCC
@130
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGGGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTG
+
@@@FDDEDFD:@DEGGHEGG@BDGGFGIFG@A>DEDFEFGIIGGHGADGEHDF;@E:DA@CHEHD';6=ACCCCCCC>;;5:>:>A:>?:@A>C:99+<C8
@131
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFDFFFBFHFGGHIBHIEBHDFFFFBBHBFGGGIF0?D7BBBBBCC@A@@DCEE>A>ACDC?BBACD@BC@CCCCDCCCCDCBDACDCDB::@>CCC
@132
GACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTT
+
@;@DDD??=DDDHF<EADFEDG@:A@???DBDFHI;FIB@<9',3=559>93@;>CC@:C@::3234+3?9599&4444<C@:4A4:344+4:+<92:44>
@133
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
@CCFDDAD>DHH@BFIIDIIIHIIEHIBFG8CDGGHIIIIIIGIG?DHGHGEIIIIGIIDIIIGFFFFEDCCECEDDDCDDBDB<><9>>CAC>CCCCDD
@134
TGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATAT
+
@CCFFFFFHHHHHJJJJJJJJDIJJJJJJJIIJJJJJEHIJJIJJIJJJJJJJJJJJIJJJJJIIHHHHHBFFFF@AA@DDDDDDDDDDDDDDDDDDDDD
@135
CATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTC
+
CCCFFFFFHHGHHJJJJJHIJIJJJJJIIJHIJJJJIJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJIJJJJJJJJIJIJJJHHHHHGFFFFFFEEEEEE
@136
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJEHIHIJJJIIIJJJIJJJJJJJJJJJJJJJIIGIIJIJHHFEFECEEECEDDDDDDDDDDDDDDDDDDDDDD
@137
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFFFFFHGHFFIIIJIIHHGIJJJJJJJIIJIJIIIIJJJJJJJJJIJIJJIJ=FHGIEBEHHFHFEFFFFCCE;A@;CDDEDDDDDDDDDDCDDCDD
@138
CCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGAC
+
@@<DDFBDFHFHFHIIEHIIHGGEDFGDEGIHGIHGIIEEBGHIIIIIIIIIGDHHHIIIGCGHFHIGGEHBHIIIIGE@EEHHD@DFFFFDDDCECBDBD
@139
CAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTC
+
@@@DD?DDBFFDA9EHHGB>G>HGEEG@FEG9CGBF@DH;?B>FD@GB;CGGGIICG?7ACA>B@BDC?C>CC5@A359==;05@>4:ACDD@@@DDA>CC
@13A
CAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
CCCFFFFFHHGHHJJJJJJJFGIIJJJJJIJFGIJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJIJJJJHHHHHFFFEDDCDDDDEDDDDDDDDDDD
@13B
CGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAG
+
CCCFDFFFGHFHHJJJJJJJIJJJJJGHHIICFHIJIIJIIJJJIGIIJJJEHJJJGJJGGIJJJJJJIIIGHHH?DDEFDEDEED;BDDDDDDDDDDD
@13C
GGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJBGIJJJJJJJJJJJJIJIJJIJJJHHHFHFFFFFFEEDDECDDDEDDDDDDDEDED
@13D
GCCTTTTGTCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGTACATCTCCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGG
+
@@@DDDDDFFFFDEFFFB:E?E<FCBFEFCGFF<BCDGFIIIEF@BBAAD@EECEAE?'';@AAABBBB@BBABBBBBBBB@@@BBBBBBB@BBBDB:>9<
@13E
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
CCCFFFFFGHHHGJJIIJIIJIIJJFHHIJJJCGHHHIIJIIIHHIGEHJJIGHHHHFFFFFEEEEEDDDDDDDDDDDDDDDDEDDDDDDDDDDDDEDDDC
@13F
CATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTG
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJIIJJFHIJGHJJ?FHIHIHJHJJFEIJJHIGHHHHFFFFEEEEDD?@BDDDDDDDD@CDDDDDDDDDDDDDD
@13G
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCTTAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFDFHHHHHJJIJGHIJJJJJJIJJJJJJIJJJJJJJJJJ9CHIIJJJJJJJJJGHHHHFFF3;BBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@13H
GGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
?;@BA>BDBF?<DGHEHGHIABA>@DHGGGBB:):?DDE>:??DBG94?;B;BH>F@@GE:CGDC@BAD>A@>>;CAC>CCCCC>?BB?5:>??024@C?B
@13I
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
CCCFFFDFFHHHHJJJJJIJJJJJJIIJJJJJJHIJGIJJIJJJIJJJIJHIGHHGFFDBEEEEDDDCDDDDDDDDDDDDCDDDDABCDDDCCDDDDDCCD
@13J
GTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTCGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGC
+
@C@DFFFFBDFFFIIIIGJIGHGHIJGGGHGIIEIGGID?DFHGGIBGGIHIIJJGIIHHFHHIHGIGHADB@BDDECDDDDDACCDCDCBDDDDBBBDB
@13K
GCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHHHHJIJJIJJJJJJIJJIJJJJJJJJJJJJJJIJJJJJJJJJJHHIIJJJJJJJJJJHIHHHHHHHFFFFFFEEEEEEDDDDDDDDBDC
@13L
CCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTT
+
@CCFFFFFHHHHHJJJJHIJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJIJIJJJJJJJJJJJHHHFFFFFEEEEEEEDDDDEEDDDDDDDDEEDEDDD
@13M
ATGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTT
+
@CCFFFDBFFFFFDIHEGGEEDGIIIIIGHGGBFDFGHGIIIIIIHEEFFFFFEFEDECCACDDDDDD3>@DBDDDCDCDDDDCDDDDCD@CDDDDDBBAD
@13N
CCTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJIJJJIJJJHHHFFFFEDEEEDD?@@BDDDDDDDDDDDDD
@13O
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
BCCFDDFFHHHHHJJHIJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJGIJHHHHHHFFDD@CCDDDDDEDCCDABDDDDDDCDE
@13P
CGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCC
+
@@@FFFFFHHHHHHIIIJJHIIIHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFDDDDDDDDDCDDEDDDDEDFDEDDDD
@13Q
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
CCCFFFFFHHGHHJJJJJJIJJJJJJJJJ?FHDHGIIHIIJHIJJJJJJJJJJIJIHHHFFFDEEDDDDDDDDCDDDDDDDCDDDDDDDDDCCCBDDDCDD
@13R
GTGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGCATAATTCCTTTCTCATAGT
+
@?@DDF@DHGHHGCGGEHIIFGEHEHCHGIIIGIIICHIGGHIIGGGHGIIIIIIIIDGIFHGGHIIIIIGIIIIIIIH@EHFHFFFBEFFCECEEECCA
@13S
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
@@@DFFDB>H?FBECFDGE?EGHIE2A?+9ACB3:?DC??8D08@F'.@FAF@F=@@D7:(;@BCC>BC:>C->;;A3:CC;<?ACCCCCCCC>CC@::::
@13T
GTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGC
+
BB@FFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJIIJGIIJJGIJHHHHHHHFFFFEEDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@13U
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGG
+
CCCFFFFFGHHHHJIJIIJIIJJGHIIJJJIJJJJJGJIIIJIIJJJIGIJJJJJGIIJJIGJFCAEFHFFFFFFEEEEECCEEEEDDDDDDCDEDDDBDD
@13V
ATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAAC
+
CCCFFFFFHHHHHJJJIIJIJJHIJJJJJJJJJJJFGGIIJIJBFHIHIHJGIHCEHGIEHHHHHFFFFDEEEEDDDDBDDDDDDDDDDDDDDDDDBBDDD
@13W
TTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGT
+
B@CDDDFFHHHHHJJJJJJHIJJJJJJJJIJJIJJCHIJJJJHIJJJJJIJJIJJJJJJJJJIJJIJJJIJJJIJHIIIJGIIIEHHHHHGFFFFEEEEEC
@13X
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGG
+
@@@FFFFFHHDFDBHHGGIJJJIIJIIIJJJIIJGIICHGIIJIIIGIIBDDDACDDAC>?CDDCDEDDCDACDD?DDDDBBDCDEDDDDCDCCCACDDCD
@13Y
GTCTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCA
+
CCCFFFFFHHHHFIJJIJJIIJJJJJJIJJJJJIJJJJJJJJJJIEGIIJIIJJJJJJJIJJJJJJIJIHIGIIIIJJJJHHHGHFFFFFFFEEDEEDDD
@13Z
AATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCCGCTTCACGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCC
+
?@<==44BFFB3CE<)<C?C?F?@EFED=3:9??B:*9BFFE8('-'5:<''3,,'(,9<@<;;0&55?>B?A1(++(4:>:40:(4(+(3>?B50<5344
@140
CCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTC
+
@CCFFBDFHBFFHGJIJJJJJJJJIGGIIIJIIIJJIJIIIIIJIJIJIJIJJIJJJGIJIIGIIJJJJIIHHHFHHFFFF:ACECCEDDDDDDDDDDDDE
@141
CTCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFDHHHHHJJJJJIHHIJJJJJJIJJJHHIJJJIJJJJJJJJJJJJJJJJJJJIJJGIHIHHHHHFFFFFFEECEEDCDDD8A@DCDDDDDD?DD
@142
TAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCC
+
CCCFFDFFHFFFHDGGHIIJJFHIFHGHIIIIJFIIJJHHIJJIIIJJJJJJIHHECDFFFFCEEECEDCDDDEEEEACDDDDCDDDDDDDDB?CDDDDDD
@143
CGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGT
+
CC@FFFFFHHHHHEGHGJJJJJJFIIIIJIIIJJJJJJIJIIJJIJJJIJIJJIJJIIGGIJJJJIJJHGGIGHEHGHFHEFFDDFDEDEEEDDCDDDDBD
@144
GGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGAC
+
??8ADD?DD;DCD+<<1:A4AF>CEEE2<EEAE>@?CD9<CD>BE>BDD*??<<=ACBB;C:=;=@;CE:ACCCC@=)7'95>??((>?A??,95:>3>>3
@145
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJIIJJJJJJJJJJJJJJHHHHFFFFEEEEEEEDDDDDBDDDDDDDDCDD
@146
CCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGT
+
@CCFFFDDDHDDDEHGIGIDHGHHH<DHHGII?DDCGIGHGHGGFIEHIGBHFHJDFH-=;DHEEEHBB5>CECCA@CC=?BB8@ACDCDDDD5>C@CDD<
@147
CCCCATACAATTTGATGACATGTGGGTGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGAGGCGTTCTCTTTCAGC
+
@@@DAD?DBCFHH<<EGIIGGGIG>GGHBCCDDFDHBDFBFFB@BDHIHIDGFCGFA=@EIIDC=6?=?DEC<>CCCC>C??:=55<?>598<@CC@CCCC
@148
CATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCC
+
@@CFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJIJJJFHIJIIJHHHFFFFFEDDDDDDEEDFDDDDDDDDDDDDDDDDEDEDD
@149
CTGCTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTT
+
C@@FFFFFHHGHHJJIHIJAFHCFHIJGHGI?EEHGJJJJJJJGGIGHIEGIJJIIIHGHHFFFFFEDEDBB>CDD@DDDDDC@>C>CCCDCCBBBDBCCD
@14A
TCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTC
+
@@@FFDFFFAFHFGGGIGIJFIJIJJ@HGIJIJJIJIIIIJIIJJIGJJFICHHHIIIJ=DEDCEDDEDDDBDDDCDCDDC@CDCCDBBBDBBCDDDDDCD
@14B
GTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCT
+
B@BFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJIJJJJIJJJJJIIGIJJHHHHFFFFDEDCEEEDDDCDDDDDDDDDDDDDDDDD
@14C
TCAGAAATCTGTCTATGAATGTTAGTCTGTTCTTTTGGATAGCATGAAGCTTTTACTTACTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGC
+
@@CFFDDD?FDHHIIIIIIIGCIDHHGIIEHIIIIIAFHGGBGIGEHIGEBBBAGD>D@<BFHIBBGIIHGH=@@=CEE>>C>;?CDDDCCCC>CEBB?A@
@14D
GGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCC
+
BC@FFFFDHHHHFGIJJJIJIIJJJGHJIGIFHGIJJJIIJJ??FHIJIIIIJJGIIJHIIIIHHGGHFHFFDFDDDDEEECEDDDDBDDDDDDDDEDDDD
@14E
CTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
?@@FFDEDFBBFD@HBFGDFGIIBCFHGBBHDDHGIIBFII0?@@FGGHHHI?BBBCCDFFHEHHGGGGFHHE@EFF>BFCEDEECEECCBD@?=BC>
@14F
TTGTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCAC
+
@@@D?DDDHHFFHIG@AE<CHHIIEHHIIIGIIHDADFHEGGIGIIIFIGHFFHEDEDD@CDE;>@=;?;B@?CC>C:>-9@B&5@BBBB?BBB9@BBBBB
@14G
GGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTT
+
@CCDFFFFHHHHHJJJJJJJIIJJIJIIHGHGIIJJJJHHHFFFFFEEEEEEEDACDDDDDDDDDBDDDCDDDBBD8?CBDDDDDDDDDDDDBD@DDDC@C
@14H
CTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGT
+
@@@DDFFFFFHFHIGIHHDHJGHGIGIGIGIIIGIIIBB?DEHGIIIJHGIIJIGHGHIIJIIIIIHEEDEEEFF(=@9?B@BDDDCACDDDDDDCABD0
@14I
TAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJIGJJJIIIJJIJIIJJJIIHHHGHHHFFFFFFFEECE
@14J
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCT
+
@@@DBDDD?FBDFEFHIH<?;AFEG<E9CDG@EEHEGHICCAFGB;??DE99BBBD<FH)==FBC)8F>GHHIECH>;);;?@7(33>?BBBBBCBBBCCC
@14K
CGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACG
+
CCCFFFFFHHHHHIIIIIJJJJJJJJJIGHHIHIJJHIIIJJJJJJJIIJJJJJIJJHHFFDEEEDDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCDDB
@14L
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTT
+
@@CFDDFFHHHHFCHIGIIIIJJJJJJICFGIHIIJDHHJFHIJGIJCHGHIGHJIJJHHGHFFFFFDD=BBDDDDDCDD>CCDDDDDDDDDDDDDDEDEE
@14M
CTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCT
+
@@@BDDDBHHHDHGGHGI@HBG?FHIIGCEEGGGHGHDCB*:?;1?F>F@HCEDHEGGG<CGGGHCG6@D>EEHDCC@B@DDC@CCCA@>A>3;(55>9:5
@14N
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCT
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJJJHIJJJJJIJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJHHHHHFFFFFFDDDDDDDDDDDDDDDDD
@14O
ATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGC
+
BCCFFDEFHHHGHJJJJIIGIJJJJJJJIJJJJJJJGG?DGIIJJJJJJJJJJIJJJJJGHIIJJJJJHGD@DDDEDDDDDDDEDDDDDDDDDDDDDDD
@14P
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCT
+
@CCFFFDFHHGGDIIDIIHJIHJIGIGIIJIJIGHJIGJJJIJIJJIGHGGIIJJJJHIGHIGJIIGEGGHGGEEFEHEDFFFEDDDDDBDDBD@B@B@CD
@14Q
AATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTG
+
@@@FFFFFHGFHHHGIGHIJJGG?GD@GIJGIJIIJFGHGIJIIIGIGG<G?FHIJJJJIFHBFHGGGGHIGIJJJIDHHGAEEFFFDFFFEACCCC:@C
@14R
TGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGG
+
CCCFFFDFHFFFHIJJJIJJJJJIIJIJJIJIHGHIGIJJHIJJJGEFFFFEE@CDDDDDDDDBDDDDDDD@CCDDDDDDDDDDDDDDDCCDDDDDDDDCB
@14S
GTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATC
+
CCCFFFDAHFDFFGHEGHGHIIJJIJFIGIECHIFIEIGGHBGHGICHIBFEGGIIJ>FGHGGGIIIJJGEECEHGDEFEDDDCDDDDDA91:@DDDCECC
@14T
GTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGAT
+
CCCFFFFFGHHHHJJJIIIJJJJJJJGHJJJJHHHHHFFFFACCEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBBDDDDDDDDDDDDDDDDDDDDD
@14U
CTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGC
+
@@CFFF@DHFHHHIJJJIJIJJIJJIIJIJIIJJJJGIIJIJIGHIHFDDDDDDDDDDDDDDDDD4@BDCCDDDDEDDDEDDDDDDDDDDDDDDDDDDDDD
@14V
CGCCATCTTCACCTTCAAAGCTTTCATTTATGACTCCACTGTTTTTTGCTTCATCTCTGGACTTATAAATGCTATTTAAGAAAAAAATTTCTGAATAACTG
+
?;;BD7B>?:CADD<EE:AC+<4<3<C9C992+9**1:)1::?*))8@B<8B<?/8=B4=<@@A;.).7;)=@).7?7=ACA>?(3>?>AAA,(,3,,>A:
@14W
GTAGAGAAGGATACGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATT
+
C@CFFFFFHHHHHJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHHHHHHHFFFFFFEDDDDDDDDDDDDDDDDDCEDEE
@14X
CGACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGA
+
CCCFFFFFHFHHHJJJJJJIJJJJIJJJJIIJJJJJJJJJIJIJJJJJJJJJJJJJJJJJIJJIJIIJJJIJJJGIJIJJIHHFHHFFFFFEEEEEEEDD
@14Y
GCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCT
+
C@CFFFFFHHGHGJJJJJIJJJJIJJJJJJIJJJJJJJIJFHIJJJIIIJJJJJIHJJFGIHHGHIIIJGIJHHGHHGFFDDBDDDDDDDDDDDDDDDDDD
@14Z
GGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGGCCTTGGGCCTCACAGG
+
?<?AB;BDA?D8:EE@1CDED>BADD6B@:DD6==BDD9;4.=@ACC9A>@97?;?A;>>;=1(59???=???>80;;>??AA?&55>AAA?>?>1+<>A?
@150
GCTGGGAGGAGGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCCCCCGCCATGAGCTCCAGCAGGATGAACCGGGGCAGGGAT
+
CCCFFFFFHHHHGIJJJJJJJIIJJJJIJJHDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@151
CTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACC
+
?@@DBDD?DHAA>GGBAEEDCHAFF;CBB;F@EGHB<GGC4?FGH?6BFBBF?FFHGGEHGACHHIAAG7CDHHEH?HE?B=ACF;>>>C@@C@;ACCCC
@152
GGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATT
+
??@ADADDAHCDDHGGEHGEGHHGFFCEHIIIEGHI@B@DHEGGGIE@CCCEHHBD>BC>B>>?A?A>CC?CCDDCDC4:A>C>CDDDCBBBD<ABBDBDD
@153
CCCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGCGGCGCCCCCAGCCCCCTGAAGCCCAGGTGAGGGCCGAAGCCGCCCATCCCCATCTTCATCCTC
+
?8?DDDDDDBFFAGGEF:ABAEFEFEFHE>EGABG;CFFFAE8AEEDDD?BCB;BBBA:????B(:@@805@9;955<>055539?BBB@@BBD>ABB>A
@154
GTCCTACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGAC
+
C@CFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJIJIJJJJJJFHHIJJJIJJJHHHHHHHFFFFFFFDDEDDDDDDDDDDDD
@155
CACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCAC
+
BCCFDFFFHHHHHJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJGHIHHIIJJJJJJJJJJJJIJIJJJJJHHGHFFFFEEEEEEEEDDDDEEDDDDDDED
@156
TGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCCFFFFFHHHHHJJIIJCHHFHJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJGIJJIJHHHHFDDDBDCDDDDDACDEEEEDCDDDCDDD
@157
CAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCTATTGTGTTTAT
+
@@@FDFFDB:7BBC>ABDDDDDDDCCCC?BCDCDDDDCDCDDDCB@BBBBDCCDCCC@CCDEDD@CDCD@CCDCDCDCBDDA>CBCCDD@CECCCDCCCD
@158
TTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGCTTCTGATCATAGGC
+
@@@DDFFFHHFHFIIIJGIJEHIJJHIJJJGIJJJJIJIIIAHIJCEFH=C6;DHGFDD5@BD>CDB>BDDDDEEDCABDCCCDDDDDDDD@CCDDCDDD
@159
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
C@CFFFFFGFHHHGEGIEHHIJJIJJIJJJIJIFHGIJJIJIIIJJJIDIJJJJIIIGHEEECEFF,9>?AACACCDB>??CCCDCDDDDDDDDBD@BDDD
@15A
AGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGG
+
@@CFDFFFHHHHHFHIHJJJJIIJCHHIJJJJIJJJJJJJJIGHIIJJIGIIJJJJJHHHHHHFFFFFFECCEEDEEEDDDDDDDDDDDDDDDDDDDDD
@15B
GCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGC
+
CCCFFFFFHHHHHJJJJJJJJJJFHJJJJJJJJJJJJJJJJJJJJIJJJIJJHHHIJIHIJJJJJJJJJCHHHHHFF;@CDDDDDDDD?BDDDDDDDDDDD
@15C
GCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGACCCCACAGAATTATTTTTCTGTC
+
@@@DAD8?DDAFFEG@EBB@CBEH+AHCCEBEFEEH?C@*CEH?DBB;;@GIEGIGIGIAGC?CG<8B<.8==FEG@GDGEEE:?@D@AC6>BDDCCCCDC
@15D
GCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGC
+
@@<DDDD?@CDFBGH>:?AFGB@FFHFGIIHGGHC@BBFGDH@HEHFHIIIIIIIEIHEAEHEECBB3;@2>CC@CABBBBBCCCCCA44>:>CBBB958?
@15E
GTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTGGTGGAAAATTGCAGGGAGGTGGGGTTTAATGCCATTTCTTTTGTTTAAGGC
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJIIJJIIJIIGIJJJJIJJIJ**?)))9B)?*****('-''-(5A'9'((6(((5((((((5>,(9A(>5(5(
@15F
GAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACC
+
CCCFFFFFHHHHHJHIJJJJIJJJJJJJJJIJJGIGIJJIEIJJJJJJJJHIIJIJJGIIIIJJGGFEHGHEFFFBEEBEEACCACDDDDDDDDDDFDDDD
@15G
TGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCT
+
@C@DFFFFHHHHHIJJIIJJIIHHEHIIJJJHIJ?CEEHIJJJIJIJJBGFFGIJ@DFHIGIIGHIGIJHCGGIIIJHHGGFFDBDDEEEEEEDDDDDDDC
@15H
CAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGG
+
CCCFFFFFHHHHHJJJJFHIJJJJJJJJJJJJJJJIJJJJJJJJJHIFGIIHHHHFFFDEEDEDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEEDD
@15I
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
CC@FFDFFFFHHHIJHIJJGIJHHIIJJIIIIIIDHIJJJJJJJGIDGGIJE@@EHEHHHHFFFEFCCCCADCCDCDCCCCC>CCDDDBDDDDEDDD>ACC
@15J
AGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGATTCTCCAGG
+
11:BD?D;CBD<BDGFIIIFH<IF<<CDG6FFEGEFBB:@DG0?<FFFF@FF@F;(.6;=@=;;A7AC:@BD@B@@>A????@ABB@BAB(5::A:>>3?
@15K
CCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAAT
+
@@CDFDEFAHBHFGHIBBHGHEDBFHIIGIIIGIGGIGGIIIGIGGHICHIIIIGGCGHGGIIEHG>FHIIGGGECAEFEHFE>>AA?-;>@@CCCACDDD
@15L
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGGAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@7<DDDADF:C:CFBG@B:F1<@EGDDE<?9<BF***:FF?G336?1CB3BC9ACFEFE=('6.77;B@B@B?;?2;3;A(555(;@>B?A:@A@3?9?B
@15M
ACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTC
+
???DDDDDBDDA:+A:E<:AEE@E4:?@EFEEDE>?ECB?*:*CBEEIE@B?DD<8??DEIIIED<=BDEEIIEICCDDD>?CDA>ADDD<AA@AAAD>>>
@15N
CATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACAT
+
<@@DDDDDDFHFHEEEGG<GAA@CGA@HEHBHEAGFGHGGIBF=BFHDBHHIIGDHHHA=AEDDFDCEEDCACCDADDDCCCC@@CD<CBBBB@DCCCB?@
@15O
TGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCAT
+
@@@FDFDFHHHHHIIDHIIIGIJIJJJIGIJIJJFHIJIIIJIDEGHIJJJJJJJIIJJJDHIIIIIHHHH?A?DEEDEEEEDCD@CCCECACDCCCDDED
@15P
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHGIJJJIIIJJIJIJJJFHHIJJJJJJJJJJJJJJJJJJJIJJJJJIIHHHHHFFF@CC@CEDDDD8?@5@@@@>CBDDDDDDDCACCCC
@15Q
GCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCG
+
@CCFFDABCDDHFEHBGEGBDHGFHI@HHI@HIHGHGHDHIGHIIIIGHIIIIIGGIGHGHGGEBDBDBCCCA@CCBCA?ABDB;@@ACACCDDDCDDDDB
@15R
CTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTG
+
@@@DADDFHDHH?HBHHEEHJIJJGJJJIJIGDHIIEBGI@FGHIGJ=CFHHGDHGID@HHDHHHCDC@DFD;@CBDDDDDDDDDD<CDDCDBDCCC>ADD
@15S
GTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGG
+
@=?ADDBDBCCDFB@11@F<CBG:?C:?F;G??0:BFC?D;;??;F5;@ADHHH;AHDEDDE@BCC?@BB,5<@CC::AC>CCCCECCCCBBBB9@?CCBB
@15T
CCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJHHJJIJJJJIJJJIIIIJJJJJJJJJJJJJJHHHHFFFFFEEEEEEEEDE
@15U
AAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTT
+
<@@FDDDFHGHFHGIGDBHHIGCFECDHIIGHHIJJJI@FGIEEFHHGCHH@D<?BFHHFFHGEHB;AEA>?BDFCF>CCC?@CCACCCCCACAAAC?C@@
@15V
CCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTTT
+
CCCFFFFFDHGFFIJJJJJJJJJIJJJICHIJJJIFHHIIIJJJIEGIIJIIIIHIJIIIJJJJJIJIJJJIEFGIIJHGGHFHHHGFFFFFEEDEEEEDD
@15W
AAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGA
+
@@@DDDDFHHFHGJFHGIGIHHHCIIC?EEHGGJJIIIFHJJIIJIGGHIIIIHGGFGIGIJIGHFHFEEFCEEECCCCADDDDDDCCCABDDBDDBDD?
@15X
TGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCT
+
@@@DBDD?BDBFDGB2<2CE6;EACEHGHIBA?EEEFCFDFHIGG<DDGEIBGD@ECGGG@FEHFC@G@@EICHFHFFC=B>?B@BBDCACCBB?CCCCC
@15Y
AGAGAAGTGAGTGTGCGACCGAGCTCAGGGCCCAGGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGT
+
CCCFFFFDHHHHHGGIIJJJIIBHIJJJIIFIIJIJIFIIJJJJJJIJIIHHHHHHFFFFFFDEEEED@CDDDEDDBDDDDDDCDBDCDDDDDBDDDBC
@15Z
GCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGAC
+
???DB?:,22CDD;EE:CA:+3C<C?2<2*:?9EEII;D;?:*9DD<9B98888B=8=C=7AD:).7@D777?DD>6.6@>@..655;,(((5,5>:
@160
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCC
+
CCCFFFFFHHHHHJJJJJJJHIJJJJJIJJJJJJJJJGHIJFHIIJJJIIJJIIHHHHFFFFFDEEEEDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDD
@161
CCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTT
+
CCCFFFFFGHFFHIJJIJJJJIJJIIIJIJJJIJGHIJIJIJJJJIJIIJIIJIJJJIJIIIJIJJJHJGI=DHICHHHHHHHFFFFFFEEEEDCEDD=AD
@162
CTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCT
+
@CCFFFFFHHHHHIHJJJJJJJJJJJJIIIJJJJFIJHIIJJJJJJJJJJJJJJHIIGIIGJJJJHHHHHFFFDDAACCDDDDDDDDDDDDDDDDDADDDE
@163
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@@@DBBDBHFHFHGG<FGHGBG@CEGHII<EGGIBBD??B>?F?@<?F@>FFB@F.=CDDA:FEHG@;EHGI;EHEECBBDA=?5;55;>CB<<@A@@CCC
@164
TATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@@@DDDDD=+<C;BGBDFG>F>FBHGGGEH??CFHEFDG9?F6@GGGIIIIGH@DGEHEF7;;@;@AA>C>C?AB(;>C35@CCC:@CC>43>ABC@BCC
@165
CTCGTATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCCGAGGAGGGGGAAAGCTTTGGCTGGCCGC
+
??7D==2AC?DDDA3+A+CEEE9F?BC<1)1:C***1?DDEE*0?DD;B*0**?<;DD23B:)=ACAAD;C:):14<@>?>??;;88>(+:>>AA<;<8&&
@166
TGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCC
+
@@@DDDDDFHFH>GGGGGIIIIIG@FHECHHIBGGFH?BGGGEHE>FHGFGG?BCE8BFH5=DHCHEFABE;?CCCCCCCCCB@<BBCCCBBB>>BCCCC<
@167
ATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTG
+
;@@FFDDDHFHFFIIGGGHJIHEGHEFEGCHHGGHGIIIGIJJGGIFEEH?GBFGHDFGHGGGGGIJGEHIIIJJCEHF>EAHCBD@@CEECEEEDDDDDD
@168
CTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTT
+
@@@DDFFFHHFDHGHIJJIIJJJJGJIGEHHIHHGIGGDFHIJJDHIIB?F@BHGG>EGI>ECAGIIGIIGCGGGHGCHFBCE7A@?CDDCEEEACEEECC
@169
CTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACT
+
@@@ADDFFDD<FFDFHIFCHGDCHIIIIICDF@CHIIIGHIGHIGCEHGGIIIGIIGIBHEEA=CEHFDCEFBABDDCCAC@CACBDDC@ADBBBDDDDDC
@16A
GTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACT
+
CCCFFFFFHHHHHHHHJJJJJJJJJJGHIIJJJJJJJJJJJJJJJJJIJJJJJIJFHGHHGIJIJJJJIJHH?EHFFFFD=ABDCDDDDDD?BDDDDDDDD
@16B
CTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJHHJJJIJJJJJJJJJJJJJIIJJJIJJJHHHHHHHFFFFFFFFEEEEEDDDFDD
@16C
GCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGT
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJIJJJJJJJJJIJJJJJJIJJJHHHHHFFFFFFEDDDDDDDDD
@16D
CCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTC
+
@@@DDD?DFAF<D@EHIGIIDIIEGHIGGHGA:@6?DEG@FGGGAGHGIIIIGGFAACHEE@<>B>A@?8?ACCCCCCBAACCCB<<@?CCCCB<?CCB>9
@16E
CCTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGAC
+
CCCFFFFFHHHGHIIHGJGGIIJJEHGIJJJJJGIIJGIJEGDHIIIIJJIJJIGCH@EGIJHHHFFDDDDDDDCCDDDDDDDDDDDBACDBDCCDDDD
@16F
GTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTC
+
@@@DDDDDAHHFFGBGGII<?FDDHIIEGFEFHGHHHGCDGIAGIIIGIHIIHAHEECCCCCCCCBC>CCDECCCCCC@CD>@A988><A@BBB?CACECA
@16G
CCCATGCAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAA
+
CCCFFFFFHHHHHJJIJJJJJJJJIJJJIHHHIJJJJJIJJIIJIJIIJGHIGIIJJIJJJJJJJJJJJJJJJIJJJJHHHHFFFFFEEEEEEDDDDDDD
@16H
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHHHHHJJHIIIIJJIJJJJHIJJJJJJJJIJFHJJJJIGIJJIFFDEEEEDDDDDDDDDDDDDDDDDDDEDDDDDCDDDDDDEDDDDCAC
@16I
CTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCA
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJIJJJJJJJJJIJJJIJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJIJJJIIJGJJIHHHHHFFBDFEEE
@16J
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
CC@FFFDEFFFHHJIIIJJIJJJHHIIDGIG?FGHDFHDFIG?DHIGGGGJJIIIIGIIJJFEH9BFFCEEDEDD@CDDDDDDDDDDDCDDCDDEEECDDD
@16K
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFDFHFHFHIJJJHHGIJJJIJIJIIJJJJJJJJIJIIJGIGIJIGIGIGIGGIHHHHHFFF9>B;CCDDCDBDBDDCCCDDDCCDDDDDDDBDDBC
@16L
TAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGAT
+
CCCFFDFFHHHHHJJJJJJJJIIIJIIJIIJJJDFG@DFIFHIJIJJJCGIJJJJGIJJJCEHFFFCEEEEECCDDDDDDDDDDDDDDDDEEDCBDEDDDD
@16M
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJHHGHFFFFFFEEEEEEEDDDD3=BDBDDDEDDCDD
@16N
CTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTT
+
CCCFFFFFHHHHHJJIIIJJJJJJJJJJJIJJJJJJJJHJJJJIJJJJJJJJJHHHHFFFFFFEEEEECDDDDDDDDDDDDDDDDDDDDDDDDDDDEDCDD
@16O
CGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGT
+
@CCFAD>DH;FHCEDHIGHAFHGGIIGFGGGIDECGIIHGFEAHBD>8ACCACCCCCCCDCCCC58@CCACCCDC@CCCCCCCCC@?CB<ABC>ABB5<B+
@16P
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGT
+
<@@1BBDDDF>F>BFFA?;<+<FFEFIE8@B@G3?FDE>FCBGBAFFD@99?(B;6BB;@F)=@).=CE:7?)=.7);7?D@@@BC>>((55>@,5,:A@>
@16Q
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGT
+
@BBFFFFFHHHHHJJJJJIIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJDDDDDDDDDDCCDCDEEEDDDD@CDDBDDDDDBDDDEDDDDDDC
@16R
CGCTTAACTATCAAACGTGTCCATTAATTTTGCCGCTGAGGGTGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGGAAACCCAGTGTT
+
CCCFFFFFHHHHHJJJJFHHGIJJJJJJJIJJGIJIJJJJJJDGIJJJJJIIJJJIJIJJJJJJJJIIHGHHHHFFFFFFEECEFEEDDDDDDDDCCEE
@16S
CTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
CCCFFFFFHHHHGJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHEDEECEEDDDDDDDDDDDDDDDDDD@BDDDDDDDDDDD
@16T
AGTCTCTCCTAGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGC
+
@@@FFFFFHHGHFGHGGEEHEHGIGGIIGGGGEIGDHBGGIJGEI@FHGEHCGIHIJJFIJ4A?=CECCACBDBDBDDC>ACCC@CACBB>BD?BC>?>CC
@16U
CATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATT
+
@@@FBDDDHHHFHJGIJGIIIIIIJJIIJJCHHJIGGIJIIG:CFHIIHJJIIIJFHGIJGHIJJIJJJJIIIIGGIGGIIGAGIJHFHECCHHFFDCFF
@16V
TGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTT
+
;;?DDDDA>FF>F:C<FGI<:A<EHEAEEE8FDHEFF???4B9DEE?BDGGDHGG<@BCHG@=C=@4.).7A>?>).;?7ACCBCCC5>@;<ACCB?B>0:
@16W
CATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATG
+
??7BADDDD8@@@E:ACEFDC;CEECE9@DCDDIDEEE9DDIIBDDIIIDEE9BBC>CEIACDCCCDCD@ADDD@AA@@AA;>>BAAAA?A??5;??8A>>
@16X
CTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGC
+
???D1:B?<,22+<2?BECADE@+<?E+++22C*?*?EAD>?D9DDAA)B8===)/)=A;4==?7?A?1?A>;>;((6>>2::5;>>A(:>AA>>>(4((
@16Y
AGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGAAGTG
+
?@@D=DDDHHHHABAEFEHIGGHGGGCHGDHIIGGGGGIFFGGHIDFHEGIIIGIJJ7;AH9?A9ACCC>CDB8?BD@CDCCCD8<?B<?B?CCBBBBD>@
@16Z
GCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGC
+
CCCFFFFFGHHHHJIIJJIGIJGHIJJJJJGHIJJIJJJJJJJJJJJJIJJJJJJJJJJJFHGIJJJIIIJJIHHHHHHFFFFFFEEEDD?BDDDCDCDD
@170
AGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGT
+
@CCFFFFFHHHHHJJJJJJJJJJJIJJJJIJIJJIFGGIJIJIJJJJJJJJJIJJJJJHH?DDFFEEDDDDDDDDDDCDDDEDDDCDDBDDBDEDEDDDDB
@171
TGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGG
+
?@;DBBA?AFDHAFGIGCFFHHIHHHIIB?C@C>D9EGC<F3<DGGEHGB>@B=BBGDEGGFD8C>EGDHF3?77=?DD@DDBEE;><BBBB<C>@C5:<
@172
AATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJIJJJJJJJJIIHIHIJJJJIJGIJGGIJIJJJJJJJJIJJIJJIJIJJJIFHHGGHFFFFFFEDDEEEEDDE
@173
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@@@DDD<:CBFHHB>9FEEGIECFH<FCFG<EEH8??BB@EHCHIGEGGH@3=CFGBGD8@EEHI7DAA=A=?B@@>CD@@A>3>?=,8255:>:::AC
@174
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGT
+
BCCFDEDFHHHHHJJIJIJJJFHHIHGII?FHIHJJJGIJDHHIJGIIIJIJIIJIIJJJJJHHFEFFFFDDD>@CDDDDDDDDDDDDDDEDDDEDDDDDC
@175
CTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
@C@FFFFDHFHHGJIJJJJIJJJJIJIIJIIJEGGIGIGIIHGIJGIIJEHHEFAEHDFDDBCDD@CCDCCCDDDDDDCCCC@CCCDDDDCDCCCDDDCD
@176
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGAC
+
CCCFFFFFHHHHHHIJJJJJIJJJIIJJJJJGIJJGHGGHGGHJJJJJJJJJJJIIJJIIGIGJIIJJJHFGFF>CD@CDEDDDDDDDDDDDDDDDDBCD
@177
CCGGGTCAGTAGTTGCCGTGGTGACACTGGAGGTAGGTGGTCCAGGTTGGGGGGCACTCAGGACACAGGGCTGGGGGGGTGTCCCCGAGGGGGGATCCAGG
+
@C@FFDDDHHHHHGGIGJIEHACFGHFHIJDD;BDDF?FFFHIJJJFGGHGEA8B5??CDCACB?BCDBDBDBDDDDDD)95@CDDD@BDDDDDDB@CC><
@178
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@@@DDBDDFFF?33<<@@8@FHD2<CGCCEFE<@BFGEAF@36DF@FIE@B=CFFEFFEFE)7A7AABDD@B;=A@;AB@@3@;@BB9555,5:?>3>44>
@179
GCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTG
+
CCCFFFFFHGGHHJJJJJJJJJIJJJJJJJJJJGIHIJJJJIJJIJJJJJJJIFGHIJJJJJJJJHHGIJJJHHHHHGFFFFFDDEEEDDDBDDEDEDDDD
@17A
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJDDDDDDDDDDDDDDEEEEDDDDCDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDCCDD
@17B
GTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGG
+
CCCFFFFFHHHHHJJJGHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHFFDDDDDDDDDDDDDDDEEDDDDDDDDDDDDDDDD@BDDDDDDDDDDDDDD
@17C
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@@@DDFFFDHF?FEEHII3@@?CFD@FEEGGBGADGCHGGFHIEHGCE<>>EHHGFHHFBEFEDCCAA@CA;>ACCCCCACCDCCCCCACCBB@BBCCCCC
@17D
CAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGT
+
CCCFFFFFHHHHHJJIJJIJIJJHGIJJJJJIJJJHIJJJJJJJIIJIJIGIJJJHHHGHFFFFFDDEEFEEDDDDDDDDDDDDDCCDDDDDDDBDDDDD:
@17E
GCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTC
+
@@@;BDD@DDFF>FEBE<HHAFFEF<EAEE?E9CFBDDBGCAFH>F@D(?66CGICC7=CA=?EDCB=6589:>4@CDCCA?8<@@BB?C:89@CCCCCC@
@17F
AGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCCTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGAT
+
<@@DADADFFA?3EFGHGGCFB<EHGAGHIIIII3DGHEBGGGICF>GCH7=7CGEG@@:.7?CEE>EEEE:@>>6>?B?>@>@CC>>B?::>?@@785<B
@17G
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGAT
+
C@CFFFDFHHHGHEB>FHIIIII<CFHGIIGGHIIGIIG@GGGIIIIGIGIIIBEHGDDF@DECAA@CCC=5@A;;AC;,::@CC>CCACCBCCC((:ACC
@17H
GGCATAGTTCAGGCCTTCAGGCTTGCCAGAAGGGCAGTAAGCCACTTGTTTTTCTTGGCAGAAATCTTTGTCTGCATGTGGTTCCTTCTCTCCTTTCCTC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJIIJJJIJJJJJJJJJJJJJJIJJJJJJJJIHHHEHHHFFFFFFDEDEEEDDDDDDDDDDDDDD
@17I
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
=1?AB?@+A<DA<GAGBBFB<FFEFHCBGEEC<?GECFFG;DDC*BF9B>?FAEFI@.=F@AF<@A<<3>AB@;;--5=?8??9<?:4:88>3(4:+4?BB
@17J
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
@CCFFDDDFHFDFIJGBGHIGHCHGGIIIJHIJIIIJIIIGJGCGGCGGIIGEGIIIHIJDHAEDGHHGGHGDFFFDEED>CBD5>@BACCDDDD+8ACDD
@17K
GTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTC
+
;@@DFFFFHFFHHIABBBBGHGHCHGIICH@BFIIB@FGFGGD@FFF:F@F@@CCGEHEGEHFEEDEFDCCB@>@@@@BCDCCCB?ACCC>@C9>>:B@@A
@17L
GGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTT
+
BCBFFFBDHHFHHJIJJFHIIJIJJJJJJIJJJJIJJJJFHIJJJJJJJJHIJJJJJJHEHHFFFFFFFEEEEEEEDDDDDEDDDEEDDDDDDDDDDDDCD
@17M
TTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
CCCFFFFFHHHHGJJJJJJIJJJJJFHIIHHIJJIIHIJJHIJJJJJJJIJJHHHHHHFFFFFDEEDEEDDDDDDDEDDDDDDDDDDDDEDDDDDDDDDDB
@17N
CACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGC
+
?;?D;?BDB?ACA;;:<AFCB?ACGGFEHB9???FB99?GH@D?BFBGBB;FCCG@37=@7=@==??;?>BCBDE?>6;;;AB;;55>C@>9>:5,+<?
@17O
TCACCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGT
+
@@?DDDFDHGHHFIEHEFGHGGICHGIIIIIIGGGGGIIIICGIGGGHIEGGHIHIIIGIIIIIHFFHIIAHE@CHEHHEEFEFFFFFFEDB>CA.;@CCE
@17P
CTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTC
+
@@@DDDDDHB?DBFGG>F@<HDHDHIIIGIIEBGDHIDGGIBDDGBBHG<FFDF=FHGI;FGIIG>EHHFEEEEEEB@B@=@CCB<?>B?CCCC@C3>>>C
@17Q
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
CCCFFFFFHHHFHJJJJJJJJJJJJJIGJJJJJHIJJJJJJFHIJJJJJJJJJJJJJIJJJIJIJJJJJJJ=BHDEFFEEDEEEEEEEDDDDCDDDDDDDD
@17R
AAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCCTGTTGGAGAGAGCATGAGGCAGAA
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJIJJJIJJHHHHHFFFFEEDEEDDDDDDDDDDDDDDDD
@17S
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
;1?DDADD?FA<DHH<EHGADE>GBBGE?F@DGGD;DHDDGCA8BBFGBGA=AB=@2@=CEDGC@D>AE>=7;7?>@A@@C>@>>CBBB>@@B9;9@7<0?
@17T
GCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGT
+
?8;BDDDDBDF<FAGHDHDHHHGHIIG@DHIE=EE@?@BGFA@F?BFGGGIG?<BGG@BF=@GIA;D@EE>AH>;;@;;CCCACCC;3;@CCECB?BB?:
@17U
GCATTTTTGGTATATTAATCAAATGTGTCAGTTTCTTTATGTTATAACATGTCTGAGTGTCCTAATTAAAATCTATTAAACTAACCTCTTCAGGCTCAATC
+
CCCFDFEFDHHDFGHIIIIJIGIJJAHHE@HHEEGGIJIJJDFIHIJIGHIJJJJJI?DBDDGIAHIEFHIGJIIJGIIIICACCACCHHECFFFFEECEE
@17V
GTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTC
+
CBCFFFFFHHHHHIJJJJJJJJJJJIJJJJIJJJJJJFHIJJJJIJJJJJJJJJJJJJJJJJJJJJIJJJJJJHHHHHFFFFEEEEEEDDDDDDCDDDDDD
@17W
GCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCA
+
?<?B:D;DBCB?AAE<E<,AA<A?+AFFF?FA?CB*@E<DDC:9<:9B*:90?9DDDBD><))=B@@AC6@CD@AC>A?==>;<>;>A@AADD>>B:;>5
@17X
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
@@@ADDDAFHHFDEHGHGHCEEFHHJJJGGDGIIIEEHGBFIIGCD;CFE>G=EGEEEH?HEDDDFD6>@@CCCAADDDCA@;::9@AB<CCD>CCC(>:>
@17Y
CCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGG
+
@@CFDDDFFBFAHIIIIGHIIIIGGEHJFGHGHGIJEGI<DGGGGIFGGHIIIIICHHHEFHFDFFECCDCEDDBB?CCDD:ACDDA99595@CCC@ABD
@17Z
CAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCC
+
=;@=BBBDFFDDF;AF4CCGGIB@19+?G:CGC@@????DF<?BA3BFFII>BF>FFEF.8@@EI4CEEF>E:?88>3;=75;=B8?<>4@??BBBB4832
@180
AGCAGCTTGCAGCCCTCTCTCAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGAAAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGA
+
CCCFFFFFHGHHHJJJIJJJGIIJIGHGJJJJJJJJJJIGIGGHIIIIHIJGIIJJJJJHHHHHFFFFEEACCCDDDDDDDDDDDDDDDDDDDDDBDDDD
@181
CGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCATT
+
<<@?DDDA?FFBD@ACBGAHHHGGGGCEGGGGG>BH<?FHIIBGEE:?B<<FDHHG:F8??FA;;BCEE;AB<>ACCACAC(<=8'8<?C>>::>CC9C3(
@182
CCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCAC
+
@@@DA=A=CAFDDHIIEGBFEHHIIII@HGGCGCFGGDHGGIGIEGIGIIGHHIBDCGCHICFGDGGEDIIIIIIHHHHFHEEE@ACCCCCCCCCBCACCC
@183
CCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATAC
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJDHHHHHHHHHFFFFFFEEEEDDDDDDDDDDDDDDDDDDD
@184
CTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAAC
+
=@?D=:DBFDF?F?EEGEGEGECC9AGH>FGGHEDGE9DGIFIG3/0?6CE28=FH7@CHG=CAE@E</9ABBBBBB?@=@BB&39@?12?CCC3:@??C
@185
CCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCT
+
CCCFFFFFHHHHGJJJHIIIJIGIJJJJJJHHDHHGGIJIJJIJJJJJJIJHJJJJIJJIJJJIJIIJJJJJJJJHHEEHHFFFDDDECDDDDDDCDDDDE
@186
TGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTG
+
BCCFFFFFHHHHHJIJJJJJJJJJJIIIJJJJIJJJJFHIIJIHHJIJJJJJJJIJJJCHHHHHHHFFFBDEECEEDDDDDDDDFDDDCDDDDEDDDDDDC
@187
AGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGG
+
?BCADEDFHGFFGIIJIIIDIGJIBHJJJIIIJEGICFHGGHGIIJJJJJJJIIHGHFIBEIEHJD;?;ADCDACDD:@@CCDDDDDDCDBDDBDDDDDDD
@188
CGTTAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGGGCTGTGCGGGATAGG
+
@@@FFDEF?HD;?@A@<A@HBGHIIGIFAHGIEA@?6=B6&6?>C@CACCCC85<7@BCCCA?@B??B:AC>@??-2<@BBBBCCCB?A>BCCB<B95?A?
@189
GCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACAT
+
@@@DABDFFDDHHGHDGEGGGHGE<BEHEHHIGIIFIEG;DDGGGGEEGHBHGIIII9<C<F<CHGEGEGHHEHGEGHHEEF@DFDFCDDCE>ACCDD?CC
@18A
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
<??DDDDDADDHDIFHIGEDBBEF@GHGIGFHIEADGDEFHEHGEGGGDHGGBFHGGGCHCDDC@@;C.7=@@DDDECCCEC?BB,8=>9>?CDCA4>A?
@18B
CCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCC
+
?7;DDDDBFDFBFFIBA<?:+<+A3CFH@442<FF<<?C9?99?4D499?D@BF;FD?DB@89BFC@=(/=@>7).@;@E;.@4=;?EEFEDD@7;@>3;
@18C
GGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGG
+
??<BDAAA?DFHHB>E?FHI@HDD?A9C@@AFB?4C6F=FBGC9??@FC6B==CDF>F@=@7=D)5;5;@B;@;7>;@@A;;(>;A@>:?5>?<@?8?CB8
@18D
CACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGG
+
CCCFFFFFHHHHHJIJIGIIJJJJGJIIIIIIJJJJJJJJJJJJIIJJJIJJJJBABHHHHHFFFFEEEDDDDDBDDDDEDDDDDDDDEDDDDDDCCDDD
@18E
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@CCFFFDFHHHHGJJJIJJJEHIIJEHIJCGHJJGGGHHIIIGGIGGGGIGIJJGJJJIIIGFEEFFFFFDDEBBBCCCDDDDDEDACDDDDCDDDDDCC
@18F
CTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTG
+
CCCFFFFFHHHHHJJJJJJJJHJJGGGJGGIIJIGHIIIJI@GHJHIJJJGH@FHIIHFHFFFFEDEDEDDDDDDDCDDDDDDDDCDDDDDDEDDDDDDDD
@18G
GGGGTAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
1???ADA+CBACD<CEEBEEIBEEFC@E;@=1C=8CDDEE<DDDAB?DBD?DDED>AAAADD:;?;?@@>(.;>;>5>A5>><:AA>A9?>?A>A:::>A<
@18H
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCT
+
@@@FFDFDFDHHFHJIIJGG@GIIHGIIIHGIGCCGIJJIHIIJGGIIJIIBDBCFGIIGDGHIJJHIGIHH?EDD,>?B@ACB?B?59A@CDDCDCCBB?
@18I
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHHHHIJJJJJDIIIJJJGIIIJJJJJJJDGGJJJJJJJJJJJJJGHAHHFFDDDDDDDDDDDCDDCDDDDDDDDDDDDDABDDDDDDDDDDD
@18J
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
CCCFFFFFFHFHHJHHHIJI?FHIJJJJJJJJJIJHHHHFFDDEDEEDDDDDDDCDCDCDDDDDDCDDDDDDDDDDBDDDDCDDDDDDDDDDDDDDDDDD
@18K
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATC
+
@C@FFFFFHHHHHJAEGIFHIIAFHIIGIJIJJFHGIJFHEHGJJJIJIIIIJJJ;AHIHFGHGFFDDFEEEEDBBBDDDCDABCDDEDDDDDDDDDEDDD
@18L
CCGCCTACTGGCTACGACGTCGTTTCTTCCTTCTGCCCGTGACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGGCGAACTACTCCCAGAGCTAGG
+
@@:BDDDDDHBFBEGHIIIHDHGICEGEHIIIIIGCH@D@FEFCCHHG;GCHGEH@=?DCCCCCAC=@BB=AAACDCCC&5><B>?CCCCCCC@BB>C>>A
@18M
TGGCATCCTACTCCACGCTCAAAAGTGGCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCA
+
@@CFFFFFHHHHHJJGIIIIIJJJJFHIIIIIHIJJIJJJIJGIJIJHI9BF3BFHGIHGIGIJIJJJIJHHHFCDFFFFDCCDDD8?B;CDEDDDDDDD
@18N
GGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGGTAT
+
@@<DFFFFFDFGHIJGEIGEHDGGIJJGABBDF@CAAEB?BDD3;?CDCACCB<8CCDDDAACCDCDDAB?@B09<CC@BBDCCDDDDD(:?B8?BD&5<C
@18O
GTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATG
+
@BBFFFFFHHHHHJJIJJJIJJJIGHIJJGHIJJIJJJJJIIIJJJJJHGHJJJJJIGGIHJIJJGIJJJJHHHHHHFFFBCDCEEEDBDDEDDDDDDDDD
@18P
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@C?DFFFDAFFFDBHHIFCBHIIIGHHEIIIEHIIGIIEICGEFHHIGGDFDGIH=AEFFF7;@@>C;3;@A>ADD?ACDDCCCDCCCCC@D<AADAB2>@
@18Q
GTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGG
+
C@CFFFFFHHHHHDDDDDDDDDDCDDEEEEEDDDDDCDDBDDDDDDDDDEDDDDDDDDDDDEDDDDDD@DDDDDDDDDDDCDCBDD@CDCCCDCDCDCDDD
@18R
CTCTGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@@FFFFDHDFDHIJIGGAFGGGIGCEGGGIHJIGHGGIJGHGGGHDGBHBDHJJIEGIHGIIHHH'009@DDDDDDDBDDDDDCCDDDDCCCBDDB@DD@
@18S
CGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGC
+
CCCFFFFFGHHHHIJJIJJJIGIGIJJJJJJJJJJJEFHJJJJIJDHGIIJJIIIIJJIJCHIEEICGHHHGGEHFFFFFFFD;ABDDDBDDDDEDCDDDD
@18T
GTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCC
+
;@@D?DDAFDDDB>;AAGBBHEGH>??C8C@@@DHFE;@A?CAHHE=?BABCCB@?==?:;CCC:?ACAC@::>:AAAC:44:>CCC@>9(<?B9CCCAC>
@18U
TGAACCTTTCTGCCATCTCATAAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAG
+
@CCFFFFFHHGAHGIIEGHIIJJIIEGIGHIJJJIHIHEIGDFFGHGI9B@BFGIJJIJJJJJGHIIJHHHHFFFFFEDEEDDDDDDDDDDDDACDDED
@18V
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
?@?DDFFDHHGHHGIJGDGHIII?EAGHGGIIIJJJEHJIFAFEDGGI6=CEDGGGGIGDEEEEEDDFB;B?>;?;@ABBDDDDDCDDBDCDCCCDDDDBD
@18W
GATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGC
+
CCCFFFFFDHHHHIGIHIHGDGIGJJEIJIBHIIJJGGCHIHGIIIIJIHJJEI8FCGCFCFGIGIJDGFHHFGFCEF@CE;AEDCC?BACCDDDFDDCDC
@18X
CTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTT
+
@B@FFFFFHHHHHJJJIJJJJHHIIJJJJJJJJJJJJJJJJJIJIJJJJIJJJJJIHIIJJJJJIIJJIJJIJIIHGIHHGHHHHFFFFFFEEEEEE>ACD
@18Y
CTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTG
+
@@@DD:B?F>FBFGII<EG@GIBDH9FFE9?ABFFEFECCDGEF<BBDDFCGDFFD>FFFI8'5=CE1;BD9;6>A@>BBBBB:9>:::5>ABB<BBBB3
@18Z
CAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGT
+
@?@DDBA>F??CDAHGHEHGCHGGDBFG;@@@FHI8=AEHDEEBEECCC6>ACCCCCB=?=AB652<@&0;88><CC><?@C<@???B>>B@CCCCCA?9+
@190
CCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATC
+
@@@FDFFDFFFHDHGIGDHHEFGIIICGIGDFHEHEHEIICGBDHIGICHIIIIGHEGIIIIIIIIIIGGHGGGIIGICHEF@EEDFBEDCEECCECC@AC
@191
CCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAA
+
@@@DDFFFDDHFHIJJGIIHIJGIIGEGGFHGEHIIGGGGIICGHJIIHIJIIIIJJJJIGHIIIJIJIIIIGHEEAEHFFHFFFFFDEECCDDDDDDD
@192
CAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJHIIIIHIGIJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEDDEDDDDDDDDDDDDD
@193
CCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
CCCFFFFFHHHHHJJJJJGHJJJJJIIIJJJIJJJJJIJJJJJFHGJJJHHIJJJJJJJIIHHHHHHHFFFFEEEEEEDDDDDDDDDDCCDDDDDDDD>CC
@194
CTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATCTTGCTTTGGGAGTCCCATTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGG
+
@@@DD>DDDDD8D>FAFHEC=E@G;CCC@FGGG>3:*:??<@F?*968)?*9?F)8BCDC3=87.77CAE:)==AC@>B37>D>>(.6;=;??CCCBBA9C
@195
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGT
+
@@@:D?BBFBFFDD9CC<E??EE;GHEBFCCF?D<FGDHIEFGCEFBFGBFEH;;DEHFAEFCD7?CD@CACCCC>C->;>C?BB<@A5>@CCCCCC3@C(
@196
GTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGG
+
CCCFFFFFHGHHHFHHHIGHIIJJJJJIBFGIIIJJGGHGHJIIGGCGIIJJJJIJIHHD>ADDBD?@>BBBD9@BBDACDCCDCDCDDDDBDDDDD99BB
@197
CACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACG
+
CCCFFFFFHHHHHIJJJJJJIJJJJJJJJJJJJJIJGHJIJJJJJHHIJJJJJJJJJJIJJIGIJIJJHHHHFBCDBDDEDDDDDDDDDEDDDDDDDDDDB
@198
CCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJAFHHHIJEHIIJJIIJJJIJHFHIIIJJJJJJFACDDEDDDDDDCFDDDDDDDDDCBDDDDDDDDDDDDDDD
@199
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
CC@FFFFFHHHFHCFHGIIIIIJHIGJJJJIIJJJHGGIIIIIGIIJIIJIIIJJGIJIHIGGJJJG(=EBDFFEECDABDDDCCDDDCDB?BDDDDBDD@
@19A
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJIJJJJJIJJGIJJHHHHHHHFFFFFFEEEDEEEDDDDDDDDDDD@
@19B
GCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGC
+
CCCFFFFFHGHGHHIIIJ<CCDHGIIIGHIIGIIIIIIIJJIJIJIGIJJJJEIIIIJJJJHHGHHFFFFDCDDDBDBCDEDDBDDBBBBDCDDCCDCDDC
@19C
CATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCG
+
CCCFFFFFHHHHHJJIJJJGHIJJJHJJJIJJJIJIHHGIFHIIIJIJJJJJJJJJHHHHFFFDDDDDDDDDDDBDDD@CBDDCDDDDEEEDDDDDDCCDD
@19D
GGCGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTT
+
CCCFFFFFHHHHGEGHJJIIJEHIJJJJIIGIIJJJJJJJJIFHIHHHHHFFFFFFEDDDDDDDDDDDBDDBCDDCCDDED:ACDDDDDDDDDDDDDDBDD
@19E
GTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAAC
+
CCCFFFFFHHHHHJIJJJJJJHJIJIJIIJJJJJIJJFJIIIIJJJJJJJJJJJJHHHHHFDDDDDDDDDDDDEEDDDDCDDBDDDDDDDDDDDCCDDCCD
@19F
TTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCT
+
C@@FDFFFFDDBBFHJJIJGEGIEGHFGHHHIJJGIIGHJJEBGIJGIHIHJBHGGGHIEGHGIJJGBFGIGEGIGGHHEHHHHHFFFFFEECECCCCCDD
@19G
GGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTG
+
??@DBDDEHGHFHIIJIIIEGGGIIJIJIJGGIJEGIJFFGGHGIGGIHIIGIJGCFGICGIJAHCG@EEEFHHF@@BDDEECDBDCDBBBACCCBDDCCC
@19H
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGT
+
@?@FDFFDDHFHFJIIGJJIIIIGCHFGDEHGEAGGHGGGIJIIHHCHIHIIJGIIGD@BBACCDCD>CCDDDEDCDCDCCDDBB@@BDD@CCDCDD@AC>
@19I
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTC
+
@@@FFFFFDDHDBFGGAEG@FGEHGEFHGGHIDGHFFIIGGGFEHE@FGFGCGHDDBDBBDBDDCCCDCCCCDDD<<55>CCDDD>?>BAAC4@B::>CD@
@19J
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
CCCFFFFFHGHHHJJJJJHJJJJHIJJHIIJJGIJJJIJJJJJJJJJIJJJIJJJJIIJJIGHHHHHFFFEEED@CDDDDDCDDEDDDDDDDCDDDDDDDD
@19K
GGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGC
+
CCCFFFFFHHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJBGIIIIIGIJJJJJJJJJJJJGGIJIJHHHHFD@DBDEDDDDDDDEDDDDDDDDDDDD
@19L
GGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACC
+
@@@FB@DDF@BCDHADGI<HGFHHFGCFBFDHFFA@<DBBGDFH?B<D8?;=@DECE;FCGAGE>?DE;@DDC<>@9?BB>9-<9@C<CC49A:>@DD@:
@19M
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@=@BDDADDHBBFEHIGIIIIIIDFBH?FEDEGEFHHCGGG0BF?FCEDFHGEGGIIGH>A@@8CEEFHGDDF;CAEE>AC>;@CC?CAAB:>?BDDDDCC
@19N
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGCGCTTGGCTGTAGGATCCCGTTTGGGGTGGGTAACTAGTGGGAGGC
+
??1=D1AD?D8<<AC<EBF:+3<C681??911:C*?4:?0?30BD*B9DD8??BC)-;;AC77?C2?;??)).((6(;>7;?;,9-9A34+(4(:282<>(
@19O
CCCCTTTTTGTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGC
+
@CCFFDFDDHFFCEGHJJIJJGIHCHHCGIGJJGGIFHIIGBFCGIGGIJIIIJIJICGGJEHDGHHJICAHDDGIHHHHHGHB@DFFDD@@BACC><==
@19P
GTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTT
+
@?=DDDDDFDFAA<<E?GD<FBH?H@G@<???CC??BDFBF@GBBDDB89D99?).>=8=FAA@@=@G@E77CHCH><9B;CC;(;,5-;;;@:
@19Q
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCC
+
BB@FFFFFGGHGHHGHJIGGIGIGIGHGIIJJJEEHIJFGFHGIJJJIIIJJJIHJIJJHHHFFFFFFEEDD;?B@CDDDDCBDDDDDDDDDCCDDDDDDD
@19R
CTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BC@DFEFFHGHDHGIIJJJJCGEGDGHGIJJ<FHHGH@DFFICGIJJIJIIJGGHFHHHFFFFFCEDCECDDDDCCCDAAACDDEDDCCDCCCBDBDDDCD
@19S
TTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAAC
+
CCCFFFFFHHHGHJJIJIJJJJJJIHIJJJJJIGIJFIJJIGHIJJJJJIIFIIIIJJIJIIJJJJJJHHHEFHFFFFFEEDECEDDDEDCDDDDDD@CCD
@19T
TGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCG
+
@@@DF?DDHABFHIEHGIGIGEFHGGGEGGGGGAGDDFC?HGHFFFGGIIGIGCD=/;F?CHG>HHCC>A=7??CD;>;@@3?(5;5>CDACDDCAC:;@A
@19U
CTGCAAATTCTCCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
CC@FFFDEHHHHHIJIIJIIIJJGIGIIJFGIJJGHFGHIJIJJJHIGICA@FGHHIGGIEIIGFHFFFFFFFFEEEECDDDDDDDBBBDDDDDCDDDC
@19V
CCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAAT
+
@@<DDD?BFFFHHGIIID<IEEFCHAHHEGGE<<CGHCBEFDEBBGIHGABEADDGIIBABF?FDBC=F@D=@DA>
@19W
CCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGTAC
+
CCCFFFFFHHHHGJJJHIIJJJJJJJJJJJJJIIJEFJJJJIIIIIIICGIAHEEEFFF@@ACCEEFDCDDDBDDDDBCDDDBBDDDDDDDDDDCDCD4@C
@19X
AAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGC
+
@BCFDDFEFHFHHGGHHGGHIJIGJGHIJJJIJIJJJJJIJJGFEHJJJJJJJJIIIGJJIIJJJGHIJEHHHHFFFEDBCDDDDDDDDDDDDDCCBCDDC
@19Y
GAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCC
+
@@CFDFFFHHGHGCGGIEGII<CGHGGIJJIJDHIJJFHIJJJJJIIIIIJJJJ@GIJJJHHHHF@CDBDEEDDDDDDDDDDDDADCCDDCDDDDDEDDDE
@19Z
GTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGC
+
B@@DFFDFHGFHHIJGIIJJIJJJJJJJJJIIJJJJJIJJIJJIEIIGJIIJJJJJJIJIJJJIGEFGGIJJJJJIIJJJJFHGHHGHFFFFEEEEEEDED
@1A0
GGGCCGCTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACC
+
BCCFFFFFGHHHHJJJJJJJJJJJJIJJJJJJJJJIJJJJJJJJIJJJJ=AADFFFDDEDDDDDDDDDDDDDDDEDDDDDDDDEDDDDDDDDDDDDDDDD
@1A1
TGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTT
+
?@<DDDDDHBDDFG<AFEBA<F@ICCGEHICFG<CF<B?EFHCIIIGHCGHAG@@?FHB@F@GHG>DHHFD.=DHAHHF:?EB(9?=CCA@CDEECCCDCD
@1A2
GCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAAAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTA
+
??@FFDFFDHFHGIIIHIGGECIGIJJIHCCGCHGIIIJIIGIJJJICHIIIIGGFHGHIJHIIIIJIJJJJFHEGIGCGCGHCEHDEDBDFFECAACC
@1A3
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
CC@FFEFEFHFHG@EHHEHICDGIIGAGHGHHGIIGGIIIHHIBGGDHIIIGIIIG@EHGIEGHG);BGGC>EHFHFFFFDCCECE;A?A=ABCCBCB9<5
@1A4
AGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTT
+
@@CFFFFFGHHHHIJIIJJJJJJJJJJIJGIJJJJJIJJJJFHIJGGIJIIJJEIIJJHHHGFFDDEEEDFDDDBDDDDDDDDDCDDDDEDDDDCDDDDDD
@1A5
GTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACT
+
@@@AADDDDHF<DEA?CCEC@CEGIEHC@<??FEEBGIIHIEH@??FHGHGEBFHCDA@FFB=FGIHG=@.===A3=>B>>)77>CCAADDCCCADDD;55
@1A6
TTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGC
+
@@<DDDDDHFFHHGCGGHEEEFABFGHHGGGIIJGIGHGGDD8FEGGBFBHBFHIIAFFGIIIGEHGHFF@DEEAE>CCCCDDDBDDDC@C<?B<<A<ACC
@1A7
GGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGG
+
CC@FFFFFHGHGGJJIIAHIIJIHHHIEIJJJDIJGIGHGIJIIIGGII;FHHIIHIGGGIIJJFHH@EGIJJJGHHHGHFFFF?CEEEEEECDEDDD
@1A8
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGG
+
@<@DFDEFFHDBHBFGG=EEHGHGGHGIEBGG<GGBEEHHIHGGIIFHH@?FC<FHGIIEEHIGI>DHAEEB;?=AC.9;;?<'8@>@AACCCCC>AC48<
@1A9
GATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGAAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTGGCTCCCAGGTACCTGGGGATA
+
?;;DDBD>ABD??@E:)?E<9<C+223CAE<<??CCD9B@**6?(96-(8=1).1;@))7=3)77;(6>,(((5=259'35<>>>?A<(4>>A:>>9(5<
@1AA
CTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAG
+
CCCFFFFFHGHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJBGHHIIIJJJJJJJJJJJJJHHFDDDDDDDDDDDBDCDDDDDDDDDDDDDDDDDDDDD
@1AB
CGCGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCC
+
@@@ADDFFABDADFHIGFHHIHCFDGCHGIGDGAEGC??DCIIGG@HIIEBGHFEHC?BBGGGHDGHG@E9CGHHHH@?DDB?AC@BDDDDDACDDDCC
@1AC
ATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGG
+
CC@FFFFEHHHHHJJJJJJJJHIHJIIGHIJJIJJJJIJIJJJFGIIJIJJJJJGIJIIJJHFFFFFEDDDDBBDDDDDDDDDDDDDDDDDEEDEDDDDD
@1AD
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CB@FFFFFHHHHHJJJJJCHIJGHIJJJJIJJJJJJJJJJJIJJJIIJJIJJJHHHGHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDDDDDBBDDDDDD
@1AE
TGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTT
+
@C@DFEFFHHHHHIJJJJJJJIJIJIJJJJJIJJIJJJJJJJJIIIIDGGHIGIIGIGHHIIIIGEHEHHHGEEHDFFFDCDCDDDDDEDDDCDDDDBDDD
@1AF
CGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGG
+
@@@DDDDDHHFHHIGHIJJEHIIJJJJIG5@EHHHGHHHFFDDDDDDDDDDCDDCCDCDDDDDB>B@BDDDDDDDDDDDDDBBBBDDDDDDDDBDDDDDDD
@1AG
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
CCCFFFFEHHHHHJJJJJJJJJJIIJJJJJJJJJJJJJJJJJIJJJJJJJJIJJIJBEFBFFDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDC
@1AH
CATAGCTACTCTGCTGTCCATAGCTGCTCGGCTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTG
+
<;?DD8DBA=DA4:A2C>FCEDF9,3AE4C<):?)?B?*9D*0?DBBDDCEC@;4B=B@CCA;AAEA:;>C).7=7;;7?8>@79?A;;>;5<553>AA>A
@1AI
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJJJJJDHIIJJJJJJJJJJJJHHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEEEDDDDDD
@1AJ
TTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
CCCFFFFFHHHHHJJJJCGIJJHIIIHGIJJIJJGGIIIICGIJJJJIJJIIIJIIIJIJJHEEEFHFFFEACCECDCDDDECECDDDDCDDCDCCDACD
@1AK
CTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTG
+
=?=A=AADFFDBFIEBB<?F;8F@?E11?9C@:@D?9?)=)B@;;5=5=3=EE37ADD7.?;6>,3>B@5@ABBB>>::5?B828+8+>BB>(+2(2>AB
@1AL
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
@@@DFFFBDHDFBFBHGEHGIHCHICHHI@??CGEHGDHGBFHHHI7BD;CCF8@CHDHH?BE?CA@AACD?CACCCCCCCAA?CA@>@CCCCECCCD@>@
@1AM
CCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCCAGTT
+
?;<ADDDDHADFHDCF9CDFGI@+A@3AC>HGEFDHGE@E;BDE>GF3DF@D@?<?BFB?FCGIIGIIHBF>A@H@=C=ECEEC?DDD>@DCCCCCCDC;C
@1AN
CTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCAT
+
?@<ABD8ADFF:AFFHIII3EBADFGGBHD@::EEH<?DGAA?:<BDHDFGEHFH@B:8/6(.8=@DFFH4@EE@A?CE:?CHC;;@;CCA@CCC;A3>(
@1AO
AATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTG
+
B@CFFFFFHHGHHJJIIGJJJJJHGEGIIEGHJJIJEGIJDGICHGHIGD>BDHIGEHEGFHHHDCHGGHEHFHHFE<@BB;AACACDCDDBA<><BB@@C
@1AP
GCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
CCCFFFFDHGHHHFFHIIJJJIJJJHIJHHIGHIJJJJJJJJJJJJJJJJJJJJJJJIJJIIJHHHFFFFEDEEEEDDDDDDDDDDDDDDDD@C>CCDDE
@1AQ
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
@@CFFFFFHHHHHJJJJJJJJJIJJJJJJJJIJJIJJJJJJJJJJJGHIJIJDHIIHHGHHHFFFFD>CEEEDDDCCDCDDDDDDBDCDDDDDEDDDCDDD
@1AR
CGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGT
+
BCCFDFFFHHHHHIIIJJJJIJJJJJJJJJJIJJJJJJJIJJJJJJJJIIJJJJJJJJJJIJJJJJJJJHHHHHFFDDEDDDDDDD@CDBDEDDDDDDDDA
@1AS
CGCCCGTTCACCCATTAGCTTCCTGTTACACAGAATAAATGTTTAGATTACTCCCACCCACCCTCAAATAAAGTGCACAGTCCATGGCAGACCATAGAAT
+
CCCFFFFFHHHGHJJIIJIJJJJJJJJJIJJJJJJJJJJJJBFEIIIJIJJIJJIJJIIJJIEDGIJHHHHHHADFFFFECEEEEEDDDDBDDDDDDDDC
@1AT
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATAT
+
@@@FFFFFDHHBHGHIIIIIJGEHHHJIHJGGGAAFGHGGGGFGIJ8BFHGIIJIJJIGGIGIAHHHGFDFFCCECCBDDDECCCDDD;AB??@CCCCCDC
@1AU
TCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJIHIIJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJIJJJJJIJIJJJIHHHHHFDEFEEEEEFEEDDD
@1AV
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJCHIHIJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFFEEEEEEDDDDDDDEEFEDDDDDDDDDDDDDDDDDDDD
@1AW
TGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTG
+
CCCFFFFFHHHHHJJIJJJJJJJJJIIJJJJJIJJJJIJJJJIJGIIJJJJJJGIIJJJIJJJJJGIJJJJJJJJJIJJJJJIIIJHHHHHHFFFFFFDE
@1AX
ATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATC
+
@CCFFFFFHFHHHJIJJIJJIJJJJJJIJJJJJIGHIJAHIJJJJHGGIIJJH?EFFFFFFFEDEEDDDDDDDDDDDE>CDCDCDEDDDD5<BDDDDDDED
@1AY
CCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAAT
+
CCCFFFFFHHHHHJIJJIJJIIJIJIJJIJIJJJJJJJJJJJJJJJJJIIIIJJJGIJIJJIJIIJJIJJJJJJJJJHGHHHHFFFFEFEDEEEEDEDDDD
@1AZ
CTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTG
+
CCCFFDFFHHHHHIJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJHHHHFFFFFFEEDDDDDDDDDDDDDACDDDDDDDDDDDDDDDDDDDDDD
@1B0
CTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATC
+
CCCFFFFFHHHHHJJJJJJIIJJJJJJJHIIIIJJJJJJFHIJJJJJJJIIJJJJJJJIJJJJJJJJJJJJJIIJJHGHHFHFFFFFEEEEEEDDDDEEE
@1B1
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
CCCFFFFFHHHGHJJJJIJJJJJJJJJJJJJJIJJJIIJJJJJJJJJJFIJIIIIIJJIJJJJJJIHHEHHFFFFFEEEEEEDDD=BBDBCDDEDDCDDD
@1B2
GTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGG
+
CCCFFFFFHGHHGJJJJJJJJJJJJJJIJIIJJJJJHJJJJJIJIJJJJJJJJGIIGGIIJGIJIJHEHHGHFFFFDDFEDDEEEEEDCCEEDDDB
@1B3
CCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCT
+
CCCFFFFFHHHHHJJJJJJJHIIHJJJJJJJJJIHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIHEEHHHFFFFFFD@CCDDDDC
@1B4
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGAGGG
+
8=?DDDDDBDDD?,A:<EEAC:FC>EHDHDHB??3?F4::CB?:?DDDBGE2D8;;FCFB7C;D@4@;;CEA?BCBBBB3:44+3(9((44:@:442(820
@1B5
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
@<@DFDDDFFHHDEGFHGGG9EDEEHICEGGIIFGHHIHJGJIGIGFBGGEHIJJI;=D?@CCCECABB?BDACACDCDCACABDDDBDDCDDDDDCDCDC
@1B6
CCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTC
+
@;?DDDDDD?HHD:CFHG>AA?FFHGGI3+AED<4CC<CFHHECF390:3BD0?GA9BG4BDBC>CFCGBBBF:@7@D7==C@DC>CEEHFEEBB@>;ACC
@1B7
TTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTT
+
?@@DD?DDA:=BDGCGEEIIGEEHI9CF@BD?H<<?C?EGIG<D3??BBFHD<FGFHFEAFHIG=CFD@FCDHEEHGHCAA??C@?CDED;6>>>>@>CDC
@1B8
CCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGC
+
=;?A:=BABFFF?E1<AF1A9ABBD>?F9<91:F6?D9D6:;;F@'558A;@;2?33.;;(5;5=A@@@@@@?<9:((++:A@::150)0&+::9&+2&9:
@1B9
CATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGT
+
@@CFDDDFHAHHH<CB@FGHIIIJIEHHCCEHIJJJJJDGDHIGAHHIG<F5@HGAEEFHFFFCDDDDDC@BDDBBDDDDDEDDD>CDDBBD?3@AB@BB0
@1BA
CATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJGGHIJJJJJJJJJJJJGHIJIJJHHHFFFFFEDDDDDDEEDFDDDDDDDDDDDDDDDDEDEDD
@1BB
CTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGTCTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACC
+
?;;DD4=:=AC4C44+AD?A333A:AFDEI9E@?9C91::1:BDD9?DD9D?9BDE:(-<')=@CA=7@)@@C?=).77);)....(3.(66;>>>>555
@1BC
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CC@DFFBBDFDHAGBABFFEG8CEDECGHBGHGHHGHGI9DFIGADDHCFEHHGCGHIIIGIICHCEGHFHHFDC;>>CCCD?A>C@CAD9@C?CCB5@
@1BD
ATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTC
+
;?;:?BDAF?FDFEAE@<C,<<?IFC9CAEC>EGCG?E9EECFGEDA9?GH?DHB>F?B9BB<FGHGGE>=FHICFFFGHEFHHGE4CCACAEDCEDDE@C
@1BE
GTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTC
+
CCCFFFFFGFHGDHIHIIIEIGJJJJJJGFHEHEHGJGIGAGFHJJJGFHBFHGIIJJIJGGHHGIGHJIHGIJJIIIHGIGGCGDEEFFHFFFFFDEDE
@1BF
GTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGC
+
BB@FFFDFHHGHHJJJHFDDDDDDDBDDDDD6<BCEEDEDDDDDDDDDDDBDDBDDDDDDEEDACCEDDDDDDDDDDDCDDDDDDDDDDDDDCCCDDDDD
@1BG
CCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACAT
+
@;@DBBA:=2=2CGIIIIIIBEC?<C:A<A?C@<HG=??FED?GB)::?8998/B??6-65C@8C@@@E>E>EFCAD;;?;;'55(;>=9B:::@B?:5@B
@1BH
CCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTC
+
CCCFFFFFHGHHHIGIJIJIJJJJJIJJJJJJGIIHHHIJIJJJJIJJIIEHHHHFFHHFFDDDDDDDDD@BDDDDDDDDDDDDDD@BDCDDDDDDDDD>C
@1BI
TCTCGCAAAACGTTTTTACCTTGTGTTGTGAGCTGCCCTTCTTGAGCTTGTACACAACGAAGCTCTTCAATGGTTTCCTTCAGAGAATCCCTTTCTGTTCT
+
CBBFFFDFHHHHFHIIJJJIJJJGJJJJHIGIIJJJJGIJJJJIJJJJJGIGEGEIJIFIIHHFFFFFFFEEECEEDDCDDDDCDDDDDDDDCDCDDDDDE
@1BJ
CTTGACCACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTT
+
CCCFFFFFHHHHHHGJJJJIJIJGIIJJIIIIJHGFFIJJGJJIIGIIIIJIGHIJJIJIJIIHFFEEEEEDCBDDDDCCCDDDDDDDDDCDDDDCDDD>C
@1BK
CTAGAGGATCAAGTTTCAAAGGGGTTGCAGGAGACAGGCCCTGAGACCCATTCATCAGCTGTGTGTTCTGAATCTGCATCTCCTCAGCCTCAAACTCCATG
+
C@@FDFFDHHDBFEHFDDHHACHG@FAGGF;@DEGFHFDGGGGGEEGHCCEGIIIGEEGEHDH7?AHEFDDFFFEDCAAAAACCCCCCCCC@CCCC@CCCC
@1BL
GTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTC
+
@@@FFFFFHHGHHIIIJIIGIJJJJJJHIGGIGFFHEHIJJIDGHFHGJJJIJJJJJIJJIJJJIIJHHHEFFFFDDECEDCDDDBDCDDBBDDDDDDD?C
@1BM
ACCTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTC
+
@@@FFFFDBHHHFGGGHHIJGGGIGGHIIGIJJ=DGHGIIGJIIHIGGGIIJJIIGIIIGHHJJIFEHGHHFFFEFFFEEEDDEEEDECDECDFEDDD@DC
@1BN
CTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGGACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCG
+
=@@DDDDDBFHHAEGCFHDHD??FFEGBD?BFEIIIIEHICEAHEHBCBCDDCCC;ACDC(;=?BACDD@;;8?@?CBB>BBCEEDC>>ACCCCC:@ACCB
@1BO
GGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTT
+
@@@BDD8DF<A<?FG>F?A@G@ACFHFGGI<CDBCDDGA@FADEHG>)B8BBFFGCFBGGEGG>;CHI@DHGEEF7?CEEHCEC9>;=>A:<?:@@>C4:>
@1BP
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
@CCFFFFDHGHHAGHEFHIHIJJIJGHGIJJJ8@GHHIJEIII=CFCHIIHGHHGHHFFDF>CCCECDDDDDCDACDDDDDDDEACCDDDDDCCC>CCCCC
@1BQ
TGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTC
+
@CCFDFFFHHHHFEHIJIIGJIIIIJJIHIGEIIIJIFHIJGGIIJJJJIJJIGIGGGGEEFHDDA>ADDDDDDDDBBDDDCDDEEEDDDDECCDCCCDDD
@1BR
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
@@@FFFFFDHHGFGIIBGIJDGIGFBHGIBGGIBDGGCGIJJIF/=CHDHHFGGGHIIJHHHHHFF83?CECDDCDD;ACDDDDDDDDCDDDD@CDCDEDC
@1BS
CTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTT
+
@@?DFFDFHGGHDHDFHIIHHIHHGGHGE@HIGGICFHECHFEGHJJIIGIIDHAHIIECJFFFGGHHGIGIIIGHGEGGDEEGIGHHEHEHEDEFDFEEE
@1BT
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTT
+
@@@FDFFFHHHGHIIHHGGIJJJIJJJHIJDDGIGGIJGFHIJIEHIIJJIJIJJJIIJG?ECHHFDFFFFCEEEACCDDDBDDDDDDDDCDDDEEDDCCD
@1BU
AGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGT
+
@BCDDFFFHHHHHJJJJJJIJJJJJJJJGIJJJJJJJJJJJJIJJCHIJJJJJGHHHHFFFFFFEEEEDDDDDD<BDDDDDDCEEDEDDDDDDDDDDDDD8
@1BV
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
@@CFFFFFHHDHHJIIIGEGHGIIJJJJJEGHGIIJ@FHIIEGGDFHIIJJIJJJIEIHHEHFHFFEEEEDDEDCCDD8=B0ACCDDDBBBDDDACCCDDD
@1BW
TGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACC
+
@@@FDDFAFB@DFGGIGGGIIIF>B??DDCDHEIIGIIIIIIHIGAGGGIGGIIIGIIIGCACECE?CEFCD3@;@@BBBCBB@BCCCC@C:?C>BDDDCC
@1BX
ACCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCT
+
@CCFFFFFHHHHHJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHHFFFFEEEEEDEDDDDDADFEDDDDDDDEEFEDD
@1BY
CTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIIJJJIJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHHHHHHFFFFFFFEEEEEEDDDCDEDD
@1BZ
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
CCCFFFFFHHHHHJ@GHJJJDHIJJJJJJJJJJJJHHHHFFDDEDEEDDDDDDDDDDDDECDDDDCDDDDDDDDDDDDDDDCDCDCDDDCDDBDDDDDDC
@1C0
GCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAAC
+
CC@FFFFFH<DBHIGGGGGGHFIGFHEIGGIGBE?FE9C?BCA@CFCIHEDHHEGHFGB?FBGGGCHAEHIJEFHIICHHEAEHHD=BD;>>;ACA
@1C1
TGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@B@DDFFFHHGHHIJHIJFHIHHIJJJJJIIJJJJIIJIJJJJJJJIJJJJJJJJIIJJJJJHIIJJJHHHHFDDDDDDDDDCDCCDCDDEEDDDDDDDD
@1C2
CTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTT
+
CCCFFDDDHGHHGIHB@FA@FHECABAFFGHIIIGHGIGGGGEHIGGIGGGHFHIEFGIEIIGIGHGFEEFIII@CGHIHHHHHHFFFBBCACEAAAC@CC
@1C3
ATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTT
+
@@CFFFDDFHGFHGIHIGGIJGIJHGJGEIGCHEIIJIHHGHGGIGIJJJJIHIBDHIJDIJIGIJIHGHJIEEBFHIIGHIJCHJGHHHHHCHHFFFDCD
@1C4
ACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAG
+
=??;;?@@FFBADGHCBHHHGD2AE<GDC1??BGD@GHI;9D???DB89=F>@GGGGEH@;GEIGI;7AC>C;B;B>>?;;;;>CD:5<BBB>55509C
@1C5
AGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@@FFFFDHHHFAHGGIJHHGIIIIIIIIIGIDGGIJJFIJIIIGIJFJJJJJJHHIIGIJDHAEHFEFEFFFFEEEE;>AB>ADD<CBDDDDDCDD8AC
@1C6
GTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTG
+
C@CFFFFFHHGHHJJJJJJJHIJJJJJHHJIIHIHIGJJJJJJIJJJIJJJJJJIJJJJJIIJJJJJIJJEEGEIIIIIJIIJJGEHFHFFFFFDDDDBCD
@1C7
AGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATC
+
@C@DFFFDFF?FHIJJCGIGGIJGHIFIIJIIJJJJJHIIJJIIIJJEG=EFFFFFFEECCFEDDCDDDCDCDB@>BDDDDDDDDDACEDD@ACCDDCDAD
@1C8
GGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGAAT
+
@@@=DD=BDD:@C:<?@FEDGHIIGG??;:??:BDEGGIIGGHGEH(*8BBB@GHHGG5@=>E;CE=?DBC@;>CCC>AAA?@B:-9><C>>:><49>(:+
@1C9
CATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACC
+
@@?DD<D?:=DD?@FBEFE<FG9C2<EC@:CF6:FBAF8<<C;C8=C87@DEECEFEFEA;@B@;;@>A@@B@@A@;-5::;:>AAAA:;>@899<9BB8<
@1CA
GTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAAT
+
@@@DDDDDBDBDFEGGGEHFCHHECF<EBBBHGIHEGHG@?G?D?FFGGH?FEGICH@FGBDFHEII@;BFEEHDHGIADC>EHEEA????7?.6;@>>;A
@1CB
CGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTG
+
@CCFDDFFDDHDHIJJI@GHGGEHI4C?GHIG@FAFB<=BFDFEEIBHBDHIIJJFGEEF@AC=DEG7@EA>A==;?BEA9>BB8AC>;:A:>AB889@88
@1CC
GCTAAGCATTTGTTAAAATGAGTGAAAAACTCGCTTCAGCAATGCAATGATATGTGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATG
+
CCCFFFDFHHHHFIIJJJJJJIJIGHIIJJJIJFIIJGJIJJJJIIJJJJJJJJJIGJIGHJJJIJCEEEEHHEHFEFFFFFEDECEEEDDDDDEDEDED
@1CD
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGGGGTGACTGTAGCAGTGGTGG
+
@@@DDDDB?CFDBIIII@BCAAAAFGDFCFGDBFECGGGD=9?FEHIIDBHHIIDGC;AAEHGEDHEEA?BBBCBBCCCB'3;99BCCCCAAC@CCCC@?8
@1CE
CTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTG
+
@C@DFFAEBFFFHGGGHGIEIGHFHBGHIJGIEEGDGCHIIIIIIHGI?FHIGGG@FBFHIGFHIIJIIDFFHFFFEECEEE;?CCDDCCBDDDC@>>CDC
@1CF
ATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCT
+
@CCFFFFDFHHHHIIIIJIGIJGIIGIIFFFGGGIJIIIJJJGIJIIJIJHGII@DACFGIGC@ECCCEHEFC@CFEDECCEEEEEECCC?@ABBDD?C
@1CG
CAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTT
+
CCCFFFDDHHHHHJJBGIHIGIICIIJJJJJJJEGHGIJGIIJJJJJIIIDFHGIEGD?FHJJHGIIDBFHJGHIAGHJGHHJIAHEHHHAECCDEFFFD
@1CH
CTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJIJJIJIHIJJIJIJIJIIJJJJIJJJJIIJJIJIIGHHH
@1CI
CGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGAC
+
CCCFFFFFFHHHHJJJJGJJIJJJHJJJJJJJJJFHIJJJJJJJJJIJJIJIJJJIHHIJJJJJJJJHHHHFFFFEEEEEEDDDDDDDDDDDDDDDDDDD
@1CJ
GTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATA
+
B@BFFFFFHHHHHJJHIIIJJIHIIJIIJJJJJJJJJJJIGIJJJJJIFGHHIJGIJIGJ;@BDDDDDDDCCDDDDDEDDCB4>CBBBDDDDBDCCDD
@1CK
CCCCATCCCAAGCCTAAGTAAAAAGTAATCCCCAAATCCCTCTGCCCATTCACCCATTAGCTTCCTGTTACACAGAATAAATGTTTAGATTACTCCCACCC
+
CCCFFFFFHHHHHJJJJJIJJJJJJIIJJJJJJJJJJJJJJJIIJJJJJIJJJJJJJJJJJJJJJJJJJJIHHHHHFFFFFFFEEEEEEEEDDDDDDDDDD
@1CL
GTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGAG
+
CBCFFFFFHHHHHJJJGGIJJJIJJJIGIGJIIJJJJIJIIIJJJJJJJIJJJDE?EEBDCDDDDCDDDDDDDDDDDDDDDDDCDDDDCDDDDDDDDDD
@1CM
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
@@<?D;ABDF>:A3AFEBAH@?EAAF?FGDFHAHEC9??@F?8BFHBDCAEGEEHHEE@E>BDEB@;A9>1;AAACCAC>:AA>:<3>(:>:@C:@AC3A
@1CN
CGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAAT
+
C@CFFFFFHHHHHJJEGIIJJJJJIJJJJIJIJIJJJIJIJJJICGGIGHGJIJJHIGIJJHHHHFFDDDBDAABBBDEEEDDCEDDDEDDD?BDBCDDDD
@1CO
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGT
+
@?<?BDDDFBDF?CBDGIGICEGI?FGBFCE>DFEDHEGEGG??@=CAFHCGGGDCG@DAEEHEHEEEEECC>CCCBCBBCCCCCCCACCCEECCCCCCCC
@1CP
TCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTT
+
CCCFFFFFDFFHHJJJJIJGIIGGHGGIEHJJJJJC?ECFGGHGIIJIJDCHBDEH>@>>DDHHGIGIIGCGIGEGGE=@AE:AECCDBC;BCCAC;>CCC
@1CQ
CTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGT
+
;@@D;BBBFDFAHDEEBE@FBDDHAECBFHDFHEFDHCDFBF?F<<?F;DDH3?DFHE<9F=)=CFE47@=F)@G>;7==7?=C;7;BEB@;@CCCCCC;(
@1CR
TAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIIJJJJIJJJJJJJAGHIJJIHHHHHHFFFFDD>BBD=CDDEDD@CDDDDDDD
@1CS
GCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJGJJJJJJIJJJJIJJIJJJJJJJJJJJGHHHHIHHHHHFFF@CEEEEEECEDDEDEDDDDDDDCD
@1CT
CTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJEGHIJJJIIJIIJIJHHHHHHFFFFFEEEEEED
@1CU
GTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTG
+
@?@FFFFAHHHGHJIEHG@CHHDHHGIGGEGEHIGGIIIJJIJEFHIIDCCDFGGHJIJGGIHIIIJECEEHHDDFDCCC?@ACDDDDD@?@CDDC@@CDD
@1CV
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
CCCFFDFFHHHHHJIJJJJJJJJIJJJJJJJJJJJHIIJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIIIHGHFHHFFFFFFFEDEEEDDDDDDDDDD@BB
@1CW
GTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAAT
+
@@@DDADDF?CBDC<<CFECIBB?4:FFCHHI9CHHH?:????@;G@???DF<FF?FDFIEI@F<FCFI;8==CEA;@@CCAEAEF?@BBB>?AAB:59?@
@1CX
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJJJJIHHHIIIJJJJJJJJJJJJJIJIJJJJJJJJHHHFFDFFFEEEEEEDDDDDDDEEEEDDDDDDCDDDDDDDDDADDD
@1CY
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTGCTGCCTGTAGCTGCCGCTCTGTTGGCTATATTGACTTG
+
CCCFFFFFFHHHHJJJJJBGFHIJJJJJJIJJJIJJJJIJJJJJJJJJJJJJJJJJJJJHIJIJJJJJIJJJJJJJH6ADFDDCEEDDDDDDEEFEDDDDD
@1CZ
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJIJJJJJIJJJJJJJIJJJJJJGJJJJJJIIJHHHHHFFF<?D>CDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@1D0
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATAT
+
@@CDFFFDHHHGHIJHEHJGIJJAEHIGHGIIIJBGIJJJIJJJJFGGIJJIJJJIHHJHHHHHFFFFFEEEDEDDDDDDDDDCFDEEDDDDDDACDDEDD
@1D1
CAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTC
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJJJJIJJJJJJHHHHHFFFFFDDEEDDDCDDDDD=BDBDDDDDDDDBDDDDDDDD
@1D2
CTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTG
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJGHIJJJJJJJJJJJJJJIGIJJJJJFHIIJJJIHIJJIJHHHGHFFFFFFEEEEECEDDDDDDDCDDDDDEDED
@1D3
CCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCT
+
@@@?DBD;FFHBDDG)CFH>G9EHEGG9E@CGH*??BFHD)07@F;BB>)8.@==@6===C)=2;B7;),39?;79(>583&59>9)5<C(((+<B5&&55
@1D4
CCTGCCCATAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATAAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
?;?=B3ABD>D4<EAA?13CF++C22CE:)&&)68A(3>755-<8((3(+>A99>:<8<0&2234>:4A3>>A(4>8>((:34((+4:>A:>?9<AA<342
@1D5
CTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAAC
+
@@@DDEFFHHHDHGIDGHGHIBEHGEHGIBFGEEDGIIGGIJCEGC?CCGEBEBCCEEEDCDDDCDCCDDCDCCDDDBDCABCCCCCCDDCCDDDD@BDD
@1D6
CTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGG
+
@CCFDFFFHHGGHJJGCGIIIICHIJJJJIGGIIJEGBHFFCG@GGIJJJICFBFHEHHGADGGDA;AEEHFFFFFDCDCCDCCDDDDDDD@BD>ACC<<?
@1D7
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
@CCFFDDB?DFHFIHGFDFGHGCHIHIHGIGIGCFCDCDGII<DH?FFGFHDAFG>FHCCEDG78A8?>@DECCCCCCDDD>;>C>A@CA@3>AC;>:CCD
@1D8
CTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTG
+
CCCFFDDFHFHDHIIJIIJGIJGIJJGIIIHIFGHHIIJJJIIGIGIIJJJIIGGIHIJJFDFGCHCHGHHJJIIJCDHEACHFEFFFFDFFCEEEEDED@
@1D9
CTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGG
+
@@@FADDDDBFFFHCGIBHHEHHGC@EBEGGIIBCDGFHGEIDDDGIIEE@?FHIEIEDBFHIAAG@7@EAHC?7?CEECCCC'9?B8>>:@CCACBC?@B
@1DA
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
CCCDFFDFDHFDHEGDEIIBIIEHFGEHJJJJGGGDC?DFDFDH@GBGGDGIB@FFHHGHFACEEFFBECAABBD@C3?ACDDCACDDDCCDCC?CCCDD
@1DB
GTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCAT
+
@@@?BBDDFBD>FB?FEG>E:EA<3<F?EFE;EGCF4C919CF?BGDDFDBFF9FEF><D?9C;((=C@)7@EEDEF?AEAE?;??@DB>@<A@;?BBBA
@1DC
CCGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCAT
+
CCCFFFFFHHHHHIJJIJJJJIJJJJJJJJIJJJJJJJJJJJJJJJIIJJJJJJJJJJIHHHHHHFFFFFFEEEEEDDDDDDDDEDDDDDDDDDDDDDDEE
@1DD
TAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCC
+
@@@?BDBDFDH;CBHHEGGGIFICHGIIB=DGHGFGHIIBG@69?DE;@AH;@FHEE@E=CAEH@B@D@A@>BCBC@ACCCB:;==:@CC@CB@.09@CCB
@1DE
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHJJJJGJIJJJJJJJJCGHHIJJJJJJJJJJJJJJJJJJJIJJJHHHFFFEEEDEEDDDDDDDDDDDDEEEEDDDDDDDDDDDDDDDDA
@1DF
GGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGG
+
@@CFFFBBFFHHHGIIHEEHIJFGFHAFGBGHIIJHGGBHIGGCEHGHHHJJJJFHHHHHFFFFFFEE@CEABDBBDDCDDD9@DBCCDCDDCCA@DBDBD
@1DG
CCCCTGTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTG
+
@@@FDFDFHGFFFHGIIIHIIJJJJIJJIFIIJIIJIJIJIIIIIFIIIJJIJGEIIJJJJIJJJIGIJJGHCHGFFFFFDEEDCCEDDDDDDDDCDDB@B
@1DH
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTC
+
CCCDFFFFHHHHHJJJJIJJJJJJJJJJJJJJJIJJIJJJJGHIJJJJJIIJJJJJJCHIHHHHHFFFEEEEEDDDDDDEEDEDDDDDDDDDCDDDDDDDD
@1DI
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
B@BDFFFFHHGDDIGJJJJIHIIIJIJIGIJJJGHHHIGGII?DGHIBGIGGHCDHIGHGFFFFCCDEDDDCCDDCDDDD@CCDDDDDCDCDDEDDDDDDC
@1DJ
TGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGC
+
@@@DBDDBCB::?CA<EDFFIFEE?<F?FFG<FFE@?FFGI;DGD;BCFF?D.=BBCB>@FF88C@CFFICED=BAC>@@6>BDABABDBBBE:@:>3:>A
@1DK
GCACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCA
+
@CCFFFFFHHGFHIIHIHJIIHI?FCFGHJJGJJIGHDHHGIJIGIIIJJIIIIIHIGGJIIGJIGIGGH@EGGFHGCHHFFFFFFEDDEEEDDDADDDD
@1DL
CTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTC
+
BC@DDFFDHHHHHJJJJIJGHGHJIJJJJJGFHIIIJJIJJJJJIJGIIIIFGHGHIIIIJGEHJJGIIGGIGHIJJJHDF=CEHCBCDFFFCCDEEDED
@1DM
AGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGT
+
C<BFFFFFHHFFHJIJJIGEGEGHGGIIIIJJGJIGGEHHGGIJIIGIIGHIJJJJIBGGEECECE>CHCFFFFEDCEEDD;5>@>CBB@DD?CDDBCDD8
@1DN
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
@CCFFFFFHHHDHJJEEHIHEHGIIIJIJIJJJIIGIJIIIGICHHGIJJJIEHGGIIIGHHCHEDDFFDEEDEEDCECDDDDDDCCDDCCDDBCDDB99@
@1DO
CTGGGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACT
+
@;@DDDD??;ADDBFG9FEGHAFHIGEH:?GGHGEHG?BB:BDDHGD@DBFC>F@CC3==FEH5;?=C=C@CDCAA=;;>5?8=B@CCCCCBBB@B>??<>
@1DP
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
CCCFFFDFHHFHHIJIJJJJJJJJJJJJJJJJJJJJJJIJJJIJIJJJJIJJJIJGJHHIJIIJJJJGGHHHFFFFFEDEEEEDCDDDDDDDD<BB@BD@D
@1DQ
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGGGGCTGCTGCCCATAGCTGCTTT
+
@@@DDD?DBFB?B3<FBEHGGICBAAHBAHHICHCDC?G?D?F@GH9*?B<D8??DFCEGHAH-:EE9@;@;(;-;AB',)9008@C@??339:44>?CCC
@1DR
CTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGT
+
@BCFFFFFDFHDDIIIJIIJJJGGEHHIJGHIIGIGGHICHGIJIJJJIIICIIIDGIJJJJIEHJIJJJHGEGIIIJJIIJDIJIHEFHFHHFFFFFFE
@1DS
GAAGAGTTTGGTAAGACACGTAGAACACAAGTCACCTAACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGG
+
@<?BDDABCFB;FBHE@DGG<EFEEE;FEF8?C@FICGHGGCB09@9?FGG6=4BFDFHEGHHDECEDBFCECEECC@CCCA:?CBCCCC@BB<>CCAC<
@1DT
GTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCT
+
@@@DDBDDHFDHF<FHHBHEHIJIJGGIIJEFGIJJJGIJJJJEIGIJJGGGGDGIEIJJIIIHHIIGGIGIGIJJECHJGFEECHFHFFFFFFBEAEEED
@1DU
CTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJIIIJJJJJJIJIJJJJJJJJHIJGHHHHHHFFFFFEE
@1DV
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
@@@FFDB?B?CDFEDHGIIIGGGIIIGGIGGGHGIGGGGHIGBGDHGCGGEHGIDHGHHHIDIEHIHEHEF>BDFFEE>ACCCCBBB'8<@BCACDCCAAA
@1DW
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGG
+
@BCDDFFFFHHHHIJJJIJJJJJIIJJJJJJHIGIJJJJJJIJJIIJJJJJJJJIJJJIGEHHIJHGHHHHFFFFFFEEECEDDDDDDDBDCDDD9<BBDD
@1DX
GTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
@C@FDDDDFFHDHHIIGIJGEIGGEHIJJGG@DEIBGBDCDH@GHIGIIJIIJIGGGIIGH@CCH>EHEH>@D?CCCCECCACACEC@BD@BDBBCDCD
@1DY
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGAC
+
CCCFFFFFHHHHHJIIJJJHIIIJJIJJJJJJJJJJJJJJIJJJIJJHHIJIJJJHGGFFFFEEEEDEDBDBDDDDDDDDDDCCCDDDDDDDDDDDDDDDD
@1DZ
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGC
+
CCCFFFFDDDDBDDDDDCDDDEEEEDDDDCCCBDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDCDCDD@CDDDDCDCACCDDDDDDDDD9ACDDC
@1E0
GTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCT
+
=:?BDBDBB<DFF4<:<<C@A;C?A<CHG8C2?F?CGA:?9*:B*?BECHEH@FGF?EHII2@6A>3>CC:A?C?ACACCC99?4@>555><>?CCCC?>C
@1E1
ATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAAT
+
?@@DF?DDFHFD>GGG>EBBB?B69637BBB@BB39C@@BBB07?CCA?BB<ABB@87@BCDE>C>;<@CCDACCCCCCCCCCCC@B9BBCCCB<@ACEBD
@1E2
CGCTTAATCAGACCCATCTCCATATCCACTGTGAGTGAGACAGGCATAGTTCAGGCCTTCAGGCTTGCCAGAAGGGCAGTAAGCCACTTGTTTTTCTTGGC
+
CCCFFFFFGGHHFJJJIHIIJJJIJIIIGIIHIIIIIHIIJIJGIJJJGHIJIJJJIJJJEIIIJJIIIIJGFFHFFFFCEEEDEDDCDDDDDDDDDDDDC
@1E3
GCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCT
+
CCCFFFFFHHHHHIJJJJIJJJJJJJJJJJJIJJIJJJJIJJJJJIJJJIJIJJJJIIJJIJJJJJJJJJJJJJJJJJJIJJIJJHH?EHFFFFDFFEEDE
@1E4
GCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATC
+
@@@DBDDFHBHDHCEFHIIEBGIJG>EHECHGJIJIFIJGDHGHGGEGCG@B@?99BDJGIJIIGH>FGDFHHIIIC>AC>7?A@@@BDCDCC>ACCCB?;
@1E5
ATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGC
+
CC@FFDFDHFHGHIJJJJIIGGIFHHGGHGICHGIBDHGEGGIIEHGGGGHJJIIIIIJ@GGAHF<?@EDFEDEC>CACD>@D;CDDEEDDDDCDDBB>CC
@1E6
GTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCC
+
@@@DDFFFGHHFHJJJJJFFDHIJIJFGGIIIIIIGG?DFGIJJJIIJGIGGGHIHIIHEBCEHHFFDDD@CCECCDDDD8CCDDDCDDDDDDDDDCDDD
@1E7
CAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCAC
+
@@@FFFFDFHHHHJJJHGHIIIJJIJJJJJJJJJJIJIIIIJJIDGJHHGIIIIHGHGHHIJIGIJIGHHHG7?>BD>>>C@CCD@@DDCCCDDDCCCCB
@1E8
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJJJJJJIJIJJJJJJIHIHHHGHFFFFFFFDDD8?BD=CDDEDDCCDDBDDD
@1E9
GGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTA
+
@@@DBDDDHFFHDGEBGHHGDHDEHGGHIIIHIIIIGIIGHCHFHIICHGCFEHFCFEHEE@FCFEHGCGEEHFF>BCECCCCC>CCBCDCCCCCCCCCC
@1EA
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CC@FFDEFFHGHGIEHIG@FEHIHEHICECHGHGGIIGG?FHHIIGI7BCBBAFHIGG;D>EH?ADFEDDDEDDECDDDD=@@CACDDCC@:@CDDDB@B
@1EB
ACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCT
+
@@@DFFDFHHFFHIIIIHIGIIBHFHGIIIIIIIIIIIII:AGAFHG=AEHFDEFHGHEHFFFFFEEEECBCCCCDDDDCBDDDDDDBDDDCDDDDEDDCA
@1EC
GTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGC
+
@@@DD?D;FB?FF@C@HGIIEGGHG?DFEIEFHIFCHIEHHIIIIIBFHIIBHIEHIHIEHFFCEE9B@@CCDCCC>>ACCDCCCCCAC>ABCCCCCACEA
@1ED
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
CCCFFFFFHHHHHJJIJJJJJJJJJHIJJJJJJJJJIJJJJJ?FHIFHIJIJJCHIJJHHFFFFEEDEDDDDDDDCDDDDDDDDDDDDDDDDDEDDDDDDD
@1EE
CCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTC
+
CCCFFFFFHHHHHIJJJGIIJJJJJJJIHIJJIJJJIJJJJJIJJIIJJJJJJJJJJJJJJJJJJJJIJJIIIJIJJJJJJIJJHFHHHHHFFFFFEEEED
@1EF
GTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGC
+
@@@DFFFFHDHHHHIFHIIIIJIIGIJJJJJGFFGHIEIJIDDGIJGFHEG@HGGIGDHHIDEGHGHHH>EFEFFFFACCEC@>CCDEEEDDDDCBBDDDB
@1EG
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGC
+
@CCFFFFFHHHHFGHGIIJJIGEGHGIHHGIJIFFHHIIFHIBEHHDHIIIHGJ=CHGGHGHEHHFEBD?CEDCEDDDCDDCDD>CCDDDDDCDDDDCDDC
@1EH
ACCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGCGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGG
+
??@1:D;DF><FFII;A:3FGIC9922<2@??::?9??FGC??DGD90/9?==8=A(5-.7?'-92,022::::A:>33?088@83?9>:234@9?22>??
@1EI
ATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACG
+
?@@D?D3AF?FB?BD@CFD9:C93AE?C@ECDCGA@0:?B@?DGE@BDD@<B;FBCCBFAFFCDA@==DEEACEEDDD>DDDA;>>@@BC@BB?@8<AB><
@1EJ
CTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTC
+
@@@FDDFFGHHGGIGIIGIJGHIJJJIIJJJJIGGCGGGEHHGIHIHGGEGHGEHEGHIJIIGIIIJJJJEGDHCDHIEHHHFEEFDEDBBAEAAEDC@CD
@1EK
GTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTG
+
@@@DDDDD<CFFHEDHEH@GHGCEG4CFHIGIIF?GCGGH4CGHDGFG0??FH=F@EHC;@AFDHACHIIHFCEEE698,;9:ACCC<@CCBCCCCCBBCC
@1EL
ATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGA
+
CCCFFFFFHFHHHJJJIJJJJJJJJHHJJJHIGGJGJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJJJIIJFIHHHHHHHFFFFFFEDEEEEEDDC
@1EM
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGT
+
@C@DFFFDHHHDHGGGIGIGHDHGGCHGHIHIJJGGIGHHGGGIJGIEICGIIIF(<<5<CD@>@CDCCDEDDD3:CCDD?C<BDBDD9<<CDDDCACC>
@1EN
CTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJGHGHIJGIIJJJJJJJJJIIJJJJJJJIJJJJJJJJJJHHHHHHFFFBFEEEEEEDDDDDDEDD
@1EO
TGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@@DFFFFHHDHHIIIJJJCFHIFHIGIGIHHIIIIJJIJHJJJIJJJJJFIEEFHHHHFFFFFEEEEEEEDCDDCDDDCDDDEDDDCDDCDDDDDDBDD
@1EP
GCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTG
+
BC@FFFFFDFHHDHJIIHIJJJJJJJJJIJJIIJJJIJJJJJGIJJJJIIJJJJJJJIIIJJJHHHHHHFFFFDDDCDDDDDDDDDFDDDDDDDDDDDDDD
@1EQ
CCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGC
+
C@@FFFFFHHHDAGG@DDGEHIGEEFGCC=DDAG=BD'95>@CCD9958?>5;>ACCACDDDA<<;-059::>ADCACDEACD>CBD8<55+28>CC:@>
@1ER
CTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTG
+
CCCFFFFFHHHHGIJJJIJJJJHJJJIJJJJIIIJIJJJJDHIJJJJJJJIJJJJJIFHJGGJJIIJJJHHHHHHFFDDACEECDDDDDDDEDDDDDDDDD
@1ES
CTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGG
+
BBCFADDDHHHHFIJJIJJJIGIIJIJJIJJIJJJJJFIJJIGIGIIGGIJJJ;BH=DFFF@CDDDDDDDDDDDDDDDDDDDD>BDDDDDDDDCDDDDDDD
@1ET
CAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACGCTGCCACTGAC
+
@<@FFFDDHFHHHJJJJJIHIJJIJJFIJIHEGHJIGJIJIJIJIIIJDGIJJIIJIJIIIJGGAHHGFEFFDDDDDDDDDDDDDCDECBBBDDDDDDDCD
@1EU
CTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGTTTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAA
+
??<D=DBDD<?:<A;:2C333<A<:F<E<@A@D:6DDDED>>)7?7=.8=ACDEEDD><A?@>7;>;<(;A>ABB>5;;5,:>AAAA>>?>:>A43<AA
@1EV
TTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGC
+
?@;ADDEFHGHFABFHIADHH>FAGGGGGCGHEGH@FCHGIG>FGGHEDBC>@ABA>ACAC;=ACBCC@>@DCCCCCBB?C@9<98@C@CCCCCCCCC::>
@1EW
CCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTC
+
CCCFFFFFHHHHHIIJGJJJJJIHHJJJJIJJIJJJJJJJJJJJJJJJJJJJJGIIIIIHFFFDCEEEDDDDDDDDDDDDDDDDDBB@B@BDDDDDDDBDD
@1EX
GTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGGGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGT
+
?=?DDDD<AF?FHGBGB>>FGGHCHGGCH@@FGGEI@EDFGGHGDF<FHE*:;3B<)??@B:BBC8)878;3;@EC=;A=BB;BCAC3>AC;@>>;53:95
@1EY
TGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGG
+
CCCFFFFFHHHHHJJJJIIJJIIJJJJJJJJJJJJJJJJJJJJJJIJJJJIJJJJJJHHHHHHFFFFFEEECEEDDDDDDDDDACDEEDDDDDDDDDDEDD
@1EZ
CTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATC
+
@C@DDFFFADFHHJJIIGIHJIIHHHGHIGJICFEHHFEDHHIIJJJGIFDGGIGGDHEGGGGC@CFFHGIJHGEHGCEAEEBC?B?AC@;CEDC>C=CCD
@1F0
TCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATC
+
@CCFFFFFHHHHHJJJJJJIIJIIJIIJJJJJJJJJJJJIIHIIJJIJIJJJJJJJIJFHIJIJGGIJJIJJJJJJJJJJJIFIIFHHHHFDFFFDEEFFD
@1F1
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@C@FFFFFDHDABGIIJJHIIIJJI<?FGDGHIIIEFGHIIGJJJIHCEGIJFHGEFHFFFDDCEEECCDA>CCDDED@ACCDCDACCCEDCCCDCCDD>?
@1F2
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJGHJJJJJJJJJJJJJIIJJIJJJIIJJIJJIIJHHHFFFFFEEDEEEDD8?B@DDDDDDDDDDDDDDDDDDDDD
@1F3
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CC@FFFFFHHHHHJJJJJJJHJJJJJJJJIJJJJIJJJJJJJJJIJJJJJJJJHHEHHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@1F4
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTT
+
@@@DFDEFHHDFFCGIII<FFIIJJII?FEHE<FHGIIJIIGCB=FHGB@GCHDEHGCDA)=AH?>@@DDFCC>ACEDBBD?BDCCDCCCDDDDDEDACC@
@1F5
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGGGGTCTGAGCCTGGGTATAGCTGACATCAGTGGG
+
?;?D+AB:=?DDDIAE4ABDAEED8CBAEEIIDA<@@:CCDD@BEI*0@74@7=.=CCCD3?D@A;@(93;';5>:>AA???9>AD3>:>:>A:>(4+4><
@1F6
GTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCCTTTAGCACAGTG
+
C@@FFFDFHGDFFHIEHFHII@HEGIIICGHGHHEHDGHGCHGHIGHGG@B>FGGIIIII>GA@EHHFGFFDDFEECAEDBCCCDD=?BBDCCDDDDC<CD
@1F7
CATTGTTACACATGATCTTATTACTTAAGATTTTTCCTCACTCATTCTTTGAAGAAAACGGTTTTAAGATTTTGTAGCTGATCACCTATGGTCTCTCCAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJGJJIJJJJJJJJJJIIJJJIIJJJJJJJJIIJJJJJJJEHJJHGFHHGDFFFFEEEEEDEDDDD
@1F8
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
@CCFFFFFHHHHHFHIIJJJJHJJJJJJIJJJJJJJJJJJJJJHIIIJJJIJJJJJJJJJJJJIJJJJJJJJJ=ADDDFECECEEDDDEEDDDDCDDDDDD
@1F9
GTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCC
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJIIJJJJIGHIIIIJJJJJJIJJIIJJJJJJHHHHFFFFFFEEEEEDEDDDD
@1FA
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCT
+
CC@FFFADBFF;CEHFBHHIGHGCHCHGGHG?EFGEHI<FEGEDHBGIGCHIJIG>>BBFHGIEADGCHCHBGBEEHE@EDEBED?9?BDA?BB:?8<:@@
@1FB
CTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAA
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJJJJJJJIIJJJJJJIJJJJJJJJIJJJJIJJIIJJJJIJJJJJHGHHHFFFFFFFEEEEEEEDDD
@1FC
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGT
+
?@<DD?DDHAA<<CGAE=DCACHH<AFHIIGICHGHICGIECGGHDHIG@FIIIEGGGCHFBEHDEECA>?CAC>>C<B@C:@:A@ACCCCCCCCC:49>?
@1FD
TCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTCTGTTTTA
+
@CCFFFFFGDHFHIJJJJJIGGJJJJJJJJJIGHIHIIHIGIIJJJGHJJGGIIGGBFHIGHIIJIJGGHIJIGGGGGIGIIGIHHHFGEDCFFFFFEE
@1FE
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJHHHIIIIJJJJJJJHHHHHHHFFFFFFDEEEEEEDDDDDDDDDBDC
@1FF
GTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCC
+
@BBFFFFFGHHHHJIJGHIJIJJIJHGGHIIJJJJJGJJIJJJJBGIIHHIIJJJJIIJJJIJJIGGJJJJIHGIJJJGHFFHHGGFFFFFDEEEDDDEDD
@1FG
GTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTG
+
@@@DDDDDFD:ACFGIIIIACHHEGCCHIEHBEBDDFGGGDEHIGIIGGGACHIECFFGIIECCG)=EIIECHHEDD>CCC>;@CDDDCCDDACCECCCC
@1FH
CAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
CCCFFFFFGHGHHJIJJJJJJCDGHIJHHIJJJJJJJJJIJJIIJHHJJJJJJJJJJJJHGIHHHGHHFFFFDDCDDDDDDDDDDDDDDEDDDDDDDDDD
@1FI
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CC@FFBDFFHDHFGHGGGIIJGJIJ8??FEHHGDHGHIJJJIDHAHIIGI@DGHJ:EFFDDDEEEECCCCCDDCACCDDDDC>CCDD:<CBDDDDDD<CCC
@1FJ
CAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTC
+
CCCFFFFFHHHHGJJJJIJIHIJJJJJJIJJHIIJJJJJIIJJGJIIIIIGJIJJJJHHHGHEFFFFDDEEDDDDDDDDD;@BBCDDCDDDDBDDDDDDDD
@1FK
CAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGC
+
@?<DDDDDDDFF?AFGGFEEBCDHGCFGIFEGGHIIIIIIIIGGII@AFGHGGGAGDCHAHEFFEEEEBBCCBBBBCCCBC@CCCCDDCCCCCCCCCCCBB
@1FL
TTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJIJIIJJJJJJJJ5@DCEEEEDDDDBDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@1FM
CGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACA
+
@@@DDDDDHHDF<FHGGHIGIEHIJJGGHIEHGDHGIDEGIJ>FEIJIGGGGGHGIGIGHGHIJIIJIHAHH??CEEFFFFFFCEDD@CACCCDDDDDDD
@1FN
CGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGG
+
@@@BDDDAD?FBDGHEB<FAGGHIF?FHEEBHGGGGB?BBD@DFGCHGG8A/CGGIGBEE@D@BDE@C;@ACCC@/83(9@>;9>BB05<A>C>>C?@:AB
@1FO
CTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCT
+
CCCFFFFFHFFDHGEHGHJJJFIHIGEGIIJIHGH?FHIJJGIIIGIIJJIIIJHIHIJHGIIIJGGGIGIBGHEGHGGGHH?EEFFDEFFEEDEEDA>CD
@1FP
GTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCT
+
C@@FFFFFFHGHHCHGHIIIJIJIIIJGHJJGIIIJJJIIGIJIIGDGEAHGFFDEEEDDDDCDDDEED:@ACDEFEEECB<@D?D<BDBDDEEEDCDDDD
@1FQ
GCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTT
+
CCCFFFFFHDHGDHIIJJJJJIJJJJGJJJIIJJJJJIIIJJIIJIJFHGIIJJIGIIIJJ@HHIJJIGIJJJJJIHHHHFFFFFFEEEEDDDCDDDDCDE
@1FR
GGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCT
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJGHIJJJH=BCD?CDDEDDCDDDDDDDDDDDDDDDDDDDDDDDD
@1FS
CCCCTATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCG
+
CCCFFFFFGHGHHFCFGHIGIHGIIJIIGIJJJJJJIJJFIJJGJII=EHHEFFFFEEEFCEEDDDDCCCBDDDDDDCDDD@CDDDEED:@CCDEEEDDDD
@1FT
CCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTC
+
@<@DBDDDAFFB>FHGHGIAE@EGEGGEHE>GGAF6DBDFEHGF9>ACCCCCCAC:@BB<@?@DC@:ACBB>@BBB?CCCCCC>AC?@CB?B?B9<<BCCC
@1FU
CTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCA
+
@@CFFEDDHFFFBHHIJAIHHIIIBHGIIIFHICBGGGGIIJGGBCGIBBBBFBFDHBGGIIEJIIEGF@HCAC>GCHEC>=@G4=7?EHEHDBDDFFAA
@1FV
CGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTG
+
??+BDDDDDHHAHGGEGHGGHGIIJJIJJGJIGGIJIJIHGHIGIGGIIGGIIJ=BEDCCEECCCCCDBDBBDDA>ACDDD@CCACABCDDDDDDAACCCC
@1FW
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
@@@DD+=8:CF?D>C?EEBHH;FFE>FEAF@<80@DHIII;888BC=@)==@7;@@A.==.?);;;7>.;;3@ACC;@;:5:;3><5<=?:>@@CC:(4+4
@1FX
CTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACT
+
@@CFDDDDHHHHHIGIIICHGCFGEGCFGHIIJCFEGGGJHCDBFGIGGHGG?FCHGG@HIIEGEHE;CECCEFDDDCEFCCEDBBCDD@CDDDDEEDDDD
@1FY
CCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCT
+
@@CFF?DFHHHHHJJJJJIJJJJJJJIJJJJGIJJJJJJJJJJJJHHHHEEFFFFEDEEEEDDDDDDDDDDD?BD2?B9CCDDDDBDD:?B>BDDDDDDDD
@1FZ
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
?@@D?DDDHAH?D@EGH<ACFGABC?CFIHGHGCB:9BGA8BFHHA/BBF:F7=@CFHHGDGEABC>CC@@CCB@@?BCCC@:ACCCCCCBBB5<?B@:>C
@1G0
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTACTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJHHEHHFFFFFEEEEEEDDD;@DDDDDDEDDCDDD
@1G1
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGC
+
@@@FFFFDBDBDDDCCCCDDCDCDDCDCBACCDDBDDDDBDDCDCDDDC?@CCDCDCCDDDDBDDDDAADDDCDCDCDDD:AC>CCC@>@?CBDD3>CCDD
@1G2
CAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGG
+
CCCFFFFFGHGHHJJJJJJJJJJJJJJIJJIJJJIJJJIJIJIJJJJJJJJJJJJJIGIJJJIHIJJFHHGHHGFEFCDEDBDDDDCDDEDDDDDDDDCDD
@1G3
CAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTC
+
CCCFFFFFHHHHHJJJJIJJJJIJJIJJJJJIJJJIJJJJJIJJJJJJJJJJIJIJHHIJJJJJHJJJHHHHHFFFFFEEEEEDDDDDCDDCDDDDDDDFC
@1G4
CGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTC
+
@@@DA@D>B<DB<4AFDHEAA<<A+9AFA?31:1???<?FH4*:9@?GH<BCF=(('-(.7.==7=585?A;;A3>;>?@2;BC355::<B<959>::8?9
@1G5
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
@@?DDDFFF?FHHIJICGFHHJIIIIHCHIGDHHIDIJGIJIJ=@FHGHCHGHIGIGJIF@EHF@BDFFECCE@CDCDC>ADDBC@5>@CFCCDCCCCDC
@1G6
GATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGC
+
C@CFFFFFFHHHFIJIIJIJIIGIJIJIIJIJJIIJGEHIIJIIGIIGJJIJJIIIGGIJGHGHIJJCCHEEHHFFFFFFEEEEDDDDDBDDDDEEDDDDA
@1G7
GGCGTGTGCTGCTGGACATGACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAA
+
CCCFFFDDHHHHFJJJJJJIJJGIGIIJJJJJJJJJJJHFFFFDDDCBDDDDDDDDDDDDDDDDEEDDDDEDDDDDDDDCDDCCCDDDDDDDDDDDDDBD
@1G8
GTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCG
+
CCCFFFFFHHGHHJIJJIJJJJJIJJJIJJJJJIJJJGIJJIJJJJJJJJHJJJJJJJJJJJJJJJJJJHFHHHHFFFFFFFEEDEDDDDDDDDDDD?CDB
@1G9
GGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CC@FFFFFHHHFHIJIJEIJJJJIIJIJJJJJJJIJJJJJJJJIJJJJJJJJIJGIIJIGIIGHIIFHGHHHFFFFFEEEEEEDDDDDDDDDBDDDDDABD
@1GA
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
<@@FFFFFHFFHDGGJIJGIGGGGGHIA:?CFHIGIJJJJIEGGGGIJDGGIGJFHGHCECACE9BCECEEEEDDDD2=@5>ACDDC@BDDBCDDDCA@@C
@1GB
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHHHHHJJJJIIJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJJJJJJJJHHHHHFFF<@D@CDDDDDDDDDDDDDDDDCDDDDDDDDDDDDD
@1GC
CCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCT
+
CCCFFFFFHHHHHJJJIJJHIJJJJIJJJJJJJJJJJJJJJJJIHHHHFFFFDDEEDACDDDCDDDDEEEDDDDDDDCDD@BDBDDDDDDDDDDDDDDDDD
@1GD
GACTTCTGGTGCTCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCT
+
CCCFFFFFFDHFHJJIIJIJJJJHIIJJIJJJGGIGIJIJJIIJJJJJIIIIIIHIIJJJIJJJJJIJEIHIJJJJJJIJGHHHHHFFFFFDEEEEEECDD
@1GE
GAGAGTAACTGCTCTGATCATAACTAGTCAGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCC
+
@@<DDBDDHGHDFJJIJGJJJIJIJIJHGIIHIJEGFIIGHGIGIIJIJJJ?BFHDGIJ<CFGGIIJIGG;AEEC?BFFDFDC@BBCCDDDD=?BCDDDD
@1GF
GCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACC
+
=?1=D?DAD:C:DH><AFCEG@EEEH@+3AEHHGGH9FHEACC?9B6:BCGIB?0;/';5=66;77??7@B<;>6@C@CDDACC@C>CDDCA@:>>505
@1GG
GTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACCCTGCCATT
+
@@?DDDD;D?:1CCF>BGIE8FFE6BGF@>?D898=C)/>B;@49B>D@>>69:?@9(>9,,(,(5(::A3:4:A:AB::ABB>5<2?8?@@@<(2+:(4
@1GH
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
CC@FFFFFHHHHHJJJJJJIIJJJJJJJIJJIIJIJIIIJIJJHIIIIICHIIIJJJJJHHHHF;@DFFEEEEEEDDDDCDDDBCBDDDDFDDD:ACDEE
@1GI
GCGTTCTCTTTCAGCATCTTCACGGCCACCGTGGTGTACCCTGCTCCGCCTTTCAGATGGAAGGCCGTTGCCTTGACCACTTTTCCAAATTCGCCTTCTCC
+
?<=ABDDAHFFHHE<FF@FEHCHB@@AHII>DEHB??BDGEHHIIEIGGIIGHGGIIEHIHHFFEED>6=@CCACCCCC?ACAA@ADCCC@:?<BBBCCCC
@1GJ
CTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
B@CFFFFFHHHHHJJJJJIHIJJJJIJIIJJJIJJJIJJGHIJIIJJJJJIHIIJJJFGIIJJJJJHEHHGFFFFDECEEEDDD3=BDBDCDEDDCDDB
@1GK
CTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAG
+
?@@DADADHHGDHIIBBFEEEGHGGD?CFHDGGEGEGIIH@9D@DFHDBGHGIGAHGHAHGECDEAHECHBDECDFCACCCDDDDDED
@1GL
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTG
+
CC@FFFFFFHHHHJJJJJGHIJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFEEEEEEEBCDDDEEFEDDDDD
@1GM
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTT
+
@@?DDEADFHHHFIIIAHGEFGHGGIEFHIIIDBFHHH1:C1?H>DFG:DGGHIIIIHDHGICGGIIBBCFHG@FEFGIGCGH>CEHHEEBE?B@A3;>@C
@1GN
CCTGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTG
+
BCCFFFFFHHHHHIIJEHHHJJJJJIJIGIJJIIGHJJGGGIJJGFDDDDDDDDDDDDDFCDDDDDDDDDDDCCDDDDDBCDCCDDDDDDDDDDDDDDCDD
@1GO
CCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCA
+
@@<DDDDDHAHBDGB>EGEBFCGC<GE<60@GGE@DHIGEI@EGG?AEDDEBC@CC@BBB8=8;B8ACCC::ABCADA>>:>AC?C@B?<?ACAB<B?3
@1GP
CTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATAT
+
CCCFFFFFHHHHHJJJJCFHIJJEHIJIJJJJGIIIIIJJJIJIJJJHIJJIIJJJJIGHHJFHIJIJJJJH=AAEFFFFFDDDDDDCDDEDBDEDDEEDD
@1GQ
TGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTGTTCTGCTGGGGC
+
CCCFFFFFHHFFHFGFHHHGIJJJJJJJJJIJIIIJJIGIGIJJJJJJJJJJHIJIJIGGHEEHGHHHHHFFFFFFFEEAECEDDBDDBBCCECDDDCDDD
@1GR
CTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAAT
+
CCCFFDEDHHHGHGIGFFGIJIJJGIJJIIIGGJIJIGIIJJJIJIJJIIJIJJJIIIDD7<?CDDDBDDDBBDBCCDDDBCCDDCDDDDDDDDDDDDDDA
@1GS
ATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGG
+
CCCFFFFFHHHHHJIJJJHIJJJHIJJIJJJIJJJJIJIJJJIGGJJIIHIGHGJIJIIJHHHEFCEFFEDEEEEEDCDCDCDDDDDDDDDDCDDDDDDDD
@1GT
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@+=DDDFHHHGHGHIGIGGGGIFFBFHIIEGIFGGIHBFHIJIG>DIGHCHGIJHGBGIJJJJA6@EFFHHD@D@CEDDDD3;@B=CCCDDD>CBDDDDB
@1GU
GTTCGCTCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIJJJIJJJJJIJJJJJJIHGHIJHIIJJJIJJJJHHHHHEFFFFEEEEEDDDDDDDD
@1GV
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCC
+
@CCFFFFFHGHH@FHGJJIGIGEFGGGIIHGGGHGIJIIEHGCHIIGIGIJIIIIDIJGHGCDFDFFFEDDDBDB=CCCDCCDDBBDDDDDDDCCDDDDD?
@1GW
CCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGC
+
CCCFFFFFHHHHHJJIIEIHJJJJJJJJJJJJJJJJJJJJJIJIJJIJJJJJIJJJJJJJJJJJJJIJIJJJJGIJJJJJJHHHHHHFFFFFFDDDDDDD
@1GX
CGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCT
+
@@@DDDDFHGHHF>BFFGHGJJIIIBHIGHEDGIIEH>?FGIDDGIJIIIEGGHEGADBD@EF>=FHI?@D>D>AGBEHGHEDEFCDDFDCEEE;>CCDCC
@1GY
GTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTC
+
?@;DDDDAHFFA83EDE?F<AIE?EA@>HEGBBCB>FGCCFIIIIEHEGGGHGG>>>BBFCCCFB<@DEGGDCGGEH@>C=A=7;BDEC.;;A@@ACCECC
@1GZ
CTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTG
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJDHFFDEEEDDDDDDDDDDDDDDDDCDDEEEDEEEDDDDDDDDDDDDDDDDDDDDDDD?CDDDDDDDDDD@C
@1H0
CCCCAGCAGAACAAACCAAAGAAAAAGGAGAAAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGAGGAAAAGAAAAAAGAAAAGC
+
??8;B+:3AC>3:C>ED9C3A9C9AEEC@DD8C?DDE?09BDDBE;8=BC;7@A<?(.77(7;).6;@1;>;?A??255(,282>>>><33<5;<???A<
@1H1
GTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACT
+
@@@?DDFFHHFHGDGGGIIGGECIGBADEC@AEGHGIIIHBBCFHI:9?BD8?D>CDEGA>HAGIGIIIGCHHHHHB@CDEFDEC6>CCD?AC@C@CCCD:
@1H2
CTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCC
+
CCCFFDDFGHHHHJJJJJJJJJJJJJIJJIIIJJJIJIFHHIJJJIJHHHGHHFFFFDDCEDDDBBDDDDDDDDDDDEED:ACDDEDEEEDDDDDDDDDD
@1H3
GGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
C@CFFFFFHHHHDGHHIJJJJJJJHJIIGJJJJIHIIIIJJJIIIJJJJJJJJIIJIAHEEHFFCEFEECCE?@C@CDACCC@CCCCBDD9ACDDCCCDD
@1H4
GGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTT
+
CCCFFFFFHHHHHJJIJIJJJJICHHJJJJJJJJJIIJFHIJJJIIJJJJJJJIHIJJIJIJJJIJJJJJJJJIHHHHHHFFF?ACBCDDDCDEEDDDEED
@1H5
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
BCCFDDFFHHHHHJJJHHJAFHGHIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFDDDDDCDDDCDCCDEEEEEDDDDCDDD
@1H6
GCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGT
+
@@@DDDFFHHFHABGEHIG3<@FGI@B>B?B:B<GEDGGI?DEDGCFCGIII<AF=FH4CGGIHHFHGFBDC>A:ABBBBBBCBBACDCCCCB75<<B9<C
@1H7
CTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGC
+
@B@DFFDDDFHHHJJIGIJJIIJGGIGIJJJIIJIJIIIJJIJGGGFFDDDDDDDCDDDB@DBDCCCD>A@CAC>@ACCDDDDDDDDDDDDDDDDBDCCDC
@1H8
CTGTCATCTCCCCACATGGCTCCTGAAGAGCCTTCCCAGGGCACTGCTAAAGGCTCCTTCCCTTGAGGAAGCACTCCACGACCCCCTGTTTGTTGTCCTTT
+
?:?A1=DDHHFBDGDHIIIEGEB>G@BGH8C?9??9C??6DDHE@C99BGC=88=CHGIIGIEHCHE@A6..;7;636;;'3'35'5(+:>C29?344:>:
@1H9
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
CCCFFFFFFHHHHJIFIJJJJJJJIIJJIIHIIJJJIGHHIHFHIGHIIGIIIJBFFICGIJ;CEHACHFEFF;?CCECCDDDDDDDDDDDDDDD>BDDDD
@1HA
ATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCAT
+
CCCFFFFFHHHHHIIJJJJJJJJJJIIGIGIJJJJJJJJJJJJJIJJIIJJJDDDDDDDDCD@CDCCDDEDDDDDDDDBDDDDDDDDDEDDDDDDDDDDDE
@1HB
TGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGCTGTGAAGAGGGCT
+
@@@FFFDDHHHHHJIAEBBGHIJIEFHIHBGDIIIJJJDFFGBF6BBFFIEGHIGIDGGDFCA.=EDECHEE?=@.;7ADBCEE3;=@AD<>CD::ABBBD
@1HC
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
B@@DFDDDHHHGHJIJIJJIJJJIIJIJIIIJIJGGIJJJJIJJJJJJIGIIJGHEHGIEHIGIIGHHEEEHFCDFFFFDDB;@DDBDCCCDDACDDDDDD
@1HD
GTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGG
+
CC@FFFFFFFGFH?@BDDDDD@CCCDDDCDDDDDDDDDB<@6?BBBDDDEDDDCCDCCDCCADCDCBD@BBDDDB@?9@CCC?A>CC@>C@CCCDDCDABD
@1HE
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
@?@DDBDDF8?AB?CBCGD@BBDBBFHCGIIEIGDBBDHCHIIIHHGDHG?AFBEA<>>B>@CB@@?<@8>BCC<-0098A:44:>?C33::>@CDCCC
@1HF
CGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGAT
+
@@@DD<BD>?D;FFHE@FHH?@::<CG?C<?FACC9B;A@@DA9?F(8C<;=F6@=C)7=EB3??6?@BCCCCCB;;@CBB?@?@,:(8<48??(:8?9&)
@1HG
TGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGT
+
@@@FFFFFHHFHAHGIGGIIJIJJJJJJJIDHGHIJJGGCEGHHGHGIHIIJIJIJEHFHGIJGGIIHHHHFFBEFCEECACA@CDDDD8?BD9@CDDCDC
@1HH
CGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAGCC
+
;@<DB@??:2<AAAC?C@AI?<@ACG?E?CEB;FFD?80BB?B98?DDA8DFF>@7=@FBE;67=C==?BD>;?39@7?A;;>355:>::;55@:4+(+3
@1HI
CTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
@CCFFFFFGGDCDHHIIIEGEFHGHEHGEHIIIIIGBFGII@GCDHGI@?FHEH9ABED@A?=A@BDDDDDC3;>B<ACCCCAC?CDDDDCCA>ACCCC4>
@1HJ
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHFHHHJJJJJJJJJJJJGIJGHJFIJJJJJIJIJJJIIIGIIIIIIJJHHHFFFEDEEDEDDDDDDDDCCDDEDEEACCDDDCDDBDDDDDDB
@1HK
ACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATG
+
CCCFFFFFGGGGFIIIJJJJIJIJJJJIHIJIJJJJJIHIIHJIIHJJIIJJJJJFIJIGDHHHCEFDFFFFEFEEDCEDCDD5?CBDDCCDDDDDDDDDC
@1HL
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@@DDDDBF?FFDBABCCABAGEADFHH9FHEGC@HGG>GBAF<9?FG@89BCHGHAD:C;DCD@EHC7?9;73);AA:;@ACCCB?<AB<::3@C>CA::
@1HM
GAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAAT
+
CCCFFFFFFHHHGIIIJIIGEGGIJJJEIJJJJJJIJEHIIEEDFFEEEEBDDDDDCC:@@:ACCDDDEDCDDDDDDDDDDCDDBDDDBCCCACDCCDDDC
@1HN
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@@FFFFFGHFHDGGGGDHGGEGEHIFGIJIJIIIGGBFHIGHIJIGIG<DHGGCFHEGGHHGGIGHHFE>CC>C;@DDCDD'3;B8@CCDA@:@ABDBB<
@1HO
GCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGTATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGAGGCAGCTAGGCACTTCTGAGTCATATG
+
@@@?A=AD,=:<2<<A?FE33A9G@F<9<9ACA111*:?D9<;DABDD8?F940***9BAFEFDGD@)7@A7@)5?(;B1;:@(6>2555(-5>,(53(;;
@1HP
CTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAAAAAGTGTT
+
B@CD=DEFHHHHHJJJIIIJIIIJJJJGICHIJIJIIIJJJGIGHIFIIIJGJJJIJIIHJJJGGIGIGIIJJJGIIGIJFDEDCCCDDAC@CDDDDCC>B
@1HQ
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
@@@DADDDHH?A:EBGE>HHDAHEI@@;ECHE?:*CGA08@09B8B/B;@/5@G>?HH;)77@;>669A:(,;;:C::>:@5;5@@:C:C>>::::AACC
@1HR
AAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTT
+
???;;DDBA=CD7C:CDA+<CEEE>>FD@A+AFEAE<9D@1?B@DCEDDCDDCDDICD>DCD?C:;@DD@=;>>>(3(-;AA?????;93:>>AAAAAA>(
@1HS
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHIGIJJJJJJIIJJJJ?DFIIIJJIJGJGGIIIJJIIJIJJEIJGHHFFFEDEEEEDDDDCDDDCDDDEDEDCCDDDDCCDDDDDDDDB
@1HT
CAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCT
+
CCCFFFFFHHHHHJJIJJJJJIJIJJJIJJJJJJJJJJJJJJIJJJJIJJJJJJJIJIJJCHGIJJIJJHHFDDDDDDDDDDDDDDEEDDCEEDDEDEDDD
@1HU
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@CCFFFFFFHFFGJGIIJHIIJIJJGGGIJJG?FFHIIGIIJCGGIHGEHIJJIIIIJIJGIGIIJJJHGHHHFFACCEAAABBDDCDDCDDCDDDA?@B+
@1HV
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFFFDDHFHHHJIIIGIHHHIJJJJJJJJJIJIJJJJJIJIJJJJJIJIIIJI=FHGGH=EHHHHDCDFFFEEECCD9ACCDDDCCDDCDBDDDCDDC
@1HW
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
B@CFDDFFHHHHHJIJGHIHHIFHHIIJIJJJJJJIIHIJJJJJJJJJIIHHIJGGJFJGHIJEIHGGHHHHFFDDBBDDDDDCD@ACCDEEEDDDDCDDC
@1HX
TTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJIJJJJJJJIJIIJJJIJJJJJJJJJJJJJJJJHHHHHHFFFFFFEEEEEEFEED
@1HY
CACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTA
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJJIJJDHIJJJJJJIJIJJJJHGHHGHHFFFFFEDEEEEEDDDDDEDDDBDDDE
@1HZ
CTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAA
+
@@@DFFFFHG>FFGHIBHCHGIJFJJCHIJIIGIBGIGGJJJGHFHDHJJIIJJEIJJH8?DCDBA6>?AC5>CDDDEEDDCDDCDDDDDCDCCDDDDD
@1I0
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTT
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJIIJJJJJJIIJJHIJJJJIJJGIIJIJJJJIJH?EHHHFFFFFFEEEEDEDDDDDDDDDFDDDACDDEEDDDDD
@1I1
CTTCAGCACCCCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATG
+
@@@DDD>BFFHFFGGIGIB@DFHHHEHFGGHGBHEGHIIGEHDCF9?FFHIGEHGEGBGHGGGIIGCGGIGAEHIIHFHHFFD?DBD@ACCB,;CCDDCDC
@1I2
CTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGT
+
@@CFFFFFBHHHFIIJJIJIJIJEFHGJJGEGHICCGIIGIIIIGHIIGHHIJJIIIGIEIGFFFGGHGHHEECHFEFFFDEFEDDCE@BB@CCCDDCCC5
@1I3
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJJGHIJJHIJJGHIJJGIJJJJJJJIIJJJIJJJJIJJJJIJJJHHHHHHFFFDDEDDCCDDDDDDEDEDDDDDDDDCDDCD
@1I4
ATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGAT
+
@CCFFFFFGDHHGGGGHDIFFEHIIEHIIJJJGGIGDHGCHHGG=AEHIHHHIHHGHHHFF@BFFEECC@CCCCDDDDCCD@C@BBD?CDCDDCDCCBDBC
@1I5
CCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGGCCGTCATTTTGAACTCCCCGTTGGTC
+
??<DD@D8<<::CEE:EA<AA?2CFIIDE;)3C:6BDBBDE<8?06684--?D;@@<<?9;>>?<?<:>5,3;;&595&028>:::>A>A>><)5)8+(+:
@1I6
CTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGG
+
?=:D;A;BADAFF@<:AEE<DAGFGC3EFHCGBDEHEEHG<FEBDGAHDDFC/?@?CHFCFHG@AAHC=?CECHBCC3?>BC;(;(;>>A@A=C??@<=?
@1I7
TCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTC
+
CCCFFFFFHHHHGJIJJJJJJJJJJJJJIJJIIIHIJJJJJJJIJIIIJFHHIIIIJJJIJIHIJJJJJIJEHIGIJIIIJJGHIGI=CEHGHHHEFFFFF
@1I8
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
@@@DD?BDDFB<C@FGHEBFFGCCH@A?9AC??GHEHGGGC*??BBHGIIGGGIDHHIGFID>=FA@FHIFGEH=?DEECC@CCCCA@CC>A5;<<??B:@
@1I9
CTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTC
+
CCCFFFEEFBDFFGIJGGIFHCHHIAFIIHIIII>AGIGHIIGGHGGIGIHHIGGHGIHIIGBEHJJJIJIIJGIGCEHGDEHHHGHHHEEFDFFFCEEE
@1IA
TGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGC
+
CCCFFDEFGHHHHJJJJJEIGHIJJJIGIIIJHIJJJJDIJGHIJJJIIJIHGIJGIIIIIGHFHHHFFFFFFFEEDEEDDDDDDBDD@@BDBDDDDECDC
@1IB
CTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTTCT
+
?@@DDDDDBFFFDG;4CFHFEEFGHGGFH@GIGII:DCGGGIHBGGHB@DGGEIGI=@C@>AAHEC;;?@D>CCCCCCCCCCC>(=:;>CCCCCCCCBBCC
@1IC
GCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGT
+
CCCFFFFFHHGHHIJJIJJJJJIJGJJJJJJJJJJJJJIFIJGIJJIIIIIGGHIJIIJJIJCHHIJIJGIHHHGFFFFFFEDDDDDCDDDDBDCCDDDD>
@1ID
CGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTG
+
@@@ADDDAHF<:CB<FGDHBEF:F@HFGGICHIGDFHIGHBHIEGHHCGEEHH<B;FBGF9@C2)>@3@CC3?.=@DEE>>;@B,:A@CCCCCBBBBB?@B
@1IE
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTC
+
B@@DDFFFHHHHGJJJJJJJJJJJJJJJJJJJJJJJJJIJJHIJJJJJJIJJJJJJJHHIHHHHHFFFEEEEEDDDDDCEFDEDDDDDDDDDDDDDDDDED
@1IF
GGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTG
+
BCBFFFFFHHHHHJJJJJICJIJHIJJJJJJJJIIIIGJEHIJIIJJIJJIJHIJHBHFDDDDDDDDDEEEDDDEDDDDDDDDDD>@BCDDDDDDDDDD
@1IG
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJJJJJJJJJHHIJJJJJIJJJJJJJIDHHIIIJJBGHJGJJJJJJEHGHHHHFFFFFDEDDEDDDDDBBDDDDDDDDDCCDDDDDDD
@1IH
ATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAAC
+
?;??DAADDDADD:)@1<CE@4<?AE8E3???CBCDDEI33@</?/7C<BCCCCAC@CCDDCDDCD@9;;>AA@=????:>AA=?5(>>>>AA<>.(0<>A
@1II
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
CCCFFFFDHHHHHJJJJJJJJJHHHJJJJJJJJJJJJIIJJJJJJJJJJJJJHIJJJJJJJJJJJIJJJJJJIJHHHHHHFF@EDBDDDDDDEEDDDEEDD
@1IJ
CTGCAACTCGGTTTTCCGGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAAT
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJHHHFFFFFEEEEEEEDDDDEEEDDDDDDDEEEEDDDDDDDDE
@1IK
CTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGG
+
CCCFFFEFHHHHHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJIJJJJIJJJJJIJJHHHFFFFFEEEEEEEDDDDDDDDDD
@1IL
GTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTG
+
CCCFFFFFFHHHGFHGEGH@EGHHEFFHGEHIJHGIIJHGHFFB>ADD@CDAACCDACCACDDCDDDDDD@CCDDDDCCDBDDDCCCCDCDDCDCCDBBD
@1IM
GTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAAC
+
@@CFDFFFHHHHGJJJJJJJJJJIJJJFHIIJJJJJJJJJJJJJJJJJIIJEHIJJJJIJIJJJJJJJIJIHHHHHHFFFFFFCCCEEEDDDDDEDDDDDB
@1IN
AGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTG
+
@@@DDDFFGHDDFEFHGHIJEGBHCGGFHIIIJIGIEHHJDHHJJIIJIIGGDIJJJEFIA@CECEHIIGFHEHHEADB?=BDEDDDDDD5>BD@CDD?CC
@1IO
AACAGAACTGTGTTTTGATGTTAACAAATTGTACGAACACAAGACTTAAGAAATAAGAGCAGATGCTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTC
+
@@?DDDDDHDFBCCGGC=F@HG?AFFHGHIHEHCHIGIEHIEGEAGHIDIGGEHEHGFH9@CGGHIIHC;CC7=C?BE?DA>C@@CCCCCC?CB?ACCCC5
@1IP
GGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAA
+
BC@DFFFFHHHHHJJJJJJJJJJJJJHHHHIJIJJJJJJJIJJJJJGIJJIIJJJHJJHIJIJJIJIJJJJJJEHHHHHFFFFFFFEEEEEEEBDDDED
@1IQ
CTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACA
+
@CCFFFFFHHHHHJJJJIJJJIJJJIJJJJIIIIJJJIIJJJIIIJIIIJJJJGHHIIIJJIBHHGJJIJJJJIIHHIJJGHHHGHFFEFEDDDDDDDDD
@1IR
AATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCC
+
@@@FFDFFHHDFAGEGHCFGACDCHGEFGIIIAHGIIGJGHHHFFFD@CC9?BBBDDEEDDCDCCAACAACDDDCDDDCCCDCCDCCB@<ADDDDDDDDDD
@1IS
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
@@@D1ADDF??<CAEBHIFDGGE<FHECE@FE<FH?DEA<?G?D9BFGGIBF>BFEGGBB@@C;=B:(=A?DCDB;@=,;@CCA@ACCC@BCBBCCC<@B)
@1IT
GGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGAT
+
BCCDDFFFHHHHFIIJJGGIJJHHIIIHIIHHGIJGDHCGGGHIIJIIDGHJJHEEGIGBHFHCEEHHHEFDD>.6;?CDCDCDCBACACCDDDCDDCDAC
@1IU
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
@@@DDEFFHHHGHEGHIIJJIIIIIIIIGDFGGHIIGG?@FDFGIIBFG>@DHIHGEEEHGECBFFDDDDDBC>>CCCDDDDACCBDCACADEDDDDDDC
@1IV
NTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGG
+
#11==:BA?DCFDEEBEBADBB4C+9A9?>?DF>D??<?4?4??<BDE?*B@F(8@F8<C8=A476'5:?);.;;>(((>6@?(5;;;:>?;((55>5:?B
@1IW
GGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCC
+
@@@;BDD>D?FDF>E<2AFCBFFDFDEFAFEBCGC9CFGBGFFEFB;8?D@FB78-;C@17=>E7?C@DD7;;.;?'5;5;A:@@@>B?B@55:AB>A99>
@1IX
CTGCTGCACTGGGCTCCCGGGAAGCAGGGGTTGGATAAACAGCCATCCACGGGGCAGCTCCTCTTGTTGCACATCTGACGCTCCTGCACATCCCCCACGC
+
????;=AAD?2C3CE?EAF:8::11:18)008D.8)=B8CE)8@@)@@@?D/9@/;>>5::(,>(:A:5A:>3+:+4>A--&55(:49>AA:3<<>;?09
@1IY
TGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTG
+
CCCFFFFFHHHHHJGIJJJJJJJJHIJJJJJIJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHGHHFFDDDDDDDDDDDDDDDDCDDDD
@1IZ
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGG
+
@@<D;=DDHAB?:;EHEBABFHAFCFH<CD?FGGEEGEH@:CGDDHIIA8FD976A7;CGACEHA==?A;?777;B@;>C36;C6>3>>CC>35>@@39;9
@1J0
CTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCT
+
@@@DDADDHH>CFGIGGI>D@FFBHGCCHFHC@FHIG9HHHGII:D??BB?FGGFGHGIIIIIIIGI@@GGAEHEBDBBCECDCCCCA;@C@;?-:@@<A>
@1J1
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTCGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGG
+
;?@DDDBBFHFHFIGIG<E?GGGEI@FDHIIIIDIBFHB*87DHCFGE3CHGHIIIDG)@4@7?EEE>?BDCCCCD;AA@CCBB';;:@4@@C(>AC>+:?
@1J2
GCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGC
+
@@@DDDDDHDFAFGGGGEHHHII<AFGIGI@HGE@FGGGHIIIHIBFHGGDGFHIHHIIEHCHIIIIIDCACH7==B(6=B;>CB?AB,<AACACACACBB
@1J3
GAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTC
+
?@?D?A??FHD?DEH<:CHI;AF<<A:CH49<<CFD?1:9C@9FFBDF<9DD@DGI@@?8FG<88B==@@@@6.7=@7?AE>=E>B;C@;6;66>>@;;AC
@1J4
CTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATC
+
@@@FFFFFHGHDHJIHGJGGIJIJJJJGGHHIIIGGHHIIIJJFBGFGIJJJJJIJJJJIGHJICEGI@FG@=CDGGGGHEEHGH>??DDEEEEECDCCC
@1J5
CCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCC
+
@C@FFFFFHHGHHDFGIJJIIIJIJGIGEHJIIJJJHIJJJJGHGFFFFFEFBDDDDDCDDCDBBBBDBDDDDCCDDCCDDDCCCCDDDCCBCBDD??CDD
@1J6
GCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
CCCFFFFFHHHHHJIIIIJIDDDDDDDDDD@CCCDDEEDDDDCDDD?BDDDDDDDDEDDDDDDDDDDDEDDDDBB9>BDDDDCDDDDCDDBDDCCDCCAC
@1J7
CTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAA
+
?@@?BDDFHGHHHIEEHIIIIG>GGHEGIGGE9DFHI@GIDFECGCHE>CCACF@EHIGHHB@@?3>@@CECBBC>;;:@AC@CCCECCCC>CCCCCBCC
@1J8
CCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTTTCTCCAGGACCCAGGGAAATGTTGCCCCTGGAGCCCAGTCCCTGGCAGCCTTCCTG
+
?@@DD?DD;FH?BEFF@GCFA?E@)2<1??FHI810:?FBFHF99?<BFFH88;CHAF@EHIHHH;=?7?BC?6?;;;;@BB9C>C@::9<3888?@:>:C
@1J9
AGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CC@DFFFDHHHGHJJJJFBFFHIJIJJJJJIGDFHIIJJIJIJIJJJJJJJJIJGGIJIJIHGHHHHHHFFFFFDEEE@CCD@CDD5>BDDDDDDDD8?C
@1JA
ATGGGGAGCATGGTGTGTCCTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAAC
+
@@@DDA;)<CFDFFIFFDECH@;A;?EAGF?DGFEEBGFFF6@?9BC8<=>FFFCC>@FAEI>CEEDDD=;AA???B9@@;;@A(,9A>BBB>@<B?5:39
@1JB
CTCCTGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@@DDDADBCFBAHGGIAH@DHGEEHI@FHIEHIGIIIEEDHIGCFHHFHCFAFDHDHIDHHG@C>?CB@@@CCCCB?258@>:CCCCCCCC@BB<B5@?C
@1JC
TCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
<@@DDD?DHFH>FF:?BA<CFBDEHIDE?FHFAH9CGBH?0?0BFBBE2B89BB@BC=F>@7=B;-=?C7?@B7;;;=CCCC@;@ACBBCBBCCC8<20
@1JD
CCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGGATAGGTG
+
CCCFFFFFHFHHGGGEHGGHCGGHIJJJGGIIEGDHHIJJJJIIJJJIJIFHGHDEEFFCCEECDDDDDD@ACDDDDCDDDDDDDCDDDDDDDDDDDDD>C
@1JE
CGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGC
+
@@?DDFFFHHDHGHIIBHIGIIHHH@CDFFCDDEECACCDDABCCD>CCDCDDCDDCCCCDDDDDDDDD>CBBBCACCDDDDDCBCCDCCCCDDCCDDED>
@1JF
CTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGG
+
?@?;DDDDFHF?DCDCGFCH;3@CFCFGHABA>GDABD>AFE???B?>:?9CBC?;8+7;BBB????0;B<?@>599@<CB3>@>@@AC@>A@>::3<
@1JG
GCCGCCTAGCCAAGAATGTCCAGGTAGATTGGGGTGGCCTTCCCCAAAGCATGGAGGATTTTGTAGATCTCCTTGATGTTCAACCGCTGCTGTGGTTCCCT
+
@@@DDFDDDDFDHGHGIHEGHHIGBHHGIIIIG6?FGHIIIIIJFIGGFEIGGJIGDEEEFEFBBEEECCCCDDCACCDCCCDDDDB><@CCACDA?CCDD
@1JH
CTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGAT
+
@@CDDADDFBFHHIEHDBEFADAGGAGHE?CGHIIIGIEFGEHGGGHGFFDEH@HGGHIIIGIGHIGC@E==@AHEEHHEFDFEFFEEEC6>CC@CCC>C
@1JI
CACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
BCCFFFFFHGHHHJJJJJJJJJJJIJIJJJJIHIJJJIJJIIJJJJIJJJIJJJHGFFFEECEEEDDCDDBDDDDDDDDDDDDDDDDDDDDDDDDDDCDD
@1JJ
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTT
+
CCCFFFFFHHHHHJJFGIIJIJJIIJJFHJIIJJJJJIJGGIJJG<FHHIIJIJIJJJJH=CEFHFFFDBEEDDEACCBBDDDDDDDDDDCCDDEEDDDDD
@1JK
GCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
BCCFFFFFHHHHHJIJJJJIJJJJJJCDH@GGJJIJIJJJJJIJJIJJJJJIGJJHHHFFFFDEEECCDDCCDDDDDDEEEECDDDDDDDCDDDDDDDB
@1JL
GTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGG
+
C@@FFFEEHFHHHEHGCGGCGHHHIJJJJIAFHHHHHJJJIIIIGICFGGGGJIGIIHEHHHHDDEEFACCCC???BBBDDCDDDCCDCDDDA<?BDDA:>
@1JM
GTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGAT
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJJJHHHHHFFFFFFEECEEDDDDEDDDDDDDDDDDDDDDDDDDD
@1JN
ATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCT
+
CCCFFDBFFHFDFGGGIJIJJCFHIEIJJIIJJIJIIIJHGJJJCEEFHF?BBCC@>CEDCCCCDDDDDDACCDDEDCDDDDDCDCDDDDDDDDDDB5>BD
@1JO
TTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTG
+
:=:===D??F:AAA<2AA<<<8@FGII>GG1:1CD??DF:????9?90B?A888C787C...77==5/56;>6;@9/=?>:;5@:4:@B44444@BA:@>:
@1JP
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGGGCATATCCTTGAGTGGGCTGGG
+
@C@FFFFFFHFFFHIHGHIGIIJJIIHGIJJIJGHIIIJFGDEGIIGIIGJJIJJJJJJJIJJGIJJJJIJ7=EDDFF)>AEEECDEEDD@AACDDCDBDB
@1JQ
CTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGC
+
CCCFFFFFFHHFHJJJIJJGIJJJIEHIGIIIGGIJI@DHIJJIIHIJJJJJJJGHFFFDDDDBDDDDDDCDDDEDBCCDDDBDDDDDBDDDDDDDDDDDD
@1JR
CGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGT
+
@C@FFFFFHHHGHIJIJGIGGGFHGIIJJJJIJIIIIJ9DFIGGIGGHIBBBEA>;>@B@CCEDDA@CDDCDDDACCBB?>DBBBBBBCCDACC?@CCDDA
@1JS
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJIJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJIJIHHHHHFFFFDFFDDD>BDDBCDDEDDCDDDDDDD
@1JT
CTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGT
+
CCCFFFFFHFHHHHIFGIJJJJJIJJJJJIGIHJJJJJJJJIJJJJJJJJJJJJJJGIIIIJIIJJHFCDDDDDDDCDCCDCDDEEDDDDCCDDDDDDDDD
@1JU
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFDFDFFFDHGFHJJIHIIEGH@?DHGHEHBGHIHIIHEGGBCHIJEHGGHGABDDDDD@CAAECDCCC?CCDCDDDCACCDCCDCDBACDDCDDDDD
@1JV
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@@@DDDD?D<CDDFHGIAHGGHHHAB@:CECGCGGG@?BDGHBGIIIIIGGEF@F@AADA@3AE?AEDBBCC>=>CCC@CCAD>>C@AC@>CCCC33::@C
@1JW
GAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACT
+
@CCFFFFFHHHHDGHGIIJIGGGIIJJJJJJIJJJIIIIJIJIJIJJJJJJJJIHHHHGADFFFDEFEEEEDDDDDDCDDEEDDCDDDDDDDEDDDADCDE
@1JX
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@BBFFFFFHHHHHIJJJJEGHIHGIJJJJ?HHIIJJJJJIJJJJJJJJIJJJJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDDDDDBDDDDDDD
@1JY
CCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGC
+
@?@DDFFFBDDHHFHH@?DG>F@HHGEDHCHIIIIIIHIIGIIIIDGHHHA=AHED@D@CCCCCEEECCCACCCCCCECCCCCC:ACCCCCCCCCCDCDCC
@1JZ
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
@??DDFEDDDFDFHHDGIGFAGGHICECBDFHGDHH@FHDGIJIA8CCDHIGIEEHFE><A>BDACC>CC?CDB@CCDCCDDCDCCACABDDDC??A::>C
@1K0
TCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGTAATGCACTCAATGACCTCCGT
+
@@@DDAD;<DFDHIII@FDEGHIBHHHIIEIDHGIIIGBDEHIGBEHEGIIGCHGHDEC>@@BCCCBBBBB;BBBCCCB8>?ACC>C@CCCC>CCCCCBBA
@1K1
GCTTGGGAAGCTGCATGCGCAGGTTCTCCAGCTGCAGGTTCTGGGAGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTGCAGGGAGTAGGCGGTG
+
?1::B;AD3DD:+2<?E:C:?881?*:C<1CDDE>E9D0B93?*?((<-6))7).7@C77@C6?)).@D93>?8,<((5(:5>+(+(4(&()8((((05&&
@1K2
TGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGAC
+
?@1?DDDB?DBBFFF@@E9A;CFFCGC<DE@FGFE8BG3?DF@FFABBFCF<DEEB?CEDBDDDDCC;,;>B>@BBB:::@BBBA:<0<>9(8<B88<>@3
@1K3
TAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
BCCFFFFFHHHHHGHIHJJHIIJJJIJJJJJIJJFHIHIJJJJJJJIJJJGJHIJJJJIJJJHHHHFFFFDDEEDDDDB@CDDDDDDDDDDDDD?CDDCD>
@1K4
CGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATT
+
CCCFFFFFHHGFFGIJJJIJIIHGGGJJJGIIIIFHJIFHIJJJHHHFEFDDEEDEEEBDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDEDEEE
@1K5
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGCCTGAGCTGCATAGG
+
@@<DDDD?=,=AFBG@:8)<<CAA9CF11?*:FFIIE?)0*9DFBDBAFBD8).=C).=;@?A3AC);68;;(;(5>>>AA>(;;A(5<5,5>:A((++:3
@1K6
TTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTG
+
@@<DDD=BFACFFHIIIICEGGIE>FHGFGGII@AFIGG?FGEHGG@BDAB;A;DEG;C=EEB;;B;@A@@C6@>=AC@C?@BBCCCD@A5:>?CACCC:@
@1K7
CTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACT
+
?;8=BDDABBFB<??<:CIAD:C:<C<9?F>?EGI<<?<DF<?B4:9:BBB<??/<;==;877=E77.-.?7377@D7;.6>>BCAAB>ABB>>AB@A:
@1K8
GTCGGTTTCTTTATGTTATAACATGTCTGAGGGTCCTAATTAAAATCTATTAAACTAACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGT
+
?1:BD@@:D<DDBEB<<CFEEAFB@FDEFIE):1?DD@??DDBD?BDCDDB@D<DEIEE@>@CE=CCAC;=A:=@>A=CCDCDDDDDEDDAA@A@?;??AA
@1K9
TCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAG
+
@?@A=;AB>=CADGEGA@?CFHHGIECFHHIGAGHGGHGIGIGCHIB<FHDDDF=B@FEGG@F==CGCHEC;;?@CCDCC@
@1KA
GGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTG
+
CCCFFFFFHHHHHJHIIJJJJJJJJIJJJJJJIJJJJJJDGIIIIJJIIJJIJJJJJJJJJJIIIJJJJHHHHHFEFFFDEECEEDEDDDDEDCDCDDDED
@1KB
GGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGG
+
?@:BDADDBFBF>GAEHGIDIIIIIDGHHDDHGFIGHIIIIIGGIIIIGD/?ABDBDDDBBDDCCDACCDCACDDDDD@DDBD@@BBDB@B@BBB>CBB@D
@1KC
GTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCC
+
@@@DDFFE?HFBBHGIB?>CHCIGEH?CFEHEIIGHIEGEGB?GBGGIBFEBFHCGIIGHHDGECCHIII;@DEHEIIIGGGECHECC;BE>>ACCCEDD
@1KD
CCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGG
+
CCCFFFFFHHHHHICGHIIJJJHIIGGIJJJJJJJJJJIJIJJJIIIIIJJJJIHHHHHHFFFFFEEEEDEEEDDDDDDDDDDDDDDDDDCDDDCDCDEDD
@1KE
CCTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCTCTCCTCT
+
CC@FDFFDHHDHGGHBHHFFFHGIGCGGEHGIIIFEGGIGIJ@HGGGGEGHBCHHIHHHGHHFFFFFFEEEDACCBCDCDDDDDDDDDDDDDDDDDDDCDC
@1KF
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAAT
+
@@@FDFFFHHGHHJJIJGIHJJJIIIIJGJCIGIJIIIIIGIIGGICHBGIAGGGHIJJEHFA>EHECEDFEFEEDC:@CACCCDDDDEDDDDDDDDCDDE
@1KG
CTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAAT
+
CCCFFEFFHHHHGJJJGIIIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJIJJJJJHHHGFHHFFFFFFEE
@1KH
CTCAGGGCCCAGGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGT
+
@@CFDDADHHDDHDHEDHHIHGEEEIIIDGIEGIIJIGGGGGIGFHIEGGEHIDFHF@DHGICGGGGIGHHFFFD>ACA?@@BDCA@DCCB<@B<A@BD?>
@1KI
CAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGC
+
@@?DDBDDD?FFDIGF:?CHHHIIEGGGIEGIAEGHGIIIIHHIGDHGHGHIIIIGGGII@BABF=CDGIIIIIIIFGIHEHHC:@DEEEECCCDC6;?CC
@1KJ
CTGACATCAGTGGGCTGTCCATAGGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
CCCDDFFDHGHHHJIIJJIJIIJGJIIGGHJJIJIJIIJG?FHHIIIJGIIGFHIGIIEHHGHHFFDFFDECC,>CDEACCCDDDDCDEDDBDDDDCCCD
@1KK
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFGHHH>GIJJJIJJJJJIIIIJIIJJIJJJJJJJJIJGIJJJJJJJJIIIIJJJJJJIIJHHHHGFDFFFFFDDDBBDD;CCDEDDCDDDDDDD
@1KL
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGCCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
?1?B10A+CFBBC>FA:<C6C<8C><?1?;CF*0?BF<G<D?8*B9?C98F61))7)))777(',,,(55=((,(,8(83@:@::(4>(((2()))+2(+3
@1KM
GTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTG
+
@@?DFFFFHHHGHJIJJJJJIIJJJIJBHHIJGHIGIJJJJJJIJJGHIIJFHJJIIIJJJIJJCGIGHEIGGGIJIJIIIIJJGHHGEFFFFFDD>B=AC
@1KN
CTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGG
+
@@@DFFFDHHGHFGGIGEGBFHGGEIGJHIBHFGGGEGHJEIAGHCHICHGHEEHGEEHECHGFF<BBCDDB?;ACCCCDBBC@CDDDCDDCCDDCCEDCD
@1KO
CAACATACTCCTTCACAGCTTCTGGTGGGATCTCCTTGGGTGCCTCAGGAGCAGGAGGTCTCTGGGCTTTACGCTGACGCCGGCGGGGGGCCCGTGTCTTG
+
@@1DDEDDDHHHHGJIGIJGGIJGICFGEHCEEGFHGHJHGHIJJJJIIIGIJIIGHG@EGIGFGHGGFFFFCDD:BD??BBBBBD>>BDDDDB59+2>C:
@1KP
TTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCAATATTCAAATCATGGTGTGCTGAC
+
@@@BDDEFHHHGDHGGHIJJIJIGGHIEHHIIGGEGIJIJJIHIIIIIIIFIIIIJJIJJIJIIJICIJGGIEEIJJJGGIJIIJJJIJHHHFHBEFFFFC
@1KQ
GGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCC
+
@<?DDDDDFB?DFH;GG>HHDHHECCGGIAGIIIGGCHI>GGEGII9D9?D@FHGGG8=<BHIDG@DEGA;CCECE>CDE5;?:B=;=2:@D:8??>CCC
@1KR
CTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGT
+
@@@DFBDDFHHGDFFHGIJJIGHJJJIGCEGIIIDGGCHHHIGHDAGHG>FDGHCFHGID;FCGGCHIEHGIJIGIGHHFHBEDEECCEEEECCA;@CCD@
@1KS
CGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGAC
+
@@@DDDDDHFHHFAEHD@HCCHIFFGIFFDHIHEHIIIHIGHIIIJH<D99DGFCABF=CF;CH@C>@EEHHHCEFF;BCD55?B@CCBABD8?CDDCC@>
@1KT
CTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAA
+
@CCFFFFFHHHHHJJJJIIJJJJJJIJIIIJJGHIIIIJJJJJJJJJJIGHIJJIIIIIJJJJIJIJJFHIGGHIJJJJHHHHEDFFDFFEEEEEEED
@1KU
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
CBCFFFEFHHFHHJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJGHIJJJJJJIGGHHHFFFFFEDEEEEDDDDDDDDDDABD<BD@D
@1KV
CCATTCCAGCCTGTGTTCCATTGAGTTCCACAGGCACACCTGCCTGTCCTGAGCACATGTCAAGAGCAAATCTTTGAAGGGATGTGTGGCAAGACCCCAA
+
CCCFFFFFGHHHHIIIJJJIJIJIJIIIJJIJIJJIJIJJIJIJIJIIHIJJJIGIJJJJJJJIIJJIJJJJGJHHFHFHFFFDEE@CDDDDDDDDDBDD
@1KW
GCGGGGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCC
+
CCCFFFD@FHHGHJJJIJIIIJIJJJIIFIIJJIIIIJJIJJJIJJJHHHH=7=;@DFDDCDBBDDDDDDDDDDDDDDECDDDDDDDDDDDEDCDDEEDD
@1KX
TCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACT
+
CCCFFFFFHHGHFIIIJIJJIIJJJJJJJJJJJJJJIJIJJIJJJJGGIJJJIJJIIIJJHGGGIJIIJJIIHHHHHHHFFFFFFDDCDDDDDDDCCDDDD
@1KY
AGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
@@=DDFFFHHHHHJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJJHIIJJIHIIJHIJGGIJJJJHIIHHHHHHFFFFDDEEDDDEFDDDDDDDBDDDDD
@1KZ
GTTGGCACAAAACAAAACGTGACATTTGGTCTCTGGTTTGTGAAGGAGCCATTGCCTCTCTCTCCTCCACGGTCTTAGGGATCCCAAGGAAGAGAAGTG
+
?;;:ADDDHHFDHIHII@FAFDGB@E9CF?CGICDHCCDFD;?D@DEGHGGC@FGEHG7@@FAGGCC>AHCE1;ACDACBC?@=CCCBBB9AABCAC@@
@1L0
GCCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCC
+
<??DAA:<@<+<BE<AEEDD2C?:8?):009?BDD?A>@;8?2;2.;?D7;.6==(38;5>:9=?1;-055&89A>>A:4+4(:AAAAAAA>><>0(+(+4
@1L1
AGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGG
+
@@7DDBDFGGHHDCAEBEGHCDF?FFHCHEHGGGGGIIIIGGDFHEHGGEEDEEHEEFH7?BBCCCB?AB:AC::A>AAACCCCCCC@B9@BB9>ABBCBC
@1L2
TGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCTGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGG
+
CCCFFDDEHHHHHJJJJJJJJJJIJIJJIJJDGIIJIIJJJIIJJJJJIJJJJIJIHHAHHFFFDDDDDCDDD?CDDEDDDCCDDDDDDEDEDDDDBDDDD
@1L3
CTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTC
+
@@@FDD?AACFFAFGIICHHHEHHHEFHEFEHEHECHDC?DD@FB??@?FBDDEFHFBFIGIID==BF@@=FDGHEHHEE>EEHE@;CDDBCACAACCCCF
@1L4
GTAAATGGATTTTTAAAAAAAATTCAGTTTATCAAATTTCATCTTCTCTGCCATTTTAGATTGGCAACTATTGGTTATTTAGAAAATTTAGACTGCTGAA
+
???D=;DBD4A??@EA<EB8C8?D9D>*?DCBD?DDDBD*9?4B@DEDEECD<B@@A=))..7=@7?AC;=77?;?(6>ABA6;A=>>>;;5>5:9,55:
@1L5
GTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTG
+
CCCFFFFFHHHHHJJHIJJJJJJJJJIIJJJJJJIIJFHIIIJIJJJJJJJJJJHFFFEEECEEDDBBBDFEDDDEDCDDEDDDDDDDDDDEDDDDDDDDD
@1L6
GTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTG
+
@=?DDDDDFHFFHFGIIGI@AB@HIII,AA@FCDHE9CFBFHIIIIIGGDFGGGIIIIII@BGHGCA8BFFHGIIIIIIIGIGIHHHECDCCBEAC8>=?A
@1L7
TGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGC
+
@@@DDDFFFBFDDEGEGFGEDDHGIGHIIJDCHGIIIDCHG??B?FGFHIGHGGIEEG@EE>CHAEEB7@DE@DEDEC@CC?B;AA?A:8=@BDA>@CDDC
@1L8
AGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGT
+
@C<DFFFFHHGHGEHIJGGIEHIIIJJGGJJHIJIJIJIJJGGBHHGHHIJJFHHJGFCFHHEHIJICHCH=AECDFFFFFEEECECCDDDDDCDDDDDD8
@1L9
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGAC
+
@@<DDBDD?F>?F>FFG9FEHG<GIEHEIIGGBAHE<D@;FCG;DA:';;;C@HCEEA;;>?>@;@CC@BBBBBC@C>:>534:@BB@-59>@:>:>93:<
@1LA
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@@@DFDEDDDDAFHIGCFE?FDGGGB>FDFHFGIG<?CBDHEEG?6DBDHHBH9F8=8@@@=FA@4CHDCC@:A=?@BDDFEEDCEEEDA>A>32=8?<A4
@1LB
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJGHHJJJJJJJJJJJJJJDFIJGHIJJJJHIHHHHFFDEDEECDDDDDDDDDDDDDDDDDDDDDDDDDDEDDD
@1LC
CGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCT
+
B@CFFFFFHFFGHJJIJJJIEIIHIIJJIJHIGHIIJJJIIJGGHJIJJIJJJJHHJJIJ4=BDDD@BDDCDDDDDDDBDDDCDBBDDDDDEDDCDDDDDD
@1LD
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJ@GIGHJJJJJJJJJJJHHHHHHHFFFFFDDBDDDDDDCDDCDDDDDDDDDCDEEEEDDDDDD
@1LE
CTTCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
?@1ADDDDHHHHHIJJJJJJJJJIIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJHHHHHFF5>?BCDDDD:@DDDDDDDDDDDDDDDDDDDBDDDD
@1LF
CTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTCAATTGTTCAGAA
+
CCCFFFDDHHHHHIHIJHIGHIIJIDHHHHIGIIIHGJIJIJJGHJJJHIIGIIIJJJIJJJJJJHIJJJJGGIJGGHGJIJJHIGHHHHHHFDFFFFF
@1LG
AGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCC
+
@@=DDDDAFAHHBHFDFD:<@GE<EFG@F?1?DDGGHIIDGGEHGIFGCBCFGGHCF=@GGFEHHGGHIHHF@BEB7>A@@?BCCAC?B
@1LH
CTTGCTGGGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTG
+
@@@DDDDDHFBFFG;<EEHE<FDFAFHIGIEFCFGBHGIHG?BG0BBCHGCGEGEHIHEDGG>CHIDHCBEEEDC@?C?>;>A@A?BBB>>A@@C?BB8@9
@1LI
CCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTT
+
@@@DBB===DFBDHEGIGGGGIGADHICHCHIH>G=DDG9BGHHGGEDDGHHBFFBGGGHIBH@CGGGG=CDHHIGH@EHEEB@B@CCC>@@C>@CCCC
@1LJ
GACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTT
+
@@@DDD,AF=ABDF@GG@FEFC?ACEE@++:EFCGIG<CDFF?DF@DAFF9FFEFFIF=CF9=@=CEE6;7AEDDDD7?;;ABCB;>@?BBB(::?BBABE
@1LK
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
@CCDDDFDHHHHFDGAFHIEEFGCAFFHIEII8?DAFGHHIIICFGIIGEHGEHFEEFFDDFDEEEEDDCCDDDDDDDDCDDDDD>C:4@CCCDDDC:>C:
@1LL
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
@@@DDDFFHHHHDGGIIIIJJIIIJAFGHHHIJ:DFFB?DEGHI?CGEFIIEHAHHEHIEECHGFF99?CCCDD=CD@A@@CDDDDDBCCDDC>CCA@CCC
@1LM
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
@@=BDDFDHHHHGJJJHFIHHJIHIGJGGGIIIJIGIIIJJJFJJIHJIGDFHJJFEI;EH:CCHFHDEFBEF>CE>AD>CCDEEDDDDDDDBD:ACCAD
@1LN
GTCCATTCCAGCCTGTGTTCCATTGAGTTCCACAGGCACACCTGCCTGTCCTGAGCACATGTCAAGAGCAAATCTTTGAAGGGATGTGTGGCAAGACCCC
+
CCCFFFFFHHHHHJJJJIIJJIIJIJIJJJJJJEIGEGIJJIIJJIIGHJJIJIJGHJJJIGGIIJIJJJJJJIHHHHHHHFFFFDCECCDDDDDDDCDD
@1LO
CTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGT
+
CCCFFADFHDDHHJIBGHIJIIJGJJJIJJIJGIJJIJ????DGHIJJGGGHIIIIJJJHHHHFFFDFFECEEEDDDEEDDDDDEDDEDDDDDDDBDDDD>
@1LP
CTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGT
+
B@CFDFFFHHHFHIIJIIGIIJJJJJJIJIJGIIIJJJHFBCDDDDDDACCDECDDCDDDDDDDDCDDBDDBDDDCDDDCDDDDC?CCCCDDDDDDDDDDC
@1LQ
GCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGC
+
CCCFFFFFHHHHHJJIJJJJJIIJJJJJJJJJJJJJJIJIJJ?FHIJJHIIJJJJJJIJJEHIDHHEHFFFFFFFEEEDEDCDCDDDDDDDDDDDDDDDDB
@1LR
CCTGTTTCTTGTGTTTTCATAGTCTGTAGTTCTAACTGGTGTATTTTCTGAAGTTCCTTGATCTTTTCCTCTTGAGCAAAAATAAGCTCTTCTTTAAGACT
+
@@<DDDDDFHHHHIIIIIIGGGAEHHFHEHHIIIIIIIGBGHCGFHIGHIGIEIIIGGIIGIAHIIGG=FHIIHHIEIIGGIIHHEHCCDEEEEECCCCCC
@1LS
CCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCAT
+
@CCFFFFFHHHHHJJJJIJIIGJIJJJJGHIIJIIBHGIIIJJGJJIEIGIHHHHGHFFFCDDCDDDDDDDCDDBDDDDDDDDDDDDDDDDDDDDDDDDD
@1LT
GTGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTG
+
@@@FB?DDHDDFFHHIGGEGIIIHBAEFHGE;EFEGHHGGGH@AFGHEHIGECFFBHFCH@DD@EHCEA>AEA@BD;CCEECECCCCCCB<<ABBC(9B9B
@1LU
GGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACG
+
@;?DDDD;ACCFHE;AG?:?CC?@CFHIBGBDF<<??D?FBHGE>G@F>AH>EHECEHHA;?DC@A;;>A@CBCC;:5@:A>?B9>AA:A>:>>CCC>>@
@1LV
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
@@@AAD;D?FF8AF??@E@:?A<C???FF::9?)08@;?*?@<888);FF@7.=@;=@A>C?E=?>?AC@>;6;@;;?,'8&+:A>43(5@?@>4:>::4@
@1LW
GGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGCACCTCCTTCATATTGGCAGTC
+
@@<DDD>:C=CF;:AE@;FE:A<<A?A?3)11:C@??6:0*?99B@DFF>@FI@8FF;D7=@)5-6?=;BDD;;6;(5((,;?3<<9:AB@>:4+>9><39
@1LX
CGGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
@@@DDDDA?FHDHIHGHI>FF@FH9EGGB<?D>FFCDHGHHGEEGHIIIIEBDH@G6<AHA@ECEDDC@CCCCCAC;@;ABCACDDCC>@AACCDDDCCCC
@1LY
CCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAAC
+
CCCFFFFFHHHFHHIIJIJJJJJJJIJIIJJJJJJJJJJJJJJJJGJJJJJJJIJJJJJJIIJJJJJJJJJJJJHHHHHHFFFFFFECDDDDDDDDDDDD
@1LZ
ATTCACGAACCTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTAC
+
@BCFFFFFHHHHHJJJJGIJJIJJIIIJJJJJJJJJJJJJJFGGGGIHGIJJJIIIJGHHHFFFFFFFFCEEEEDDDEDDDEEEEDDDDDDEDEDEDDDD
@1M0
CGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGC
+
@@@DDD>DD>:@C@AGFFF9EHIID<FBFDBFEAEB?DDFIEEE>FFF@F@FE<C@AEEEEF>>@3?>@>AACC:?B@B>>BBBEBB?@<BABDBB<AA@0
@1M1
TCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTG
+
???BD;BD,2DB818<E9B>F?BE1C?8?9**:?AB<BDD94*?9***/9/)=BCCC@;@=A))=C@ACA@<?;>(>A>;>AD>>>5,5>33(+(84(
@1M2
CCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJHIIJIJHHHHHHHFFEFFFFEEEEEEEEEEFEEDDDD
@1M3
CCTCTGCTTCCTTTTTCTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTT
+
@C@FFFEFGFHFHEHIJJIJJIIJCHHGIIJGIIIGGGGIJGEGHDIIDHGHIHG8BBFHGHFGIGIIIJJJHHIICEHCHFFFDEECECBDCDCDDDCCC
@1M4
GTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJJJJJFHIJJJJJJJJJIIJJEHGGHHHHHFFFFFEEDDDDDDEEDFDDDDDDDDDDDDCDDDEDED
@1M5
AGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTG
+
???DDDFAFDHDHIIJJIJJIJJIGGGGGFIGHIIIIEIEGHHGIGGHIFHGEHIGGHIJIIIJIIJEIGFHFFFFFDDDCB
@1M6
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
=@@DFFDFHGHHHJIJJIIJJJJIIFGHIJJJIGGGHIJJIJ?@GIFHIIIJJDHHGHGHFFFFEEEEDDDDDDDDDDDDDCDDDDDDDDDDDEDDDDDCD
@1M7
GTTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
C@CFFFFFHHHHHJJJJJJGIJJJHIIJFGIJJHIJJJJJJJJJJJJJIJJJJJJJJJJJJHHHHHFFFFDEEED@CCDDDDDEDEDDDDDDDDDDDDD
@1M8
ATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAAGTCCTGGCAAGCTGCAATAGTTTCTCTTTCCTAGGGCAGCTGCCGCAACTGTGCCGCCAC
+
1??4ADD,A<DC<++<E<+3+3318?:?DE43**:)88*0*00948*)().-().)...)7)=))7?377);;;7;26(',;;>?'32;>33:>A>&00)&
@1M9
CCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCAATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGAC
+
@?@DDDDDDDDD?CFH@GIGIGGIIGIC8CB<?B>DGHIIIHGGIIIIIIHGF@G@EGGG@CAAAEEEDCDBBCCCCCCCCCBCCCCC3:9AA
@1MA
CCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGC
+
CCCFFFFFHFHHHJJIJJJJJIJJIEIGHIJJJIGIIJJJGIJJJIIJJJJIJIJGHJIIIJIGIJJJHHHFFFFFFFEEDDEDDDDDDDDDDDDDCDDDD
@1MB
GTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACT
+
CCCFFFFFHHHGHIJJJJJJJJJJDHFHIIJJJJJJJJJJJJJJJJJJIJJJJJJFHFHIHGJEIJGIIIHHCHHFDFFD5>@DACDDDDD8ACDDDDDDC
@1MC
CACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGGGCGCAGGCAGGCGGATCTAGGCTTCCTCCATCCTAAGCGCTCGAGGCACTGG
+
??7AD;?D?D?DACE>E:A:+A??3C<1?EC?::*:D869?DD7:@(;'5-49?;:8<</3,7&)5(4+(+4<>AAAA?A<2:(43(&)+)&0&0&+(+3(
@1MD
GACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTT
+
@@@FFDDFGAFFHAFGGGHAFHHGGHGHHG4DGBDD?DBBDF;@AGIGEEHEEHFFFDBCDBD=A??89?<BCC?CDCACC:ACACDDD?B>BB<9<?A@A
@1ME
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@CCFD?DDHGFDFGEHIGJGHJIGDGEFE@GGDFDGDBDHIJGDIICHECEHEFGCHHDFDECC@CEC@CDDCDACCDCDDDCDC>CCCDCCDDCDDDBD@
@1MF
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTG
+
CCCFFFFFHHGHHJJJJIJJJJJJJJJJJJJIJIGHIIJGII@DHIIJJJJJJHJJJJJJIJIIGEIIJIIIJJIHHHEFFHHBDEE
@1MG
CTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCA
+
CCCFFFFFHHHHHJIJJJJJJHGHIGJJIJJJJJJJJIIGIIJJJJJIIIIJJJJJJJIJIJFEH=BDFDEDEDEDEDDBDD=?ACDDD<<BCD:@CDDD
@1MH
TTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGT
+
@CCFFFFDFHHHHJJIJIHIIJJJIJIIIFGIJGHJJJIJIJJJJJJJJJJJJJJJJJJJHIIIGHJJJIIJJJIIHHEFHGHFFFFFFECEDDEDDCDEE
@1MI
CTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTG
+
@?@D?D?DHDA?DCB3?FHEECA:AHE?A?AFH@@CDH>E9CGIBBD@;F9BDB?9?9*?F*9*?D8D<BF8F==FH3@==DHHHG@;@C??CAE?C>DDE
@1MJ
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CC@FDDDDFHFFHIECEFHIDCEHEDFHHIIIJJIJJIJIJJFIIIIJI@GIGCHEHIGJHHEECF@CDFFFECCEEECCDCACCDDDDDDDDBCDDD9@@
@1MK
GGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGC
+
@CCFFFFFHHHHHIIJJIIJJJJCGIIIGIIJDGGGIGIICHIIFGIIJJJJJJGIIIIJIICGHIIIEHFEFHE;BDDDDDDD?@?BDDDCCDDDDD
@1ML
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@B?DDFFFHHHGGJIIJCFHGHJJJJJJJJIJJJJJIIIJJJIJIIJJJGCHHJIJJFIJHHIJJJJJHHHFDDDBBDDDD@C@CC@@CDEDCCD:CCD
@1MM
GGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTC
+
@@@DFFFFDHHDBGBGEFHIIIIIIIFBFEHHHICHGGDGHBHEGGGGIIBH9BCEHDC>FFHHHGGIIGIHHGIE@CEFGHFCDCC@DDAC=CDCCCCDD
@1MN
GCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGT
+
@?@FFFDDHFHHDCCFGIIJJIGHHGD8GIIIEEAGHICFGH>CEGHDHFFCDFCCCDEECCCD>AC>CCD;?BCDDDCCDDDBDDCCCCDB<@8?B2<?B
@1MO
CTAAACTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGAC
+
@BCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFEEEEEEED
@1MP
CACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTT
+
CCCFFDFDBBDDFGGGIEHGBHHCHHIFF?FHIIGICGHIIIIIGIIIIICHIIIIGEHIHHGEHEEFFFECEDECEDDCD>@CACCDCDDDACDDEDDDC
@1MQ
TGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHHHJIJJJJEIHGIJJJJGJJIJIJJJJJJJJJIIJJJJJJJJJJJJGHIIGHHFEDFFDFEDEEEDD;?B9@CDEEDDCDDDDDDACDD
@1MR
CCTTAAAGCATTCTCCATTTCTCCCTTATGCCGCGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCT
+
@@@ADDD;FFBB8GFIEGFE<<,C<EH>@+<2@)1@AG?B4<BFB?4BF@8=FFF4@7)8CEE7)=7?EE)7B?BDDBDD;;A@;;;>;>@DABB@35(:A
@1MS
GTCCAGCCGGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCACCCGGATGGAAAAGCCTGTGTACAGGGCTCCGC
+
?@@D?:ADHHHFH?CE<9?CB?GDC:?F???GDHIB@F';@A;-=A7-(.;?6?C/88/<B?C?B4>(44(05&0<<C@C?988>8A@44>>:9888<85>
@1MT
GGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTG
+
@@@FFFFFHHHHGJJJJFHIJIIJJJJJGGIJIJJJIFIJJJJHHHIJJJIJJIJBDDDDCCC@C@CD>BCDDDDDB:@CBBDDDBBACDDEDDCDDDDDC
@1MU
CTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCT
+
@C@FDFBDHDFGHJJJJIGGHJIJIIJIJJJJIIJJJJJGIJGHHIIIIIIIJJJJIIIIIIJIJJIGEHJEHHHHHHFFFFFDDDDEDDDDDCDCCDDDC
@1MV
CTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGG
+
?@@DD?DDCACBFEFIFB:ECH4CCDHFEF>GFFEEEEE9D?9DGIIFFIIIII)@FBDCFEA>DEIFEE.?;7.?@ADB(;????AAA>?5>5:;@:ABB
@1MW
ATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGC
+
BCCFFFFFHGHDHIGIGJJJBGHGGHGGIIIIIJJGIJJJIJJIIIGGGIIIJIJIIIEHIIJJJIJJHGG;@EEGGHFHHGHHBFFFEEEEEEEDDDDDC
@1MX
TTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGAC
+
@CCFDEFDHHHHGGHIJJJIIJJJJJJIJJJJJJJHHGHFDDEDEEDDDDDDDDDDDDEDDDDDCDDDDDDDDDDDBDDDDDDDDDDDDDDDBDDDDDDED
@1MY
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
@@@DDDFFFHDDDGGGJIJIGGHGG3CEF9EGIDGHGIGHGGHI?BCGGFFHIGIDGJJHFEEADD5==C@ECBCD@-:CCCC?BB@<<ACDDCCDACDCC
@1MZ
GCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCT
+
@@BDFFFFHGHHHJJHIJJIIJIJJJJHJJIJIHHJFHIIIIJJJJJJJJJJJJJJJAGIHFFFHHEBEEEDACCEEEEDDDDDCA?ACCDDDDDDDDDCD
@1N0
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTT
+
@@@DDD;B?FDD?BAEG>F:ACDGC@AFBE><EB*9??;CBDF@FEDC?BF?FFB8=8BFIII@88B9@A:>6-;A?B?86<?2?@(4<@A>AABBBBBBB
@1N1
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
C@CFFFFFHHHGHIJJIGGFHHJJJJJJIIIDFGGGIJGGIIIGIIIJJJJJJJJIJIIIHGGHHBHHFFFFFFFED;ACD@CDD8?<BCCCDDDDBBC
@1N2
GCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATG
+
@CCFFFFFHHHDCGGHIJJJJIJJJJIHIJJJJJJJHIJJIJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJIJEHHHFFFFEEECCDDDCDAAC@CCDACC
@1N3
GTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGC
+
C@CFFFFFHHHHGJJJGHIIJJHHJIIJJJJJGIIJJJJDGIIHIDHHJIJJJJIJJJJJIJJJ@GHHHHHEHH@DBDDFFEE>C@BDCACDDDEDDDDDB
@1N4
CCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJHGJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJHHHHFFFFFFEEEEEDDDDDDD
@1N5
AGAAGCAGGAGCTGTCGGGAAGATCAGAAGCCAGTCATGGATGACCAGCGCGACCTTATCTCCAACAATGAGCAACTGCCCATGCTGGGCCGGCGCCCTGG
+
CCCFFFFFHHGGGJEHHJJJJJJIJIIJJIJJJIIJIJIIIJIIIJJIJJIJHFFDEEEECDDDDDDDDCDCCDDDDDDDDDDDDDDDBDDD@@BDDDBDD
@1N6
CTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATT
+
@@?DDDDDH>FFDHEEEHBHAAEHEEHE:EAA9B@GG:C<::D9C???@GB4BFFFGGEAFFII95;??CEHAHEE>;@CD>@C>6;@ACC=;>A>>:>>>
@1N7
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
@CBFFFFFHHHHGJJJJJJJJJJJIJHIIJJJJJJJJJJJJJJIIIJJJJJJJJJJJJGIJJJJIIHHHHHFFFFFEEEEEEDDD=BDDBCDDEDD:@BD
@1N8
CTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGT
+
@@@DFFD?DADDHG@E7@9FHCBHG9<EHEE9B<BDDFDDH<BBBFHGGEHIGCHICGFGDAF@GIIGB<A>BDFB?CACACBBBB?@>C;;A>:@A@:<+
@1N9
TGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJIJJIJJIHHHHHFFFFFFFEDEEEEEDDDDDCDEEFEDDDDDDDDEE
@1NA
CTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCA
+
<@@DB;DAFFFFFIIDEIIIE@HGIGDGHGGHHIIFGIIIIIGIIIIIIIIIIIIIIIIIIIGBE=FHG@F;;EHC=DHE?C=7A;;CDDFF@AACCC@@
@1NB
TGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGG
+
@@@DDDDDBBDAH3CFGGCFH@E;:?CDGHIE<FAGIGGI<1?@AB<CGG55@AEEEE@C666@ACC@CACCCCCC<?BBB?9??:>>?CCB@?ACBCCDC
@1NC
TCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATT
+
<@@==:DDHHAD@EHGIIIGBAFHBFEHHGGCFGGIIGGGADDGGIIIEIGDHHHIIIIGIGIIFFEE@CCCCCC=ABB595>AA>:@CCCCCBB098ADC
@1ND
CCATAAACACCCATGCTACTGGGGTGGTCCTGACGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@@@ABDBDHD?FA??@E@HHIGII)?8?BDBD*:8?@DBDFIDHEB;8@F@EHEAH?;?;@@>;.;AAC>@?;5>@@>@;C::@CCC99?CC09+28+::
@1NE
GGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTC
+
?;?DDDDD>D<A:<A<AE3<F;<3<CE>E@E>E?8?@@@7?AAEIIICI>@A;CA=<?D@>?@?;5985>A95,>:B:+::AAA<<?>0555;8><:>AA:
@1NF
CGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTG
+
@@;DBD>D<:<C8?2<CBBCE<ACCHFFFFEFEBDGDGEFFDDFFEEEFIII@D?0?FFFAFFDFGE.7@@DEF(?AACFF;B;?;@?A6;>@BBABB@;
@1NG
TCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCT
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJGHGIIJJJJJIJIIJJJJJJJIJJIJJJJJJJJJIJJJJJJIJJJJIIJJIGHHHGFEFFEEEEEEEEDDD
@1NH
GTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGG
+
C@CFFFFFHHHHGIJJJJIJJIJIJJJJJJJGGGJJJJJJIJJIIIIIJIIIJGIIIJJJJIJIJGEHGHFFFFDDEDCCCCDDDDDDDDDDCDCDDCDDD
@1NI
CTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTT
+
@@@<=:=B<A:CFB+<CGIGIB<CGEGC<AAFHIIDAD?8<FHGBB6@6=8288=@D@@@;=>>BBC)7;CC@CCCACCD>CCCACCA>@ACCC;@CC@CC
@1NJ
TTCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJIJJJIJJJIJJJJJJJJJJHHHHFFDDDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@1NK
CAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTTCCACATCACCACGCCACGTTCCCTTCTAGACTGTTCCAAATGATCC
+
??;D7;DDC4A,A<EFB:CE?E+A4<FF9C<?3C9*:9*:*?*0:*:::***9?F4?8**=BF(5@('5'6(=3;?:)7)66@(((-;;;@(5(5;(5
@1NL
CTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
@@@D7DBDFFFFHGHGIE@HEGH:?F@G<FHEHIGHHGGG<BA@6?F6=.);F=CGEEGCEEHCEDEDEACDCCA>5;>=9<AACCCCCCCCCAACBC:
@1NM
CTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTT
+
???DDDDDHHH>?<A:CGIHGHIHIGGIEEGICCGEC=GIIIGGEHFABDDEEDCCCCBBBBB@CC@CCCCC@CACCCCCCCCCCCCCCCC@CCECDDACC
@1NN
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHHHDHIIJJJJFHJJIJJJIIJJJJJJJII>HIJJGIHIEEHIJHHEEFFFDDDDDDDDDDDDABDDDCCDDDDCDDDDDDDDDDDDDDDDD
@1NO
TTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTC
+
CCCFFFFFHHHHHGIJJJJJJJJJIJHIJJJJJJJJJJFHIJJJIIJJJJJJJJJJJJJJJJHHHHFFFFFFEEDDDDDDDDDCDDDDDDDDDACADDEEE
@1NP
GGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCC
+
@@@DDDFFHDFDAFEFHGGHGHHHIIIGGCHG?CHHD<???FH?DHIIHCGIHIGGHIGADEHFFFHHHFFDFEECCCACEEA;@BDBDDD??ABBDDCCB
@1NQ
TGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTG
+
CCCFFFFDFFHGHJJJJJJJJJJJIIGIHHIJGIJGIIIIJGHGIGGIIIIJJIIJJFIIIIJGIGIHFHHFFFFCDD>@B;@D8?CCDDDEDDDD@AD:?
@1NR
GTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAAC
+
CCCFFFFFDHHHHIJJJJJJJJJJJJIIJJJIJJJIJIIIJJJJJJJJJJJJJIIJJJJJJJJGGIJJIFHHDFFEEEEDDDDCCCBDEDDDDCDCD@CCD
@1NS
GGAAATTCCATTCTGTTCCACATCAGCTTATGCATTGGAAATTTTGTATCTTTAAAAAAAGATTTGAGGAACAGAACTGTGTTTTGATGTTAACAAATTGT
+
::=?B=ABHHHFHB<FH>CIGEDHGDHDB?CDH<?<F<9EA@CFE?:4?<@A@FGHGAAAAFCFHEAD@AEEEAEB@B?@CCCCC;15>@@>CCCCBCCA5
@1NT
GACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCT
+
@C<DFFFFGGHHDHIIIIIHIGGIBHE9EEHHEGI?DDBEGIGIIIIGEHIIGIIIIIIIGEHIGGIGGGHHGAEFFDFFFCBBBCCCCB>CC>BCBBCBC
@1NU
TGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGG
+
CCCFFFFFH<FHHJJJJJJJHIIIIJIIJJJJJJJIJJJJGHIJJHIJJJIIHHJJJJJJJJIIJJJIIJJJJHHGHEHHFFFFFFDCEEEEEDDDDEEDD
@1NV
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@@@BDDDFHFGHFGIHBEEHGHHIIGIIIGH>AHGGIIFGE?BDGEHIIIHIHIGFFGHIGIIGIIIIIIIGGFEHHCDDFCCBACCDCECCBBCCC>@CC
@1NW
GGAAGGGTAAGGGCATTAATTTGCTGTCTTATAATCTCATGGTTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAGTTGCTTATCTTTAGCCTCCAATT
+
??8?DA:B3C+A+2<:<C<??<<?CEC@+<C**1@?@:1:**1?4*BD*?BD@3)?4**/9BB=B))/=)8).8@=7).==)7)=))).7733)..;@9;>
@1NX
CTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCT
+
CCCFFFFFHHHHFIJJJJJJJJJJJJJJJJJJJJJJJJ?FHJJJJJJJJJJJJJJJJJJHHHFDFFEDEEDDDDDDDDDDACDDEDDDCDDBDDDDEDEDD
@1NY
CTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJHIIJIJJJJIJIJHIJJJJIJHIJJJJGIIJJJJJHHHHHHHFFFFFDDBDDDDDDDDDDDDDDDDDDDDDDDD
@1NZ
CAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGG
+
@@;BDDDAFF?AFF111EA?E?F?B>B:?FD3?DDD???9BD?((?88=)8@=CD5@C;AF;?'33,15=3>(:3>AA55AA@(+4@+38&+<<<1:>A(
@1O0
GTCCTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATT
+
@@@FBDFFDBFHHCGIIIEIIICGHGHDGDGHIIIGEFEHII?FHDDEHIHIIIGCCFBHGHHGIHHA559?=CEDDDCCDD;223=A:>?<+58ACDDED
@1O1
CCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGT
+
CCCFFFFFHHHHGJJJIJJJJJIIJJJJJJJJJJJJJJJIIIJJJJJJJJJHIJHHFFDEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD5
@1O2
CTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIIJJGIJJJJJJJJJJJJJJGIIIJJJHHHFFFFFEEEEDDDDDDDDDDDDDDDDEDDDDDDDDDDDDDDDD
@1O3
CACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTA
+
@@@DFDFFB>HHGEEGBFEIEBHAHGIIIIEEGHIIFEGDFFAC@BG9?DHBFD>FHIHBHIIIBHIHCCHEHFFFDFFECCCD;@;ACDCDC?D?BBCD
@1O4
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@@@DBDDDDBFBAF>FFE,AEHCGG2CFHGH9990?0?DFACBCH@F;=@EHEE>>377;;BDAC;AAA>C35;@ADCCCCC::AA::@BC@A4:3+:<98
@1O5
CCCCCTCTTTCTATAGTAATCATTTTTATAGATGTCTCGGGCGAGTCCAAAGTCTCCAATCTTCACTATCCGTGGACTGGTA
+
::+=AD@?CDC4A<4E22:,,<<E4,3<C2AE+AEE>4*@?@0(.-=B=4)))8==3)).)=AA;;??DD9;(;>=3(((-,
@1O6
GCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGGGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
@@@BBBDD;F4A2::AAE:F15@B?A@BBB>A@38@BABA32AAAB&0&5908>::333+339+:@:AA@>:ABB9@0(:@B@B>>>+:?@BB+:9>@:<
@1O7
GTCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGC
+
CCCFFFFFHFFHHIJIJJJJJJJHHJJIJJJJJJJJJJJJJIJIIFHIIJJJHJFGGIIJJJJJJJJJJ=DEHHHFF=CCDCDDDDDD<ACDDCDDDDDDB
@1O8
GTCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCA
+
CCCFFFFDHFHHHJJJJJJFHIJ@FHIJIJIJJIJJJJDDDDDBDDDDD9BDDDD5<BDEEDEDDDDD5@BDDD9@D<CDDDCCDEC@CCEDDDDDBDDD
@1O9
GGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGG
+
?@=BDDFDFFFFFEFGHGIIIGIFGIIIJGHIGDHGHIIIIGGGHGEHHIBDGHIIIIIIICFHIGGHIJEEGIIIIGIGHIJHHHHHFHFFFFFFFCCCC
@1OA
AGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTG
+
@@@DDDFFGDFFHIBGGIGHGGCGAED>GEE9@DHEGEHDDCEEGFDC?DFHIJJEGGIIC@EFCGGGI7@ACEE>C1??CCB?><&08@CCCBDDCB?>A
@1OB
GCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTC
+
CCCDFDDDFDFHDFEBCFDIHEHHDACHGIIIEIICDHGGIHDDEFIIIIGIFGFHBC@FHG;)=@EHHHGCCC=?C?@@ACCCCCECAAACDCCDDDC;A
@1OC
TACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTC
+
@CCFFFFFHDFHHIJGHGGFHIFHGHHHIJIJJJIGHEEAEEEB9<BCCEEDDCCCED@@ACDC>CACD9ABD9?BD9BD(<><>CDCBBCDDB@DDD@<
@1OD
CTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTG
+
@@<DDA?BDFDFD@F@ACDHF:?;;C@H@AFE1CFFEI@9<BC9BDFBBGGG>?DGH<D?88FH;C@CG@FHI@@E=@@)=C>=)7?D?B>C>A>.;;;>(
@1OE
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
BBCFFFFFHHHHHJJJFHIJHJJICHHJIJJIJJJDHHIJIJJJJJJJJJJJJJJJIHHHHFHHFFFF;AEEEEEDDDDDDDDDDFDEEEDDDDDDDDDE
@1OF
GTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTT
+
?=?B?:=AADBFBHBEGGGGB>3AEEC@DBCEHEIE@FGGGGAGC@;@HEHIHEE@CDBCC3>?>ACCBC:@@>ACCACCC::4@>:>??BBCBBB><::@
@1OG
CAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGT
+
C@CFFFFFHHHHHJJJJJJIJJJJIIIIIIIIJJIJJJJJJJJJJIIHJJJIJEIIJIGGEHHIIJJJJIJJJJJIGIJIHHHHFFFFFEEDDDDDDDEED
@1OH
TTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTT
+
??@DDDBBFDDHDAAEFGH<CDHCHIII>?B?AAAGG?F?FEFCDGG<BGEHIBGHG>FC@FHGGAHGE=B8;CH4=CE=DCE@EE:=A7??);@;B776;
@1OI
CATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGAT
+
@C@DDFFD@FHBFB@GGEEHGA?EHBHIEBAGGHIG?DHG<FG7=BFFHF@ADAD?EEFDC3>BCC5>@CB=8<B>@CCCCDCACCECCBCC9A>CCDC@@
@1OJ
GTGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
CCCFFFFFHHFHHJHHJHHJJJIJJJHHGJJJJJJJJIJJJIJJJIHHGHJJIJIJJJJHHFFFFFDECCEEDDDDDDDDCDDDACDDDDDD9ACEEDDD
@1OK
GTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGG
+
CCCFFFFFFFHHHJJJIIJJJJIJIJHIIIIGGGGIJJGJJIJIJIJIJJJJIJDGGCFEDHHHIIJIJ@EDGHJGFEHHFFDFD9?@BDDDDDDDDDDDD
@1OL
GGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTG
+
@@@BBDDDDHA8<AFBF<D@DGHC;EF2<AEHGEFH9FCF@?@:FD:;4=78@;=7==EEAD?=?A@A>=?>?;@ACCCCCCC>??ACCA:CC:AC::44>
@1OM
GGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJHJJJJJJJJHHEEHFFFFFFEEDEEDDDDEDDDDDDDEDED
@1ON
GTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTT
+
<?@FDFFFHFDHHIHJ9CFE@IIHGHIIIIIJJHIIIG@HIJJJJIIJJIFHHIIIGGIHIJJJJIFHGGIBHIJIIIIEEHIHFHHHHHEFFFFFDEEDE
@1OO
GCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCT
+
@@<BADDDDHH8CFHA?B65<AC8383>8+8@BD>C8?(3?8885B82(++99>>>3>A:>:@3@ACCCB9>B&3:>8393>C>C3+>4>>>C:>934>A3
@1OP
TGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGC
+
B@BFFFFFHHHHHJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJIIJJJJJJJJJJJJJJJJJJJJIJJGIJJJIGGHHHHHHFFFFFFEEEED
@1OQ
CGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTG
+
CCCFFFFFHHHHHIJJJJJJIIIJIFHJJJJJFGIIIGIHHJIJJJJBDHGHIIJGIHIJIJJJJJJJII=CEFGF;BB@CEEEEEDCDDDDDDD>A@CDD
@1OR
CGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTC
+
???1AAD?F2<AB<CACEFGIBH?3AFFF>CFE@BEDDF)??BGF?DFFDFEFIBEFIBEEEADDC@:;>A==@@A>@<A@B@B<2<834?AB-597>9:@
@1OS
TGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCC
+
;:?DDDDDCD<DCDAFGE@CCBHCHIIIFEEHEB>DHACEH<GCHHEBBBEHFFGHG;D<BHIIGIGHGGE@AFG@GIBCC=AHDDDD?@CA:@C@CCC@
@1OT
CTTCTCTTCTAAGAGTTTAACCTGCCGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATC
+
@@@DDDBDDABBF>?GEBGHGEF>FFGE<FDF@C>DGG>FHGI099B4BDDBGI@GEGCGIIEA@;C@>HACHEC;?>BCDD>?>>CDCCC@CAC@>@;
@1OU
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIIJJJJJ:BC>CEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@1OV
GCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTG
+
CCCFFFFFFHHHGJJJFHIIJIJIJJIJJJJJJJI?FHIJIIIJIJJIGIFGHHIIJJJJJJJJJIJIIJJJHGGHHHFFFFFDCECEDDDDDDEDEDDDD
@1OW
GTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCC
+
@??DFFFFHHDHGEGIIIIIEHEBFHHFFGIGHGIGGIIHHGHGDHIIIIIIIIIGBHGGII>EHGFD@CDCCEEEDCCC<>AC@CCDDDDDCDDDCC?BB
@1OX
GCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCT
+
;@@FDBDBBDBA?GGGHFEGEHHEI?GAGHGGGAD;?DH;F00@A@==@==;;??5C@@D;>ACE@@BB8@C>>:@3(:5:>><<@<>:ACC?<:@0:>CC
@1OY
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGCATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCAT
+
@@@;DBDB;;+:?A@E<A3AACFF@FE<C8C>3?C@<34*?BFB@6(?-'5=)8=@47=:'=ACCDEDC<=83@>@@@5:5?9:?@>ACC9>4(+(44>A>
@1OZ
CTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIIJJJJJHFADDDDDDDDDDEDDDDDCCCDDDDDABDD
@1P0
CCTGGCTCCTTCCTGATAATGTTTAGTTTGTAGTAGTGGCGCAGGGCTCTGGACATTTTCTCATAGGTCATGTTTGTTCTGTTCTTATGGTTTCCCCAC
+
CCCFFFFFHHHHHJJHJJJJIIJJJJHIJJHJJJJJIHIIJJJJJJJJJJJJHIJJJJJGJJGIHIJEHHHHHFFFFFDEEEEEEECDDDACDDDDDDD
@1P1
TTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATAT
+
1??7DDD>FFBFHDFEDFEHHECHHEHGH<?9AHHF*C:3CFAFCEHCDB0??9BFGII>B@DBF?;8=<BDCG@FDGGAE=CEHCEBC>>>>;66;>AD
@1P2
CTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTT
+
CCCFFFFFGHHHHEGIIJIJJIIIJJIIIJJIJJIIIJIIJJGIIIIIGIJJIJJJJJJIJJDIGGHFFFFEEE>CCDCDDDEDEDEDDDDDDDDDCDDDD
@1P3
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@CCFFFDDHHHHGJIJJHHHIJJJJJIJJJJJJJJIIJIIEGIJIIJICIGIIJJHIIHGEHHFFF,;B@CDDCCDDDDDDCCCDDDDCDDDDDDDDD@BD
@1P4
TGTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTGCTCT
+
@@=BD?3?;CF?F>F>:CEIDFG@DH>B=FEHEGG@FGGBEGICH?B99?9BDFGG:FDCDHGHADE:@47;?>ACCDC;;@@CCC@;;>;?BB?8<@A>C
@1P5
CCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAG
+
@@@DDDDDDHB;:CCF<FBHCF3AEBEDFCBGAEG?C?DCGGEEEEDGDG<?BD?9DDFABH:BC;@F
@1P6
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJFHJJJJJJJJJIJJIJJIHHHHFFFDDEEDDDDDD@CDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@1P7
GATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATA
+
@@@DDDDBFDHHFEBG>DEAB9CFGEEGGIIIIBFHHGIEDGGBFDFGCGGBGGI5==DH?EEEADEEEACCCCBBB8=?@:ACBCC@>@CCCCBBB?BC
@1P8
CTGGCAGCCTTCCTGATACTCAGTTACACACTTCTCAACTTGGAAGCTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCT
+
@@@DAD?DDHDHHEGIGEHGDHEACFHIJIJFEGGGJIIJJHEGEHGGGIJJJIECIDGGCGHIGHJHC8@GIIJIHCHEFFEEDADEEDDDCCCCDDDCC
@1P9
CTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
@+?DDDDBDA;CD2ADEHGECCEFHF@EF<FDEDHHHCGDCF<DGGGGE>GGDF>FGGICGHGGE=CEECH@D@DA;AC@?CCC;>@<>CC?=B?B?CC@4
@1PA
TCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTC
+
??@DFDFDHGFHHIIAFHHGGEHHEEHIGIGGIGHC?EHIIIGGGCCHGEHHG@DGHIGIIGBGGHGGIIIGGCHIGCE>CCHA@;@DDFFEEECCCDE;;
@1PB
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGGTCCAT
+
@@@DDFFDBFFAFGGBB@ECBEHGIEGGBAGFE<B>9898*1?=C8BBDGHI4=CDC=;?CEFD>@DFE<A>C@;A@>(;;;?@<;(:>5>A::(998>3
@1PC
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGGGCCATATGCAGACTGAGCTGCATAGG
+
=?=ADDAA4ADADE?<@13)2AF<<C?1:?@<1?9DDB)?B<DDDADBADB==C:77@AA@DCDDDA@.46(.6(5;?<9:>(5>5,95>:>A>3>A>AAA
@1PD
GGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGG
+
CCCFFFFFHHHGHJJJIJJJJJIIJIHHIJJJJJFGIJJHJJJJJIIGHIIJGJHIHFFFCEEEDEDDDDDDDDDDDDDD@CDABDDBDDDDD>DDDDEDD
@1PE
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCAT
+
B@BFFFFEHHHGHGHJIJIJIJIHJIIIIIIIGHHIIHEGIDIIIIJJIIIIIIJIGIIJI@GHGGGHHH=BBDDCBBCCDDDDDDDDDDD:?BBDCCDD
@1PF
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
CCCFFDDFHFHGHJJJJIIJJJIIGIIJJFHIJJGHIIBFHHJIGIIIJIJJIJJJJIJJJHGHHHFFFFDECEEEDCDDDDDDD:>CCDDDDDDDCC@@C
@1PG
CTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTC
+
@@@FDDDFHFHHHIJJJJJJJJJIHEFHIEHHJJGGIJCHIGIIGIJGGHIHJEHF>BEEECECEDDCCC@ADBBDCDDBCBBBDDDBDDBDCCDBDDDDD
@1PH
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCC
+
CCCFFFFFHHHHHJJJJJJIJJHIIGJJJIIJJJGGHIGHGIGHDGIJIJJIJJJJIGIIGGGGIIGHGHHFFFFDDDEDDCDCCCEDDDDEDFDEDDDD
@1PI
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@@DD1BD<FF4<:?A<E<:CE:@?F;9:19991?<DDBD;D9B99B?9?DFFFIC>B;CFFIEA6C777.7;7;7;;7=@8>?=B849:4((+42??2<B
@1PJ
TGCCATCCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCT
+
CCCFFFFFHGHHHJJIIGHIJJIJJICCGGHIHHBGGHIIJIJIJJCGIGGGHJJIIHGHEHFHAEHFDEFD>ADCDFEDDDDADBBDD<CDDCCDDDDDD
@1PK
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGT
+
=?@D?DDDFCFB;CFGDDGHBFHHHGHGG:?8?*:DHGCG8)?<FG8BFCHIAHGI7CCHGI5:?>@?CE3;A(;ACAC@B8?:ACCCC:@C:ADCCC>3(
@1PL
AAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCC
+
@CCFDFFFHHHHHGIIJJIJJJJJJFHIJJJJJJJJGIJJIIJJJIJJJJJJJJJIJIJJJJJJJJJJJJJJIJHHHHHFFFFFD>ADBDDDCDDEEDDDE
@1PM
CTCTACAGCAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCAC
+
?7@B:B;:+=:2CCAEG@?C?C?:CHAHHC9C<?@CC):8@;3:BDDDG9BDD<FFFFIE>C@FF>FFF>7((=D;?CEEE>37(7@@@A
@1PN
GCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTC
+
@@@DDDDDF?AFHADGH<AFGGCBF>GHIIIIIDGGADFHIIIBFIIGIIIIIDFCB?B@C@B>ACCCDCCCB<@BB>BCCCCCBB@BBBAC:>@CACCCC
@1PO
TCCATAAGAAGTTACATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTT
+
CCCFFFFFHFHHHJIIJJJJJGHGHIIEIJDHGIIBFHIGIHIIFHIIJGGIEIGI@GGEHFFHGDDDECE@CEDCCDDDDDEDDCCCCCEECDCCCCCCC
@1PP
CTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHGHHHJJJJJJIJJJJJJJJJJJJIJIJJIJJJJIJJIJJFHIJJH@BDEDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDEDDDDDCC
@1PQ
CTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCAT
+
BB@FDDFFHHHHHJJJGFHGIHIGHIGIIJGGIIIJJFGJGIIDFGDHGIJJGHIIGIJJIJGHJHEEFFFECEE>CCDCAACDDDBDCCBDDBCDCBDDD
@1PR
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAG
+
CC@FFFFFHHHHHIJJJJJJJJIIIJIJJHIIJJJJJJIHIIJJJJ?DHIGIIIJIJCHFHHHFFDEDEEDDDDDDDDDDDDDDDCDDDDDDDDD
@1PS
CTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGG
+
@@@DDAB2+=CADFFIIIEGFGCGGGFGIFI@FFFF@AFEEEI>EE?9@@<@8@52::(339@@>ABBBBB5@BBB>>BBB>@&0&0<(4<-9B058?@
@1PT
TCCAGTTCCAGTGACTCTTTCGGTGGAGCGTCAGTGGGCTTTTGCTCCAAGGAGTGCCTGCTCATTTCAAACAGGAGCCAATGGTGCATCCAGCTCTCAA
+
@@@DDDDFHHFHGGIIJJIIIIIFHGIIIIJJIFFHIJJJJJIIIEHIFEEHDE@DEHGEIEAA?EEHHFFEBEDEDDBCDCCCC@CADCDDACCCDDC@
@1PU
GCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFEFHHGHHJJJJJJJJJJJJJJIJIJJJJIJJIJJJJGIIJJJJJJJJBHHIIIIIJIJJJJGHHHHHHHHFFFFFFDEEDEEDDDDDDDDACC
@1PV
GTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAAC
+
@@@FDFDBFFFHHGGHGGGHGFEEBHHIGEDAFGDHGCFHHBFFGIGIIEGGIJIAEHCHBAADDDDDBDDCCC>CC:>:?BBB?<@BDDDC@CDCD@>A9
@1PW
TTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTC
+
CCCFFFFFHHHHHJJJJIJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJIJJIJJJJJJJJJJIJJJJJJJHHHHHFFFDDDEEDDDEEFDDE
@1PX
GTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATC
+
@@CFDDDDFHFFDGGHJJJJIGIJGHIIJIGIGIJIG@FE<FGAFEGE;EHIIJAEEHFHFDFDFFFCADB@DDDDDDDDDDBBDDDCDDABCDDB@CDDC
@1PY
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
@@CFBDFFFHHHHIJEHIJJJJJJIJJIIJJJIIIJJIJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFFFEEEEEDCBDBDBBDDDDDDDDCCDDEDDDD
@1PZ
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
CCCFFEFFHHHHHJIIJJJJJJJJJJJIJJJJJJJJJJJJJIJJIJJJJJJJJJJJIJHHHHHFFFFFCEDEEDCCDCDDDDDDDDDDDCCDEEDDDDDDD
@1Q0
TCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGAC
+
CCCFFFFFHHHHHJJIJHIIJJJJJIJJJJIJJJJIJJIJJJHHHHFFFFFFFEEDDDDBDDEDDDDDDDDDDDDBDDDDDDDDDDDDDDDDDDDDDDDDD
@1Q1
GCTGAGGCAGGAGAATTGCTTGAACCCTGGAGGCGGAGGTTGCAGTGAGCCGAGATCACGGCACTGCACTCCAGCCTGGCGACAGAGCGAGAATCCATCTG
+
CCCFFFFFHHHHHIIJJJJJJIJJJJJJJJJJJJJJJJJHHHHHHEFFFFEDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDD
@1Q2
CTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACT
+
CCCFFDEFHGHHHJJJJJJJJIIJJGHIJJJJJJJJJIJIJHHIII;FHIIJHIJJJHHHHHHFFFDECBDDDDDDDDDDDDDDCDBDDCBACDDEEDDCD
@1Q3
CATGTATTCAAAGACCATGATGAGGGGGTCCCCATCGCCGCACACTCCATAGAACTTGACAATGTGCTCATGCTGCAGGTTGGTGAGCAGCTCGGCCTCCC
+
@<?DDDD?BFFF4<CFBBHFCCF<3@)::@DGF>DFCFB@FEEEA77?>@>)7;A@;@ABBAA;>@55>@>:@@>>5:<<A<>B(:?3:383405?<@@BB
@1Q4
TTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGA
+
?@@DBB?DHFF<<EFIGGHDAEFBHAGHHGHIIGIIIIG:CDEGB=FEGHIII?BFFHGGICHGHGHGIIEHHGDE;AEEEEFFFFDC>CCCCA;;@CCC
@1Q5
CCTATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCG
+
CCCFFFFFHHHHHIAFHHIJIJIJJIJJJJJJJGHCGIJJJJJIJJI@BEHHFFFFFFEEDEEEDDDDDDDDBBDDDCCCCDDDCDEEDCDDDDEEEEEDD
@1Q6
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGT
+
CCCFFFFDHHHHHJJJJJJIIJJIJJJJJJJIJJIJJJJJIJJJJJJJIIIJFGIJJJHHHHFFEFFFEEEDEDDDDDDDDDDDDCCCDEDDDDDDDDDDA
@1Q7
GCTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCC
+
@@?DDDDD:DDDFG8?CGBCF>FHIIFIIIIIIGG9FG7@@GHIHGGICEH?A?BC>DBCCCC@?;?CCC>@<C?(>CC@>@BBBBBBBBBCCCBBBBBBB
@1Q8
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
CCCFFFFFHHFHFJCFHIIG@GGIGGGGBFHJJJJHHHBDBCDC>CDCDDDDCCDDDDDEDDDDDDDCDDDDACCDDBBDDCCDDDDDDDDDBBCDDCDD
@1Q9
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCG
+
CCCFFFFFHHHHHJCFHIHIIIJJJJIJJJJJIJJIJIIIJJJJJJJBEHHHFFDFFDCEEEEEDDDDDDBDBDDDDCDDDDDDDDEEDCCDDDEEEEEDD
@1QA
GATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCC
+
CCCFFFFFHHGHFIGCFHHHJJHJJJJEIIJIIGBGHGIJJJIIIIIJJICBFHFGIGGIJHGHGHHHF?CFBAA9;>CDEDDDDDDDDBCCCCDDDDDDD
@1QB
AGCCGCTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACC
+
BCCFFFFFHHHHGIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHJIJJ=BEHHHHFFFFEEDEEDDDDDDDDDEDDDDDDDDEDDDDDDCDDDDDDDDD
@1QC
CCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAAT
+
@@CFFDFFHHGHHJIJJEGGHGGGIIHHIJGGGHIHGIJJJGIJIJJFFGIIJJIIJGGGIJEGIHGGIHHHHFHGDFFFFDDDDDBDDDCDDCDDDCDDE
@1QD
GCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTT
+
CCCFFFADHHHHHJJJJJJJJDD<BDDDDDDDDDDDDDCCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDEDDDDACDEDDDDEDEEDDDDDCD
@1QE
ATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCAC
+
@@CFFFDFHHHHHIGIJJHIJJJJIJJJJJJJJJJJJJJJJJJIJGHIJJJJJJJJJIHGIJJJJJJJJJJIIIHIIHHHFHFFFFFFFEEEEEEDDDDDD
@1QF
GACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAAT
+
?<@DBBDDFFFHH>G@FDHIHFGFEGHG9CAB?@EFEGIGGIIIIIIAHCEGIGC>DGGIEI=F@FHGI7@FH@GH>@DHBEEECHCB=BECF;AC;;@;>
@1QG
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
@@@DF?ADDFDDFEA@EG>FCFEFDHIICGGEGGGIIIBFCGDFAHBEGII?B>GGGHBDHIIICC=EGGEFA<5?=?>CA?C?B5<ACC5:@>C@9A<?B
@1QH
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@;@DDDADHFFBDHGIIIDAFHHHI>C;@?DGE)?DFAFCAFFGIIIIDGHHFHEHEEE?BCCCCCCCC>@:?/;@BC@@@ACCC:><@CCCCCA@@CC@
@1QI
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTC
+
@@@DDADDFFFHBIIIJJJGIDEHII@FEH9EFFHHGIGHHIBHII?7@AGC@;AGGIICE?CB=BBBDEDB;@;C@CCA?CCC3;?8@3:@CCC@CDCC:
@1QJ
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
@@@FFFFFHHHHHJJJJJGGIIJIHIIJIJIGHIIIIIHHIJIIJHEHIIJJJJIIIJJJIJIIJIFHDDD@@CECECCDDCDDDDD@DDDDDDDDDDDD
@1QK
CCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTG
+
@CCDFDFFDHHGFDGIJHJGGIIIIIJJIEGIIJIJIIIJIGHIIDEHIIEGCHGIHIIGIJ5;=BEFEEEEE>CBDBDBDDDBDDDDDDDDDDDDCDCDC
@1QL
AACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGG
+
@CCFFFFFHHHHHJJIJJJIJJHHIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJHIJJHHHHHHFFFFFEEDEDDDDDDDDDDDDDDDDDDDDDDD
@1QM
TGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGC
+
@@CDDDFFHHFDHGGEFHIGHGGIHI@HIEHHDGHJJIIDCE9BFGAFFDHGFGEB@AAE=BDFECCE;ACBACDDBCAAACDDCDCB@BDD?BDDCDDDD
@1QN
GTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAAC
+
@@?71:DDF;D1AEGEFC?HHFHFEEFB*?EGIE?F=F<BF@B?D?DCFIEFIIBFEEE@;.=ACCEEEDB@BBBBBCCCDDAAA<A?885<?:5:<BB:A
@1QO
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAG
+
CCCFFFFFHHHHHIJJGHJIGHFHIJJJJJJJJJJJJHIJJJJJJJJJJJJJIJJJJJJJJJJIIJJHGHHHFFDDDDDCDDDDD@CC
@1QP
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTC
+
@B@FFEFFHHHHHHIIJJJIIGIJJJJJJEGBDEFHHFGHHGIJJJDFGIAAFEGGI=EHEEFFF@;AECDDDDDDDCDDCCDDCDDBDDDDCCDCDEDDD
@1QQ
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@@BDDFFHHHHFHIGHJFGHIIGIEHGIGGG?FGGIJJIJ?FGHIFEDGEHFGIJIC@EECHHHHFDFFDDCD@3@CCCCCBD?DBBCCCCDDDDEC
@1QR
GGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIIHIHHHHHFFFFCEEDDEEDDDDDDDDDDDEDDDDDDDE
@1QS
GTCTTCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCAT
+
@@@DFFFFHHHHHIEFHHIGHJIJJIIIJEHHEHHIIJEIJJJJJIJIIIIIGGIGIJEIICCHGGGJJIJJIIIIJAGHIIJJHHHHGFFFFFFEECCEE
@1QT
TCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATC
+
CCCFFFEFGHHHHJJJJJJIJJJJJJJJJJIJJJJIJHHIIJJDHIIIIIJIJDHHIIGIIJIIJ@FIIJJJJHCEHHHFFFFDDDDDDDEDEDDDDDDDD
@1QU
ACAGGGCTCCGCGGCTGCACTTGCTCTCCGGGGCCCCAGGGCGCCGGCCCAGCATGGGCAGTTGCTCATTGTTGGAGATAAGGTCGCGCTGGTCATCCATG
+
@@@?=BD?FDHDD?D?@BBBDBBG?FHBHHI@;ABE<??DCA>?BB@5@8??BCCCB???5<>CACC@CA@DCBB@9CCCCC:+459<<B50?@>::ACCC
@1QV
CTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGT
+
CCCFFFFFHHHGHJJJIIIJJJJJIJJJJIJJJJIJJJJJJHIJJJJIJJJIIJJJJJJIIJJJJJAEHHHFFFFFFEDEDDDDEDEEDDDDDDDDCDEDA
@1QW
CCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCAC
+
@<@DDDDDFHFFDHB@DDBEBBGFGIG@G8EHIE@D?D9DFHEHHCFH>HH@BFCEDAHGIIBGCHHFHEDDECC>;>;;@CC@ACCCCBBBB@CCAA<??
@1QX
CGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACAAAGGTCAGTGGGATTGTAACAACCAGAAATATTCC
+
@@@BDFFFBDBFHBGGGICHGFGHGGHGEAGA@GHIGII?@GHHEGHGGGFE@>FHCGHICAF5=DH@HHHA7.;@D6@@;;@CCCCBDDDDDDC>DD>@
@1QY
GCTGTTGCTGCTAGTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTT
+
:=:BD?ADDDDFD+2,AFH@EAFE@G:8AEDHF@EF@G@;BFBG9FC?FCBF?DFEGAFGGI<AE).77;;)(((.;65>;;5@A(;:@AB99AB:A>ABB
@1QZ
CGGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCACGAGTCGCAGCACAGCTCGCTGGTC
+
@@@FFFDFDFHHHJJDHFHJJJFEHIJIIFIIIIIJJJJIIIIJIJJJJGJIJJHHHHGFFFFFFCEEEEECDDDBBDDBBCDBDD@BD<AACDDDBDB?C
@1R0
CATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAAC
+
CCCFFFFFHFHHHJJIJJJJJJIIJJJIGIJJJJJJJIIJJJIJJJJIJIJJIJIIGGIIGFHIIJIJHHFHHHFFFEFFFEEEEEEDDDEDDDCDDD
@1R1
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGAGGGAGGCTGCTGCCCAT
+
???ADDD3=CDADD=B@A@<3?CAE99EE=9?<??DACDEA<3*99@@D3?B37..))@)8AEAAA.758/5>='9>A>>A>(,5'8&&22((:(:+2>>
@1R2
GTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTC
+
CCCFFFDFFFFHHIJGHIIIJGIJJIIIIIJIJJJJJIIGJIIGFHGGIJIJJJIIJIGHGCGDHIJIEGCHIJJIIHHGAGGGHIEHHGFCEFFFFDCE>
@1R3
CTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTG
+
@@CFFBDFHDADFGGIICDDHGIGG9EEBADEGGGIIIEBFHIGICGHHGIG>@EA69BBBCC?B;;B@DCC@C@:A@?CB>@@C3>CDDD@ADCC4>@CC
@1R4
CGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCAGTGGGAGGCTGTCCATAAGAAGTTG
+
CCCFFFFFHHHHHJJJJJHGHJJJJJJJGIJJGHIJJJJIJJJJIJJIJJJJJJHIIIJIJHHHHHFHFFFFEEEEECEDDBDDDDBDDDDFDDDDDDDDD
@1R5
GGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGC
+
CCCFFFFFHHHHHJJJIJJJJJJHIJJIJIJJFIIIJJJJJJIJGIIJIJIJIIJJJJJJJJ=DHIJJHHHGHHFFFFDDDDDDBDDDDDDDDDDDDD
@1R6
AATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGG
+
@C@FFFEFHGFHDHGIIGIEIHHIIJHIJIDHGH?FGIFI?GGIIJJJIIGHJIJIJ8BCA@DEGGGEEEHHHGFFFFDFEEEECCCCACDDDDDEEEFDD
@1R7
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTTCCCATAAACACCCATGCTACTG
+
BC;DFFFFHHHHHJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJHHHHHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@1R8
GTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATC
+
B@@DFFFFGHFFHJIGGIIHHIJJJJJJJJJGGE@GIIJJJJJGGGHGIJJJJJIDGGIIJIJIIJGEHHHHHFFFDDFFFEEEEEEEDDDDECD@CDEDD
@1R9
TGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTG
+
CCCFFFFFHHHHHJJIJJJJJJJJIJJHJJJJIJIJJHJJJJJJ@FHIHIJJJJJHIJJHHFFFFDEDEEDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDD
@1RA
CATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGG
+
=@+=DDFFFAHFHIGCGGCFFDHHHIIGIGGIFIIIAGGGGEHCHEDBEGGAAHHIGHEECHCCBF7?BCEECEDE@CCBAAAAAC:?CCCCC>>>BBCBA
@1RB
CATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAAT
+
@CBFFFFFHHHFHHIIJJJJJIJJIJIJJIJJIHGHEEIJIFHIJIIIJJJIIJJJJJIHHIJJJIJIJJJJJIIJIJJIJGCHHHEFFDEDCEEEEEDDD
@1RC
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
CC@FFFFFDHHHHJJJGIJJJIJJJIJJJJJIJJIJJIJIJJGFHGJIJIIICHHIJIIFHHGF@DBEEDEEECEDDDDCDDDDD??CDDEDDDACCCCD
@1RD
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGG
+
@@@ADDDFFHFACGGGGEHAEGIII@EFIGEIEGGGGHGEC>FGGDGGGB<<FGB@FFG=@@GHIHHFFH@EFDD@DCEE@C@CCCCCB<?C@BD9>@0<?
@1RE
CATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGC
+
BB:DDFFFHHHHHJJJIJJJJJJJJJJGCFHIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHHHHGFFFFFFEEEDEEEEEEDDD@BDDDDDCDDB?
@1RF
CCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATAC
+
BB=DDFFFHHHHHJJJJJJJJJJJJJJHIJJJJHIJHJJJJJIJJJJJJJJJJDFHIJJIJJJJIJJJJJJJJJJHHHHHHFFFFFFEEEEEEDDDEDDEE
@1RG
TCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGT
+
@<;DB4BBF=DH@EA@GFHHCFHDFDGEEHGIGFBGIIFGGGE<CAAHEDDHHFEACEEBBEEE@CCCA@CA@CC@3@5:>ACACBB20<BC:ACC>4(:@
@1RH
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
CCCFFFFFHHHGHEGIJJJJJJJJJJJJIJJJJJJJJJJJJJJGIJJJJJJJJJJIIJJJJIJIJJJJJJJJI=BDFFFECEEEEEDDEEDDDDCDDDDDD
@1RI
AGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
::+4=BBDHBDFFIIIIGIEDFA@HHGIEHIG@EFHIIGIIGEHHBF<FBFBGFFFFHFHGAHGD@ECEE>;=ADEDECCEEC@@:@>?CCC@?859CC>
@1RJ
TTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTC
+
11:4=A2AADFB>FH@EGIGDHDFHIEHHBHHIIDIIGHCG?@CGG?FHGGI*?D>@F@GGIBBFHGHEH@F;CAD.=AAE@=A);@BD9;;:;;--;A;;
@1RK
GTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCT
+
BB1ADDFFHHHHHGIIIJIJIIJJJIJJIIJJJJJJJJIJJIIJIJJJJJJJJJGIIJCGHJIIEHJIJIJHHFDEFFEDEEEEADDDDDDDDDDDDDDDD
@1RL
CAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCC
+
@@@DADDDH?BA?EFGFHEEHHIGEIIIEHHFEHII?@?FDGIGHIIGHEHGIEHIIIGGAAF@GGEHGEEEHFEEEBBCC@CDCC@ADCCCCACCC@>CC
@1RM
GGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTC
+
@C@FFFFFHHHHDEGHIIIJJGIIJIHIGHIIGIIJJJIGIJEHGGFCHIJIIIIJIE=D=EHDEDFFECEEE;A@@BBDDBBBDDDDDDCDCDDDDDD
@1RN
TGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGT
+
CC@FFFFDHHHHHJIIJJJJIIJJIGGDDDD8@CCCC@CDDDEEEDDDDDDDDBDDDDDBDDDEDDDDCDCCCDDEDDDDDD5<>ACCDDDCACACCDDDC
@1RO
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTG
+
B@:BDDFFHHHHHJJJJJJJIJJJJJJJJGIIJJIJJJJJIJHIIIJIJJJJHJCHGHIIJIGIGIJIJIIHHHHHHFDFFDDDDDDADDCCDDDDDDDDD
@1RP
GCCGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
<@?DDDAAFBFFHDFGFGEHHGEGGGCGHIFCHIGGDBFDFFBBD;DGGGICGGHGHCCHIBCH?BBCDACBC,;@>AAACCCC5<A55?CCBA@59?CCC
@1RQ
CTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTC
+
BB@FFFFFHHHHGGIIJHIIIHIJJJJJJJIJIIIIJCHIGFGGGHHGHGIFHIIGGHIJIGIJJJAHIHI=FCHICGHHIIEIJIHHEHECFDFDECC>A
@1RR
TACCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTT
+
1:14ADDFHGFDFHEHGGGII@I@HGGHII=@FF@CBFD?:C:DAFD@B0B?FBGH@F<FHDBFBFDDGHIIBBAD;@F;CDH>D@EHHF>=ADFB37;@A
@1RS
TGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGG
+
?@+=BDDFDHHHDGIIJIIJJEHIGIIGIIIJJJJJEHIIIJGI;FHGGGHIIJJCFGGCHBHCHEDDCEFCEEECEDD?BDCBDDDDDBDDDDDCCC><B
@1RT
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCC
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFFEEDD9?BBDDDDDCDDDDDDDDDDDDDDDDDDD
@1RU
TTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCA
+
C@@FFFFFDHBBCGGHIIBCFHIECGGIGEHEBCDGGGIHCBGIEHIGIIIIIIIIIIIIIIGGHIGHE@EHIGHFFGHHFFFFFECCECC@CCCC@CCD
@1RV
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
@@<DDDDFFDHHA@GEFEEICFEFEEHCEFIGEDHHIFBDCFHHFFHABHCCGEGI-:BDFDCE@>ABBDBDCCCCCCCCC@ABD>9>BDDDCCDCCDDC@
@1RW
GGTGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGC
+
??=BA:B?<<DFBDHGEA3AAEFHGGG3CFBEA*8C@)8@?D>9?FHIGA@DGE?;AB5/9>;6;@>?6,8,,;@5>;5:(:::::<:99ACC>@:AC@>
@1RX
AGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGT
+
@@;DDFEFGHGHHIIGJIIIIIJJJJHIJIJJIIJJJFIJIGIJIJJJJJJJJJIJDGGIJJJGFHIJJJJJJJJJJHHGHHHHHFFFFFFFEEEEDDCDD
@1RY
TCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGGGACACCCTCAGGGGGGGGGCATTCTTGGGCAGGGGGAACACCAAGTCCTCTGTT
+
BB:BDFFFFHHHHJJJJIIJJJJJJJJJJJJJJJJJJJJJIJJJJJ5''',,2&(+(++2;@;-&)0&(+(+(((2(()-5>-&)((+((++((+((((+(
@1RZ
GGTTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCT
+
@@1ADDEFHHDHHHIIHHHHIJJJGGIJFHIJJJJIJIJJEHIIGIGHGHGG>HIJGHJHHEHFDFFFBEEEEDECACDDDDDDDDDEDDD5@CCDDC>@C
@1S0
GGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAA
+
=?:ADDDDHFAHFGGHH:A?I?DHFCHIGGIIIGIIHGHGECGGCFHI@GGIIIGHGECGHIIIEGHC8BFG@FGG@FG@@EGHF);A?@;BBDCECCCC
@1S1
GTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTTCTTCTTGCTCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTTTTTCTGGGGACAGCAGATCT
+
@CCDDDFFHHBFHIJIJGHGGIJGIIIGGGIGHIJIJJJJJIGIHIIJJIIJJJIJIGHHJFGIJIJIIHHHFFFFFFFEECECCCDDDDDDDDBCBCDDE
@1S2
TATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTT
+
BCBFFFFFFDHHHJIIJJIIJJJJJJHHJJJJJGIIJJJJJJJJJJIJJJJHIJJIIFJ@FGIBGIIJEDHIJIIHIJEHHEHHFCFFFFDEEEEEDDDDD
@1S3
CGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCC
+
BB+BDFFEHHHHHJJJJIJJJJJJJJJJJJIJJJJJGIIJJJJJJJJJJIJJJJJJJJJJJJJJJJJJHHHHHFEFFFFFEEDCDDBDDDBDDDEEDDDDD
@1S4
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
?@@DDDDDFH>AFHF>AHF8?CH<CC3:99??F9DGIIGAG>=DEB3BBF;=@77..=D;27=A:?;@?DC<@C(5;>>AC@(;;,5<3:@(:35>CC>>@
@1S5
CTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTT
+
@@@?ADDDD2ADCBCFDACGFE@HGI?FHHEGBFHDHD<ED?DBF?DHDHIEFEDB??BB?B?BFDDBFGFBDFCDH7@G@HI77=??>E7=;BCA?@?A>
@1S6
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGT
+
??@BADDFHHBFGHIIIGIHIGIIGIIIIIIGGFEHGEEHEHIIIIEIIIGDHGIIIDBBDCCDDACCCD>CCDEDDABCCDDBDD?BD<CDDEDDDCDDD
@1S7
GCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATC
+
@@<DDFFFFDHFHIIIIGHGIJJFIJIJEEGIICFHJIGGIIHIHGHIJJJIJJGIGGHIJEIIIJGEGHJJJJHGHF>BEA>CC@CDDCBDDDC@CDCD@
@1S8
TTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGT
+
@@@BDDDFFDBFHHIIIICHHHGHGIIGGGHHHBBBEHGBA??FF>CHIGEFFGGIIEFGHIHCHIIGHIDBFGGIIIIIIIAECCHFHHFFEFFFFFDC
@1S9
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
@@=B;DDDBFHBDIEI@EF@EHG>BGCGEB@8638AACC>?83>8>CCCCB9>C822&<?B@CCCDC:A@CC@3>A>@::4>B@09>C>A8A9?CC449?
@1SA
GTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAA
+
@B@DFFFFGHFHHAGGHGHEHJIJIJJDDHFIIJJIJIIGI>GGJGGIHIGIEHGHIIIIJJHIGHIIHHHIHIIHHHHHFFFFFFFEEDDDDDDCDDDD
@1SB
CTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTT
+
CCCFFFFFHHHHHJJJJJJJJJJJFHIJHIJJJIJHIJJJJJJJJIJJJJJIHHHHHHFFFFFFEEEEEDDDDDDEDDDDDDDDDDDDEDDDDDDDDDDBD
@1SC
AGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTTTCTCCAGGACCCAGGGAAATGTTGCCCCTGGAGCCCAGTCCCTGGCAGCCTTCCTGATAC
+
@@@BD8;DBCDDF@H@GH@@C:FG@C;EECCF9??F>F9BDG><DF93(;BBB@FB;2=CDHE;ACCEH;.;(6=?AA>;@CCCAA?8?A9@CCC@A:@>
@1SD
AGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGT
+
@@@=DDBDFA;C<@EFE>GDCABHGG@EHIB?CF>?DHHED@DDFHGIE@HHHIGGDBFAHIIFCHA>ABDBB>AC@ACCCCCCB;A@@(,8?CCC?C?<2
@1SE
GATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTT
+
CCCFFFFFHHHHHIJIJJJJIJJJJJJJJJJJJJIJHIIIJIIIJJJJJJGIJJIHJJIGHGEHFFFFFDDEEDEEEEDDDDDDDDDDDDCCDDDDDDDCC
@1SF
ATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGC
+
CC@FFFFEDDHHHIIIIJGIJIIJIJJIIJIIIJJJJJJJJJHGIJGIIJJGHIIGIIJJIJJGIHHHHHFFFDECC@CEEEEDEDDDCBDDDDB:>CDC
@1SG
TGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGGAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
<?<?DDDADD?::2+1<E@D<A2AD?9)11?DEDDE<)0?0DAAD(=AC37A;CCC5=ACA);AD>;;=@=>A>>?=7331,;:>8>32(4>>>>><;85
@1SH
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGT
+
?@@D=B2==FFFFF<GFBFEFC<A;AFG::?CG9:DB3BD0?F3?B<?DFEIIIII;@;CAC'--;>BB;>BB>66>;;===82(::>>B>@:4>A@BB@:
@1SI
CTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
@@@FFFFDHHFHF<BFFHAGGHDBHEFFHGHBHEE<D?F:?FHHIHIIIIIIIHGHECCDHE@G?@?7=?ED;7?;5=ABDCDCD>CBACC@?88ABCCC4
@1SJ
GTGGGCTTTTGCTCCAAGGAGTGCCTGCTCATTTCAAACAGGAGCCAATGGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTT
+
@@@FFFFDHHHHHIIJJIIGGFG>AFBGDGIEIGIIIJIGCDHHJGIEHGIFHGIIDGIGIICIIJIJIIEHDHCEFD@DFDDECCCC@CDDDDCC9?>AC
@1SK
CTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTT
+
1?@DDDEFFHFFHIGIIBBBIHECAG:CHEBHGHHGF@@EHGGE>DG@FHIAFHHHGGFBFGBFHGEGHIBGIIGIGICHIAECEEEEEC?CDFFBDDECC
@1SL
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
C@CFFFFFHHHHHJJJIJJJJJJHIIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJGIIIJJJJIJEHHHHHHFFFFFFFDDD3=BDBCDDEDD@CDDDDDD
@1SM
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@@DDADDDFDFBGHGIIG9A<FHGGGIIIGCEHCFBBHGEGHGGHIIGIIIIIC=FG@FGGEECA?EEEED@@C@CCC;A@?CCB?8><BCCCBCB?2<C
@1SN
CAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCT
+
@@@FFFBD?DF>F?FGGHGGIJDIGHIJJI?EHGHHI>F9CGGHEHJIGIIHIGHIJCGBHIJGHJJ=BDDDEDC@;=CC>ACDDDCDCCCACDDDDDDBC
@1SO
TAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGC
+
@@@DDDDDBH><CEAFHIIGABH@@?EH<E9<FEHGHEHACBGDEAG???D:6;;@FHEAEGEHCEHCC;C77?6>>@@CCCCCCCCC88:??CC@:@CDA
@1SP
TGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAA
+
@@@DDA;DD?D<CFHBGIIIIEHEHE7C?@FDHCHHG<<?D8FDDEC<FFEIGGHF>CEDEGEHAEAHECDBDCA@C@CC@@CCCC5<(::?BBBBCBB<
@1SQ
GGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGACACCAAAAGACCATACATCACTTTGCGTGGTGTAGATATGATCAAAAAGGGATTCAATTGCC
+
@@@FDDFFHHHHHIJIJJJFJJFIGGJJJIIJIJIJIIIEIJIJIJCHGIJIJJEGIEHHHHHFF?BC?BBCCDDDDDEDDEDDDDDDDDDDDDEEEACD
@1SR
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
@B@FFFFEHHHHHJJJFHIJGHJJ<EGIIJJJJJJFHIJJHJJJJJJIJJJJJJJJJEGHHHHHFFFF>CCEEEEDDDDDDDDDDEDEEEDDDDDDDDDE
@1SS
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CCCFFFFFHHHHHIIIJJIGHGHIGGHIIIGGIIIIJIIIIJIEIIGHIIIIEIHJJCCGIJJJ5=BA9ACCDAC;ABBDDDBDDBCDCDBDDDACDDDDD
@1ST
GCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
C@@DDFFBHHHHHJJJIJIGEFGGHIJGGGIGHIJFGGGGIHBGHGJIIIIHGG>?EHDDCBDDCDC>CDDCDDDDDDDCDDCDDCCCCDDBBCDDCCDDD
@1SU
CGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCCTGTTGGAGAGAGCATGAGGC
+
@@?DDADDDH8FFH;FIGDGHAHGGHHIGHEFGIIGIC@FGCHGCGHFHBFFGGGHGFGAHG>E==DAEAAH@HDE@BCC<@BCCCA@?3<???C>CC>A0
@1SV
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
BCCFFFFFGHGHGJJJJGIIJJJJJJJJJJJIJIJJJJJIIIJIJJJJJJIJJJJJJJHHHHHFFFCDDBDDDDCCBDDBDDDDDDDDDDDDDDDDDDDDD
@1SW
TCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGAC
+
<@@FDFFDFHHHHIGGIH@@E?FHHGIIF@HGIIIG?3?DH<D?F@GFFFHGBD@>CGGA>DGCGHHHGG=C=BB>@;?C:AC<?ABBCCCCBCCCCB?C?
@1SX
GGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTG
+
@B?DFFFFHHHHHJHIJJJJJJJJJJJJJJJJFGIJJJJIJJJJJJJJJJJJJJIJJHHFFDFEDEDDDDDDDDDDDDDDDDDDDD>BDDDDCCEDDDDDD
@1SY
CCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTT
+
@@@DFFFFHFHFHGFHIGGIIHJIDHGIJGIIDHGIEDGHIDGIIJJGIGGFGEIIJGGGHDCGHIFGIJGGGHHFFDEFACACEEDD@CAADDEDDCCCD
@1SZ
TAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCC
+
?@<DD>BDDFBHDHIEGHFH>@?ECDG@???BG>BEF@GGCGFB>BC=@DBAEHHAAE@DB:;>;AEA=@>CAC@C5@:ACCCDC?BCD??>@DDD>CDC?
@1T0
TGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTG
+
?@@DADDDFHHDD2AFGEIHGGHGIHIGIIGHIGGGIJJHIJGIEIJGIJJGHGGIICGGDHIG=DHFEHHG?CDCDFF;;;>AC;@B;?8?ACDCEEDDA
@1T1
CTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGG
+
CCCFFFFFHFFHFGIJJIIIGIIJEHIIIIGIIJJHIJJJJGIJJEIJIJJJGIIIIHHIJIJJJJJGHHEFFFFFEDEACEC>BCDDDDDDDDDEDCDDD
@1T2
GTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTG
+
CBCFFFFFHFHHHJJJJJJJFHIJJIJJJJJJJJJJJJJJJJFHIJJJJJJJJEHJJJJHHHFFFFFEEEFEEEEDDDDDDDDDEDDDEEDDDDDDDDDDD
@1T3
GTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTC
+
@@@FDFFFFHHHHJJJJJJJIIJJIGIJJJIHJIGGHIGFFHIJIJJJIIIGIGJ@CGIHGHHHDFFFFEEDDBDDDEEDFDDDDDDDDDCDDDDDDEDDD
@1T4
GTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTT
+
?@;BDDDDFCFFHGGGHIEHGIICGEFEHIIIIIIGIIIFEIG@GHGBF<CHGIGIIIHHHH;CDD@DEECCCCDCADCCCCCC>@@CCACCACCCCBBBB
@1T5
CCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATA
+
CCCFFFFDHBHBFHGEHHCFFHHGIEFHHHIIIIIFIIIGIIIGIIIIGIEGFGFAGGGCFGG=CHIHEEHHFFFFDDDADDDDCDDDCDCDDDDDDDD
@1T6
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGATGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGG
+
@C@BDDFFHHFBAFGIGEFHJEIJIGGHIGFJFIGGHGIII>GHEHGIG@DHIDIIHGG@DHHEEGHHBH;EFFDE@DEEDECDCDCCDDDCBBD5;@BBB
@1T7
TATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGG
+
?@=DBDFFGFDDHIIGJJJJJJJIJFIJJJJIGIHIJJJJJIFHIJIGIIHHHEEFFFDEDEDEDECDCDDDDDDDBBDDDDCDEDDDDDDDDDDDDDDDD
@1T8
ACTCGCTTCAGCAATGCAATGATATGTGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCT
+
CC@FFFFFHHHHHJJIJJIJIGIJJIFHHIJJJJJJJJDHIIIIIJJJIJJIJIIJIIIGJJIIJJJJJJJJJHHHHHHFFFFFFBEEEDCEEDDDDDDDD
@1T9
GGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGGGTTCTGCTG
+
@@@DDAD<A<AFCAGHI?AAF??8:9C*)0*?*0099?9?9/0B8)=88=8CC78;.=E7=77).777))).;.(65/53395::(,(((0)0<C>CC3
@1TA
GTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGC
+
@B@FFFFFHHHHHIJIJJJJJJJJJJJJJIJJJJJJJJJIJJJJJJJJIJIIIJIJJIIHIIJJIJ5@DDACDDEDD@CDDDDDDDDDDDDDDDDDDDDDD
@1TB
TTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTT
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJIGGIJJJIJJJJJIJHIJIGGHCGIIGIIJJJIJJJJHHHHHFEFFFEEEEEDD@D
@1TC
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGT
+
@@?DDEDBFFFDBHDGAFHGHEFHIGGIIIGBEHHGDDFEFGEFHIAH<=CFGIICGEGIGGGHHHABB@C@DEAABBC@@BCC<>CCCCD@CCD?C@@CD
@1TD
GCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
C@CFFFFAFHHHHCGGIJJIIJIJIHIIIIIDFGIIIGIIGGJJJIDDGHJIJJJJJEHIIJJHHHFEEDCAECDDCDCDDDDDDDDDCCDCDDACDCCD
@1TE
CTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCT
+
C@CFFFFFHHHHFJIIJJJIJIJIGJIJJJJJJJIIJJJGEGIIGJJEIJIIIJIJJJIJF=FDFGGJIGGHHHFFDFEDDDDCCCDDDDDBBDDDCCD
@1TF
CGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
?;+4B?DDDHHHFIIGEG9BHEHIID@C@;FD:?DFBCCHIAD@FGDFGGBBFIBB@FH@@@A77?>AB@BDCC;;>@;@C?CA8;@CBB@CCBCBB8?C
@1TG
TGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTGT
+
@CC?DDFDDHHFHDGFGIIIGGEHIJEHIIIGIFA;GHDDGIIGBHIIJGDHIIIJHFGGHG?EHDHB?C=;@C@?B@BBBBDCCCA>9?CDBBBBBD>CC
@1TH
TGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGGAGG
+
@@@DBBBDH>FHDBFHIAGGGIIGIGFFFEGGGHIIIIBDHE??FGHIIIEHIEFDHGGECGDH=FHIHEE?CDDCCCCCCCCCCCCC3>CB>CBB&5>@
@1TI
ATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTC
+
?@@A?:===C<FBGIB@?GBEB<C?E<AAC:?:?FHIE6F@<F;FF=C.8/8@@G@:??;?;;;6;A@;;;>>>;:5,599:>CC>:3>CD@>C:+4444:
@1TJ
CTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTT
+
@@@FFFFFHHDHFHIGIIHIIJJGAHGJIHIJJJI@FGHGIIHGHEFEFFDCAECE>CBB@CDCDCECDCCDDCDBDCDBBDBDCCDDDDDDDDDCC@AAA
@1TK
CTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTG
+
@BCFDFDFHHHHHJJJJJJJJJJJJJJJIJJJJJDGIJJJIJHHHFFFFFDDDDDDDDDDDDDDDEEDDDDDDDDDDDDEDDDDDCDDDDDDDDDDDDDDD
@1TL
CAACAAAGGGGCAGAGCCTCTGAAGTCCTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTT
+
?<8=43:B?7C@DBE:+<ABF9*:BE9CEBBFC*?F;BFG8?DAF?9<@FFBFEE@AEEFF;98?@@B?@33;AB@:?BABA@>:4++:4>:>>AB>:8+:
@1TM
CCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGACACCAAAAGACCATACATCACTTTGCGTGGTGTAGATATGATCAAAAAGGGATT
+
??1A=2B>DDDD:<1:C::A?)8?31CC3?DDDCB<@9B@B?;B2=BCDCIADCCDDD9@;;;;;>;;;A@3>;;=6,8<AA::>A3:4>>A>><.0(8<>
@1TN
CTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAAT
+
?11ABBBDDBF:<EG3?E@DGGH<AAEDFC4<E?*?E9B****C<DFE4??BBF??DBF>C@@@C.=1=D7=;CA@EAC)(.;;?;>3(666>:>:;>A:>
@1TO
CTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTT
+
CCCFFFFFHHHHHJJIIIHIIJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJHHJJJHHHHHHFFFFFFEEEEEDDDDD
@1TP
CTTGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
@@+AD=DEHHHHHJJJJJIJGIIIIJJJJJJIIIJHIJIJJJJFIJJJJJJJJJJJJJIIJJJII@FHEHEHHHHHHFFFFFFFCEACDBDDDDDDDD@BB
@1TQ
GTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGGCAGGTTTC
+
@@@FFFFD<>DHHIIGGBGEHIIGGI@FHCHIIIIEGC::ACDFCEEDC>CC6>A@CCCCD9=BABD3<?B5;BBDCBDDCCB8CB<<BBDD-<9@B+>AC
@1TR
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@?DFFDADDFFDIIBFBGGCGHHGIBAFE3DDHC>B<DAHFGGCEGFHE>F<BEAGCCECHE:D=C;C?;?B;@7;@CCCB'3=B,:9>CCC(:AA8?>?
@1TS
TAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCC
+
C@@FFFFFHGHGHGIGHIJIE@CEDGHGEDHHHEHIJJJIIGGGIJGIEGHIGEHFHFEFEEEED>CEBCACDDDCACCCCCD>ACBDCDDDDDDDCACCD
@1TT
GGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGT
+
CCCFFFFDHDAHHJJGGGHGHEHIJBDHGIHEIIJ=FG/BEEEDEDDFECBEECDD>CCB@@BBDDDDDDDBDBDDCDDDBDDCDBB??BDDDCDCDD+8:
@1TU
GGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGT
+
@@CDFFFFHHHDHGJIIJFFHGIGEHIJJIFGIJIIJJJI@FHGIIEHJIG@GHIJJJHHFDFFDFEEDEECEDDDDDDDDDDDDDEEDDDDDDDDBDDDD
@1TV
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATAT
+
@?@DDDFFFHGHHIIGHIICFHIIIIIIIIIIIIIIIHHHIIHFHIBHGGHFHIGIECC@@AAEFHHGFF@DCECEEDD?CDDDCCDBDDBBB@ACCCCCD
@1TW
ACCAAGAGCTAAGCATTTGTTAAAATGAGTGAAAAACTCGCTTCAGCAATGCAATGATATGTGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATT
+
@@1DBDDDADDDBEEIIDHFGBCECGGICAC@HCBFG@DEGHDFGG@GHIHIGHIGCDHBC=CHGH;ABA?D@ADCDFFCD;AECCCCCCECDAC@CCACC
@1TX
CGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGG
+
===B;DDDDFA:6DFADFFIF>;B8@@=F-;CEFFEFFFDDD?BBBBBBB@5:ABBBB@?9??B&5)8@BBAAB>@AB95&0)9559?ABBB<??B>
@1TY
CTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTT
+
=B1=DDFFHHHHHIIJJJJIJJJJJJIJJJJJJJJJIJIJJJJIHHEHDDFFFFEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDEDEEEEE
@1TZ
CTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACC
+
CCCFFFFFHFFHHJHIIGIIJIJHJJJJJIIGGIJJGIJJJJIJGIIIIIIIIFHCEEEHJJGIEGIIJHHHHHHFFFFFFDDEED>CDDDDDDDDDDDBD
@1U0
CTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCT
+
=?;7+:?BDD8?D<)<C<C+<ACE?<EEED@EICFBF9DBDB93D@D@:D3==B4;68@@@A@@7=ACDDC7ADD@.?B;@>;(,588'8?:)5>?5:(+>
@1U1
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATC
+
@@@FDDFFHGGHHICGHIAHIJACFIGHJJJJJ@FGIJHJJJJJJIIJIJJJIJJGGEHHHHHHFFBEDEEEEDBDDDDDDDDFDEEECDDDDCDDDEDDD
@1U2
CTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTG
+
CCCFFFFFHHHHHCFGIIJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJHHHHFFDDDDDEDDDDDDBDDDDEEDDDDDDDDDBD
@1U3
GTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCT
+
@@@F?DD:D?FHHGHIIIIIIIHAHGEHGGIGGHIIIIIIGGIIGIIIIIIHHHE@HFDECBEEE;AABB38,:@CCCCCCCCCCBB@BBBBCCCCBCCCC
@1U4
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCT
+
;@71AADDDFH?4EGGCDFHDI@?FFB:9C*1:D@FGII?DG;??F1);6CH>;677@AG)=;/?C>>;);>A3(;(5>@((,5(,>;5>(((:(:3@A((
@1U5
GTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTC
+
CC<DFDDFHDDHBGHDFEHHIIIGGIGIJJIHIJGGIJI@FCCH@EHIIGHIHC:<?ACCCCDCCD?CCCACA>;ACDDDDCDDD8?BDDDDDDDCEDEDC
@1U6
CACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGTGAGGAGGCTCTCGCACGGCTCCGCCCGCTCCAGCGACTCTACGCTGAACATCTTCC
+
@@@DDD?DD:A<A+AFFF<<3:?+C+A2A4*:911?C*:93***BB4?B>FD18.=);(-;':='',9/53382;8(:(0&)5>B:A?&(05:>44>(:(:
@1U7
CAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCT
+
?@@1ADDBFB:ADF:<E<AC+<A1CB?C??294C9*?*:19?F@9?@B9?4?F?)?98BD@?7;FFEFAF3@;@)7=>EEE>77;;;62>>>;((5-555(
@1U8
CTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCT
+
CC@FFFFFHFDHFGIJGJIIIGEHGGF?9ADEEG@GHII>EDBC11C*:90000077F?<FCEF=CG.@EAE?-?;)?@;>CDAC>AEDDDDCDACCABCD
@1U9
ATTAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
BB+ADFFFHHHHHJJJJJJJGHIJJJJJJJJJGHIJJJGIJFHIJJJJJIJJJCHIJJJJHHHHHFFFBEFDDDDDDDDEDDDCDDDEFDDDDDDDDDDDD
@1UA
TGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCC
+
1=?;BDADFF:DBB<@AEAA>FCF<A<<AH<H>EA8?9BFF@*?B?9DFFFFFAEEEEFEFAEFBE=?DBD?@@>A@@>@@B
@1UB
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTG
+
@@CFDDEFDFHHHHIGGG<@FEFH@CHFCHGEFGH?FEGIHG9BBFGEGHHIGGI<CFHIIIIIIIIDGGICHGHHH<?DFB>A/?>@;ACCBBB@ACCCC
@1UC
GGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJIJJIGIJIJJIJJIIJHHEHHHFFFFFFEEEEEEEDDDDDDDDDDDDB
@1UD
GTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTG
+
B@BFFFFFHHHHHHIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJIJHHHHHFFDEFDEEEDECDDDDD<ACEDDDDDDDDDDDDDCDDDD
@1UE
CTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTG
+
CC@FFDDDFDFGHIIJIJJGJIJJIIGGIJJIJJIIDIGIIJFHIIJJJIIGHHHGCFFFEEECDD>BBCCDCCACDDDDDBDDDCDCDDCDCCDDDDDCD
@1UF
CTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
@C@DD>DDHDFHHGIJGIHGHGHIIHHHHGHIHGHGIGGIIGIFHGIIJHGGHIIIIGIJJJJIIFHGGEHFFEFDC@CAEDDCDDDDC?ACB@CBD2>?B
@1UG
CCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGT
+
?@:BDDEFHGHGHJJJGGHAFGHIJJJJIIJJIJJJJJGIFHGFHHGIJ@GHGIHBCCBDDDDBBDDDDDDDDB@BBD@CEEDDDDCCCCDDDDEDCDDDC
@1UH
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCG
+
::8B48DDFHD4DC<F<:3CCFEGFHGE9?<BGH?GGBBBAD3*9?BB*?<DAFCGEC@=@@))=DHCCABCHE7?;?>>>@>@;?B=?A?9ACC:>CCB
@1UI
CCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCT
+
@@@FFFFFHHGHBHEGHGIIGGIIEGHEHHGHIFFFHIGGCHHGIJJJGIEGIHDGIGJGIFGGHIGIIJIIHEGHIIEHECHFFDEFFBBBEECECCDAC
@1UJ
GGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
@C@FFFFFFHDHFBGHIJBEHIGIIHHHBFEHJIJ<BFGJGDHACFDHHJJBF@CGE@;@FGIGIGHEHHHHHCEDFDFDCCDBDDDDCDDA9?BBB::@C
@1UK
GAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGG
+
@CCDFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJ?FHGHIFHIJJJJJJJJJFHI@EIBEHHHHFFFFFFDEDEEDDDDDDDDDDDDDDDDDDDDD
@1UL
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CC@FFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJHHHHHFFF>BD?DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@1UM
GTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAAC
+
@@@DF>DEHDFB<CFEHEHIEHFEDEEHIIIGIICDBDGGFGICC?DGIGGCE@;@D@HGIICH=CCEEFFFFEDFECECCECCCCCCB<<C@@CCB<AAC
@1UN
CGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGT
+
?@<DDDDDDCFHABHGGDGI<FDGEHFEFHIIEEGHGHGGHGIGGGGIGB6BA@CCCEHGIGCEECAEDCBDEBCCC;?BCCC>ACCCADCCDE@CCCCB8
@1UO
TGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGC
+
@@?DDDDAAAAFF?ECC?@8<2<??GG?CGDGA;:B?;FDDB?B?DF</9BFB=CACFFAA@E=6C7.55,,3>6@;5((-55:555<BBBBB@B?88:AB
@1UP
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
@@;ABDDDFHHHGJJIJIIEHHJIJGGHJJIJIJIIFGIHIFGIIHGGEEGHGGGGIGIJIGIGI=EHIEHHF5@ACEEEDDDD?ACDDDDCDDD@BDDD
@1UQ
TGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTA
+
@@@FFFD?FAFDAFGEHB@GHIIIICCGHIIBDEG8?B7<B;C===@F7@GED;CCHCEEHC);BBCDA>@C;@9C?A@CC>:A?:A@A@C@BB909<0(
@1UR
TGCTGCTGGACATGACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAAAATGGAC
+
?<?;DBDDHDDFFBHFHICHIGGGIEHGIAEH6AG;CC?BBED?BAB?>>CBC?@>CC@C;:CCDCCCDDC<:?CCC4>@CCCAA@>A<>B<AA9A>ACCC
@1US
AGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGT
+
CCCFFFFFHHHHHJJJJJJJJHIJIJJJJJJJJJJHIIJJJJJJJJJJJJJJJJJJJIIJJJJHHHEHHFFFFFDEEEEEDCDDDDDDD?CDDDDDDDDD<
@1UT
GTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGT
+
@@@FDEFFHHDF>GBGBBHH=ECBFGI@CHGHIIIEIG@GGII??FHG?DHEHIIIDGBB>BGH@GG@DHHHGIIGHFHDDDEF@EECDDDD>@CAB?AA
@1UU
TCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJFDDBDDDDDDDDDDDDDDDDDCDDDEDEEEDDDDDDCDDDDDDDDDDDDDDBDD@BCDDDDDDDDDD
@1UV
GCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTG
+
??=DB:DD:?DCFGEFFHIEGD@EEF@C?@FC::::BDGIA??BHEHACFHIIG>FII;@AAA->??;=(6;8=C=?>A5:3@>@C<B?@@1?39:@?CC
@1UW
CTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATCTCGTATGCCGTCTTCTGCTTGAAAA
+
BB@FDDDFDFGFFGGIIIIFIIIHEIIFGEGIDIIGHIJIBGGIGEHEHHGHDFF?ECCACACCCDC@C@CC>AACCBBDD?C:959<@DCCCCCDBCCD
@1UX
CGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGC
+
?77DDDDDDD3C2ACEEB4FA+3A:CF4+AFAEFBCB3)C?DDAD=BDDD>BDEI>EEIEDDB=8B<@)87;7@@DEEECED>;.=C);@?@DDAAAAAAA
@1UY
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCAT
+
@@CDA;DDHFHH?HEHIIGHEHIIIIIIIEEGHCHIIDDHHHGIGGGCGHIIGIIIHFEEEFFFFECECEECCCC@CBCCC@CCCCCAACCCCACCCACCD
@1UZ
GGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTG
+
?@?DDDDDHHHHGJJIIJIJIJGIFHIIJJIGHHIEGIJEGIIIIIEIJIIHIIJHIJJIJIGJIIJI;@EHHGHHFFFDDEEED?CCC>CA>CCD?BDDC
@1V0
CTCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
@@@FFFFFGHHHHJIIGGHGFFGGIJJJIJIIIIIJIGGHGIGEHHGEHJJJJJGEHFFFDDDDDDDDDDDDABDDDDDDDDDDDDDDCDDDBCCDCDDDD
@1V1
GGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTT
+
C@CFFFFFBFDHHIIIIJJGIIJIJEEIJIJJJJJJJJJJJJJIIJFEHIIJJJJJJJJJJJJJGHHHHDDFFEDEBEECCD?BD@BDDDDDDDDDDDDDD
@1V2
AAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTC
+
?@?DDDEDHDHFDFGG<?<IGFECCHEGGDFCHHEIEGHHBDB?38?;D;@FBDBEH?A@FH@@F@CEEHGCC;=C>CEFFBC?BD@CEACCEE?BB;8@C
@1V3
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CC@FFFFFHGHHHJJJIIIJIJJJGHIHHJJJIGIIJJGJJJJJJFHIIJIIJJEHHFFFFFFDCEEEEDDDDDDDEEFEDDDDDDCCDDDDDDDDDDDD
@1V4
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CCCFFFFFHHHHHJJGIIJJHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJHHHHHFFFFFFFEEDEEEDDDDDDDDDDDDDDDDDDDD<@D
@1V5
TTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTT
+
CCCFFFFFHHHHHJJJJJJJJJIIIJIJJJJJJJJJJJJJIJJJEIJGIJJJJJJJIIIJJIGIGHIJCHHHFHFFFFFEEEEED?BBBBD@DDDDEDDEE
@1V6
TGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTG
+
BCBFFFFFHHHHHJHIJJJJJEHJJJJIIJJJIJJJJIIJJGHIIJIJJJGIJ?GFHIIJJIJEIGIHIJIIJGIIIHGHEHHFFBEFFEEEEEEDDDDD
@1V7
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@@@FFFFDFGHGHIJHHCGHJIGGH@GGHBHGFHEEGEHDH?BGEEHEBHGEGID=FHHIIAFEIIGGIHIIG?HGHEFBFABB;ACFDCCBABACCCCDD
@1V8
GTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGAT
+
@=?DDFDDHHHGDH8GIHHGDGGGHGFHIGGGEHGGFFFFD=;=ACDDDDDDDDBDDBDDDDDDDCC?BCCBD?B99<<?CCCDDC@CDDBBDDDDDD<AA
@1V9
GTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTT
+
=?1ADDADFAFAFB@FBG4CE@FA9FGEF19CFBF1?<D@D@BGF<DFFG<<D>FF>FCFDFGEEF=@DECGI=FEFEICC;89=BCB?BB6<AA>ABBB@
@1VA
CTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTG
+
B@@DDFFFHGGHHJIJIIJJIJIJHGIHIJJIJJJEHGJJIJJJJJIGG=CEHIJFGHIJJJIEHHFFHFFFFFDEDDECCDDACDDDDDDCDDCDDDDD
@1VB
CCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGG
+
@@@DD:+=DFDFDF@FGFEH>E?FEFCFGIIIFF>@DB8/BFFFEFE;AEFDFEF=76.;@>@??A36;;@A>AB@@ABBABBBBAB:>B@<?@?B@?<28
@1VC
CTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTT
+
@B@FDFFFHGHHHJJJIJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJIJJJIJJHHHHHHFFFFDDEDEDDDDD
@1VD
GTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAAC
+
?@<D+2=ADA:CADF<<CBBFGFE@:EHEH?FGAFF<BB>:DGD9?B?9BGFEEGGFGIG?BF<B;@FA5=77@EEFFF<B;@BDBCCA>@BAAA@AB>A?
@1VE
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@@<DDDADCFHFHIIFF8C@FEHFGII<ECEH*CGG;DFHGIHGHFDH)=BGAHGH@CCE@CEEE:=BBD>BBB6>CCCCCCEA>C@BACCACCC?9>@CC
@1VF
CTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGT
+
CCCFFDDFHGHHHJJJJJJJIJJJJJIJJJJIJIJIJJJIIHIIJIJGGDFHGDHJGHEHIJGHIJ=AHHHEFFDFFEDEDBDDDDEEDCDDDDDDDCDDA
@1VG
GACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTG
+
@@CFFFFFGHHHHICGHIII>FGGGIFIJJIJJJIIJGHGIDG??DGEGIBEHHIHDIDAGIDECEHFEHEHEHCFDFFFFCE;A?CAD?BCDCAADDDDD
@1VH
CCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCG
+
@CCFFFFFHHHHHJIIJIJHIIJJJIJJJJJJJIIIJIJJIJIIJJIGGHIJIJJJJIIIFEIJJIJJJHHHFFCE@DFFFDEEEEECEDEDDDDDDDDDD
@1VI
GGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTG
+
@@@DDDADAFHAH@EE>ACGEE@;??FBD:?FCH>CEE?FFGGAFEA88BBE4==?>;:=/9@9<C<<1(:3(3<9B00+58888>@3>7:>@CA?<B518
@1VJ
GCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCG
+
CCCFFDEDHHHHHGIJJJJIJJJJJJIIEGIJJFHGGGJJIDGHGHJJJJFJIIJIJGGIHIIDHGIJHFFDDDCDCDDDBDDADDCB@CDCDDD?>>CCB
@1VK
CCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACAAGACCG
+
CCCFFFFFHHHHHJJJJJIIJIIJJIJJGIIIIJJJIGIIIHIIJJJJJIIIJJIJJJJIIIJJJIGGHHHFFFFFEDDEDDDBDDDDDDDDDDDDDDDDB
@1VL
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@BCFFFFFHGHHHIJJJJJJIIJGIJJJIGGJHIIJIJJJJJJJJGGIBFGGHII>GIHIJJGHGDDHHGHHFCEFFFCDCD9=BD=CDDDCA@CDDDDD?
@1VM
CATTAATTTTGCCGCTGAGGGTGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGGAAACCCAGTGTTAGTGCCATCAGCTCTCGTGAGTG
+
CCCDDFFFHHFFFIGFGHIJJJIGIIJJJJJJIJGGGGHIGGEGIJGGGEIIIGIGGGGEHHJEHGIJJGIGHHDEFFFE;ACECCCCDDDDDDD?BCBAC
@1VN
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTC
+
@@@D;DDDHAHFDEHHAE<ACFDG@C;GFHIIIIDGHGH?CFB@A@)?AH;FHEHIGHFE==E?BCCAC@CBBCCCC@@CACCAC>?BCCCCCCCCCCCCC
@1VO
CCGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAATAGCTTCCAAGGCCCTGG
+
==?1+@D8<AD<:AA+2:CE<A2AAA??4?49?D3C;<D*:?*9?9D@D6?'.=8BC@7)8=)=@=)7;?>A;@AA)..6>@?((;;A;;>>A:(<9?9>?
@1VP
GTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTG
+
CBCFFFFFHHHHHJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJBGIHHHIHGJJJJJJJJJJJJDHIHHHHFFFDD@BBDEDDDDDDDEDDDDDDDDD
@1VQ
CTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTG
+
?@@DDDFFGHGHHJJIJGIIIIIJJJJFHIJIIIIJJIJCHHHJEHIJGGIIIIIGGIJGGIJJJJJIHGHFFFACEAEEEDDEDDDCDDDDADCCDEDFE
@1VR
CCTCTTCCAAGGCCATGAGTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTTCTTCTTGCTCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTTTT
+
@@@DFBBDHHBFDG=EGBECD<GHEEECBEHGIDEHHIIIIID@F?DABGGGGI=FHIGCG@>@CHEH@;AEEF@BDFC@C>ABBAB?BCBC:>CCCCCCC
@1VS
GTGCTCATGCTGCAGGTTGGTGAGCAGCTCGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGGTGGGATCCTTCAGGGCCTTCACAGCCACAAGCATCT
+
??<B;D?B4CD?<AA3<EBF:?3C9AC@3C8):0:0?D3B99??DBBCDBE==ADIIDDD?DD>8.;3;95,9A>5>AA?>88>>A>AA??2<<8(+8(+4
@1VT
TTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTT
+
CCCFFFFFHGGFHIJJJGJJJJJJJJIIJJJJJJJJJJJJJJJJIJJIJIIIIFGHIJJIIIJJJIIJJJJIFDDEEEEDDDCDDDDDDDDDDDD@CDDDD
@1VU
CTTCATGAAGAAATATATTATTACTCTTGAGGGCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTAT
+
=?+=A;DDFDFD?FE?FF?CD?:<E@D?<<F9+1)1??*?D<11*:<B@9??9DH:.'-.8.=./)=@3)>EH>).=7??;).))(6;?6?=;5(;;;B;
@1VV
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
@?@FDDDFDDHDDEFGFIHHIIEGC>EAHCCFFH?GHI?GHHIFFHEFGGEECCHGECHGGFHFEEFDBDD>CCAC@CDD8<A??:@@@CACACCACD<AC
@1VW
TTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGT
+
@B@DDFFFGHHHHJJJJJIIFFHHHIJEIIJIJHIJJJJJIIJJIDFHGIIFHIJJJJIJJJHEHHHHFFFFFDEEEEEACDDDDDDDDDCDDDDDCDDD9
@1VX
CTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAAGAGGATATGGAAGTTTGCTGGGGCCTTTTGCT
+
?@@;;3+AFF:3C@ECCFCHB?E<1@9*)1?:60?DE;DFDDF@F)@FF>F4/?=EFD;@?@AB>6>>;(,;@?B>ABB:>?B:34(4@B<BBBB@::4(4
@1VY
CTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
@@@FDBBDFFFBDBBHHIE@@BB8>CC@A8>@38@CDC>@A>CA?8?5BBA?A>:BCCCC@9@ACCC@@ACABDDDBCCDDA>3>A>AC@AD4@C4>A?
@1VZ
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
;??D=22AFFDCB<2<AE>@D3?342AE?C@AC>)?1*1?9BDDC:<D@BGAFF@D?D;=8))=FC>@FC7CE=BB?BDA@CC:;@A3@>>55;5@<?5<8
@1W0
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@C@DDDDFGHGHHJIJIJJJJJJJGGEGHGIGEGIJEHIIDGIGJGIJJDHHHIIHIGIJJJDGIHIHFHHGFFFDDEDDDD3;=@=CDDCDDCCBD?BDD
@1W1
CCTTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGG
+
CCCFFFFFHHHHHJJIIJIIGIJJICFHIJIJJJJJGIIJIJIGIIIJJIIIIE>EHFEFDDCCDDCCCCDDBCDDCDDDDCDDDDD@BDDDDDDCCDDCC
@1W2
ATTTATGACTCCACTGTTGTTTGCTTCATCTCTGGACTTATAAATGCTATTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTGAATTCTATGAAA
+
;??DBDBDDAFBFBBGFFHI@GEEI@@CH<FEEE>BGEEIGBCGH?DGEBF@?FBGEGH@6CCCHIIDE@CECHCECEAEHE;;7??>>;@C>DDE@DC
@1W3
CGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAGAGTTCC
+
@?@FF>D?FBDFHCFHBHDGIIIFCH?@GEBHCDHI>?FFFGF@AAFHGGHG=5@CGHHGCHFD>BC@;66((=;??;?B@C>>C@?CCCC@CCCA@::>>
@1W4
CTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATC
+
@@@DFFFFHHFHGJGGBGCIIGIJIEIJEGGHGHEHFGGIJIFHJGIGHJHED>FIGGIHIJHJ<FGHIGHJG=EEHFGFDEDCDDDDDFDDCDDDDDDC
@1W5
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
?@1BDDEFFHDHHCGEIJ@EFHGIGIGDFEGG?BEEEGGC<GBF=FHIJIJBAGIGEGEGGCECEHBBDEEEBCCACDCCCCEDED@BDCCDDCDCACCDC
@1W6
CTGGGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTC
+
CCCFFF@DCDFHFGIIJIIIIIIJJJJIJJJJJJEIIIIJGIIJJIGJHGIJJJJIIGHIIJIGHHGIIGGEFHHHHFFEFFDDEEECEDCDDDDEEDDDD
@1W7
TGTTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTG
+
@@+ADDDEHHHHGJGIIJJJJJEHHIJJJJJGIIIIJJJJJJJJJJDHGFGICGIHIJJJJJJJJGIJJJJHFAEECCCCDDACCCDDDDCDDDCDDDDDD
@1W8
CTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGGCTTCAAGCTGTCTCTGTAGAGCACACTTTTCT
+
@<@DDDDADFFFD:EH@FHGIHHIGIIIII@HCB9CE:?FHBECD9DEGGG3DGGAGGIICBF@<8=;(;CGG=C)77=)==AE=?@@;7;BBCAC:ACC>
@1W9
AGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATC
+
@<=DDDAAHDHHDGGBHGAAEF@;BCFGGEHIGCBGGBBHG?DFAGGF@FHGB4@A==AEA>BBC;;C>ACAA?5>>;>@CA?<<?9>>ADC>>(9AAA
@1WA
GCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATC
+
CCCFFFFFHGHHHJJJJIJJJJJJJJJIJJJJIJJJJHHJJJGJJJJIJIJJJIJIJJJJJJIJIJJGHHHFF@CDDDDBDDDDDDEDDDDCDDDDD<CDD
@1WB
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
??1BDDDDHFB??EDEC<FGGCHADH9<EEGGGGGHICF;)9???BGA78BBAC8;C;;@=AEA?B>@?@2.;?B>A;?BB'2(>ACCB?A?:@@@@><?>
@1WC
CTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGG
+
CCCFFFFFHHHHHJIJJJJIEHIIJJIIIIIJJIJJJJJIJJIJJJJIHGIIIIJJJJJJJJJJJIIJJJJJJJJIHHHGFDDFEFDEEDDDDDDDDDDDD
@1WD
GTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCT
+
:?+=BDDDD=1DCG==AFFFB8DDFFDG<9D?DDDB*/?9C9;C8@;@C=CDEEE@;6,7,56>@9>ABAA?<3<(3<:>AB<4(+349<9<@8(8<38?A
@1WE
GTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATG
+
@C@FFFFFGHHHGIJJGIJGIJIJJIIGIIJIGHJJJJIIIIJJJDHHJIIIGGIJGGHIHGCFEGGHEHIGGHHHHGFHEFBDEFEEEEEEBDDDEDDD
@1WF
CCTCAAGTCTACACATCATTCATTCATCACGCTTCCTTCCTTAAAGGAGACAGTGTACTATTGAACCAACAGGATATCTTTTTTATTATTTGCATGAGTT
+
@@@DDEFDHHHFHEIHIIJIJIJJGIIIFJJJIJIHIJHGGGGIJJIIGIGHIJJHGGDHHJHFGHIJIIGIIGFHHGHFFFFDBCDDDCDDDDDDCA;@
@1WG
CTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTC
+
CCCFFDEDDFHFFHIGHGIJFHHGBGHHGDFHGD?9DGGGBF00BFGHIIIJIEHGHIGII74=FEEEIEHCEEHGFGDDEFDFFEEC@?C>AB?C?CDC
@1WH
AGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTC
+
@CBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJIJJJJJIJJJIJJJJJJJJHHJJIJIHHHHHHHFFFEDFEDEA
@1WI
AGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTC
+
@@7BDBDFHHHHHBEHIGIIHHGIEGHIII>HHIGGIGIIGIIIGIIHIIIIGIFCEEEHFFFDFFDEEEECEA@DDCDDDDCCDDCBBBBDDDDDD::AC
@1WJ
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
CC@FFFFFHHHHHJJJJJJJJJJIJJJJJJJJJIHHIIJJJJJJJIIJHHIJJJJJJJJJJJJJJJJJJJHIHHFFDCEEEDEDDDDDDDDDDDCDDDDDD
@1WK
GCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGC
+
CCCFFFFFHFHHGJJIJIIIIIBHJIIJJIEHGIIIIJGIFJJJJFHIJJIJIIJJJJJJHIJJJJIJGIJJEHHHHHHFFFFFFDDEDD,;B;CCDCDD
@1WL
GGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGGCTTTGCTGATGTCCGCAAACACCGGCCTTTTG
+
?<8D4=AB?:F<<A:<<CB8@?C?8D@1B*9BBFBBFFF@=88=C@A@FF==CF3@EA>E?:A??7@'5;?@@>A@;>;-:5<88?5??B?<9<0<AA>3
@1WM
CTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACAT
+
CCCFAFFFHHHHHJJJJIJJJJJJJJIJJJJJJJJJIJIJJJJJJJJJJGIJJJIJJJIJJJJIIJJIJJJJJJJHHHHHHFFFFFDEEEEEE@CDEEDDD
@1WN
GTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAA
+
BC@DFFFFGGHFHIIJIJJJJIIJJJHIIJIIIGJJJIJIEIIJJIJJJJHIIIJJHHJGIJJJIJJJIIIJJJGHIJJIHHHHFFFDFFFEEEEEDDD
@1WO
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
???D?82)ABDC<+C<3CC:A<FF>:C9?:9)99CD3DDADEBD>90?@DD>@=B<<CCCC;@@D1=A@D;7;;AAA:>=>;5>AAA?:5>:>>AA:5:AA
@1WP
TGTAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
1114==BD=CD?B3@A@FG<<?CDFIEGFFEFF3DGGF<GGE@FAFDFIIIEC=@D>D=4CEA;@C>E;A;@DD>@@7@CBBB,';=??0<:@>>>@AB
@1WQ
GAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTC
+
??;;D4ADDDD>3C8C?CED<CE:?::*?B?D?DDDEI<DEECC?@@AD@>=@>6(;>:=???;8;58?>>>8A?>A:+:B>(:>AA>8>>>>>09>>9>>
@1WR
GCCTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTC
+
8=:=DBDDH?FC?FGIIICFEGA@FHIIIHIGHCBFDGIHI<GHDGIIGHGGE@DCFGFGFCFCHGI@BFHC@@CGGCE=C>E>EDD?DEBCCDDCCCCCC
@1WS
AGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAA
+
CCCFFFFFHHHHHHIHIJJJJJJJJJIJJJJJJJJJJGIJJJJGHIJJJBEFEEEEEDDDDDDDDDDDDDDDDDEEDDDDDDDDDDDDEDDDDDCDDDDD
@1WT
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
CCCFFFFDFFHGHIAFGFEHIGIIIICHIIEGGIJJJJGEIHAG>GIFEGGIGAHIJJH4?CEEEDDCDDDCDCB@C@@C5@ADCDDDDDDD3@ADEDCD
@1WU
GTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGG
+
;?1BDA1BFBFFF;;CFBFC@DA??GGFFFFADGFFECF>>?F<@DFF898=B<:8=@;A;@EA?>AE>BBDDBA:>;>>AB?A:55;@>BB>;;>8/8<0
@1WV
GTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCT
+
CCCFFFFFHHHHHJJJFHGHGIAFIIGHHJJJBDHIIIIJJIJJJJJJIIHE?BDFFFFEDEECEDDDDDDCCCDDDDBBDDDDDDBDDBDDDDDDBBDDB
@1WW
CCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGG
+
@@?BDDDDHGAFDBGDDHCHHHCCCHBBHIHHIJIIJJFHIGIHIIJJGIGIIJIIBHFDEFFDECEEDDCDCCDDCDDADCDCA@CABDDCDDDDCDCCD
@1WX
CACATCAAGGTTGGAATGAGCTGGATAAGGCTGATGACCAAGAGTTAAAATCTCCCAAATCAGAATTCCAAAAGACCATACATCAGATTGAGTAGTGA
+
@@@DDDDBB=:?C::C<<F<@D9E+AF+A3*:C;DF4C*9B??D?BBFFFIFI??FCE9C3=FEGICBEIE;=7(=;>B;;@BA>BA;@@@5;>A5;>
@1WY
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
@@<BDD?DHBFBAE3CE?BHEHCADFF?CFG:CFH?DDGDD?7?DBDFGHIIIGIDA;=@=ACA9?BECAC?CCB>CCCCCBBBB;9:>CC@C::>@@@CC
@1WZ
GTTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJIJJGIICFHHJIJIIJIHHHHHHFFDDACD@CCCDDDDDDDDDDDD
@1X0
GGCCTGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTC
+
CCCFFFFDHGHHHJJJJJHHFHHGHGHIGFHGIGIJIJGIJIIJJJIJJJJEGHIIDHJIJIIDHHFFDDDACEBAA?BDDDDDDDBDDCDDBBBDDDDEE
@1X1
CTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCTTTATCTTTTTCATTTTCCATATATTCACGAACCTGATCCACATGAGTTGAATAAACC
+
??;DADBDBDHDFIIHIHJJHIIIGHIIJJIIIJIJIGEGEHIJIJJIIGEGEGIIIIJIJJJIJGBFAEFHDGEHEHEFFFFFDCDEECCDDEDDCD
@1X2
CACCAGGCTTATTGAAGCCACCTCGCTCTCCAGCGCTGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCT
+
@C8DDDDFHHHHHJJJJJJJJJJJJJJJJJJJGIIJJJJJJJJJJJJJJIJIHHHFFFFEEDDBDDDDDDDDCCDDDDDCDDCDDCDDBDBDDDDDDDDDB
@1X3
CATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTC
+
;<<DB?D>=BCD<4,:2+AC<A3?AEE+AA<?D>DBAAFC99B?BAGBBDG>D@DECBFEGI:F>>F344@@C;C::.7774C=E@AAEBD>>3?@>;6;6
@1X4
CCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
C@CFFFFFHHHHHJJJIIJJJJJJIJIJEGGIGIJHJIJJJJJJJIJEIFEIIJIIJJIJF=A>CEDDDDDDCFDDDDCDDDCDBBBDDDDDDDCDDDDD
@1X5
CCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJJIJIJJJJJJJIJJJJJJIJJIJHHHHHFFFDDDEEDDD
@1X6
GGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGG
+
@C@FDDEFHFDHDIHIGGIIJEHDHIIEGHGGHGIHIIG0DBGIJ:ADFFFCE@CDBDBDDDDDDDDDDCDDDDDDDCCDCDDDEDDDDD@CDCDDDACC@
@1X7
CTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGT
+
CCCFFFFFHHHHGJJIGJJJIJJIJJJJBHIJJJJJJJJHIIJIJJJIJJJJGGGIIJJJJIJGIIJIIIJJJHEHHGFFFDFEEEEEDEEEDDEEDDD
@1X8
AAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTG
+
@@@DDBD:AF<CFFCF@FE8@CFEH@<BB9?@F:?FAGGGGI3?60@6*?@@';B(==?ACAE?BD;;??@B==B@CC>:>A?B(8034@CC>>C>C@CCC
@1X9
GTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGT
+
?=?D=?DD4D82?3CE;:FFDE0@;:@DEDECE>@:CDDD6A<CCCDDDD;;AA;@;5>5;5,;;;;>:>AA??9<9&0;+:>AA3>>>>A::>:A<A>A4
@1XA
CCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTC
+
CCCDFDFFHHHHHDEBFDEHDDCCEBEBEEE@H?99??EFGEHCHGIIG<FFH@DHBFGCBFHIHI>F@C@@@A@AGHE7?=C>=>;@77BADD6=@>>=?
@1XB
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGAGGGCTGGGCGGTGT
+
???DD+2AA,A22<<AEEBAEE9:?3??B+?99:E1:13:C<?D?@D49?DBD?8;;/*9CBCB5=44@7A;A73)77?A;;;6@((.5'3;,28<;;)0)
@1XC
GCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGG
+
@@BFFDDFHHHHHAEGIHIJJJIICFHIJIJJJJJJJJJIJJJJJJFGGIIJJJJJJHHHHHHHFFFDEEEEDDFDEEEDDDDDDDDDDDDDEEDDDDDDD
@1XD
CTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTG
+
CCCFFFFFHFHHHGHEGIGHIIJJIJGIGIJJJIJJJGIIIJIIHGEGFDDGHHIHIIJGIIIJGEEFGFEFFFFDDDBBDDBCCDDEEED@CCDDCCCC
@1XE
GTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGG
+
BCCDFFFFGHHGGIJFHIJJJJJJJJJJJJJJJJJJJHIJJJIJDFFHIIIIIJJJIJJJJCHHJGJJH;CDFFFFDEED;ACDDDDCDDDDCDDDDDDDD
@1XF
CCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTG
+
@@?DFFFFHHHHHJJIJJJIJJIGIIICFGIJGHHIJIIJIJIIJJIII4BGGIIGGIIIICHIJIIGEIGGIJEHGIGHHHHHHHFFFFFFFEECCEEEC
@1XG
CCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCCTGTTCTGATTTAAGTAC
+
CC@FFDFFHHHHHIGHJJIJDD6<BDDDDDDDDDDDDCDCDDBCCDDCDCCDAACC@A@DDDBDDDDCC@@ACADCDDDDCCCCDCDDCCCDDDDCDDAD@
@1XH
GTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCC
+
CCCFFFDFHHHDHGIGHIJJIHEHIJJEFHGGIIIGEHGHIGIIGIIJIEGHCHD<@EHIJJGECCEDEDFECECCCCCCBCCC>CCDDDBDDDC@CCB@B
@1XI
TGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGG
+
@@<DD;?A??FDAHEHBGGHAHHDCGHGHIBEH@B?FGEGGGDD@BHGGHE>FDHIAF@@EHB(?B>CD?@CCC;C33;',8:>>>C>89ACCC@A4:599
@1XJ
GTGGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGAAGTGCAGGGGATGGAGACAGGGCGGCACTAGGTTTCATGCTCATATCCGGTCCCGGCAATGC
+
@@@B?ADDFAADC@BEHC9CHGHGCFEHCFEHHIHGDFE?DGCGHIB4'@ED6?EHEDE=BBBBBCCAAC>ACD@CCCCCCCDCDBB>@BBB@BBBCCC
@1XK
GCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTC
+
CCCFFFFFHHGHHEHIJIJJIIJIJIIIIJJJJJJJIJJJJJJJJJJJHFGEFEEEDEEDDDDDEED@CDDDCDDDEDD<BDBDDDDBDDEEEDDDDDDDD
@1XL
CTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGC
+
@@;DBDDDHFFFHDHGGGB@CEBHEHFE>FEFGCCHGEIIIGDFGHGGI@FGBHIIEADCDF=CCCCGB-9>@,;>>;:>C:55?B>@BBBCCCBB:>CCA
@1XM
GGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTC
+
@@@DDFFFHFBHHIIBGHEHHEHDEGHBHICGHIHIGIGIGEHJFHDCGGHJJJIJIHIIGG@CF@EDGHFHHHHFFDFFFDD@DD;>;AC@C:@@@:@CC
@1XN
TGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTG
+
@CCFFFEFHHFGFIIHHHJJJJIFGIJHJJIIGIFIJJJJJJJJIJIJJJJJHHGHHFFFFFFFEEEEEDDDDDEDDDDDDDDDDDDEDDDDDDCDDDBDD
@1XO
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
@CCDB?ADFHHFFHIIIGGIECEECFHIIIEEHGIGF@GDHF@DH<BFH?DAHBEHDHHF8=BFHH.;A:=?ECHFDDFEEBDE;@E@ABA?C@=@?BD5>
@1XP
GGCAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGG
+
:?1=ABDDAFFF:A3AB<CDEEHFHI<B+<A;F9@FFAFBGD@F?C?DFDF<9BFG?DBF83?FFEIGGIIIEECDD=7==@=CEEAEC;;@BD@BCFCBC
@1XQ
CCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGG
+
@@?DFFBDHGGFHIIEFHIEADCGGEHIFIDHDHDGGG9FH@DGGHGIEHGHHDHHJGC=DEG>EHFGFF>B@DACDBB?@3>@CC(:A@CDDC?A@@CA:
@1XR
CCTGGAGCAGGTGCATCACATGGTCCTCTGTCATGTTGCCATACTTGGTGGCATTCTGCATGGGCCCCTGGGGCAGGGCTCCCATGGGCAGCGCCTGCATC
+
@@@D=DD>A?;ADGGBA+CFE?;FFHIIIIIFDGIIGGFGGGGHIIGCBDGDBGHIGEHEGBBGFCGGIIA;4?D?<ABBB@BCC?:9?C6@B@@@<?CCC
@1XS
CTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATT
+
CCCFFFFFHHHHHJJJJJJJJJHJJJJJJJJJJJJJJGHIJJJIJJIIJJJJJJJJJJJIHHIJIIHHHHHHHHFFFFFFFEEEE@CCCDDBDDDDDCFDF
@1XT
CACGAACCTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTG
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJHHHHHHFFFFFFFEEEEEEDDEEEEEDDEDDEDEDEDDDDDFFD
@1XU
ATTTGAGTTTTCTACATTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGAT
+
B@BFFDFDHHHHGJJJJJIJIIIJIJGHIIJJJJIJJJFIIJJJJJJJJJGHIIJIJIIJJJHHIIJJJJIJGHIGIGHIIIGHIEIJJEEHHHHDFFFF
@1XV
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
?@:BDDFFHHHHHIJJJJJJJJIJJGIJHHIIGIIJJJGIIHIJJJJIIIJJJJJJJJJIHHFFFACEEDDEDDDDDDDDDDDCDCDDDDDDDBBDDDDD
@1XW
CTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CC@FFFFFHHHHHJJJJJJJJJJJJJIJJEGHHIJJIJIIJJJGHGIJJJIIJJJJJJIJJJIJJJJJIGHFBDDEEEEEDDDDDDDDD?CDDCDDD?CBD
@1XX
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
@@@DFBDAFHFHHJGEGGDHIJIIIGGIBDGGIIEHDGIJJJJIDGGG@BEHCHGHCHEEHGGIIIHHGHEFFFFDDCDDDBBBA@D=BB9@CC@CCDDC
@1XY
GACAAGCCGAAATCCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCTGCCAAGTCCCGATGAACGAGCTTCATCTCGGCCAGATACTG
+
??1ABDADHHFDDD?CGGHIGGIGGFHGIIBBHCADEHHIG@BGAHIGGGD7CHCCC;CEDEDAC=CCCCBBBBCCC@B=<@:A>>3:CBBB9>B@CCC@C
@1XZ
TTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTG
+
@?@DDB4DFFABBFGDEFIF;E11@EC31C1?:CBFG<GEC<GFIFEE0?<FEIFEFGE@4=@7??8B=@ABA@?:;3?:>;@ABB@BBB3>ABBB<:@@A
@1Y0
CTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTG
+
CCCFFFFFHHHFHIIGIHGIEHIJGHEGIIJJCGIIJJJJFIGIJEBBGIJJJIIJJJJJJJCGGJJJJIJJEHEHHHFFFFFFECEEEEDDC@DBDDDCC
@1Y1
GGTACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAAT
+
?@1ABADDHHHFHGIIIGIEIIIIIIEHEHIGIIIIIIIIIIIIIGIIGIII@GHHFGHIIGIIHEFEEBCCCCCB5;?CC@CCDCDDDCCCCCCCCCCBC
@1Y2
GATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACT
+
=@+ADDDDHD?FAEHIGGGEH>BGGCGEB:FDB@<C?EHHHIICDHEGEHICDEH>F9D>BFHEEHCFHGIIIGIIF=CG@;C;@@GAGFFACEHEEEB@D
@1Y3
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@@@DDDDABFFFHEEGIIEEHGHAHGG?GHIIIIIIBG1?DHGHD?FEH@GHIFCGA@@EGHH>CEE@DBCE@ACDCCCDCCD>AC:A>ACCCDCC>>:>C
@1Y4
CCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCAT
+
CCCFFFFFHFHHHEHHEEHIJIJJIIJJJIJIJGGHIJIJJJJJJIIGGHIJGHIFGIHHFHIIIJJGEEHFFDDBDCDCACDDB@BDDDDDDDDDDCDDD
@1Y5
TGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTC
+
@@@DFBDDHADDHIGIIIIIB<CCHGGBEDHIGBFEGFFHIGGIG';@FG@DHIHHFHHFCD=A@AC<;58=@CDD>C@CCCCDDDB@?>ADDDBDD9A
@1Y6
GTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTG
+
@:8BDDD8??DFHC?BGH@<<:FCC?F<CFDGGC?:DF?D?GH;B9BGH*?DB;BFB=BC8CCG)===7==DD>?EA=;BDEEECCCC:;55=?(388@CC
@1Y7
CTTATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCC
+
?@7=?ADBAFDA)C=>C<E??2<<A<8)):?9*B<??9;B9@?B?=B<B==FC;EFBEEAE==>;7?@AC@B,9;@@35>>3299<8:3:A>@ABBAB@12
@1Y8
TAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGA
+
@CCFDFFFHFHHHGJIGHIIIIIJJJJIGIHIIJJJJGJIJIJIIJJHHHHHFFFFDCCDDDDDBDBB>BBDDDDDDDDDDDDDDDDBBDDBDDDEEECB
@1Y9
GCCGGATAAGGCTGATGACCAAGAGTTAAAATCTCCCAAATCAGAATTCCAAAAGACCATACATCAGATTGAGTAGTGAAGATTCCATCCATCAAACTTTC
+
=?+=DDFADDFDHDBEHIGIGGGGHEGHGIIIIGIGEBGGHII>GIGGIIIIGH>FHACFEHGH@C@;@CEHHHE>DDDDD>@A@DAECA:A@CCCCDCCC
@1YA
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
=;+4ADDDH?AHFGICDGIGAEC9AC91?CD911:B8:?<GDB3BEH3@;=F@)@=@D=@ACAA?==?B>9>>AC(;>;;;5(5((((>@C:>AC99:@44
@1YB
GTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGT
+
?=?D:BDBADFFFFIIBF?C?IB:FBHHHCIIIEFHFEGEFCFFCDBGFDD<9DF@F:DDFE898BFDGDG>)@FGICFIIIE@EFFFFA?A@BD?C>;@>
@1YC
ATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATC
+
@B1BDEFFHHHHHJIJJJIIGIGIIGGIIIJJJJJJJJIIJJJIIFHIJJIJHEEHFFFFFFEEECCDDDDDDDDDDEEDDDDDDEDDDD<>DDDCDDDED
@1YD
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGG
+
CCCFFFFFHHHHHJJFHJIJHIJFHIIIIIIIIJJIJJIJJIJJJIIJIJJHGJJJJIGIGHDHHGFFFBCCCCEEDCCCCAC:ACDDDDCDACDDDDDDD
@1YE
CTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATC
+
@@@@DDDBFC:ABBEA:AF@EEGIIIIIIG<BECEAD1?<9??CFCF<BCG3?F4BGEGFBD4?=8CB8BCE7.=F9@G:..=7???;=9@?B/1;;>>@3
@1YF
CTCATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGT
+
1=+4=BDBC:ADFBEEGIICHGHHEG@E9CFCABHGH@:BD@FGGIICCGGIAFHIEICGEHEEG:C))>==?EHCEF@B9@=BCC@@CCCCC;@@,<;=?
@1YG
ACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGG
+
@@@DDFDAFDHDHIIIIFHIGGEGGGAFHHIHBHCHBE>FGC@FIGCFII;3?9B?0BBF=FGEH:=FGCCGGEEAAA;>EDFF>DCCEEC>6,5@;A;AC
@1YH
TGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGG
+
@<@DDDFFGDBFDEEB@EHCAFCEHDAHG@FDDE?FGICDHH@B???DHHGGBCHGHG>FA@CFIGDH@C@=C>ECHHC>C;B@D;;AACC@DCCCBACCC
@1YI
GCTTTTTCCAGGGGCACAATGGGGACCAGTTGAGCAACTGGTGGTGGAGGCTGAGGCGGAAGGCCTGGAGGACCCTCCTGGCTGACACCAACAGCCTT
+
@@@DDDDDD<<D:?)<<:+<?A8<11??B?:??FGIIEFC@09B(-78=CCCEC=;E?<>8B?9?:??B<?812?<BB<4(83283+4<<8@BB8?<>
@1YJ
AGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTG
+
@@<DFFDFHHFHHJAEGIHIIJJJJEHHGGHIJJJJJJJJJJJJJJJHIJJJJJJIJJEHHGHHFFFDDEDEDDDEDEEEDDDDDDDDDEDDDEEDDDDDD
@1YK
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
???D1ADD8CDDAA:2AE?EED>DDCDDAD><D>DBBBADIACEIIACAE<;@@@CDDA>.?C>@DDDEDAA>@A;A>?8;;=AA>AAAAA>:8>:>>AA
@1YL
GTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTG
+
@@@DDBDDFFHDA:EGIIHCBGE?F?CEG?HE?DBDHGGDHIE94BB@BDGH>/?DGGIIEGGFACADGGBEEEBEDCCECCCBBBCCCC>CCBBBBBBBB
@1YM
CGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATCATCGAGACTGCCGGCGAAACCGTC
+
CCCFFFFFHHHHHJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJIJHFFFEDDD
@1YN
GACCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGT
+
:;14ADDDHHBDDH@CFIGHFGIGIFGFDGGGHIJJIJJIIGGHGGEEHIJIFHHCHGFFFFEDCCCEEDDDDCCDDDDDCDDCD>CDDDD>BCCCCCC@>
@1YO
ATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATG
+
CC@FFFADHHHHHGIIIJJJFHIJIIJIJIJGIJJGIIIHIJ<FHIIJIIIJJIJGHEFDA@BDD@CCCDD8?;ADDDD@DCDDCDDCDDDDDDDDEDCDD
@1YP
CAACATCATAATGGCTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAAT
+
+=144=3BDDD4CEEE@E++:AAE<DE4C+9*?4CE?B*:CDE*9?<:?9DB>)?(2BCC;B)/=)=))/7).77=;)=?>?@31);;AA;;;(5>;AAA>
@1YQ
AAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGGATTT
+
@<<DDDADHH?CBFGHGGHICGHBBHDGCGHIDDHFHGDEEDACDFIEHIICD?DABHIAB@FEAG@B<CGGAFHDDEHHECHHFFB;=BCA>@CC'5;5:
@1YR
GTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCC
+
=@+=DDDA=CDHHIIBEGGIECDHHIIFIEGCHGEC@GGIIIIEHIGGIIIGIIGGIIIIIIGA=CEBDEBCCCCACCAABACCACCACCBCCCCCCCBBB
@1YS
GTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGT
+
BBBDFFFFHHHHHJJJJJJJJJJJIIJJJJJJJIJJJJJIJJJJJJIIJJJJJJJIIJJJIJJJJJJHIJIJJJJJJJJIIJJJJHHHHHFEFFFFEDEEA
@1YT
GTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGG
+
CB@FFFFFHHHHHJGHIJJJJJJJJJJIJJJJJJJJJJJJJIJJJJJJJJJJJJJIIJJFHIIJJGIHHHHFFFFFEDDDDDDDDDDDDDDDDDDDDDDD
@1YU
CTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
CC@FFFFFHHHHHJJJJGHJJJJJIJJJIIHIJJJJJJJJJJDGIJJJHJJJJJJIJJIJJHHHHHHHFFFFEEEEEEDDDDDDDDDCCDCDDDDDD>AA
@1YV
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
@@+=DDFFHHHGFIGGHIIJIGFHIGHGIJIIFGHGGHICFFFHGGHIIJ@FHIGH=ABBDDDDDBBDDDDDDD@DDBDDCEEDDDDDCDDDDDAAACC
@1YW
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGC
+
??=DDBBB?BDH?CCFACEGBCHGAB?BEDGGHIIGICF>DFFHCD;FE@FIED>@CHDDB49ABACCCA>=B;<?>:A@CACC>CC>?A599BBCCCC:C
@1YX
CGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCTCAGACATGTCTCACAGCGAGAG
+
B@1ADDFFHHHHHJJJJJJJJJJJJGJJDGHIIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJHHHHFFEFFEEEEEEDEDEDEDDDDDDDDD
@1YY
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@@<DABDEHDDHHIIGEGCGHICADDGHIDGGIGGEGIIIIIIIIIIGGGIEFCEFFEHDFFFFECCCDCDDCCDDDDCDDDEDCCDDDDDDBBDDDCDDD
@1YZ
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
@@<DDDDFHHHHHIJJJJJJJJJJIJHJIJHIIJJJJIJJJIIJJJJIJJJJJHIJJJJJIJFIJJJIIIJ@EFFFFFEDEEEEDEEEDDDDCDDDDCDDB
@1Z0
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
??8ADADADFDAHGIIIIIIIIII@DHHDHI?DGEEEHGBGIIIIGBE?FHGGGBDGIIG@FHGEGE5<?DC>CECACCCDDCDD<@@C@C@9?B>@ABB
@1Z1
CCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCC
+
BC?DFFFFGHHHHJJJJJJIJJJIJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIGEHHHHFFFFFEEEEEEDEDEDDDDDDDDDDDDDD
@1Z2
CCATAAACACCCATGCTACTGGGGAGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
?;=DDDDBDDDDDEEIB43C::<@+111?990B??@D;?*??*BB<8)>.3((--5-?7.7..@7?AABB;(>(-(5;>;:(:;,(:,9?A323>8++4>
@1Z3
GTCAGAAGTTGGTGGGAGAAAGGGAAGTGCAGGGGATGGAGACAGGGCGGCACTAGGTTTCATGCTCATATCCGGTCCCGGCAATGCAGATGCTGTTTCGG
+
?@1BDDDDFFFF=F=G:EEEFFIE=FEFDFFDCFF?DGI<B@BFEBF?B>:?BBBAB:>AAADBBBBBBBDBEBBBBBB@B9>BBBBBBABBBABBBBBBB
@1Z4
GGGGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
=@1ADDDDFFHDAG:CEFHIEHIGIIJJJIIJJIDDGDHGGDDDGE@DG>F@?C=CCHGECDEGGACA>EBBABB9@AAAC@C4>>4>@CDDCCD(:?B
@1Z5
TGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCC
+
<<?DBDDA?FHHA>B@G9E4EHDC<4AC<BDAFG4CGEGHCC4CD4<BBF?BD>F@>G<B?9BC3BB1..)844==C;));7=A>;?BEB@B;>A:A<;C>
@1Z6
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCG
+
@B8DDDFFHHHGHIJJJJFHIJJJHIJJJJJIJJJIIJJHJJJGGGHJJFHIIHGHEGIIJJCHEHIHHFHHHFFDFFDCEDDDD@BBDDDCCDDDDDDD
@1Z7
CTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTA
+
CCCFFFFFFHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJIGHJJJGIJHJJJJJJJJJHHHHHHFFFFFFFEDDDDDDDDDDDEEDDDDDDDDDDDDDDD
@1Z8
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
=?@=AD=BFFF<?GID>E@AFA><<FHCCFB)?DHIIIC;FE6BBFD8C>FAGHICDDDHGHHFEEE>;;6?A@B>;;>@CBBB<8?CCCA>B@::>CCCC
@1Z9
GCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCT
+
?<@DADBDCFD?BEB<A@@EHBHHB>BCABDGGD@GF@BBDDB>CCHGGAC>;?EFDE@CAAEECCCCACCBB@?2:>?<A9??A:@>?>C<?A::595>B
@1ZA
GCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGG
+
C@@FFFFFHGHHHJJJJIIJIIIJJJJIIJJIJHIIJJJIIIDIHIIIIGIJ@BEFGAHIGGIIJJJDHAGDHH=EEFFEBDFECCCEACCDCCDA@BDDD
@1ZB
CAGGCGTGTGCTGCTGGACATGACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGA
+
C@CFFFDDFHHHHIIIGIIGHGHIJIIIJIEHJJJIGIIHDDDDDDDDDDBDDDDDCCDBDDDDDDDECCCCDDCDDDCDDDDDDCDDCDDDCCCDB9
@1ZC
GCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGT
+
??+4ADDABC3CAC1<<AFFAFB<?FFDA+2::*?<9)9C3?9?0?9:09B9DEDB@<*<(B;AC=;)@=C;A=((.??A@;?6.66;@(-55>55>5;A5
@1ZD
AGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTG
+
<@@DDDDDHHADHIGIIHIIGEHIIIGHBH>HIGIFIJJIEE9CGGCBDFDFDAD@FGHIGCE@ED==@FHIIJJJG@@CECACEFBFEEFEDE@AEACDD
@1ZE
GTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCT
+
@@@BDDDDF:AD>HIIAFFHEH@EHGEGEGDGD0?FEHEHGGIEGEH@E;AE??BEED:@C>CCCB@BBBBCCCCCC3<BB>BBBBBBBBBB5<>9B<???
@1ZF
TTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGC
+
CCCFFFDFGHHHGIIJJJIGHIJJJHHIGIJJJJJIJIIJIIIJJIJJIJJJIJGIIIIJJJIJJJJJIJJJJIJJJJIHHHHFHFFCEFFEEEEEDDDDD
@1ZG
ATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGG
+
CCBFFFDFGHHHHIIIJIIJJHGIGIIJJGGIJIIIJJJJJJJGIGGIJJIJJJGIHGIIIHHHGHHFFFFFDFEEEEECCDBBCCDDBDDBBDDDDCDDC
@1ZH
CTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACC
+
CCCFFFFFHHHHHJJJJIIIIIIJJJJIJJJJIJIGIJIIIJHJJIIIJIJJJIJJJHHBDFFEDEEEDDCDDDDDDDDDEDDDDDBDDACDDDDDEDDDD
@1ZI
TGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGAGGGCAGTTGGAGTAGTATAACCAGTGGG
+
BBCDDFFFHHHHHJJHJJHIJHHJJIJJJJJJJJJJHJJJJJJJJJJIJJJJJJIJIJJJJJIIJJJJHHHHFFDDDDDDDDDDCDDEFFEFDDDDCDDD
@1ZJ
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
?@=D;+ABBDFB<CFAA?C:)3@<?A?CF<FGI@FD?B??)9?09D?:(.77FC>F3;DE<A>).7?BBDD9;=?3>;5??2=5:A:A@9><4@>(4@?B9
@1ZK
ATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACAT
+
CCCFFFFDDHFHHIJJJIJGIJIJJJIFCGHIHGJJIJCGGIJJJJJIJJGHIJJJIIJJIIIJIGIIIJIJJIEEFEB@DEE@CDEEEDDDDDDDEEDDD
@1ZL
TGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@??DB;BBDFHFHIIG=@:@FH8?BD9?BBGGGGGGH?GH;BFEECFGCECEHHHHH<AD@CBDCCC>CADCCCCC;>>CCCCDCCCCC::@<>?@B<>@
@1ZM
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJIJJJJJJIJJJGIJJJJJJJJJJJJJJJJIJJJJJHHHFFEEEEEEEDDDDDDDDDDCDDDDDDD8
@1ZN
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCC
+
CCCFFFFFGHDHHJJJJJJGJJJJJJJJIJJJJIJJHIGIIHHIIIJJJJJJJGHIJGHIJ;@GHEHHHFFFBDEEEEDDDDDDDDDDDDDDDDBBDDDDD
@1ZO
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTG
+
@@CFFFDFFHGHHIIJHHGJIIIJJJJGGGGIJIIIJIEGIIFHGHIJJJIIJIGHHIGIIJIJJJFIGIJFFGHCECDFFCDC@?CCDCDDDBDDDCCCD
@1ZP
CTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTGTTCT
+
@@@FFFFFHHDHFGEGGGIJJE4:BFFDFAGCBEBGGIIGEGGIII9?DHIEEECHIGIJFIIHH:==CBEDB7@ACC>CCCCCDDDC>CDCA9??BBDCD
@1ZQ
CCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCC
+
=?@D:ABBDDDFFGIIEHG=EFG@<FGGCHIBHC@FBGFHGDD<@F@?@D>9D?@F<4B??CFB>=>CHFD8@@EGGGC@C>?=ACA;@BEECCC;;;;>A
@1ZR
CCCGAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCCCCCGCCATG
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJIJJJJJIJJIIJJJJJJJGHHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCDDDDDDDDDDDDD
@1ZS
GTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTT
+
C@@FFFFFHHHHHJJJIJJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJIJJIJJJJJJIJIJIJJIIIFGIIGIJJJHHHHHHHFFFFFFFE
@1ZT
CCCGCCATGAGCTCCAGCAGGATGAACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGC
+
?@<DDDD?<DBDHGGGHHGDHAHGHIIIIGG67@AABGDEIGHIEE;?A>BDACCECCCCCB@B6>CC:ADDCCC:?80?BCCCCCCACCCCCDECDCAA@
@1ZU
CCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCC
+
8;?DDFFFHHHDHIGEGGG@FGIIGHIIG@GCHHDGFFB<BHEHBDHGIIBFHEGICH;CEHGCECHHECDFE=;;;ACA(5>>C@CCDCCACCACCCC38
@1ZV
GGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGC
+
CCCFFFFFHHHHHJJJIJJJJIIIJJHHIJJJJJJIFHIIJJJ@FHJHJJJIJJDHIJGHHFFFDEEEEDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDD
@1ZW
GTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGG
+
@@@FDDB;2=CDHGI@FHAEHIIIIHGGG:?C?FEGIIBHIFDFHEGIGEIHFCHIIDH@DAHHIGGEHCGIHDFHCECFF;=BCB@;;@C>CCC@??B?>
@1ZX
CGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTG
+
?@@D?DDDHFDDHGHGIFHIDBH<?9EDGEHIGHIIIEIIIIGHIIGIIICCAEFHDHEHIAE@GHGG@ECEBABED@BCCCBCCCCCCCBABBBCCCCCC
@1ZY
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACT
+
@C@FDADDFFFFHGFHGDHH<GGIGIJIGBFC?GFHIGCGHGGEA@@GGGGHA?CHHFFFDDD@?@C@>CCC@:?C>@ACCBBDDDDACCBDDBDDDC>CA
@1ZZ
GTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGGGTAGTTCGGATCTGATATG
+
;=?DD?DDDF?FHEGFFFBEIIGIII:CECEBFFGGCCFEHGIEHIGGGGFDHCDHDGHB=FC?7CFGDGD7???EAC@DB'9>>B;>>BBBBBCCCDCDC
@200
CCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTG
+
CCCFFFFDHHHHFIJJIIIIJIJJJJJJJJJJJJJJJJJJJIIJGIJJJIIJJIJJJIJHHFHCFFFBDEECEDCEDDDDCDDDCCDDDDCDDDDDDDD?B
@201
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
CCCFFFFFHHHHHGGIJJJJIJJJIJJJJJIIJJGJJJIJJJJJJJJJIJJJJEHIJHDHHGHIJJHHHHFFFFDDEEEDDDDDDDDDDDDDEDDDDDDDD
@202
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
CC@FDBDDDHHFHIIBGEHHHHIGCHHGIIDGCGDG@DHHIGHBFFHGDHGGHFEHHDFDDEEECCECCCCCCCCCCCCCCCCECCCCACCCCCCCDCCCC
@203
GTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCT
+
CCCFFFFFHHHHHJJJIJJIIGIIIJIIIIJHGHIIJJJIIJHIJIJJJJIJHHHFFCDEDDCCCDCDCDDEDCCDDDEEEEEDD@BDDDDBDBDDEEED
@204
CTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTA
+
@@@DFFDDHHHDFJJJJJIIIJIJJJIIJJJIJJJJJIJIIJJIJFHGHJIJIJJJIJHFHHHHFFFFFEDEDDDDDDCDDDDEDDDDDDDDDDDDDDDD
@205
CATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIIIIJJJJJJJIIIIJJJJJJJJJJJJJJIJJIIJGGIJJJHHHHHHHFFFFFFFEEEEEEDD
@206
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
CCCFFFFFHGHHHFHHGIIJIJJJJJJJHIIJIIJIJJJJJJJFIIJJJJJJJJJIIIJJJJJJJJIJJJJJJAEFDFFEEEEEEEDDEEDDDCCCDDDDD
@207
GTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGC
+
??@ADDDDFFD?FB:EF<FFDB2<FFFEFDF9?>D9??DF>DFI?FFB@@3)=@ACFE@6;.7=A7;@@9.;@@@>3@=B@=?ABBBB>@A@:A<81029>
@208
CTACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCCCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
?@8D18:ADD<F>BEFFDFC<CBFCG8CH=CGG87DBB4?=2;@@@)7=7C>@CA'',5=(;>C=CCA5;5'3',03+44+49((+8@:C3(48<@??ACC
@209
CTCTCCTGGCCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCT
+
@@@FFFFFB3DFHIIJGJIIGIIIICCHGGGGCHIIJGHEHGDHIIEECEHJGE@EHF5?ACCCCD@>B@BDDDDDDCDDDCCCDDDDB@?BDDDCDA@CC
@20A
CCTCATCCTCTTCCTCTGCTTCCTTTTTCTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATG
+
?;84+AA:A?<CDEI@DE:C:??CCEEFEDFEEIEBFDCDFIIIAB?DC?DDDBBDE@DC:;CCB=@)8=;C@AA@@DDD?C@DAADDAABA@>>?;AAAA
@20B
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
@@<DADFDFHBDAGEGEG@GHGHIBHIE<:??GGEHG@>FBBGG=FGB<@FGCHIGHIE>EEHFDFFAA@>CA5>CA?,3,):ACCC@?55?<A@CCC@>>
@20C
CCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTT
+
@@@DD?DDBDFB?CBFCCDHIEF+AAF@D>AADHFBBD@<?F<BFFDFBBBDGGHIEEEAC@BBCCGHAGEHICE;=??EEBB@@@C>A.;>?CA@CCC
@20D
CAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAA
+
@CCFADD?DDFHAHEHGICHBEH?GEDBHDEEH<FHHIFIGIICHHHGHGDFGHIGEBFEDHBHIGGB@FHGGCHHFFFECCEFFB>@AA>6>C@ACC@
@20E
CCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTG
+
@@@DDD?DH@CBCFGHEEFHGFHIGFF>?G@:FBBGII@=8C88FFH@G@GE=EIFFHHA>@?@;?ACA@>A>;5;??ABBB?92,4+::BACA:A:4>CC
@20F
CCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJIJJJGIJJJJJJJJJJIIJJJJJJJJJJJIJIJJJIIHHHHGHFFFFFFECEEEEDDDEDDFEEDDDDDD
@20G
CCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCT
+
CCCFFFFFHFHHHJJJGGIJJIJJJJJJJIJGIIIJIGIIIJJJJGIHIIJHHFFEFDDCEECCDDDDDDDDDDDDDDDDDBBDDDDCCCCDDD>BDBCCD
@20H
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
@@@FFDEAHDDDFGIIIDHIFECGEFGBHI@DGHIIIJ9BGH9BFHCGGHFGHEGIIIJFJJGJGCCEFHDC@;@;ACCCACDCBDD;@B@<@CCDCC@CB
@20I
CTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTC
+
@@@DBDFFDDFFHIIGIGJFIJHIHDCHEGFGIHIGHHHCFGCBGIGGHHHGIIIJJIIHGGIGIIGGDEGEDHGGGIHJIEGIEE=ACEEFBBEFFECAC
@20J
GCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGT
+
CCCFFFFFHHHHHJJJJJJCGGHIJHIIJJJJJJJJJHIJDGIFGIJJJJJJJJJJJJGIIJJHHHHHFFFDEDEDDDDDDDDDDDEEDDDDDDDDDDDDD
@20K
GTGGGATTGTAACAACCAGAAATATTCCAACTATAATAGTAAGTATGAAACTTGTTTCTGGTATCCAAAAATCATCTTTCGGTGGAGCGTCAGTGGGCTTT
+
CCCFFFFFHBFHHJJIJJJJJIIIJJJJIIIJIIJIJJJGJJJGIJJIJJJJJIHIJGHHIHHGIGIJJIJIIJJJIJJIHGCDBDDCBBBDDDDCDDDDD
@20L
CAAGGGATCTCTCTGTTTTTCTGGGGACAGCAGATCTGCCAGAAATTGAGGGTGAATGACAGCCTCCACCTTGGAGACAAAGACCTTCTGAGAACACAGCT
+
@@@FFFDDHFHGDIBHJIIFGEHIJGGH@EHGHGGHGIFIGECBDFGDHIIECFGGHHIEGGGGEEEHHFFFFC>@CDEDDCCDDCDDCDECDCCCDBBD3
@20M
GTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTC
+
@@@DDED?DDFHBGHGBBEEEHGGF:DHEGBFGFHGGBAGHCGEFGGGECEEEHHEBAA>CCCCCBCC@C>CC@CCCCCDCDCCBB?@?:0<B-8CDD:@C
@20N
AGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTGTGCATATCCTTGAGTGGGCTGGGCGG
+
?@@DDDDDAD?FF>F:C33AFB:<33CDF6CBFF9?FDC?4B<@9?BAEBD99B@F>DFCFGEEGIFD'5;>5+9+:A>@@3>>A:A>A>B?28?.)<<@>
@20O
CTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJFGIJJHIJIJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFFFFFEEEEEDDDFDD
@20P
CAGGCAAGGAGGAGGCATCCTCAGTCCCCATGATAAGGAGATTGCCTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTT
+
@@@DDDDAB;FDCB@?;??BHEHAGE?EAHIEIBFDBDFDB?BBDHGDFBAFHICCGA;AE;C>=B66=@CCCCCCCC;AAB@@B::,:?>@ACCCC:ACC
@20Q
GGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGG
+
?@@FDDDEDHHFFHFAEGIGGEHG=GGEIIBHJIHBHHBCDDDFF>>CEDCCCCBD8??=<B;?BDDBCCCBACCDC+4@?95<5<>BB?A?@<<??>C<B
@20R
ACCAGCACCAGTTTGTTGAAATTGAACTTGTAGGTGAACCGTTTCCCCTTGGTCTTGTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTC
+
@CCFDDFFGHFHHGHHGEEHHGIJGHHHIJIJIIHCEHIGIIIJIJJJJJIDBGHIGIJGHCHIIJIIIFHGFFDDDE;>CEECCBDDDBBDBDB@@>B
@20S
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
C@CFFDDEGHHHHJIIGGIICHGJIIJGHGIIIGIJJIIIJIGIIJJIJJJIJIHGHIIGEHIIICHBHIEEHGHHFFFFFFFECEEEDDDDDDDDDD5<<
@20T
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFFFFFHHHHHJJJIJJHHIJJJJIIJJJIJJJJJJJJIJJIIJIIIIIJJJJ@FGGHJHHGFHHFFFFFFACE>AD@CDDEDDDDDDDDDDDDDDDD
@20U
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJIJJJJIIJJJJJGDHDHHJIJJJJHIHIJBGIJJJJJJJJIJJIJGHGHGGHHHFFFFFFFFEEEEEDDD
@20V
CTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGA
+
CCCFFFFFHHHHHJJJJJIJIFHIIGIHJJJGIIIHGGIIGIIJGJIIHIIJIJJJHHHHFFFFFFEEDDDDDDDDDDDDDDDDDDDDDDDDDDCDBDDB
@20W
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@@@B7DDD:?<FFGIEBEB?HFFE61:??0?*9B?BDEE=2BBB=.5@37CEEA;=3=@B?B>;>A@;.5;>;(;(55:55:>@:A>>@+:AB34>:@@B?
@20X
CTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJHHGIJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJHHHHHHFFFFFFFEEEEECCD
@20Y
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGC
+
@@@=?DDDFHFFHHIIIJJGHGIGHEGGIIGCCBG?0?FF?FA=C>A@;FGHIIIHECA>A@DEF@=A?;>@CCCC3:ACD>CB:A4@CA>>:>AC<CCCD
@20Z
CCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJGIIJJJJJJIJJJJJGIIJJJJHHHHHFBDDECDCCDCDDDDDDDDD
@210
GTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTG
+
@?@FFDDDFHFFCGHGHBGHICDHFHIIGECH9DGEHIIGGGFHIIE1AA;DHIGHGIEEAHEDFDDEF;>CAEEECCAB?CCDDECCCCCCC@>@CCC>
@211
CTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCC
+
@B@FFDDDHFHHFHGGIJJJIGIIJIHHIIIIIGGGII;FFEHHIIGHHHGHGFFFEDEEEBDD@BCCDCDDBDDDDCCD>CCCDEEEEEDB?<@8@>B@
@212
ATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCC
+
@@@DDDDDFHBHDEEDF4F:CAEBHI8?EDHI@HEIBHGF@EEGHD<FFE>FC7CC;C@CCECGFHEEEEHCEDE.7;@;>ACCCC?>>CCCDCC(,9CC
@213
GTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCT
+
@@@DF?DBFHGFHIFGIDGIIIIACGGGGFHGIFGDHHIIGIIIIIIFIIIIGHGGHHGFDHGD@CDFFEEC@EEECCCCBBCCCECDCCCCCBCCCCCCC
@214
CCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGT
+
<@@FFFAEHHHHHJJIJJFHGGIGHGIJIJJIJJJJJJFGHGGIBHIJJJFHHIJJJJJJGHGHEEF?BDDBDBDDD:?BACCDDCDDDDDDDDDDCDCBB
@215
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGCCTCAGTGGGCTTGTTTCCATCCTGCGGTCTAAGAGGAGAAATA
+
CCCFFFFFHHHHDHIJGIJIJIIIIJHIIJJJJHJIJJIIIHGIJJGIFHHIJIIIIIJGIJJGIHHHHFFFFDEEEECDDDDDDBBDDACDDDDDDDDC
@216
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
C@CFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJIJJJGIJJJJHEFHDFFFFFEEEEEEEDDDD8?DDBDDDEDD>CB
@217
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTG
+
C@CFFFFDHHHDFHGGHIIJIIHIGGEGIIIIIGIIIFGGGGGIEHIJIGIIJ@@EHDECEEHHFFB@@ACCECDDCDCCDDDDCDDDACCCCCCCDB@C?
@218
CTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJBGIHIJGHIJJJIIJJJJIIJ@EHBHHHFFFFFFDDDEDD@CCDDDDDDDDDDDDDDDDD
@219
AACATACTCCTTCACAGCTTCTGGTGGGATCTCCTTGGGTGCCTCAGGAGCAGGAGGTCTCTGGGCTTTACGCTGACGCCGGCGGGGGGCCCGGGGCTTGC
+
?;@D=DDAAADFBGDFDBGCC>C<A<2@:9;?9?:DEI??DGG@30B;<?BCEA1@F-77=)=CHEEED@;?>='9=/',8999955993<>9&5&5025+
@21A
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
CCCFFFFFHHHHHJJJJJIIJJJJJJJHHIJJIJJJJJJJJJJJJJJIJJJJJJJJIJJJHHHHHHHFFFEEEDCCDDDDDDEDEDDDDDDDDDDDDDDDD
@21B
TGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGAC
+
CCCFFFFFHHHHHJJJJJJJJJEGIJHJJFIJEHIIHHGGBBCBDDDDBDDBDDDD<9BDBABCDDDDDBDBDBDDDDCD?CDEDEDDEDDDDDDDDDBDD
@21C
CTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTG
+
CCCFFFDFHHHHGJJIJJJIJIIJIGHIJJJJGIGHIEEIJ)?FGFGHJJIJ>FHJGHHHFFFFEEEDEDCDCACCCCDCCC@DDDDDCDDDEDCDDDDCC
@21D
TCCTGGTCTGTGGAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCC
+
?@BFDEFFHHHHHJIGIIIIIGIIJJJJHHGHIGIGHIIGGIJJIGIJJHEGBDBGHGDHHIJIIIJII@HGHHIIJIGHHHHFHFFFFFDB@CEEEEDDD
@21E
CTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGC
+
CCCFFDFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJHIJJJJJJJJJJJJJJJJJIJJJJHHHHFFFFEEEEEEEDDDEEDDDD
@21F
GCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTC
+
CCCFFFFFHHHHHIJJJJJGHHJJJJJJJJJJJGIJJIJJJJIIJJIIIJIIJJJJJJIJJJJJJJJIJJJJIJIIHFFDDDDDBDDDDDDDDDEDDDDDD
@21G
TGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGC
+
@?@BFFFFGHFHFGGEHHCFEEEGHHFHGGJI;1CEHGGGGJIJFHDHGEIJIGIJIEIFEHJBHHIACFD;B99<ACCCD(9::>BCCAACB+:?BBDDB
@21H
GTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGT
+
CBCFFDDFHHHGHIIJIJJJJIGGIIGIGJJJJGEHIJGGHHIGIGHIJIJEICHHEFFFF@DCEDDEDDDDDDDDD>BDDDDCDEDCDDDDDEDDDD5
@21I
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
@@@DDDDD??CFFGBBHDHBCHH9CFF<CEH?FHIGHIIFHIBFCFGGCGEHIII;CHC=DHHEBB=;ACCA9AB5>@CCCBBB<6?>CCCCECEAC@@C@
@21J
CCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATT
+
@C@DDFDFHHFDFIIEBG@HHGIIIIGEHGHCBGGIGGG@FGHEHDGFHIIIIIIGIICDHG=CEH@HFHA>>CDFFFDBCCCDACC=AAACC=888@@C
@21K
CTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAAAATGGACTTAAGCTATAGCTTGCTGGGAAGGAATCTGGAACTGAAGACCGTTT
+
@@?DFDEFHG?FHGGIIIIIJGIGIIGHIJIJJIJIIIGHGIJJJGIHJDIJJFIHIJJJFIHEHIGHJIGGGHHHFFFFDC>AACEDDDDDDDDCDDBBD
@21L
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGG
+
@CCFDFFFHHHHHIIJIJJIJJJJJIIJIJJJJJJJJJJJJJJJJIJJJIIJJJJJJHGHHEHFFFFDEECEEEDDDDDDDD9@CDDDDDDDDDDDDCDDD
@21M
GTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
BBCFFFFFHHHHHJJJJEIJJJJJJJJJJJJJJJJIJJJJJJJJJIIIJGJJIIJJJJJJJJIEHIGHHFEFEDEEEEEEEEDCCDDDDB8@B@5@CDE
@21N
CTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHGGFHIJIJIIIGGIJJJIIJJJJJJJGGGGHHIGIJJIIFHIJJHFDDEDDDDBDDDDDDDDDDDDDDBCEEDDDDDDDDDDDDEDDDDDCC
@21O
CCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJCGIJJJJIJJJJJJHFDDDDDDDDEDDDDDDDDDDDDDDDDBDDBDDD?DDDDDDCDDDDDD@CDDBB@
@21P
TCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJEHIHIJJJJJJJJJJJJJJIJJJJJJJHHHFFFDEEEDEDDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDD
@21Q
TCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGG
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFEEEEEEDDDDDDDDDD
@21R
ACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCG
+
C@CFFFFFHGHHHJJJJIJIEGGJFIIJHHFFFFFEEECFEFDDDBDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDBCDDDCACDDDDDDDDDDD
@21S
CCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGG
+
=@@DFDFDHHHBHGIIDBGHGGDDHEF@DHHFHGGGHIEGH@DD<AFHIIIGGIIEEEACC@CE@@BCCEC@CCBBBBCCCCC@ACCBB>BC<@CCCCC8@
@21T
TTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTC
+
CCCFFFFFHHHHHJIJJJJHIJJJJIJJJGIJJIIGIHHJJIIJJGIJJJJJIJJJIIJJJJIJJJHHHFFFFECEEEEDDDDDDCDDDDDDCDCDEEEEC
@21U
CACCAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATG
+
CCCFFFFFGHHHHJCGGIIJJJHIJJIJGGIIIJJJJIJJIJJJJJJJJJJJJJIHCCDEEDDDDDCDDDDDDEDDEEDDDEEDDDDDDDEEDDDDDDEE
@21V
CCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTC
+
BBBFFFFFHHHHHJIIIIJGIJJJIIIIJJJJJJJIJIIIIIFIIJIIJJJJJJJIJJJIHIIIJHHHHHEFFDDBBBDDDDDCCDDDDDDDDDDDD<CD:
@21W
CCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTC
+
CCCFFFDFHGHHHIHIIIIGEHBHHJJJIGGIIIJJJGGIJIIIIIGCHGIEHHFFFFEDDEED>BDDDDDDDDDCDDDDCDDDDDDDDDDDDDDD09BBC
@21X
CCCGTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCT
+
CCCFFFFFHGHHGIJIIJJJIIJJJIIJIJJIJIJIJJJJJJIJJJJHIJJJJJIIHHHHFFFFCDEEEDDDDDDDDDDDDDDDDDDDDCCDDDDDDDEEE
@21Y
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIIIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHHHFFFEEEEEEDDDD8?BBDDDDDDDDDDDDDDDDDDDD
@21Z
TGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCT
+
CCCFFFFFHHHHHJJJJJJJIIJJJJJIJJIJJJJJJJJJJIJJJIIIJJIJJJJJJJHHHHHHFFFDEEEEDDDDDDD8@BDDDDDDDDDBDDDDDDDDD
@220
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
CCCFFFFFGHHHHJJIIJJJJJJIJIIJJJJJ?FHIDFHIJIIFHIIJJJIFHHHHFFFFFFEEEECDDDCDDBDDDDDDDCDEDDCDDDDDDDDDEDDCD
@221
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAAT
+
CCCFFFFFHHHFHJIIJJJJJJJJIGJJJIIJJGHJJJJJIJJIIIIJJIIJJIJJJJJIIJIIHHHFHFFFFFFDDEEEECDDDDCCDEDDDDDDDDDDE
@222
AGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATC
+
?@@FFFFF>FFDFHIIEGHIEDGGIGIIIIIGGIIIIIIIIIHFGDHGEIIIIHIIIIHHEFFFFBDFEEDEEDDDDDDDDCCB@BCDCDDDDDDDDDA
@223
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@CFDDDFHDHHHFEHFIDFHIIJJIGGHIJICFGHIIJGEBFGHJDGHGJFIGDDGHCECCEHH>CFDCDFCD@CAAC@CCABDA<55@CCCDDDE4
@224
CCACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIJJJJJHHHHFFFDDDEDDCDEDDDDDDDDDDDDDDDDDDDDCDDDD
@225
CTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJGIIJJJJJJHIIJJJJJJJJIIJJJJJJJJJJJGJJJJIJJIJIJIIJHHHHHH?DFFFFF
@226
GCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACG
+
CCCFFFFFHHHHHIHIJJJJIJJJJJJJJJJJJJJJGIJIJIJIIJIJJHIJIJJJJJJFGHIGGHIJJJJGGIHHHHFFBDFFFEEDDDDDCDDDFDEDD
@227
CAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAGGAGTAGGATATTC
+
C@@DFDDDHHGDFGGHIAFDIEIJJJJJJJGHIIJJJIJEIJJJIIGGDFGGHHGIHHJGGIIIGHAEHAEHEDDEFFEEDECBDCCCC@@5>CC@CDDED
@228
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTG
+
CCCFFFFFHHHHHJJJJJJJGIJJJDHIIJJJJJJJJJJJJIJEIGIIJIJJJJIJJIJJHHHHF=AD;CCDDCDBDDDDDDDDDDDDDDDDDDDBDDDDD
@229
ATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTAGTACTATATCAGTTTCGAACTGGCTGTCTTTATGAT
+
;=??DD?A=DDCA:EE<A33<<A?1C11CDIII>:00?D99B9D99)?98B<?88BEI4.)8A)=;-).77=A777)==7A(;A>;A>55,,--,>A5(:;
@22A
CCTGCCCATAAACACCCATGCTACTGGGGAGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
1=:AD;D<;C<C:CA28C;:<A99C998?)0:0B???0?8.7?;3=C447=8=A77=68-:;7@33(66>@55--;>:A:>5;>35>:AAAA?3<>3834+
@22B
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHHHJIIIJJJJJJIJJJJJJIJIJJJJJJJJJJJJJJJJHJJJJJJJJJJJJJJIJJHFHHHFFFFFFFDDD>BDD@CDDDDDCDDDDDDD
@22C
CTGAGGTTTGCCAGCAGCCAGTGTACATTCCGAAGAAGGCAGCCTCCAAGACACGGGCCCCCCGCCGGCGTCAGCGTAAAGCCCAGAGACCTCCTGCTCCT
+
@@@DDAADHHDHHGI@D@FED<AA<A<FHHFBFHIIICAFDEHEHGEHIICGHIEHIHFDECBBBB55>>5>;@><?8?<4@BBB(8?C?BCCBC@>@AC3
@22D
CCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTG
+
@C@BDDFFHHHHHIEHIGIIIIIIGEHIIIIIIIEGHGIIIIGII?GEHHIICFFHFHGGGG'5>B;@CCDCCACBDABDD8ABDACDBCCDDDDACCCDA
@22E
GCTTCATCTCGGCCAGATACTGCATCCCCTGTGAGATCTGCCAGGCAAATGAGATGAGGTCGCCCATGGTGAGGGCCCGCTCATCCGGGTGGTCCAGGG
+
@CCFFFFFHDHGHIJJJIJIIIJJJJIJIIJEHIIJJGIIJJJJJIHGGIJJJJJIGI@FGGIIHGHFE;@DFCCCDDDD@DBDDDDDD5>@>CCCCDD
@22F
GGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGA
+
@@@DD<@;DFFFFHH@DHFGGBFD;?;CFGGIGIGIFHGIIIEHEHEGAGII@EHHIB>CHHA>ECDEDDDCDC<CCDCCC5>CC@BCAA@CCECCCCCD
@22G
TGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATAT
+
B@@FFFFFHGHHGJEGHIIJJJJJJJJJGIJJJJIJJIJJJJJJJJJJIIIIIJIJJJGEIJJGIFGHHHHGDFFFDEEEEBDDBDDDCDDDDDDDDDDDE
@22H
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJIJHIJJJJIJJJHIJFHIJJJJIJIJIJJJHHHHFFFFEEEEEEDDDDDDDBDDDDDDDDCCD
@22I
CTGCTGCGGCATGGAGGGTGGGGGAGGCGGGGGTGGCGGCTGCTGTTGCTGCTGCGGAGGGGGGGGCGGTGGGGGGTGCTGGGGGGGCGGGGGGGGCCGCC
+
@@@DDD>D:FAHHIIIII:?@EHGH>F@<>?9B0&7@16005(+338(+93(+(()557B&0;&58&58)5;>B@9)0(+(:?B&&5&09BBB-55&&&&&
@22J
TTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTT
+
=??D:ADDHHAHHEBD?F<F?<EAHHHD@9<AAD<CE>BD8??F=?D@D?BBFBB9?F>8=F)@7)8=CCHAAA@>EHA?D@DEEEC@B@C>A>>AADCC@
@22K
CTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAA
+
BBCFFDFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJIJJHHHHHFFFFFFEEEEEED
@22L
GGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGC
+
?@+BA:BDAFFFDIEF??HEE?<CGFGEFCEFCGF?*0*:BGA@?FEBFEIEDFECFFFFD;;CDFIA;==>2?B?@@A>C@ABBBABADBABDB@?(9?<
@22M
GAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCT
+
CCCFFFFFHHHHGJJIJJJJJJIIIGIGGIIIIJJGIIJGIJJJIBDEHHHDHIIJIJIHICHIJIJJIJGHHHHFFF8>B=;CCCDDD@CDD??@BBDDC
@22N
GGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCC
+
BCCDFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJHHHHHFFFFFDDACDDDDDDDDDD>CBDDDDDDEDDDDDCCDDDDDDDDDDDD
@22O
AGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJJJJJJGIJJIJJJJJJIGIGHIJJIIJIJJJJIJJJJHHHHEFFFDCDBDDEDCCDDDDDDDCCD9
@22P
CGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGAC
+
CCCFFDFFFHHHHJJIJJJJJJJJGIJIJJJJHIJJJJJJJIJJIIJIJIJJJJJIIJGJJJJIJIIJIIIJIIIJIIHHHHFEGFEFEFFFEEDEEDDDB
@22Q
ATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATGTGCCTCCTT
+
CCCFFFFFHHHHHJJJJJJIJJJJJJHHIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJHHHHHFFFFFFFEEEEEEEDDDDDDDDDDDD
@22R
GGGGTGGGTAACTAGTGGGAGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
BBCFBDFFFHHHHIJHHJJIJJJJJHJJJJJJJJIHHIIJJJ;BHHHHFFFFFDFEDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDEDDDDDDD
@22S
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHHJJJIHIJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGHHHHFFFEEEEEEDDDD8@DBDDDDCDDDDDDDDDDDDDDD
@22T
TGAGATTCCTCTTTTTTTTTTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTG
+
@BBFFFFFHHHHHJJJJJJJJGGIIJIIIIIIGIIHIJJJGIJJEIJJJHFD;@@@BCDCCDDDDACDCDBBA?CDCDDC>?CDD>@CDD>ACCCCCDDC
@22U
GCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCG
+
@@CFFFFFHHHHHJJJJIJJJJ@HIJJIJIFHIIIJIJJIJGHIJIJJIIJJIHIIGGIJJJJJIHICHHHHGFFFFDEEEEDCDDEDDDDDDDDDDDDDD
@22V
CTCCAATCTTCACTATCCGTGGACTGGTATAGTCTTTCACGGAAACAAGGCAATTTCTAGCTGCCAGATCCCTGTGAATGAAATGCATCCGTTCCAAGT
+
@CCFDDEDDFFDDGHGHIGDHHGEGIIHGEHGIIGGHIIIIIIGIGGGIHIIIIIGGGHEHGHIGH@AHHCACEFBDFDEEEACCEDD@CBDCD?CDD:
@22W
ATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTC
+
@@?BBDDDDFFDHGIGIIGIIIGA3<FEHEGABBE?E@FGCHGC??DF@DCGGGIGHCHIIIGGGEHGIGEGEA5@EEHCCE>)??3.;CCD;@CA>CCCC
@22X
AGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
?@@?7BDDBBFFHEAEFFHE3@C@?E@CFGEHFEGG@D?9BBFG79BGHAGIHGGHIIG@3@EA?>CEDDB?=A>CBBBB?;?C?9:>;>CC((+099@
@22Y
CTGCATGTGGTTCCTTCTCTTCTTTCCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGT
+
@@@DFFDDB>FFBEEGEIIJIJHHIAFD@BGIIGIEEGHGGH?F4BGFGE9FGGE7@BGBGGHGGHGIIEAAH)?DEC7BD;>A;ACAC;CC@<A@@D>5
@22Z
GTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTT
+
@@@DFD>?FFFHBGGE@EFGED>C>F@FCHI@HEHGFA:C:C<DGDEFFH<4?DHG9@?FGFHGHHIDBAEFBFGEGGGIH@@GHEHGHHE;?EABDFFFD
@230
CTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCC
+
@@@FFDEFFDFHHGGIHEHCHICHIIIDIIIIGEIIGIGDAHGFHGGIICGEGEHGHEFHIII=FDEHIIFEHIIEC@EHFFGFEFFFFCDDCDD>C@ACC
@231
AAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCC
+
+:?DDDD>F::C?4<<CA?CGFE?AE9EB++*:?*93:?DG3*:B4*8*0BFC@AAA<CDBFCB=F@@CEAF=AE=A>A>BB;7?;AB;63>>;(53=/,8
@232
AGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTAC
+
???DB??AB:2C:<<AEA+3,3AAE?<A<;*1)1?*:DBDE<DBDD0<9?B)/B@CCCDDC;ACCAC)(7=CDCDDDADA;>AAAA>A>AA;>3(;5>(:
@233
CTCATTTCAAACAGGAGCCAATGGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCT
+
@CCFFFFFGHHHHI?BHIHGGIIICGHIIIIJGIIEHIIJJIHJJJJJJIJHIIHII@BDGHIGHIJIIIGIJJIGHG=?CBBDFFFEECCEEBBBDDDBD
@234
AGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGG
+
@@@FDFADACFHAEHGGHIGIGGGEHEGEGEH?BFGHCGGIBGFGHIIDGGIGHDEHICHAADB>BBBCC<ABB?CB<8A?AC@C@?BCBBCCCCCCCCCC
@235
TTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTCCATGATGTCAACATACTCCTTCACAGCTTCTGGTGGGATCTCCTTGGGTGCCTC
+
@@@DDADFHHBHHGFGBDBEA>EGGGBFHEH@<EEGADGG?GDFGGGGICC>?<8==C@CH@FG@G@DHEGA?==CE@;;7?;8?C@>ACDCDC<,3893:
@236
CATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTT
+
CCCFFFFFHHHHGJJIJJJJJJJJCFHJJJGHIIJJJJIGGIIJJJJJJIJJJJJJJJHIJGJJIIJJIEHGHHHGFHF7@?BCEEDDDDDDDDCEDEDCD
@237
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTG
+
CCCFFFFFHHHGHJJIIJIJJJGJJJJJJJJJJJJJJIIJJJGHIJJJJJJJJJEHCFHIGGIGIJIJJJJEHHHHEEDDFDD@DAC@CDDDDBDDDDDCD
@238
CGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
@CCFFFFFHHGHHIAEEHGHHHGIGI?GGHDGEEHGIGGGEHHIHDHGHIJGGHGHEIG<BECCEDACDCD@@CB@A>AC:@ACAC>CCBBB3:@DDCCC
@239
TTCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTT
+
@@@BDDDDHHFAFHHEFBD@EHGHCC@HA@FEB???CFG@DAGGFFGGGIGHBDHDGIFGI@GCDE:A;C@A;DGHE)773?EECEDEECCCCCC;(3;;@
@23A
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGC
+
?<?11ADDA?CDDEAC:AB@@1:CC>DDIDBDA??3;D>9?8?@BBBBCECDCD=@A7A>ACAC>A7?@.7;;;@;>AAA;>A>:>>>ABAA>>A>>A(8:
@23B
CTCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCT
+
@CCFFFAFDDFDGIHBGHGGGBHFGHCHA9*8?BBGIGGBBFCFB8@GE@AE>CECDE?@D=9?BDD>AC:ACC:>@@CC>>@BBD>CCCDC8@B@ACDC
@23C
CTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGT
+
CCCFFEFFHHHHHJJJJJJJIHJGGGIJJJJJGIJIJJJIIJIIFHIJJJJJGIIJIJJIEHIIJEHHHHGHGF?DFFEECEEEDDDDDFDDCCDDDDDD>
@23D
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIIJJJJIJJIJFHIJHHJIJJJJHIJIIIHHHHHHHFFFFFFFEDEEDDDDDDDDDEDDDDDDDD
@23E
CTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTG
+
????ABD:ADDCDEEDEEIIAFIEAEFE@FCBBEEDB9CCD?C6@B<BDDD99??BCEACAEA@CCD><A>29>8??:>AA><AA4:>>>A32<>AA>?;>
@23F
GTCCCGAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGGCTTGAGGTCTCCCCCCGCC
+
;@<BDDADHDBDHGG@BFDHIIHBCHIFI49@?@;D?FB:F;C@A@CAB1=;BC>:;@@B75;B;&0<::A;@-90<88?&+889(:<3(+(4999@350
@23G
AGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATG
+
@?@DDDDDHB4ADGEAFGEGBHAEDAHG@F@BBBGBG@B:?C@F?HD??/??@FFGAAHGIGC)=@E;CEB,;?=(6;1>;5,55>::(>@@@A?<?BC>C
@23H
CTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATCAT
+
@@@FDDFFHHGHDIJIIIGJIJJJJJJHHBGIJJIJJJJCGHFGHIJCGGIEGIBGHJCIIIIIHIIJGHEHEADFF?CEBEEEEDEDDCDDDDDCDECCC
@23I
CATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGC
+
@@@D?DDDDDA?DF@FG;FHGIIIGGGGIIGGHHGCG<DE)?GGC@GGHGB@D>AACEE@@BBD>@@CCCC;?>:=A5>>C:@@@@>@5<BBACCCCACCC
@23J
GGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGAT
+
BCCDFFFFHHHHHJJJJJJJJJJJJJJJCGHIJJIIJJJJJJJJJJJJJIJJJJJJJJJJJJGIJJJJJJJJHHHHHHFFFFF@CCCEEEEDDDDDDDDE
@23K
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
=1=:AAADA3C8:CFFFFEIDEB9:?:AAGBGIFGCECDFFE>DFBGG@:@8=8.=@.=@ACE7=16;=));7;?@>@AB@A;(;@3>?B<>AA3433<<@
@23L
GGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
CCCFFFFFHHHHHJJJJIJJIJJJJJJJJJJIHIGIIJJJJJJJGHJJJJHGIHHIIHHHHHFFFCCEEEDEEDDDDDDDDDDDDDDDDDCEDDDCDDDEE
@23M
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
1:?DABDD==A?<E2AC2<+@E<C?FEF<2<AEE811?DDEEDBDD;D29B?DDI@86;=;C@===C))6CD<&00;9:(:4<4+4B:>B>A>>>:438
@23N
CATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAAC
+
@CCDFFFFFHHFFIGEGGHIIFJIJGIJJJJIGGJIJIJGIIFIIFJJIIHGIIIIJJIJIIIJGEGHGHGCEEHFFFFFDFECA@CFDFDDDDDBBBCDD
@23O
CCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAAT
+
@CCFFFFFHHHHHJJJJJJJJIIIIJIJJJJJJJJIJJJJJIIJJJJJIJJJJJJJJIJIIJJIIJIJJGIHHHHGHFFFFDDDDDDDCDDDDCDDDCCCD
@23P
TGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATT
+
?@@FFFFFHHFHHGJJJJJJJJJIJJJJJJIJJJJJJJIHIJGJIIGEHGGHGDGIEHHGIIIHGHHHHFFFFFDCCCCDEEDDD<ADEEEA@CDDCDCCD
@23Q
TTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJFHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJHHHHHHFFFFFFFEE
@23R
CTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCAC
+
CCCFFFFFHHHHHJJGIIJJJJJJJJJJJJJJIIIJJJJJJJJJJJJJJJJJJJJJJIJJJJHIIJJHHHHHHFFFFFFFFEEEEEDD@BDDDDDDDDD
@23S
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGT
+
@@@FFDFDFHHGGIIEHGIFHIIHHIIIJJJIGIJIJJIIJJJGJJJJJJJJHIJJJJGHHHFF?DEBCECCECCDDACDDCDDD5>CDDCDDCCCDDDD@
@23T
TTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTC
+
CCCFFFFFHHHFHJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJIJJJJJJJJJJJJJJIJJGIHIHIIIIIHHHHHHFFFFFFEEEE
@23U
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGAAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
@@@DDDDB2CBHFH@G@EIFAEHGEHEGHGH@<CCBD8DB??D@G@?BABBFE>.88;=@BH'@C;(.;?CEB,;>AA-5@CC>9<ABBCC>ABB.52::@
@23V
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGG
+
@@<ADADDDBDA?F9ABEDH3AE@CFA<3*89?ACDD??9BBDEE<D>C48C=>@76;@C;A7.?@).7;;?(6;@BCB:A;?B93;>@55,(5+8<
@23W
CTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGAC
+
@C@FFFFFHHGGGGHIIGEHJJJJJJIGGIGIJIIIIEHGIIJIIJIIGEFGDFHEHHGGHEDCHGCGGGGGIJIGCHHEHFH@;;@BCCACCD@CCD@CC
@23X
CTCCAGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
<?<?D>DB:C?DB9<3:2A3CE11@EF<FDF;D3*):??B9DDDFFA3?*8=CFE)8@EEI<EEEE9'9>:;@>A>?@B(,5:::>:(4@>A@B@550<84
@23Y
CTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
@CCFFFFFHHHHFIEHGDHGIIJEGGHHBEHIGGI@GGGGDFFEHIIIDDHEEEFHHBB>BDCDCCCDC?:@CBDDDDDCCDCDDD:A@CDDCCDDBDDD
@23Z
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJGIIJJJJJJJHIIIIJJIJJJJJJIJIGIJGIHHFFF?AACCEEDDDDDDDDDDDDDDDDCDDDDDDDDDDD
@240
CTCAATGATATGGAGATGGCGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGGTTTGTGGAATAGCCCATGAAGAGTAGGATAT
+
@@@ADDD?BCADH@BFEHI+@@EGFGHGGIB9DFFHGHG<?DFHEGCHFDC@CF@FGCGCC@6.7?7??B9?=??CB@>:A:>@?<CA>@CD?4>::C>CC
@241
GTTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCT
+
@?@DDBDEHDHH?E<CFGGIEIGHIIHEHHGHEHGGGIIIGC?DFEDF>BFIEHIGIGCCHFE@>DCCEEEEEDB;;;CCCAAA>CCDACCCCBB@CCBBB
@242
CGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@@FFFFFFHHHHEHGFEBEHHHGHGA:CFDBFHDHIIG@FHIIGIEEDDE@@EGFEA?BB@CA@AEDC>@CCA?CCC@CCB@:@CCCCDCDBCCDDCB?
@243
TTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAA
+
@??DDDDDD?CBDBGB?GIC>FDG:F:F@92C@H@9FFEH<DF9DHD<FH@4FDDHEH8*09?B>@BF4B;==)7)@EHGGA=2AEE>?@:@:;>C:>
@244
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGCGTAGT
+
?;:;DBDDBDFF=FE)@EC@AE:CF>F@CGHHGHGEEGCF3BFDD9FGHGH86CGEAH@;DH7??>EEEDE@CC;CC2=@?BCC5,;>>;@CACC(59>&2
@245
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@@@DDBBBBCD?<EEEABFG>B?E@H@C*:E?8DD?GGD90:BF@BGG-.<F@GG18@G-=?7?=@;?@CBA;=;;@@BBB8=8>;@C@CCBCCACCCA?B
@246
GTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTC
+
C@CFFFFFHHHHGJJFHJIJJIJIIGGIJJJJIJGIGJIIIJJJIJJJJIIIIJIJIJIJJGJJHHHHFFFFDEEE>ACDDDDDEDEDED
@247
GGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTC
+
@CCDFFDDHFFHHIEIIIFHIIIIIIIEGFHGHIIIIIIIIHHIIIIHIIDADGIGIIIEGIAGHAEEAHCDDDFD9AEECECCDDDDDDDDDED
@248
CTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCAT
+
BCCFFFFFHHHHHGIJJJJJJJJJJJJIJJJJJJJIJJJJJJJJJIHIJJJJJJJJJJJIIJJJJJHHGHHHFFFFFEEEEDEDEDDDDDDDDDDDDDDEE
@249
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFDFFBFFHGGIGIIGHDHHGGEGGEHIGIHIIIIGIIDHIIAB<?BFG=ADGH.;;;;@EEEHFFDCCFECEEE>??3>CADDCCCCCCBBB>>@CA>
@24A
ATCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTG
+
???DD8;+ADDDDEEEE68<AFEE?EECBDEIICD>BEDDE10??D(=;1A8/@C3)7)?).;?.?;(.>A@>38=???5:5,>B>4>350;<<:A(+:4<
@24B
CTTTTTAATTCAGAAAGTTTCCCTAAAGTCTTGAAATGATTAAGAATACATTTTTGGTATATTAATCAAATGTGTCAGTTTCTTTATGTTATAACATGTCT
+
@@@FDFFBBFFFFGBHI:CEHHHAHHIIA<FEHHHIGICGGDDDBHECDDHEGIIB0BDHBGBG@H>FHEAA.@.@FH==EA@AEHA>EE?@@DBC:;;>C
@24C
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
BCCFFFFFHHHHHJJHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIIGIIIJIHHHHHHFFDDCECDDDDDECDDDCBDDDDDDDDE
@24D
GTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJIJJIJIJJJJJJIJJJJJHIJJJJIJJJJIJJJJJJIJIJIJJJJJJJJJJIIIGGIGIIHHHHHFFFFFFEEEC
@24E
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
@@@DDFDAHHHHHJIGHIIIHIJGGIIICEHIJJJFCHBGIIBHGGIJJJIJGAHHIGGIDH>EEDFEBCD@EEEEEEAAAACCDACCCCCBBBDDDD<>B
@24F
GGAAGAGTTTGGTAAGACACGTAGAACACAAGTCACCTAACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGG
+
CCCDFFDBFFHFDGGIGIIIJGGHIJJJJIIJJIJJEHGIJJIIIIJGGIIHHGIJGIJJJHGHEHHFBFDCEECBDDCDCDDCBDDCDCDDDDDDDDDDD
@24G
GTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGG
+
??<D=DB8BHFFF::<CFGHGA@F6?DG>FE@GCA?FHGGB9B;***??DGGBF:@@@;=DHIGC@AA?ED9?2=AB=>>55@(;3(>CC>5(,(,:@<<<
@24H
TGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCT
+
@@@FFDBADFHFFGEHHGIGCGHIIIJJBFEGIGHG?DFGCHGJHHGIJJCEHHGIHHHGGFFEFCAD@BDCCB@@DB09BCDCDCC@CDDB@CCDDDEED
@24I
GGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTA
+
=?<=BDDDHHHFDGGBHGGIFCFFF?@BHEEEECFHHCH@HGIEGBHIG@GCDF@B@@FDDD=';55;<?AC@:@CACC@@CCA:@??@?@DB(5<&55>
@24J
TTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCC
+
<@CFDFFFHHHHHIJJJJJIJJJJJJJIJJJJJGJJJJJJJJGIEEGGIIJJJGGGGGGHIJJJIIJH?CEHHHFFFFFFFEEDD@@BDDCDDDDDDDDD
@24K
CTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCG
+
CCCFFFDFHHHHHJJJJJHHIIJJJJJJJJJJJJJJIJJJJJJJHHHFFFFFDEEEEEED>CDDDDEEFEDDDDDDDDDDDDDEEEDDDDDDDDDDDDDDD
@24L
GCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCC
+
CCCFFFFFGDFHHGICFHGGHIDHIIJJJJIIIJJJDHHGGHGGHIGG=EHHFFFFFDECCCEEDDBBDCCBDDDDDDDDDDDDDDDEED>CDDDEEECDC
@24M
TGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGT
+
BBBFFFFFGHHHGIIIJJJJJJJJGIIIJJJJJJJJIHIHJIJHJIJJJJFHIJJJIJIIIJIJIIJHHHHFFFFEEEFEECCDDD?BDDDDDDDACCDD@
@24N
ATGCACTTCTCTTGCCCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGCGGCGCCCCCAGCCCCCTGAAGCCCAGGTGAGGGCCGAAGCCGCCCATCCC
+
@@@DDD?DHHHHH@FGHBCGGGGHIHEEIIGGIHEHGHIHGIIIG@FHIEIEGI>BBCBBBBBBBBBB?CCCCBBBBB:ACBB@BBBBB<<B@BBBB?CBB
@24O
GGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCC
+
CCCFFFFFHDFHHJHIJJJJJJJJJJIJJJJFHIJJJJJJJJGHJJJJIJJJJJIJJJIHJJJHHHHHHHFFFFFFFEEEEEEDDDDDDDDDDDDDEDDDD
@24P
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CBCFFFFFHHHHHJJJJIJJJJJIJJJJJJJJJIIJJJJJJJJJJJJJIIIHIJJIIGGIJIJJJIIHHGHHFCFFFFFDDD8?BD@CCDEDD@CDDDDDD
@24Q
GTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCT
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJCHIGIJJJJIJJIJJJJJJJJFHJJIJJJJJIF<BBDEDDDDDDCFDDDDCDDDDDDDDDDDDDDDDDDD
@24R
GTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGA
+
CCCFFDFFHHHHHJJJJJIJJJJJJJJJJIJJJJJJJJFGIJJJJJGHJGFHIJJHHHHHFFFFFDDBBDBDDDDDDDDDDCBDBDCCDDDDDDDDDDDD
@24S
TCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGT
+
C@CFFFFFHFHHHJJJJJJJJJJJJJJJJJJHGJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIIIIJJJJJJJJJJJJIIIGIIFHHHHHGFFFFFFEE
@24T
CTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGC
+
CCCFFFEAADHFHGGEGDHEHGHIIHGIIGIEHIHEIGIGIIIIIIEIGGHIHIHIIGGGIIEEHIIIGIIIEIIIECCGEHGHH=CEDEFFDEC@@CDD
@24U
CAGATAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCT
+
C@CDDFFFHHHHHIIIJIJDD6BDDDDDDBDDADDDCDDCBDDDDCDDDDDDCDDDDDDDDDDCDDDDACCDDDDEDDDCDDECDDDCEDDDDDDDDDDDD
@24V
AACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTT
+
CCCFFFFFHHHHHJJJJJHIJJJJJJJJJJJJJJJJJJJJJIJJDGIJJJJJIJJJJJIJJHHHHHFFDDECEDDDDDDDDDDDDDCCDDEDDDCDDDDDD
@24W
TCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCT
+
@@@DFFFDFHDHBGFFEGIEFHHIGEHDDHEHEDDEFGEGHIJJFGIG<DGHIGEHBFGEGHE@HEEEEECAHEFFBEFDD39?BDCDCCCDACBD?BB<A
@24X
CGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
@@@FDDDEHHHHFIIFHIJJIGJJDIHIIGIGIHICFFHHIJIIJIGGHIJIIHIIJIJJGIJIADHHGHGHFFFDDACCCCC>AD>@CDCDDDDDDCDC@
@24Y
ATCCGACCCTGGCTCCTCTTCACGTAGGAATCCTCTTCATAAACATCTCGGGACAAGCCGAAATCCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGAT
+
?<?DDD??<D+<??EE>9FDFCC81?)?9C@@*::BD>D>DC<?<89DBDCDIDCA;@?A@D@=A@?5=92:>;(;>AAA>:;9>;5(52>A:>:9::>?3
@24Z
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
BCCFFDFDHHHHHJIJJJCHGGIJJGGGIBDDDDDDDCD8ACDCDDEDDDD@CDDDDDDDD?CACDDDCCACCDCDCCCDDCBBD<B<ACDACAADDDCD
@250
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
CCCFFFFFGHHGHIJJJIHJIJJHIJJIJJJJIIFIJJJIJIJJJIIJJJJJIIIIFGIJJHGHHHHFFEEECD@ACDCDDDECEDDDDDDDCDDC?CDCD
@251
CTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTT
+
@@@FFFFFHFHHHJJJJJIJIJJIJJJJJJJJJJIJIJJJJJJJJJJIJJJJJJII<FFHIJIJJJIJJJJHHHHHHFFFFFFFEEEEEEEDDEDDDEDCC
@252
CAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGG
+
CCCFFFFFHHHHHIJJIEHIJJJJJJJJJJJJJJJJJJJJJIJJJIIIJFIHHHHFFFDEEEEBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEEDD
@253
CATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCA
+
CCCFFFFFHHHHHJJJJJJJIHIJJJJGIJJJJJJJJHGIJIIIJJJJJFGHJJJJJJ=CHIJJIJJJJHHHHEFFFFFDDDDDDDEDDDDDDEDDDDDD
@254
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJIJJIJFHIDHIJJJJJJJJJJJJJJJJIIJJJJJJHHFFFFFEEDDDDDDDDDDDDDEDEDCDDDDDA?DDDDDCDDDDDD
@255
CGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGG
+
CCCFF@DDDAFDHIIIGIIIIIIIIGEHI@6BGGIGIIIIIDBFHHIIIIIGIIGHHHFFFDDBD?CBDD=BDDDDDCCCDDDDDDDBDDDDDDDDBBCCC
@256
GTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGGGGTCTCTCATCTCTTTTCTTTTTG
+
?:?DDDDDC+CFF>?@?EF=FBBF?4CA9@FEFF@3:@FB@FEEE@(?3?7;?@BBD1>/8/8>>3:A;>B>B<3<(5<&)+4>BADBABDBAB:AAAB@5
@257
GACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGG
+
@@@DBDDD>ACFH@BGGHE@CBBFCD?@FGGBGGHGIIIIEGHEGIF=EGGCHHHEHEB>CEEDC@C@BBB09<2?>><5>309<CC@CCC@C@>35559
@258
CTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTG
+
CCCFFFFFHHHHHJJJIJJJJJHHJGHIJJIJJJJJJJJJJJIJIHIJJHHHHHHFFFFFEEEEEDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@259
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGT
+
BB@FDDFFHHHHGJJJJIJIJJJJJJJJJJJJJIJJIJJJJJIJJHJIJJJJJJJJJDDDDDDDDDD@CDDEDEEDDDD@CDDBDBDDDDDDDEDDDDDDA
@25A
CTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGT
+
@CCFFFDDBFHHB>FDEGEHIGHIDGIIIFHIIGIEDG=GCEGHGE>DDHF@FHIGGGIIICDGADEDA;ACFFF.9>';?3<>>AC3>CCCC>@C4<75
@25B
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
@BCFFFFFHHHHHJJHIJJJIJJJJHIIJJJJCHHJIIJJJJIHIJJJJJIIHHHHHFFFFFEEEDEDDDDDDDDDDDDDDDDEDDDDDDDDDDDDEDDDD
@25C
CTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTATTTTTCTGAATGCCCCAACGTCGGGCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJIJJGIIJJJJIJJIJIJJIJJJJIIIIJJJJJIIIGHHHADFFFFEED;>;;ACDDDDDDDDDDDDD
@25D
CACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGT
+
??@1?DD+2:AF?@::D6CFF98;FC@@=E@EE;3=;BD>D@C/38?B99?B95>559,:(+><@BBBB?:A:@:9A@A()&500&0552+4??(835>08
@25E
GCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCC
+
CCCFFFFDHHHHHJJJIJJIJJJJJIJJJJJJJJJJJJJJJJIJIJFHHIJJGIIJJJJJJJJJJIIHIJJJJJIJHHHHGFFFFFEEEEEEDDDDDDDDD
@25F
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CBCFFFFFHHHHHIJJJJCGIJDHIIJJJGGIIJJJJJJJJJJJJJJJJJJJJHHHGHHFFFFFEEEEEEDDDDDDDDDDDDFDDDCDDDDDDDDDDDDDD
@25G
CTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCAT
+
@@CFDDDFFHHFHIGIIHHGIGIIIJIGHIJJIJJJJGIGHIIIFGHIIGIEIJJJJJJIDHH>EH=BD@D@CEC6>>CACCDB@DBCDDBD?@CDDDDDC
@25H
CTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTT
+
CCCFFFFDH?FFFHIDHGGIHGHIIIJIIIJIJJIFJJJJJIIIGIIIIJIIIJIJIIJJJJIJJIJHJIIIIGGIHIIHHGGHHFFFFFFEEEEDEDEED
@25I
ATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJGHHJIJIIIJEHIJHIGHHHHEHFFFFFFDD@DDDDDDEDDDEDDD
@25J
CCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTT
+
CCCFFFDDHHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJIJIJJJHHHHFFFFFEEEEEEDDDDDDD
@25K
CAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCT
+
@CCDFFFFAHAFHBHGJIHHHIJJJJJJJJIGIGIJJGIJIJGGHHIGJGIIIJDIGHHEHHFFFFFFCAACDCCC@ADCDFDCDDDDDDABBBBDDCCDC
@25L
CCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGC
+
CCCFFFFFFHFGHJIJJJJJJJJJJJIJIJJJJJJHIIJJIJGGIJIGIJIIJJJIJJJIJJJJHGHHHFFFFFDEEEEDEDECDCDDDEDDDD@CDDDDD
@25M
TAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTT
+
CCCFFFFFFHGFHIIGGGIIGCGIIGIJGJGHGHGIJDEGGIHEIJJJJFGGHHIIHGGGDFGIJJJECGGGDGCHDGGEIEAHIGGEGGFEDFDFDEFCE
@25N
TGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGT
+
CCCFFFFFHHHHHJIJJJJJJJJJJJ3CGIJJJJJJJIJIJJJJJJJJJJJIJIJJJJIIJGEEHGHGFFFFFFEDEDEDDDDDDDDDDDDDDDDDD<@D9
@25O
GTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATG
+
CBCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJHHHFHFFBEEEDEEDDDDDDCDD;@DDEEDDDDDDDDDD
@25P
ACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJHHIJJJJJJIHHIJJJJJJJJJJJJIJJJJJJJHHHHHHHFFFFFDACEDDDDDDDDEEEDDDDDDDDDDDD
@25Q
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTG
+
CCCFFDDFHHHHH@EGEEGHIIJGDHIIFIGECEHIGHHIIJIJJJJJJIJJGEHHHHHFFFFFEEECCCDDCDCDDECCCD>AACB@?BDDDDCDDDDDC
@25R
GGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTG
+
?<;B?:AAFH@H@@BFABGEBG?ECFBHGE?HCBGHIIFGGGDEGE8?FEHGIDEGIIIII@@=@ABACHBDEEDACCCCCBB@8>:>CCA>A@@ACCC?C
@25S
CTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAAT
+
@?@DBBBADB?AFCEGIBH@E<CHH@ADFHI?BC?GB?FD*9BGAH99D9??BGGHGIHIICCGGD@@;@G;7CEHE@?CHEHH;C7?BD>C66>CCCAC>
@25T
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
CCCFFFFDHDHHHIFGCGIJJJJJEHGEIGGHIIJJJIJJGGIJIFHGGEIIIGIG5AD?B@CECCCDDDDDDCCCCCDCDDDDDDB<BDDDCDDCCCCDD
@25U
GCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHHHHHJJJIIIJJJJJJJJJIJJJJJJJJIIJGIJJJJ@FHJJJDFDEEEDDDDDDDDDDDDDDDDDDDDEDDDDDCDDDDDDEDDDDDDD
@25V
GGGGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
CCCFFFFFHHHDFHFIIHHIJJJIJJJIJGGHHIJDGHJJJIJJIIIJJJJFHIGJJGHHHFFFFDEDDDDDDDDDDDEEDDCDDDDDDBDDCCDD@?>
@25W
AGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTG
+
@C@FFFFFHHGHHJJIIJEHIIJJIGIIJJJGIIJIJIIBFIJJJIJJIJIJIIGHIJJHHHHFFFFFFDCECDEDDDDDDDDCDDDDDDDDEDDCDDD9>
@25X
GGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTGCTTATCTTTAGCCTCCAATTATCT
+
BBCFDFFFFHHHHJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJIJJJJJJJJIJJJGIJJJJJGHHHHHFFFFEEDE
@25Y
AATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCC
+
?????;B?CB?<C<?G@GHEH<EE@?@HHIIC>FHGE<F>DCECC?@?GD@@GGAF==@GDEC>;CHB777?@@CA@B>CC@>5;;@BB:??:::AA@A:@
@25Z
ATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCC
+
CCCFFFFFHHHHHJJJIJJJJIJJJJJJJHJIJIJJJJJJJJJJJJJJJIIJIIIIIJIJGGIJJJJIJJIHIJJHHHHFFFBCDCEEFDEEEDDDDDDDD
@260
GCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGT
+
@??DBDBB?CAC<CGGIE3<CAEH@BEAGHGFIFEFIEDF)?@BBBB@B*?DFECG:B;A@DED@CDEEEB:?BAACABB@A5>BAA@>AA?BBB@AABA;
@261
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFFFFFHHGHHJJIGJJJJJIIIIJJJJJJIGHIJJJJJJIGIJIIIIIJJIGGGGIIIHIJJIHHHFFFFFFEEEEECDD?BDDDDDDDCCDDDDDCD
@262
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGGGGCATATGCAAAATCTCCGGGTTCCTGT
+
@@@DB;4B<<?FA9<FG@7:<CFD3+A+A3)?EC<1*?C4B3?D?BGFFB@D@B2BA815)8@2).=7;C3.)7/='(.(6;@3;;>;;;(',8,+24((+
@263
CTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCACAGATCACTGGGATGC
+
@@@?DDDDFDFHF8CAFG@8CCD??CGG@BCG9:B?DDHAHGFA?HHEIAAFACFHGEAACEFC?;>?BB??CC@ACC;AA;CBCBBBCC>AA@:??BCBB
@264
TAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGG
+
CCCFFDEFHHFHGIIIIJJJJJIJJIJJJJJIJJJJJJJJJJJJJJJIIJJJJIJIGIIJJJJHIGJJIJGIJJIJJJJGFHFHFFBDFFEECEEECCDD
@265
ATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTT
+
@@<DDBDFGHFDHHGIH@FGEHGIGHGG?BFCEFGIGGBFGGBHHC=DGGHJGCHCGGHHHHFFF>CCCEDDB?CCDDCCC@><>@CCDDEDDDDBBBBCC
@266
CGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGAC
+
CC@FFFFFHHHHHJJHIJJJGIJJJJJJIJJIIIHJIJJJJJJJJJIJIJJJJJIIIJGIIJIIIIHHHHHFFFFDEECEEDDCDDDDDDDDDDC@CDE@
@267
GTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGAT
+
B@@FBFFFHHHHHJIJJHHIJJJIJJHJJJJIFHHHHEFFFACDEEDCCCDDDDDDDDDDDDDCDDDDDDDDABAB@<>BDCDDDDDCCDDDDDDDDDDBC
@268
CCCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGC
+
@@@?DDED<?DDDHIECGIIGDH>FFBEHH<CDEHDBGCFHIGHIIGCHCGIH@DABFDGAGCG8BGGIIIIIEEEADCGHHF?B@;@CCCE@@EE@DCAC
@269
GCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGT
+
CCCFFFFFHHHGHIJJJJJJJIJJJJIJJIIIICFHJJJJIJJJJJJJIIJIJJJIJJIJJJIHGIJJIJIJHHHHHHFFFFFEEEEEEEDDDCDDBDDDC
@26A
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@;=DDA>DHHAFHBD<EBGGGGGIGGGIGFHFCHI@@@@GHGHI4?BDDBGG?=FHGGGGGIIH>AB8;B6;;?@;@E;>ACA:@CC5@CB3:=B<CBB:@
@26B
GTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGCTTCTGATC
+
BB@FFFFDHHHHHJJJJJIIJJGJIJJJJJJJJJIFIGGGIJJIIJDHIJJIGGIIGGIIHHFDDD@BDDDDDDDDDDDDEEED@BBDDDDDDDDDDDEDD
@26C
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJHIJJJJJJIIJJJJJIGJJGIJGHIJJIIJJHHHHHFFFDEDEEEDDDD;@DBDDCDCDDDDDDDDDDDDCDD
@26D
CCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCAGG
+
CCCFFFFFHFGHHIJJJJHJJJJIJJJJJJJJJIJJIIJIIJJJJJJGHIJJJJJJJJJJJJJIJJGHHHHFFDDCCEDDDDDDDDDDDDDDDDDDDDDDB
@26E
TCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGT
+
@CCFDFFFHHHHHJJJJJIJJJJIJJJIJJJJJJJJJIJIIJIIJJJJJJIJGIFIJJJJJIJJJJJHHH>CCDFFDFFEEEEDEEDDDDDDDEEDDDDD<
@26F
CTCCACCTTGGAGACAAAGACCTTCTGAGAACACAGCTCATTGATGTAGCTCAGGAGACCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTT
+
@@@BDDEFHHFHHEIIGHJIJGIIGHHIJGIIJJFGEGIIIIGHDGIJJJIGHEGDHBHHIJIGFH;DHDHA=?E>??DDFEEDEACCDDDDCCDDABBCC
@26G
CTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJGIJJJIJJJJJJJJIJIJJIIIJJJGIJHGIHHHGHHHFFFEFCEDDCEFDDDDD
@26H
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGC
+
CC@FFFFDDHFHHGEGHDIGGII>;FGHFHHADBBHGGG?FHBFGGGCGIIEGICAGAHHHFHGHEDFFCECD?CB@CCCACCDCDDDEECDCCCDDCDDC
@26I
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHHHGJJJJIJJIIJJJJJJJJIIJJJJJJJJJJJJJIJJJJJJJHHEHHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@26J
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
@?@BDDDBFDACFEB:2<CFGHIA>GBAGDHEIGEEHGBGHI@DDDFGIIIGBH;;=.@:D@E>G@=AEHF>7;;C36@>AACC>?BBB35(5(,59?<&8
@26K
CTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTG
+
1??=D:?=D4<<:<EE<2CE@F@F?C<E<A9F>+2CB:1?EEE?C?BDF4@D<?DDB*?D4DDC9D4B=BCEE>)=CE4@=7@@4??).=)?@B@DDAA:
@26L
TGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJIJJIJJJIIJJJJJJJJJIJJJJJJIGIIJJJJHHHHHHFFFFFFEEE
@26M
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
@?@DBDDDHHFDH@GD@@FHBH+AEEEDDDCFFBEGI?DGHGII?B<BECHG?DB?D=FC@FGH;7=F>DDHE;=C>=AA?D)99@CCC;A:>A@CCCDCC
@26N
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGT
+
CCCFFFFFHHDHDHGGIIIJJIIJGBHHJIIIIEHIGIIHIHGIGBAHGHGIGJJII7=CEEEHHFFFFFFE@CECDCDBCCDECDDACDDEEDCCCCDDD
@26O
TAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCAT
+
@@CFDFFFFHHHHJIJJIHIIJJJIJJJGHIIIIIJIJJJJJJJHIIIHIIHGIJHIJJJIJJJ=DEIGIHF5?BD:AEDDDD;?A@CCDCDDCDDDDDCD
@26P
CCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGC
+
CCCFFFFFHGHFFGIIJIJJJJJJGIJJJJIJJJJJJJIJJJJJIIIJJJGIGIJHHHFFFFFFDDCCDDDDEDDDCDDDDDEDDDD<CBDDDDDDDDDDD
@26Q
CTTAAGCTATAGCTTGCTGGGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTG
+
?<@DDAADD?DFFBA:EGIEGGEH=ACFGHIEC?GEHIGGEDGH@FHBGHGFHIEIBC=F@F=@EG@EC>EEED:;@BB??@CCCCCCB@?@?CCDC?<BB
@26R
ATAGGTTGCAGTGGTCTGAGGCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATC
+
CCCFFFFFHHHHHJJJIJJJJJIJJJHGIIJJJJJJJJJJJIJJJIJJJJJJJJJJEHJJIJIJJJJJJIJJHHHHFFFFFFFFDD>BD@DDDCDDEEDDD
@26S
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
@@@DDDDEHHHHGGHFIJGIJIJIIJIJJJJJJHJJIIJJIJJIIIGHGGIIJIJIGEGJIGGHFAHEDEFFDCBA@CDDDDDCCCCDCDDD5>BD9CCCD
@26T
GTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGGTACACTGCAGGTGGGTG
+
?=?DADD)ACDD:E:<1:E<11**CD@DDD9BDEIBDDDB@38B<==.=78.@@77=;6==A?77);;;AAAA?>3(55823;05>9>3+++:9>(42&))
@26U
GTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGG
+
@@<BDDADFFFDFFII4<C3AD+CEHIEICGEEF:?G@<DFEEEGI68?FE==?BF>;CFIE>EE@;CEFFDBB@@?AA>4<:9>DBBDDBABB:@??1?<
@26V
AAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCT
+
CCCFFFFFHHHHHJJJJGJJJJJJJJJJJJIJJJJJJIJJJJJJJJJJJJJJJJJJFHIJIJJJJJJIGHHGFFDDD?CCBDDDDDDDDDBDDDDDDDCCC
@26W
GCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACAT
+
CCCFFDFDBFHHDGGIIIJGIICGEHIIIJJJIIEI?ECB?GGIIGGIJID>FDHEHIG@GHHHHEE@:CHIGGC@EE)?E?@7??CCEEED@CDDDDDDD
@26X
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGT
+
@@@FDFDEFHHGHIEIGHIJIAEHHHHGI?EGGGHHGGIIDGDGGHFHIJJGIEGGHIJJJJ:AEEDDEDCED@CEDCDDDDDBDDDDDDEDEEECDCCDC
@26Y
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFFFHHHHHIJJJIJJJJJJJJJJJDDDDDDDDDDCDDDEEEEDDDDCDDDBDDDDDDDDDEDDDDDDDDDDDEDDDDDD>BDDDDDDDDDDCDDD
@26Z
TGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGT
+
CCCFFFFFHHHHHJJJJJJJJJJJGIJJJJJJJJJJJIJIJJJIIJJJJIJJJJIJJIIJJJJJIJJHHHHFFFFEEEFEEEDDDD=@BDDDDDDACDDD@
@270
CCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGG
+
CCCFFDDFHHGBFDIIIGJIIJJJJJJJJIHGJIJJJJIIFHIJJIIIJJJJIJJHFEHEFFFFFEDDCEDDDCDDDDDCDDDDCDDDD<>B@DDDDDDDD
@271
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
@?@DDDDDFFHHFIIIIIIII<@EGIGIIIIFGGDHDGGGIIIEGDGFFEEEIIIIIIGHHHFDBCEEEECC@C?A(55>:AACCCDCDCCBCC@ACCCC
@272
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
@CCFFFFFHHHDHGHIJJIJJJJIIIJIIJJJJJJJJJJJJFIJHHIIJJJJJJIJHHHHHHHFFFFFAEECCDDDDCDDDDDDDDDDD9ADEEDDDDDDD
@273
GCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCC
+
?<?:BDDDDDDA?EBE<);4;/(.=?C)),777)6;(.6.55;(;>A5::>5=?,5>>3>(555;4((+28>++<(4>>>191++34>(3++4>A>4>4(2
@274
GGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTA
+
CC@FFFFFHHHHHIJJJJJJJJJJJIJJJJJJJJJJJJJJJJIIIJJGIJJJBDFCFHIJIIGIIJJJGIJIJJHHEFFDCCEEDCCDDDEDDDDDDDDE
@275
AGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTG
+
CCCFFFBDHHGHHJAFHIIJJIJJJEGGHGIJJJJJJJJJJIIJJJJGHFHIJJJJJJEHHHHHFFFDDEDDDDDECEEEDDDDDDDDDFDDDEEDDDDCD
@276
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJJJGIIJJJIGHHIJIIJJJIJJJJJJGIJJGHJJ7EHIGIJJIJJDEEEFCFFFFFFDEDDDDDDDD;?BDDDDDDDD@CDDDDDDD
@277
CTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTG
+
@@@DDDFFHHBHHGHHIGGEHHIGFHGFGGEHEIIHFGHIICFBFGGEHEGGHJGIIGGGIIHIIGHIIIHHFBDB?CDCCC?CCD@>CDDDBDDDDDBDD
@278
CTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJFIIJJJJJJJJJJJJJJJJJJHIJJJJJJIJJIJJJJJJJJJHHHHFFFFFFEEEEEEDDDDDDDD
@279
CAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTC
+
=?1DD:BD>D<?D9?2AEE3<CE<EA@BEFAA?:?CBE<EECB<DDC>DBDEEDEEIDDADE>C)BCE7=@=@CCD==??;@DA9@A6;??AA>>;AAAAA
@27A
TGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGG
+
@@@FFFFFGHHBFIIIGI@GIHIGIIGBBFFD;?GDHIEDFHIBHHHFFFFEEBECBBBBCCCBCCCB@ACDCCCACCCCCCCCDCCCCCCCCC@:>C>AB
@27B
CTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTC
+
??;DB+B:::2+A<C<EEAAF;3C<ACA@9?A4CCE?*):1C?9::0):?@9DEI:8/B**.)/8).===7.)=4=CED?C)7?CD;)@).7>A;@>A;5>
@27C
CCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCG
+
CCCFFFFFHHHHGJJJJJJJJJJJJJJJJJJJJIJJJJJIJJIJJJJJJJIIHHHHHFFFFFDEEEEDDDDDDDDDDDDDDDDDDDDDDD<BD@DDDDDDD
@27D
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
CCCFFFFFHHHHGIJIGGGIJIIIJCEHIGHGE:?FHAGHJGIJDGHGI<FHJIJIIIJEEEHHFFDCCEAEDDDDDCDCDCDDDDDBDDDDDDEDEEEDD
@27E
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
CCCFFFFFHHHHHJJJJJJJIJJJJIJJIJJJIIJIHIJJJJ@FHIGIJIJJJGIJJIHHFEFFEEDEDDDDDDDDCDDDDDDBDDDDDDDDDEDDDDDDD
@27F
TGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGG
+
@@@FFADEFDFHDHGBHCFEHAHDGIEHEGIIGGGEHIFFBHHGGIEHHFHGIGGGIEEHHE>CDFFFECEECCDCCCC?ABDC@CDAC>CDDDCCDDCCD
@27G
CGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTG
+
CCCFFFFFHHHHHJJJJJFHIJJJJJJJJJJJJJJJJJJJJJJJJJJJIHHHHHHHHFFFFFFEEEDDDDDEEDEDDDDDDDDDDCEEDDDDDDDDDDEDD
@27H
CTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGC
+
@@<?DDFFCFDHBEB<FB>BHIC>FFH@CHBD9ADFH=G3B:94?9BFEDHIGHDG.=F;=F@A(75??:@DFFD=AC@C;>3>@CB=9?7>@@AAB058:
@27I
TGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGG
+
@CCFFFFFHHGHGJJIJFGHGFGIIJJJJJIIIIIHHIIJIJIJGIHHIJHIIIJJJHHEHH??DDCD;@C@CEDCCCDDDDDCAAADDDDDDDDCDC@CD
@27J
CAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCT
+
@<@DDDFBHHHFHEHGHHCFCFFBHIGEB9EGIIG@GGIGDH@GGGIIEGGEGAFGCHGGGGIEH3@@;=CE>?CEDCDCC;;>;;AC@@CDEA:@@?CAC
@27K
TGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACC
+
BBCFDDFDHHHHHJJJIJJJJJHIJHIJGGIJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJHHHHFFFEEEEEEEEDDDDDDDDDDDDDD@CDDEEEEDD
@27L
GGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAA
+
@@@FFFFFGFHHHJJJIJIJIJJJIJHIIGIIIGIJGHIIJJJIIJJJJIIIIJJHHHFHFFFFDBDDDDDDDDBDDDDDDD?DCDDDDDDBCDDDDDD
@27M
CTGTACTTCTATTTGGAAGCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJIJJJJJJJJJJJJJJJJJJJJJIJHHHHHHFFFFFFEEECEEDDDDD
@27N
TGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGC
+
@@@DDDDDDFDCFGDGIBHBHIGHCGBHDHADDDHBHH?GA=DGGDACEEEFFF??:BBACCCCCC77BB9A(:?4>ACCCC>CC@CCCCCCCCCC5?BC?
@27O
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@@@FDEFFHHHDHHBGHIIGEIHIIIJJIIIA?FGHIIIIGICGGGBDHIIHDGHGEGHIIIJJIIJGEEEHEFFEE;BCCCBDACDCDDCC?CCDCDDB<
@27P
CCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTG
+
@@@DDD?DAFHDFGAEHIII@HDB<ACGIG@DEEH@HECHIIIGICC@BGBHDHGBBDCCB)7CAHHEGGFEEEA?7?B;@A@@@A>83;85):?C>(::@
@27Q
GCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTG
+
BCCFDFFFHHHHHHHIJJIJJJJJJJJJJJIJJJJJJIIJJJIIJJJJIJJJJJJJJIJJGGGHHHHHHFFFFFFEEEEDDDDDDDDDDDDDDDDD9>BBD
@27R
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAACTGGAGAGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGT
+
?@;=1ABA::ADFF<AFFB<<:CGE3+<AC:C<***?<F>GFED<DC*09?3/*7B=1(5@))6)767).7)7;;3?B;?>6;>>A;5--;(3=(59>>A(
@27S
CCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGG
+
CCCFFFFFHHHHHJCGIIJJJJJJJJJJJJJJJJJJJJJJJGIJJJIIIHHHFFFFFEEEEEEDCDDDDDDDEDDDDDDBDDDDDDDDDDDDDDEEDEDDD
@27T
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@?@FFDDAFFHHHIIIGIECGIGGHJJGIBHJIIGGIGGIJGIIEGIHIHIIJIJCFFGEHGCAD@EHFHHFCFCDFFFDDD3;@D;CCDEDD@CDD?BD<
@27U
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGT
+
?=?DADDDHA<CFDDGFE?DHEIGHEE@GCCGGEHCAGGHGB=CHID9==CDE@DGEGE;A>AA7,5=<;5;@;@A<BB@CCCCCECCCCCCC>:AC@9<B
@27V
TCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGC
+
;<<DDDAD>AD<CFGAHEGCHIBEHAFH+AHE+<:3C>BEG3?:BD:??8??<<DF>F:8=F@FGEGGED?B@(.;AC>3(-5-(;5>@>AAC@A:,:,((
@27W
CTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATT
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFCDDDDDDDDDDDDDDDDDDEDDDDDDD
@27X
CTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCC
+
?@@D?DDDAB?2<<EEFDHHCHBHA;CFHIIIDFH?F?FHDBG@GIIIGHGGGHHGIGIDIIC=@H@ACC@DEHHC@>CBDCCACA?C5?AA>>:??C?BB
@27Y
CTTCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGT
+
@@@BBDDDFFFFFGFGG@CFEAF8:CFEGGAE9DDDEHIE??DGIIH9FAAHCGHCHHEE>BBBBCCCCCEDCDCCB?BBBBBA?B@<B<?ACBCCCCDC@
@27Z
CCCAGGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGG
+
<@@D=D?BF??<DEEFEBA@4:,:AFHE43CDFBECE*1?DFDG>D8?D;?B<<F;?CB@EFE>E';<;==?BD>@?;AA>@@B7??5?B(324434>@A
@280
TGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CC@FFFFDHHHHHJJJIJJIJJJIIJJIJJJJGJGIHGJIJJJHGIHJIGGIIEBGHGIIIGIJJJIJCEHHHGFGDFFEEEECEEEEDCCDDDDDDBCD
@281
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CC@FFF@DHHHHFGDIGHIIH?CGHIIIIGDGGEGEHGICHIIDGGGII@HCCC>FEECCEHEEEDECFFFFEA>BA@CCCCCDDDDDDCCD?@A?B@39<
@282
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATAT
+
@BCFFFFFHHHHHIJIJIJJJJJJJJJJJJJJJIJIJHIJJJHIJIFHIJJHIJJJIIIJJIJHHHGHFFFFEEECDDDDCEDDDDDDDDDDDCDCDCDDD
@283
ACCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCT
+
@CCFFFFFHHGHHJJJGJJJJHHEGGHIIIIJEIIGGIIFJGIJJJIJIJJJJJCEHJIGHHHHFF>D>CACCECCEDCCC@CD:ACDDDCCDCDCCDBBC
@284
GCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGC
+
@CCFFFFFHHHHGJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJHHHHFFFFFDEEEEDDDDDDDDDDDDDDDDCCCDDDDDDDDDD
@285
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJCHIJJJJJJJJJHHHFFDDEEEEDDDDCDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDD
@286
GTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTG
+
CCCFFFFF<DDFFDHIIDIBGGJEIJIIGGGIIIIJJJJJGGIJJJJJJJIJHDHFEHFFFFFFCCCCCEDDEDDDCDD@CDDDDBDDD:?CCC:>@BDDA
@287
GTCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAACTTGGCT
+
???+A4A;:=DD>EEAEEFI3A<FECCD<11?D@B?@D@DDDA@B=CE=ADDEI:)7?C>,9;(((..55-55(-,:93>A5(5>;>A>3(4:(+4:>>(:
@288
GGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTAGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTCTCAACGTC
+
CCCFFDFFHHHHHJJJIJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJBGIJJJJJJJJJIJHGHFFDDDDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@289
CTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCT
+
@C@FF?DDHHHHFIIBHIGIBHIIIGGGHGHIIIIJIGGIG0?:8BGDHCHIIFGGGIG>DH7@E:CEHEDFFFFCED@B;>ACDCCDCCDDDDDDDDBBD
@28A
GGCGAGTCCAAAGTCTCCAATCTTCACTATCCGTGGACTGGTATAGTCTTTCACGGAAACAAGGCAATTTCTAGCTGCCAGATCCCTGTGAATGAAATGC
+
CC@FFDADHHHHDCDFHFHIHIGHBBHHIGEHGC;:FHHID9?GGD@D@FGIGFHAAFG@DHEAEE>AHE;BE:@@66>>>?CCCCD@>5;@BACDC:>:
@28B
CAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGC
+
CCCFFFFFGHHHHJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIIIJJIJJIJJJJJJHHFFFFEEEEDECDDDDDDDCCCDEEEDDDDDDCDC
@28C
GTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGC
+
CCCFDAD?CHBHHHGIBHEFGEABHCHGIIGHGIIIIIIGIGHIIEHDHGGEIFIIEHIGI8<BHIIGGC?>C>CC>;BDDD;@ABCC@@BBBB09>CDC:
@28D
GCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCG
+
@@@DFFFFDHBHFIGIEEGIIIGHGHIHIIHIGIICHIIBHDA@FHGBGGFGGFCHAFHIGG@C=EGFEFECEDDBBC>CCEAACC;;;>CCDB@BD8<AD
@28E
CTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFFHGHHJGHIGHAGFHIGIEDDCDFHGHIJJIIFEB9BGDFDDHHGGIIJGGEIJIGIIIIGEHDDE?@;>@BCD>C@CACD,::<:?@B89<?
@28F
GGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGG
+
?7??+A3AF>BFF8G<C<:)??3?FF::DF?BFGFIFIIII?ECF@CE@<A@DEFFA:BDBBDBAC:3>;3;@BBBB>>B>::AB?>@8<<9@BAB@BBAB
@28G
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
CCCFFFFFHHHHHJJIJJJJIJJJJJJHGIIIIJJJJJJJIGHJJJJIIIJIGIJJJJIIIJJHIIJHHHDFEFFECEEEDCDDDDD?CDDCCDD2?@DAC
@28H
CTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAG
+
@=@??DDDHDDAF8CF>AFHIIBHGHCHIIHIA3?FBEH?BF69BDEC;CB@.=C-;EEB>>>A9>?=5=@@=;;@B>9C9CC?@<BCBBCCC>@@CCC
@28I
CAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGC
+
CCCFFFFFHHGHHJJJJJJJJJHIJJHHJIJJJJJJHIHIJJJJJJJJJCHIJJJJIIJJJJJJJJIIHHFFCABBDDDDDDDDDDDDDDEEDEDEEDDCD
@28J
CTCTTTTTCCCCACAGTAGAGGCAAACTTGCAAATGTTTTCCAAATACAATATGCCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGA
+
CCCFFFFFHHHHHJJJHHHIJJJJJJJJJJJJJJJJHIIJIJJJIIIJJJIIIJJIIJIJJIJJIJJJJIJJJJIFIHHHEFFEFFCEEEEDDDCDCDD
@28K
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTC
+
BBCDDDFFHHHGHJJJJJJJJIIJIIJGGIGIIFGHHIGIJDHHCHHBHEEGGHIGI@GCEEHCE<BEEECEEDB@=;CDCCCC@:<CCCCCACCCCCCB@
@28L
CCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGGGACACCCTCAGGGGGGGAGCACTCTTGGGCAGGGGGATCACATGG
+
CCCFFFDEHHHHHJIIJEGHIIIIJGJHJIJJJJIJJJIJJJJJJJJJJGIJIIH/'&)++2&+((+3<@D;5&))((((4(+(2((&)&0&&&+(+(((+
@28M
GTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTC
+
@C@FFFFFDBCAFIIGI>FGHIA@GGGGGE@AEGEEGHGG?@B<D@DE8BGCEHIIE.===D;DEG7C=?CHHF;/?CCCC;5;;@5<9<9<9?<<2>>>
@28N
AAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAA
+
;?@DDDD?DBFBDGGGE?CBEGHEDHIEFHGDHFEHHIIIIGGICFFGGDBBDHGBGEBFHGIH=CHHIGEEGGEHGEEAEH@EHEEEDEECCCCCCCCC
@28O
GTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCG
+
CCCDDB?DHDHDHIGIBHCEGHIIIJJEFHEHJIIIJFGHJCGCEHECHGGGGIHGFHED>@DDBCCEACC@CCA?@ACDDCBDC@DC@ADC?BDBDDCC>
@28P
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTT
+
@@@FFFFFHHHFHJIDEFHIHHGBCFHGHHGEHIIJIIHGIIIJJGIDFFEFHEHIJJJDEGIEGIIGBFEGGFGGHIJFIJJJIFHHGHFFDFCE>AEED
@28Q
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTG
+
CC@FFFFFHGHHDEHGGGIJIIFBHEHBGHIGIGIGJIIJJ<DDHIIIIJGICEHHHEGGGEIGIIIH?EHDEFFDB;ABDDD;<>ACDDEDDDDCCD>@
@28R
CACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGT
+
@@@FDDDDHHHGGJJJ?DEHIIJJJJICHIG;CAEHFFFFFDCDDDDDDDDDDDDDDDDDDDDDCD7@>?CDDDDDDDDBDDDDDD<BDA@CBCABCDDDA
@28S
CTTAAATTTTAAAAGAATAAAACAAATGAGTTGTGGTTAAAATTACAACAGATTCCACTCTAACAGCAATGTCTCTAGGTACAGAAGGCATAACACTATGC
+
@CCFFFFFHHGHHIJJJJIJJJJJJIJJIJIJIEFGGHGIIGHGIIJJJJIJEIGGGIEEEHJIJJGGGGGCHDGGHGH7?ADEFFFFDDDEEDDDDDCCC
@28T
GGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCT
+
BB@FFF<DFHHHFJJGIJJJIJGHIIIJIJJJJJIIIIHIGJIJJHGHFFFFFEEEDEEDDBDDDDBBCDDDDDDDDDDDD+:@:>CCCDCDDDDEDDDDD
@28U
TCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATC
+
@@@DFFFDDFFHHICBGGGIEHEGH?FFGAEGG@AFDAFHHGHGIGHGEGH@@FG@GEHEFHFFDEE@DADB;>BC@CDDD9>CCCCDCCDD@DDD>@::>
@28V
CAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGC
+
CCCFFFFFHG>FDHGIEGGJJGIJGIFIEFAHIDGII<?BFEHGIIJJI<@DGE;DFHIE8CEHGCEHGGECC;BD;@DCCDEDD>;A?CCDC@;@CB>@A
@28W
CTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTG
+
CCCFFFFFHHHHGJIJJJIJJJIJIJIJGIIJDHIGHGJJJJJJIII@FFHIJJJIIJIJIIJJIGHHHFF>BCEDACDD>CCCD>CCDDDBDDDDDDDDC
@28X
CTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGC
+
CCCFFFFDGHHHHJIJGFHGJIJHJIIJJIJJIJJJJJJJJJJJJJJJJJJIHGHIGHIJIHGIIJJHFHGDDFFFDCDDDDDDDCDDDDDDDDDDDDDD
@28Y
CTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAA
+
@@@DFFFF?FBHFHFHIIJIGIB@CHGIJIHIHGGIIJGHG?GGAFG=@B;C.;@EEHGEEBDBDCECEC@ABBCCD>55>ACACCCCDCDCC>ACDDCC
@28Z
CATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJGHIIJJJJIJJJJJJJIIIJIJJIIIIIHIJHEHEFEFFEDDDDDDEFDEDDDDDCDDDCDDDDDDEDEDD
@290
TGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CC@FFFFFGHDHHIJJJIIJIJJIGIIIHIJJJFIIJJEHIJBDHIIIJIJIGIIGIJJJGIJJHGIGFHFBEBEDCCDDEDDDDDCC9ACD@CDB<CB?
@291
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
@@@DDDDB?FFHHIG@HGCF@EFH@GHEHI@CFEIIIIIEAFHAGFHIIF<FGIII@ED9@;@AC@?>@?BCCCCCCCCCCCC?AB<@BBCCCC@@>::A@
@292
GGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCC
+
@CCFFFFFGGHHHIGGGIJJJJIJJJJJJIJJHIJJJJIJJCFHJIGIIJJJGJJJDD&5?ACCCBBDCDDDDCDDCBBDDDDDDDDDDDDDDBBDDDBDD
@293
CAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAAC
+
;@@BDDBDDF<BF@@FHGGHIGH@B@BCCH9F<?BC*??CB9D<F>B:9B;@BCHGIGG4DFF8B38=C=)7=)8=AD@;)=CH;=E:3?77?;6=@;3(5
@294
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
@C@FDFDFHFHH?EEGHICECFHIJJFIJEEBFGGHHH:DAGIIBG=CF@GIEGAHE>A>>@>@BDAACBBBCCCCCC@CC:@CCD::>CCDDDCDDAAC
@295
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@B@FDDDFHHHHHIIJIIJCFHHHJIJIIJIIJJJGIDGIJJEGGGIIIIIJJJJJGJGIFGIEGHIHHGHHFFDDDBDACDDCCACCDDDEEDDCB>CDB
@296
TGCTTATTTGGGAGAGGATTACTGCATTTATTCTCCAGAAAAAAAGGCAGACCTGAGGCATCACATTACCGGAACATTTAAATATGATGACATGTTTCTT
+
@@@DDD?BFH>@F=HI;EHI@HI@BE@B?E@@BFFEDHIIIGGIBHIII1;;@=EIIHFEC>7;;@;66>''3;?<>:;CDC<>CD;444>@:>C:AA>>
@297
AGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATG
+
???=BBDDHDHHFIDCH<CI@HG>HHIEIIIGIHIDGEGH@DGGHGBB9BB@FCHIIGI@@C788@E=CEE;@??ACCCCBB(5>@A@@CCCCA?CBBC>@
@298
TCTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACGCTGCCACTGACGGAAGTTCTCATAAACGTCCTTGGAAATTTTGGAGCGGTCACCTAGGGAAGGC
+
?@@D?D>D+<:<<?FB<FD<@:CEF;?C*?DB???BD@GBBHI@FAHGIEEAB??=B@DEEDE@A;AB=>CCCCC@ACCC?:??<@B@B@CCC@C?CB7?<
@299
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
@?@DDADDFHFFD<EGEDHGGHIIIFEFGCGHG0?DGF>FGFHIDBCHCGGCHIIIIDCEEE?EFF4=?A@C@@CCC@ACCCCCCC?@CCCC@C@A@ACCC
@29A
CATATGGTTATCGAGGAAAGGACTGTAGAGCTAATGTTTACCTTCTTCCGACCGGGGAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTAT
+
CCCFFFFEHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJFFDDEEEEFEEDDEFEEEDDDEDDDDEDDDEDDEEEEEEEEDEEE
@29B
TGATGGAGGAGGTCTTGCCAGCAAAGCAGTAGTTGGGGTTGTAGTCGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGC
+
@<?DDD?DFDFDACGHGHIIIIGIGIIIIIFIGIGGIIFHGIIIFHGIFGGHGAGGHAABDFB8?ABC@;@BCCBCCCCCCCCACDECCCC?BB?ACCCCC
@29C
GGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCC
+
@@@DD;BDHD?FFHGGFEE:CFABGHGFHGBDF<E>DE<FG66@@8??BC8BCBBH@AEGGB@EH=A;=:B;A=>CCCC<@@=93;@CCCC?B8?8?(4:>
@29D
GTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTG
+
@?@DDBB>FBDBH;CGIGHBHI<EAEEGGDEEHGGEHD<D<B<B9BDEGIDIGHGDC)BGGEEHGEGIEEF>AB@;@@@>CCC?C;ABBCBBCCCC:@:>C
@29E
GCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACTGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJIIHHHHHHHFFFFDDEEDEDDCDDEEDDDDDED
@29F
GTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTG
+
@@@FFEFFHHGHDHIIJJJJEFHHIJIGGIGIJJJJGGGIJIJJGIGGIIHIIIIGIJJHHIJHEGIEGHIGGGIIIIJHHHHGEFEFFCCECEEACDCDC
@29G
GTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTT
+
@@CFFFFFHHHBFGHGFHIIIBHII@DGHIIJJDGGIGDFIIJJIJIIJIHHGIJGHJIHIECDGEGIE@CFHH@GIEIEHGHGBHEDDDEECCEEDDDDD
@29H
CCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGT
+
CCCFFFFFDGHHHJIJJJJJJIJJIHIJJJJJJJJIJIHHJJJJJJJJIFHGJJJHHHHHHFFFFFEEDD>@CDDDDDDDDDDDDACDDDDDDDDDEDDDC
@29I
ATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCAGATCGGAAGAGCTGAACTCCAGTCACCGATGTATCTCGT
+
@@@DDFDEHFHDBHGEHBHGGJCEHGIIJJHHJCHEG08DH)?DGBFECEHGI;@C@=@EEEABCFB>B?B9==>ACC>>CC>A>>@>A?BBD24:@AAA8
@29J
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
;?@DDD=@8D>ADAB+ABGFBEAEGG?CGIIGFH?BDGHAAG39B<BB9@BC3CCHI/==(?EEAC:;@BDEDCCCCC(5@>?ACCC>C:('<5:(+8+5)
@29K
GTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGT
+
?:?DDD:?:CA4A<EEDEDCC@DEEB@A@+<A?@EDAEFICDCEDABAB?DCDEIE:9*8DD?D98B@8@@C;ACEEIIEDA(=5?D@A@AA=??AA??=
@29L
CTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
CCCFFFFFHGHHHJJIJHJJIJJIIIJJIJJJJHIJJJJJJJFHIIJJHIJJJJJJJJJJJHHHHHHHFFFFEEEECEDDDDDDDDDCCDDDDDDDDCDD
@29M
GCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCC
+
CC@DFFFFHHHHHIJJJJJIJBHIJJJJICHIGGHHGDBDFDHIHIIIIEEGHHGHHHDFFFCCCDCDDDCBDDDADCCC==>5>CCCDDDBDDBDDDDDB
@29N
CCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCC
+
@@;DADDDFFH?C?CCB@@AAEHEBEFCA@CFGDHCF>:BD@<<BBC@EFGGICFBD>F@F:CFGHIII@;=@C@DHE>CACHBE?CDBBB;ACCCCC>;@
@29O
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTT
+
BCCFDFFFHHHCFHJIIJJJJJGIJJJJJJJJJJJJJJJJIJJIJJJJJJIJJHHHHHFFFFFFEEEEEEDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDD
@29P
GCTCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGCGGCGCCCCCAGCCCCCTGAAGCCCAGGTGAGGGCCGAAGCCGCCCATCCCCATCTTCATCCTC
+
@@@FDADDDHDHHIJJJJJJJIJIJJIIGIGIIJIIIGIIGEEHHGFFDEDCDDBDDDCDDDDDD:ACDBBDBDDDDBDBDD<@CCDDDD??ACDDDEDCC
@29Q
CTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTC
+
@@CFFDDD@FF?BGHB@GHGHGGGGHHEGHGFGG9BDF)9DFHGFAFCAFHGGIIHHCEEFCCDDDDD;@@5>:A5>@C>@=@@BDA>ACDDCDDDDDDB?
@29R
CTGGTATAGTCTTTCACGGAAACAAGGCAATTTCTAGCTGCCAGATCCCTGTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTAC
+
@@@FD?DDDFFDHIGGBHEGGEGGG>FHB;BFHGIGGEHIIIIICHIIIICHGGCH:FGGGGHCEEDBDDHEFFAHHFFFFB@@=BCDDDDBC@C>C;C@@
@29S
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
@@<DDDDDHHH3CGHGGCHIEHIGGCHHGIIIIIEGIIIIEHIIIIEAFHIIICGGHIIICGIHGAGCGI?7=<?DDEBCADC>ACDDCCCCCA?BBCBB?
@29T
GCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATG
+
@@@FDDF8FHHDBEHHGGIGGEHIG+ADAB9B9C4?F>FBG@6?@DHC376'-'(.==@DHEBE>='9=8=C>C?;3<>:>@CD>@:@><>@:ACCDD@CC
@29U
TGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGT
+
CCCFFFFFHGHHHJJJJJIJIJJJHIJJJIJJJJJJJHJJJJJJJJJIJJHJJIJJJJIJIIJJHJIHHHHFFFFEEEDEDDACBDBBDDDDDDDCDDDDC
@29V
AGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTG
+
+:?DD?B?FFABHI@A@<CEFACFE3CG9B<FGG??DDHHGGHA9???8B?B3=FEGD@FCF)@EH4CDEE>EEEC/?>A=6>>C5;>=;9?@CACA@C
@29W
GTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
@@@DDDED?FFHHIIGGIIIGHGIIEGGGIIGHCG9DHHIIIIIIGGG@GIGGIGIIIIIIGIEEIIGGHEDDDFFE.6;ACADDEDDDD?BDDBCDDD
@29X
GCCCAGGTGAGGGCCGAAGCCGCCCATCCCCATCTTCATCCTCAACAGAACCAGAAGGACTTGAGTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCT
+
?@@DDDD=CFHDFEEHIG?AFAADHIEDHHGCFCHIIG@DGEFHGGGD>>EHEDFFBA@@CE@A>5;>>>?:::>@@@B5>@:@@:@>:AC><?@59<59C
@29Y
GGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCC
+
@@@DDDEFGDFFHIIJIIJJIHIJJJIJDHHEEIJJIGFGIGIBGGIDHIHEBFHFFH5@D7=A=EEC>@BBD;=B3;A>AC>CAA:CBDDDDCC@A@CDD
@29Z
CTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHAEHHHFFFFFFEEEE
@2A0
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@BCFFFDFHHHFHJJJJIJEIHIIJJJIIIJJFHEHIJIIJJGIIJDGGIIJGIIIJGGIIIIJJJJIHEHFEDFACCAC;ABBBDDDDDDD<ACDCDDD+
@2A1
AGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCAACGTGCAGAAGGTCCAACATAGCCAGGG
+
;??ABDBADA::A<<?+2A8F9AC?<2?1C?E?D><DD9BD<??D999?/8?2)=8((..8).).)':','6(',,2=(5>35(5:A((5<(((+>11&
@2A2
TGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCAC
+
CCCFFFFFHHHFFGHIIJJIIEEHHHIIJI:DHIIGFHIGFEHFGFFFDDDDDDDDDDDDCCDD@CBCDCCDDDDEDDDDD>C@CCDDDCDDBBD
@2A3
CTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTG
+
@@CB;B???DFBDGFGHBHCHHBCGABGHIGICDHGID?B6G@;7?FCDEG;C=)=;;@CHFBCCCC>=(;?/<8?3999AC<<AB@B?9<B>ACCCCC
@2A4
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGAT
+
@@@DFFFFHHHHHJJGEGGIFIJCFGHHJIJJJJJDHIIIEGIDHHEHIHHIIAEHGEFFFC@CCECECCDDDCD>CCCCDDDDDCDCDDDDCCDBDDDDC
@2A5
GTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCT
+
@@@FFFFFHGHHHJJJJJJJGJIJJJJIJJIJJJGIIJJJEIJIJJJJJJJIIIJIIJJJIIJJJJIJJJJJJIJJJJJJIHHHFHHHHFDFFFFAEEEEE
@2A6
CACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCAT
+
@@@DDDDD?BDF?G<C??CEFBFEACC@HG@F99EDGHGGGGHCAGGFHDI>?@8?DHHHC==BBCGHGIBGBB@@CEBCCB;;>>>A@C:;>CCA>>@C
@2A7
CTCATTGATGTAGCTCAGGAGACCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCC
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJIJJIIJJJIJIJJJIIJJJJJIJJHHHGHFFFFFFFEEEEEEDDDDCDDDD
@2A8
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
C@CFFFFFHHHHHJJJJIJJJJJJJJJIIIIJJJJJJJJJGIJJIJJJIJGIIFGIIJJJJJIJJJIHHHHHFFFFEDEEEEDDDDDDDBDDDDDCDD@CC
@2A9
TATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTT
+
CCCFFFFFHGHHHJJJJJJJJJJJJIIJJJJJJJJIJJJIJJJIJJJIJJJJJJJJJGHFGHIIJJIJIIIJJJJJJIEHHHHHFFFFFFFEEEDEDDDDE
@2AA
CAGCTCGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGGTGGGATCCTTCAGGGCCTTCACAGCCACAAGCATCTTGTCCTTGGTCGGGCTGAGGTTGT
+
@?@DDD@)?DHDBEGHIEH<FEHB?CF??F<6?DD????B6.7@<=CA=E>EC@>2;=A@CC;CA;?;?BB<2?A>@CC3@4>:>3445&9>>5888+2(9
@2AB
GGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTG
+
@CBFFFFFHHHHGJJJIIJJIJJIJJJJJIJIIJJIIIIIJJJIIJJJJHIIIIJJJJIGIJJJJJJJJGIIIIHIIJJJJJGIJJJJIHHHHHHHFFFFF
@2AC
GGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTG
+
CCCFFFFFHHHFHJIJJJJIIJJJJJJGJHIJIIIJIJIIJJJJJIHIIJJJJHIJJJGJJIJIJJGJJIJJJIJIJHHEHHHFDFFFFEEEEEDDDDDDD
@2AD
CTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ;EHDFFFFFEDDDDDDDDDDDCDDDDDDDDDDDDDDDDDCDDDDDDDD
@2AE
ATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTATATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGC
+
@CCFFFFFFHCFHJJJJJJJJJIJIJJIJIJJJJJJIJJJJJJJHHHJJGGHIJGIJEIJIIJJIIGIJJJIGEHHHGFFFFFECECEEDEEDDDDDDDED
@2AF
GTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAAAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATT
+
=::A+:B?:ADD8<<?A43<C::?6)BD>?FF383=<BFF8@;=''').;@@@B?@BB9;5>:>(:@@3:33>ABBA>@>:>@:088?<(2<>4:>@(:3
@2AG
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
@@@DDFFDFHBFHIGFGGGGGHGIGGGGIIGGHIEDHGGHIEEBHIIC@HIJGGGGEEHGHFHH=>A3@A@CCA?=?BBCCCCCCC:C@CCDBBB@<BDCD
@2AH
GTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATC
+
=:??ADADHD:4AF@;<@EB@;;@?E8?;C6C;GHGH>FHHD8BCFBEH@@(=@ED>EHEEEEECCC3;>CCCC;>>CA@>@>?95>A3398>CCD@>CA>
@2AI
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGCCTCTC
+
?@@BAAB;<DB?:A@:E@GFHECHE?FHB?FH6DDFHDB@BGD?CB=8F=F@88<A;5;5=B555:CD:::?(0<5&)>>>CCBB0)<B(+4:<((4+4>
@2AJ
CTCCTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGG
+
@@@DDD?DA??DBBHIGIGHGGEI>DHFGB?DAEDHBGBAFF<CHHGG>DG3?9.:4?C?>CCCCCC?CC?CCC>5:AA@?CCCCCBBBBCCCCC>AACBB
@2AK
AGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATG
+
@@@FFFFFHHHHGJJIIAGIJJJJHIJEGGGIIGGIJJJGGIIDIIJGHHGFH>DFCDFFEEEDCDDDDDDDDCDDEDDBDDDDDDDDCACCDDDDDDDCC
@2AL
ATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTC
+
@@@FDDDDHGHFDGGGGHIIIIIHE@EBHIIICGIGHJJ)?FH-=DCHGHIGHEEIBEE@DCFDEDEEDDDCDDDDDCCCBCAD@C@CC:@CCDDCCDDCD
@2AM
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHGHHHJJJJJJJJJJHIIIJJJJJJGHIJGIJJFJIJIJJJJJJJIIIJJIJJJJJIHGHHHHGFFFFFFFDDD;@DDBDDDEDDDCDDDCDD
@2AN
CGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGG
+
@@@DADDDFDHFB??EFH;FDHIII@CHHCDE<AFHEEGBHGIGIGEHIIHGEGHIGGIG>FHEGCCHCHCFHE@GEGIIEHFHHFECDEEEEDCCCCB
@2AO
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@<<DD?D;?DDFB;+:E?;BE@D@FH?EFGCGFFCGBF4?<GF-;@FFFEFADEA=?EE>C?77.;?@AC;@;=?B,;@;5>>BBB>ABB::>A<BB@(:A
@2AP
TGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTC
+
@@CFFFFFGGHFHJJIIIJJIJIIIIIIJIJEGIJIJJJJIJJGIJJJJIIJIIIIGIJGIIEGGGIIGHGGHEHFCCEACFDFFFFEEEDEDEEDDDDCD
@2AQ
CCCATGGGCCCTGAGGAACTTATTCAGGTCTCCATGCTTCATGTATTCAAAGACCATGATGAGGGGGTCCCCATCGCCGCACACTCCATAGAACTTGACA
+
@@@D??DDDDDDDGH7DDDFCGB99CC@*@EFIGIGI>BEFGIBFDGGEGI9FGGH<FHGGGIGIGF>ACCCCCCB@B6=<5>?9CCCACCACCCCCCA@
@2AR
CCCTGTACTTCTATTTGGAAGCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGC
+
@@<?DDBDD?:ACBADFHIGIGIEHBHICHGHGHIICH@F@GHCGGH@AF9BGGGI;;;FH)8BEHGCFFHGGGG=.)7?A7?77;@DEECACCACAC>CC
@2AS
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGCGCCATATGCAGACTGAGCTGCATAGGCGGCCTGGGTGGTGGTG
+
?@@?DD:=CD+ADFF<C9B:ECB:CFFIFFD@F@F;;D?DFCEDADFE<FF2:FCE;)4@AA=>B>@@DDCABCA;A9;>A3;@(35500<88+)5)28)8
@2AT
CGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGA
+
CCCFFFFFHHHHHFHHIHJIIJJJJJJJJJIJJJJJJJJJDHIJIJJJJJIIJJJJJJIJJJJJJJJJIGIJJJJJJJJJHHGHHFDFFFFFEEEEEED
@2AU
TTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGC
+
CCCFFFFFHHHHFHIIIJJJJJIJJIJJJJJJJJFIIJJJJHIHIIIHIIJIIJJIJJFHIIHIJJJDHIGHGHFFFFFDDCEDDDDDDDDDDDDDCDDDD
@2AV
CTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAA
+
@@CFFFFFFFDHFIIGAFCHEGIIGIEIJJIIGGHAGEHAHGHEFFHIGIGDHHJEGGD=BDFDFD@9?CCCDDCDDCDDDC@@CDCCDBCDDCCCDCC
@2AW
GAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGG
+
@@@DFFDFHHFBHIJJJIIEEHIFJJJIJIJJIIJJIIEBBGGHGFHGEHIHGGGGICFH=@CACCECCDDBEDFCACAECDDCACDDDDDDDDDDBDDAD
@2AX
CTCTTTCTATAGTAATCATTTTTATAGATGTCTCTGGCGAGTCCAAAGTCTCCAATCTTCACTATCCGTGGACTGGTATAGTCTTTCACGGAAACAAGGC
+
@@@DDD?DDH?DAFFGGGIGIEI@HID>HCH@DHAE?FBGDDFHGDDCHGEHGIGG>DFCAGEHGGGGD@BEAE?E;?;B;;;@CCAC@BBBBBCCBCAB
@2AY
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
8?@DDDDDFFHHF<GC:CHEGGE>F<?<AAHD:@AG(?B9DB<8=CF=FADCCEEHH>?@>>ACCC(5>A@5;?ACCCACC>(,(:@:@(4:>@:C@CC:>
@2AZ
CTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATAC
+
@@@DDDBDFFDHHBHGI@AEAHEAEHIIDH@CFG9DHICCEGB?DCDGGDGHII=@BGHGIHHCEEHDC;@B7?A@A?3@>AC>@CC@CC?<A55>AACCC
@2B0
GGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTG
+
???DD;::C?@1C+2+2A3AA:F?EA:56:+(+333(++83>D>A>+8A332(+5((++3>3>3+444>4++4:::44>50)&53(+8>>A:3+4<>>:(:
@2B1
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
CCCFFFFFHHHHHJJJJJJIJJIJJJJJJJJIJJHIIJJJJIJJJJGGIGJJGHJGHHHHHHFFFFD>CEEEDDDCCDDDDDACDDDDDBDDDEDDDCCDD
@2B2
CTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJHJIJIJJIJJGHIJJJIJJJJJJJJJGJJJIJJJJJIIIHHHFFFF;AD?BD;@DDDDDDDDDDCDDABDB
@2B3
CTGCTAAAGGCTCCTTCCCTTGAGGAAGCACTCCACGACCCCCTGTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGC
+
CCCFFFFFHDHHHJIHJIIIJIGIGGIIJJJJIIJJIGIIJJGIJIIIEHGGGHIIJJFFGEHHHFFFFFDCDDDDDDDDDDCDEDDDDDCDDDCDDD
@2B4
TGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTG
+
??@D?;=:AA?DDBD3<AIIHID?DB<@<HBB?CE@<FDGFEGIE?FBBFB999?BGH8???F=CH@B@@@FHFA;)))7.?C37=@@3?@BEC:>CDD6
@2B5
TGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTG
+
???D7AD;BDDBDA2A<<BCDA;@D4E>B<@ED?)?CC?B@B<BDAD9B?4BD8=@@BCC>C487=).7=@CC>CD<3?@>@:7>:(.66;>>A3;;>==?
@2B6
TTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCAC
+
CCCFFFFDFFHHHJJJJJIJJJJJIJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJIJJJJJJJJJJIJJIJIJJJJGHGGEFFFF
@2B7
GCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGT
+
@@@FDFFDHF?FFIGGFHIIIJJIIBCEHJIHDHIIIIGDGHIEGHDGDHIIJJCHIDFHHIIIGJIJJIIIGHIHHHHGGFFFFDCDEECCCDDCACCCD
@2B8
GTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAAT
+
@@@DFFFFHAHFFHGIED?EFGEBEHGGCFHIIIIGIIIEIG?BH@GG?DGGHIDIIDHCAH>DCHD)7=A)==3=?7?@@>;>;;>CC5??@>A@ACCC@
@2B9
CTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACAAGGGTCAGTGGGATTGTAACAACCAGAAATATTCCAACTATAATAGTAAGTATGAA
+
CCCFFFFFHHHHGJJJJJJEIIJIJJJJJIJJIJIJJJIJJIIJJJIJHIIJHIJIJJJFIIJJJJJHHHFFFFFFFFEEEEECDDDDDDCCFDDDFEDE
@2BA
CCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGT
+
CCCFFFFFHHHHHJJCFEHIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHFFFDDDDDDEDDDDDDBDDDDEEDDDDDDDDD9
@2BB
TGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCT
+
CC@FFFFFHHHHHJJGHIIIJIIJJJJJJJJJJJJJJJJJIHIJHIJJJJJJJJHJHHHHHFFFFFEDEEEEDDDDDDDDD@CDDDDDDDDDDDDDDDDDD
@2BC
ACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGGG
+
@@@FFFFFHHHHHHIGGIJJIJJJJGGJJJJJHIIGGIDFGGIJGIJIGHHHHHEEFEEFCDA@BCDDDDDDDDD<BBDDDDDDDDCDDDDDDDCCDCDDD
@2BD
GGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCT
+
@@@FAEFEF;FFCCGHGEHHIHFBHIIIIEGDGGDHIIIIFHIB@FHGEHD@EFA?CDFEDDCCEECCC?AC>>ACCCCCDCCCCCCCCCCCADCCCCCC:
@2BE
CTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJIJJIJJJJJIJJIJJIJJJJJJJJJJJJJIJJJIIJJJIJJJJIJJIIJJJJJJJHHHHFEDDDEDDDDDDDDDD
@2BF
GACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAAT
+
CCCFFFFDHHHHHJCBHIJIIGIJJJIJJJIJGJJJGGIIJJJJI<DDCHJIJIJIHFHHGHIJIIJJIJEHHHHHHFFFFFCCCBDDDDDDDDCBBDD
@2BG
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
@@?ADDF?BFHHH@FBCECF<EFDBFBFC?9CGB@B3?FGGDGA@DHEECHC?9@A;F8F7=7@EGG>(=EEBDDF.;@B6@B?53<?>A@?>AB+8A:4+
@2BH
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATCGGAGGCCTGGGTGG
+
@@@ADDDAD><<CG<EA3::FH?DFBGHBGB11B:?@?BG@3D**BF@8=FFH;)..5CH>=).77?;7@>;6>;(.6(-((-55((,;?B<0+>@?7+)0
@2BI
CAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTT
+
@@@DFFFFHDDDDIIIBHIEIEHECHGBGGICDHIGGGIIGGGGII@GIIFGHIGIGHDGGIGBCCHGIGIIIIIHIGHHHHGFDFDECCEEDCC@CECCC
@2BJ
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTT
+
<@@FFFFFHFFHHIGIIAEHHIIIIGIIIIHIGIIIDBGGHEDDBGICHIEDGI@@FFCHIGI-=EE>CCEE>A;>?B=@?B<B?ACC@BCCCCCCCCCCC
@2BK
CCACGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGG
+
@@@DDDDDHHFFHIEGH:FHGI@DHGHIIGIFEGGGHIIIGIHIIGIII@ECHHHEEE;@ECCCCCEEEDCCCCCCCCCBCCBCCB<>CCCCCCCCCCDCB
@2BL
CCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTG
+
@CCFFFFFHHFHHJIJJIJIIJHGIJGJJIIJJJHJJGFIGGIIJJIBGGIJJJJ@DHGHGHHFHFFFFFDEEDDDDDDDDDDDCCDDDEDDDBDDDDDCB
@2BM
CTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAGCCATGGGGGTAC
+
@@<;?;DDBFHFDHB@F=BGB?:A;C@GHIAHHIEH?BD?F?D:DHIDGBAB7C;FC3=.7=ACEBDEE;;@@;>6;;>>>>>;>:::3>?5:@5<29)9A
@2BN
GTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTG
+
@BBFFFFFHHFHHGIJGIJCDHGIGDGHIJJIJIIIJJHEHFFF@DDDDDEEDDDDDDDCDACCCCDDDDCDDDDDDCCDBDBDDCCDDDDDDDDDBABD
@2BO
CACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCC
+
@CCFFFFFGGGFHGFEGIIJJJJIIHJJJJIJJJJIJGHJJJJIJJJEGIHHHIIJJJIJIIIGGIGIJIFHIIIIJJJHHHCCHFFFFFDFEEEDDDD
@2BP
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJGJJJJJJIJJFHIJJJJJJJJJJJJHH9>CDBDDDEDD@CDDBDDDDDDDDDDDDD
@2BQ
GGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTT
+
@@CDFDD?HFHHHHIIIJIJIIIEGGIJJIFIIJJJI8CCFHFHHJIJIGIGFFEEFDDDCDD?CDCDCCCCDDDDCC@BDDDCCD9?@BACBBBD@<?>C
@2BR
ACTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
CCCFFFDDHHHHHJJJJJJJJIJJJJJJJJJJJJJJHIJJJJJJJJJJIJIJJJIJJJJJIJIJJJCGIEHHHFGFFFFFFFEEECECEDDDDDDDDDD>B
@2BS
CGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGAC
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJIIJJJJJJJJIJJJJJJJJJJJJJJJJJIGJJHHHHFEDDBEDDDEDDDBDDD<>@DDDDDDD
@2BT
TTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTT
+
@<@FFFFFFDHHGIEFBHHIIDHCHCHGGHIIH@DHGHIGHGHIIEGGHGFGHHIGGIIIGEHEFGGIHIEHIG@DEHHFEEE:?>BCCEEEEE@ACFCEC
@2BU
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
@CCFDFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJHHHHHHFFDDEEDDDDCDEDDDDDDDDDDDDDDD
@2BV
TGGGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCT
+
@@@DDDADDACCFEEEI;F;F8?AFFEEGE@DFBFE4.=@A?BA8?;?===@6>>ABCABABBBBBBB=?B54:@:4++::3::<><599@<??483>3:
@2BW
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJJJIJJJJIJJJEIJJJIJJJJJJJJJJJJJJJJJJIIJJJJJJHHFHFFFFFDDEDDD@CCDDDDDEDECDDDDDDDDDDDD
@2BX
GGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGG
+
@CBFFFFFHCFHHJJJJJJJJJJJJJJJJJJJFHJJJJFHHIIJHIIJJIHHHHHFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDBDDDDDDDDDACABDD
@2BY
ATCCTTCAGCACCCCTGCTTGTCATGGGCACAACTCCATCTAATAAAGACCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAAT
+
1=1:4AD>++AC?EE7B>>+A<C<AFC+:9;)C?3***:9*:BBB?<?9))0*=8)/=).))/8;=)77@DA)=;?>3?@@A).37;;66;;55=;=:(;
@2BZ
CCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCT
+
@@@DFDFFHGGDDADFHIHGIIJIGFHIIGJIGIGGHECECEFEGGCDBFHIJIIGGGEEHI3@=7?EHEFFEEFFEEEC;==>CCD:;?BD@BDD?BC
@2C0
GCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATAT
+
C@CDFDDDHGHGHJJJJIIIIGIIIIJJGIHGEIIJIHGHIGIJIHGHHGHGDGHHFHFFFFFEECEDDDDDACCCDBBD@CD>>@CDCDDDEEECCDDDD
@2C1
GTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@@FFFDFHHHGGGGGGBDHGIIIJJIJJJJJGHIGIJJFIIJJJIJJICHGIIJGJHHHHCHFFF3;@BDDDD@@BDBD?CCCDDDCCCCCDDBDBBDDA
@2C2
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGT
+
=?1DDA:?DD<CDB=9@?@FEEIIIA<A>B>EE>@B:?91C><DD;BDEA@DDDD?DD5@CC)=7@47=@;A7AC@);??@>3,(;;?9;04>:(:9+3(
@2C3
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
<@@DB??DCB?+22ACFEHHEHEHGGCHA@C?CGHIGE0?D.B=BFBFG:5@E===A7AH=?D@;6;<B@BBCCCC>@ACCCCC@?CCA>>CCD@CCCCC
@2C4
CTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGAT
+
BCCFFFFDHHHHHJJJJJJJJJJJJJJJJJJJJBGIJJJJJJJJJJJJJJJJJJJJJHHHFFFFFDDDDDDDDDDACDDEDDDCDDDD
@2C5
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJHIJJJJJJJJJJJJIJJIJJJJJIJJJJJJJHHGHHFFFEEEEEEDDDD8?B@DDDDDDDDDDDDDDDDDDDD
@2C6
CCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
@<@DDDFFHDDHHIEFGEHIID@D:DHCDDDCHII@GGF9C9CC;8BHE;B@DC>A@;>C@@;?B?@CCCCCC:>@:@A>:@AB@ACCCCCB@B@CCCCCA
@2C7
GGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCA
+
CCCFFFFFHHHHHJJJJJJJIHIJJJJIJJJJJJJIJJJJIJJJJJJJIJJJIJJJJIIHHHHHHF
@2C8
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
BBCDDFFFHHGHHJJIJJGJJJJJJJJJIJJJGIHJJHIIJGGHJJHIJJIIJJJJJJIJJIHHHHFFFFFFDDDEDDCDDDDBDDDDCCCDCCCCDD
@2C9
CCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJEHIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIIIIJJJJJJJHHHHHHFFFFFFEEDEE
@2CA
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
CCCFFFDEHHHHHJJJJJJJIHJJJJJJJJJJJJJJIIJJJJJJJJJJIJJJJJJJJJJJJJJJJJCFGHHHGHFFFFFFFFEEEEEEDDDDDDDDDDD>B
@2CB
CTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGG
+
BCCFFFFFHHHAAAAFHIJJIJIJJJJJJJJJJJJJJJJJJJJJJIJIIJJJJJJJJHHHHHEHFFFFCDDDDDDDDDDDDDCDDDDEDDDDDDDDDEDDD
@2CC
GCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGT
+
CCCDDABDHDDHDIIHHDDGCB<AE@EBFFGEEGHD@CBGGGAHDCHGG<GEGHA?BA>GECEGHIG.;B=CEHC@@;@CFCDEEEACC>?BB?B@BB=95
@2CD
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
BC@DFFFFHHHHHJJJJGHIFHIJJJJJJJIIJIJIGJJJJJJJJJJJJJJIJIIJJJJJIIIJJJJIHHHFDDDDDDDDDDDCCDDEEEEDDDD@CDD
@2CE
CTGCAGGTTCTGGGAGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCACC
+
@C@DFFDDHDHHHFGIJEGHHGHHIFIHIJJIIIIIHIHJGIGG@FEAGHIJ>EGGHIHEEHFFBDFD?BD=BDDDC<2<ACD?@BD@&2?A?CD>ACDC
@2CF
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
CCCFFDEFHHHHHJJJJJJJFGIJJJJJJJJJJJIIJJJJJIJJJJJIJJJJJJIJIJIJJJIJJFHGGGHHCHHHFFFFFFFEDE@CDDDDDDDDDDB@B
@2CG
CCTCTAGGGACTCGAACAGAGACCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTC
+
CCCFFFFFGHHHHJJJJJJGHGHIHIJJJIJJJJIIJJ@GGIJJJJJIIIJJJIJJIIIJIIJH5?D?BDCCECBDD;?B;BDBDBBBBCDDDDDBBDDBD
@2CH
CGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGGTGGAGT
+
@@@DD>DD??FBFGF888):<??9CB?99:*:??BG6??DBFIC>B<BF@@GECGGGGGGHHAEB@?3?=AC?>B=?,55>CC@>9<><9>5<&8AB(<+
@2CI
TGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGAT
+
@@@DADDDDDDF?F@CCF@D?C9FCH>CHCHCHCHHIGABFHHIEGGDDFIIA<FF?GIG/9DFH>B=BBFC@==DG@;@;CCCABB??C>A@;A;@AC;5
@2CJ
ATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTG
+
@BCFFFFFHGHHHIJJIJJJIIJJDHJGGIIJGJGGIIJJJGGIIGHJIIIIICGFHIIIIGIJIJJJGIJIIHFBDDFFECDBBBDDDBDDDDDBBCDD
@2CK
GTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCT
+
BC@FFFFFFHGHHIJJJJJJIJHIJJJJJJI?FHIJJFFEHIJJIJJJJJIG?FGGGIIIGIIFABDDECDDDDDDEDDDDDBBDDD<BBBDDDDDDDDDD
@2CL
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHHHHHJJJJJJHIJJJJIJJJIGHIIJJJJJJIIIJBFHJJIJJJJJJJIJJJIJJHGIJHHFEFDFEDEECDDDDDDDD?CDDCDDD8ABD
@2CM
CCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTTCAGC
+
CCCFFFFFHHHHHJJJJGHJJIJJJJJJJJJJJJJJJJJIIIJJJJJJJJJJJJJJJIJJJJJJIJIIJIIJJGIIIJJIJHHHHHHFFCFFFDDDDDCDD
@2CN
GAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCC
+
@@@DFEFFHHHHHIHGHEHIBBHICGHIEFIIIDGGHB@GH<BFHGGIEIIGCE;FD=@CHBEHC@DHEGEEBB'=@B8ACDEDDCCBDAB@B?8?CCDDB
@2CO
TTTCTATAGTAGCTCGCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTTCTGGC
+
@C<FFEDFFFHBDHIIIIDEGBHIIIIIIIIIIIHIIGBHHGGHGHGHIGI@GGIGIGHHGHFFFFFDEEDCCB@D@BBDDDCDDDCDDBDBDDDEDDDDC
@2CP
GGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTG
+
@@BFFFFFHGHHHJJJJJIJJIJIIJJIJJJJJJJJJJJJIGHJIJIJJJJGHIJJJJ;AHHBCDBEFFECEDDDDDDDDDDDDDDCDDDDDDDDDDDDD
@2CQ
CCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTT
+
CCCFFFFFHHHHGJJJJHIJJJJJJJJJJJJJJJJJJJJGIJJIJJJJJJIJJJJIIIHGIIIJIGHHFFFFFDDEEEEEDDCCDDDCCDDDDDEEEEDDD
@2CR
TCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGT
+
CCCFFEFFHHHH@EGIHIJJJJJGIIJJJJJJJJIJJJJJJJJJJJJJJJJIJHHFHHHFFFFFEDDDEEDDDDDDEDDDDDDDDDDDDDDDDDDDDDACD
@2CS
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTT
+
CCCFFFFFHHHHGIJJJIIJJJJJJJIIIJIJJJJJJJJJJJIIJJIJJJIJJJHHHHIJJJJ-:EEAEDEEED>CDDBDDDBBBCDDDDDDDDDDDDDDD
@2CT
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
@@@@?DDA::?DDA:9EFEAIGIGHGCHC?9?G*1?DFEGHBB39?DG*??*?=CEEA>F@@>7C@;DDHHH<B9?96;(6;(;@=@C5>:;59,:@BCC<
@2CU
GTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGC
+
CCCFFFFFHHHHHJJIJJJJJJIJJJJJJIIJJJJJHIJIJJJIJIIIJIJJJJJJJJJJJJJJIJHHGIJJIJJJIIIJJHHHHHHHFFFFECEDEDDED
@2CV
CAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTGCTT
+
CCCFFFFFFFHHHJJIIJJJJJJJFHGIJHHJJJJIJJJIJJIJJJJJIJJJIJJJJJJJJJJJJIJGIIJIJJJJJJJJJHHHHHHHFFFFFFEEEEEEE
@2CW
GTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCT
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJIJJJJJJIJJJJJJJJJJJJJJJJJIIIJIIIJJJJIJJIJJHHF@DFFEEEEEEBDDDDDDDDDDDDDDDD
@2CX
CAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGAAAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAA
+
CCCFFFFFHHHHFIIIGIJIJJJJJJJJJJJIJIJIIHIIGIHIHJJJJGJIJJJJHGFFFFEEECEDDDDDDDDDDDDBBB(>CCDDDADDCDDDDDD
@2CY
CACCAGTTTGTTGAAATTGAACTTGTAGGTGAACCGTTTCCCCTTGGTCTTGTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGT
+
?@@?DB:BDFBFB42<AE4CEEFDDAHCDH<<+1:?C@DDDFEFEI999??<?<?B88)8B=F<BA@EF>?=7=.;7;;79>/3>6<@B855)5A>>BB?2
@2CZ
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGG
+
@@@?DDDDDFFFDFE@@EEH<?AB2:CBCCF>DFEEBFFFF@;B<FFB.8)=FFD@B(==DEA>?EBD@>B@@@CCBB>ABAB>@BB@>A@BBBBBBBB>9
@2D0
CTCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACT
+
CCCFFFFFHHHHHJIIJJJJIHHJJIJGGIIIJJIJJJJJGIJHIIIGIJJJJIHHAEHFFDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDD
@2D1
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHGJJJJJJJIJJJJJJJJJJJJJJJJJFHIIIJJJJIJJIJJJHHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEEDDDDDDD
@2D2
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJHIJJJJJIJJJHIJIIJJJJJJJJJFHIJIJJJJJJJJJIHHHHHHFFEFDDDDACCDDDDDDDDDDDDD
@2D3
TTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTG
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJJJJGJJIHHEIJIIJJIJJJGGGHHFFFFFFFEEEEDEDDDDDD
@2D4
ATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACAT
+
CCCFFFFFDDHHHIGIJJJIJIGHHHDGCCGGHGGIIIC@FGCHGIJIJJJJJJIJEGEGIFIEIJIJFGGHCHHEH7??BDEFECCCCEDDDCDDEDCDD
@2D5
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGATGATAGGAGGGTAGGAT
+
???DDABDDD8BDADEB@)++2<?F?<E9CD<DDCD99):?0?D***0**/**/)8.BC3==C8@@/-?<6?7?3>3(;>;>((((((-;>3,''+38((:
@2D6
TCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCC
+
CCCFFFFFHHHHHIHIJJJJJHIJJJJJJJJJJJJHIJIIJJJJJJJHHGIJIJJJJJJJJIJIJJJJJJHHHFDBBDDDDEDDDDDDDDDEDDDDDDDD
@2D7
AGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCT
+
?@@;BDDFDBDAFBBCA?BB)<FGHCFGGCGCGFGGHIIEHGIGFCHDG?DDCDHGHHGCEFE=@FCACAG@CE;CEEC@@BEFFEEEECCECBBCCC>C
@2D8
CCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGGGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCTTGCCAGCAAAGCAGTAGT
+
@<?DDFDAAFHGAHBGGIIHGGGDGHGAGHH9FHG';BBE??ECB;>B>BB6?7<?A?<CCCCCCCCCCC>CAC>AB8?@?C>@>CCCCCCCCCCCC:CCC
@2D9
CACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIIHFFFFFEEEEEEDFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDD
@2DA
CCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCA
+
CCCFFFFFHHHHHIIJJJJJJIIJJIIJJJJJJJJJJJJJJIJJIHHHEFFFEEEDDDDDDDBDDDDDDDCDEEEEEDDDDDCDDDDDDBDDDDDDDDD
@2DB
TCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTG
+
@@@FFDDBHHHHHGGGIGHHGGCFEHHGIJGGFGGIIGHIGGIIJJIH?BGEIDBDHIGFGEBFHIIDHIEHGICHGEGHFGHEEFFCEFFEDEEEEDDCC
@2DC
GCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCT
+
@@@DDDDDFDHHFEB>GEF<EGB@FHIIIGIIEHIEGIEHIIIIIIIHGGGGD9CCAEEEE<AB>ACCCCCCCC?CCCCC::@ACCCBCCCBCCCCCCCCC
@2DD
CTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATA
+
@CCFFFFDHHHHHJIJIGIIIJJJJJJJJJIIJJJJJJJIJJJJJJIJJIIIJJIIJIIIJIJ=FFHICDGIIIIJIJJJJJFEHFFHFFFFFFFEEEE
@2DE
GGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGG
+
CC@FFFEFFFFHDHI?FHGEHHHIJJ<BGIIIIIJJIJJIJJJFGJJIIGIIJGHHFHFFFFFECADECEDCACDCCDDEDDDDDDDCD@<<BBDDCDCAC
@2DF
CTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTC
+
CCCFFFFFHGHHHJJJJJIJJIJJJJJJFHIJJIIJJJJJJJJJJJJJFHHHHHBDFFFFFEEEEEEDDDDDDDCDDCDDDDDDDDDBDDCDECDDDD
@2DG
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTT
+
?@@DDFDFFDHHD>D@CGHGGGGGHG@HHIIGGGIE?GGGGIIFADBDGCDHGIGIIEHGIII@EB>CCCADED>@ABBDBDB@B>A@ABCCCCCCC3>AC
@2DH
GCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGGGCT
+
?<;DDD;+A<+2<<<EA?<<<3<C8C?E9*1111)110000000.@@556645@DA8;?@A36@==5>=55::<(>??9983<(+(2
@2DI
CGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJGJJJJJIJIJJJJJJJIJIJJJJIJJIIIJJJIAGHGBEFFEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDCD
@2DJ
CTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATT
+
:??DFEDDFGHHHIJGIJJGGIIIIGIFGGIGGGIBADDHIJGIIGHGIGIIIJIJFHJGDC@DHHHEEHFBCD;?B@BDCCCDDDDDDCCDCCCDBD<AC
@2DK
GTTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
@@CFFFFFHFHGHJIJIJIIJJJJJJJIGJJJIJFJIIHIIGJIJDEHGEGDHIG)7@;DHAECHFHEEDEBDDEE@A@9@@ACCCDCACCBDBACCDDD
@2DL
GCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTG
+
=1=DA?2=C?CFF9CABG:C:C<EFII@<@FA>F;39:?CD>BF*6)68./0BFEC@@C=FDA<C3=@DEIAEE;?;;BBD;;;@;>@;;>-(5<<9<5>9
@2DM
CCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGAC
+
CCCFFEDFHHHGHIJJIJIIJIIIIIIJJGJJJJJJJIJHGIIJFIJJJIIIJJJJJJIJJJJIJJJJJIJHFFF?BCCEDEDEDDCBDDD9@5<?CCCCD
@2DN
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJGHIJJIJJIJIJIJFFHIJJJJIJJJJJJJJJJIJIHIIHHHFBEEFEDEEDDDDDDDDD<CCDCDDD8
@2DO
TCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGAC
+
@C@FFFFDHHGFHJIJJJCHIJ>GHIIIEHGGIGEGIJIEHGIHGGDGHIHFHIGHHGCD=CFHIIIJGEHIDHFFCAHDFFDFFECEDEDDDDDCCCCD
@2DP
CGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CC@FFFFFHHGHHIGIJJHHHHIIJJJJJJJJHHIJJJIIIJIGJJIHHIHIJJIHJJIGHHHEFHHGFEFDEECDEE?ACD>CDD5:?BCCCD>BD2?C
@2DQ
CTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGT
+
CCCFFFFFHHHHHIJJJJHIJIJJIJJJJJJJGHJGHHIGIIJIJJJIJJJJIGJJJJIIJHHHHFFFDEECEDDDDDDDACDDDDDDDDDCDDDCDDDDB
@2DR
GAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTG
+
?:=D=DDDHD?HHHIEEGEHCAHH@CCFH<EFEBHFHGHG?CCDGIGD?DFDD<<BD99BGIE8BG8B88FFE)878@CEHIIHHCEE?B;>66@CC@;CC
@2DS
TGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTG
+
CCCFFFDDHGHHHIJCFIJJJJJJJIIHIJJJJJJIIJJJJIJIJBGIIJJIJJIIJJGGEGGHHFF?BDDDDBCCCDDDDCDDDDDDDDDDDDCDDDDDD
@2DT
GCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGC
+
?@@DBDDDFHFFAGEHE?EFHCHEGHGGA:@<BFEICCCEGCGGHBHC@;28??CCB@AAAA>CCCC@BCC@BAACCBBBBBBCCCCCCCCCCCCCACCCC
@2DU
CTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATC
+
CCCFFFFFHHHHHJJJJJJHJJJJJJJJJIJIIJJJJJIHIJJJJJJJJJJIJJJJJJIJJJJJJJJJJJJIIJJJHGHHHHFFFFFEEEEEEDDDDEEE
@2DV
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFDFHHHHHJJJJGHJJJJJJJJJJJJJJJJJJJIIJJJJIJJIJJJJJJJJJJHHHHHFFFABD@DDDDDDDDDDDDDDDDCDDDDDDDDDDDDDC
@2DW
GTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTC
+
CBCFFFFFHHHHHJIIJJJJJJJJJJJJJJJJJIJIJGIIJIIJGIJJJJJIJJJJJJJJJJJJJIIJIJJJJHHHHHFFFFEDEEDEDDDDDDDDDDDDD
@2DX
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
CCCFFEFFHHHHHJJJJJIJJJJJJJJJJJJIIJJJJJIIIJJJJIJJJJIJJJJJJJJJJJJJJJHHFFFDEEEECCDDDDDDDDDDDDDDDDDDDDDD
@2DY
CCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGC
+
CCCFFFFFHHHGHIJJGGIJJHIJIJGGIJJIJJEIHGIIJJJJIIJJIJIIIIIJGII=FHIIIJJGHHHHHHHDFFFFDDDDDDDDDCCCCCDDDDDDD
@2DZ
CATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACT
+
1??DD=,=AC<:<BAFD<?<?<C@<<?F:F?<E+9*??CFE*:C1?BF;B;DFB0(8?<<D:)888B>D=77@DD==7..6?E(;@7?B@3>6>>(-;A((
@2E0
CCAAGTAGACACAGCCTTTTGAAATATCTACACACAGGTCTACAAGGTCAACCAAGGTGAGTAAAGGACCATAAAACGTTGCCATCCGGGCTTTACGCAA
+
@@@DBAD;AABCB:CBGHBEDGH@C?FHIHDACE:D8D??D?B?FBB*000B@B8=B.=B=7=FHIIICCHAAA>AD8;A?B66@;?@@B=???>><@<5
@2E1
GCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHIJJJJJJJIIHIHHHHHHFFFFFDACCEEEDDDDDDEDEDDDDD
@2E2
CACGGAAACAAGGCAATTTCTAGCTGCCAGATCCCTGTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTACACACAGGTCTACA
+
CCCFFFFFHHGHHIJIIJJIJJJJJJIJJJJJJJJJIEGIJJJJJGIJJJJIHIJJJJJGJHICHIIIJGHHHHFFEFFBEEEDDDCCDDBBDDCDCCDD
@2E3
GACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
CCCFFFFFHHGHHJIJIJJJJJJJJJJJJJJHGHIJDHHJJJIIJJIJIJIJJHHHHHFFFFFFEEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDEDD
@2E4
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTT
+
<;;AABDBFA:@DE@C<ECB@?DA)??=0)B>DBFFIICF;F@EF@FEI@@D=?=ACA>BD<B@(;;(;;@B@>A@AA@>AAABB8<95<@AABBBB@44<
@2E5
GTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCA
+
@@<DDBFDHHADF<FAEBGBHAA>GEHGI;=GG<FDFGHAEHBGDGEDHGIIEEEFFD(;>BB??BBDD>A<CBD5<B<??B<?@CCCDEDDDA><A?>A
@2E6
TGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATT
+
C@@FFEDEADFAFG@9ACFEHHDHGEGEF<EA>HEHIIEDH>B@GGCHIGIIHIGEAEGI@F:<BD>FEHEC7=CCDEE3)=CEACCEHHF=;?CDC>>C@
@2E7
CCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTT
+
@CCFDFFFHHHHHJJJHIJIJIJJIIIJJJIIIGIIIJJJIIIJIIIGEHIIHGIIIJ<FHGIJGHFFHIGJEGGIIIGGHHGHFFFFFFEEEEEEDEDED
@2E8
CTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCGCGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTC
+
CC@FDDFFGGFHFIIGJGIFJIHGIIIFIJJIJHEGHIIHJIJJIIIJJIJIGGCGGHIIFDHIIHBEHFDCECECEDEEDCDDDD>CCCDEDAACDDCDC
@2E9
TTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCC
+
CCCFFFFFHHHHDHIJJJIGIFJIIJIHIIDHGIIJGJIJJJIIHCHIJJJJJJHGFGHIIIIJJJDFEGGHEHIBFHIEIEHAG>EHHHFEHBDFFFFF
@2EA
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
BCCFFFFDFHDFHGIIJJJJJIIIF9FGG?FHJ6BFHHGHEDHA(=@B@CHHIGIJIGHHEHHHFF>AACCEDBDC?5:@CACDDBBBCDDDDDDDDEEDC
@2EB
GTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATC
+
@@BFFFFFHGHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJIJIJIJJJIJJJJIHJJIJJJJJJJJIJJJJJIJHHHHFF@CEEEEEDEDDDDD
@2EC
CGTCGTTTCTTCCTTCTGCCCGTGACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGAC
+
@@?DFDFFHHGHHIJJIGIJJIJJJGGIIJEIIIIGGIIJIGBHGIIGIIJIGHHHHF@DFFACDD@BDCDC>CBD@ADDDDDDDDB>BCD>@CCDDDDBD
@2ED
GGAGCATTTGGGAGAGCCCCAGCTCACCCTTGGCCTGGCGTGGCTGTCCATCCACAAGGATCATTGCATCTGGCCCATGGGCCCTGAGGAACTTATTCAGG
+
CCCFFFFFHHHHHJJJHJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJJJIHHHHFFFFFFEDCDCDECDDDDDDDDDDDDDDDDDDDDDDDEEEDC
@2EE
GCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACT
+
@@@FFFDDHGHHHJJJJJIIJJIJIIIJIGIIGIJIJGIIJJJJJJJIJIJJJHDCGIIIIEHICHJEHCHGH@EEGEGIJHHHHFFFFDDEDDDDDDBDD
@2EF
CTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGG
+
CCCFFEDAFHHHGJIGIJGHJJJGGIJIIIJHIJIDGGJJJBHEHHEDDBDDDDDDDD@CDCCDDDDDDDD;@@BB9@@BBBDBBBD>C:?BDD5<<CD
@2EG
CCTCGATAACCATATGCCCACTCCAGTTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTA
+
@@CDDDFDHDFHFGGGGGGGGGGGHJCFIHBHIGHGFDDEGCADFCGHFHGIIGHGEG@FHG@HDDEACECEE?CHCEDFCCCDB@B@CCCDC@@CC?:;
@2EH
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJGHIHIJJJJJJJJJJJJJJHHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDEEEEDDDDDDDDD
@2EI
TGGCTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGC
+
C@CFFDFFFFHDDFGCBFCHDHHIIIEEHHIIAGGIHIGIIIIIIIIIIIGGEHHGGFHHGEHGEGHGEFCDBDDDCDCDD:A@+>@CDCCCD>CCA??BB
@2EJ
CTTGGAGGAGCCGACAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCTCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGGGGACG
+
?<?DD8B2+A?D1))<@CE9*:?*?D3:C9BD*:B*?<D)*??B<B44=CCECC=A))=))).7=AA6(.)6(;63;'3(,,(5(5(:558>5(4(2&+)0
@2EK
AGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTGTGCATATCCTTGAGTGGGCTGGGCGG
+
<@@DDDDDAFFFFIIBF;FEIIEFCFGIDF?<3CBGFI*?DFDEEB@?FCF?DFEF8<=F@F:87@CF'=;;BBB3>@ABA@B@@BBABA>BB?<@BBBBB
@2EL
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
7@@DDDDDDH>F?@FA?EGC6:C@91?F9?CD<*:DB?G=@DGDA6?F)/=2@F@GCAACA;)=>>E>;?<A(;(5;;>(;A:>>::A@A>:>>3?>>:
@2EM
CACCTCTTCCTAAGAATAAAGGATTCCCCAGATGCCAAGGTATGGACCAGAATATACATCCGAAAGCATGACTAATAAGCTTCTTAGCCAATGCCCTAGCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJHHIJJJJJJJJJIJJJJJIJJIJJJIJJHHHHHHFFFFFFEEEEEEEDDDDDDDDDDDCDD
@2EN
CTCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCC
+
CCCFFFFFHHHHHJIJJJJJJIJJJIJJJJGIIIIJEGHIIIJJHJJJJJIJJJJIIGGIJJJJJJJIIIJIHHHHHHFFFFFEDDDDDDDCDDDDDDDDD
@2EO
GTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGC
+
???DD;DDDB<<<E2A42AE@EEEAE<:3+AFBEEE?0?89?DD<8D9/B===88@=7ACEICDAA?7).7;;A=(=?AAAAD;3;A?((,9:;A:,9<>
@2EP
GGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTT
+
?@@DDDA?CF:+AEB1@F@@DFFFA4C==@)/)7>7CC;BADBB@D;AD;>@@53-5;A;:558'53832259@>88(+((+98???2?<8550503?(+4
@2EQ
GTCCCGATGAACGAGCTTCATCTCGGCCAGATACTGCATCCCCTGTGAGATCTGCCAGGCAAATGAGATGAGGTCGCCCATGGTGAGGGCCCGCTCATCCG
+
@CBFFFFFHHHHHIEIJJJIJJIIIGGIJJJIJJJIGGIJJIJIIEGEEFGGIIIJCGGJHHHGHBBBDFDEC>CBBDDDCDD:@>ADDDDDDDDD>ACCB
@2ER
TGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
@CCFFDDEFHHHDGGGIJIIAHHIFHIGIGIJIIIFHIIIIGHEGHGGGIFGIJJJJDGIIJGGGIGIIIGEDHFFCHHFBDD<ACDCDCDDDDCDEDC
@2ES
GGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTT
+
CCCFFDFFGHHHHHIIIJIIJJIIGHJIJJGJJJJJGIJGJJHGGIJJIGGFEHIJHGIJGGIIJGIHABDFDFEEECDEDDDDDDDDDDDDDDDEEEEDD
@2ET
TGGGCCTAGATCAAGATCTGGTCCTTCATCCATGGGTCCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCT
+
@@@FFFFFHFHHHJJIJIJJJFHHIHIHIJJIJJJIJGJIJJJJJIIJIJJJBHGIJJAHIHHBBCC;@DBDCCCCDDDDDDCDD?CDDDDDDDDDDDDDB
@2EU
CACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGC
+
@@@DDDDDHHDHBHBC?BFHFHAHEEHEHGEGEEHEGGHHIIGGIHCHD@?FG??BF>G8BFHGGHIHGGHIAHECG;A5=>B;?@?@;A@CCC>@B;AC
@2EV
CTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
@@@DDFFFGHHHHIIJIIIIIIJJJJIJJJJJJJGIJJIGHHGIIIIIJJJGIGIIJGDGGHIIAGECHHHFFFEFEEEECCB@,;?D9CCDDDC:ABD
@2EW
CCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCAAT
+
CCCFFFFFHHHHHIJJJJJJIJJIJIJJJJIJJJJIJJIJJJJJJJIIJJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJIIJJJJIIIIIHHHHHHFFFFF
@2EX
CTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCT
+
CCCFFFFFHHHHFIJJJJJJJJIJJJJIIIIJJJJJJJ8DHHIIJJJJJGIJJJJIIIIHFGFFFFEDDDDDDDDDDDDD<CCDEDDDDDDDDDDDEDEDC
@2EY
CACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGG
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJIIJJJJJJJJJHIJJJJIJIJJJIIJIJIIIIJJJIIIJIHHHHHFFFFFEEDEEDEDDDDDDDDDDDDDDDD
@2EZ
CTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCT
+
CCCFFFFFHHGHHJJIJJIJJJJJJEJJJIJJJJJJIIIEIIIJJIJJGIJJJIGHIGJIIIIJHEHIJGHIJEGIIGIHGGHHGEHFFFFFEEECE@CCD
@2F0
CTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACT
+
@@@DDDDEHDFHFIIIEBFHIIBHHEHEHBGICGDHHHIGIIIIIIIIDGBEDFHIGGIIHIIGHA.=@DCEG@EE@E7A?EEEDFDFFFCCECEEEDDC
@2F1
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJHHHIJJJIJJIJIJHIJJJJIJIJJJJJJJJJJJJJJIIJHHHEFFFFEEEEEDDDDDDD?CDDDDDD8?@DCD
@2F2
TTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCT
+
@CCFFDFDFHFHHGHIJJIJJIJJJJIJIJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJIJIJJJIGJJIIJGIJJJJHHJIJIJJHGHHGHGFFFF
@2F3
GTTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGC
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJIHHHHHHFFFF=@D?CDDCDDDDDDDDDDDDDDDDDDDDDDDDDD
@2F4
GTCCAAAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@@@DD+=2AAC?<CC@G:3<<AFG@GI4??CF@B<DG@:090999?B<D?F@F<8CCB87.=7/.5;/5?.?77>.>@>;;;>BBA?5>A?5,8>2++8(4
@2F5
GCCTGCTTGGTCACACCCAGCCCAGAAGACGGGTCCTCCAGTTCCAGTGACTCTTTCGGTGGAGCGTCAGTGGGCTTTTGCTCCAAGGAGTGCCTGCTCAT
+
BBCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJHJJJJJJIJJJJJJHHJJIJJJJJJJHHHFFFDDDDDCDDDDDDDDDDDDDDDDDDDCBDDDDDDDDD
@2F6
CAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJHHHHHGFFFFFEEEEEEDEEEFDDDDDDDCDCDDDDDDDDDDDDDCDDCDDDDDDDDDDDDDDD
@2F7
TGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCT
+
CCCFFFDFHHHHHJJJJJJJJJJJJJJJJJJJGIJJJJJJJJIJJHHIJIJIJJJJJJJIIHIIJIIIJJJJJIJIIHJHHEHHHFFFFFFFEEEEEEEDD
@2F8
GTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGAC
+
@@@DFFFFGHGDFIIJJJJICGIHHEHHGIIBEHGIGIIIIC@FIGGJFADGHIFHIHIIJGIIIGEHHAGHJIJJJJJHEHHFEFFFFFFEDEECCC
@2F9
GTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJIIIJJJIJJJJJJJJJJIJHFFDDEDDD?ADDDDDDDDDDDDDDDDEDD
@2FA
CTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGC
+
@@@DBDFFHGHFHFIJIJIGHHGIGGHGHG>CC>EEGIJIGIJIJJJGBG>DHHGFAADAAC@E>CEDB;?DA@@CEEEDDDCDCDDDDDCDDDDDDCDD
@2FB
CTAGCTGCCAGATCCCTGTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTACACACAGGTCTACAAGGTCAACCAAGGTGAGTA
+
??;DBDADFDBDAAHDHEHHGHHIIICD@+CHCEGHGGHECC:BG@FHFHDHGIHDFBFHGGEIAGHCFA>5CA;7==B7?DDB6@CC@=?BB=::>A:;
@2FC
CTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAAAATGCTCCCCAATAAGG
+
CCCFFFFF?FFHHGIIIIIIJEFHIIGIFIGFIIIJJEGIGJJIJJJJICHHHJEFGIJIIGGGIJJGGAF@GCEHIHHHGEFFFFFFEEECCBDDDDDDC
@2FD
CCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCT
+
@@@DDDDDDFFHFGHIIIIG@:CEEAHEE>BFBFCGIIGBHBAHCHHEGIEFHGBGHGEHFBHGGEH<@GEGIAFGG==D?AHECEEDEEBC@@ACC@B@C
@2FE
CGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTC
+
@@@FFDFFGHHHFHIIGHIIIJIFIJGGIHGIGHGJJIIGGGIEHGGGGCEEFHIIEHHIGJIIGIBGGGGEHIIEGCGFHFAEHEFEDFFFEEECCEEE@
@2FF
GCTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCT
+
BBCFFFFFGHHHHJIJJJJJJJJIIIJJJJJJJJIJJJJJGJJJJJJJJJJJHHGFFDDEDDDDDDDDDDDDDDDDDDDD8?BDDDDEDDDDDDDDDDDDD
@2FG
CTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGC
+
CCCFFFFFGHHHHJIJJIJJJJJJJJIIJJJJJJJJJHIJIIJJJJJIIJIJJJIJJJJJJJHHHHHHHFFFFFDDBDDDCCDDDCDDDDDDDDDDDDDDD
@2FH
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATAT
+
CCCDDEFDFHFHHIIIIIJDHHIJGIJJJJIJIIIJJJGGIJJGGIIJJJIIIIIIHHGIGHIHJIHHIFHHHFDFFFEEEACEDDDCCCDDB@CCDCCCD
@2FI
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
CCCFFDFFHHHHFIJJIIJFIIJJJJJJJJIJJJJJJJJJJGIJJJIIIIIIJGGHHIJIJJJJJHIGIGHHF5?ACEDEDDDD;<CCDCCDDDDDDDDB
@2FJ
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGGGGTAACTAGTGGGAGGC
+
@:;DDDA?FHF>ABA2:<3:AEF@C??GH@AGCGIEG<BFGADF<?4BD<?DCGG<=3@@@CDCG.7?;;?>7?7.;;@CC@'59@5>?ACAC4><<885?
@2FK
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
???=D?ADF?B<CEGCGGF:<C<FB)??BGFEEFFEGEFBF98?@FDEABFC;CFIFIF;A=)=;BB77)7?@;;>>>>A<;?BBB3>3>>8854812959
@2FL
CTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCTTCTTCTGTC
+
@@@DDDDDABFHHGEHGGEGIC?1?;@?4B<?;BDF??FAG87==@@CG7=CE3====?B6>@CA?CBBBA@C<:>?C:AA9@9<BBAC>9ACCCC>@CEC
@2FM
CCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCC
+
CC@FFFFEHHHHHIJJIJJJJJIJJJIIJJJJJJJIJGFHHHHIJJJJJJFIJIIJEHIJGGGGIJEHIJGHGHIIIIGHHHHEHFFFFFFFDEDEEDACC
@2FN
CTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTT
+
@@CDADDDFFHAHGGGIIIHIEGGHGIEHGGIAFHDGHIB>BG@?<CEDDCEDDECC@?B;;??C@?CC:@ACC>@@C>CC:4::@C>CACCCCDCECDEE
@2FO
GTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGC
+
CCCFFFFFHHHHHJJJJJJJHJJJJJIJIIIIIIJJJFHGIIJJIIIIHIHIGFGIGJJJJICEGHHG=AHFFFFFDDEEEDEEDDDDDDDDDDDCACDD
@2FP
AGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCC
+
@C@FFFFFHHHHFIJJJIJGGIGHIHIJGIIIJHHBGHHIIIJJJFIGIGIJJIEGIIIIHIJJJJJIJJJIIEGGIGGIE?EHHHFFFFFFCEEDEEDDD
@2FQ
GTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTC
+
CBCFFFFFGGHGHFIIIIIIIIJJIJJFIJIIIJJJJJIGIJGIJJJJGGIIHIJJIIJJJIIJIJJFIHFEHFDDDFFAACDDDDDDDBBDDDDDDEE
@2FR
TATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGA
+
@@@DADBDDHDDFHBGGIIBBAA?FEG?F?BBD:BFCBF>DEEHEHGFF<CG>)=@@C@@6;AA?AEECDDBDE=?A.;AC55;(,8(9?CCCCCCCCA
@2FS
TTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGA
+
CCCFDDEFHHGGHJJJJJJJGIJJJIIJJIJGHIJJJJJJJDHIJJIJJIJJJJJJJICFAHIIJIIJIJICEGIJJJIJIJIGGHFCDEFFFFFECCEC
@2FT
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGAT
+
BCCFFFFFHHHHHJJJJJJJJIJ@FHFHJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFFEEDEEEDDDDDCEEFEDDCDDDCCDDDDDDDDDDDDDD
@2FU
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
CCCFFFFFGHHHGJIGIJJJJICHIIJJJJJIGFGCGIIJJJ?DHGGHJJJEH@DEHEHGFFFFCCEDDDDDDCCACCCCCDDDCCDCC@CDDCDDDDDDC
@2FV
AGACTGCTGAAAGTTCATTTCTTGCTCCTTGAATATGTTTAATTTCTACAAAGCTTCCAGTTGTGCCCGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCC
+
CCCFFFFFHHHHHHIJIJJJJJJIJJJJIJJJJJJJJHIIJJJJJJJJJJJJJIJJJJJJJJJGIHIJJFGIJJIJJHHHFHHCCEFFFEEEEEEDDDDDD
@2FW
CTGTACTTGCTCTCCGGGGCCCCAGGGCGCCGGCCCAGCATGGGCAGTTGCTCATTGTTGGAGATAAGGTCGCGCTGGTCATCCGTGACTGGCTTCTGATC
+
BCCDFFFFHGHHHJJJJJJJJJJJJJJJJJJJJHHFFDEDEEDDDDDDDDDDDDDEDDDDDDDDDDDDD@CBBBDDDDCCDDDDDB@BDDCDDDDDDDEED
@2FX
GCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
CC@FFDFFHHHDHEDDHHIID@3@CCDDACCCC>CDEEDDDD8CCB?BD@DBACCCDCDDDDCDDDCCDDDDABB@BDDDDDCDDDC>@?BCC@ACC@AC
@2FY
GTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAAT
+
CCCFFFFFHHHHHJGHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIIJJJJJJJJJJJJJJHHHHHHFFFFDDDDDDDDDD
@2FZ
TGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGC
+
@@@?DEFDHFBFHEG?FDGGGIG<FHCHIB1?FDGGIGGHGCBGGHGG;DEDEEEEHFFBB>CCCCEEDDDDCDCDD@CDDECC>CCCC@CCCCCDDC@C<
@2G0
AAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCG
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIDDDDCDDDDDCCDDDDEEDDDDDDDDBDDDDDDDDDEDDDDDDACDDDEDDDDD
@2G1
GGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGAC
+
CCCFFFFFHHHGHJJJJIJJJJJJIJJJJJJJJJIJJHI=CHFHHFIIIJIIJJJHHEHHHFFDFDEDDDCDCCDDCDDDDECDDEDDEDDDDDDDD@BDD
@2G2
CCTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGG
+
CCCFFFFFHGHHHIJJJJIGEHHIIJIGIJJIJIJIIJJJHIIJJIIIJIJJFIIIFHIHHHHFFFFEFEECDDDDDDDDDDDDDDDDDCDDDDD>CCBD
@2G3
GTTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATC
+
@=?BDDDD:CDFB@DFA@EHHIGHGEHBFHEG?@CFHIGGIII?BGGG?D>FHIGIIGIIGGGHGGIGGEEHIFDC@E=CEEHF=BD>CDCACCCCC@
@2G4
ATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGT
+
BCCDFFFFHGHHHJJJJHJJIIJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJHHHHHHFFDDDDDDDDDDDCDDDDDDDDDDDBDDDDDDDDDDD8
@2G5
CCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCAC
+
CCCFFFFDHHHHGIJIIGIECHIJJIJII@EFHIJJGIJJIIJIJJJIGGGIIGIIGHFFFFFFCEEEEEDDDDDCDECDEDDDDDDDDCDEEEDDCDDD
@2G6
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
@@@DDDDFGBHH<DGHFHHGHIJGIIEHIDGA?CGCHBBFGIEEHIIIIGBGGBFHGB;CF@=@GHIGCEH9ACD8ACCDDDAA?B<BB?BDBCCCABDC
@2G7
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@@DDDDDB?ACDE@EGH>BH9<FHDBH:CD@A>FHHHDIEHHICDDF@GAGGDHGEF=B=BCC@A>:@CCCCCC?ACC>ADCAA@@C4>:9ABCC?CCBB
@2G8
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJIJJIIJIJJIIIJJJIJHHFHHHGFFFFFFEEEEEDEDDDDDDDDDDDC
@2G9
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJHIJJJJJIJJJJJJJIIJHHHHFFFDDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDD
@2GA
GTAGCTCTTCTGGATGACCCTTCAAATTCTCATTTTATTGCCTGGACTGGTCGAGGCATGGAATTTAAACTGATTGAGCCTGAAGAGGTGGCCCGACGTTG
+
CCCFFFFFHHHHHIIIJJJJJJJJJJJJJJIIIJJJJJJJJJJJJJIIJJHIJJIJJIJIJHGIJJJHHGHHHFFFFFFEDEEECDDDCDDDDDDDDDDDD
@2GB
CTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCA
+
CCCFFFFFHHHHHJJJJIJJIJJIJJJJJJIJIJJJJJJJIJIJJJIJIHGEIIHIGIJIJFHIJJJIJIIJJJJJJIIHHFHHGFDFFFFFEEECEE
@2GC
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
@@@FFFFFHHGFHJJIJIHIIHIJJIGIIEHIGHHGIIDGHIIFHIIJJGJIIJJIJJIJIHFFFHFEEFDEEDECCCCBDBDABCCDDDCCCDCDACBDD
@2GD
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
?@@??4D?DF??BF??<AFD<F@?CFA@*9)CG<3:1?B9:?BG*BFD-=BG3=@FGHG-677)7?;?)76?C;?CC@BB=,3535558<:?+4@C4:<85
@2GE
CACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTT
+
CCCFFDD?FDFDFHIIIIIIIIIIIIIGHGIFHGGGGIIIIIIIGGIIIIIIIIIIHIIEIIIIGHGIEHEGIECHHHHHHGHHFFFFFDECAECEB?ABD
@2GF
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@C@FFFFFHGGHHJIIJIIIEIJJJFHIJHHJIIGIIIGIIEGJJGJJIJIJJJJIIIEHIHFFGFFCFFCCDEBB@>ACACCDDCDACDDCCDCCCD9:
@2GG
CTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCA
+
BCCFFFFFHHHHHJIJJJJHIJJJJJJJEHIIIJJIIJIJIJJJIIJIHGIFIIIJIIJJJJJGHIIJJGJJJJIJJIJEHHEHHFFFFFFFEEEEEEED
@2GH
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCT
+
@@@DB=?BF=DFDGDBF?FGFEIFIG@CFIEE>BFEFEGI@B?F;FDF@BEIEFEFEE-:<,;;@CCBBB>@(:@A>BA5,:@>A8805<?BA>ABBB@AB
@2GI
CGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCC
+
CC@FADEFGHHHHDBFHEIIGEHHGGHIBFBHGGGGHAHHIIIHIIIEHGIEHHEGHG==@FHGGEIGGIGICCCE>>BF>CDDBCCCDDDA>AACCDCDD
@2GJ
CTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTT
+
@@@BDDDDDHFHDFFHBFDHGIIGHGFHGIGGIIEGHIIHIHGGIEH=FGHIII;CEGC=?EHEHDC;@EECCCACCB?C>?ACC;;>@CCCCDD3:>CCC
@2GK
GCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCT
+
@@@FDD?DHBDHHGIGHIHEHHGC>EHIADCHEBFECDCFDEFAAHIGIIIFHHIIBDCE?D7F=C=F@CGIEGGG;CE77;BD?.=AA>>A;>;;:>@?>
@2GL
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTT
+
@?@DB<D=C?>FHBF<E>HD<B<<EG<?4F4?EFH@993CG@B>GHHHCE<?8/?D=BFGIII':B<3;;@C>C(>ABB?;<2<83:@<<49?C@CCC::>
@2GM
GTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCC
+
CCCFFFFFHGHHHEGIJJHHIJEHIJJIJJJJJJJJJIIJJJJJIJJJJIJJIJJJJJJIJGHGHFFDF>AEEEEDCEDDDCBCDCCDCCDDDDDDDDDDD
@2GN
CCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTT
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJJJIJIJJJJIJJJJJJIHHHFFFFFEEEEEEEDDDCEEEDDDDDDDEEEEDDD
@2GO
GTACACTGCAGGTGGGTGGTCAGCTGCAACATGGCCTGGCAGCCTGGCCCTTGAAGCACTAAACTCTATTTCTCTTTCAGGATTCAGATCATGATCCCAC
+
CCCFFFFFHHHHHIJJHIJJIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIHHHHHFFFFFFEEEEEEEEDDDDDDDDDDDDDDDDDDDDDDDD
@2GP
ATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTG
+
CCCFFFFFHGGHHJJJJJFHIGIIIIJJJJJIIIIIIHHIIHIIGHIIJJEHIIEGHIJJJJIGGJGGICHGGIHHHHHEDEFFFFEEEEFCEDBDCDDDD
@2GQ
GGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTG
+
@<@DFFFFDFHCDFEBEHFHIGG@FEEHGBH>F9CBE:<DGA9BFE@FAFBE=FCGBHB-;7@@CEECCCBBABCCC5<>CCCCCC?B<<5CACAC>@@
@2GR
CTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTT
+
@CCFDDFFHGFHHJJJDGGHHHGGCHGIEIJJIFHGHIIJHIIJJGIIJJJFJHJEGHHDGHIIIGGIEACFAG@EA@EGGHHHHHHFFFDCEEDC@CDCD
@2GS
TAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
@@@DDFFDFHFHGDIGIJGIIIEHGIJGIEHIBGEIIGHIGHIGGIHGEGGJIDGE>EHHF;;?@;@CEEBB@;;>AC:>CA<ACDDC@CDB?C>BCCDD
@2GT
CCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCT
+
CCCFFFFFHHHHHJJJIIJJJJJJJJJIJIIJJJIIIJJJIJJJJIJJJJJHHFFFFFFEDACCDDDDDDDDDCDDDDCDDDDDDDD@AACDBD9BBBDDD
@2GU
GTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTT
+
@?@DDADBA<CA<?CBEEH@HGG>HBHHGEAHH>9FHEHE@GCGGGG>B19?FEGC?FCG==@FFAHHD@EGI>DCAEHFHCD9>3;;;@AC:A;ACCCCC
@2GV
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CCCFFFDDHHHFFIIHIGHIIIGIJGIJJIGIIJIEIIIJGIJEHGIJIBHHGGGIJJJIHFCCHFDEEFFFDEDCEECDDDCCDCCACDC@@DCBDD3<B
@2GW
GCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGG
+
@@@FFFDDFDFHHEGGGGGIG@EGGHHGGGEHICFHIEGGGHHGGIIIDHIIGGIIAGI5AEEEFDFBC>ABCCCCCCC>A?=@8@3>?AABB@9>CCCCB
@2GX
GTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGG
+
CCCFFFFFHHHFFIIIJBHIIIIGIIJIGEHCHGIIJJJIJJJIJJJJIJJIJJJIIIGIJGGJJJJEHIIJFIHHHHHHH@DBDDFEEEEEC@C@CCDDD
@2GY
ATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTT
+
@@CFFFABCFHFFICFHDGIIIEFFGHID@FDFGIGHGHFHIIIGEFHIIIIIIIHHGGHHHFFDD@CEEEEEEDEDEDDDDDCDDDB
@2GZ
GAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTC
+
@@@DDEFFHGHHHJJGGIJJJJJJCGIIJJJJEEHDHHDHIJJIJIJEIEGIGHGHHHFFFFDEECEDEDCCCDDDBBBDDDDDBDDCCCDDDCDDDDDC>
@2H0
TGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
CCCFFFFFHHHHHIJJJJJJIJIJIJJJJJJJJJJJJFIHIFHJJ?FGIHJHJIJJ@EHHHHHHHFFFFFDDDEEDDD;@DDDDDDDDDCCDDDDDDDDD
@2H1
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGC
+
C@@DFFFBBDDABCDDC3>C>CDEDDDDDACDDABDDBDDC>CDA@CCCCACDDCCCCCAB@;@@CCCA>>CCCACC<CD4@>A@A?@CCD?BDB(:4>CD
@2H2
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
CCCFFFFFHHHHHJJJFIIIJJJJJJJIJJFHIJJJJJJJJJJJJJIJIIIIJIJJJJJHIHIJGHIHFHHHFFFF@CED@CBD5>?BCDDDDDD<ACDDC
@2H3
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
@CCFFFDDFDHFDIJJGIJJCHHIJJIIIJIIJIGIJJJJIIIGIJJJIBFBDGGHIIIGGGHIII=DHI>EEF,;AA@CEDCDD5<CCCACCDDDBD?B?
@2H4
CTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTT
+
CCCDF;DFDHHHHIIIIIIIIIIIIIII?GHIEGHGHIGGII@HHGIIEGIIIIIHHHEHHGDBFFECFCCCBBBB8?CCCAC99AB9ACCCDCCCCCCCC
@2H5
TCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTG
+
CCCFFFEFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJIJJJJJJJJJJJJJJH=CHHFFEFFFEEDEDDDDEDEFDDDDDDDDDDED
@2H6
ATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCT
+
<@@DDDDDFDBDFHH=EEGIIGIE<AEAE1?FGHGGG>FHIIGGHEHGGHG2==@CCGI>EH@EH<?BCEEEA>@CCC@=?>ACCCCCCCCCB(:A>C:@C
@2H7
TCCTTGGTCGGGCTGAGGTTGTAGCACTCGGCCAGGAAGACCTTTCCAAAGGCTCCCTCACCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTG
+
???D?A3DDC0<8<E?CEF@?111?C??D66B??D;88..88B@=8CEAEIC=7=5-.766@>>@;A;>>(55=;>>3:93&+224::AAA:<4>AEA:BD
@2H8
CGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGTACCTCCTTC
+
BC@FFFFFFFHHGJJJJIIIJJJJIIJJJJJJJHIJJIJJIIIJJJIGGFHFFFGFFFFFCADDEDDDDDACDDBDDBBDDDDDDD<ACD:@CDDDDDDC
@2H9
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@@@FFFEFHHGHDHHIIJGHIJEGHIGEIHHGGGIGHIGJJFHIIEGIJIIGEHHHGEHBEEFFCEEEEEDDDDDDDDCDDDEDDCCACCCDDDDBBDCCD
@2HA
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGATCTTGTAGGTGC
+
?=?DFBBEHBDFHFI>GEFEEGIGGCFCHIIIGIIGBBBFFHIG?FHI>DC=C@FFGEI@AHGGICAACCEEBBDCCC@>>;AC>@',8ACCCCCC:@>
@2HB
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGT
+
CCCFFFFFHHHHHJIJJJJIJJJJJIJIJJJJJJJJJJJJJJJJJIIJJJJJJJJJJDDBDDDDDDDCCDDEDEEDDDDCDDDADDDDDDDDDEDDCCDDC
@2HC
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTT
+
CCCFFDFFHHHHHJJJJJJJJJJIJJHIJJJJJJJJJJJJJJJJJIJJIHFFDEEEEEDDDDDD>CBBDCDDDDEEEDDDDDDDCCD@BDACDDDDDDDDD
@2HD
CTGAAGTCCTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCT
+
@<@DDDEDHFFHDGEGIEAGID7BC;AFHHEHGICEAB?DB?F@BGEHIIIGGGIIGCEACHCBCD>;BCCECCACCCCB>A?ACDCCCCCCCCCCBBBB?
@2HE
ATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCCAAGTCG
+
?<@D7DDDFFDDD<@C@C:FDAFCH<AFHHECHI<?CFG<FDEGICG/8B)=CF)8;F@GHA?>AC@@?(9A;;CCBC:;8=<<C>CAB39?A((9:(48
@2HF
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
@@@BDDDDHDFHDGGIHIIFHIJJJIIJGJJIJDHIJIIGGJICB>FA7DGHIEGIJCCHGGEGEHHHFHFFFFBDCECDDDDCDDCCBDDDEDDDDDDCB
@2HG
CCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATA
+
@@@ABDBDFDB<DDDBEGIA?<FAEDH<AA3?GHIIEC9?FH@?8?:8??DDDGGDBF;=@EE:DEEHH>@5666@>@>AC:AB8=<<?AA>A::4:>>A
@2HH
AGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGGGGGGACCCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJHGIJJIJJIIIJJJJ@FHIHJIEGIIJJJJIJHHHHFDCDDCEEDDDD>CABDDDCDDCCADDBBBD-009<(2&
@2HI
CTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGT
+
@@CFFFFFHHHHHEGCFFHIJIIIJJIIIFEIIGFDGIIGHHIIJIIGECHGHIJHIGEFDD@BDDDCDDCDDEDDB?>><9<ADD<89BBDDDCDCDED@
@2HJ
GAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCT
+
CCCDFFFFHHHHGIIIJIJGIHIIIIIJIGGHIIGIDGGHIIIJBHGJJJJJJIIIIGIIJIIIEBAHIDECACCBBB,;BB;CCCCCAA@<BDD@BDBDD
@2HK
AGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATG
+
<?@DDDDAA?AADAAGEA:F?@@?:BBED8CC@F4CCDD@8FG@DB4BFGB@FFDBDHIGGB@@@@EHHCA=BECC3>>;@CCACDCCC@A>>BBC@CCD4
@2HL
GGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIIJJJJJJJJJJJFHHHHFFFFFFFEEEEEDDDDDDDDDDEFDDD
@2HM
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCC
+
@C@FDFDBFHHHHJJIIIIGHHIJIJJIJIGHGIJJFGFHIGIJJGIFGDGHIBFFGAHG@-=@ECEHGEFF;?CCDCCDDDDBDDD@CCDDDDBBDCDDD
@2HN
AGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTT
+
@@@FFFFFHHHHHGHGGIIJJJJJJJGJJJJJIGGIFIJJJJJJJJIJHHIJJJIJIJIJBHHFFFFFDEEEDDDDDDDDDDCDDDDDDDDDCDBDDDDDD
@2HO
CAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTG
+
CCCFFFFFHHHHGJIHIJIHIJJJJJIJJJJJJJJJJJJJJJIJGFHHIJJJJJJJJIIGIHGHJIIIJJJJ@FHIIIJJJJJGGIJJHHHDEDFFFFEE
@2HP
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJCFHHIJIJJIJJJJJJJJJJJJJJJJJHHHFFFDEEEEDDDDDDDDDDDDDDEEEEDDDDDDDDDDDDDDDD
@2HQ
GCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAGCACAGGTGTC
+
CCCFFFFDHHHHHJJJIJJJJJJGJJJJJJJJIJJIJJJJIJIJIJJJJIJJJIHHHFHHFFFFFFCDEEDEDDDDDDDDDDDDDCBBDDDDDDDDCCDD
@2HR
AGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGG
+
@CBDFFFFHHHGGGIIJIJIIJIFBBGHHJCGHICEAG?DHHIJJIJIEHGGH@HIFIGACHEFHHFFFFFFDDDCCEDDCCBDDBDDBDDCDDEDCDDDD
@2HS
CCTGCGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGGGCTGTGCGGGG
+
@@@DBDD@DABFHGB@GED6@@@AFAFHGBGHHHHD?<'099BB)5?39A93933>9-0&02>>?98<8<@@CCCCC>?&+588<AA(4?8<9<2>A9<>&
@2HT
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@@@FFDFFDDHHFHGGIIJIIGIFB@CDGEEHJJJIDHIIEGIGIGGGIIIIFCEFHHEEEEFCEEECCCDCCCCCCCDCCCCDCCCDCDDCDDCCCDBDB
@2HU
ATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATT
+
<@@D?D3BFHFFBGBDFHGBBBCFCHIGGDFFHIEGIB?DFHIFHGI>BHGIIBCEECDGGGIIIECHIG@EHGEEGGF>EHHHCEDCDD@CCBCBBBABC
@2HV
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
C@CFFFFFHHHHHJJJJJJJJJHIJJJJJIJJJJGIJJJJJJJJJJHIIIIJHHJHHHHFHHFFFFD>ACEDDDDDDDDDDD>CDDDDDDDDCEDDD@CDD
@2HW
ATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIIJIIJIJJJJJJIJJJJJJJJJJJJJIIJJJJJJJJJIGGIIIJHHHHHHHFFFFEECECDDDBDCDDDDDCE
@2HX
CTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATAC
+
@CCFDFFFFHHFHJJBHGCFHGIIJJIIJIJJJJJJJJJIJIJIIJJIJIEIGHBBHHGHAAEHHFHFFFFF?BC>AD?A>CDEDDDDDDDDDCCCCDDCC
@2HY
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCT
+
B@CBFDDFHHGHFGFFHEIGHIIIJIIEEIDHHGGGGHIIGIIHGIJJGGIGFIIGGCHIIEGHIIJHGDDD@BA@CCCCCCCCDDCDACDDACDD?BD<?
@2HZ
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
CCCFFFFFHHHHHIJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJHIJJHIJJJIJIIHHHHFFFFCDDEEDDCDDDDDDDDDDEDDDDDDDD
@2I0
CCCTACTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
CCCFFFFFHHHHHJIJJIJIJIGJJJJJJJJJJJJIJJJHIIIIHGGIGFDFEGGHDDDDDDDDDDDDDDDDDDDBDDDDDEEDDDDDCDDDDDDEDDD
@2I1
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFFFFFHHGHHJIJJJJIIHIJHIJGIJJJJJIJIIJJIJJJIJJGHIJIIJJGGGGHGGHIIJHHHFFFFFFFEEDCCBB;BBCDCDDDACCCCCCDB
@2I2
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
CCCFFFFFHHHHHGHIJJJJJJJJJIJJJJJJJJJIJJJJJJIIHIIIJJJJJJJIIJJCGHIGHJH;CHFEFFFEED=ACDDCDDDDDDDDDDDDDDDD9
@2I3
ATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCC
+
?@@DADDEHFFCCFB=AEFHDGIBHHDFB?BFCHFDFHGIECGCG@G:=D<CDCCCECAAC@>>C:C:5@>BDC@@@+25?49@@
@2I4
CCCCAGAGTAACTTTCAAAACTGAGTTCTCAGCTTTGCTAGGATGGGATGATGGGGTTAAGATACACATCGTTATACCCCCTCCTTTGCTAACCATGATG
+
CCCFFFFFDHHHHJJIJJJJJJJJJGIIJIJIIIJIJJIIIJHIJJJGHEGIJIJIHHIJIJJJJAEHIGGEEFHFFFFFD>?BDDDCDDDDDDDDACCC
@2I5
GGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCT
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJJIJJJJJHIJJJJIJJJJJJJIJJJJJJJJIJJHADDDBDDDEDDCDDDDDDDDDDDDDDDDDDDDDDDD
@2I6
GGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATC
+
?<??DBDDHDAF>CGHI@?H>@FFEHIIGCE?@GFDFHIHG@DGGGBHFG@BBB3?F@@=;@5;AHH=C3=77);;=>C>:@>;2@>->@:A>ACCA@>>A
@2I7
AAGGCCAAGGGATCTCTCTGTTTTTCTGGGGACAGCAGATCTGCCAGAAATTGAGGGTGAATGACAGCCTCCACCTTGGAGACAAAGACCTTCTGAGAAC
+
@@CDADDDDDBBCFGEEBHDEFEEGIIGIGGIBFHGGIFDDHH@FBDDHFHCD>BGCCCDEAEGHHHCHEDBBCBBEEC>?A==AC?CCCCC?C@ACDDC
@2I8
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
?BBFFFFFHHFHHJIJJJJIHIIIJIIIEHJHIIHIGIGIHHIFEHIIBGGGFHHGGII;?EHGHFFFFFFDDDDDDDDDD@@BDDDDDDCDACDDDDDDD
@2I9
TGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTG
+
;@@DBDDDFBCFBDFHB<HGHGEG?FEFHHFHGHGEIHCBHIICAFBHIIBFEHAECEAEAEEDECACB@BBCCCACBB@@AA4>@B@CBCCC@>@:>CAC
@2IA
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFGHHHHJJJIJJJJJJJJJJJJJJJHIIIIIJJJJJJHIGGIJJJIIIJJIJJJJJJIJJJJJHHHFFACACDCCDADDDDDDDDACCDCDDD+
@2IB
GGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCT
+
BC@FFFDDHHHHHJJJJJJJJJCGHJJJJJJJJJJJJJJJJJJJIHHHFFFFFEEEEEEDDDDD@DDDDDDDDDDDDDDCD:@B>@ACDDDEDDDEDDDDD
@2IC
CTGCCACTCTGTTTTCTAAACATTTCACATATTCTTTCTTCTTTCTACGACACTCTCGAGCTGCTTCCCTGTTCTTCATTAGACGGACCTCTCTCTTTCGT
+
=@<BDDDDFDFHHGI@FGBBA?CAHE@DHGHCH?FGCEHAHIGGDGHGIEHHEEBBFHC:F@;FDGDC7@>EFHHCECDC;;)>A<9>>AC>:@CC@@;?2
@2ID
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
@?@DFFDFHGHHHIIGIGIGAHHIIIIGHJHIJJHIIJFEGIJJGGI=BCAEHDGHGIDCCEHIGIEHAEEFFEFBCBCDC@@B(8?8<B@BDD@CDDDD
@2IE
ATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGAT
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHHHHFFFFFEEEEEDDDDDEDDDCDCDDDD
@2IF
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGAGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGAC
+
@@@D=B?>+AAFF2AA@BAEF<AEGEEF@E@CGFIFBFFIICBAFD>>F=AFBDF)..@C@DCAE=C;AE3@:;3;ACA@BC;AB@BB<<?(895<<0<>A
@2IG
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACTTGGGGATAACTGTAGTTACTCT
+
CCCFFFFFFFHHHJJJJJJJJJJFHIJIJJJCFHJIIIJJJJDHGJJFHJJJJJJJJIJJJHHHDFFFEEEDDEDCCDDFDDDDDDDDDDDCDDEEEDDDD
@2IH
GTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTC
+
@C@DDFFAHDDBBFGHGHGGIIIGGECHIIEHG:CFHIEDH<?D9DDDFEBFCCFHHICFHEC@DHECE>?>???@CC>AD@BB:@BCCB<ABADDDD?3:
@2II
GTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTT
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJJJIJJJJJIJJIJJJJJJJJJJJJIJJJIIJHHHHHHFFFFFFEE
@2IJ
ATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGCTGAAATTGAATCTGTAATTT
+
CCCFFFFFHHHHHJJJJHIJHIJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJIJJJGHJIJGJIJJJJIJJJIJJJJIHHHHHHFFFDFFEEEEEEFEE
@2IK
GTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHGHHFFFFFFFEEEEEDDDDDDDDDDDDD
@2IL
AGCAGAACAAACCAAAGAAAAAGGAGAAAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCC
+
@@BFFFFFHHHHHJJJJJJJIGIJEHIGIIJGIJJJJJGHIJIJJJIJIJJJIJIHGHCHFFFFDCEEDDDDDDD>ACACDDDDDDDDDCDDDDDDDDCDB
@2IM
TAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGC
+
BBCFFFFFHHHHHJJJJJJJJIJJJIJJJJJJJJJJIJIIJJJJJJJIJJIJJJJIIIIJGHHHHHHHFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDED
@2IN
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@B@FFFFFFFHHHJJJIJJJIJJJJJJJJJIJJJIIIJJJJFIIHIIIIIHHJIJBGGGGIJIIGIIIIAEHHHHHCDFFCEEDCECCEDDDCDDDDD?CC
@2IO
ATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATC
+
@@@DDDDDGHHHHGJGIJJJJIIJIIFCFHJIHHGGEHGHIJGCFIIJJJJJIJFGGFGHGEFFFCDECECEDEEDDDCDDCCCDACDBBBB@CDDD?ACD
@2IP
CATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGT
+
BB7DDFFFHHHHHJJIJJJJJJJJJJJIJJJJJJJJJIJJJIJJJJJJJJJJJIIJIJJJIJJJJIJIJJHHHHHFFFFEEEEEEDDDEEDDDDDDDEDD>
@2IQ
TGGGAACTATGAAAATACTATAGTTGAGACCTTCAATGACTTTCTAGTAACTCAGCAGCATCTCAGGGCCAAAAATTTAATCAGTGGAAAAATAGCCTCA
+
@CCFFFFFDHDFHIGGIIGIJIGFHGHEHIJIGIJJJJJJGJJGIHGHHIIJIIIGIIDIJHIGGIJIJIIJJJJHHHHHHFFDCDCFEEEECDDDDDDD
@2IR
GTCCCACTTTGCGGCTCTCGCGGAGGAAGCCCCGCAGGGAGCCGTATTTGGCGTACTCCACGATGAGGAGGAGCGGGCCATCCTGGCTGCAGGCCCCATAC
+
@CBFFFDFHHHGHJJHHHJIIIGIJIIGGIJIJJHHFFDCCBDDDDBCFDDCDB@BDDDCDDDDDCCC@BDBDDDBDBD?CDDCDCDCBDDCBBBDDBDCC
@2IS
GTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGTAATGCACTCAATGACCTCCGTGTTTGAGAGTTGGAACCATGGCTGCTTTC
+
B@BFFFFFGHHGHGGGIIJIJJJJJJJJIIIIJJJJJJFIJGHFFDECED?CCEDCCDDDDDDDCDDDDDD?@DDDDDBDDDEDDDDDDDDCDDDDDDDDC
@2IT
CCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCAGGTCTCGGTGCACAAAGTGCTGGGAGGCCAGGTACACCATACCCGAGGCG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIIIJJIJJJJJJHIIHIJIIHIJJJJHIHHHHHFF@DFFEEDED@BBDDD>ACCDDDDDDDDDDDDDD
@2IU
GGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGC
+
?<@FFFFDFF?FDHGHIGDFHI?CEF@DAFFFGDGGIGHIGGIIIIIIIIGGGIC@CAEEEEFFFEEEDEDCCC>=AC@@@@ACC=?@<>CCCC@BCCCCC
@2IV
AATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTG
+
CCCFFFFFHHHHGIJJJJHHGIJHIIIJGIJIIFGIIIIJIJJJGIIIIHHIJJJGJIJJGGIGJIJJEHHFHHHFF>@BD?CCCDDDCDDDDDDDDDDDD
@2IW
CCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTC
+
@@@?;BD?D?:BDA@FEGIGD;FHGHE@EFHCAECEEEGBDDGDHBB@?)9BDHH>GD<FD@H@BBHEFGHGC;==8CG)>C==?:A;;?<;5;9ACC>>
@2IX
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGG
+
CCCFFFFFHHHFHHHIGHIJJJIIIGGIIJJJIJIJJHIJJJJJJIIJJDDDDDDDDDDDCDEEEEEDDDDCCDD?DDDDB?CDDEDDDDCCACDDDEDDD
@2IY
GATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTC
+
?<:DDDADD?CBDEED1:CDD00:BDB009?@DDD89998=BEBECC>===@=C=C=CAD==??AD@;AA@ADAB;3;;:259,55;;5>AAA<44<?9;?
@2IZ
CAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGAC
+
@@@FDBDDHDBHAGIGFDHBGH;EFFFHIIGIII<DFHFG@FIHGIFBFAAEEGEE7AEDCCFDDCEACDDDC?BCC;>CCCCC@@8?CCDCCDDDDDC>C
@2J0
CGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGC
+
@@@FFFDDDHDHHGGIJIGHHIIIIJFGIIIDGHJFGIJIJGIHIJJGIJIJHCHEHGHGIGJFIJH7AD?BBA@ACCCCDDDDDCCCCDD;:CCDDDDDA
@2J1
CCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTG
+
@?<ADDDABFFHDIGIIGGH>AEGFHGBFHBGCGEH:CGIDDHGDHIEFEEGGBBDHGHIIIIIIGIICHCGEIHH)@=>CHHEFDFFFFFDCEDCDCCC
@2J2
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHGFHHJJJIJJIJJIJJJJIIGGHIIJJJJJJIJJJDFGIJIIIHIIJIJJJIJJJJIIGIHGHFDD;BCDEDDDDDDDDDD?CCDDDDD<
@2J3
GTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTT
+
CCCFFFFFHHHHHJHIJIJJIJJJJJJJJJJJJJJJJJJJHJJHIJJIJJJJJHIIHHHHHFFFFFCEEEEEDDDDDDDD<CDDEEDDDDDDDDDDDDDDD
@2J4
GCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTT
+
<@@?DBDD<CFDDHIIII@FEEEFHCGE@<BFGEHIIIFFH<BGDEHHEFFGICH@FHGGBDAD@FGEHEEE;6?=AEE>@CE9>?>?<A8<:9<@CCCCC
@2J5
CTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGC
+
CCCFFFFFHGHHHIJHGIJJIJJJJJJJIJJIIGHHHJIIIJIIIIIGHIIJJJGIJJJJJHIJGCHJJJJJIIIIFGGDFHHHFFFFFDDDEEEEDDDDD
@2J6
GCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATG
+
:;??A=AA=DFF8AFGID?F;AAF<A2A?AFHIBB?:??9DB0??88990B?8/BFG48=B@84=F@==CE7=)=AED?DD6>B3(;(5;@>;:ABA;@55
@2J7
GTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGAC
+
???DBDDDDDDDDEEDEI3A<F:<AAAFE@EAEC<D;C=@0:?D<?D<D9D8?BBBBBCADCADCDCEC@CD>CC;?9=D@@A@;>A??;?A>>???A>
@2J8
GGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCG
+
=?@D?DBAFH:DBHCGFGHCIGHHGCHBBFEHEEFGE@DGHGII3?GFHFFGGEGHGCHGDGIFDCGGEGHHGFDEB=@=ACCCCCCA>CCCCC<B?@CCB
@2J9
CTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGG
+
CC@FFFFFHHGHHIIJIJJJGIIIIJJJJJJJJIJJIIJJIJJIIJIJJJJJJ;BHBEFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDCD
@2JA
GCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGAATAGGAGGCCTGGGTGGTG
+
CCCFFFFFHHHHHIIIJJHIJJJJJJJJJJJIJJJJJJJJJJJJJIJIJJJJJJJJJJJJEHIHHHHHGFFFFFFEEEEDD;ACDDD;CDBDCDDD<BD<B
@2JB
ACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAAT
+
CCCFFFFFGHHHCFHJJJJIJCHIIJJJIJJIJIIIIIJJJJIIIJJGGJJ8BFHIJHHIIIIIIJJHFFFDD?@DDBBDACDDDDDDDDDDDCDDDDDDD
@2JC
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
@CCFFDEFHHHHHGCEEHII@DGDHGEGIJIJIIJEHCHFFDDCCDDCDCBD>CCCACCCCDD>C:>C@@CDCAA?B@BCCC>:@CCCDCCBABCDCC>@
@2JD
CTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAA
+
@?8?BDA::CFBFFGABFHEE9FHCG<<CHGB?@CE99CD=??BD?FFGG@C4*9DFBFBCFGDFF@@C;@;;)=7)7=A>E>ECD;;@6>:66@;5@@A
@2JE
TGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGT
+
@@@FFFDFHHHGHIJDHIJJEHHJGHJEGIIJIIJJDHGGGGBBFGIJGGFHIGIIJGIGEIIEEHHHEF=DDFFECEDEEED@B?;:?CCCCCC4>C@C4
@2JF
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
BBCFBDFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFFFEEEEEDDDDDDDCDDDDDDDCDDDDEDDDD
@2JG
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
CCCFFFDFHGGHHJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJJJIJIJIJHIJJJJHHHHFFFFFFEEEEEEEDDDD;?DDBCDDEDD@CB
@2JH
GCCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGC
+
CCCFFFFFHHHHFIJJIJIJJJJIJGJJHGGIIGIIJIJJJJJIGGIIJJIGHGCHGIHHIGHGIIIIIJIFHEHHEDDFFFDDDBDBCCFDEDD@BDDDC
@2JI
CCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTG
+
@@@BDDEBDFBFHBFGIIIIGIEDFHIGHGEGGE9?DDGHBFHBGGI>GEGFDEH=@EECEEHAHFEFDB.;AC=C>?@CDDDCC@C@CCFCCCDCCDCC@
@2JJ
CTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGG
+
BBBFDFFFHHHHHIIIFHIJIGIFGIIJJIJJJJJJJGHIJJJJJFHIIIJJJJJJ@GHHGEHHFEDEEEDDDFDEEEDCCDDDDDDFDDDEEDDDDDDDD
@2JK
CTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGC
+
CCCFFFFFHHGHHIHIJIJJJJJJJIIHIJJIGIGIJJJJFHIJJJJIHHIJJJEHJJIJJJHHHHHHHFFFFFDDDDDDDDDDD@CDDDDDDDDDDDDDB
@2JL
CTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
==@ABDDADDF?DG@FGHIGDGGBF9?FAEEF@DHDGIA2=C@7=CGAEEHGIFEFFEEEEEEECC@CC>CC>C;A@@AA>C@ACC@CCCCCCBBBBB8@@
@2JM
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
CCCFFFDDFHFDBGD@@GFHIIIIIC9FB?EEFGEBDHGIGG6?DE;FDAFEAHGGG@;<?DDDEAEBDCCDDCCDC@CACCCB>@ACCCAA@DC>>CCCD
@2JN
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGT
+
??;;::=DFCAD:EA:CGE:<3<CC8?@FE;DBB?8B??88(8B9CF387=E;@@=C77=7=C7.5?/,3,---55((9<ABBB5;:(4@B>::3:>>>3?
@2JO
GCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATC
+
@CCFFFDBFDHFFBGGGIIFHIEGHIIGIIAGGCGGHGIGHII<GB:?GIIHGHGGIEHGH<DDFGHEGHII>;@GE2=EEHEGHFD7?BAC>C@@CC>A>
@2JP
CTGTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTACACACAGGTCTACAAGGTCAACCAAGGTGAGTAAAGGACCATAAAA
+
CCCFFFFFGHHHHJJGIIJJHJJIJIJHGGIJJJIJJJJJJJIGJJIIIJIJFHIJJJJICFGIIJJIIGIGIHHHHFF?DFEEEEECEDDDDDDDDD
@2JQ
GAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTT
+
CCCFFFDFHHHHHJJJJJJJJJJJHHHIJJJJJJJJHIJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJJHEHHFFFDFFEEEEEEDDDDEEDDDDE
@2JR
CTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTT
+
@@@DDD?DFHDDAFFEFEAF?CC?):CGGGD??FHG?FC*?F6??DHIHGEGGIIIG=>DECA=EHHE?BDB@CCB?@=;?<?5:@CCCCCBBBBBBB@CC
@2JS
CTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCG
+
8=@DDDDD?BD?FDD?E@@1:?FFIF3?FFDDBFEEC7=F;;;A=C7;BB@BCACAA53=;5:A>A?@B59>AB:48+28299@BB?BB>:B>23<>>AA5
@2JT
CTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATT
+
1=?=:B::?C,2A@??BE@<EFAC@BAEE@A9CAFE9BCCE)??9:::?9?DCEEC4DB49B(8=CE@)8@ACECE=).7()?C(;?DA6>AAA>=/;<3:
@2JU
GTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCTT
+
@@@FFFFFHHHHGIJIJGGHIJIGIJJIJIIIGGHIIIJJJIJGHHCHIGIHHHHGH?CFFFFEDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDCDDDD
@2JV
GGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGC
+
?<?7D>D:1A:2<4<?22<CF@<EBAF9AFEBEE3E9DDCDED9*:B3))(/?*=B<BC4B=AC9@D7AC7=CA?)6?@37.6>AA>A@A5/,,<;;;,3<
@2JW
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJIJJHHIIJJJJJJJJIJIIJJJIJJJJJJJJJJIIJJJJFIJJJIJHJGIGHHHHFFFFFFEE;@CBACDD5>BDCDDDDDD<AC
@2JX
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
CCCFFFEFHHHHHJIJJJJJJJJGHIJIIJJ?GHIHGJJIJJBFGIJHHIJJIJJJJJJJJHHHBDDFDEEDEED@CDDDDDDDBDDDDDDDEDEEEDDDD
@2JY
GCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGG
+
CCCFFFFFHHGHHIHGJJJIJGIJJJJJIJIJJJJJJJJIJJJJIIJJJIHHHFFFFFEDCAEDDDDDBBDDDDDDDDDCD>CADDBDDDDDDDDDDDDDB
@2JZ
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
CCCFFFFFFHHFGJHGIIIJGHJIJIIJIJJIJJJHHHHFFDDEDEEDDDDDDDDDDDDDDDDDDACCCDDDCDDDDDDDDCCDDDDDDDDDADDBDDDC
@2K0
ATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTT
+
+=@DB;DDDFDA8BF>FGBAC:E@H?BHCC4+29?FF9?FD??@DBFD?FG>FFFFGGDFGDDF@FCFAFGICFFG:=FGCEICF>:76=;C);7@BB7@@
@2K1
CGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGG
+
CCCFFFFDHHHHHJIJGGIEIGHIGIHIIGIJGGGIEHHGGIFDIIEGGHDFECHGGGGIGGGHDDBD;@C<ACCCDCDDDDD:>C<@CCDDEDDCCCCAB
@2K2
AGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTC
+
@CCFDFADDHFHAHGGIIBHIIGGEHIIGGIIIIIIIGIIIIIIII@FBGHHBHIIGHDBAAHIIIIIIGIBGCHFEEGEHHGGGGEHHEEHEHDFFFDF>
@2K3
GCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATC
+
88:DDDDDD?AF?FAB@BIEHII@3AF>E@A;?EHA>99*?FD<<:?4DGCHB?90?<8???DFG==C@@=@FF;D7CC;;;??B7;;CCECC>;>@A?B;
@2K4
ACTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
CCCFFFFFFHHHHIJJJJFHHJJJIIIIIGIIJJGIIIJJIJJFHHIJJGHJJJJIJIIGJHHHHHHHFFFFEDEECCCBBCBBACDDCCDDDDCDDD?C@
@2K5
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CCCFFFFFHHHHHJJFGIJJHHIJJJIJJJJJJJIJJJJJJJJIIJJJJJJIJJJJJJIJGHAEEFFFFFFFEEDEEDCDDCDDDCDDDCDDDDDDDD3<B
@2K6
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGT
+
C@CFFFFFGHHHHJJJJIJJJGIJJIIHHJIIIIJJGHHEFGHHIJJIIJJJIHIIBHGHHFFFDDDDBDDDDDDDDDDD:ABDDDBCCDEEEDCACABDC
@2K7
CTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGT
+
CCCFFFFFHHHGFIJJIIJIIIJICHHJIIJIIJJGIIIJGEIJIDGEGFHIHIJJDEB@D@9<?BFC<CEGDHHCGHGCH@EGCE>EE;??;@>@CCE@
@2K8
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGGGTAGAGGAATAGCTGGTAGGAGGGG
+
@;??=ABDABHHFB@:<C@EAFCGICE?FB9C?:9BFCBFEHDH?DBDDFDG>=B>FC@;@>G@C@=);BEHE'5>(;6;@B5A(:(>CCC<@?@A><&
@2K9
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGG
+
@@@FFFFFGGBHHIGHIJJEHHGHCFHIJGHGGIIJJIJJIJIIJJJJIJIIDGIIJIDHIHGEFEFFEF@CCCECCCCCDDDDDDDDCCDDDDDCCCDCD
@2KA
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
@C@DDFFFDHHDAGGCEGGHJHIJJJJJJGHFFGIJIIFIIIIJIJJIIFDIGIGIEIGIJJJICGEAHHHHHFFDDEEDDDCCCDD@CC?BCDDCDDDCD
@2KB
CCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCC
+
??@FFDF?HHAFDG?CEDHAHADDHBHICCFF@GGIGIII<AF@FGI9?DDBBDFBAGIE=CEC;AAACH;BB;@>ACEC@@>C>@C;5;589<?<CC@C
@2KC
CTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJHHIJJJJJJJJJJJGHJJJJJJJJJJJJJJJJJJJJHIJJHHFDEDEEEEEEDDDDDDDDACCDDDDD8ABD
@2KD
TTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTG
+
CCCFFFFFHHHHHJJIJJJJJJJJJJIJJJJJJHHIIJJJJJJJJIJJJJJJJIJIJJJJJJIHHHFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBD
@2KE
TCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGG
+
@@@FFFFFHHGDCGEHIGHIIIIGIIJIJIIEFEHGII?GGGJ:??FBEHHHJJIIHGGGEIIJJJIJHGECDDFDDECCACECDDCCDCCDDDDCCDCD?
@2KF
CTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGT
+
@BBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJIJJJJIJJIIHIJJJJIJJJJIJJJJJJJJJJHHHHHFFFFEEEEEEEDEECD
@2KG
CTCCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCT
+
CCCFFFDFFHHHHGHJJEHIJIIJHHJJGIJJJIJJJJIIIIJIJJJJJJJJJJGIIJIGIIFHHFHHFFFFFFCEEEEEEDDDDDEEEECDADDEFEECC
@2KH
CTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGA
+
@@@FDDDDBFHHDHGGH>AAECGEGHHIFGADDGHGD@@?BF8?BFGGHEC=@A@EEE;ABDECDE@AA;?B@CCACCCCACCCC@BBBBBBBCCC<?@B
@2KI
GCTGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCG
+
@CCFFFFFDFHGDIIIJJJIGIJFHIJIIIIIJIJJJIJJJJIJJJIJIGEFGEFFFDDDDDDCDCCDDCDDBDDDDDDDDDDDDDDBDDDD?BBDBDDDD
@2KJ
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGAGGTCCTGTCGGAATGAACTCTGC
+
<<?DDDDD;CBD4+2<:EFF99+CEEB?<C<D0DDDD<D*/?DDC9;=B7=@C@D3=AD@C>C>D;>3;;A;@;;;'(''(9AA:>4<;9<8:+:3(44:(
@2KK
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTC
+
@@@FFEFFFHHHH@FIIJIIJJJIGJGJFBFHFIJIJHIIHIJJJI?DGIAHIIIIJ@EFHHHFFDEDEEDDDDDDDDDCCDDCDCCDDCDDDDCCCEDDD
@2KL
CCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGA
+
@@<DDDAD2ADDFFE@CEFEE>:AFGD9C;GDFEFEB1?FF?B>FB<BBFFFFF>?FEF<BF<FC28=@)==DE)7?CCCBDBD3;A;;@>B:5@B=;<@
@2KM
TAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGT
+
@@CFFFFFHGHGHIIJHGIIJIJJHGHIJIIJJJJJJIJJIJJHIIJIJIJJJJJJIJEHIFFCHHHGIGIIGCHHHGDCDEFEEDEFFEEDDDDDBDDDD
@2KN
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTC
+
CCCFFFFFHHHGHJJJFHIJJIJJJJJJJJJJDHIJJJJJJJIIJJJJIJJJIHFDDDDDDDDDDDDEDDDDDDBBBBCDDDDDDDDDDCD>CBACDDDD
@2KO
GTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTC
+
BBCFFFFFHHHHGIJIJIJJJJJIJJJJJIIJJHHJJJHIJJJJJIIIIJIJJJJJIJJIHHHHHFFFDDDECDDDDCDCDDDDDDDDDDDDDDDEEDD?C
@2KP
CTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTT
+
@CCFFFFFGHHHHJIIJIJJJJJJJJJJJJJFHIJJJJJJJJJJJJJ?EGGGFHJJJJJJJJJJJJGHIJJJJJJHHHHHHFFFFFFFFFEEEEEDDDEDD
@2KQ
CTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTC
+
@@@==DDDFFHHDGIIGABGGCDFEGGIG@F.BFGCHCGGGIIIIIGGIIEFEEDBBC6>CACBCCCC@A>5>>@CC@C@DC9<<<8@09@>BCDED::CC
@2KR
CTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGT
+
1?:DDBDDDCAF<AFB:23AIHEEDCEBACDFIIF;:E9?9:9CFC9D?:F??9D9**/?F<88=C>8.)/8=CG@FI==7@7?EA>E3C7).;?BACCCB
@2KS
GCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTG
+
C@CFFFFFGGFHHJJFHGIIHHJJGGDHIIJJJJJJGJGIJEIGEIIJGGGGJIIJJGGFGHHEFFFFEEEEDDD9=B?CCDDDAD@BDDDDDDDDDDDDD
@2KT
CCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGT
+
CC<DFFFFHHHHHJJJJJJJJIJJIJJJJJJFDDDDDDDEEDDDDDDDDDDDBDDDD@DDDDDDDDDDDCDDDDD<BDDDCDDDDDDDDD5<?CDEDDDD<
@2KU
CACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ(;@DHIHIIHHHHHHHFFFFFFEEEEEED?BDD
@2KV
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
CCCFFFFFHHHHHJJJJJJJJJJHIJJHIIIIJJJJJIIIJFGIGIJGIIIJHIJJJJJJGHIIJJIHHHEDFFFCCEECCDD@CDDCDCDCDDD8?BB@@
@2KW
CTCTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCTTTATCTTTTTCATTTTCCATATATTCACGAACCTGATCCACATGAGTTGAATAAACC
+
@CCFFFFFDHFDHGGEBHGI@FHHHGGEDHIIIEEEDDG?FBGIGG@DGHHGIIGIGGGHIIGHCGGBB==GI>GAEC3@CFCFDCEACCDCDDCDDACC
@2KX
CATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATG
+
CCCFFFFFHGHHHJJJJJJJIIJJJJJJHHIJJJJJJJJJJHIJJIIJIIJJJJGIIJJIHIIJJJIIJIIHHHHHHHFFFFFFEEDEDDDDDDDDDCDD
@2KY
CTGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTG
+
@@@DDDDDA?FHHI>ECFG<;CCF93AADGGDHG<DFBDE9DFEGF<8?F@@48/B=@:=C@=E=CCHEECBBBE?BA;=@'8?88(>AC:>CACCCCC+2
@2KZ
GTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGC
+
?@@D;DDDH0<CFABHGHDG?CBHGGHG@<?FGGGCCGHB?BHGAEBBFCCCCF@BGGC:6=A?CB6?AABBBB059>@?8-9?8?CAACCCCB?CCCCB@
@2L0
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGGGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTT
+
@@@DADB?AAF?2AEGFGE@:C<+ABAFFD:FAGFDEIE@CA9CFEEEEEDB>B>B>@BB?3>A(88;B&8334@@BBB:>AB<(+505-8>A@BABB@B:
@2L1
CAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGT
+
CCCFFFFFHHHHFIJJIJJJJJIIJJICFHIJJIIBEGJJJIJIJJJJJJJJJGIHHFHGFFFFFEEEDECCCDDDDDDDDDDDDDDDDCDDDBDDDDDDA
@2L2
CGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@@7DDFFDABDF?AEGFHEBGHIFGCBGBH9?D<?*:BD)?=@@@=FGDEEHIIDEGIFHBED6)7@DD@;=A?=BACC@C:>:;;>CCCACCCA@3>?C(
@2L3
CCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGG
+
;?@BDADDHFHH?DGIGIIGG>BFHHBFGGBGG;GC:CHF@G<?BFFHIIDHC?B?F=FGBFHEGFHI@EEE<CD89><>@@@ACCCACBCCCCCBBABB
@2L4
CCGTCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTG
+
CCCFFFFFHHGHHJJJIJJJHHIJIIJJJIIJJJIJJJIJJIJJJJIJJJIJJJJJJJJHHHHFFEFCECEECCDEDEDDDDCCDDDDDCDDDDDDDDDDD
@2L5
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTC
+
?;8BBDFDFFABHGHI:CHHGIC@HCGIC@FBEGEIIIHIIGDGB<8BFHBHGFDBC??CBB>:AC:>:@>?8;5<5-:>CCCDDBBA?93+:2++:AC>
@2L6
ATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGG
+
@@@DDDDDFHDC?AEGGGEBB:?EFBG<F<DGDGIGGIEGBEGGE=FFFGDDHGGGGIEEE;CEE@;A?CBDDECCAAC@???@C?<@CCCCAC>CC@CCC
@2L7
CACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCAC
+
CCCFFFFFHHHHHJJJJJJJJHHJJJJJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJFHIJJJCGIIIHHGFFHFFFFFFFEFEEEEEDDDDDDDDDD
@2L8
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CCCFFFFFHHHGHIJJJJCGHJHIJJJIJHHIJIJIJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDCDDDDEDDDDDDDDDDDDDDDDDD
@2L9
CTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGT
+
?7=D=BDDDA:,A<<B<D?3C<CE::CB>ADB?<C+:???DDDDEIA9B4888=B7787=AE:;3A7=AAD).;7@DA@A>93;5>>>;>(55<??>;>5+
@2LA
CTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGG
+
@@@DDBDDHBHH;AFHAGGIA<AHEFHGDFEHAEBGBEHGG@CGDBD>BFBDDGCB?F@F=FCBC=;=>=D@HA3;)=C4499?(;>>>@CCBAAC;B?BB
@2LB
CCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATT
+
CCCFFFDDHHHHGIJJJJIJJJJJIJJJJIJJJJJJJJJIIJJJJJJJJJIJJJJJIIJJJIJIIJJJJGGGIJJHHHHHHHFFFFFFEEEECDCDEEEEE
@2LC
CCCACGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATT
+
=@@DBDDDBF<DFFD;FFAHHCE>9E:11CB1?DG8??D989DFF>=<BD@=FFD>;@EFFB.7?;7;@=;->;?B,91?BB?BABA>>@44(::4444:
@2LD
TAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAGATCGGAAGAGCACCACGTCTGAACTCCAGTCACGTGAAACGATCTCGTATGC
+
@@@FFFFDHFHGHIGIIIGHIGJIHHGIIIIGGIIJJJGGH>HHGIJHIIIJHJIFEHGGIIJJJHHGFFFFDFEDCEEEACD=ABDDCB?A22@A@BCDD
@2LE
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
@@@FFFDFHHHHHIJIIJJIFIJJFIJJIJIHIIJJJIJIGIFBFHGGIFHIHGIIJJEFHHHF;@CCECEDCCEDDDD;CDDDA@9@CDFDDD>@ACDD
@2LF
GGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGG
+
@?@BFDDDHA:??GIGFDFEGGGHGCHHEBGBF<BEEGIIII=@FH>=C@GCE;@7?C;E;CCEF@??AC>>>6@C@=;(:>(;@@CC=(::>CBACC>A@
@2LG
GAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGCCTTC
+
B@@FFFFDHHHGHJJJJJJIHJJJJJJIIJIIIIJJJJJJJJJIIIGJJJIJJIIIJIJJJJJJJJJJEIGEHHHFFFFDEEEEEDDDDDDDDDDDDDDDD
@2LH
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJHHHHHFFFABDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@2LI
CGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGCGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTC
+
:??BD:D::)C?0))8888>D338B>>A><???7&&)67783+(3333+(9AA2(+0707<<=<>A>A(:AA82;23>:A:AA>>+824>)&009595>++
@2LJ
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATC
+
CCCFFFFFHHHHHJEGHIFHIJCGHIHIIJIJJFHIJJJJJJJJJJIJJJJJJJJGIJJHHHHHFFCDFEEEEDDDDDDDDDDEDEEEDDDDDDDDDEDDD
@2LK
CCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTG
+
CC@DFFFFHHHHHJJBGHIIIJJIJJJJIJJJIIGHIJJIIHIGGIIJGGGGHGGGHJGGBCDGAFHEGIHEHHGGHHHFFFBDEEE?CCDDDEDEDDDD
@2LL
CTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
@@@BDDDAAAFFFEIGHG@FGHAHGHGIGHGDHAGHGI@CG@DHGIIIDCHGGIECFEADHHB,9;AA;>;(6;>;@C@A@C>C>:><,(:AC:>C>>:@<
@2LM
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJIGHIJJJJJIJIIJJJJJFHIJHIHHHHHEDFFFDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDD
@2LN
ATGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAAAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTT
+
??=B?;;2A4+<BFE:CF><@:AD@D>CHFDF3<BFBEEGFFFIIEIIIICFFEFFC;BD<F:DEFF>:====C@CDCCEAE@=(;BDDDCC;>A665AA
@2LO
CAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTC
+
CC@FFFFFHFGFHJJJGGGGIIHIJIIHGIJEHIJJJJJIJIGGJJJGHIJIHIIIHIJGGHJIIGHGHHHEEEFFFFEEEECDCDDDCDD@CCDDDDDDD
@2LP
CTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCG
+
CC@FFFFFHHHHHJJJJJJJIIJJJJJJJJJJJJJIJIJJIJJJJIGJJEIIJGHIIJIJJJJJJJJIEGGEFHGHFFEFFFDEEEDCDBCDD;@ACDDCB
@2LQ
CCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGA
+
BCBFFFFFHHHHHJJIJJJJJJJJJJJJJJIJJJJJJJJJJJHHHDDDDDBDDDDDEE@ACDCDDDDDD@DBDD3>BDDB@<9<BB@><BDD5<ADD>?B
@2LR
GTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTG
+
CCCFFFFFHHHHHJIJJIGJIJJJJJIJJJJJIJJJIIGIJIIJJCHIJJJJJJJHHHHHHFFFFDDDCDDDDDDDDEDDDDDDDDDDDDDD@BDDDDDD
@2LS
AATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGT
+
?;?B<D>DDD?:21ADAB:<<AEEDEBECEED>@>DFE?DDDBDEBD<DDDDC9@D>ECC=@BCAE<@@C@@CEE=CACCD??@@;>@A>;;?AA>AA;>(
@2LT
CTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGC
+
@@@FFFFFHHHGHGHIJJIIJGIJIGGGIGIJGHIGIEIJIJGEHEFHIGEFBFGEIIJJJJIIGIJIE5=A>BCCADDDCDDB9@BBBDDCACBDDCCAC
@2LU
CTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGG
+
@@@DBBDDFBH?HGDBDHGEGGGHGHIGCHCHGGEHGCHIII?DBFDBBDGIIECHBF>BGCGEAEEEHHHEEEDCBA>A>@CABCCCCACCCE@CA>CB
@2LV
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
?@=DDDDDFBFF<FBEB@E@CCCE?B?E*?<FGGD>AGBDG>G=3?=GHIFD>@FHECEA>(7==?E;BB:>626>:5@;AC>@CC3:?>A>@>>3?C@
@2LW
ACTGCCACTCTGTTTTCTAAACATTTCACATATTCTTTCTTCTTTCTACGACACTCTCGAGCTGCTTCCCTGTTCTTCATTAGACGGACCTCTCTCTTTCG
+
?1;A?BD:+2CD<?CD?E<FB>EC@D>A4AB<4CA<E4CED?9C9*?9?1?0)008?BAC<5;AEA)777?=CD=;A;7?D)7;>>9;;'(5>AA:5:33(
@2LX
CGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGC
+
??7DDADDDDC>DD;2A;3A:CFC@CF@93BEEEIIBDFIC>?@DD9?DEI7=CBACCDC)=@DEA=ACD?&0))9>:>A9++++4:BBAA32((3<8<>?
@2LY
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
?@@FDDDFHFHHHIIIIIJIIIGGIIIJICDHHJGGGIBGGIGIIIIJGCHIIGGJIJJJGFCHCHDBDBB@CACEDDDD@D@?ACCCDCCCD@CDCDDDD
@2LZ
CAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
@@1DBDFD?AFFHIIIIGGBBFGHB;CF=?FAHG?D@GEHIIBG@HGCDCC;6@CHHGEDFFBB@@CCE>>C>A:@CCCBCCCCABABBBB9-<AA@CC
@2M0
CGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGT
+
CCCFFFFFHHHFFGGIJIIJJJJIJJJJJJHIJIJJJGIJJJJJJJJJJJJJJJJJJJJJGHJJJIJJIIJJJIGHEHHHFFFFFFFEEDEEDCDDDDDDC
@2M1
GGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTT
+
@CBFDEFFHHGHHIHIJJJJJIJHHIFHIGJJJJIJJIIJJJJJIJIIJJCGIJJJIJJJHHHHHDFFFFEEEEEEDEDEEDDDDDDDDDDDFDDDDDDDD
@2M2
NTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTT
+
#11=::????AACBAAE@4<:A@A3+<??4?49?@F4:?*::3?*?BC?<DBFCB998?@BD:88C338@@7;CCD=;?==<77))9;=;5555>=(5((5
@2M3
TAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCT
+
@@CFFFFFHHHHFHIFGHIIJJJJIJJHHIIJGIHIJJIIIIIJGHIJJIJIJIIGIIJJJHJHFHHHFFFFFFFEEEEDECCDCCDCCDDDDDD@DEEDC
@2M4
GGCAGAACTGGCCCGGGCCAGACCCAACGTCCCACCTAATGAAGGATGCCCCTGAGCCCATGTACCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTT
+
@@7DBDDFGFHDHIJGGGIIJJJIGGGGIJIJIJIJJIGIGIIJJFIEGIFHFHFFDEDDEEEEDDDDDDCCCDCCDDDDDDDDDDD9>@CDDDDDDDDDD
@2M5
TGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJJIJJJJJJJJJJIJJJJJHHHHFFFFFFFECFEEEEDDDDDDDDDDDDDD
@2M6
CTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTT
+
@@@D;DDDFDAFF@GFI@BAECI<,CH?E<AE32+AA9?E<?ECD4:C@<?<<?9BF@FBD;4*9DFGAB8=<C==@@:7;=47@E>7=;;@DC@>;>AAA
@2M7
TTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJIJJJJJJJJIJJJJJIIHIHHGHHHFFFFFFDEEEEDDDDDDD
@2M8
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@??DDD;;FBBD?E3EBF<B<CGFF<?FG@FCAGCF8D=BCFFCF8@FEE>>EEE=BD=;@>3;36>>A;@B9:>:AAADD@A(5@>:9??AB??@@@ABB
@2M9
CATTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTG
+
@@1ADBDDHHHHGJIJJJFHIJJJJJJJJJJJJGGJIJIJIJIJIJIIIIJJIJIIJGIJGJIJJJJJJIJGHGHHHH?BDCEEE>ACDEDDDEEDDCDDD
@2MA
TGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@@FFFDDFBFHDFEBAEDGHHHIIIIGIIIIGGIHGIGIADHGG@DDFFHDIIDHGGGGIIFFEHHFBDB@;@CBB?ACCCCCC9?<AABC@CCCCCAAC
@2MB
GGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTG
+
@CBFFFFFDHHHHIFHGGIIIIIJIGJGGJGI?FHIIJDHIGGIGBFHIIIJGIHGIBEDEFFCBABBDDDDDDCDDBBDDADDDD5>B?CA>CDCCCDDC
@2MC
GCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGT
+
CCCFFFFFGHHHHHIJHIJIJIIJGIJJJJJJJIIJCGHIJJJJJIJJIHIGIIIGHF?EFFFFFFDEEDBBBBDD@BDDD@CDDDD8?0>CDCCACCCC@
@2MD
CCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCCCTGCCTCTTGACTGGCTTCAGG
+
@@@FFFDEBBHHHJHIIGGHGCCBFGGIGGHIHIAC?EFGDFBDHGHIJIJGGIIGGFGHIEG?HIHJJIGIJJJHFHHGDCFF7@CEDEEDDBDDBDACD
@2ME
CATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCC
+
@@?B7AAB:FFHFGIHEGIHIIIHBA9:CHB;?FGHGFDAHGGECHIG<EGE7?;>@DCFCDC@BC?CCCCCCC:>C>@BB<BCCCCCCCC@><CACCCAB
@2MF
TCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCTTAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTGGGTGGTCTGTGCATATCCTTGAGTGGGC
+
8=?D7;?D8ACF:CGB<,<BB3:C<AFAHEF?FG?:**??93??0:?FGDAFFFBB?BFFBDF;77=3@:CECFF)-45;@(;((;5@>>@A:A:@(,8?B
@2MG
CCCCGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTT
+
@C<FFFFFHHHHHJJJJJJJJJJJJCHHIJJIIJJJJJJIJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHHHHFFFEFFEEEEEEDD
@2MH
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTT
+
BB=DDFFFHHHHHJJJJJJJJJJJJJJJJJJJIHIJJJIIJJJJJJJJHIJJJJJJJJJIJJJJJJIJCHHIJJJJJJJIJJJJJHHHHHFFFFEECEEED
@2MI
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGGAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
?=?B=BDDBFAFAABB>:?F@:C?9AB<CD=FFFFFE<D9?BFCAEBEFFBFF4<C7CFF=@CC7C=EEA';@D566;@>B>AA?6;,'59&:?BD4:AB?
@2MJ
TTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATC
+
CCCFFFFFHHHHHJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJGHHIJIJIJJJJJJJJJIJIIHEEHHHFF7@EFEFEEEEEDBDEEEFDEE
@2MK
CACCCCTGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTT
+
@@@FFFFDBHHGHEIIECFFGGBGGHIIGHGHGIIIIIIIGIIIIGB;EIIHGHFHFDEFCD>CDCCCCCDDDACC@CCCC9ACDDCC@BCCCDCCDACCC
@2ML
GGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTC
+
@@=DDDDD>FHHHHHGEGIIIIGIGHIIIFHIGIGGHGGIIDHHGEIIIHEECGIIIIICHEFGHIIIEEHHEEDCCCCCAC@CA>ACCBCA@CCC@CDC
@2MM
CCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGG
+
@@@FFFFFHHHHHIJJJJJGIJGIIIJJIJIIJIJGFEHIJIIJJIIJGE5@CEHFFDD;<BDDD>>ABCCABD2??CACCCDDDDDDDDDDDDDCDDDDD
@2MN
ATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGA
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJJJJJFHIJJJIJJHHHHHHHFFFFFFFEEEEEEEDDDDDDDCDDDDDDDE
@2MO
TGCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTCCAAGTGAGGAGGCTCTCGC
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJIJJJJJJIJJJJGIJJIIIIIJHIIGGIJJJJJJJJJJJJIJIJJJFIIJJJHHHCEHFFEFDDDDDDDDD
@2MP
TTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAA
+
CCCFFFFFHGHHHIJIJJJJJJIJIJJJHIIJIJJJIJJJJJJJJIJJIIJJJJJIJIHIGGIJJJJJJJJJJJJJJJJJCHHHHFFFFFFEEEEEEDDD
@2MQ
TGGCTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTT
+
CCCFFFFFGHHHHIIJJJJJJJHJJEGIGIJJJJJJJGJJJJJJJJJIJJJIJJJIIJJJJIJJIIGJIHIJJJJGGGIJJHHHHHGHFFFFFFEEEEEEE
@2MR
TTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTG
+
@@@DDBDDHBADFD@@;AFGIIIBHHIIGIIGHGEIGIIIIIGIEFHGGHHGGGGHHGGEGG@FAEHEHEEACEEC?BB)58ACCCBBCCBBCBCCC?@B
@2MS
GTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCT
+
@C<BDDFDHGDDFDFEHEEFHGCEGHEHHAHBHIDEHGGEHGBABBBB@GDBFHGBF@@;4=.7@D@EHHAHBB>EC?@B@<<ABBB@B?BDDACDDDCD>
@2MT
CAACTTTTTCTTTTAGCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJJJJIJJJJJJJJJHHHHGFFFFFFFFEEEEEDDDDDDD
@2MU
CGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCC
+
BC<DFFFFHHHHGIIJJIJJJJJJJJJJJJJJHIGHIIJJIJJDFBFHIIIJJJIJHIJJJJIGIIFIIHHEFDDEEEDDDDDDDDDEDDDDCDDDDDBDD
@2MV
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCC
+
CCCFFFFFHHHHHJJJJJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJHHHFFFFFFEEDD9?B@DDDDCDDDDDDDDDDDDDDDDDDDD
@2MW
GTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJHIIJJHIHIHIJJIJJJJJIJJIJJJJIJJJIJIIJIJHHHHHHHFFFFF
@2MX
CCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAG
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJIGHIJJJJJJJIJJJJJJJJJIJJJJJJJJJIJJJJJJJJJHHHHFFFCCDDDDDDEDDDDDDDBDDDDD
@2MY
CGGTAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGT
+
=@@ADDFFHAFADDFHEHHFHII>HICEGHHGIIGIGDHIIIIIHFCCCA@CDCCCCC>BACC@@BBC@CCCCECCEC::@@CCCCCCB>BBBCBBC<><8
@2MZ
GCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTG
+
?<<?D=DDHGHHHIBD>FAAE?A?C9???<<FGHCHG>FF<91D<0B9BDGC2@@@;FHIIGH@EACECEEEFFFDC>;A>@?;((,5@:533(5>5>:
@2N0
GTGAAAAAGTGCCTTGAATGTAATTTGCGCAGAGCGCAGGCCTACCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAA
+
CBCFFFFFHHHHHJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJHHHHHFFFFFFEDEEEDDDDDDDDDDDDDDDDDDDDDDDD
@2N1
CATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGT
+
@@CFDDEDFHFHHJJJJIIJIJIJJJJIIIGIEHJJIJGIIIGFHIIIIIGHIIIIJIJJEHHIIGGIJHHIGIIJIHHHHGEFFFFFFCEEECEECCD=
@2N2
CTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTG
+
CCCFFFFFHHHGHJIJJJJJIJIIJJJJJIHHFFDEEEDDDDDDDDDDDDDDDDCDDEEEDEEDDDDDDDDDDDDDDDDDDDDDDDD?CDDDDDDDDDD>C
@2N3
CTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGCAGCAGACAAACCTGTGGATGATCCTCCATCAC
+
;=?D?1D;DD>+<<?EEIEFBAE<,+++9A9:C:?D)1:CD4DDDEC?9?9D<D48?*8(((''''&&&0&2<13+23<><>8++(((++(4>::3(:>AA
@2N4
GCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCT
+
C@@DFDDDHFCFAFDAFDDCDEI>C?FHGGHG>FH<E?<DGG)8779CC>CADA@@@CDCCCC:A@??3;B?@@B0<@>ACC@?C>:>CCACCBBCCC@<<
@2N5
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
@@@FDDDAFFBHHGEEEHIIGIGIFHGFHIGC>FDEHGEHFFDCGFHIIJIIECC@ECCD=CCA,9>?CC@CCA?@B??>ACC4@A:CC>C??<99<?CCC
@2N6
CTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCG
+
<<;DBDDDHAF?D<GED@FGIGBCHFFGDB9?B<D@FD8BEFGDGG;)=C@=E:A@B@BBCCC>A?<@@@BCCB?5>B@>@9ACCACDCCC@@?:ACBCB
@2N7
GAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGG
+
??<D?DADDD>FD?EDFGHGIDGGIIIGDD>HHIID>-<<@FH9@@FG=@DDDHCCCE@DECECCC@CCC;>>?=(88?>A<?>05-8>A?CC@CC28?5>
@2N8
GTGGCTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGG
+
CCCFFFFFHHGHHIJJGHIFHHJJJJIJJJJJJJHIJJJJJJJJJJJIIIJJIJJJJIJJGGIJJJHHHHFDDBDDDDDDCD@ADDD@CDDDDDACDDABD
@2N9
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
?;1B=BDD???FAEAAEGCEH9EAC9FCGIIE?@EH(9BFHGD==CFDHDBE=AA>E;2;CDCCAC@C@3;;?BCCCCCA>A@3:5>CCA:::@@CC>>@C
@2NA
GCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATG
+
CCCFFFFFHHGHHIICGHJGHIIGHIGGICFHIJIIJJJJJJJIIHIJGGIIJJGIHBCDDDDDDDBCDCDDDDECDEEDDDEACDACCCDEEDDDDDDEE
@2NB
CTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGG
+
BCCDFFFDHHFFHJJJJJIIIIJJIIJGIJIDFHHIIJJIJIIGIJJFHGIHJJJJHHFFFFFFECDDDDDDDDDDD?CCDDEDDDDBBDB9>CCCCDDD
@2NC
CCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCC
+
@@@DBFFFHDFFGIJJFCFIHFGIIHIGGGGHIHGIIEHHGIFGHGHGIJIJIIGIIIIJIIHCEDFCHII@DEHE7?A>DBAAB?@C>>CDE@>ACDDB?
@2ND
GTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGGGTTCTG
+
?8?DAD8@DAHF@9CE:ECCE9FHEHIGBC>H<FHC8=BBCFGGA@==@EDEEFEHE?;;CCEEC:3>;@AA@CAAC>AC@@=85>?CACC?A>(0<9?AC
@2NE
TATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCC
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJJJJIJJJJJ@FHIGHIJJJIFHIJJJHHHFFFFFEDEEEDDDDDDDDDDDDDDDDDDDDDEDDDDDDACCDD
@2NF
ATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTG
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJIIJJJJJJIJJJJJJJJJJJIGHIJIIIIJHHHHHHFFFFFFEDEEEDDDDDEFEEEDDD
@2NG
AGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTACCCATAGCTGCT
+
???D18DDDBD+CBEBEE9A+2<AFEE<EEC>DDEA9<?D@?DC;BD;?*?@C9=88;)=C=A4@-,4''5555-;(5<?2(',21<:>4<<4>>:>AAAA
@2NH
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAG
+
BBBFFFFFHHHHFIGJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIIJJJJJJJHHHGHFFDDDDDDDDDDDCCDDDEDDDDDD
@2NI
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
?@@BDAFFGHG?FGGDDCCGEHHIGIIGCHHGIIIIIGIIJIGFICHBHEGHGIGCEG>EHE7AADEDDFBDEAEE>AA@ACACACCAD<?B?BDDDD399
@2NJ
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@BBFDFFFHHHHHJJIEIJJJIIJIFIIIJFIJIIJJIJIIIJIIIJJIHIJJJJJIIIHGHIIIJIIHGHHFFFEEEEEEEDDDCDBBDBDDDDDDDDD
@2NK
CGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAA
+
@@;DDFFFHGGGHJJJIIJJGGIJIIIIJJJJJJJJJGEGIHIIJGHIIIJJIJJIJJJIJJJIJJJGHCHIJGGGHEHFHHGFFFFFFDEEEEEEEEDC
@2NL
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@@FFFDFGHHDFFIIIJIJIIJJIIIJJJGHFIHGIIIJJJJIGIIJJIIIJJIJGGIJIGIGCCGEHHHHFFFFFEDDDD>@DD8@CCDDC@CDDD@<B
@2NM
CAGCAGAACAAACCAAAGAAAAAGGAGAAAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAA
+
CCCFFFFFHHHHGIIJJJJIJJJJJJJIIJIJJJJJJJJJIJJJJJJJJJJJJJJHHHHHFFFFEDEEDDCCDDDD>ACDDCABDDDDDDDDDDDDDDD
@2NN
GTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCTATTGTGTTTATATGCACA
+
CBCFFFFFHHHHHJJJHIJIJJJJJJJJJGIJIJJJJJJJJJJJJJJJGIIIJJJJJJJJIJIJJJIIJJHHHHHHFFEFFFEEECEEDDDDEEFDEDD
@2NO
GCCGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATC
+
CCCFFFFFHHHHHJJJJJJJEHHIJJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJJJJJJIJJJJJJJJGJIJJHHHHHFFFFFFFEEEEDDDDDDD
@2NP
CTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTT
+
@@<DDADFHHHHHBDEDHGGCB>GAH1C@GFHGHGIFIFHHGAHBFDHEH>F@@FGH@ECE:??;@DCDCECAC;>A@BD@?CCDDD>C>@@CDCD>CCC@
@2NQ
CCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCA
+
:::B?B=B=DFB?<C<<CEBBDI@CD@DEHBAC@EFGGG<H9CGFA?B@?BB?DHDBB?DDB@GIGIGFF=F9FCCD@@AHA>A?D<;;;;A????;>>
@2NR
CACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAG
+
CC@FFFFFHHHHHJJJJIJJJJJIJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJIHHHHHFFFFFFEEEEDDDDDDCDDDDDDDDDDDDEDEED
@2NS
GGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTAC
+
@C@FFFDFFDHHHJJIBGIJHHIBHHIJJJJJJEGHHIHIJJFGIIIIIIJIJGIHJJIIIIIJJJJIIIJFHJIIJGAHEGAEHCDGEEHCHFFFFFFDD
@2NT
CATCCTCAACAGAACCAGAAGGACTTGAGTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCTGCATCTTCCTCCTCTTCCAAGGCCATGAGTCGCTTC
+
???DDDDD<DDDDEDEEIEI:+3AF9F99:?EEBDCC91?:)8DDECDC>BCEIIAC@AAD@@@AAA@>AA>;A>AA??AAAAAAA??><3>AA:4.59<9
@2NU
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
+:=?DDADBB>FB;BF9C>BF6??CBF*:*?*:D<D39B49<B2BC>>=CE@C';CA@?E3=C:BB';?,:335::<?52(4:@>3>4:>>3:?1&)&+(4
@2NV
GCCGTAATAAATTGTCGAAAATACCTTCAACACCCAAATTAATACCAAAAGTTACCAAAACTGCAG
+
@@CFDFFFHHHHHJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJIJJIIJ
@2NW
GTAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATC
+
CBCFFFFFHHHHHJIJJJJJJJJJIJHHJJJJJIJJJJJJJIJJJIJIJJJJJJJIHIJIJGIIIJJJGIJJJJHHHHHFFFFFFD;ABDDDDDDDEEDDD
@2NX
GTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCC
+
CBBFFFFDHHGGHJJJJJJJJJIJJJHHFHIIIJJIJJJJJJJJJJJJJIHIJIIIJJJJIJIJIGIJJJJFCEEEDEDDDDDDDDDDDDCDDDDDDDDDD
@2NY
CTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACC
+
?BBDDDEFHHGHHJIJJJJJJJJJJJIJJJIJJJJJIIFIJIJIJJJJIJJJJIGGIJIJJIFHIJJJGIIHGHHGHFFFFFFFDEEEEEDDDDDDDDDD
@2NZ
GGGGTAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGT
+
B@CFDDFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJGHIIJJJHHHHHHFFFFFFFEEEEEDDDDDDFDDDDDDDDDDDDDDDDDDDDDC
@2O0
GCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGT
+
@@CDDDDFHFFFHCBHGIIJIIJHGEFGHGIIGIGIIIJHFGJIIIGGIBDHEHIG9@G@DCH8@GGIJJHFEHC=C7?BB?CDDDD?<59B@CDC@CDDA
@2O1
CTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTT
+
@@CFFFFFHHHFHJIIJIJJJJIJJJIIIJIIJAGHIJCHGGJJHIJBFHIJJJJJJJIAHHHHHFFFFFFEEE>CEBDDDDCDDEDDDCCDDEEDDDDDD
@2O2
ATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTT
+
;@?ADB;BCADFH?@FGHGDDE?F@DH4AFEFGDGIIEHIHAF?GGEG?@F??>FDE<=D78=CCEHGCHEEE>EHA;7;@;@@>;;;;?B=?C>@>@>@C
@2O3
TCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGG
+
@@@DDDDDFFHFFGIGHE<CH9F@EGCHFBD@@EFHIGHIIEHGFIGGGHG>E=EG=EACEEDEBDA>CCCCCBBBBB<ACCDDCC>(55>BBAACCCCCC
@2O4
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
@@@DDB@DHFHFFIGGGHHHHGDHHHIIJIBFGEGGEGHHJHIIIJIJJJIJFHIFHHG=FGGA@EHHHFFFFFFFBEED@CDD;??BACDBDBB2<CCDD
@2O5
CCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJCGIJIJJIIJJJJJJJJJJIJHIJJJJJJJJJFACDDEDDDDDDDFDDDDDDDDDDDDDDDDDDDDDDDDDD
@2O6
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
C@CFFFFFHHHHHGHIJIJIJIJJJJJJFHIJJJJJJJIJJIJHIJJJJJJJJJJIIJJJJJJJJJIJJJJJJ7>DBDEECCEEECDDEEDDDDCCDDDDD
@2O7
GCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGT
+
@@@FFFADDBDFHJJFEGIGIGIGHGGIIIEJECGHGH@FGGHIJJGEGI>GIIIGGFEGGGHCHGI@CDCHCEHDDDD@BCCBD:>@;>CCABAACDDA5
@2O8
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFDDHHHHHJJJGGIJJJJIIGHIJJEGFEDFGHIIJIIIEIDGIJJJIIIJJJJJJJIJJJIJIJHHHFFAEEEEEEDDDDDDDDDD9ACDDDBD8
@2O9
CGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCT
+
CCCFFFFFHGHHHJJIJJJJJJIJJIJJJJJGHIIJJIIGIJJJJJJIHGHIHIJIIIIIJIJJI:=BDACDDEDCDCDDBDBBDDDDDDDDDDDDDDDDD
@2OA
CCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGC
+
CCCFFFFFHHHHHJJJJJJJJJHJJJJJJJJJJJJHIJJJJJIEHJJJJIIIIJJJJJJJIJJJHHHHHFFFFFDEEEEEEDECCDCDDEDDDDDDDDDDD
@2OB
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATAT
+
CC@FFFFFDHHHHIDGIIJIIJIHGIJJJJJIGGGEF?DDHG@FHIFHIIHIJIIGHIGIIJJEFFHGFFFFEDEEEDDB@DDCDDC?BABDBCDDDDDD@
@2OC
CCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGG
+
CCCFFFFFHHHGHJJHIJJJJJJJJJJJIJJJJJJJJJIIJHJJJJJJJJGIIJJIJIIJJJJHHHHHFFFFFFEDDBBDDDDDDDACDDDDDDDDDDDDD
@2OD
CTACTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCC
+
CCCFFFFFHHHHHJJJJJJIJIIJJJJJJJJJJJIIJJIIJJIJJJJJJJJJJHIJJJIJJJJJIJJIIJJJIJJIIJJHHHHHHFFFFFFEEDEEEDDDD
@2OE
AAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTC
+
@B@FDFFFHHHGHJJJJJJJJJJIJHJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJJJJJJJJJJHHEHHHHHFFFFFFEEEEEEDDDDDDDC
@2OF
GTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTT
+
BBCFFFFFHHHHHJJJJJJJJJIJJJJJJIJJJJDHHIJJJJJJJHIIJJJJHHHHHFFDDDDDDDDDDDDDDEED@CDDDDEEEEDDDDDDDDDDDDDEE
@2OG
CCTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGTGGCTCCAGT
+
CCCFFFFFHHFFHJJJJJHHHIIJJJIIGGHJJJFFHIJIJJJJJJJGIJJJIIGCEIJJJJJIIIJJHHEHHFFFFFFEDEDEDDCDDDDCDBDBCBDCD
@2OH
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
@@@FBDFFHHHHHJJGIJJJIJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJHHHHHHFFFFFFFCCEEEDDDDDDDDDDDDDDDDDDDDEDDDC
@2OI
CCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTT
+
?<@DB>DADFDDHH?F>EE>F?FBBHFHIEHGIIGGGI<FEEEHGGIIGGFGHIBDHGHI@BHGIICGH>CDGEGGGEAA?B@DDECCCACCCCCC>AC
@2OJ
CTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCT
+
CCCFFFFFHHHHFIJHIJJJJJJJJJJJJJJJJJJJFHJFIIIJJGHGFHGHIJIJJIJJJJHGHFGHFFFFFFEEED?CDDDCAAC@CDCCCDDDDDDDD
@2OK
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATAT
+
???DDB;4CDD?+++AA++3+:,<AEFIEDEI))1181:?DD962)9?D=DC?BB:B))8;=2A@).;@9=>C@..(;@3@;;.-;(;>>539,,,(,>:5
@2OL
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
CCCFFFFFHHHHHJFHIJJJFHIJJJJJJJJJJJJHHHHFFDDEDEEDDDDDDDDDDDDEDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@2OM
TTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATCATCGAGACTGCCGGCGAAACCGTCC
+
CCCFFFFFGHHHHJJIJJJIJJJIJJJJJJJJJJIJJJIJJJJJJJJJJIJJJCHIJJJIJJIIIIHHHHHHFFFFFFFEDDDDDDDDDDDDDDDDDDDD
@2ON
GCCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
CCCFFFFFHHHHHJJJJIJJJJJIJJJJJJJJJJJJJIIJJJJJJJJJJJHHIJIJJJJJJJJEHIIJJJJJJIJJJJIJHHHHFFFFEEEEEEEEEEDE
@2OO
CTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATC
+
@C@FDFFFGHFHDGBHIGIIIHHIIIIHGIICGGHGGIEGBHIBEGIIIIIIIIIIIIIG6CHGF):5?CFDDBACCB=CCDDBB??CCCDCCDDDDCCDD
@2OP
TATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCC
+
CCCFFFFFHHHHHJJIJJJJJJJJJIJIHIJGHJIJJJJJJJJJJJJJJJJJFHIDHGIJHHGHHHBEFFFFEEEEEEDCACDDDDDDDDDDDDACDDDC>
@2OQ
CCAGGGAGGAGGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCCCCCGCCATGAGCTCCAGCAGGATGAACCGGGGCAGGGAT
+
@CCFDDFDHHFHFGIEHGHIJIHIJJJGGBEBB55?CDDDDDBDBDBD?BDDCDDD3<CCDDDDB@DDDDDCCCCDDA@CCDBBDCDDDDBBDDBBBDDDD
@2OR
CTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCAC
+
CCCFFFFDHHGHGJIIJJHHIGGIIIHIJIGHJAHIGIIJIJEHIEGIGGGDFBFCGIIIIJJJJGIJJJGGHIIHGGIJIGIIJJHHGHHGE
@2OS
CCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTT
+
CCCFFFFFHGHGHJJJGIJJJJIJJJJIJJJJJJJIJIJJJJGGJJJJHIJ7DHIGIJHFDDEBDDDDDDDDDDDDEEAADDBBCDDCBDBDDDBBBDBDD
@2OT
GTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGT
+
@@@DDDD@DDFFFFHI<BHHHGHH@<FFGHIIB?FDFB>D?DBFBGE?BGGIHIIIGIF@GGGHEHFH:?CEBBDCC@>@9BCCC<C3+9C@@DDCCCCB@
@2OU
CCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJIIJJJJJJJJJIIIJJHHFFFFFDEEEEEDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDD>BBBDD
@2OV
TGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
??@ADBDDDFDFHIGCE>IGCHHF@HFHIIIIGHG;?DHEHGHAFIIII=@9DHCHCBEC;C===EDHCHEFBB3995?A@@@<+9>CBCCD@>@ACCA<
@2OW
CCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGG
+
@@?DDFBDFDBFBG@GHICD@HEHEEBEEGDGHGIIGHGGDFBBFHGIEBHICFBBFH;=FBFHIGIGGGDHGEIGEEGFHA7A@DF;7;;;;@;A;AC?
@2OX
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@C@FFFFFHGHHFIGIGGIJIIJIIIJHHGHIJJGJIIIGGIHIIIHHIEGGIHICFGGGEGEHIIIJHGGHFFDFEEEEEEDDDDDDDDDDDDCDDDACD
@2OY
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGG
+
@CCDFFFFHHHHHIIJJHIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIJIJJJJJDHIJIIGHHGHFHFFFFFDEEEECDDDDDDDDDDDD9>B<BD
@2OZ
CTTCCCTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTG
+
@@@DAADDHHDHHIGI@?AFEHIIGFGBGDCDBDGD;?;DFDGHIBHFBFIGI;FFEGGGGEAGGEE??BC3;?;>>@CACCACC?98<@BBB05@B9?A
@2P0
TCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGT
+
CCCFFFFFHHHHHJJIJHIJJJJJJJJJJJJJJIJJJIIJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJJGHHECEHFFFFFFDEDEEDCDDDDD
@2P1
CTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGGGCAGTGGCTGCTGGC
+
@@7DFDDBCFHFDH?EHCHGIIIIIGDF@9D?4:?FH@DHDDDBFBF@=CHDBF8FHCHICAHEEA?AAD@@B:>>3>@C<::@C(8=559>?B<?<>@C8
@2P2
CCGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@?=DDDDFDHHDFBBGI;F>FFHGEEG>CFGDHHIGEDGIIIIGGHIGIIIIGEFFF9BFCC;@CCCCCCCCCCC?CCCC@CBA@@CCCC(9ABCC8CC@<
@2P3
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGC
+
CCCFFFFFHHHHHHIJJJJJJJJJJJJJIIJIJJIIIJJJIJJIJJJJIJJJJJIJJJJJJ=BC>CEEDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@2P4
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
CCCFFFFFHGHHHJJIJJHIJJGIJJIIJJHHHIIIIIIIHIIIJIJIIIHIBFGIJIIIIGIFIJJHHHFFFFFF;@CD>CBD5>?BCDCDDDD<ACCDC
@2P5
CCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTG
+
CCCDFFFDDHHHFIIHGGJHEFHEHGGCHGDEEGHIHIHGIBFIGEB0?FAFEFFAGGFEHEGGIIJJGGGHGGFIGE=CHEAEHBDBDFDCC>CD>;>>
@2P6
CTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATC
+
@@@DDDD4DFFAFB;F1FC??F9<C2+CA?F4?9111?*:DGA6DD?00*?FB98D8===4)8==@;4=F4@4).=E><9',;@;;55>8=B:@D>>;::
@2P7
TATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJHIJJJJJJJJJJIIJJJJJIJJJIHIGHHHHFFEFFEEEEEEDDDCDDDEDDDDCCDDDDDDDDDDDDDD
@2P8
CTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTT
+
?@:DDFFDFHHHHIGIIJJJJJJIIJIIJJJJGIJJJGIIIIIIGHIIJJIJIJJFJJJJJGEGGIEHHHHHHFFFFFFDEECEEEBDDDDCDCDDDDEED
@2P9
GTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGTA
+
C@CFFFFFHHHHHJJJJJHIJJJIJIIJJJJIJJJJJJJJJJJJJJJJJHJJJJJIHHHHHHFFDDDDDDDDDDDDDDDDDDDDDDDBDDDDDDDDDD?C
@2PA
CTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGGGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATG
+
???DD?D:CD:CA@EEIIECFIDC;1FEEIEEBEFDDDDDA@;????35599<=>A>>A(8<0;2>:>4>BA>A><>A4>A>:3;9>>>:(:2(848>>>A
@2PB
CCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTG
+
CCCFFFFFGHGHHJJIJIHIIJJ<CEFGIJIIIIIIIJDHIIIJGIJJJJJJIJJJJIJIIGHHFHHFFFFFEDDDDDDDDDDDDEDCDDDD?BBDC
@2PC
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGT
+
?@@DDBDDBHFH?B@DFHEGACFCGH>9FCAHICHCFGIHDBBB@??6AH@=EDHED?CHHFF@>B@>=AACCC@??CCC(4+8?3239>>::>@@CCB?9
@2PD
GGGGGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGAT
+
CCCFFDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDEDDDDDCDCCDDDECDDDDDDDDDBDDDDDDDDDD@CCBDDCCDCCDCC@ADDEDDDDDDCD
@2PE
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
?:?DDDD?BDFAACCGIDFFCF??FHAHI?D?;FH>HFHAB>@CFFHD@@DEGAEEEEEEC@DDCCC@CAC>CCCCCCCCCADCCCA@CCCBB?<>BCCCC
@2PF
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATGGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGG
+
<@@DFDDADFHFDGEHEEGEHCHGHIDHIGGIEGGC;FGIIEF*BBAHABHB9?CE:;;@C@CCBAC5;;;>C?>(:>:9?@(4@@CCCCACCCC@C>>><
@2PG
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
CCCFFFFFHHHHHJJJHIJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIIJHHHFFFFFEEEDEEDDDDDDEEEDDDDDDDEEFEDDDD
@2PH
GTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGC
+
@C@DFDFFAFHDFGGGJGCGGGIHFHHIIIIGEBGIIIJJGJIJIJEHJHIJJIHHJGGIGJIJGIJJIJJHFHH>CDFBCACDDDDCCDDDDDDDDDACD
@2PI
TCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATC
+
CC@FFFFFFFFHGGGHIIJJFHIIJJIJIJJFHGGGGGGHIJFIHHIGGIIG<CFHIJJIJIJIEHIJGGEFGFFHFDEDDDDDDDDEEDD5>@CDDCDDC
@2PJ
TTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGAT
+
@@?DFFDDHDDDFH@GGGIIIGIIGGGGFEGCGII??<HEFBCGHIHGEHHIIIGGG@FHCHGGHIGGGBFHG8BF@@FFHIGGGIG==>ECCCEDCCAA>
@2PK
CCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTG
+
?@;DBDD@8CDFFIFI2AF>DHEIIEFDEGECGIIDFFEFIED?3BFFI@FEFACEIEFEFF=?B@@D>>CB@AAC@BBBBBAAB?A;>AABBB@B?@B?@
@2PL
CTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATAC
+
??<ADBDFDAHHFHGHH>EHDGBFE@EE?FHEGIIIDCGGIIII>FHHCGBD?DGCHIEAF@CHGC>;@CGGGDHII>CCAACEE@;BDC3;6;@A@@DEC
@2PM
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGT
+
@@?DFDFDDFFHHJJJHIJFFGIGJBDGGIIGHJIIIGEIDGIGIJIIJJJEFGHGGIHEHEFF?C@BCECCC@@AC>CCCDDDD9AACDDDDDCDCCCCC
@2PN
CCTCATGCTGCAGGTTGGTGAGCAGCTCGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGGTGGGATCCTTCAGGGCCTTCACAGCCACAAGCATCTTG
+
CCCFFFFFHHHHHJGHIJHJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFD@CDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDD
@2PO
GTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
BB<DFFDEHHGHHJJJIJIJJJJFFHEGIIJJJIGGHJJJJJJJJJJJJJHGIIIHIJJJJGGJJJIIJHHEHHHFFFCDEDDCCDDDEDDDDDDDACDD
@2PP
GCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFDABDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@2PQ
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
@?@BDDFDHFHHFACGAHGGIHIIEGGEHHIIIIICGGGIIIIGD@BFGIIIIGHHDGGHGIIIIIIHGCGG@=BEBDFEEDCDACCCC@CACD:>?AB?=
@2PR
TGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGC
+
=@<44ADAFHHCCF?DEFEFHF?FG@AHEGH@GIGICB;9DG?E?@FGEGIIDIICEE;CHHHEBECC@>C6>@CC@5@AA:;>CCDACA@CCC?<@?B?8
@2PS
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCT
+
???D=DDDHHHHHEIIIH@AGH<BHGEACGEHHE@EAGAFHIIIIIIIIIII<FG<FHIIIGHCF@=C@EH37))))7;)7?3(6>CCCC;5;(>C,89>>
@2PT
CATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGT
+
BCBFFFFFHHFFHIIIJJJJIHIIJJIHIIIJJEIIJIJJIJJJJJIJJJJJJIIJIJHHHHFFFFFFDD=?B@CDDDACDDDDDDDDDDDDDDCCDDDD@
@2PU
GTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
CCCFFFFFHHGHHJJJJJJJJJIIIIJJHIJIIJJJJJIJIIJJJIIJIJIJFIJJJIIIHHDHFFFFFFECEDDDDDDDDDDDDDDEDCDDBDDDDCCDD
@2PV
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@C@FFFFFHHHHFGIGGIGHGIJGFFHDDEHHFHGGIJIIIIFEGHIGHGIGHGHHBB>@CCF@CECCCACDCCCDDEDAACDDDD:ACDCC@ACDBCCC
@2PW
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
@@@BD:B@B2:D?BGGIBF?CC?FHFCHIEIBGB08?9?D===FBF/@F;F;77D7AA>>E?BD;6(.66;;:>B(;53:@@(5><8@8?:@444::++4@
@2PX
AAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTC
+
@@?DDFDDHHGBHIGJJJIHIJGIJIII9BFDEIGCGGGIIHIIDGICHII7@B=BD;@DFEEEECDDDCCCCDDCD:@B(5<@<ABDDDDDDDACDBCCC
@2PY
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJIJIJJJIJJGIJJJJHIJHIIIJJJJJJJJCEHHHHHHFFFFFFEEEEDDDDDDDDEDDDDDDDEEDDDDDDDC
@2PZ
CTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJIJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIHJJJJIJJJJIIIIJJJJJJJHCHHHHFFFFFFFDEE
@2Q0
GTCAGAAGTTGGTGGGAGAAAGGGAAGTGCAGGGGATGGAGACAGGGCGGCACTAGGTTTCATGCTCATATCCGGTCCCGGCAATGCAGATGCTGTTTCGG
+
@@@DBDA?=AAC?C::FH?BBFGAAFH:CGAFBDE?08D;D8;=B;5(-,9;;C@5?,>CA>>CC:44>C:>>BBBB<<5000&(++:@3@>C>:A@C>B<
@2Q1
CTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCAT
+
@@@DBDDDFH7FDIIIAC:?E?EGCHGHIGGGD@GGFGIGIAHGFHIGGIIG256?>@>;@D@@A>@CBC=A;ACB=@BBCCCCB><55>9>CCBB?CCCC
@2Q2
GGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCC
+
@C@FFFFFHDFHDIEGGIIIIIJJJJJJIGG?GHIGJJIIJJGFHGHJIJIIGIGHGG@GIJIHHECHEEDEFFFFFEDDDCCCDDDBDDD?C@BDEDDDD
@2Q3
CTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGG
+
CCCFFFFFHHDFHIJIJJJJIJIJJGIIIIJJJIIGJJJIIIJJJJJJJGHIIJJJJJJJEGIGGGGIJJHGEHHFFFFFBCEEEEEDDDDDD>CDDDDDD
@2Q4
GCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTC
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJIJJJJHIJJJJIJJJJJJJJJJJJJJJJJJJBHHHHFFFDEFFEADDDDDDDDDD?BDDDDDEEEEEEDDDD
@2Q5
CACTCCACGACCCCCTGTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCC
+
@@+=BDFFDFHHHIIIIIHIGFGBFGGHIIIIIIGGGGIIGIIHHIGGGIIIIGEIIGIGIEEHFHEFDFFD@CBA@B@ABDCDDDDDDDCCCDAACCDD
@2Q6
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATC
+
CCCFFFFFHHHHHIJJJJJJIJEGHHIIJJIIJIJJJIJJJJJJJJJJJJJIJHHGFFFFFFEDEECEEDDDDDEEFEDDDDDDCCDDDCDDDDACDDCDD
@2Q7
GGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTG
+
@@@DDBDDFHHHFGIGGIICIGG:FGG?ACCBGGGEHHGF@)??DDGEGGHHIIIIIIFGHDFHIIGBGHGDCHEEHGAACHEHHDDDEFCEECECEAEDD
@2Q8
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATAT
+
C@CFFDFFHDHHHGGHIJIIJJIIIJJJJJJJJJJIJIGIGIHGIHDGHIIFHIIIJIJIJJGHGHHHFFBCEEEEEDDBCDDDDDDBDDDDDACCCDDDC
@2Q9
CTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTT
+
@@@D;D?=ADHHDGCEBBEGB<I<CBGH?EHFHG?F@HFB<F??CGBF?BE9?D>D<DHFEGGA=FFECGEHIIDC@EEHHHHE8?BDCB>>C>CACC>A@
@2QA
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
C@CFFFFFHHHHHJJJJJJJIJJJJJIEGHHHIJJJJJJJJDGIJJJJJIJJJIJJJIJJJJJJJJIHHHFFDFFEEEEEDCCDCDDCDCDDDDD?CDDDC
@2QB
CTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCC
+
@CCFFFFDHHHHGIJICHGIIHEDGIGGEIIHGGHIHIJGIDGGHJIJHJGDGGFGI;BCFHGGIBGHGGIIHHHHFD?CCDEC@C;@CCAC>ACDDDCCA
@2QC
CGCCCATGAAGAGCAAGCCCCCTCCCACGTATGAGTCGGAGGAAGAGGACAAGTGCAAGCCTATGTCCTATGAGGAGAAGCGGCAGCTCAGCTTGGACATC
+
CCCFFFFFHHHHHJJGJIJJJJJIJJEGIFGHJGIGIIIGHIJJJHIIJIHHHEHHFFFFFEEDEEEFDDDDDDDDDDDDA?B@BDDDDDDDDDDDCDDDD
@2QD
CTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGG
+
@@@DDBADD<:?C?:::<IEEI9CBEHHI?9+<AEGF:)0?)*?DFFD@@=FB@CFGB;@=@7()...)=));@>>6@=B;@>35>;-;95<BBA>@A(9@
@2QE
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATAT
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJIJIGHJHHHHFDFFFEDEEEEDDDDDDDDDCDDDDDDD
@2QF
CATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCT
+
?<:DDADDHFDFDAFEHHH93AFFHG??C@F9C<FABGFGHA>GIIICDB<BFHHIDHE@FFBBDFEB?DBCGHGGIIIIGIIGIIIIDHEH=EH;BD@>C
@2QG
CCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
??@??D@@FDHHAGIGEBE?FG:6?DCFF3971BBCFB)).8=CH>:B;).?@7;CC@@C@'98;<ACCC@?<>:?(444@AB8@(9@>:A8<<(9?C3@(
@2QH
CATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGC
+
CCCFFFFFHHHHGJJIGGJIJJIJIGIJIJGHFIJJFGIJJJIIHIICGGIIIJJJJJJJJGGGGGIIGHIJIJIIIIJJFFEHGHJIHHHGGHFFFFFFE
@2QI
GTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACTGAATACACT
+
@@@DDDBEFHHDF4CEHDHHIFIIIIGIHGIGHIIIEHDFEGGIIIIIIIGBGCEHCHGIIGHFDHIIGGG@FGHGHIIEHHCE@;BEDACCECEEDCDDA
@2QJ
GGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGG
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJHJJJJJJJJJHHIJJJJJIJJHHHHHHFFFFDDDDDDDDDDDEDDDCDDDEDDDD@DDDDDDDDEDDED
@2QK
TCTACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJHHGHJGIIIIIIIIJJIIHGHHHFFDDECEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@2QL
CCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTGGGTCGTTGGGCATTCCGGACACCTGGC
+
BCCFDFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIIJJJJHHHFFBDDDDDDDDDDDDFDDDDDDDDDDD
@2QM
TTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTT
+
@7;?ADDDFHFFD@CHEGEDHGE>AGGGGFDHD>B?F:E9<?FH??CFGFDFFEBBGBBF@GDFABGGGGFGH@FFGHG@FHIA;=@@?CH;?AHDFCDBB
@2QN
CTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTG
+
@@8ADADDHHDDFGIGHICHGBCH?CGIGIEHCDDGI?FDHHCDFGDGGGGGHIIEH>=8CEHIDCH?CCDD@C>>B>BBBBBCCCCA>ACDCCCCCCC>
@2QO
ATTTCATTACACTGTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGG
+
CCCFFFFFHHHHHJHIJJJJJJJJJJJJJJJJJJJJJJJGGGHIJJJJJIJJJJJIIJJJJJJIJJJIIHHIJJJJJIHHHHHFDDCDDDDDDDDDDDDDD
@2QP
CGGCCTGCTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTTGACTTCGGAGCCATCTCTGTTTCGG
+
7@@?;8?BC??FFAGD:::IHFF+<C@F4?EFFFF?BF??:4BDF?FGII1?F@?;FFF':B;?1=@@ACBABB@;04>@:2-20083494:>A:@@>89
@2QQ
AGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTG
+
@@@FFFDDHFHGHIIHHB?EEFHGH@HHIIHGIIIIIGG?DHIGIGIHIGEIIIGEGIIFHCEFFEFFFDCEEEDEDDDDDD@CDDDCDDCCDDDCDDD9>
@2QR
CATGCGCCTATCATCTCAGCTACTCGGGAGGCTGGGGCAGGAGAATTGCTTGAACCAGGAGGCGGAGGCTGCAGTGAGCTGAGATGGCACCACTGTACTCC
+
B@+ADFFFHHHHHJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJIJIJJJJJHHHHFFFFDCDDDDDDDDDDDDCCCDDDDDDDDDDDDDDDDDDDEDEDD
@2QS
GTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAA
+
BB@FFFFFHHHHHGHIJJIIJJJIIJGIIJFIIJIIJJJJJIIIJJIGGIIIIIJJJIJJIJIIIHJJJGHIJJJHHHHHFFFFFFFEEEDDDDDDDDDD
@2QT
TGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACT
+
@@@D:3ADFHDBBGEDGIIIIEIIEHHIIIIIIIFH>@B<GHGGIGG<3?9;<4?DHGGGH>)=7D;)7??=CE<?;;?AC(;>AD>ACCCC@>C;@CC@C
@2QU
CAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTT
+
CC@FFFFFHHFHHJJHIJJJJJJJIJJJJJJJJGIIJJIGJJJJJIJIJJIJJIIJJJJJJJJJJJIIJIJJIIJHHJJGJJJIIHHHHHHHFFFFFFFD
@2QV
CCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAAT
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJIJJJJJIJJJJJJJJJJJJJIJJJJJJJIJJJJJJIJJIIHJJJJHHHHHF>CBEDDDDDDDDDDDDDDD
@2QW
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTT
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJHIIIJIIJJJJJJJJJJJJJHIIJJIJIIJJIJJJJJHHHHHFFFFEECEEED
@2QX
GAGCGGTCACCTAGGGAAGGCTTGGATAGAGTGGCCACAGGACCTCCTTCCCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTTCCAGGGGCACAATGGG
+
??;;4@DACFBFFIDAFGE?EEGEECFFIIIIDECFEE@F;?FBFFIFI@FDEEB==<@;>ACCB@BBBBBBBBB?BB9<ABBBB?ADB<<@>BBBBBBBB
@2QY
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
@?<DDD?DFDF?:3C:C,C?GF<CAD4<EGCFFFB?DFAFEFBGE@B?DABF>F<9DDF<F3=FF4;FCCE)>:,).?)66;;>>@@>BBB;;A??8<?6B
@2QZ
GCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGG
+
@@CFFFDFFDFHHIIJGIJGHGJGIJ??FA?FEHGHIFGIFIBBGGGGGEIHHHGGHCDDFFEEEEEEDDDDDDDDDEDCDDCCDCDCCDDDDDCDDDDDD
@2R0
TGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGG
+
@@@DDDFFHHGHHHIJIIJGIJJJJJJJJIJIJIJJFFIJIJJJJJJJJJJHHHHFFEFCABDCCDDDEDCCCCDDDDDDDEDDDDDDDDDDDDDDDDDD
@2R1
ATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJIIIHIJJJJJJJJJJIJJJJIJJJJGHIIJJHHHHHHHFFF
@2R2
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
@CCFDDDDFDHBDFGG@BFHEGHGADEFHIGAHHHHGGGB@DGBGGIGDGHGIGGIHIIE>E==CDFE@@DBA@CACCCCCCCCA@CCCA??BB@BBB35>
@2R3
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
CCCFDDBDFHFDHIJIHIJJJIJDIIJJJJJJIIIJJJGGGIGGIIFIJGIDFGGHIJFGJGGEHI.@DD;CHF(;?A6@CDDDD,9>>CDDDDCDDBDD?
@2R4
GCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATG
+
B@CFFFFFGHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJGIIJJJJJIHHIJJJIJJJJJHIIJJJIJJJJJJIJIJIIIJIIJIH3AHFHHFBEFFF
@2R5
CTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGG
+
@@@DDFFFHHHGHIFGAEGIHIGJJJJJJIIIGHIIIIHIGGIGGIHGCFHCH?BFHIGHIGIJJJJIJJJJIIFE=:@CECECEEDEDDCDCDDDD@CDB
@2R6
CTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGACATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
@@<BDD?;<?DBFGE@11?:EEEDDFBGDDFD@GBGHFGHCHBFDCAC<BCDGC?;D;DC)7=7=CHE;?;>>CCC.;??C?B@<CC5@CCCCCC@C3>:
@2R7
CATGTGTCTGTTTTAGAAGTGAATATTCCTTCCATGAAGGCCTCTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCCTCCCTTTCTATAGTAGCTCGC
+
@@BFDDDDHHFHHIIJIJJCIJJJJJJJJJJIJJIJJIJJJJJIJJJJJJJJJJJJJJJJJJJIIHHGHFFFFEEEDEDDDDDDDDDCDEEEDDECCCDDD
@2R8
TTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACC
+
CCCFFFFFHHHHHJJIEHGEHEHGIJIIGEIJJJJGGIJIIGIJGGFGIIIJG>FHBCGGBHGDCGIFHHHHFFDECDCCCEEDDDCDDDCCCDCCDDEDC
@2R9
GCCTGAAAGAACAAAAATGAACCAATGTTAAATGATACCAACCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAA
+
;=<D?DDDFFFFH@FB;@HA>A3FEEC<:E?CBGAFGDCDDGIEFGAGGEFGIIFGGIFFBFGEEHHGEECA7?EBDE>C<ACA;>>;C>CCCCCC@>CC
@2RA
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
CCCFFFFFHHHHHGHIJJJJJJJJJJJJJJJIJJJIJJJJJJIJIJJIIJIJJJJJJJJFHIJHHJH;CEFDFFFDED?BDDDCDDDDDDDDDDDDDDDD@
@2RB
GTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTT
+
?@8;;B;?C2+CD@>CDF?AF<:A;EGC??;F@?D?DFFI=??66@F@7@DCCDCCC>C>B@;?B;?CB:3/8=A@::3>A>434@@AB34:(:@9(49A<
@2RC
GCGTGGCTGTCCATCCACAAGGATCATTGCATCTGGCCCATGGGCCCTGAGGAACTTATTCAGGTCTCCATGCTTCATGTATTCAAAGACCATGATGAGGG
+
@@@DFFFFHHHHHJJJJJJJJGIIFIJIJJIJJIJEHIIJJIJIIJJJJGIGGIIIIIJIIJJIIGFFEEHFFFFFFEEEEEEEEEDDDDDDDDDDDEDDD
@2RD
CCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTT
+
CC@FFFFFGHHGHIHHHIIIIJJJJJJJJIJJJJJJJJJIJJJJJJIIJIJJJJJJIJJJJJIJEGIGIIHHHHHFHFFEFFFFEEEDEEEEEEEEDDDDD
@2RE
TAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGT
+
C@@FFFFFHHHHHJJJJJJHIIEFEHIJGGJGGJIIIJJIFHIIJJIJJJJJIIJDHIHHEHEFFFFFECCECEDECDCDDDDDDDDDDDDDDECACCBD9
@2RF
GTTCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACGCGGAGGACGCTGGGCAGTGATTAT
+
:::ADDBDBFFD?EAEGBCGCGGGI@FCD@BFGHHB0??DBCF>FHAGGFH/-'82'07A:><C<<?8>51&-9+2&))090&2?5>9@5(29-9AC>+4:
@2RG
GGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGC
+
@C@FFFFFHHHHHIJJJJJJJJIJJJJJJIJJJIJJJIJJJJIJJJJJJJJJIHHJJJJJJJJJJIJJGIIEHHHHFFFDDEEEDEEDDDD?BBDDB@CDD
@2RH
GTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGG
+
C@CFFFFDHGHGHIIICGHFHIJJJJJIJJJJJJIIIJJJJJJJJHGIIFJIJIIIJIJJGIGIJJJIHHHFDDBBCDDDDD4?CCCBCDCDDBCCDDDDD
@2RI
CTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTG
+
@<8DBEDFGHBHHIGHIIIIIIIIIIIIIGIIGIFHEEDHGI@GGIIIIIIIGFDHDFCEEFECDD;BDDDDDDDDCACCBDDDDDCDDDDDDDDDDDDCD
@2RJ
TCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTC
+
@C@DDFFFHHHHHEHICDHGICEFEHHEHIJIIJJFGIJEGGE@DDHEHGDGGECGBGGIJJIGEHGFGECCGHIIGCHHHHGECEFEFB@CECDCDEEDC
@2RK
GTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCT
+
@??DDDDEHFFH@FGGEFIGEHACFHHGEEFHD@GGGDEAEEHCHIEGHCEFHE@DFCBECACCABB>A??CCCC:@9@B>9>@BDDB@BDB@D>>>BD@8
@2RL
GGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCG
+
@@@DFFFDHGHHHJFHIJJGJIIJJJJJJJJJJJJJJIIIIJIJ?FHDFGIGHJJJIJJJJJJHJFCHIJHHGFFED=BBDDDDDDDDDEDDDDDDDDDD@
@2RM
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATC
+
BC@FFFFFHHHHHJCGHJIIJJAFHIIJJJJJJDGHJJIJJJJJJJJJJJJJJJJBGHIHHHHGFF@DFEEEEDDDDDDDDDDFDEEEDDDDDDDDDEDDD
@2RN
GCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGA
+
CCCFFFFFHHHHHJJHJJJJJJJJJJJIJJJJJJJJJJGHIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJGHHHHHFFFFFFEEEE
@2RO
GGTGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTTATTTTCTTCC
+
??@DDB?DF?<;:AFBE@BFBBHDIEH?F9CD@<C@C<?CAHGGII99?G9?D6BFCGBDDGG@;(;;-@@CA?)=?@DB?:@CCCCBBBBCC3>3@C44
@2RP
CTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCT
+
@B?DDFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJIJIIJJJJJJJJJJJJIJIJIJJJIIIJJHHHFFFFEEEDEACDDDEDDDDDDDDCDDDEDDD
@2RQ
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGTC
+
CC@FFFFFHHHHHJJJJJCHFHIJJJJJJJJIJIJJJJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFFEEEEDDDDDDDDDFEEEDDDDD
@2RR
TAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGG
+
B@CFDFFFDHHHDHHJHIJFGHIIHIIJJIJJIIJIHHJIJHHIIIJJJJIIFGIIJJIHHGFFFFFEEEEEEEDDDDDDDDDFDDDDCCCDCCDDDDDDB
@2RS
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
+=?==BDDHFFHFHH@GBGIHDGGGIFIIGGE?DHDBBEFHAFFHI>8FCHH;FF=FAHGIIH/?<ACACCCCBBBBBCC@CCACC:>(+8?B5<@@CCCC
@2RT
AGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCAC
+
@CCFFFFFGHFHHIJJJJJJJGHHIIJJJJJGGIJIGHIIJJIJIJHIEFEHGGCEHGIGHIHIIJIIFFH)?BBCFAEEEEEDABDDDDDDFDDDDDD
@2RU
GGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
@CCFFFFFFHHHGJCFHIIJHIJJJJGHJDHIGGIJJJJJIIJJJJHHIIJJJJJJJJJJJIHHHHFFFFDECBCEEDDDDDDDDDDDDDDDDDD>CCBCC
@2RV
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
@CCFADFFFHHHGIJIIJJGIJIJJIJIGIGGGJIGEGGIJJJIIIIJJJFHCEHIJJJIJJIJJEHHHHHFEFDFCECCDEDDD/=B<@CDDDCC@CDD
@2RW
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
@@@DDD?3ADDFDFBFEDHHDFEAAFFIIIEFIIBFAFFFDFBF@???F>DFE===CFFEIIICCAA3==@;@B?;A>>>>>A@@BB889@0>?:A::AA@
@2RX
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGATGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGG
+
@@@DDFFFFHHHHIJJJIJJJJJJJJJJIJIGJGIJIJJJJJIIJEHIJJJJJJIJJGJ@DHHIIJHHHFHHFFFBFFEEEEEEDDDDDCDDDDD9@B9BD
@2RY
CTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATACAAAATCTCTGGGTTCCTGTTT
+
?@;?B8BDFFB?DFHIIIICEGFH?C<CAE9C4?<DC@<DF>0:6BDD(?8DE9BB3=848).7=D>CE)7=EHFFE7;37)(.5;@>5;:@
@2RZ
CGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGT
+
CCCFFFFFFHHHHJIJIGHGGGGGIIJFIJJJJJJIIIGIIEIJD<GHDGIIIGIGHHGHIIIGGHHEE>EDHHFEECCCECCEDCCCDDDDDDDDCDCD>
@2S0
GCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTA
+
@@@DDDFDHHHHBHGDE@HHFICGHHHGIIGIII@GHD@AFHEGGIEGGBEGHIIHBEHGGIICGGGDEGHII@CECEHEHDEBDED6;>;@366>CB5A
@2S1
ATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATC
+
@@?DDDEFHHHHHJGHIJJJJJJJJJGHIIJJJIJJIJJJJJIJJIJJIJIJJIJJIJJJJJJJJJJJJJJJJJHHHHHFFFFFFD>BDDDDDDDCEEDDC
@2S2
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
@??DDD?DB8AFBFHB>FGGIGEFEHIB>FGGBE?@?FHA==F=CC7@A6C@=CEE==C=EHEED=?.;6;@C@@@A@;>A@(:?A@?88>C@@>@A:4>A
@2S3
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCC
+
?@@7D?BD<BFAFDAGGEFI>FHIIGECEHEEABCGGGHGIBGG>DFDACFHFGABC8BFG;=CHAHECCEF1=@ACECCCC;?BCBBCA>?AB9>BC@:@
@2S4
ATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATC
+
@BBFFFFFHHHHHJJJGIJJJJJJGJJJIJJIJJJJJJJJJJHIJJJIJJIJJIJJJIFHHIJIJJIIJIJJJIGHHHHFFFFFFECECCEEEDEEDDDDD
@2S5
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
?@?<?;DDGFDHHIGE:@GGHHBHDFECGICF@HE?FHBFHGHGFGFHGGGGGHIGBHHIG;DCBEF>BBCCCB>C6>CEBACCDDCCCCC:@A@CCCCCC
@2S6
CTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAA
+
@@@DDFFAFHABF?EHECAHCEFHBHIGHIIFHGBFGGGGIGIIIGDHI?FBGHICFGEHIEEHFG@BFADGFGIGGGCEHICEGCEE=CHHHGBEBEFD
@2S7
GCCTGGACAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGT
+
@CCFFFFFHGHHGJJJIJJJIIHIJJJIIIIJIJJJIJIIIGIBGHIIIJJJJIGGGIIHJJJGJHHHHGEEFEFFDDCEEDDDDBDCDEEDDDDDDDDDB
@2S8
CCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGCCAACACAGGTGTCATCATAAAACTG
+
=?+=:AD@0)C2<+:+CC?@:3;<DBDD@D:0(?*/8D)==CD93@=@CC;)=@CA)?AC>A;@3;(.6>>>33=(;5=55825=((+4+:4(:(4::>(+
@2S9
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
@@<DBDDBHHHHHJJFGGGIJIIIGEGIIGIEDFHIIGIGGGGGHIHGJIGGHAFHGIGJGFHH4=>>@ACAC>@B@BBDDDDAC@CC@CDDBDDD@BCC?
@2SA
GACTCAGTCAGAAGAGGAGCTTGGGGCAATAACATGAATTCTGGCCTCAACAAAAGTCCTCCCCTTGGAGGGGCACAAACGATCAGTAAGAATACAGAGC
+
@<8BBDEDDBDFHHGIGGIIGHJEEIEHGGGEEGHGIJIIIGIFG;FHHC@GHIJJCGGGIJIGIHH>?DB>C@@??BDA?@DDBCDCCDCACCCDCDCD
@2SB
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGT
+
BB@FBDFFHHHHHJJJJJIHIJJJJJIJJJIJIJIJJJJJJJIGIGGIJJIJIJJJJDDDDCDDDDDCDDDCDDECDDDCCDDABBBDDDDDCDCDDDDD@
@2SC
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
@@;DDDFFHHHHGGIIJEGHHHJIIJJJJIJJJJJIIJIJIJIIJFHJJJJGIIJ=FF@ECHFFHHHEFFFFF>AE;?B8@CDEEDDDDDDDDDDCDDDD
@2SD
CCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGC
+
CCCFFFFFGDHHHJGFHIIIJJGGIJJJIJJGGJIHIJJGGHIIIIIJADFIGHHIIIJJJHIICHIJJGIHIJJIJJJGAEHHBFDFFFEEAEEEEED@C
@2SE
GGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTC
+
@C@FFFFFHHHHHJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIJJIJJHHHHFFFFFEEEEEEEDDDD
@2SF
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGT
+
=B1ADDDFHHHHGIJIJJJJIFHHJGHIJEHIJHIIJIJIFGHIJHIJJJJJJJIJJJJJJJ=EEFFFFFEED>CEDDDDDDDDDDDDDDFDEEEDDDDDD
@2SG
GTCTGAGTGTCCTAATTAAAATCTATTAAACTAACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTG
+
@C@FFFFBFFHHHJIJJIIIIIJIIJIIJJJJJJIGIIJJIJJIIGGIIHIIIJJIJIJJJIJGIIGGGGIJIGIGHHHHHFDFFEEEDEEDDDDDDDDD
@2SH
GCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTG
+
@@@DDFFDHADFHIICFHHHGGGGHIIIIICFGHHIGGIHIIIGGDFHGHGHGHDGGGIHCGHIIIIEGGIHE
@2SI
CCGTCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGTGAGGAGGCTCTCGCACAGCTCCGCCCGC
+
??@DB??AAAADFGFHGGIGII@FEIIIEFHIEBFGGGIHBF@9DBFHIIGIIIGIIEEG7=@CE@HEFCCHC>CEEC?3==AA@@B=?BC@ACCBBBBBB
@2SJ
ATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAAC
+
@@@DDB:AFB?CF?:8:@DEA<A<CF@)9EFI>A>??DB<DB<FCF?A>BC=;;-(.7.7AEEFEBB7;5;@@6?;3',555@??A?4>A44>B?@7>+4@
@2SK
GCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATC
+
CCCFFDDFHHHHHJIIJJJJJJJJJJJIGIJIJJJJJGHIJJIGHIFIJIJ@HIIGIIIJJGAHCCHCHHHFB.=B?@B9?CDCCCDCDDD@CD@?B>CDA
@2SL
CTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
CCCFFFFDHHDHGJJJIIGBDDB?@CDDCCCCBCDEEDDCDCDD?ABBDDDDDDDEDDCCDDDDCDDDDDD@@B5>B<ACDDCCDD>CDDDC:ACDDCD
@2SM
GTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGC
+
BCCFFFFFHHHHHJJJIJJJHIIJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJIJJJGHJHHFHHFFFFFFEEDEEEDDDDDDDDCCDDDDDCDDDDBDD
@2SN
GTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTT
+
@@@DDDDBDFHFHJIGEEIHJIFGGGCIEGHIADHGIEGFGGGIGHIGIGIHJJJHGIIIHGBHIIIIGHIICHGGGHGIJE@EE?EHEDFCFDCFECEEE
@2SO
GTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCCGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTC
+
@@@DDFFFHDHFFHJJJJGGIJJJIJJJIIIJGIJEIJIIJIGIGJJGGIJIIJHIJIIIIEHHFECDFFDDDDCDDDDDCDDDACCAADDDDCC@CED
@2SP
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGG
+
@@@ADDFFHGHGCGHIGAFHJJIGIIFEGIJCHIGIEIGJIJFIIHIJIIIIIEBHGGI=CEHEIEEFEEHFFFFBDEEEEEDDDDCCD?BCDDD9<B5?B
@2SQ
CCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGT
+
C@CFFFFFGHHHHJJJJJJJJJIJJHIIJJJJIIJJJHIJJJJJIJJJI@GHIGIEHHEHHFFFFFEEDD@CDEEDCDDDDDDDDCCCDDDDDDDDEDDDC
@2SR
CTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGG
+
@C@DDFFFHHHGHJJJJJJIIJJJJIIIGHIIJIJJIJJFHJIIJJIJJJGIDGGHGIJJJIJJ@AEHHHEDFFFFDCDDDDDDEFDDDDDDDDCDEDBDD
@2SS
GCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTT
+
CCCFFFFFGHHHHJJJJJIJJGIHIJIGGJIJJJIJGIIJIJIIGGHJEGIHHJJIIIGHJIJHIJJGHIJEHFHHHHEFDFFFFDDD;BDDDDCCDDD
@2ST
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
?:=DDFFDHHGDFHIEHHFGHJIEGEIJJFHGEIJEGGHGGGHIIIJGGIJGHHHHHHHFEEFFEEEEEEDDDDDDDDACCCECCCDDCCDDDDDDDDDCD
@2SU
CCACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGAGGAAGTTTTCGTACCGGCTGTCAGAAAGCAACT
+
?;<1;D::DFFAC?FEE@DFED?@B<FGF3BB?<0?DD@??BF)/8AFC;@@F@D=@C;@?ACC;?B5'3==?-5(5:?<<B1955&0<AAAABA:(9??(
@2SV
TGGGAGGCTTGGGAAGCTTCATGCGCAGGTTCTCCAGCTGCAGGTTCTGGGAGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTACAGGAAGT
+
@@<DDFFFHHHHHJJJHIIJIJIJGIIIJGHJJJJJJJJJIGIJFHHHJJJIJGHHGHGHHFDFEFFFEEEEDCDDDDDDDDBCDDDDDACDDEDADDC
@2SW
CCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCT
+
@@;DDDFFGHHDFGIJGIJJHGHHIIGGHIIJJJIJ@GGIGGIJIGEDHIJGIICHFFDDDDDCDBCDDDDDDDDD?B<B@@CCCCDDDBBDDAC:@B>@C
@2SX
CTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACC
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJIJJJJJJJJFGHIJJJJJJIIJJJJJ;FHIEHHHFFFDFFDDDDDDDDDCDDDDDDCDDDDDDDDDDDDDD
@2SY
CCGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
CCCFFFFFHHHHHJGGJJJJJJIJJJJJJJJGJIJJJJJJJJJJJIJIJJJJJJJJJJJJJHH=BCCDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@2SZ
ATTCTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTT
+
@@;DDDEFDHGHHIIEHGIHHG@EFCHIIIIHIIGIGGGHIIIHGHIFHGIIIIIAGHHHEHFFFFECEBBBCCCCCBBCCCCCCACCC@@CCBB?B<CCD
@2T0
CTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGGAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCT
+
?;+ADB8?CB1+@@E@E>FEB9CD?E*?1DD))0BD))9BDA=8B38=)/)5;CAA).?).56((6(,;?9?9=(5>A>:,:5:>A>:44(00;>AAA3(+
@2T1
CATCATCATAATGGCTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAAT
+
@@?DDD;DFHHHHIGGGGGFHEFGIIIIGIFGHFEC9CGIDHECGGGGH?DFDFDGHGHIHGGCEFHIIJJC@GGCEHEEEBDCD>@C@EECACCCA>>AC
@2T2
CTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCT
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJJJJJJJJJHHJIJJJJJJJJJJJJIIJJJJIJIIJIIIJJJJJJJJIJIJJIJIJGHFHHHHFFFFFFFE
@2T3
CTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATC
+
CC@FFFFFHHHHHHJAFHIIIJIIBHCGIJIJIFIIHEGAFGIIIH@FGIG@GBHEDFEFHAACGBAHEGGGCGG@GIJHGGGHCCHEAB;?>CDDBCCCC
@2T4
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
@?8DDDDDHFHHHIIICGHIFHIG<EGHDGHIGII?FGGGHHIIIIIIIIIIIIIII;@AHFFHEEEEDCCCCCCBBBBCCCCCCECEEECCCCCCCCCD
@2T5
AGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTG
+
CCCFFFFFHHHHHJJJJJIJJJJJHJJIJJJJJJIJJJIGGIJJJJJJJIJIJJIJJJJHHHHFFFFFFFEEEEEDDDDDDDDDDDDDDDDDEDDDDDD9>
@2T6
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJIJJJJJJFHIIJJIJJDHIJJBFIIIJJJJIJIJIIGIJJJIIJJJJHHHHFFFFFEDDEDBDCCCDCCCDDDDCDDDCCDDDCDDD
@2T7
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@@?D??D?2?CDHIIEACADBF6<<2CBFGHIEEEGGHHAF*9BGGI<-.<F)=CFGEE-?)=7..7@?@DB(;?5>@?==38<@:@C@C<?4>>::ABB7
@2T8
TGTTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGG
+
@@1ADDDDHHDHHIJIIGGIIGEIGIIJIJIJJGJJJJJJJFGFHIIJBFHIIIJIIJIGIIIIHEHHEHHGFFFFDDEEDEDECDCDDDCCACCDD?BDD
@2T9
CTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATG
+
BC@FFFFFFFHFGIGHHGHIHGIIIJIIJIIIJIJJIJFHJGFHIHIJIGHGHIIIIIJIIIJ=CCHHJJHHGFFDEEEECF@BCDDCEEDDDEDDDDDDD
@2TA
CTGGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
:?14ADEFHHGHFIEGGGFGHIJFHGGCGHHIFHFIGGJJIJJGIIIIIJJAFCHCDGGIA?HHGFHFFFDDEA;ADDACDDEDEDDBDDDDDDDDDCCDD
@2TB
TGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CC@FDFFDHHFFHJJGGH<FDGHGIGIGHCHIDCGGIGGIGIHHGGHGIJIIJIGGIIHIGGG=?CEEHDFFDFCCEE@CCD>?BD8>??>CCDCD?2?A
@2TC
GTTTCGGTGTATAAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGGGATTTGGGCTGCGTGCAGACGACGGGGTTGGAAGCC
+
???AADA<<DDDD@ECEEAC3AFBBBFAEEEDAEDBFIIIBDD=D6?DDDCABA;@DDCD67AC>D(3>@AA?==;=?3=89A><???>?>?-9>9>>>88
@2TD
TGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@?<DDDDDADHF?BGEIFG<CFHGHGEGBGGIDFAEGGIAHGICCHDHGDFHCBBCFEBHGE>CEEEHE@BDCBCA@C6>CB;?BB,:?<5>CBABBBAC
@2TE
GTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAA
+
B@@DFFFFHHHHHFHEHJIJIJJIJJJIIIGJIIJJGIIJIJJJIIIJIJJJJJJJJJJJIIHIIJIJJGIJJJIEHHHHFFFFFFFEDDDDDDDDDDDD
@2TF
CACCCCTCTGGGGCTATCTAGGGCTTGCTCCTGCCCACCATGCACTTCTCTTGCCCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGCGGCGCCCCC
+
CCCFFFFFHHHHHJIJJJHIIIJJJJJIIJJJIJJJIJJJJJJIJIJJJJJIIJJJJIJJHHHHHHFFFFFEEEEEDDDDDEDDDDDDDDDDDBDDDDD
@2TG
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCT
+
?;=DDDFFHFGHGIAHIIIIF@DBHIIEFH@?@DFEEGIIIII>BF@HGIEAFC>EGEHGHEHF=B7;;;A@EAA>9=B=C@:A>A@B9@<@CCC>>AAA>
@2TH
GGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGT
+
@C<DFDDDFHFHHJJJJJJJJIIJJJI?EEDHGIJJJJHHIIJJIJJHIJIIJGIIHIIJIIJIIGHHHHHHHFFFFFFEEDDDDDDDDDDDEDDDDDDDD
@2TI
CTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCG
+
CCCFFFFFDHHHHJJJJIIIIIIIIJJJJJIJIIGIJJJJJBFHIJJJJJIJJJJJJEHGHFFFFFDDDEDDDCDDDDDDDDDDDDDDDDDDEDDDDDD
@2TJ
AAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGGGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATT
+
8?<DDD>D4DC8>@F@@EDHFHGI:F<FG>EE@?49?:)1:?8B<99*??<B*?DBFHC@ACFGG=@=@F:)==@GGCE3?>>EDC)?;?@;>AA;?@(;
@2TK
GCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTC
+
CCCFFFFFHHHHHIJJJGHIJJ<HHIJJJJJJJGIJJJJJJJJJIJJJJIJJJJHDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDCD:@B>@CCDD
@2TL
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATC
+
@@8ABDFFHHGHHJJJJIIIJJCGHFHGGGHIJIJIJJJJJJIIIJIIIIJIIHHGHFFFFFEEDEEECDDDDDEEDEDCCCDCCCCDDDDDDDDDDCCDD
@2TM
GGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFDFFDEEEEEEDDDDCACDEDDDDDDDED
@2TN
GCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
8?:BDDDD?C?BCGBAAGIIB@7:CCCCCC3>CBDADECA@A38??BB5@B?<>>AD>CCCACCCCCCCC@AAB@9<9?CCBC9?CA@C??CA44>>@A?
@2TO
CTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGT
+
@C@FDFFFHFHAFGIICGIHGIEGGIIJJJJGGEIIIGFGGGIIGIGIIIJIGDHIHHEHHGFFFFCCCCCEED>ACDCC@CDBDDDCCCCDDDDDBDB<0
@2TP
CTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCAT
+
=??DADDDDHHFHGIGEC:+<ADBEHHF<E31?9CFC?B9?BGAB>GHICGB=CHIECDHHIEHGE/=BDC;@@CCCC@C;@>??<?C@CB???ACA??@>
@2TQ
CGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGG
+
@@7DBDDDHDHFHIGGIBHHGGH@EEGHGEHIIIIIIIIIFIIIHFCCBCCEECCCCCCCCCC<8BBCCCCCCDCCEC:>CCC@CCACBBBB<CBCCCBB&
@2TR
CTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTG
+
@@@DFFDDHCFHHHIIJJGIJJIGEGFFDHIGBGHJJJJJIGIIGIGGHHIGIEGIJIJJIJJIJGGHFFFDDDEDDDDC@ACDD@CCBDDBDCDDDDBDC
@2TS
TAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGG
+
B@@FDFFFAFHHHIJJJJJHIIJJJJJJJJJJJJJJJJJJJGFHIJJJJJJJHIIJJJJHHHFFFFFEEFEEEEDDDDDDDDDEDDDEEDDDDDDDDDDDD
@2TT
CGCTAATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTC
+
CCCFFFFFHHFHFJJGIIIGIGHGGGIGHIJIIGIJJIJGGIGIIJJJJIFIJIIJIGGIJIJJGHIEEFHHHFFFFFDCEEEDDBCDDDDCEDDDDDDD>
@2TU
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
??=BBDDDHB2AFG?AFHIEB;?A<BCCG9CCGI@BH@GE9B:00?FH@/9BHIH9CF=FE:@>7C;=CHH;7;73@;;6;>>CA;@BBCBB??89028)(
@2TV
CTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGG
+
@@8DDDABFF?@DBG?=@A:EHED;3CBBHHIG><F?FGE'4;/-57=:=55-5-+::ACCC:@CA<57;@9>?BBB<B35-5-<B<@C@?B>9<BBCC
@2TW
GTAGGATCCAGTTTGGGGCGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
??7DAB>A::CB2<,+1@FD)@=A7=7?AA@?2>@??=?5>35(<>A>53333(+3:3+2((3>::A>>(+:>(43:>AA>>BA>>>A>:>>?8&&8:((+
@2TX
CCAGACAAAGGTCAGTGGGATTGTAACAACCAGAAATATTCCAACTATAATAGTAAGTATGAAACTTGTTTCTGGTATCCAAAAATCATCTTTCGGTGG
+
@@@DDDDBCCADABCHDBGGBGB2CHF9CEHDGFDD@CDHIAGHGHGDDGD@?09?<F>GBFADAFC@=FCH;@@.7@CHHFFBBEED@@CCC@??;?;
@2TY
CCTGTATGCCTGCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAAT
+
@<+=BDDDHFFF>BHHICFIIIIGIIGHGGIIIGIGDD?BGEIIIIGGGHHEBDEEEE@@CCECCCCCB@CCAB?=@<>ACCCCBCCCCCECACCCCDDCD
@2TZ
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCC
+
CCCFFFFFFHHHCGIIIIGGCEDA9CAAFHHGDA<?BDA@<DBDDHICGIGHGFGGIIGEHADBE@BCCCAC3;;8ACCC:C@B>BBCC:>@CC@>:CCBC
@2U0
CTCCGGTTCTCTCCTGGTCGGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHHHHHJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJHHHHHFFFFD9@DBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@2U1
CTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTT
+
@@@DD?DBAFDFAFEDH>FHE<ACHHEGH;HH<C9EGIIGBC?DDGIGGGHCF9<BDBGABCBFGH<8@FC7C@EHHH>C;==?DE@?C:@>;66A;5>>C
@2U2
CTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
@@?=DB+2AAF8F<E;1<:@B9?@@E@BCFFIAF<F@DA9C@<??BCBFC<?DF>>DF:AF;C@EDFCEEFF:C>BDDD>>:;BD:@BB3>:;=?>:8?>@
@2U3
CCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAAT
+
CCCFFFFFHGHHHJJJJJJJJJJCGHIJJJJJJJJJJJJJJJIJJJJJIIHJJJHHFFDDEDDDD?CCDEDDDCDDBDDDDEDEDDDDBDDDDD<BDDDDD
@2U4
ATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTC
+
CCCFFFFFHHHHHJJJJJJJJJGJJJJJJJJJJIJJJJJ?GHIHIJJJJJHIJJJJHHHFFFFEEDEEDDDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDD
@2U5
AGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
CCCFFFFFHHHHHJJJJJJJCGIGHJIIIJJJIJJJJJHHJDHIGGIIJJJJJJJJJJJHIJHHHHHHFFFFDEEEDDDDDDDDDDDEEDDDDDDDDDD
@2U6
TTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGA
+
CC@FFFFFHHHHHIIIIIIJJJJHIIIJJJJJIIIIJJJJIIIJJJJJCGEGIJJIJIJJJJJHHHHHHFFEFFFDDEEDED?CDDDDDDDDDCDDDDDD
@2U7
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGAC
+
@@@DAD4?CDCF<<FEG@GG@?<GFBDB1:E3CC*:***0??F<D<<9B=BH@FA8@;C;CG;;;4=;=AA).37?DAC:>;3>8(;;895(,)&+29?::
@2U8
GGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTT
+
@@@DDEFEHFHHHJJJJJJDGGFGIGIJJFIIIIJIIIJIJIJJJJIHGCHHFFFDFFE@?=@@=CCDCCDBDDDD9A(:?:>@CCDDDDDDDDDDDDDDD
@2U9
TGCAAATTCTCTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTT
+
CCCFFFFFHHHHHJJJIIJJJGIFHHFHHIIJJIJJIIJJJJJJJJJJIIJJJJJJJJJJJJJJIJIJJJJHHHHFGFFFFFDEEEDDDDDDDDDDDDDDD
@2UA
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGG
+
@@@DADDDHHHHHIEGIIBFGHGIIGGGHECBFGIIID@GCBFFEGGBIEHGAGICHGIIGEGIGEHHAHHE=>?AB6>??@B=@CCCCACCCCCCCC:?<
@2UB
GTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCC
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJHIGHIJJJJJJJIJJJJJJJJHJJJJJJJJJJJIJJIGHIIIJIEGIIHHHHHHFFFFFFCCEEEEDDD
@2UC
GGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCT
+
@@BFFFFFHHHHHJJJJJJJJJJJJJJIJJJIGHIJJJJJJJJIJJJJJIJIHHHFFDDDDDDDDDDDDDDEED:CDDDEEEEEDDBDDDDDDDDDDEEEC
@2UD
CTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCT
+
CCCFFDFFDFHHHJJIDIIGIJIJJJJIJJJIIJIIJJJGGIIIJIIJJJGIJJIHHHIIGHIJJJJ;BGGGGHHH?EEFFFFDDDDDDDDDEDDDDDDD
@2UE
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
BCCFFFFFHGGHHJJJJGHIIIIJJJIJJJJIJGHGHIJIGIHIGJIIGJJJJJJJJJHHHHHFFF9?BBDDDDDDDDDDDDDDDDDCDDDCDDDDDDDDD
@2UF
CTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTT
+
BCCFDEEFHHHHHJJJJJJJJJJJHIJIIIIJIJJJJJIFHIJJJJJJJJJJJIJIJJJJJJJFIJJJJIJJGIJJJGIIIJJJFHEHHHFFFFFFEEEEE
@2UG
GCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAAT
+
@@CFDDDFHHHHHJIIIIDGIIGIIIIIIIIJJJGGIJIJGEHIIIJIIEIJJJIJIJEHEDDFDEDCDDDBD?CDDDDDDDEEDDDDDDDDDBDBBBDBD
@2UH
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
?@7DDDDDHDDADGGGBG?FHICH<EGHHHIIIIGHIHIIEGIAHDAHGGIIGIIIGCBDCAGEECEEEECCCDDCC@CBBBBB<9BCCCC:CCCCB>@@
@2UI
GTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTG
+
@@@B;D===DB+<A:<AF<GIBCBG@?GB?999:DGIICDD@8?DDBF8/=88=.8@=C@@E8:557?;76..,3;?88/0052)+:A::::A4+225<50
@2UJ
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@@CFDDDDDHHHHJEIGIECFHGCDHHGJIJEIFGFGGEHDHHJJEHDHIEEGIGA=5??;@>C@CACDDC@?>>CC@CD@:@CACC@9ABC>@DC?<CDD
@2UK
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
:=?+40:@@ADDFFEEFGFI@FF?BBFFGCFEFAGB@FFCAB=FFDF=C;CF>7CEIFEFA?ADBD;BDDBC>>>;>B8?BBB@AAABA@BB:<BDB>@A
@2UL
CTTTCTGCCATCTCATAAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTT
+
CCCFFFFFHHHHHIJIJJJIJIIIIIJIHIIIIIIJJIIIGIC?DFGGIIGIJJJJFIFIJJJJJJJHGHHHFFFFEECCDACCDDDD?CBDEDDDDDDDD
@2UM
CTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGC
+
C@@DFDDDHDHHHGEGEHCHIFIGGGIHFIEDE??BFFGGDGFHIIIJIDGGA>*=FHI:=FFHADGGACHHH>?AEFE?BFDC;AE;=5>?BB9><9BC
@2UN
TGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTG
+
CCCFFFFFHHH:CFHIJFHIJJJJJJJIIGIIJIJJJJJIJIIJJFGIIJJIJJJJGHJJIJGHII7C=EHEHHHFFFDEEEDDEDDDEDDEEDDDEDDDD
@2UO
CACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATC
+
@<<BD=8AD1C@DB?FEHIGFHBEC*?DA?@?6D??8BCGDBFHIE;15@=@7?=AECB@?57638?B=B9BB::@@@>@@@CC:@CCCC9@@4>4>A4>
@2UP
GTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATC
+
@CCFFFFFHHHHHJJJJJIJJJJJJJIJJJJJJJJJJJJJIJIJJJJJJJJJJJJJJJIHIJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFF@DEEEEE
@2UQ
CTGAAGTCCTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCT
+
@@@?:ADD?FDDAHIIBDEEHEHCH1FB@<;EHH;?01)0??;.(;04=@@@>CC:=;7=AEF>)?;AD>3(..;>C;@B>CB(:@ACA>@C:<:(8?BBC
@2UR
GTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTT
+
<@@;DDD?DHDBDDGGBFFGGGEH>BGEEEGEBHGIGCDA>GHGGEFGBGF@D4BDGCGHHGGHGHHIIIIGGGFAEDE=A9=>A?A>C@CBBBB@<3<<?
@2US
GGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGG
+
@@@DDDABFFCFHIBGEGHAHIFHIHIHHEEFHHHGHGHCFCFFGHGHIAHGGHGEEAECBB<@B@=??89;5559@DBCCDECCACDC<<BDB9BDB@
@2UT
AAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTC
+
@@@FBDDFHHHHHJIJEDHIJJJJJHHIIGHIIIIGIJIGIIJGGIIIGIIIJJIJJJJIIGIGIEGIGIIIJFEEHHHEFEECFFFEEEEECCDDDDDDC
@2UU
CAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGACACCAAAAGACCATACATCACTTT
+
???BDDD:?DDDDAEE;EFFIIIIEIIIIDEEIIEIIIIEIDI;:;=CC>DDCDDD==@@?5;;@@AA?????????????<>><>><>?AA9AAAA>>:>
@2UV
GGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCG
+
@@<DDFDEFHHFHFGGGBHIIHGIJJBHGHCGHIJJJGIJJIJIDEHBGHGFHHGIGHJGIJGF>==ACEHH6B?DB=8?CDDDCCCACCDDDDDBBCCDB
@2UW
CCGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJFHIJJJJJJJJJJJEHIJJJJJJJJIIJJJJJJJJIIHHGFFDEECEDEDDDDDDDDDDDCDDDDDDD2
@2UX
CTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCT
+
@C@FFFFFFHGGFH:EGIIIIIIHIIIJJHIJIIJJJJIJJ?GHIJJJJJHIJIJIIIHIIGGHIJJJEGIIFHGEEEGGGHJIIGGAEHGFEE@BDCEE
@2UY
GCTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTGGGGGTCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCAC
+
@C@FFFFFFHDHHGJGGEEGHIIGIJIJIGHEGGIIGEDDGAFEHHGGHIGIJJCHGHEHEHED?DCDD6@@CCCC@B@?@CCACCC@CCCDC?BBBD@
@2UZ
GCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACAT
+
@@?DDFDFFFHHGJIJFGIIJIIJHHIGIJIIJJGI9CGGEHECGDHJJJG@GIIJJHJGGIGIIIIJJJJEEHEHIDHEEHFFFCDEDDEEEDDDD@ACA
@2V0
CTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTT
+
@@@DDBEDF>AFFIIIIHIHGHEGBHEFHDFGDFDAGHC;CGFBGG?FGC@@FBFFGBGGGHIIG>EEIGHGGHH>CE=;@CDB;CCEE>CCC@CCDCCDD
@2V1
GCCTCTTGACTGGCTTCAGGCAAGGAGGAGGCATCCTCAGTCCCCATGATAAGGAGATTGCCTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCC
+
@CCFDFFFHGHHGJIJJGIIGIJJJFIGGHEGIJIIIJJFDFGIEIGHJIJGGIJIGHHIEGIIJHHFFHHFFF3>BDDDDD??@CCCDDDDDDBDDDD
@2V2
GGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
CCCFFFFFCFFCFI?FGIEHEHIJJJFGG:DHDFHJJJJIIDGGJEIBCHIJIICHIIJJJIHGHHFFFFCDDEDEADCDDBDDBDB@@9@CCAC>CDEDE
@2V3
ATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGAC
+
C@@FFFFFFHGFHGHIIJGGBEIIGIIGIIJJJIJJJIJJIJJGGGCGHGIIHIIBHFHHCHHDHGBECCECGFHIGHIHHGFDECDFF@EEECECACDDD
@2V4
ATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCC
+
@@?FFDFFBAAFHIJBAGIGGHIJJGDHIBFIIGIJIJFJEGIGIJIHHHGGDFDBCAC;@ACDDBDBDDDDDCBA?BDDCCD@CDDDDDDDD@9@@BDBD
@2V5
CGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
@;?BBDDDCFHBFBEHGGI@@FEBFHGA*??FFDBFHIE=>D?@BDBFE>FHIIIFHFGIIIIF=CGGEFE(77;>>@@A=C@AC@CC9>>?:A?B+9?B
@2V6
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGT
+
CC@FFFEFGHHHHJJJJJJJJFHJJJJJJCHIIHIJJJJJDHGJJHIIJJJJJJJJJJJJJJEHHFFFFFDEDCEEDDDDDDDDDDDDDDFDEEEDDDDDC
@2V7
TGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCT
+
CCCFFFFFHHHHHJJJJIJJJIJIIJJJJJIJJJJGHIJJJJIIJJJJIIFGGIIIJJJJIIIGIJJH:BCD?CDDDCD>CBDDDDDDDDDDCDDDDDDDD
@2V8
CCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCT
+
CCCFFFFFHHHHHJJJJJJJIIJJJJJJJIJJJJJJIJJJJJJJIIJJJJJJJJJHIIJGHHHHHHHHFFFFFFDDCDDDDDDDDDDBDDBBDDACCDDDD
@2V9
GTTTTGTCTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCT
+
@@?BDD=DF?BAAFG@FBIFIIHFHI><CH@CHDC?CGH1?FHI@?B?B@GCFBFHBDF8BDAHGGIIIIADEGHHFECCCCCDDCCCCCCCCDCCACC5>
@2VA
CCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAAT
+
@@@DFFDDHHHHHGEFGIIIIIGHGEIGIJIJIJICHFIIGHGIGIEIGGGHBFGIJJGGC@FGGH@CHDEH7AEHHDDBEDCAD@BDCDDDCDCDD:@CE
@2VB
TCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGG
+
?@:BDDFFHGFHHJIIIJJJGIIIJJJIHIGGGHGIJJIEGDBGGHIJAFHIIJJJHHFFFFFFECCDDDDDDBDDBBCCDDDEDDDDDDDDBBCCDCCDB
@2VC
CCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAAT
+
@??BDDB=2ADBBHBGHEGGG9FH9F?<AE+AFA<FCHHH>FG9CBBGDGDG@FDC>GH4*09B?BFC8CF=F=CEF;F4=C;@77====>C?;7?@A);
@2VD
CGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTAAATAAAAAGCTTC
+
@@:BDFFFHHGHHIJJEGIIJJJJJJJIJJIJJJJJJJIJJJJJJJJIIJJHIIIIJJJIJJJJJJJIJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDD
@2VE
GGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCT
+
CC@FFFFFDHHGHJJJGHIIJJJJJGHIJJIIJJIHJIJJJJIIGGIJJFGHIHGIIJHHHCHFEFDDDCEDDDCCCDDDDDDDDDDDDDDDDDDCDDDDD
@2VF
CTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATATGGACAGAGTAAC
+
CCCFFFFFHHHHHIIIJIJJJJJJJJJJJIJJJJIIHJJIIJIJIIIIJJJJJJJIJJJHHHFDBDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD>CDD
@2VG
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@CCFDDEFDHFHHGFGIIGIIIII<EF?DGEF?FHI@FEHEFHIGICHHIGIIEEHHFFFFFFDECECCCADDDDCDEAD@C>CDD@CD@ACBC@@DCCD
@2VH
CTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTG
+
C<@FFADE?AFFHIFFHIIHHHIGIGHIIIGE@HGDEHGABD*?F>BFD>FHGBFCFGIGIC=FGGCA@ECAH;?>C>?BBA?=;@@@CC@?ACCC:@CCC
@2VI
GGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGC
+
BC@FFFFFHHHHHIJIJJJJJJJJJIJIJJJIJJIDGHIIGIJIJJIIJJJJJJIJHHGHHFFEFDDDDDDDDBDDDDDDDBDDDDDDDDDCBDDDDDDDD
@2VJ
TCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTG
+
C@CDDFDDGGFBHDHEHIIECFBFGHGHIIGIJFGGHBGGD@??FEFHAFGGIHGCEC;??BDDECC@CD(==?;8=9@ACCDC@>>><>CCCCCDCCDD>
@2VK
GTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGC
+
@@@FFFFFHGDFHIIGIIIIGCCGGHIIIIGGDG?BGBGIIGBBGH?F?DFHGHGHIGEFCEC@CGEHCEEABBEDD@CCEECCCCDD@=ABCCDDDCDD
@2VL
GTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTC
+
@@@ADADDFDFDFFIE:EGEAFHIIIIE?:2AFAC+8?:EF3))BGB<B@???<BFFDGG>DFAEFB3CFACE>FEED<?>=CBDDDBABAB>;>@>AAAD
@2VM
GCCGCTTAACTATCAAACGTGTCCATTAATTTTGCCGCTGAGGGTGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGGAAACCCAGTGTT
+
??1DB@DABF?DDFEF9GA<:<<<??CHF>CB<CB9??0D@FDF/7DC@B==FFCAFCCC)@AD;?AE>EE;;@;;??BC;AAA@B@B@>B@A?88<::;;
@2VN
TGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCT
+
@@1ADDFFHHHHHJJJJEHJIJJJJIJJJGJJHHIIIIJIJJJIJJJIHHIJGGIJJJGIJGCHFDDDDDDDDDDDDDEEDDDD9@BBDDDDDDDDDDDDC
@2VO
CATCTCTGGACTTATAAATGCTATTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTGAGCC
+
=?1AD?DDD?FAHIGBEA><CEEEG?FFD<4C@F>@DGCFGI9DG@D<4D>0BD<8B>B==CGCH4;;8CFH@@C=@AE==>A:@D6;<AB(=@>>:(:5(
@2VP
CTTCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCC
+
@@8=ADDFAHDDFFIJIIIJIHIJIJJEIGIJHGHIGJIIGBDHEGGIIIIJJGHJHDHGGDHGIIIGIGGGIHC?AEHHDFFFD>CCABDBBCCCCCD
@2VQ
GTTAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGCCCCATAGGTAACCCTC
+
??+4BADDFFFFAFDCFFGDECFFIEFFCHDBFBDGAFADCFDFFEIEC?DBDCFGEAFA@8=BFFIG;@@CEE7@C?=?AEE;);?@1665@5;>BBBBB
@2VR
CACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGGGCCTGGGCA
+
??1AD?3A+4::<EE;:+:3CE+4<+C48EDDCDD<4?*??D>9DDAD?@?:=8BC>CC7@CE;@;):''9/>@@???'8/:>>?(20+9()(8(((2<3
@2VS
GGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCT
+
?@@DDDBDHFHGGIIIIBH@GGGGHEIIIIIHGG>GIDGGGGGIIIGHIABDCBAACCC@@BBBBBBCCBCCCACBACC:A@C@A?CCC?@CCC@9@BBB@
@2VT
CTTACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGG
+
=?+BD?B>DDDD:C;<C;;+AFE<?@EEI:B@DD<DB3?D9DDDAADDDA7=;?;??A;@@DADA@@A?????;5<<7;>5>9;>3(:3:A>?34+><??>
@2VU
CTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTG
+
BB+ABDFFHHHHHJJJJJIJJJJJJIIIHHGIHJJIIJJJJJJIJIJJJIHIJIJJEGHIJJIIIHHHHFF>CDEDACCC>CCDDCDDDDDDDDDDDDDDC
@2VV
AGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGAATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGG
+
??14=B;3D:864':65;;;?B,,3;3379B>@3>8ABB1BB73559505((+9:(3(3@(+:3>:08>B9<:9A<3<A?:432<?882>AAABB?B((88
@2VW
CTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAAT
+
@@@DFFFFGFHFHIGAHEHGHIIIIFIIIII@HGHAHIIIIIIIIGDGCG9FCFDFHIIGIIIIIGGHEHHFFFFFFED@ACEECCDCCDC>CCDDEDE
@2VX
CACGAACCTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTG
+
@CCFFDDFHDHHGEIGIJJJIEFGGGJIJIJJJJIIJEGGIGIGIIIJJJJJGGIIJHHFHHHFDFDFFFEDEEEECDDDDDDDCCDDDCDDCC@CDDFED
@2VY
GTTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCC
+
?@:ADDFFHHHHHJIJJHHIHIJHHIIJIJIJIJJJJJJJJJJJJJJIIIJJJJJJIJJJJJJJJJJJJJJJJJJJJJHHHGHHHFFFFFFEEEEDEDDDD
@2VZ
GGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGATGC
+
=1=ADDDDHAHHBHIG>GIBEE6???CGDD9DGF?@GGBB3?9B9?BD<BB=8==5@=EHIIGC>ACACDBDC'3;;CC;5A:>::>>5:5?<<:@C14>@
@2W0
GTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTG
+
@@;DDDEDF@DBBHEHIIB@?@FGHC49D>D<?BDE<DGHBEGGIDGHGBCFHDGD;;=DDHCCEFECEC@D>;@>>A?>@A?=BBCB@=59+:>CACCC@
@2W1
GACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
@@@FDADBB?DDFGHBBGHIIGEB@BGCFHE8BFHD*877??FA88CFG>;=@=A>6?@DDFDECCEEECD>CCDDDCCACBACCD<A???8505<>A::4
@2W2
ACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTG
+
@B=DFDFFHHHHHJJJJJJJJJJJIJJJJJJJJJJJJJJHFDDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDCDDDDDDDDDDDDD
@2W3
GCCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
@@@DFDDDBFCFFHIDGIIIIGGHIECFGDEFI0?DHHGGE>FH;BFFH@F@GGIIIIDAHEFFFF<>BDDCCBDCB>ACCDDDDDBBDDDDDDDDCDDCC
@2W4
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
<@;DB<=<CCDAFHEAECHDAEHE@HGE@BGFHHICGGHGEE(??@B=CCDCHFC7@GA:E;=;,55B(66=>@;@ACCCCB?282<:>4:>CC>::@CAC
@2W5
CAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGG
+
@@@DFDDFDHHFFHIJIJEIJJGHHGGGHAGHIIDGGEDBGIGEEIDHGICEHGEFFFC>=;BDDDDCDCCDC@CCDDDD?8>BBDDBDDBCCCACDDDBB
@2W6
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
BB=DDEFFHHHHGIJFHGFGHHIFHGICGHIJHGIIIJJIIJJJJIIGFJJBDGIIJJJJGHHHHGEDFFAE@BA@CDCCCCEDDCDDDDDDCDDCDDDDD
@2W7
CTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
????;AAB3A<DDA@CEE:3<AB:A3<<9AAF;):EDI39DD?*BDD6DD<A8'5,9;A35;??<838=5((5-5&914>>>>:(3>A>:A>AA>AAAA(4
@2W8
GTATGCTCTTACCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCC
+
:11=+2BAF?:DAGEBAF@AEAAF@@?8?D?DFHFGBG@@:;@@EAGI=.=AHH3;B7?;6?=;5>C@C>C:8?2'9A::(9?<B<880<5<5AC>4>@?B
@2W9
GGCATCCAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGC
+
@78ADDDBB8???)2+CF8:CG<:?DG;BF4:*9DD?DFEFF=CFIAFAC7;5('?77=).).7?;76;;.;>A>>@/;:/5>AA?B2?3@A44::A:9
@2WA
CTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCT
+
=B1ADDFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHHHHFFFFEEEEEEEDDDDBDDDDDDDDDDDDDDDDDDDDDDDDEDDD
@2WB
CCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGC
+
@@@DFFFBFHHGHJIBHJIIFHEIJJIIJJGGGJJJJCGIFHIJJGHIGIJJIIJJGIFGHIHEHJIIECBBBCDDDCDDDDDDDDDDDDCDDD@>BBCDD
@2WC
GCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGAT
+
B@CFFFFFHHHHHJIIJJJJIIJJJJJJJJIIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJHGJIIHIIIJJJJJHHGEEHHFFFFFDEDDD;@BDCDDDD
@2WD
AAGGCTTTGTAACGCTGCCACTGACGGAAGTTCTCATAAACGTCCTTGGAAATTTTGGAGCGGTCACCTAGGGAAGGCTTGGATAGAGTGGCCACAGGACC
+
;@<D;ADB+22<<28C:8<FGBGH@11))011900:D??9DF98BFFB;3)88./@F<7CE6'=99@>(;A>;A;<((:535(+((4++:80<???2((2?
@2WE
CACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGT
+
@@@DADA2A22CFDDDFF=@FFI>@=CDEFB(;;?=B9;B@?<<'98??5?:@::@@95+:?>++-)0)8AAB4@3+4(8<BB@-0<@B?B@B??BBB@@(
@2WF
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCA
+
BCCFFFFFHHHHHJJJIJJJIJIJJIJJJJJJJJJDHIIJJJJIJIGIJJJJJBFHIE>CD@CGHFHHHFFDFFFFFFEDEEDDDDDDDDDEDDDDDDDD
@2WG
GTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAAC
+
CCCFFFFFDFHHHJIIJJIJIFIIIIIIIJIIGIIJJJJJIJJJJJJJJIJIIIJIIFHIIJIIJJJJJIHHEFFEEEEEDDDCDDDDDDDDDCDCDDCDD
@2WH
ATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGA
+
?@@ADBDEB?FFHIGIIGGHIGG>FEFGHFCFGE<G<CDHIIIIIIIICFBFCCFDHCBBCGAGG@ECFGHDDCHIIGFHA=E=BDC@CDECC>>@@@CC
@2WI
TTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTC
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJHHHFFFFEEEEEEDDDDDDDEEEDDDDDDDEEEED
@2WJ
CTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGT
+
CCCFFFDDHHGHHJJJJJJJJJJJJIIJJJJJJJJJJJJJJIJJJIJIJIJIJJJHHHHHHFFFFFFEEEEEDDDCDDBCDDDCDDDCDDDDDDD0<BDB
@2WK
CTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTG
+
CCCFFFFFGHHHHIJJIIIJIJJJJJJJJJJJJIJHIIIIIJJJJJJIJGIHIJJIIJJJJJJJJJJJIIIJJJJJIJIHHHHFHHFFFFDFFEEEEEEDC
@2WL
CCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGC
+
CCCFFFFFCFHHGHIGIJJJJJJJECCHGGIGIIGIJJIJJGIIJGHIGIJGGIIHHHDDEDBEDDAEDDDCDCCDDDDDDDDDCC@<CBCDDDDDC>CDC
@2WM
AGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATAGCAGC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJIJJJJJJ?FHIJJJJJJJJJJJJJJHHHFFEFFEEDDDDDDCDDDDDDDDDDDDDDDDDBDDDDDDDDEECDDCD
@2WN
CTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGT
+
CC@FFFFFHGGHHEHIJJJIJJJJJJIJGIJJGIJJHIJIIJIJJJJJIIJIJJJJJJJJJJIJJJJJJJIIJJJJJJIJJGHIJDIIHEHHHFFFFFFDA
@2WO
CGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTG
+
@@CBDDDFHHDDHGIIIBHGIDHGHIEFFHGIGIIIIHI@DHEADFBEDBDGGHGIIEEGHCEHBHH@7=C=DCGCCA?;?EEEEFD;;A>A>@A@@DDE>
@2WP
CCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTG
+
=:1A4++2@AC?DBEI@BE@ACFBDB?9CDDCB9DD<3??B??8?3=9==CEDD5><'..7;66;>??=AAAAA>5>AAA>9<>9;<<>:9:>>>:>:AA>
@2WQ
GAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCT
+
C@CFFFFFHHFHHJHHJJ<FGIIJJJJJJFHHIJIJJJJJJJJJIJJJJJJGHIJJJJJHHHEHFFFFFDDDDDDDDDDEDEEEDDDDDDDDDEDDDEE
@2WR
CTTGTGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJIIIJJJFIHHHHHFFFFFFEEEECEDDDDD
@2WS
CACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGCCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
??@DA?=@CC<FHBGD@FH<CEGCHIDE=;?@?68*?DD3C==;;CFH;=@77=':=?B@>;>;6(((55'389<C:AA3:><>>0:C:C@C81:>?:AC
@2WT
CCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGT
+
CC@FFFAEDHFCFHGIIGIIIIIIIIGGGIIIGEGIIIGFHIIIIHGIGEGEDHIIIIIHIIIDHHAFHI@AGGIIGCEHEHHHDFEFEF>@CEABDDDDD
@2WU
GGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGC
+
?@<D<DABFB?+2A:EGFFIHEFF>FHIIC@9AFG>FDAFIIC@FD309??GFCEGB>BD=CCFF8BC>CF:CCE>DEC>AC7)777?@BDDCC@B@5(>
@2WV
CTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATC
+
@@@DADFDHGHHHHEA@FIHHHC>FHGHIIJIJJJI>FGHIIIJGGGCGFHIHIJJJJJGIIEIGIJIJGHIJHHHGIJGH4=AEE>A?>DDDBDAD@CDA
@2WW
CTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCAC
+
=?@=A?DD:<DDFA?AGIC??AHBE11:CG@<FBG::BGG<9?9?9??9?FFF@8B88B<=FC=./87@E;7=E@7=C?E?E;).@B@?;A@>@>;AB@
@2WX
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJFHIHIJJJJJIJJJJJJJJJJJIIJIJJJJHHFFFFFEEEEEEDDDDDDDDDEEFEDDDDDDDDDDDDDDDDDDDD
@2WY
CAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTG
+
@CCFFFEFHHHHHJIJJICFHIIJJJJJJJJJIEHGIIIJGJJJJJGJFHIJJIHIGIIJGGIGIJIJJJJIJIIFHG7=ADDEEDDDEEDDCCDDDCDCD
@2WZ
AAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGT
+
@@?DDDBDD?F8?G:<CF4:CFF?EHC3A<E;:<C@B@HH>DG?@><DBBB9<=BF8@FCG;C=C3@@5?EC;;BACB;@C@BB2'9<<>-5>@9<5++4
@2X0
CGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCA
+
@@CFFFDDHHGHHIIIIIIJJGIIGHHJIIIEHIJJJJIJIIIIGGGGIGGIDGGFHHHHBCBBDDDBBDDBDDD@CCDDDDDDD@BDDBDDDDDDDDD
@2X1
CCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATA
+
@?;DDDDDHH>AF@EHEA?EHH@?A@AF9A<?ADH>H:0:@?09??99?<98?FB)BC=B4@FCFGGGA@@E==A>9;15BCB@;;@D@CCC5=C@C:@D
@2X2
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
@@@DFDFFHHHFHJCGEHIGFIJEIIIJIIJJJ@GIJJJJJIIIHIJJJJJIJJIJJJIJJJHABDACDDCCCDDDBDDDDDCDDCDDDDDDDDDDDDCCC
@2X3
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@C@FFBDFDFDHHGGHHHGGAEFHBEFH@EB?GEHIHEGCFCDF3BFG7=BB>FE;FAE5?=AH?BDD@@D?EBCCCCBB?3;@CCCCCCAB4:>>:>A@<
@2X4
CATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCT
+
<@;DDBEFHFDFFHGGEGIGCHHDIDEFHCHIIIIGEFGIGEF@GEAFGCGGGBD>F@FGBFGF=F=FFEBB@@AHEBEE>?EB37;;;;CEEEEA>;5;A
@2X5
CTCCACTGTGGGCTGCAAGCCTTCAATAGTCATTTCTGTTTGATCTGGACCTGCAGTTTTAGTTTTTGTTGGTCCTGGTCCATTTTTGGGAGTGGTGGTT
+
@@@DDDDBDF?FFHAFBHEGHIIEGHIHIIIIIIEFIEHIIIIIGGHIIIGHDGHHGHIIIIIIIIGACE=E;AEEE>D@D@BDDECCB@=88<BCB?B?
@2X6
ATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCTCTCCTCTCC
+
@CCFD?DFDDFHFIGIEG>HIGGIDHGHIIEIJIJJJIIJIJIJE>FGGIG@DGGDFHHECEEFEFFDCB;ACDCEEDDDDCDCCCBDDDCDCCA><CCC
@2X7
CTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGC
+
@@CFADDDHHD;DFHGGIHEIHEEIIGIEIIIEGHGHGIEGGIIHIIIIEGGIIIHEGEHHGCCEFFCCCEEFFCCFFCCCCCCA>>CCCACCCCAACCCB
@2X8
GCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCA
+
B@:BDFFFHFFHFIIGHIIJJJJJJJIIIIEHIJJGIJIJIIIJJGHIJJJJJJJIJIIJJJIIGIJIIJGIJJJJFHFHHHFFFFEEEEEEEEEFDDDD
@2X9
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
;?@D?DDDF<CBAGA?CBCEGCHFGBGIEIEH9?CDGGH@<F0?GGCG@FBGGIIHGBGGCGGE@CH:?;AHED<6?6>A>:>5>@@CCCCACACCCC>::
@2XA
CCCGGAAGGTGGACCTTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGG
+
CCCFFFFFGFHHHJJJJIJJJHJJJIJIIJJJJJHIIJJJJJJIJIJJIGHIJJIIJJJIIIHHHHFFFFDEDBDDD@CDDDDDDDDADDDDDDDDDD
@2XB
GTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAG
+
BB@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJHIIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJIJGHHHHFFFDEEEEDDDDD
@2XC
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
@@@DFFAB;DDFHFGHGGBHHCDGHGDHIIIIIGHGGHDBBFGDGEHICBDEFHGIFEHEHEHIIIECHIIII;:?9?CA>>>AACCCDCCCC@,:?A@<=
@2XD
CTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJIJJJJJJJIIHHJJJIJIJJJJJIJJIJJJJJJJJJJJJJJJJ
@2XE
GTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGA
+
@@@DFDFFHHHGHHIJJIIJJJIJIJJJJJJJIJJIJJHIIIIIIGIGIIJJJJJHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDD
@2XF
CTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTG
+
@C@FDDEFHFFFHIIIEHIIEHIBBGIGBCBDHHIIIGD>G@B?BFD@GGG-8;FFHEHGGB?A>C?BC@DFEDDE?@CCC??BB??CCCCBDCB@:AC@C
@2XG
TTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGC
+
CCCFFFFFHHHGHJJJGJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJIJJIHHHFDFEEEEEEEDDDDDDD;BDDFEDDCDDDDDDDDDC
@2XH
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAAC
+
CCCFFDDFHHGCFHIJJJJJJJJIIJHHIGHIJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJHHHFFFFEEEEEEDDDDDDDDDDDDDDDDCDD@CDEED
@2XI
GATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATT
+
C@CFFDFFHDDFFBDBHGGGFGHIGGIIGGIJGFHIIIGJJIGGICGEGIGHGIIJGDHJJIJFGHJEHFCBDFEED@@ACCCDCCDB>@CD>ADDDCACE
@2XJ
CTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTG
+
=BBBBDDDHHGHHJIIHJJHJHJJJJJJJGIGHHGGIJJIJIJJJJJGHIIJJGIJHGIHHAHHGHEIAGHGIIIIDHIHHHHEEFFFBCFFECEEEDCDC
@2XK
TAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCTATTGTGTTTAT
+
BB@FFFFDD6<BDDDDDDDDDDDDDCDCDDDDDDDDDDDDDDDDDDDDDBDDDDDDCDDDDEDEDDDDEDEEDDDDEDEEDDDDDCDDDEEEDCDDDDDD
@2XL
AGCCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTCTCTCATCCTTTTCTCTTCTTGCTTGTTGT
+
?@@;DDBD8=DFF9A+A3AF:<C@H?EB??C9?FBG1EBE4?:?:<40B<9B9*00BB@?B898?CD)BF)8=)=/874=ECF<;:=A?CD>);)7.6;(
@2XM
GTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGCATAATTCCTTTCTCATAGTAATAGC
+
BB?DDFFFFHHHHJIIIJJJJJJJJJJIIJJJJJJJJJJJJGIJJJJJJIJJJIIGIIJJJJIJJIIJJJJJJJJIJIJHJJJGIJJJHHHHHHHFFFFFF
@2XN
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCT
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJIJJJJJJJJJJIJJJHHHHHHHFFFFFFFEEEEDDDBDDDDDDEDD
@2XO
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@@@DDDFFHHFHHIJCFHJIIIJHGEHHGIIGIIHIGHHHDFGIFHGJ-BDH@FGIGIICEHGHHEDFFFFDDDDDDDDDD8=BC@CDDDDDACCCDDDDD
@2XP
CTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BCCDFFFFHHHHHIHJJJJJ@FHIHHIJJJIFHIJIJJJJIJJJJJJJIIJIIHHHHHHFFFFFEECEEDDEDCDDDDDDDDDDEDDDDDCDDDDBBDDDD
@2XQ
GTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTC
+
CCCFFDDDFADHFHCHGGGIJJIIJGIIGIIBHCFHHIIIHJGGHIIIJGIIEIGICHJFEHHGJJIGIIEHIEHHHFGFFFFCEEEEEEDEDCCCCADE>
@2XR
GGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGAC
+
@@@DBBDD+CDDCEDCGABIB:AFHH@<HCHHAHE@<?:EG<?CGFIFECGD@?B?BBBFDFCFFB=C)=FAFGEEAE@EAEF>2(7?;;BD3;A>6;?
@2XS
CCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATGACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGT
+
CCCFFDFDHHHHHJJJJIJJJJJJIJJGIIIIJJJIJJJJJJJJFIJJJJJIIHGIJIGIIIJJJIGGIHHJIIJIGIGHHGHFFFFFFEEEEEC@CCED5
@2XT
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTT
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJIJIJJIJJJJJJGGJHIIJJIJJJIHHIIJJIBHFFBEDDEEDDCBBDDDDDDDDCDDDDDDDDDDDDDD
@2XU
CTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATAC
+
@@?DDADDHHHHHIJJIGHFHIHGGGGIHIJIIJIIJEIJJJE@EFGIJFBFDEHGHGIGHJJJCHGGCHG@GGHIJACEEHEEDFCEFDCCEECCCEFEC
@2XV
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
@@;DDDD?DHHHFIEGIIGHHGIGEHIIIE<<?BFDDDDHGEHCAFHBB9??88=BCFDHCHHE5:9<>@A>CCCCC=5<B@BBBBCCCBBCACCCC@?@C
@2XW
CTCTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGGCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGCGTAGT
+
:=1=A?BAD?A3:?1@@CE<E4:CCDDE:?*?9**:40*)0(*(9B(7-@C3(.5().)7==C:;@7?=>;@AAA?7=>?1<5(,5;>>(:(+(((&))92
@2XX
ATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTC
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJJJHFDFFFEDD>@DDDDDECCCEEDDEFD
@2XY
CTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGT
+
?@?DD?DDHH<DFGAEHCEEEEBD@GGD<?@;??@FHDFDHGCHGHIFGFGCGDEDGBDE@9?@BCCCCCCDCECC?BBBBBA<?B@?5?8ACB>>@:@CB
@2XZ
CGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATAT
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ?FHGHIJJJJHHFFFFFEEEEEEDDDDDDDDDDDDDDDDCDDDDDDCDDDDDEE
@2Y0
GTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAAT
+
@C@DFFFFHHGHHIIIIJJJIGGIGJJJJJJIIGHIJJHIJIJIJJIIIJIIFHJIIJJJJJIGIIDHJIIJJCHIJIIHHCEHHHHFFEFDDDCCDDDDD
@2Y1
CTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATC
+
?@:DDFDFHHHHHJJJIHJJIJJIIJIJJJJJJIJIIIJJJGJJIIIJJJIIJIJJJIJIIJJJJJJJJJIEGIGIGHHFEDBEDDDDDDBDDDDDDDDD
@2Y2
CAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGG
+
?@@?D;DDDHHHBH@EGDF>DGC+A@G@EG<CF@G;BDGGAFDA@FGE>;EEHCHFEE@CDE@A@@>CCC@CA>;@A(<?BBCCCCB9A?@CCCBB55>@B
@2Y3
GACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@<DDDBDFDDBCGGIHIIGFHGGIIIIIGGGGGIIIIIIIIIIIIGIIIFCHGGEGGIEGIGFHEFDEDFECCEDDCCACCCD@BDDDDDDDDCDDCDC
@2Y4
CGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CC@FFFFFHHHHHCGHIIJJJJJIJHHIIIJJJJJJJJJJJJJIJJJJJIJJJJJJJJEHFFFFFEEEEE>CDBDDDDDCCCDDDDDDDDD9CCDDDDCDD
@2Y5
GTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTG
+
1=<?;;=A:222A4A3E8)@@@F?E@ECED?>D>)000***08;BDD>4)8BB<4@;;)..5;<8';;@DD;6;8>????>>0<9834:>44>>>8(5955
@2Y6
CAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATG
+
CCCFFFEFHHHHHIGHIJGIIJGHJJJIDGGIIJJJJIJJIJJJJIJJJJJIJJJHBCDEEDDDDDDDDDDDDEDDFEDDDEEDDCDDDDEEDDDDCDDE
@2Y7
CTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCT
+
CCCFFFFFHHHHHJJIJJJJJGIJIJIIJJJJJJHIIJIJIJJJIJJJJIIIJJJGHIIIFHIJJJJJIJJJJJJIJHHFDDDBDDDDDDDDDDDDEDDDD
@2Y8
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
C@CFFFDFDAFDFGIIGGE?AFFHIBGHEIIGIIIIIGGIBFGIGCGIHIIIIIG=FHGIGG@C?EE;EBBD>DECEDE6>CBCCBD(5<BACD?CDDB@C
@2Y9
GCAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAAT
+
@@@FFDDFHHHFFIIIJJIJJJJJJJJJJIGIJJICGGHJJJJIJJJCHIGIJJIGGHIJICFHIIJHIIGIIGGHHHHFFFFDFEECCDDEDDDDDEDDD
@2YA
CCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCTTGCCAGCAAAGCAGT
+
@@?DDDEDFDAFFBHDHEGHECHGEFBH@HGIBFHE/7=BCBGHIJGIDAEECDDDDBACDC@CD:@CC@C>CCC9<<08>DCCD>ACDCBCCCDCDCD
@2YB
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJIIJJJJJGIJJJJJIJIHIJJJIIIGIIGIHIJJ@EFDCCEEEDCCCDDDDDDDDDDDDDDDDDDDDDDDD
@2YC
CCGGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTG
+
CC@FFFFEHHHHHIIGHHHIJHJIJJJJIIHIJJHIJIGIHGIIJJJJEHIJJJIHIJJJJIJIIJJJHHHHFFFFDDCEECEEEDDCBCCCDDDDDEDED
@2YD
TGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCTCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCACAAATTTGGTCT
+
@@@DFFFDFFFHHGGGHIIGBBHIHIIIGECHGEGGG?@EEHGDDHIIIIIIGCFGIIGHFFGBA=FIIGGGEG>CGG@ACHHHEFCFDEFFACCCEE?C>
@2YE
CCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCACCTAGCCAAGAATGTCCAGGAAGTTTGGGGTGGCCTT
+
@@?D?D?BCFHDBE;AFCHIEGBC?E<?FB?DGHBBFGHDHII@HBHEHCE3(;;=6/9'',8(5253>>C:3(((+:+(4::9(2+(4>:()&))91(+4
@2YF
CATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATG
+
?@;;=DDD?F>@FA<<?:CG=@;?<GH><DCGFHDFHG<?B@AHIIGBB8?B@B;CG@GADEHH<65?C;3;>(;@;6@@@(55>CCAA@6?599<?(:>:
@2YG
GCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCG
+
@@@DDBDDHHHBFHIIGIJHGHJIIIJJJIJIGCFGIGFD@DHIFBFIJIICEHGGIIJGGIHHHHFFDDDECCD@ADDDCCCDDBDDDACDDDCCCDDDD
@2YH
GCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCG
+
=@+4AABDFFCHHAHEBE@IEFB?AC@FHDHEGIHG9EFFABB@9BDB?@FB<8==;@@CE>@=CHDEH=??CD?@C?CCCCC>C@;;>;@C<<<5582<0
@2YI
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGG
+
CCCFFFFFHHHGHIJIJJIJJJHGIJJJJJJJJJJGHIJJJJJJIJIJGHJJJJJGHHIJJJIIJJHHHFFFFFFEEEEDEDDD8?BDDDDDD@CCDC@CC
@2YJ
GCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGC
+
@C<DFAEFDHHFFGIIGIIGHJIGIGIIJGIJBEGCGHCFGHIJIJJEFDEA@=AFHDGGGHEHHA;CDFEDD@@CDDCCCDDDDDDCCDD>DDDBDDD
@2YK
AGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGGTACACTGCAGGTGGGTGGTCAGCTGCAACATGGCCTGG
+
@C@FFFFFHHHGHIJIJJJJJJJJJJJJJJJIJJJJIJJJJJJJJIJIJJIGHIJIJJJJJHD@DDDDDDDDDD9ABD5>BBDDDDDCDDDDDCCDDDDDD
@2YL
CCTCGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
=8+=A?;2@DDD8EEAEEDEFC>BFE=EIIDADDAD<?BD=.6B;C3@@C74)7?AD/4=@A(;>;5;((;88=???(4>::>>AA>::A<:><2:(9:::
@2YM
AAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGC
+
?<;?BDDAFHBBCCE?CB;?D?:67/9B?DB@CBB@CF@FA=C@C@@@C7..=??;>)?>3>A@C;;5>>>>C3@:@>><<8))+<AACC::>>:@:+42:
@2YN
TGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTT
+
@@@ADDEFHHHDHIGIIBEGIIIGIJIJJJJIIHGGJJGJJJIIJIIIJJJIJJIJDDBDDDDDCD:?CCDDDDCDD14>CDBB>B?BBCDCEDACDDD3@
@2YO
CGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGT
+
CC@FFFFFHHHHHJGHIJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJIEHHHGHHFFFFFFEEECEDDDDDDDDDDDDDDDDDD?@DB
@2YP
CGTCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
@@:ADDFFHDHHGJEHEGBHIJIIJJJHIJI)?FHHIJJJJJ8BDHEFHJJJIIJJJJICHGIH=BDFCFFDEEDDCDDCCBBDD?CCDDCCEDDDEDCDD
@2YQ
GCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
@@@DDDFFDDDHFHIBGHGHDC>GG?<?FFGFEHFHGIFBGFCHHFEBDFGGGGICAFEA@;DEECBD>BCCE>C;ACD>ABDB959<?>@AC?CC>@CA
@2YR
AAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTT
+
@@1BDDDFHHFHDHGHJJJJJJJJJJJJIIIJJJIJJIIJGIIGIIEGIIJHIIGIJIIJJGIIIIJJIJJGIIGIJHIIIJJHGGFFDFDDDDDDEDDDD
@2YS
CTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATC
+
???:A;DD?,<CDBE>E:FCCECF<:?CC<A?CCFA4@?@D>:9DDAD*0:BDD;DAD<D<?>9=BB8448A@A:)87ACI;=..=?CC>).?;.>6;;>>
@2YT
CACGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATG
+
=?1ABDD?FDHDDB?GIIG;FEFBFEGD<CBDAD@FEGGEE;F9DG?DFHHCAF@FGEGGGHIEFBHACCEEEC9>CCCCC(;;@CC>C;;@B09@??@@C
@2YU
CTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATG
+
CCCFFFFFHHHHHJJJCGHIIJJJIIJJJJJJJIIJJJJHIIIJJEHHHFFFFFFFCEEDEEDCDCDDCDEDDDDDDDACDDDBDDDDDDDDDDDDDDDDD
@2YV
TCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAA
+
:?@DA3?BDDA<F:CGIF<<<ABF+9?FFG:?;F?D9D<DG3?*??)..))=--'-(;)7??;;;).9,9=;A5:955(>?>BA&<<&00502((8202<
@2YW
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@@@FFFFFHHHHHBFHHEIGGGDGHGH?EEBFHIJIG4BFG9<DADHBFCHH@HCGGGGJIJJ@@EIEHGFFEB@@CA@>C@CDDDD9ACBCC@?(32?:A
@2YX
ATCCGGTATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTTGCTGGGGTATGGCAT
+
@@@FDF@DHHHH?BEGGIIEBGGGIEGIJJJGHGGG@GHIGEGGIGGIHHHHHFD;BBACEEDEDDDCDDDDDDCCDDCDDDDDDDDDDCDBD09CCDBCD
@2YY
CGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCC
+
CCBFFFFFHHFFHJJJJJJJEHGJJJIIJJJJIJJJJJJJGGHJGI?BDHGIIIIEIJIIJJIJJIEIGHHHFFCDC?BBBDCDDCDDDDDDCDDDDDDDB
@2YZ
GACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGCCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGG
+
@@@DDDDDFFFHAHGEF:F<G@HC?EFHBAGG8F><<27(-;8@EEEEEE@DEC;=C:>CB?8,8?C>>CCCCA8><>BB@<82:@@C:@ACCCCCC:>??
@2Z0
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@CCFFFFFHHBFHICHIGFAFHGHHJJGEG>DCGGIGIJJEGBFGGCHGIJJIDG;@EGG@?AA==?CBDECBC(;ACDDDD>:>:CD@CDDDDDC?:@>@
@2Z1
CCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTG
+
CCBFFFFFHHHGHJJJJJJIJJJIJJJJJJJJJJIJJJIIHIIJIJIGJIJIIJJIJJJJGHIJJJHBDCD;CDDDDD@CDDDDDD@DDDDDDDDDDDDDD
@2Z2
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
@C@FFEFFHHHHHJJJJJJJJJJJIJJGIIJJJJJJJIGHIHHIIIIJJJJJJJHHHHHHEFFFFFDDDD@DDDDDDDDDDCDDDDDDCDEDEEDDDDDD
@2Z3
CTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGT
+
CCCFFEA?HHHHHJIGJIIJDIIIJGIAHJGGIIIC>?FHGCFGBFDDGGIGDEHGCHGIIIJGIIHFHH@EEEDDFFCECECCDDDDACCDDACCCCDD:
@2Z4
ATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAAC
+
?::AD;ADF?:AFCEDDFCFG@@EB??C?BBG@?BB6D??698.8===7@.@3@;=7?EFFEBBBD@@@>5(,>;5;;@A<;?55@BBAB>@85022@AA3
@2Z5
AAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTG
+
;?;=DD;DF<+2AB?;ACGEECH7GF;GGED<<G4:?:??<DFD<B8??<9??==8CFEICD@@)..=76CEEAC3?;?@B>B@>A;;;BB@5;>ABBB:
@2Z6
CCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTG
+
@@@DDFDDFHFBFGIGIGIIJIGHGIGFHAHHIDHJIJJJJJJJJJIJJHJII@HIIDHHGGGIIIIJIIIIJGGEHGIEIIJHHHFHFEEDDDDCEEDC>
@2Z7
GGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJIIJJJJJJJIJJJJJJJJJJJJJJJJJJJFHIJIIJJHHHHFFFFFFEEDDDDDDDDDDDDDDDD
@2Z8
CCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCT
+
CCCFFFFFHHHHHJCGIJJJHIJJJJJJJJJJJJJJJJJJIJJJJJJJJIJHHFHHHHFFFFFDDDDDDDDDDDDDDDDDDDD<BDDDDDDDDDDDBDDDD
@2Z9
GTTCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@@<DDDDBBFDDF>FEDFEFCGF;BGE@<CFBFF@G9DEFFDF>0?GFFCFF9FGIIIII@AAFEEF/;<(?.;@@AAC>ABB>ABBB>AB3>B?(3<?:A
@2ZA
CTGCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTG
+
?==A=BD?:2CCCGIIA?CGG411?DBFI>B9BFAG@DF@FB;CDFFACE7@E=:B>C>;6;>;>5;58:@:5:@??:A?@:::2<5?9+(>+4::AB9)9
@2ZB
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
=@1=DDFFHHHHHIGGIEHIGHIJJJJIJIGIJJIJJJJJJJJJJJJIIIJIIIIJJIJJJHIJJJJJHHHFDDDDDDDDDCDCCDEDEEEDDDDCCDD
@2ZC
CTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATC
+
=@1ABDFFHHHHHGIIGIJIJJJJJJJJJIIJJJJGIIIJIIJJIJJGHIJJICGHIIIJJJIJ@GIIJIIIIIFHHHHHFFFFCDC@@CAECDDFDEEE
@2ZD
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJIJJJIJIJJJIJIJJJJIJJIJJJIJJJIIHHGHJJJ;ADDDEEEEDDCCDDDDDDDDDDDDDDDDDDDDDDDD
@2ZE
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJHJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJGHHHHFFFEEEEDEDDDD?BDBDDDDDDDDDDDDDDDDDDDD
@2ZF
GTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATG
+
@CCFDDDDFBDFFGFHHEIIIEHHIJACHIGHF@GGHIGEHEHIHHGGEHHGIIIIIJJJFB@@GGAHEGGGHACHEE?CB7?A@CAACDDDDBCC@ACDC
@2ZG
CTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCC
+
@@@;BDDD<<?D?C;CGI<EGB@EGCG?3?CFGBCC;?=C>(53<55>CCA59@32:(>3@3333>C22++4>C>900&5@(+48<<48((:A@<83834<
@2ZH
GCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCT
+
@C@FFFFFHHHHHJGHJJJJJJJJJJJJJJJJJJJIEGIJJHHHHHFFFFFEDDDDDDDEDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDD
@2ZI
GTCGTTTCTTCCTTCTGCCCGTGACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACC
+
@CCFFFFFHGHHGIJJGIJIJIJJJJJIGFHHIGJGHEFHIJJGIIIIJJIIGIHHHGFFFDDDBDBDCDDDDBDCA?CDDDDDD<BDDDDDDDDDDDBBD
@2ZJ
TCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTCCATGATGTCAACATACTCCTTCACAGC
+
CC@FFFFDHHHHHJJIIJJIJJJJJJJJJJJJJJJIGFIIGJJJJJBGIGIIIHHIGEGHIIIJJIIGFHHHHEFFFFFFFEDEDEECDDCCDDDDDDDDD
@2ZK
CAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCG
+
@@@DDDDAHF?DHBDEFGGIIIEIG>FEHIEFHICHHIIGIIGIID@FD5@FHAFGIBHFEEHEDDCA@@CEDCECCC??CCCC@A?A:>A:@CCCACC8
@2ZL
GCCAGCAAAGCAGTAGTTGGGGTTGTAGTCGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTT
+
@@@DB=D?FF3D?+<C<@EHGE)1C@F?CGBG?D6?<**8???A0A/'.7@BH68>@;;5(5;@>55,:>55>@>??(23:3:9>(:+>>:4:>A::??C?
@2ZM
GTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGG
+
@@@FDFFFHHHHHIIJJJJJJJJJJJJJJJJJJJIJJJJIIJJJJJJJJIJJJJJJJJJJJJJIJJJHHHGFFFFFEEEEEEDDDEDD
@2ZN
CGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
?@=DDDFFHGHHHJIIGHHGGCHHIBG9CFFCFIIJEHIJ@?9?FGGIHCHIJGIEIJIIIG>DCCEIE?<B;?@C;AA@BCDDACC?<AC@>CDB8>@D
@2ZO
TCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCG
+
@@:BDFFFHFHHFIGIIJJJJJJJEGHIIGGJJJIJJJJIJJGIIJJIGEEGBFFFCFFEHGGIHHHGHEGHHF?=DDDDEEDCAACDDDDBDDDDDDDD
@2ZP
CGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTAACCTGCCGCCTTAAATC
+
??@DDDDDHDFAHHIGIIIIEI@FGGGGIB@?<DCDH@GGFH@BDGIIIIIIIEIGGEGHE@CFH@GDAHGCE@EEEA@CCDCECCCCCC?>?@BBCCCDC
@2ZQ
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCC
+
@@@FFFFFHGHGHIIIGIIEBHEFGGEHGIIGHGIIIGIIBGIIIIIIIGIHHGHIIIEHGIIEIIHHHGGFDFDCADEDDDD@CC@AAACDDEDEDDCD
@2ZR
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGTAACTACAGTTATCCCCAGGTACC
+
CCCFFFFFFHGHGJIJJJJIJJIIJJJEFIIJJIJJIIJDHDGHHIIJJJJIJIJIIIGGIJJEHGJEHA;CCDECC>CEDDDDDCFDCDDDDDDDDCCDD
@2ZS
CCCATCTTCATCCTCAACAGAACCAGAAGGACTTGAGTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCTGCATCTTCCTCCTCTTCCAAGGCCATG
+
?;+A?DDDB?DB+3CEE?ED@:C?:ACC3+:E;CCDB*?9D4*?@D*9D6DA'8=88@A74@@>3(;,,339>AAAAAAA;:((,,,:(44>A(((+2>(
@2ZT
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
CCCFFFFFGHHHGJFIIJIJJHJEHHIIJJJJIGIGIJDGHIIJJJGHGIGIJJIJJ@EEHHEHFFFFFFEDDDEDDDD@BBDDDDDCDD@ACDDDDDDDD
@2ZU
GGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGG
+
CCCFFFFFHHHHHJJGIJJJHIJJJJHIJJJJIJJJJJIJJJJJJJJJJJJJJHHHHHFFFFFFEEEEEEDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDD
@2ZV
GTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTC
+
@BBFFFFFHHHGHJJJIJHIIJCGHJJJJIJGGHIJJIJJHIJJJJIJJJJIJJJJIJIIIJJHHHHHHHFFDDDDDDDDDDDDDDDDCDDABDDDDDDDD
@2ZW
TCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCT
+
BC@FFFFFHHHHHJJJJJJJJJJJJJJJHJJHFIIGJJJJJJJJJJJJJJIIJJJJIJJJIJIIIJJHHHHFFFFFFEDDEEEDEEEEEEDDDCDBDDDDD
@2ZX
CGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGC
+
@@@DDDDDD?<AC9CGAF@HHII@B?GHICH?FHFHCDFGAH@DB@9BGIIIG@F<FBC>C=CAHGGI@;CE;AHHCA>?DC;@A>@CAB?59;@@CC:>:
@2ZY
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
@C@FFFFFHHHHGJGIJJIIJIJJIIIIJJJJG0@DFGGGJIIJJICGIGIFEFHEFEDDCECEDDDDDDDBDBDDDDDC>CCCDCDCCDADDDDCCCDCC
@2ZZ
CTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGG
+
B@@FFFFFFFDHHIHIJJJIJIEJJJJJJIEGHGGGIIJJJIJIJIIIEIIJJJIJJJJIIIJJJJJJFHHHHHEDCEFFFEEEFCCCEDDDDDDBBDDD
@300
GTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGG
+
@@@D;BDDDDBFB<AF<CF@FHFHFIIIIIEGIC?E@FFFFEFIIFGFFEFIE@FC<FFECEFIFDEFEFFDBB>B3@BBBB(+:B4>BDBB>BA>ABBB>
@301
CTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTTCTGTACCACTTTTAGCAGC
+
?@?D1AD??=<AF<FDAFBHIIDH>>@BFC?C<9CFEDCFIIIIEF@FF<F;=F4FG:DEF475AEC?DDB@@AA@AAB@B<9@3(4:4(4+>44@?BBB8
@302
CGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGC
+
@@@FFFDFFAFHHIIIGDF@DHGFHGGHIIGHIECDHGGHIIIIGIICGHICCGGCEHHHHDDFC>BADDDB@BDCCCDBCDCD@CACCABACABBBD?B
@303
GGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGG
+
@@?DDDDAFHFDHJIHIIFHGGJGGE>EGCFEGEHGIGGHDHHGGHGHGIIIDGGHGDEHFBCCAEC?AB?AABD?A<?C:>@CD98<ACCCCDACDD?BD
@304
GGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTG
+
@C@FFDFFFHFHGHIJIJIJJJEHHIFFGI@CFGDGHIGGIFGHIGFHHGIJJJJJIJIJJJHAEDFFDDDEEDDDDDDDDDDBBCDDDDDECCCDDDDDD
@305
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
@@CFFFFFHHHHHJJJJJIJJIJHIJIHIHIIJJJJJJHHIIHIJJFHHJHIIJIJJCGHHHHHHFFFFFEDDEEDDDD;?@DDDDDDDDCDDDDDDDDDD
@306
CACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTT
+
@C@FFFFFHFHHHJJJJJJJJJJJIIIJJJJIJIGHIJJJIIIIJJJIIIJJIJGIIJJJJIIIJIIJEH@EHHEHIHHHHHHGEFFCDFEEEEEEDADDD
@307
GGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATT
+
BBB=DDDDHHHHHIIJJIJJJJIJHIIIJJJJJIJJ@GIJIJJJJJJIHHHHHHFFFFDDDDDCDDCDDDDDDDDDDD3@CDDEEEEEDDBDDDDDBDDDD
@308
CAGGGGTCTGAGCCTGGGTATAGCTGACATCAGTGGACTGTCCATAGGCTCCATAGCTTTGTTGCCCATATGCCTGGGAGGTCTGTGCATATCCTTGAGTG
+
?@?+A8D@3<:<ACF;E;FFG<9>4C>)?EF>GGF9*1*)*0:?4BBG9?87D<<)8=B>FFAFA))7=3==)..7?((('(.;=5(;;5;(:A::(:>>:
@309
CTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGG
+
=@1=BDDDHFDD@BECBEFHHFEGGGIIIIDHCH@DH@?BCC@;CFHHG@C@ECHH7;?<?@B?=CDC@ACDACCD<8<8@CC>>4>@>>++>><0?55
@30A
CTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGCGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTG
+
?@1ABD??F<CAFGFFDGFFCHEE::??EG@EFEFIIBFAE):@@FFE=DEECCEFEEFEFF@;;B?>@>?@@B)09>ABBB?@>:>AAAB9?BBBB>BBB
@30B
TTCCTATGGCCACCACTGTGCCACTTGGATGAAAATCTGCACAGTGTCCTGGTTCATCTACCAGCCTGGTCCATTCCAGCCTGTGTTCCATTGAGTTCCAC
+
@@8ABD??F?FDHGAHGFFDFGGBFBFG@>FGEE<B<F9FBBB3B>BD@BDG?DGIEG><DDHIIFGG<=DA@GGH>EACEB@;C?C>@CC:@((;@>@@C
@30C
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
@@@DDADDHFFFFJJIJIJIJIGIJIEIIJGIIIJJ@HIGJIEEDD?HGIIIIGIGIJJJEHEHBDDFDECECAABAB>ACCD>@ACACCCDCD<:>:39
@30D
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
BCBFFFFFHHHHHJJJJJJJJJHIJJJJJJJGHIJJJJJIJJJJJIJJIJIJJJJJJJIJHHHHFFFFFFEEDDDDDDCCDDDDDDEDEDDDDDDDDDDD
@30E
TTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGGATTTG
+
@@@DDDFD>FHDFEFHDFBIIIIIIBBHHHIHGIHGIG<@F????BGHGGIEBFCHII@DFGCFHIII<BFCDHGI;F@EHIIIAEH?B@@?BCCE;;ACC
@30F
CTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGC
+
@@<DDBDEHHGHHHIIGGIGGJIGDCHGIEIIIIIGGIJJJJJJBHIIGIDFEGGIIDFGGIIGIEGAGGHIIIJJJJJIIHHFHAEDDFDBECFEF>>AC
@30G
AGTCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACG
+
=@1ABADDBHDFHHE?@EGHFGGG>FHIGIC:DFHICHGEHICHEACFHI=DEHIHFFCHEEDEC:@(>CCCCBA>ACDCCCCAB??CCECCCDDCCCCCB
@30H
CTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCT
+
@@1DDFFFHHHHHJJEIIJJJHIJJJJJJIIJIIJIJJJJJJJJJJJIJJIJJIIIJIGIDGHIJIHIHGIJIJJJGHHFDDDDDDDDDDDDDDDDDDDDD
@30I
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
1:=442=B??FFHAE+2ACAF=E;FGGGG<9CBGA<GDH<B9?</9?>??4)8=;3=@;)).)).=)73(5)6'(6>AA@;3(;>(3/,'3@C>4:A4::
@30J
GGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGA
+
@C<DFFFFHHHHHJJJIJJJJJJJJJJJIJJJJJJIJJIJJJJIJJJJJJJIJJGJJIJIJJJGIIIJJJJHHHHFFFFFFEEDDDDDDDDDDDDDDDD
@30K
CTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCTTCTTCTGTCTCTCCTCGT
+
CC@FDEFFHGDFHIBGGIIIGIGGIJJIIGJGIIIGIJIGGIII@?FHGGGHIGGIIIJIJHHHEFFFFFFDCBDDDDDDDCDDDCDDDDEDDDDACCD>A
@30L
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
@@@FDFDDHHHHHIJJJJJJJIJFIGIJDH>GHGGHIGBFGGHFIJIIJIEEHFEIIGIIIHHHHGFECFDCCEEDDDDD?BB?BACDDDDDDDD@CCDDD
@30M
ATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAAT
+
?@@B=BDEHHFFHIGHIEIAEHCHID6DGHII?DDFGFGGHHEIGGFGGGE>87AG@D9@EGIGHGEEHFC?@DDDDABDDD@BCCCCDCCDCCDDDDCD
@30N
CATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACAAATCACATCGCCATCTTCACCTTCAAAGCTTTCATTTATGACTCCACTGTTGTTTGCTTCAT
+
?8?D??A=4DFBAFFEGBGCH@HGH>FH>HBHHDIDHIIFFGC@FA>?;FGDFF>FAHGHEHFGHEGGGA==AGHEECE7?=?7?C>@;AC@?C;>;>CC@
@30O
CCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGAC
+
=;<=??BD?AC<A?::E4IB:CFABB<CAFGIICEB??BD*1?<FG?GC@?BBBFFFDDFFDAGCCFFF4=@FFADA@CEE:7.7ABD>DD;?>>6;;A(-
@30P
CTCTGTTCTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAAC
+
CCCBDBBBDBCFHICEHBIG<@CEDDBHDB@@FDA:BG<????BBFHCDFH@=.8@==FHA@;?CEEEHFFFAADDCACECCA@DCA?;?BBCCCC@>BCB
@30Q
CTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATC
+
@@?ADDDDFDFD?@<8FEACBCH@@8DBGD?DG<BGCHDBB@BBDGG>@CAC@@;=CGDE=@=7==AHHB?DE;=CBB@8=?B<BB<@C@D@>?2?CA@C
@30R
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCA
+
CC@FFFFFHHGHHJJJFGGICFHFFHIIIIGIDIJFIIIJJIIGHGDGHIDDG0@CCCEHG;CAEEEHHFCDDFEFFDCDCEBCDDDBDDDEDDDDDDBD
@30S
GGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGG
+
@@;BDDDDFFFFDGG@EGIGHIJIIJBBDGFCHIIFIIGJGEIIHBHIJIIGIHFEFHFFFFF@CEEECCDDDCDDCDDECDDDDDCCBD?@DDDDDCDDC
@30T
TTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAA
+
@C@FFFEBFDFDHGHDGIGIJJICGHECFHGIGF9EGFIIGIGIFHIGCHHECAGEFHEIIIJJGHIIIIIIIIGFGGGGIIFJJIGHHHHGFFFF@DCE
@30U
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
@=@DFDFFHFFFFGGCFBGHIGGGGIHHIIIICGIIIIIGGGI@DGHGGIGE@;FIICFHIGGCGEGCEHGFFDFFFECCCECD@CBBDDDDD(8<B8?08
@30V
CTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTG
+
@@@DDFDFHGGFHGIHIIJIIIJGGIJJJIJJIJJGIGIIJ?FF@FGHGHGGIIIIDGIJHHFHG?EGIEFFFB=B?CDDDDDDCCDDCCDCDDDDCBDDD
@30W
CCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGG
+
CCCFFFFDDHHHHHIJGJJGIIGGGHGHEIJIIGFHIFJJJJIGIIGAFHGGGFGFBB7<BCDDDDCDCCC@;(8<@DC@CCCDBB7>BDDDDDDDDCCD
@30X
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
B@@DFFFFGHHHGFIJJJJJJIIJJJJJJJJJIFHGIIJGIGIJJJGIDIEIDHHHFEDDEDCECDCDCCDDDDDDDDDDCDDDCDDDDDDCDDDDDDDDD
@30Y
CTTCACCTCCAGCTCCAAGTAAGGTAAAGATAATTCCAGTTTGAGAATTTACACCTACAGCTGTAACTACCATTCTTCCAGAGCCTTCCATTACGTGAGT
+
@?@DDDAB?BFHHICFGIG4FFHG+AFABEHBEBH??CG9CAGHGD9?BBGGHEA>DFH@G3<8CFH7@FHIIDICGIE7==?EBDEDECEECC?B?=B>
@30Z
GTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCAC
+
B@@DDFFFHHHHHHIJJJJJJJJJJJJJJJJFIJIGIIIIGIIIJIJIIJJIJIHHIJEGGHGHIJJIIJGIIIGHHHHGHHFFFCFDEECEEDDDDCDDD
@310
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
@@@DFFFFDFDHHGBGIIIEFHGIGGGIHGIIIIIGGEAH;:?FGGIE?B?BGIHIGDDHADCBDHIIC;7CGE7DHEHHGHEEFF@CC@CEACEECCD
@311
TGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCAT
+
BC@FFFFFHHHHHJJJJJJJJJIJJJGIIIIJJJJJIJJJJJJJJJJJIJJJJJJJJJJJJJIJHHHEFFDFEEEEEDDDDDDDDDDDDDDDDDDDDDDD
@312
TAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGT
+
<<@BD?DDFAHAFGB:AEGIIGGIC<>FHHBHH>BF<D<91B<??BBG?FDBDF?D8?D>HBF;8C7CGEGGGEHCA7=;;@DC>:@>@CAC@?C@CD;2<
@313
CCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCTCC
+
@@@DAD?BFFHFFIII@FGDGIIIIIIIIIIEGGCEGDGHIEEHIIIIIIIIIGIIII8FFHCDGHHHHFHEEECCB@ABBBBBBBBB@CCCC@CCECC@>
@314
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJGIJJJJJHIJJJJJJJJJJJJJHHHHFFFFEEEEEEDDDDDDDBDDDDDDDDDDD
@315
TCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCT
+
CCCFFFFFHHHHHIIIJJJJIFGHIGHJJJJJJIIIJGJJIJJJJJIIJIIIIIIJJJFJGGHHFFFE@AEEEEEDEDDDDDDDCDDDDCCDCDDDDDDDD
@316
CGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCT
+
<?<B;DADFFD?CF+CCFECEFGGCGEHIEDHIICABFFFGIIHGBHCGFA@@@GCE?CEEDB=A@AA@CCCC3>CCCCCCCCB3@CCAC>B?B?B<B@:>
@317
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTG
+
?@;DDEFFHHHGFJEHHJIIJJGIGIFIJGDGHJIJIIIEDHBFFHIIGIIIGIII==CHHIEIHGFIJJJHHHGGHFDFEBDDB;;CCCDDD?BCCDDDD
@318
AATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTC
+
@@@DDFFFHHHGFGGGEHIIIHIJEFFHGEGIJJJJJHIIDGDGGEIIJIJ@FGIGHGIIHHBFHGBGGGEGIIIEECDECEFFHHFFFDF@CDEEDDDDD
@319
CCCGTCCTCACCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCTCATCAGGGTCTTTGATG
+
@?@DDDDDFF?F:EB@1)A;:DEF<@BFBFFEICF6=CF@FF7@C=C3:AA?>?;>BC>;8;8=68585?@?BB@<BBBB<?B8?:4>:AAB+9+4>((:4
@31A
AGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCT
+
CCCFFFFFHDFHHIJJJJJJJJJJIJJGIJGGIJIJIJJ9DGGJIEHGIJIIIIHGIHGGHIIIJJIJI@EHIDHHHFFFDFEDECACBDDDDBDBDDDDC
@31B
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
BB@FFFFFHHHHHJJJIJJJIIJIJIIJIIJGIIIJJIJJDHHIHIIJ<FHIGIJJJJJ@CHGGHFFFFFFDEDDCDDDDD@BDDDDDDDDDCDDDDDDDD
@31C
GCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTC
+
@<?DBDFFBADBFH<GFI>EIIIIABEBEFHFEEDAFFFHICHHHG>FH<B<DDEFHHICH:BFII=?BDEIGE>AEEDCGHIGEHHEH;B?3;;>@AC;>
@31D
TGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACT
+
@@@FFFFA=CFAFIGEGIGICFHGHGFHB;?FAAFFGGGFBDHG@GHBDECFGGIDHEEGHIIII9DHBHFEFB>;>AC?@B>>:@CACCDCCCCCB?C:A
@31E
GGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
CCCFFFEFHHHHHJJJJJJIJJJJJJJJJJJJIJJJJJJGHHIJJJIIJIJJJJJJJJJJJJJJJJHHFFDEECEEECDDDDCDDDDDDDDDDDDDDDDDD
@31F
GTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACT
+
@@?DFFFFGHHFHIIJJJJIJJJGIIJJJIIJJJJJGIJJJJJJJJJFEIJHJJJJJIJJJJIIJJJJJJGIHHEHHFFFFFFFEEEEDDDDDDDDDDDDD
@31G
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
CCCFFFEFHHHHHJJJJJJJJHIJJJJIJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJIIJJIJJJBGGEHHHHHFFFFFFFEEEEEECDDDDDDCDDD>B
@31H
CGGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
@@@FFFFFHGHHHGIIGGIIIJJJIIGHHJIIJFIGGIIIJIIJJIJIJGIGGGJJJJJIIIHHEDFFCEECCDEDDDDDDDCDEEDDDDDC>CDDCCCDD
@31I
CCCAGCATGGCCAGGGAGGAGGGCTGACTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCCCCCGCCATGAGCTCCAGCAGGATGAACCG
+
CCCFFFFFHGFHHGGIIJDHIGIIJJJJJFIIAGGIJJEHFDD@BCCCDDDDDDBDD@ABDDDDDCDCDDDDDDDDDDDDDCCCCDDDCCCDD?CCDDCA@
@31J
GGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJIJJJJJJJIJJHEHHHHHFFFFDDDDDDDDDDDDDDDDEEDDD
@31K
GCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTG
+
CCCFFFFFGGHHGJJJJIJJJJIJJJJJIIIIJIJJJJJIIJIJIJJJJJIJJJIJJJIJGHIIJJH:BCD?CDDEDD>CDDBDDDDDDDDDDDDDDDDDD
@31L
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
CCCFFFFFHGHHHJJIJJJJJJIJJJJJICHJJIHFHIJJJJJGJGEHGJIGHGFHFFFDDECCCDDDDACDDBDDDDDCDCDDDCCDDDDDCDDDDDD@
@31M
GTCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCT
+
@@CFFFFDHHFHHJIIJJJJJJJJJIJJIJJJJJIFHIIJJJIJJJJJJJIJJJJJJJJJJJJJJIJJIJJJJHHHHHFFFFFFFEDDEEDDDDDDDDDDE
@31N
GTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGC
+
???;=@ABFFFFDEEEB<AFFEHFFIIIHEHIEFFDD>FCGFIIFIIIICFI@BF==FDGI=CACDFDEFIDCFFFFCEBDBDDDBBCAB>?@BBBBBBAA
@31O
AAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGT
+
@@@FBDDDHHHHHJFIIJIFGHGGB?DHDHHIIGIJIGGGJIABHI@CEED?>BBC@;A>CDCA;ACDDDD??@BBDDDDDDDDDDDDBBD<BD<BDDDDB
@31P
GTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTG
+
C@CFFFFF<DFHFGJJJJJIGIJJIFIJJJIJJJJJJIJIJJIJIIIIJIJJHHHHHHFFFFFFEEEDEEDDFDDDDDDCDDBBBDDDDDDDDDCDDDDED
@31Q
CAGGGAGCTGGAGTTGCGGCTGCCTCCACTGCCCAGGTAGCCAGGCCCCACTTTGCGGCTCTCGCGGAGGAAGCCCCGCAGGGAGCCGTATTTGGCGTACT
+
CCCFFFFFHHHHHEHEHAHIIIIJJJJJJJJIJJJIIHHIIJJGGGIJJJHHHGHFFDDBDCDDDDDBBDDDDDDDDDDDDDDDDBBB>BDDEDDDD>BDD
@31R
AGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGA
+
CCCFFFFFHHGHHIIJJJJJJJJJIFHIGHIJEGFIGIJJJJJJDHIJFHIJGHIJIIHFHGHFFFCDBDDFDDDDDDDCDDDCDDDDDDEDEDDCDDDD
@31S
TTCCTTGGAAATTTTGGAGCGGTCACCTAGGGAAGGCTTGGATAGAGTGGCCACAGGACCTCCTTCCCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTT
+
@@@DFFDBFFHDFIHFGG>CAAA@ECBGICFGEHE<?FGHIEHCGGEG@HG@HAGIBE=CEEFFF>>CEBC@?@BCCCAAC@ACB<??BA?A?AA<@CCCC
@31T
GCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
@@@DDDDDHDHHHEHGIFI>15:@8>CCCC8AC>@CDDCCCBCCCBBBBBBBBCCCDCCCCCCCCCCCDCCCCBBBBBCCCBCAC@CCC@BCC>ACCCCC
@31U
GGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJBF@HIIJJJIJJJJJJHHHHFFFFFFECEEEEEDEDDDDDDDDDDDDDDDDDDDDDDDDDDD
@31V
CTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
8?@D=DDBFF?BDHIGBEHCDGAFGG>EGGII>GHIIGIIEDDGBFHI@@DHDFFGIGHAGC;;7@DGEAAHEEHHFCFB@DEC@;6A;>@?=BB(::
@31W
TGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGG
+
@@<DB=BD?A:ACG@FFDCGHGB?FH@GB@?11?B?FB9??F;FHI@G@AAFAD;ACHEAA7;???839:@CBCC?@>AC>4>228CBC:>@>:>?2?>>@
@31X
CACCAGGCAGTTCCTGGTGGCCAGGTCTCGGTGCACAAAGTGCTGGGAGGCCAGGTACACCATACCCGAGGCGATCTGACTGGCAATGTGGAGCATTTGGG
+
@@CFFFDDHDFDHGE>FHIJIIEHIGIGHIHDGADHEGGG?FHIIIIJE<BFGEH@=DEDHFEHFHFFDCD>BBDDDCCCCCBDDDDCCDD@ACDDDD:AB
@31Y
AGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHIIJJJJJJJJJIJJIJJJJJJJJJHHHHHHFFFFFDEEEEDDDDEDDDDDDDDDDDDD
@31Z
CATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCC
+
C@CFFFFFHHGGFIIIHIIEGGIIJGICCGIGIIIJJBIIGHIJJCHGIIECEHGIIGI=DGHIHHHHHEFFFDDFFDECFDEEDDC@;@CCEEDC>CACC
@320
CCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
C@CFFFFFHHFHFBHGGHIIHGGIJIIIJJIHGIIIJEGFGIIJJJIGHGFEIGGGIJJJCHFHIJJJJIHIJEIIGH=EEAEHFFFFFEEEEEEDEDD
@321
CGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATCATCGAGACTGCCGGCGAAACCGTC
+
?@@DDFDDFHDDDIGIHHIAFHIHCGEGGIGHGIGHIHIHIGGIIIIIGHIIIGIBHHFFBBC=;
@322
CCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCG
+
@<@DD:=?BF;F:EGAGGIFI@G<F@9C<?22CG<**1?D?<CF<FE<<??(.-8B=887.=/87;@=.).==?3;.77.).(.6;A;5>(-5>ABBB@A;
@323
CTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATG
+
@C@FDFFFFHHHGJGIJJIJIIEIJJJJJJIIIGIJJJJJJJFHIGGIIGIJICHHJJJJIGG@CCHIIIFHFFFDEEEEEDDDEEDCEEDDDEDDDDDDD
@324
CTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTT
+
CCCFFFFFHHHHHJIJJJJIJJGIJJIJIJIJJJBFFHIJBHGGIFGHGIIJJIJHIJJJJIIJJIJIIJJIIJJHHHHHGFFFFFEEECEECDCECDDDD
@325
CTCGAATTTGTGGACTTTGATCATTAGAATGAGATCCCTCTTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJEIIIIJHHHHHHGDFFDDEDDCDDDDDDDDDDDCDDDEDDDDDDDDDDDDDD
@326
CGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATAT
+
@@CFFFFFDHHADHIIIIIICHEGGIIIIGIIDBGDHHGCGGGFGDI?FH@CHIIEHHHFFFFCECCCAECACCCCCCCCBACCCC>ACCC:@CB@CCACD
@327
ATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCCCTGCCTCTTGACTGGCTTCAGGCAAGGAGGAGGCATCCTCAGTCCCCATGATAAGGAGATT
+
???DBDFD?DD?FDHHIBEFGGHCHEGHIIIICGIGHGGFDCDDBFDFGHCHGHIGIIGGAGGHDHEHE<;?D=A;@?AC@CC@A@?CCCCCACCCCBA?C
@328
TATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCC
+
@@@FFFFFDDAFFBGGIJIIGEFGHCFHGHEHHIJIGI?FGGFGGIIIIGGIIJJEEHFFFFDEDDCCCCDDDDDD>CC?ACCCDDC@CEDDDC@CACCDD
@329
GCCAGGGGCCCTAGAGGATCAAGTTTCAAAGGGGTTGCAGGAGACAGGCCCTGAGACCCATTCATCAGCTGTGTGTTCTGAATCTGCATCTCCTCAGCCTC
+
@?@ADD>DADFHFH@GHIIII9E:C<?FFIGIEDF<FGH<?F;BB=.5;@D==CEHEEEEED>6>@@CC@CC;;=5:>@CCCCC:;(:>>>CCCC:(4?CC
@32A
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
C@CFFFFFHGHHHEGGIIIIJJJJJIJIIJJJJJJGHIIJIIIHGIIGIIIJJIJJIIIIJJIJGIJJJIIII=BDFFFECEEDECDDEEDDCDCDDBDC@
@32B
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
@@@DDDDBF<FDB;FEGGDEE8C<EC?FGFIFF?D?BFEFIIIIIFIIIFIEF@C;@7CEE9A59<>BBBBABB6/<<BBBBBBAB@4:AB?B9@<?A@>@
@32C
TAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCC
+
CCCFFFFFHHHGHJJHJJJIJJJIJIHIIJJIIJJIJJJJIIHJJJJJJJJJJJJJJHJIHIJJHHHHHHGFFFFFFFFEDEEEDDDDDDEEEDCDDDD
@32D
CTGCTTCCTTTTTCTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCC
+
?<1==BAADD?DH>?FFHI?IG:A?C>32AFFHG>8EE*CF<*1B*:9?GGAFF?D38*.=88C@@@3=87=4@;7.5?/;4;AACCC>>(-5;CC:@>AA
@32E
CTCCGCGGCTGCACTTGCTCTCCGGGGCCCCAGGGCGCCGGCCCAGCATGGGCAGTTGCTCATTGTTGGAGATAAGGTCGCGCTGGTCATCCATGACTGGC
+
@@<DDDFFHHHHGJJJGHEGHGIIIJJJGIJJJIHGEAA>@BDDDBDDDDBDDCDCDCDCDDDEDEDDDCDCDCDDD>C>BB@@BDACCDDDDCA>@CDDB
@32F
GGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGT
+
BB@DDFFFHHHHHJCGHJJJJJJJJIIJJJIJJJJJGHGIJJJJJJJFHJJJJJJJIJJJJHHHHHHHFFFFFFEEEEEEEDEEDDDDDDDDDDDDDDDD
@32G
CCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATAC
+
=;@DDDADFHB;+<CDEHGGBFCHBFFBF<BFHID@GGD<FH@@GH3?BF>ACFABFC=@GAH@C=DAEFHHHEE@;?CCC@AC(;>;>C>>>BB;=BDD
@32H
GGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGC
+
=@8ABDDDFHFBCFHFHGEHHGIIGHIDE<FBB):C?CDHHGI8?FH@@GEC@@D@EH??B;BEA>ACCBCCCC@@CAA>A@CCBC(,>>::>@C@A>CC>
@32I
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJJHJJJJJJJJFHIJJHIJIJJJJJJIIJJIJJJJJJJJJJJJJEEEHFGFFFDEEDDACCDDDDDEDEDDDDDDDDDDDDD
@32J
CTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCC
+
@<;?4A8@8C?CF?<EBGFFCECHC>C@C==FFGB=FFFFA.7@CAEEF7=AC>B@D?(;(3;>?BA?A>@>(>::>::>+4:AADB:@AB5<?7@>@B9
@32K
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJGIIIJJJJJJJJIJJJJJJJJIJJJJJIHIJJGHIHHHHHHFFFFDEFEEEEEEDDD
@32L
CTGTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTC
+
:?+==BBBF??FBHG@FFDDHCEHG;E?DFHIG<:CDGHAGBCG>FHGGB>GHGI:DBFFHHDG>;CHAGD:@==EG@GGDDE?AC>3?CEBCDECCCCCC
@32M
GGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCA
+
CC@FFFFFHGHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJIGIJJIJJHHFFFEEEEDCDDBDDDDDDDDDDDEEDDDDDDDDDDDDDDD
@32N
GCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCAC
+
@;@DADDDFDFDDGGIICHBEC>C;EFBAHHIIGGIFHGCBFE?BFE78B)?38?DAHE<@=@@C;EGGFHFEEHHEEB(',58??5;@?BC>ACC@:>>
@32O
CTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTC
+
@@@BDBADAHFBDGHEFH@H?EGEEEGG?FEAGDEH<AGGGIGBFEEGII@;?:BBCBEEECBBB?<ABB=>@BC@>AB<?BCCDAACBACBB999<@B?B
@32P
GCGTGGTTGGCCTTTACTTGAGACTGATTTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCCTTTAGC
+
=@=B=@ABFHDHHGIIBHIC@DC@HCHHGHIIIGIF@BBBEBDHHGI@=7FCAEADHGIHEHEFBEFBDADCABCCCABACC3:A?999<<?>BBBDDD>C
@32Q
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CC<DDFFFGHHHGJJJJJJJJJJGIGIJJJJJJJIGIGIIJEIIGIIJJIJJJJECGIJJJIIIJHIHGHGGFFFFDFFDDD9?BD=CCDDCDDDDDDDDD
@32R
AGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGG
+
@CCFFFFFHHHHHJJJJJJJJIJGGJJJDGIJJ?FDGHIJJJJJJJGIGIDGHFHFECEFFFFFFEEEEEEDDDDDDDDCCCDDDDDBDDDDDDDEDDBBD
@32S
CCCTGTACTTCTATTTGGAAGCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIIIJJJIJJJJJJJJJIHHHHFHHFFFFFFEEEDEEDDDDD
@32T
CTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCT
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJIIIIGIJJIJJHIJJIJJJJJJJIJJHHHHHFFFFFFEDEEEDDEDC
@32U
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCCG
+
?=1==0=<D3<2ACG?AGFIFA?HHFG@B1C*?9C:?1?190B3BB9?@DD<BD*89BC>;5C37@4=A(;A>/>39>A3>AB?8@>:?>5:?>
@32V
ATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCT
+
CCCFFFFFHGHHGJJJJIHHEHIJJJJGIJHIJJCHIIIJHIIIHIJJJJIIIGIJJGGGEHIJGHHHFFFFFFEECCDBDDDD@CDDCDDDDCCDDDDDD
@32W
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@?@FFFFFFFDFHJFEEHJJEGIGIHIIGHGGGIGIIIGIIJJAAHIDFHAEGII@=CEHE?CDBB;ACEA@CBBB?;@>>@;@5?>>CCC>AAD??<8:A
@32X
TTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGC
+
?@:BDD;DHHDFHIIIIIFGGIIIIIEHIIFIEGFHCBFFFHGIFGG>B<FGGGHGFFHE@FAGHICGEEECHEHEH@EFBA<<?CDCDDECCC:ACDD>A
@32Y
GTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTG
+
@=?DDFFFDFHFFIGGGHJCGGIIJBEHIIJJJJJIIJJJEIEFGGIJGIFGHFHHHGFFFFFFCECEC>@CDCCCDDC@CDDDDBDCDCDDDC>@CDCDC
@32Z
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
@C@FFFFFHHHHHJJJIIIJJJJJJJIJIJHIJJJJJJJJJIJJIJJJJJJJIJJJJJJFHGIIIIJHHHHHFFFFCEED@CDD;?BDDDDDDDD<ACDDC
@330
GTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGT
+
B@@FFFFFHHHHHJJJHGIHHHIJJJJJJHIGJJJJJJJJJJJJJJJJJJJFIIJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFFDDDDDDDDDDDDD>
@331
CTACTTCTGATGCAATGAAATAAACTATTTGGCGGGTCGGGAGAAGGAAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAG
+
?<<;1+=BD,ACFI<4C44::AA+A,4:4A++2))(''-''-',(6(.(-(-5@>(5(((,,,(,5>@>(>@B(+5<((+(((:3(44>3:+(((+4
@332
CTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCC
+
?@@?BDDDHDFADHHIIGGEGHIF>HIHE9C<F99?CBCFFHEBHH0@0?0(.=F@8/5@3).7===?;=B).).;766>C;C;AA=5>><,5:@5:>CCC
@333
TCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
B@1ADFFFHHHHHJJJJJJJJJJJJJJJJEGIHJJJJIJJJJJJJJJJJJIJJJJJHHHFFFDCEDEEDCCDDDD:ACDDDEEFDDDDDDDDDDDDDDDDD
@334
CCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGGCTTCC
+
@@@DDDDBHF4ACFHCBEEFBHBBDD>BFHIIIIGGAFDEGHH<@F>AGI<?CF>8;AB=7@7?C?CCC<8?:AC>C>A:38@C@A@@@@A>91?&22<<@
@335
CTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACT
+
CCCFFFFFHHGHHJJJJJJJJJIJJJJJJJGJJJJJJJJJJJJJIJJIJIFHIJJIJJJJJIJJJDHIHGHGHHFEEDFCCEEEEEDDDCDEDEDDDDD
@336
TGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
=:<DDD:A3ADB8FGGGHBH9AEEGGE)?6@@D4?9B=6@@7)=D@;8@FFCGGEH::95?)66;6>AC35;5;(55:A5;;;,>@@:C:??8@CBCC?<
@337
CTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTT
+
@@@DDFFFAHDGFIJJIIGHIJJJHHIIJIJJJIJIHCHGHJDFIIJIIJGIEIJJGHIIIIGHHHHFFFDBEEDDDDDDBDDBDCDDDDCDBBBDDDDCD
@338
GGCTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTAT
+
=?14=BB?2ADFHIII><FDIGIIGGAHIGIBEEGGIHGDHEDHCHEG@=G@DDHEFHHHDDDEEC?CCC@DCCCC>A>3@>C:@?839><8?C????CD
@339
TTCCTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGC
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJIIIJJJJJJJJJIJJJJJJIJIJJHHHFFFEEEDCEDDD;?@DDDDDDDDDDDD
@33A
GTTGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTT
+
=?+ABDEDFFHGFIGHIIIEEHIBEBFIIGIGIIIIIIIIFIEGIIIIIIEGHGEGHGCFEIIIIHGFGHGIBHGCG>C?CHHFFEBBCBBACCCBAA@DC
@33B
ATCTCATTACACTGTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGG
+
=@1=BBDFFHDFHIEFHIJJDHHJJGIIBHHGHGCGGGI?FEGGIGDDFHCGIHGGGHICHIHGIIECGBFEHIGHIJHHHHHFDDCCCDCCDDDDDDDCB
@33C
CACAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGAT
+
:?14ADDFHGHHHJJJIJJJIJI?FHIGIGHIJHJGIIIIIJJIIGJIIIJIIHHFFEDDCECEEEEEDDDDDDCDDFEDDDADDACCBDDDDDDBCDDCA
@33D
GGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTT
+
@@1DDDABFFDHHIHIGDGGIIHIJJIIIJIJEIIIIIJIIIGIIJJGHI=@FHGJGEEEHFFFFDDDFEEEECEDDDDDDEDDDDECDCDDDDDDDDBCC
@33E
CGCAGGGAGCCGTATTTGGCGTACTCCACGATGAGGAGGAGCGGGCCATCCTGGCTGCAGGCCCCATACAATTTGATGACATGTGGGTGGTTGACCTGCTT
+
@?<AD<<DD:F<<CFHI>?FCEABCGDDGGG;1BB??CGHCEIIFCABCC?CC>2<?<CAB;BBB<9A9A@CCCC>C:>A@@44:>><BB>@BC@>@<<C@
@33F
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
@@<DDDEBCCDHDHGEGHGGFGGCDHFB?BFHBBFHHGDFEHGC@D>HF>@FH7@CDDGHHEEEEC7?D@D?CDBD@A>;@C@AC:CC;A:ACDD>@C<AC
@33G
CCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAA
+
@@@FDEFFFHGHHJJJGIJJJIJJJJIJJFJJJJJIJJIGIJIGGIIJJHJJJJIJJGGG@FGHGHHJ@CEBFHGEGIJIIIGGGAEEEHADFEDDECCD
@33H
AAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTT
+
BC@FFFFFFHHHHJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJHFFFFEEDEEDDEDDDDDDDDDDDDDDDDDDDDDDD:AB>CCDDDDEDDDDDDD
@33I
GGTGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTG
+
?@;BDFFFGHFFDHIJJIIEGIGEHEIDFHIGIDHEGGGG<FHIJJB@FGIGEHIIGGCD;DGEEAEEB?==?CCE>@CDDDDDEEEEEDDCD?AA??@C>
@33J
CCTTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATTACTGTAAATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGC
+
??;AB:DD>AABD++2C4<ABAAF++AFF4F4<*:**:??C19?D@DD*0*??09B*9?989D)///8B==@:C;8=AC7@5;=(;;).;3(.;;AAA;A:
@33K
GGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTC
+
BC1BDDFFHHHHHIJJJJJJIJJJIJIJJIJJJJJJIJIJJHIJIIEGIIJJJHIJDIJHIIGIJHIJJJIJHHHHHFFFFDD?CD:@CDDCDCDDDCDDC
@33L
GCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
CCCFFDDFBHFDHI>EGHIIIGIIHDHHIHIICDGGGHDBFCGHGI;BEGHEFFFHF?B;ACBDBCDDDCCDDDDDCDD>@CDDDDDDCDDDDDDCCCCCD
@33M
CCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGT
+
BC@FDFFFHHHHHIJJJIJIIJJJJHIJJJJJJJJJJHIIIJJJIIGIJGHGHIIFHEHEHFFDDFEEDD@CCA@CDDDCDDCCDDCDBDCDDDDCDDCCC
@33N
GTGGGATTGTAACAACCAGAAATATTCCAACTATAATAGTAAGTATGAAACTTGTTTCTGGTATCCAAAAATCATCTTTCGGTGGAGCGTCAGTGGGCTTT
+
CBCFFFFFHHHHHJJJJJJJJJJJHIIJIJJJIJIIHIJFHJJIJJJJJJIJJJIIJHIJJIJIJIIIJJIGGHGGGIJGHHCDEDCCDDDDDDDDDBDDD
@33O
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
B@BDFFFFHHHHGIHGIGHIFHHGGJIIIIJIIJIIJIGIEHIJIJIJIHIIJJGHGIGGEHIIJIJIHHHFDD59>ACCD:A>?CDADEECDDD@CCB
@33P
GTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTT
+
@@@F?DDDHDFFHGIJIJJFBGFBAFHIIJIIIGGIIJJJBHIJIGGB?BGG2CFDHHAAEBDDDBCCCC@CCBCA3AC:=;?@ABDDCDCCCC@>@3?BD
@33Q
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
C@BFFFDFGHHHHJJJIGIIICGGHJJJIJJJGGHIGJGJIJJJIJAGIIIIIJIJJJJJJJIJJJJJGIHHGFFAECDEEEDDDDDDDDDD9CDDCDBD2
@33R
CTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCT
+
CCCFFFFFHHHHHJJIJJJJJJJIJJJJJJJJJJJIHIJJGIJIIHHFFFFDDDDDEDDDDDDDDDDDDDDDDDDDDD<ACDEEEEEEDDDDDCDDDDDDD
@33S
GTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
@CCDFDDDDHDHDIEEEGHIIG?HHIIIIIIIIIEBEHIGGIGIICHIIGGA8BCHCCGACEGGGIHHACEFFFFEFECEED=@CDBB<;?8?B5?ACCD@
@33T
GTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGT
+
@@CFBDFDFDFDFGBHIJJIJJJGIBHBGFGIIGIIFFFHGHHFDFAC@EECDDCDDCDD:>AACCCD??>BBBD>BBD9BD28@AC@CCBDDBBDD@BBB
@33U
GATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAAT
+
CCCFFFFFHHHHHJGGGJJIJJJJIJJHHJJJJHGGIIGBHIJIJJGHJHGJJIGIJJJIHGE?BBDDEEEDEECDD@CDDCDDDDDDDDDEDEEDDDDDD
@33V
CCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTGTTC
+
???DDDBDBDBDBEEADEA3?**::CEE<<DDE?:99?DDE@@DEADBD9BCED:CCEE8@37ADC;7?A>ADDD@@AA6;AAAAAAA5;AA>A??A75<>
@33W
ACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGATTGCCATATGC
+
@@<DBDDDFDADC+:CFF:ACF@HE>@FHIIBFFA@D?BFG3?B?FD9B?BC=FFA>C;5;))7A==@>;:3(.3.;>>;;>=?/(,9(,((:@AAB>>
@33X
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHHHHHJJIJIJJJJJJJJJJJJIJJJJJJJJJJJJJJDFHIJJBEDEEEEDDDDDDDDDDDDDDDDDDEEDDDDDDDDDDDDEDDDDD@C
@33Y
GCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGC
+
CCCFFFFFHHHHHJIJJGHIIJJJJJJJIJJJJJHGGGIJIIJJJIIIJJIJIJJJIGHHHHFFFFD9>B@CDDDDDDDDDDDDDCCDDDCCCCBDDDDDD
@33Z
TCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTC
+
@=?DDFFDGDHGHIEFHHGHIIIIIECHGIIGIIC>GGIGG@FGHGEHIHIIIIIFGIGIIAGGIHHHEE@CF?BC;?CCCACCCCBCCCCCCCCBBBCC4
@340
GTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAAC
+
CCCFFFFFFHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJGIJGIJJJJJIIIIJJJHHEFFCEEEEDDD>ACBDDDDDDDDDDACDD
@341
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CCCFFFFFHDFDFGHIJJEHHHJHIJGJJJIGJJIIIGIIJIJJIJIFHIIIGGHIIHHIJIJJ;BFD9CECDCCCDDD@BDDDDDDCDBDDDDDCDDDDD
@342
TGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCAT
+
@@CDDDFDFDHHHJBGIJEHHIIGHBHIFGIIJJIJI@FHIJJGIIJFAHHHEFEFFEECDBDDDDDCCCCBCCCAADDDDCCCCDEEDC@BBBBCDDDDD
@343
ATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGG
+
?1=1?4=,+=DFHBG9F>HFCFFC9EA18)1C;:CD?F9D49?BDABBGHB;DB<1=44,3'6(5(;C>;@CC:5:5(9,,(50599(+(3+9+((4@@DC
@344
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
CCCFFFFFHHHHHJJJCGIJIIJJAFHIHIJJJJJFHIIJHIIJJJJJJJJJJJJJJ;BHHHHHFFFFBCEEEEEDDDDDDDDDDEDEEEDDDDDDDDDE
@345
GTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGG
+
=:=DDD?DAB3DDFGIIFE<G<?:FGA@D86/9=C88B8=FF;;B?E?3??D?C@9,;B1'>B@:ADA>4::@:A:A>:832<2(3++3<?B<@B:2(0
@346
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@@@DFFDFHF<FHBGGIJJIFHIGGGGHBIIBGGDBFCHIG@FI?BFEHJIEEHCEHIIIGHA>EBE:?DC@@A=A-;>CC5@CDC>C><>C5::@?9AC
@347
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFFDEDFHHHHIJJJDEHAEEAHIIGHGGIGIGIIJIIGHIIEFIDEHEEGGFCFHIIGIIJJJGGFFFFFFFDEEEAE@B;;=CCCCAA:@>AC@CCB
@348
GTACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGG
+
CCCFFFFFHHHHHJJJJJJJJJIJJJIJJJJJJJDDDDDDDDDDCCDEDDEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDD
@349
GCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCT
+
@@@DFFFDFHHHHIDHHIIIEGGDEH@FIIIIIGGEDHBHGIGIEGIIIHIIIIECFGGFHGGHHBEEEDDFB@>C>@CDBDDDDDCCDDEEDEDDDDCDD
@34A
GCAGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTG
+
@C@DFDEFFHHHHIIG@GGHBHGHGIJJIEGHIIJJJGJIJIJJJJJIJIIIEIJIJCGHIIHFH9=>9@CCD>@?=?BBCDCDDDDDDDDCDDBDDBDCD
@34B
CTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGG
+
@BCFDDDDHHFH<CEFHIJIFGGHIHGFHIJJGGHIEHGIIGIJJ;BHGHGIIJGG;CGHHGHHDBCEECCC@CCDDED@CCDACDDEDDCDEDDCDCB>B
@34C
CCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATT
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJIJJHHJJJJJJJJJJJJJJJJJJJIJJIJIJJJJJJJJJJJJJJIJJIJJIHHHHHHBDFFFFFFEE
@34D
TCATGATTTCATCTGGGGTTTTCATAAACCTGAACAAAAGCCTTTGTCCTGGCTCCTTCCTGATAATGTTTAGTTTGTAGTAGTGGCGCAGGGCTCTGGAC
+
CCCFFFFFGHGHHIJJGJIJIJJIIJJIJJJJJJJJJJJIIGHGJGJIIJJJJJGIJJJJIJIIGGGEHHJGHEHFHHBEDDECFCDBDDDDDDDDDDDDD
@34E
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHHHHHJJJJHIJJJJJJJJJJJJJJIIJIJJJJJJJJJIJJIIJJIJJJJGHHHHFFFABDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@34F
GGGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGC
+
@@@ABADDFAFHFGBCGE@DFHGIIFHIGIIGIGEDDGGGIIICEHDAHGGEDHIA@>EA?EBBD>CCEECEACCAA??A<AA@ADCCCCCCCCCC>:AB?
@34G
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHGHHIJJJJJJIJJIJJJJJJJJJJIJIJJIJJJJIJJIJJJJIHGHHHFFDDDDDDDDDDDDDDDDDDDDDDDCDDDDCBDDDDDDDDDDD
@34H
TCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJIGJJJJJJJFHIJJJJJJJJJJJIJJJHHHHFFFFFFFEDCEDDDDACDDDED
@34I
CTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGC
+
?<<;D?A8=<DA<FGI@AFAG>+AH+A<?EFD660BFDCI@B''6;C@>8@=E;=7=A;=455;1>>;@@BA;5:;@>?5>B@;>;;(+(+>((3<BB>??
@34J
CAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTG
+
BCCDFFDFHHGGHJJJJIHHIJJJJJJJJJJIJGEIGHIJJIJJFIJJHHIJJIGIGIJIIIJJJJJJJJJJJIGHHH7=ACECDDDDEEDDDEEDDCCAC
@34K
CCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGAT
+
<<<?DD?;DAD?4CCFID<ICF?9FH@F<A@9BEFHDDH@DAGBBDDF?D?DGIA@BF2CC@=@F:CE>;@E?AE8=A?B?;,,;A5@CB=?BCCCA?<BB
@34L
GTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTC
+
C@CFFFFFHHHGHIGICHGGHIJGJEHIIIIIIJIJJIJIJJJJFJJCCEHJIIJIIHJIJJIJIJIIHHHFFF?DDEEEEEDDDDDDDDDDDDDDDDDD
@34M
GAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJIJJIJJJJJJJHHHHHHFFF=BDD@DDDEDDDDDDDDDDDDDD
@34N
CCCCACACTGCTTAAAGAAGTCTGCCAGATCATCTAGAGTCACACTGTCATTTAATCCTTGTACATAAATTGCACTGTTGTCAGAGTCTTCATCTGGATCT
+
@@CFDDDDHFBHGHIIFEHGHGHHIIGIHHIIIIGIGIIHHHGGIIIIIIHIIGGHHHGGIFHCHIGHDEHGIIEHIIGHHCAA?ACDFFDDECCCEECCD
@34O
CTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTC
+
CC@FFFFAFHDFDHGIICHIIIHHEGIIIIIIIGFFEGHIGIIIGIGIIIIIIIIIGIIEHGIGHFEHFFFFFFFDDCDBBBDDDDDDDDDDDDDDDDDD
@34P
GAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCC
+
CCCFFFFFHHHHHIIGIJIIJJIIIJIJJJIJIJJJIJIJIJIJJJJJIIJJIGIIFGHHFFFFFDEEEEECCDDDDDDDDCDCBDDDDDDDDDDDDDDDD
@34Q
AGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATG
+
?<;DABDD?+C?2:2:A3C1AAE<FC8F8?ED):?89*9B21<3)8==@@AE;;=C;=CCDD<D?A@6>>>;>>A:-5>A>>5>?3>35;>>>14(4(>:>
@34R
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCT
+
@@@FFDFFHHHFHJHHI@HHIJIJIJIJJJJJEHJIJJJJFIJJJJIJIJJJJJIIJIGIGIIJJJJHHFDBBDDDDDCC>AC@DDEEDDDDACCDBDDDD
@34S
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
@CCFFFDEHHFFDIJEHIIIIGJIIGJJIIJJJJJGIGIJJJJJJJJEEHIIJJJFGFFGHDGGHGEHHFHHFFFDFEEEDEEDCDBBDD8AD58>BDD5@
@34T
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
<@<DDDDDFFFF8EEGGGIIGHHBDGD?):C<D?F?DG@HC21C;FC@CCCH9)7:8?<(6>C;5>;>;>3',8?BCAC>CC?C:@844>ACC(2>ACAC@
@34U
TCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCT
+
CCCFFFFFHHHHHJJJJJHIJIJJJJJJJJJJJJJJJIJJJJJIJJIJJJJJJJJIJJJJJJIJHGGFEFEEEEEEDDCDDDDDDEEEDCDDDDDEEEEDD
@34V
GCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCC
+
@@@FBDDFHFHHHGIJIGGIJJGJGGIIIIJIJJIJJJFIIGGHIADEBCEEDDDDDDDDBDC:@B>CDC@CDECDCEDDDCCDDDD@BDDDDDCCCCDD
@34W
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
BCCFDDDFHHHHHJJHHIJJJJJJJJJJJJIIJJJIJJJJIJJJJJJJJJJJJJJJJJJIIJJJJJJHHHHHHFFDDEEDDDDDDEDDDDCDDDDDDDDDE
@34X
CCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGT
+
@@@DDDDDBFDHHIGHBGIIIBEHIHHHIIIIIGIIIGGHEHIIGCFEA7@C@DDACEHHCFFFF@CACC.;CCCCAAACCDDDCACCBDCBB@ACDCDDD
@34Y
CTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTG
+
CCCFFFFFHHHHHJJJJJJJJJHIJJJIGIJIIIJFHIJJJJIIIJJJJIJJJJJJJIJJJJJJJHHGHFF<BDEDCDDDCDCDDCDDDDDDDDDDDDDDD
@34Z
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCT
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJJJIJJJJJHIJJJJJJJJJJJIJJJIJJJHIJJJJHHHHFFFFFFEEEDDDBBDDDDDDDCDDDDDDDDD
@350
CCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTG
+
@CCFFFFFHHFHHJJIIJJJJJHIJIJIIHIJJGJJJJJJJJJHIIIJJIJIDGHIJJIGBHGGIJJGHGIJJHGIIJJJJJJHHHHHEFFFFFFEEEEEE
@351
AGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTG
+
CCCFFFFFHHHHHIJJJJIJJJJJJJJFHIJJJJJJJIJJHGIJJJJJJJIIJJIIIFHGHHGIDGIJJIHHHHHHH;@DDCDEDDDBDD>BDDEDCDDDD
@352
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJIGHIJJJIIIIJJJHGHJJIJJJIJIJIHHHFFDDDEEEDDDDCCDDDDDDDDDDCDDDDDDCDDDDDDDDDDDDD
@353
TTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGT
+
CCCFFFFFHHHGHJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJIIHHHHHHFFFFFFFDDDDDEEEDDDD
@354
CCACACTGCTTAAAGAAGTCTGCCAGATCATCTAGAGTCACACTGTCATTTAATCCTTGTACATAAATTGCACTGTTGTCAGAGTCTTCATCTGGATCTAC
+
@@@DDDDDHDHH?E@BGBCHHBHEGCHIIIIIIIIG@CGHGIIGGGHHEHFHGIEHIGGDFHIIAE@FIEHIIGIC@E@CHHEFEHACDEEEEE>CCCCCC
@355
GCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATGTTGAACAGATTCCTCCATCATCATAATGGCTTG
+
@?@DDD>DF:AC?FFD:C::AC@FGCBFFBA??B@99CFBG@>DDBDGEGABB9??B*>8BF=FA@CF==)7@7==ECC;C@>BBDC;>A@ACA>;;;=?2
@356
CGTCCTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCTCTCC
+
?@=BD?BDBB:ADFDDFIAFD:<<?FDCBFAC:CFCG@FFFF'<CFI7====CE@AAE>E7;7.;?>BBA@BC@ABA;?;@@;AB::ABBB@?BB?B@BBB
@357
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGT
+
@@@DD;DDDH<DFFIHIGGBGEHIIE@FBHHEGDDHHEIGIIGGIIGDCHIGHG<GGGBEHHDBBB@BC>@@C;>AC@@CCCBBB9>A@@@CCCCCCCCCD
@358
GTCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJHHJIIJJJJJJJJJJJJJIHHIJJJJIIJJJJJJJIJJJJHHHHFHHFFEFFFFDDEEDDDDDDDDDDD
@359
GCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCC
+
CCCFFFFFHHHHHJJCGHFHHJIGIJIJJJIJJGIJDHIJIIJJJIJJHHHHFFFFFEEEEDEEDDDDDDDDDDBDDDDDDDDCDDDDED@ACDDEEEEDD
@35A
CCGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTA
+
???B=AADB?;;2CCAE<<A+2C?EEE3:DD<?0?DD?BD<?20B?B@CB768C;@<AD;6;;;?AA>;55(5;;78?>(:5;;;:(++(2(288<8+4
@35B
GGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCT
+
@@@DDDDBFDFBDGGHIEHIFHECHGIIIBBBDDHGBGCHGGGGIIIIGI>DEAEDEC>>CCCCCABCCCCCCC5;AA>CDADDC<@BBBC9<@5?@DD>>
@35C
CATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJGIIJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJIJJJJJJIIJJJHHHHHHHFFFFFFEECDDDDDDDDDDDDD
@35D
TTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTT
+
@CCFDFFFHHHHHJJJJJJJJJJJIIJJJJJJJJJJJJIIIJJIJJIJJJJJJJJIIIIJJJJJIJJJJJJIJGIJGIIIHHHHHHGHFFFFFFFEEEEEE
@35E
GTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGTTTGCTTTTCCGCTCGCCCCAGCGCC
+
CCCFFFFFHHHFHIJJJJJJJJJJJJJJJJIHIJJJJJIJIIJJJJJJJJIJJIIIHHHGFDFDDEECEEEEDDDBBBDDDDDDCDDBDDDBDDDDDBBDD
@35F
GCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGG
+
CCCFFFFFHHHHHJJJIJJHIJJJIJJJJJJIJJJJJJJJJIJJJJJJIJJJJIIIJJJHHHHHHFFFFFEEDDDDDDDCDDDDDDDDDDDDDDDDDDDDD
@35G
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@@@FFDFFHHGHHJJIIIGIIJJJIIGFCEIJJIIJIJJIIIGGHIGGGDEGBFHE=FHGEEHGGEDHFHGFFFFBDFFDDD/;?B;CDDEAC>CBBDD>B
@35H
GGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGG
+
CC@FFFFFGHHHGIIIJJIIJJIJJJJJJIJJJJFHIJIIICCGIIJJJIJJJJ@DH=BB=CEEEEDDDDDDDDDDDDCDCCB9@DDACBDDD
@35I
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCC
+
CCCFFFFFHHHHHJJJIJJJGHJJJJJJJJJJJJJJJ@GIJHHIJJJJHIJJGJHHHHFFFFFDEEEEDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDD
@35J
CAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTGGCTGGGGTATGGCATATATCCA
+
@@@DDD?DFBFFBAACFDFHBE81?:CBFFGFC:6@FEFFFDEAA7CDADEECE;A@;@BDBAA@BBCBBBBB@>ABB@58?9)5AB@@AABABADDB
@35K
CTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGG
+
CCCFFDDDDHHDDF>DFBHGIIGAFEGGEIGIIGIFGIGBB@FH9DC6=FB@DAGAFGHGH=)=AHEHDDFFDBBCBBCBB?B?:BC<B>CCCAC>ABBBC
@35L
GGCAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJHIIJJBFFHJJJJJIJJJJJIHHHHFFFFFFEEEEEEEDEDDDDDDDDDDDDDDDDDDDDDDDDDDDEDD
@35M
ATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCG
+
CCCFFFFFHHHHHJJJJJJJJFHJJJJJJJJJJJJJJJJJJJJJJJJHHIGIJJJGHJJJJHHHHHFFFFDDDDEDDDDDDDDDDDDDDCDDDEDDDCDD
@35N
CTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTT
+
CCCFFFFFHHHHHJJJAACIHIJJJIIJHIHGHHIJJJGJJJJJJJJGIGHJJJJHHHHHHHFFFFFFFECEDDDDDDCDDCDDDDDDDDDDECDDDDDDD
@35O
CTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGCGAGGTTGTGAAGAGGGCTGGGGAGAAGGT
+
:?;D4B:DAD<:011AFFBF<<?AFB?111C110:090?FGBB9D@FIF@FI)8.=F>@8C7.=D)=DFE>),'99,;@',,,:(5<B'8@9<9@B5?3<>
@35P
CTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTT
+
@@?DDBFFDHHDACCEEIIDDFGHIIIIIGBBDADEGGHDHBBHGHIBFBDBGHGGHBDDGHDB4/B..=@7@>8=@C=@CCCHEHEEEEBCDFFFCCCEE
@35Q
CGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGA
+
<@@DDDDDFDH<F,<AA<FCHEHH<<ECADFGFGEHICGHH?@FHIDCFCFEGHBGIIEGD<BFFFFG77CGAGG<HGFCAHEECCEEC>>@CCCCDDE<
@35R
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGT
+
@@?DDFFDH?FHFEEHIIIGIGCGIHGHHHIIGHGEHDGH@;FCFDFGHIEGEHDDHI@EEGCHHHEFFF@?@@>CCBDDDD<CCCDCDCC@CCCCC:@@>
@35S
TGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGT
+
@@@ADBDDFHHAF?AFEB?FGIEIEEH;EG9C@FEHEG>FA=BGFHG?F<?<BBDHGGGGGGGB7C6@GEC?E>ADEE@?;@A;@A;AA@>@>@CC>>CCC
@35T
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTG
+
@@CFFDFFHBFHHIG@GGGIIIGGIIGGIIIGGIHIHIIEHIGIGIICHGIIIGICHGGEHEHHE=ABDDCDDDCD@;BDC@C@CCDCCDDDDDD@BDDDD
@35U
CACAGGACCTCCTTCCCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTTCCAGGGGCACAATGGGGACCAGTTGAGCAACTGGTGGTGGAGGCTGAGGCG
+
=@;DDAD?CDAFHIIIBGB@@E:F@BCD?90:BBB?B>FBBDGHIGHGCH3)=7)4:/9;C>CCCA@18;<@>A>@A@:<BC?9+329?B?B222?BBB?B
@35V
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
@CCFFFFFGHHFDHFGIJIJJJJJJJIJJJJIIIJJGGHIJIIJJIJIIJIJJJIIIEHGIIJJ/=BB9@CEDDC;@AD<@B@BBBDCCBD@CCDDDDDDD
@35W
CTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTG
+
CCCFFFFFHHHHHIJJIJJHIJIIJJIJIIJIIJJJJJJIIJJBGIJGIIJ7EGIGHIJGIH;CHGFBDFFFEDDEDDDDDDDD?BDDDDDDDDD@CDDDD
@35X
TCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGT
+
@@CFDFFDFFHFHEHE,AECHIHDEHGIJD<EHGIIJGGGIJJJ9FFGGGGH<BFIII:*?DFIGHGIGHIIIJ@CCGHAAGECHH@>;?@BDFCC>@CE;
@35Y
CGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGC
+
@?:=DDDDFACACA<:88)<?<AAA?F?9??DG??9*?FA6??BFF<=;==7=778D==@67A>>B7?..?;6;6.(,',38AB>55(5:5493220+59
@35Z
CAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTC
+
CC@FFFFFHHHGHEIGIIHJDGHIIJJJIJJDHGIIIAFIIGIIIEHIIJJJJJJIJHHHHHFF@DFDDEEDCCCCDDDD;=B>CDDDDDDDDBDDDDDCC
@360
CTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATT
+
CCCFFFFFHGGGHIIGIJIIJJHJJJJJJJIIIIJJJGHHIIJHGJIJJJJJJJJJJJJJBFHJHIGHHHHHHGFFFFFFFCEEE>ACCDDBDDDDDCDFE
@361
GTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGG
+
CCCFFFFFHHHHHJJJJJJHGIJJJHIJJIIJJJJJIJJJJIIGIJIJJIJJJJIGAEEHHHFFFDECEEEDDDDDDDDDDDDEDEDDDDCCCDDDDDDDB
@362
ATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTG
+
@B@DDFFFHHHHHJIJIIJJIJJJJIJJIJJJJIIJJJJJJFHIFGFHHIJJJJJIIIDHIJJJJIJJ@DHHAEBFFFEEEEDDDDDDDDB@<BBDDD09@
@363
GGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAA
+
@@?DDFFDHFHHHIIJGAHHIIIGJIIJHJJJJJIIFGIII?FGIIJEIJFIJIIHIIIJIGJIEIIEBEGGIHIJIJIDHIGGGCEHH>CDFFFFEEEC
@364
CGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGC
+
@CCDFFFFHHHHHJJJFHIJJJJJJJJJJIIJGIIIIIIJJJDDGGGHIJJJIIIJGJIJJIIJHHFHHHFFFFCEEEEDDDDFEEEDDDDDDDDEDDDD
@365
GCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTT
+
:??D?8<:<?C8C?CGDFFIIIB0586<BBBBBBBB-30-33267575?B@>?(23?(25))&+4+43+:5()3?B:A+:>ABB<2<2<59059(4>BB(4
@366
GATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAAT
+
@@@FFFFDFHHHHIGHIGGGHIFHIIJJFHCGJJJJJJGIJI<DGGIJHIIGHIBHGGFFBBFFGHGIGHJIGHEHEEEEHHEFFFEFFECEDCDD==CDE
@367
CTTCCTGATACTCAGTTACACACTTCTCAACTTGGAAGCTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTC
+
CCCFFFFFHHHHHJJIJIJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJJJIJIIJJJFHIJIJIJJJJJJJJHHHHFFFFFEEEEEEDDDDDDDDDD
@368
TGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCAT
+
@@CFDFFFHFHFDIGHIJIJJJIGHIJIIIIJIJIHIJJIIJGFGGGJJCHIIJJJIJGIIJGFHIEGIIJJIIGDDEGGFEFHFDDFFFCEDEEEDDDDC
@369
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHFGIJJJJJJIJJJJIJJJJIIJIIIIFHIJEHIIEGIIHIJJIIGIGJIIJFEIDHHHFHEDDFFFFFDDD3;@B;CDDEDDCDDDDDDD
@36A
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@@@FDFDFFHHHHGIGEHIJIBEFGGHIIGIIJGGIIJHGJJGHGHIEDBCGGEHIJJGICHIG@@GHHGGFFBCCCEEDECDC@@B;=?CCCCDC>@C
@36B
GTCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTAC
+
@::?D?:?F:32A2C?<C?FH<:?BFEBH8811:000)909?BF8D<*B@BF>B78.)=(.-;'6),5=B/,=;;5;<A3>5:5:?:4:4@A)))02+(4
@36C
GTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCT
+
?@@DFDDDHFBDFFGEGIIGHIGIIEEHHIIGIB9?BHF?DDHIGIIE;BCB@BHCHBAFGI=@@DDAECHHFFBDDD@DDD@DAB@BDDBDDDCEDCDCC
@36D
TGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
CCCFFFEFFHHHHJJJJJJJJJJFGHJGIJJ?FHIGJJJJJJGHIJJIJJJJJJJJJJJJJJHHBDFFFFEDEEDCCDDDDDDDDDDDDDDDEDDEEDDDD
@36E
CTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTG
+
CCCFFFFFHHHHHJIJJJJJJJJJJJIJIJCHFFDEEEDDBDDDDDDDDDDDDDCDDEEEDEEEDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDD@C
@36F
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGAC
+
CCCFFFFFHHHHHIIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJFGHJJIJJJJJJHHHHHFFFFFEEEEECDDDDDDDD<BDBDD9@CD
@36G
GCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGC
+
CCCFFFFBFHDFHIHGGIIIGIIGHHIJIGIIGGGIIGIIBEHIIIGGHHHCFFFFFCCCACC@BB@DDCDDDDDCDDDEDD:@CCCDCCDDD><@BDDDD
@36H
CTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCCAGTTCCACAGAGAAGCCCTGCTCATGACTGGT
+
CCCFFFFFHHGHHJJJIJJJJJJJJJJJIJIJJJJJIJJHIJIJJJJIJHIIHJIIJJJJJJJJJJIJJJIIIJJIJHHHEHFFFFDEEDDDDDDDDDDDD
@36I
ATCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
@CCFFFFDFHHFFHEHDHGJGHJJIGIIJIIJHEIIGEGHEGIEDBFFDFHCHIJGHEE@@@HICEG;@A='9=B3>?ADCC;@BBDDDD?A@C>CBDCC
@36J
TTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACC
+
?<?DDBDFAFDBFHIG;GHF@ABBCFCBC@G>@FHIFAAHGHCDBD?FHCEFFH<=88==F@F@CEH=7=67;@;;?@CE;>>>;@5;;;>@C>>@3(;A>
@36K
GCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGT
+
C@CFFFBEDFDHHI<CBEGGHCHIGBBEE=F??FCGEEHGE:@FGFBBBGIHC@ADHFEEHHCE;===;BCDF>@CA;C@AB@CD>CAACACBBBB@09>>
@36L
CCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCAACAATTCATACAGAACAATTCCAAATGCATATACATCTG
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJJJJJIIJJIJJJJJJJJJJGGHIJJJJJJJJJJIIJJJJJIIJJJIIJJJHHHHHHFFFFFFEEEEEEEEDD
@36M
GCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGT
+
CCCFFFFFHHHHHJJJJJJEHIIJJHHJJJJIJJJJJHHJFHIFHIJJJJJJJJJJJJIIJJJHHHHHFFFDDEEDDDDDDDDDDDEEDDDDDDDDDDDDD
@36N
CTGTATTAGCTGCTCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAAT
+
?@@DBDDEFHFDFHJJJIJJIJIIJJJJIJCFHHGGHJIJJJGGGIIIHGIAGHIGGCHHBHIIGGFE?AHCHDCDF>DFEDEEEEBBDDCCCCBCCDDDC
@36O
TCCTTCTCTTCTTTCCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCAT
+
@@CFFFFFGHFFHIGIJGDGHHGIICHHAFDGHBHGGBDHCGAD@HCHIIEIEGGGCEGFA@AEGII;CEAAE>CEB@DFFDEED>A>ABC@CCD@CD>A;
@36P
CCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHJIJJJJJJJHIJJJJJJJJJJIJJJHJIJFHIJJIIJIHHHHFFFFDEDEDDDDDDDD
@36Q
TAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGC
+
@CCFFFFFHDHDHIIJJJJJJJJJIJHIGHHEHGIGIJJJJJIJJJIIGHGIHIIJJGIHIIIJJJJJIIFHFFCHFFF@DFFEECDBBDDD5>ADDDDDD
@36R
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
CCCFFFFFHHHHHIJJEFHIJIJJJJJJJJHHIJJJIJJJIJJJJJJJJJJJIIJJJJJCFGIJJJIHHHHHFFFF?CEDACDD;?@DCDDDDDD@BDDDC
@36S
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
CCCFFFFFHHHHHJJJIJJJGGIJEIJJIIIJJIIIIJGJIIGCIIJJJJIJJIJGIJIJIIIGIHEFHFFFFFEECEA@CDDDDDCDDDCCDDEDDDDDD
@36T
CATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCT
+
@@CFFFADGFAFFIGI?EHGEAHDBHHGGGIGIFGIIDHBHHHGIIHGHGIIFBFHIEHI@GIIIAH8?CDFEFFE;@CE@?B=BCC@CCC5>CCCACC?<
@36U
GTTTCTTTATGTTATAACATGTCTGAGTGTCCTAATTAAAATCTATTAAACTAACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCC
+
CCCFFFDFFFFFFIAHIIHIIHE>HHICHDHFHHHHIIGIIIIIIGIFIIIDGIIEHIIIIGHGIGGGHIIIIIIIIIIIIIICDCCHEEBEFDDB>CC
@36V
CTCTGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@CCAFFFFHDDFFIIEGEEGHIGIIGHEGIGIBFEGGIFIHGGHGIGHG>CGHID;FEGIIIIGDE9=BDDDC>CCBDDDDDDCCDDDDDDDCAABD@BBC
@36W
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
@@@FDFFF?CFFHIFHGICGIIIIIIIIIIIIIIGIIIGIIGGI@BHGIIHIIIEHEEAEHHEBDFFFAC@@AC;ACCCCCCCCCDDDD<CCD@CCCCC>C
@36X
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
?@@BDDDDDBFDFI=C?A3AC9AA<F:E@GIIII@?<?G@B?D>GCB@F>FFDFF<FC7C=F3=.7=CD6=9=88?@B>A@@5>?<<858?B<@:A883+
@36Y
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCC
+
CCCFFFFDHHHHHJJJJJIJJJJJIJJJJHIIJJJJFHGIJIJIJJJJJJJJJFIJJGHIJ5@EHEHHHFFF=ACEECDDDDDDDCDDDDDDDD9@DDDDD
@36Z
GGTTGTAACCCCCTGTGCTAGATTGAGGTCGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCAT
+
@C@FFFFFGHHGGIIHIIIJJIJJJIIJJ3DGGGIGGHIJIIHIJJJIIIJJIJJJJIIIGIHHDEDDD@CED>ACDDCCDDBDBCDCDDDDDDDDDDD
@370
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIJJJIJIJHHHHFFFFFFEEEEEEEDDDD8?BD5ADDEDDDDD
@371
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCC
+
@CCDFFFBFHHHHJJJIIGGEIJJJJJIJIJIIGJIGCIGGIGGHIEBBFEDF?=BG=FAG@GHEAHFHFFE;ACCC>CCCDDBDDDDDDDDDD@>DDACD
@372
CTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCC
+
@@<DA=@DFD>BF>FGEG?A<C:EHCAEBEGCFB@BFF5@ACACHIIFFCAHEEEE;?C@>@BB8?C5AC@A?9>@CDDC>@@ACDDEDDCB?<58A.9>
@373
CCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCT
+
CCCFFFFFGHHHHJJJHIJHJJJJJJJJJJJJJJJJJIJIIJJJHHHHFFFFDDEED@CBDDDDDDDEEEDDDDDDDCCDDDDBDDCDDDDDDDDDDDDDD
@374
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
CCCFFDFFHFHHHJBHIJJJIJJGGHJH;EFHIHHIJIIJJJJJJJEIEIIIEHIJHIHHHHHFFFFF@CEECDDDDCCDDDDDDDDDD9@CDCCDDDDCD
@375
CCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJGGHIJJJJJJJJJJJJJJJJJJJJJHHJHHIJIIIJJIJJJJJJIJHHHHHHFFFFFFFEEEEEE>CD
@376
CAGCAGGATGAACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAAT
+
@@@DDDDD<DDHFHD:8<CGIB@BFGB9BB;FIC=FAFHIGHC@;AHEEB8?=AC>@>@AC:?B38?>ACDC::>C>>@D@AC>@@BBBCAAD:>CC42?>
@377
AGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCAC
+
??<BDDBD?F?:AEGHIGHECCHIBHDHGHGHII?E@BDCFHCC6FFBEHD8BBCFF=@=@G.@==D;?EC.;B@B@@;C6>>;;,;>@>CCA>A>?CB
@378
CCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCC
+
@@@FDFDFABDHDHFHAEFHHBFHICHEGIFDA@DDHGIIC?FAGIGGIBDAEB>ACC?ABCBBBBCC@??BB9<AB8?<ACDECB@CCCABBB9A<8+:>
@379
GCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGGGCTTGGCTGT
+
CC@FFFFFGGHGHJJJJJIJJJJJJJ?FH@GHGIDDFHFFHIGHHIIHGIJGIIIFHEFFFFECEEDDDCDDDDCDCCDDEECCCCDD?@>9B>BDCD<
@37A
GGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCC
+
CCCFFFDFHHHHGIJJJDDDDCDDDDD8?C@CDEEDDDDDDDDDBDDDDDDDDCDDDDDC>ACDDDDDDDDDDDBDCDDDCDDDCDDDDD>CDCCDCD>CC
@37B
GCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCT
+
@CCBDFFDHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJHHIJJJJJJJJIJJJJJJJJJJIJJJJJJIGIJHHHHHHHFEFFFFFEEEEEDDDDDE
@37C
CTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJIJGIJJIJJJJJJJGIHHHIJJIJJJJJIJFEHHHHHHFFFFEEEEEDDDEE
@37D
CGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGT
+
@@@FDDFFGHHHGGIIHIIIIIJJJGIGEGHIIJJEHIIJJFHGGHHGGCFHDDFHHIIII4@BH=BC?>@C;>ABD?DBB?BDACBDDCDD<@@CCCCDD
@37E
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
:8;;+=:1<DDHH@H<EE=FH:CBAEEHIIEDF??DFFD<FF>FHBAA@;@@DAE>ECEHH<ED>BD;B?;A>>>;;;8@B:?>A(>9:A@>484@CCC@
@37F
CGCTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTC
+
CC@FFFFFGHGHGJHIJJJJJIJJJJJJIJJJJJIJJGGIJJGIIJJJJJIJBFGGHIGGIJJJJIIIIHFHHHHFFEDEDDDDDDCDDDDDDDEDDDEDD
@37G
GCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACT
+
@@@FFFFFHFHFHIJJIJIJJJIIJJHIJIJJJIJJHIGIJJJJIIIIJJJJIIIIIIJJJCHIJJIIIGIGJGIGHIIIGEFHHFFFFDDECEDDCBDDD
@37H
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
@@@=BDBDHBH?FIGGABFCHGBFHD@GE1?@?BBFBBFFDBGDHGECGCHE;CC@?EB=B(;CACACCACC:@@>95:ACCABD:::4:@@??@CCB>><
@37I
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
CBCFFFFFHHHHHJJJJJJJJJCHIJJJJJJJJJIJJIJJJJJIJJJJJJIJJIJJJJJJJJJJGIJJJJIGIJHHHHHHFFBDDBCDDDDDEEDDDEEDC
@37J
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHH=BDBDDDDDDDDBDDDDDDDDDDDDDDDDDDDDDDDD
@37K
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGG
+
@@CFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJJJIJJJJJJJIIJJJJJJHHHHFFFFDD>BD?BD2?CDDDDEDDDDCCDCBD
@37L
CTGTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCAT
+
@@CDFFFFFFHHHJJIGIGIHEHGIJIGCHGHHIIGIGIGIIJIIIIIEGHJIJIJHIIIIJFIFHAFHIJJHFDDEECDCACCDDDDDDBDDDDDDDDDC
@37M
CTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCC
+
@@@FA@DF>FFHGDFHEHIIGGGIIIGGGCGGEGHIICGEHIGIIICHIIGHGIGIFHFHEEDFFFFFEECEACCBBCCCCCCCCCCACCCCBCCCCBBBB
@37N
CTGCTCTGTTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCC
+
@CCFFFFFHHFDHIIIIHIGGIGIIIGIJIIIJIJGIIIIGIJJJGGHIIIIJJJJJHIIJGIJGIG@EHIHHF9>BB;ACCDCD;@ADD?BBB@DCDADD
@37O
CTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJIJIIJJJJJJJJJJJJJHIIJJJIIJJJJJGHHCHHFFFFFEDEEEEEDDCDCDDDDDDDDDDDCDDDD
@37P
TGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
CCBFFFFFHHHHHJJJJJJEHIJGHJJJJJGHIJJJIJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEDEEEDDDDDDDDCDDDEDDDDDDDDDDDDDDDD
@37Q
ATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTT
+
@@@DDDD?F?A??EGBF<@FBBFECD@GDGF@GFIII<?B?DDFF9FFFFFADFDEFEAEF>@@;B3;AC@A@BBB3;AA@:>?AAA@ABABBAB@<@B?:
@37R
GCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTT
+
CCCFFFFFHHHHHJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIJIIJIJHIJJJJIJGIGIJJJIGFFHHGADFFDFFEFEEEDEEDDD
@37S
CTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGG
+
@CCFDEFFHFFF<E?DDHGGHEDEFGIGGHIIIIIIGGIIIIIII;AGGIGIIIIICGHHGGGHFFBCACECCDDDDDDDDD@>CDCDDDDEDDC?C>ABD
@37T
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
@<@DDDDDHHHGDGGGHEIIIIIICE=EFEFGHGGGHE@GHIIIIHIIIIGI<A@BHIIIGIIH>:BD@;B@;.;A>A@??A:@CD@AACDA:ADDE>CCC
@37U
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGC
+
CCCFFFFDHHHHGJJJJJJJJJJJJIJIJIJIIDGIIJJFHIIJJIJJJJJJJJDHGIJHHGHFHFFFFEEEDDEDDDDDEDDDCDDDEDDDDDDDDDDDD
@37V
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
B@@FFFBDHFHHHHIJIJHIIJJJGHIFHIFHIJJJJJJJJJJJJJJJJJJJJJJJJJJHIJIHHHFFFFDEEEEEDDDDDDDDBDDDCCDDDCCDDEEE
@37W
GGCGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTT
+
CCCFFFFFHHHHGEGHGGHGIGHIJJIJIIGGJJIHFHIIIGFHHHGGHHFFFFDFEEACDDBDDDDBBDBDDDDCCDDDDCDDEDDBDBDDDDDDDBDDD
@37X
CTCCATGCTTCATGTATTCAAAGACCATGATGAGGGGGTCCCCATCGCCGCACACTCCATAGAACTTGACAATGTGCTCATGCTGCAGGTTGGTGAGCAGC
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJHHJJJIJJJJJJHHFFFEEEEEDDDDDDDDDDDDDDDEDDDDDCDDDDDDDDDDDBDDDDDDD
@37Y
CACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTA
+
CCCFFFFFHHHHHJJJJIIJIJJJGJJJIIJJJIJJJJJJJJJIJJJHIIIFHIJIJ@GHIGIIIJHDDEHHFHFFFFFEDEECEDDDDDDEDDDBBDCD
@37Z
ATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGG
+
CCCFFFEFHGHHBEGHJBHEDBHHIEHEHIJHEGDDGGIEGIGGCFHGHGHIEGFHIGGEGIGIIJJHHGGHIGGIG@FEHEHIEHCHHEEEEEDDDDCD
@380
GGTGGCTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
?<=?DBEFFDDHFGHGICE@@AHHGIIIIIIIIFG<DHHGIIIIIIIIIIIFGEGAGGIGIEACGHFHGFBDCB>BBCCCACCCCC:>BCDCC>A:ACB
@381
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@@BDD0AFD?FA?F<;F?F@@GGE?GFB4?F?9?8?BDBB?BB8==FB=C@@EIA=D=7===??<@@>B>>@:,(8@588>4::@4@::44@??955(++
@382
CCAAATCAGAATTCCAAAAGACCATACATCAGATTGAGTAGTGAAGATTCCATCCATCAAACTTTCTGGAGCCATCCACCGAACTGGGAGCAGGCCTTCCC
+
@@@;D?DD<CCC?GG@:?F3:CGIBHBBA?FGBFEFEE:DG??CB?DCFFG<F?8?BF@FIC<=B=8=78(.;D=CEEFCAD83?>;(2,;?55;BBB>?B
@383
GGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CC@FFFFFHHHHGHHIHHIJJJIJJHIJJGIJJJJJJJJJJJJJIIHIJJJJJJJIJJHHHFFFFFEEDEACDDDDACDCCDDDDCDDDDDACDEDCDDDD
@384
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTG
+
CC@FFFFFHHHGGJIJJIAEEDGIIIJJIGIJJIJFIEIIIJIIIJJJIIIJJJJIIJIJJJJIGGIJIGGHGHHFFFFFECECACEBDDDDEDDDDDDCC
@385
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
??;?D?4+=CBCD+2<E>>:FB>@:3F?9A?)C30:C9CD?9?0:?9D??<DEA<D*?=B38BA77A)/>AA1)-5,3.6;;(>36(;;AA3(5(5,(59;
@386
GAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGT
+
CCCFFADFHHHGGJJJIJJJJJJJIJJIJJJIJJIJJJJJJJJIJJJJJJJIIIJJGIJJJJJJIIJIJJJAHCHHHCFFDDDDCDDDEEDDDD<@DDDD?
@387
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
CCCFFDFDHHGFHHGJEIGGIIIHJJGHJHGIIIJIIJJJIJJJIDHIGIIIJJJJ;=B9;BCECECBDDDDDCDACDDDDCCDDB@BBDDDCCDCDDDDD
@388
GTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATG
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJIJJJJIJJJJJIJJJJGHGHIJJJJJJJJJJJJIJJJJJHHHHHHFFFBBDEEEEDDDDFDDDDDDDDD
@389
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
CCCFFFFFHHHHGJJIJJJJJJJJJJIJJJIJJJJJJJJJJGHHHJJIJJIIJJJFHIJIJHIIJJJJJJGJHHHHHHFFFDDDDD@CCEDDDDDDDDDDD
@38A
CACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACTAGGAAATC
+
@@CFDDFDHHGGHEGGIIJJEIHGIIJGIIIGIGIJJHHIIIIIHIJGEDHIIIJIGEIIGHIJJJIDGEHFHHHFEDFFFFDFFEEEEEDDCACCCCDDD
@38B
GCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTG
+
CCCFFFFFHHHGHIIJDEGHIIJIJJJJJJIJJJJIJJJJJJJJIJJJJJJJJJJJIJJJHHHHFFFDCEEEEEDDDDDDEEDDDDDDDDDDDDEDDCDBB
@38C
GTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAACCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
@=@DFDADFHFDHIBHIIEIGCC@CEHGH>C*:CFGGG@GGHGGFHCCDBHI<FE;;@FICHE@@DAHC?EC>DFDFEC>>A==>?A?532,2808>CCCC
@38D
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHJJJJIJJJJIIJJJJJJJJIIJJJJJIIJJGIJJJJHHHHHFFFFEEEEEED
@38E
GGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATT
+
BBCADDDFHHHHHJIJJJJJJJJJIIJJJJJJJJJJHIIIJJJJJJJHHHHHHHFFFFEDDCDDDDDDDDDDDCDEED>CDDDEEEEEDDDDDDDDDDDDD
@38F
GGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTG
+
CCCFFFFFHHHHHJJJJJJJFHHIJJJJJIJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJHIIJIGJJJJHHFFFFEEEEEEEDDDDDDDDDDEEFEDDD
@38G
CCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCT
+
CCCFFFFFCFHFHHJGIGGIHJHGEFFHHIGIGCGHIJJJJJJIJJJJGIGIGIIJEGIHGHADFFFFFCDDD?@BDD@BBDDDBBDDDDDDDDDDDDDDB
@38H
AGCTATAGCTTGCTGGGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTC
+
C@CFFFFFHGFHHJJJJJJJIIJJJJFHGIIGHIIJJJJJHIIJJJJJJHGGFHHIFEGHIJJJJGIHHGHHHFFEDDECCDDDBDDB<C@ADBDDBDD
@38I
TAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGG
+
<?;B=B,2ACDFAFFF<EHF<FBAEED4AEFCED13CC)?DE@FE>D)07.?)))8883=;@@==.=@7=A?>)=;B;7..(.5;?:=@=;;>@BBBBB8.
@38J
GAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTG
+
@@@FF+ADHFDHFEIF?EGEHFGCHIGHICGIIIIGGJ@GGGFGGGIIIHIGDHGCBHGIFHGFGEE@BDFFDCCEEEDDDDCCDEDDCDDDDDD?@B9@B
@38K
GTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGC
+
CCCFFFFFHHHHHJJJIHJJJJJJJJJJHIIGJJJJJHIIHIJJJJJJJJJIJJJJJJJJJJ=EHHHHEHHFFFFFDDEEEDEFDDDDDDDDCDEDBCDD
@38L
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJIHHHFFDDDEEEDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@38M
GACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAATCGGCTGTGTAGAGGAAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJGHGIJJJJIJIJJJHHIJJJJIJJJJHHHHHHFFF.7?ADDDDDDDEDEDDBDD
@38N
TTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGACGGGGAGCTTGTTGATGTCC
+
@@@FFFFFHHGCBGIIGFHGIGIGGEHGGGIGIIGBGGEHIGHEGHFHEBFFFDBCBC@CECBD@@BBDDD?A?CCCCD?@>BBDBBBDDCCBDDDDDECD
@38O
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTGGGAGGGTAGGATGGAGGTGC
+
@@@DDDDDB6FB<EHGFGH@FBFHIIBBGCDEG?CFHHICHIIIBHGGGIHIIIIBFGG@EA.=.7=7?B@B:;>;>AC.(,;(8=@5>BB>AC@C<<22(
@38P
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@@@DDDDDHDBF?<AEGGH+3@CFGGBFHI:D?DDGCGCEAGF9DB9D??DHHIAGHGB=C;@@G@=7;ABEDB;;;;;>A=@CA>A@A?CAA@CC=><
@38Q
GGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATAC
+
CCCFFFFFGHHHHIJIHIIIIIIJIJJIJJJJEIGJJJJGIIIIIGJJIIJJJJIIJIJJIHHFFFFDEEEEEEDDDDDDDDDDDDDDDDDDDDDCDDDED
@38R
CGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCGCCTTTTCTAACTCTTCACA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJIJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFF(;ACDDDDDEEDDDDDDEDD
@38S
GTCTCCATGCTTCATGTATTCAAAGACCATGATGAGGGGGTCCCCATCGCCGCACACTCCATAGAACTTGACAATGTGCTCATGCTGCAGGTTGGTGAGC
+
@:?DB:ADBD?DBGEGGEIBC>B?+A<<<A93<4CG;EF6@68BFEFICCFAB>B@@@@;5>>;;>AAA:::5@@5(,;@B>@:@A::>ABBA3522:<?
@38T
ATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCC
+
CCCFFFFFHHHGHJJJJJJJFIIIJIJJJJJJGHFHIIJJJJJJJJGJIJJJJJJIJJJJJJJJGJJJJJJIJJIJHHHHEDFFFFFEECEEEDDDDDDDD
@38U
CAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDBD
@38V
AAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJJIJIJJJJJJJJJJIJJJIJIHHHHHHDDEDFFECCEEEEDDDDDDDD
@38W
GTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGT
+
BB@DFFFDFHDFFIJJIIJJJJIIJEGGHJJGIGIGEIJJIIJJGIGIJIHIGHHHHHFFFBDEEEEEDDDDCCBD?DBB)0<@CC@CD?CDCDCDDD9
@38X
TCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTT
+
@@@FFEFDDHHHFIJJJEIHEGG;GHHIIIHIIIIJIIIJJJJIJIIIGBGHI@DFEAA@FHGHGIEEHDGGEECEHFFFBDCC>AC>@EEFD@DCC@CCC
@38Y
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIJJJJJJJJIJJJJJAEFDBEEEEDDCDDDDDDDDDDDDDDDDDDDDDDDDD
@38Z
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@@@FBDFFHBFFHGIIGGGIIIADHIIIGEHGIIIGIIGBBGHFIIIIGGIEIIIBDFHIIIGIEGGIIHHHEHHCEDFFFDCDEEDCCC@;@@BDD@ACA
@390
GGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFFFFHHHHHGHIIJJJJJJJJHIIJJJIJJJJJJJJJJJIJJIHJJJJIJIJJJHHGFFFFFEEEECCDDDDCDDCCCDDDCDDDDD<CCDDDDDDD
@391
TGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGCGCCTGGGCAATGCCGTGGAAGTC
+
@@@DDDDDF?DCFH?;DH@GIHDFHD?;??::?DGG9DF0?FEECDBGFGGIAFG<GEFHE@EDE8=95;C??=@CCCBBB-<@?B?BCCCCB9B@<C?:4
@392
AAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCC
+
@@@FDFFFCFHFHIIIGIIIEGGIGFHIIBFHIGHEGCHIIIFIGIIIIIIIIIIIIICGIDCHIEHFGH@DHHFD@DDBCDDDCDDD@BDBBBBDBDDD
@393
GCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTAC
+
CCCFFFFFHHHHHJJJJJJJJJJAFHIHIJGIIIJJJJJJJJIJHJJJJJJJJJJH<BCEEEEDDDDDEDDDDCDDDDCDDDDDDDDDDDDDDCDEED>CD
@394
CTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAGCCATGGGGGTACCTCTGTCATCTCCCCACATGGCTCCTGAAGAGCCTTCCCAGGGCACTGCTAA
+
C@@DFDFFFHFHHJJJBGHGGGIGHIJIJIJIIIGEHHHFHGGJJFBHIJJIIGGIGGGIHHHGFFCBEDCEDCACDCCACBCCDDDCCBBBDDDDDCCD
@395
CTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGAC
+
CCCFFFFFHHHHHJJJJIJJJJIJJJJJJHIIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIIJJIJJJJJJIHHHHHHHFFFDFFFEEEEEEEDDDDDDD
@396
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
<@@FFFFFHHFFHGGIJJJIJIJJIGHJJJDGGFHIGIJJJJJJHIEIJIJIJJIEHIJJJJJJIJGIGEHHFEF@BCDEEDBDDDDCCCC@CBDDDD2
@397
TGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTC
+
@@@FFDDFGHHGHJGGIIJJJDGHIIHGIGGIJJJJJIIIHHGGIJEHIDIIIJJIJIIJIJJIJHGHGHFFFFFEDEDDDBDDDDDDDDEDDDDECDDDD
@398
CTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGG
+
CC@FFDFFGHHHFCFBGGHGGGGIIEEHGJIJJJIBHDDF@FEGEFFHHJEHIIIHFHHFFF?ACEC;ACDCCCDCCCDCCCDDDDCCCCDDDDDDDCDDD
@399
CTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTCAGGCATTGAACCAGGCACTGCGCATTCACAAAACCACTGCAGGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJHHHFFFDEEEEEDDDDDDDDDDDDD
@39A
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJIJJIJHHHHHFFFFFFFDDD9=BDBDDDEDDCDDDDDDD
@39B
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAAT
+
CCCFFFFFHHHFHJJJJJJJJJJJJJIJJIIIJIJJJIJJIIJJIJJJJIJIJJJGHJJJJJJGHHHHHFFFFFFDECEEDDDDDDDDEEEEDDDDDCDDE
@39C
CGGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJEGIJJIJIIJJJJJIJFGIIIJJHIJIJIGIIIIIIHHHFHFFFFFECEEEDCD
@39D
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
CBCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJIJIJJJHHHHFFFFFFDEEEEEEDDDD;BDD@CCDECDDDD
@39E
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
CCCFFFDDDFHHHJJJJJJJGHIIJJJJJJJJJJIJJJIJJJIJJJJJJIIIJJHHJIIJJIGGIJ@GGIEHHF;BCDCDEDCDD<BDDDDDDDDCDDDDD
@39F
GAAAGGTGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGA
+
CCCFFFDFHHHHHJIJIIIJJJJJJJJJJJJJJJJJJHGHHHGFFFFFFEEDD@DDDDDDDDEDDEDCDDDDDDDDDDDDDDCDDDDDD<ADDDDDDDD
@39G
CTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTC
+
@B@DDDDFHHHHFGGIJHIJJJJJJJJIIIJJJJJJJIIGIIIIJJIJJIJIJJJJJJJJIJJJHIIEIHJJJIIIIJJHHHHGHFFFFFFEEEEEEEDCD
@39H
CTGTCATCTCCCCACATGGCTCCTGAAGAGCCTTCCCAGGGCACTGCTAAAGGCTCCTTCCCTTGAGGAAGCACTCCACGACCCCCTGTTTGTTGTCCTTT
+
;??AB?DD?FHDDCG?<<3<AAFBGIE?C??CCGIII@H??F?GD???FDB8)8=CCDHGDEAC@====?;BEE>>;>C;;;?=?=<?:>@9+<<9:A@A@
@39I
TCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGG
+
@@@DDEFFHHFHHAGHIIGIJEGIJGJJJJIJGJJJEHGGIJIABHGGGHJIGGCHHHFFDCCCCC>CCC>CBACDCCCDDD?CDCDDBDDDDDCACCDDD
@39J
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
@@@DDDDDFDFFFGA@E<FIIEGACF@EFEGGIGDDAB0BBDBBDA0=BC===@CFH5======???;;=@ACCCCBBB,88:5:>?CCB@ACCACB?BB>
@39K
CTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTG
+
?BBDDDFDHFHHGGHIGIIIJJIJJGHEHIJJIIEIEGIJHBGGEGHIGIJFGIEHIHEGGHI@F@FIIGDHIGGIIIGCEHGHHFF
@39L
TAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTG
+
C@CFFFDDHGHHHJJJIJJJGGJJIJJJIGIIIJGEGIGIEIIIJIGGHIIIJJJIGHHIIIJIHFHGIJIIJJJJJIIJJIJHHFHHHHFEFFFFFE
@39M
CTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGT
+
?@@DFFDDHGDD?FGDHDE6@FGFIICGHCHEGIGIHGHFDCBBCCBC?CCCBCDCCABCCCBCCCA?;@9@;C>CACCCCCCCCCCCCCCCCBBC@CCCC
@39N
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@@@FFDBDFH<FFBGIGHGIIGGGGG@?FGHEHGEDDFAHHIDEHGBDEFHGAF<<BFHIIIAHIEEHHDDDEBE;CAACCCCCCCC95>@AA==(+<@CC
@39O
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
CCCFFFFFHHHHHJJJJJJJJJEIJJJHHIHIJJJJJJJJJIJJJJJJIJIJJJJJJJJJJIJHGHIGHHDECDDDEEEEDDDDCDD?CDDCDDD8A@BCC
@39P
GTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
@@@DD?DDFFFDA@GGDHCGCH?FCDBEHCGFFEB@DDD@FGIDGGGGGDCFFEHII>GHGGICEEGFHCEDD;>CC>>A>;>;@C:=@B3;<<BCCCA
@39Q
CGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGAC
+
@@@FFDDEDFAF?GF>E<AIHIGIBGIIBG>H?FFAAGG>BGHIBDFCHGBEGGG<DHHE?;FBF=@CF==FHGGEGIGHG:?AEFE@>;>@@;>B@>55=
@39R
CATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCT
+
@<=DFDDDHDHHDGBGEHCBFFHEECC??B>H@BE?1?CDA:B99?BDHDGIGEH<C88BDHGH@@=53>?3>;@:@CCC:;A>CCC?8AC=B<@BCCCC?
@39S
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGCAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
???DD3:+=2AA;<?<E:AEFDE+A2ABF?E:):)0(/(?B=@)8=A(;-5A>AC:;;=AD@:A@A>AAA>A??>:::A:>A>5>4:>AA4>>:>AAAAAA
@39T
GCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTG
+
@@@DFDFDHFDFFH@FHHIIG@FHIGGIECEGGGGIGGFDHG9BGGGE;;BFHIGG<@;F=@E:7@DCCFBHEFGFD@BCACCECD@ACCACC?@ACBC
@39U
TCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCA
+
@@@DDA?DFHHHDBDGHEIGGHFGHGAGIFGEGDHGFADAEEFGACHHHIIFIGIIEGGGH<BDBB;@@C@ACCCCB?B@BCDCDCCCDDDDDBBBBDDD
@39V
TTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJIJIJJIJIJIHHIIIIJIIJJGDHGHIIIJJJJJJIJJIJGIJJJHGHIIIJGHJJGIJJHHHEFFFDFBEEEEC
@39W
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
;@@?BADDDDFDFFFFIIE>@>@F@FFFFE?@DCCFFF>FIFEFFFF>B*9<DFIII>FFGFECF>FGDFBABE?BB?>A((;;>(.;AAAB3>7@B@8@B
@39X
CGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAA
+
C@CFFFFDFHHHHIJJJHJIJJIII<CEHHHHEGFHGBFCEHIJJJCHHJJJGG@GCHHIIJJJIGHGJJIG@GC@DHFHHHHFFEFFFAAECECDADCD
@39Y
GTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGC
+
C@@FDDFCB6@ABCCCC8ACBCCDECCCBCACCBBCBBBACCCD@AA>AC9@A9A@CCCCCC;;@C:>ACCCCC>:<?CC:AA:@AC>A@CCBCC3:CDDA
@39Z
CAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGG
+
@??DDDDDHBH>FCGGH<CH9EEHHGEGFICEDGIIIIIAHGIIIICHGGGHHHFEEDAA@BC?B?CCCCCCBCBBACCCCC>CCCBBBBBB>BBCCDCCC
@3A0
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCA
+
@@@=B;BBFFFBHIEGBAEB?BHEHEHIFEGIDDF9CDFEDEEBAG6DE<BGF:GHDIDGG@DGEEACEHEDEB@>C>@BCCBCCCC@CC:5:;>:A?@@
@3A1
CTTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
?@;+AA?DFDDD?FDF:GGC?:FHIIC@1)1?GDB@DGCFFFBF>@FFF9@E@=7;66-5,,;;;;AA>A;A;A@A?@@BAADA@::AAB::9<8>AB9:+
@3A2
TTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATAC
+
BCCFFFBDHGHHHJJJJJJIJJJAGHIJIJJJJJJJJJIJJJJJJJJJJJJJJJIJIIJJJJJJJJJJJIEIIHHHHHHFFFFFFFEEEEEDCDDDDDDD
@3A3
GGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
CCCFFFFFHHHHHJJJJJJJIIHIJJJJJJJFHGJJHIJJIJIJJJJJJJJJJJJIIJJHHHHFFDFFFCEEDDDB?A;ACDDDDDECDDDDDDDDCCDD
@3A4
ATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGG
+
CCCFFFFFHHHHHJHJJJHGIJJHIIJJJJJJJJJJJIJJJJJJJJJIJIJJJIJJJJJJHHHFF>CEFEEEEEDEDDDDDDDDDDDCCCDDDDDDDDBDD
@3A5
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
CC@FDDFDFFDFFEGIEIHCHE?GIGGIBGH@GEHCH<@DHCCHA?BGGF@FHH9CHIBDCGBH5=<B9CEEDACACD?<?@D<B@>>CABCCCCC>:>>C
@3A6
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
B@BFFFDDHHHHHJJJGHIHHGIJIJJIIJJJJJIJJJJIIIJJIJJIIIJJIJJJJJHHHHHFFF=BB>CDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3A7
CTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJIIIJJJJJIIJJJJJJJIIJJJJJIJIIGIHFHFFFF;>B;@D8?CDDDCDDDDDCCD>@D9
@3A8
CTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTTCCCATACATCTCATCCAGC
+
@@@D=DDBHDAF@H@HIDGG@EFHIGGEG@GGG<::9C9CCGGBDG?FCHEEAGBGEGICGCBHIIFE>F7@FA37@=CC7)7??;??C;6>;>ADCC;A>
@3A9
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHGHHHJIIJIJEHIIGGHHIIIJJJFHIIJJJJJJIIIJCHIJJJJJJJJIIIHFHHHHDEFC@CAB>ACDDCCCDCEDDDDCDDDDDBCD
@3AA
CTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCAC
+
@@?FFDFFHHFHHEFEGGDCCHD8FFGHIEGGHIEEHGICGGIGGAFGGGGGGHGF>FIGGIGHD.:BBBB9=>C@@;>CCCA;AC5<@=CCC@CCC::@A
@3AB
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGC
+
CCCFFF<DHCFFGIIJJJJJJEGDGEHGHIJGEBGGIJJDFIHGIGIGIIIJJJCCGHEHHGHEHFBDEDD>?BD@ACDCDCDDCCACDECDDDDDCCDDD
@3AC
GTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGC
+
CCCFFFFFHHHHHJJJBDDDCDDDD;?BDDD5<BDEEDEDDDDD5BDDDD<BD?ADDDDDDDCACCEDCDDDDDDDDDDCDDDDDDBDDBBDCCCDDDDD
@3AD
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@CCFF@DFHGHFDHGIIJGIGEIIIJJJJIJIJEAHIJFIGGHIIIGIIJJJIJIIIJHHGHFFFF9>@>CDDCDDBDBDDDDDDDDDDDDCDDDB9@DDC
@3AE
ATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGT
+
CCCFFFFFHHHDDDDDDDDDDCDDDDEEEDDDDCDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDBDDDDDDDDDDDDDDDDDCCDCDDCDCDDDDDD?
@3AF
CCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGG
+
??;?D?DD>?ADBEGIGHHHIIIIII>??DEFHGGGIII@@FF@DGHGIGHBFCFCCFHCHEGEHHEEEBDDECCAB;?@CC5:C@5@AA@A@CBBB?4@C
@3AG
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJJIJJFGIIIIJJJJJJJJJJJJJJJJJIIJJJJJHHHFFFFFFEEEEDEDDDDDDDEEFDDDDDDDDDDDDDDDDDDDDD
@3AH
GCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACT
+
?<?7B80BDD,A)1A<E@FFFIDI<EE?9?D?DDDA><D<<B@DD;DDDBD>C)8@==.=@ACAC:=7==A>=?D@AA@@3@;;-;;>5>>=<9??AA:4>
@3AI
CTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTG
+
??8D:BDD??<D:?AAEDB@<FFI>F>??A9E3CB?E9?@DED@D<B@BD???9B>DID;BB;=B=;;;CE;ADE;A;C?;AA77;A
@3AJ
GTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTC
+
@@CFFDDFGHGHHIJJJJJHGIJJJJIJJJJFHHIJJJJIJJIJJJJJJJIJGGHEFDDDDDDDDDCDDDDED>ACCCDEEEEDDDDDDCBDDBDDEEEDC
@3AK
AGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTC
+
<@CDFFDDDFHFGGHIIEIFHIIIGB@FEEHHIIGHGIBHDGBFGFDGGGGIIGCGGHHGIAHI=C@;A=?HFEDDDDCEEEED?@>55(,5@C@B?B@?A
@3AL
GTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGT
+
B@@FDFFFGHHHHIIJJJJJJJJJJIJJIJHGHGHFHIIJJJJIIJJGHIIFGIJ-@FHDHHIGHH?BDFF?CCEEEBBDBDDDDDDD;BDDCDDDDDD:
@3AM
GATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCC
+
CCCFFFFFHHHHHJJGGIJIJJJJJHJIIJJGIIIGJJJJIJJJJIIIIIJ?FGFHIEHGIHHHHHHGF@BE;?C9ACDEEDDDDDCDDDDDDDDDDDDDD
@3AN
CAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTG
+
B@CFDDFFFFHGHIJJJJJJIIJJIJJIGHEHIJJJJJIIGIIJGJJIIJGGHGHGGHIHIJJJIAHFHFHFFFFFCEE>AEDDDDCCADDDDCCABDC<5
@3AO
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCT
+
@@CFDEFFHHHHHIIIHHIJJGIIJJI@EHHJIIIIIGIJJJJGIIJHGGGIJJIJJIIJHHHFFCEEEAEDEEDD3;@;CDDCCDBD>BDDDDDDDDDDC
@3AP
TTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTC
+
@@@A:?DDDFFAFFGIEGHFI3AAFH@FCCEHFGEFIIID<D?GCGAGFFGBFBEFFIGFFIGI4C)BF;FFBFEE=CA>CEEC>CA=@DD>BDDBAC6>>
@3AQ
TGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCT
+
@CCFDFFDHHHHAFGIGGIIEGIGGGHIFHGEIIIGIIIIJIJJIFHHFGHDEF;A@CCCEDEEDDDDDCDBCDDDDDDCEDDDDDDDDDCDCDDDDDAAC
@3AR
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
CCCFFFFFHHHHHJJIIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJHHH?BDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3AS
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
CCCFFFFFHHHHHJJJJIJJIIJJIJJIJJJJIIHJJJJJJIJJJGIJIJJJJ@GGIGJHHHHHHFFFEFFDDEDDDDDEDDDDDDDDEDDCDDDDCDDDD
@3AT
CTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJGIIIJJJJJJJJJJJIJJJJJJJJJJJJJJJ
@3AU
GTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTC
+
CCCFFFFFHHHHHJJJJJJIIJJJJJJJJJJHIJJJJJJJJJHJJJJJJJJJHHHFFDDEDDDDDDDDDDEED>CDDDDEEEEDDDDDDDDDDDDDEEEDD
@3AV
GTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGC
+
?????DB?<DBDD:;<2,<4:F@9CFEEBFE<FE9C@*?9E@9B@*?:*???@?D>B?DB?>**088))8==C;((.=@;A;?3?A7);;;;(;>;>3>5(
@3AW
CCCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGAT
+
CCCFFFFFHHHHGJGIGIHIIHHIJJJJIIIIJIIJJJJIJJJJJJJJJJJJJIJIJEHHHHFFFF;@AEE>CEDBBDDDDDDBDDDDDDDDDDDCDDDDC
@3AX
GGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTA
+
@B@BDFFFHHHHHJJIJIHIIJJJJJJJJJJGJEHIJJIIJJIJJJJJJJJJJJJJJJJJJJJBFHEHJJHHHHHHHFFFFFFDEEDDDDDDDDDDBBDD
@3AY
CCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJIIJIIJJIJIIJIIGGIDIGEFHGHGHIIJJJIJJIJJJJJIJIGGGGIJJGHHHFFFFFEEECCEEEDE
@3AZ
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
@@<BDDD?<D?CA:2<FGFHIIIB?HH><FFFDGE<?B9BFFF8C@=BCF@F.@=7)@C>9AED?>?BDCAB>;ABB;;ABB?@<;@@:AB@BA:@BBAB
@3B0
CCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAA
+
@@@DDDDDDHD?FBFHGGH@;FHFFHII<HHHII>FFHGFHIGH9?BDBDEHHG>BFDDGGCCHGBFG>FHGE@C=@ACHAEEDCDEDE;>@@CCCCCCC
@3B1
TGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
@@@BBDDDFHHFHEGG?FHGHID<FHHFIIIAGB?DFHHIGIEHHHEHHDHHGDH<=CHGGGHG@GHEF@DEEDC6>ACCECCCCCBCC@CCCDC@@@CC
@3B2
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGC
+
CCCFFFFDDDDDDDDDDCCDEEEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDCCDDDDCCDCDDDDDDDDDDD<CDEED
@3B3
CCTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTC
+
CCCFFFFFHHHHHHIJJJJIHGHIJJJJJIIJJIJIJIJJJIJJJJJJJJJJJJJHIGGIIHJIIJJJJJIJJJJJJJIJJIIIJHHHGHFFFFFFEEDEE
@3B4
GTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGG
+
@@@FFDDDHHHHGIIIIGGGGDEFGFDFHIIGIGGIEFGIFFHIGIIHIIIIGHIDCCHHIIIEHEEEEHFFFFDDED5>>ACCCCCDCDCDDCCCDDBD@
@3B5
CTGGGAGGCCAGGTACACCATACCCGAGGCGATCTGACTGGCAATGTGGAGCATTTGGGAGAGCCCCAGCTCACCCTTGGCCTGGCGTGGCTGTCCATCC
+
@@@DDDD8DFD?A2AC:FGGHBGGIB)?8D6?FCBBBFFICFIEEECEF36?6;B@DD/=B?;(=?B@BB3:AABB23?3>>>?B<00999BB?@B@B:?
@3B6
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
@@@DFFFFHFHDDGBE:EBHIGIIBEH@GG<:D@BBHI@?FHGC@BGBH=@FC@=E@=;?CCCF.;BD;@@CEEECACC5>C??C@B>>:5;A@4:@CCE
@3B7
GACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFDDDDDDDDDDDDDEDDDDEDEDEDD
@3B8
GACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTT
+
;==DDADDFFDHDBBH>EHCGFFAGGI@4CCDDD<@:66@ABHFHIDC@C)7?;?CD;BC@BB@BB?B(8?<AAAACC<D>(4:>>>?B?B9B><<BABCC
@3B9
CGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTG
+
@@7D?1@1ADFFDF@FBCFAA<EFGBF;?B:916@BFDBFD<8CFECFAAFEFFCC@@A=>7?B:@D>B>@A;;;A;3,3/3>B5>?39?@1<<BB@.0?@
@3BA
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJJJHHIIIJJGHEGIGJIGJJJJJJJJDHGIDHII-=FGGIIJIJI5?EEHFEFFFFFDEDDDDDDDD?@BDCDDDDDDACDDDDDDD
@3BB
GCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGC
+
CCCFFFFFHHHHHJJJJJJJJJJFHIJJIJJJJJJJJJJJJJJJJHJJJJJJFHGIIIIJJJJJJJJJJ@EHHAEFF;@BBCDDDCDD8ACDDDDDDDDDD
@3BC
ATCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
<@<AD1ADFHDHFBFFH2AFB<FHGIIIEHIE)B@?F9DEEC>;DG;CHICEFB@GGGEFFEHE<?A<?;@ACAAC?@BBBC:>@CCC:>>3@AB9<@7<A
@3BD
ACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAAT
+
CCCFFFFFHHHHHIJJJJJJJHIJJJJJJJJJJIJJJJJJJJJJJJJJJJJBFIJJJJIJJJJJJJJHFFFDDCBDDDDDCDDDDDDDDDDDDDDDDDDDD
@3BE
TGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCC
+
?@@DDDF<ABFFHIJJJJGHGHGIEFIIIDFGGIIDBH>BEHHGHDGHHIJJB==)@FHGIJJFHHDADBDBDDDDDDDEDDDDDDCCCDDACDDCCDDDD
@3BF
CCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTG
+
CCCFFFFFHHHHFIIJHIGIJJJJJIJJJJJJJJJJJIIIIJJJJJJJIJJJJJJGHHHHHFFFFFDEEEEDCDDDDDDDDDDDD:ACCDEDDDDDDDDDD
@3BG
CTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTT
+
@@@DDDFFGHHBDEDFHGGGHIBGHIEHGEGGGFGHIGGEDHHGFHHGIGIIJIJIJBFGC@FFEHIIEIGHEEHHHHFDD=CD:@;>A>:@>>C:CCCCC
@3BH
GTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAAC
+
BBCFFDFFHHHHDGIJJJJJJJJJJIIIIJJJJJGGIJGIJJJJJFIIJJIJJJIIJJJIIIHHHHHHHFFFFFFFEEEEEEEDDDDDDDDDDDCDDBDED
@3BI
CTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATG
+
@CCFDEDEFDFHGIJJJIIIJJJJJJJJEIJIIIJFIGIIGJDHIJJIIJIGIIJGIHHHJGGHJHCHGGGHBHHIEGHIIJJIHEEHHHFED@DFEFEEC
@3BJ
CCTTGGTCGGGCTGAGGTTGTAGCACTCGGCCAGGAAGACCTTTCCAAAGGCTCCCTCACCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGC
+
@<@D=?=;FADFHBIGAEECEECCCHHGIIIDG?BBGGBHBEG=FDHDGHBG>DE;?CBDDECCE@CDABB?<BACCCBB9?8?A>AACCCCCCCDCC4:>
@3BK
GCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJHHIIIHIHIIIJJJJJIJJJHIJHHHEEFFFFEEEEEDDDDDDDDDCDDABBDDCDDDDDDDDDEDDDDD
@3BL
TGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGC
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJIJJIJJJIIJJJIJIJJIIIJIGJJIIIJJHHH?ECDFFFFCEEEEEDCCCBDCBDDDCDDDDACDDDEDDD
@3BM
GTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTG
+
CCCFFFFFHHHHHGJJJIJJJIJHHIJJJJJJJJIJIIJJJJJIJIIJJIIIJJJJIJJIJJJJJIIHHHFFFFFEEEEEEEDDDDDDDDDDCCCDDDDDD
@3BN
CACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCAC
+
CCCFFFFFHHHHHJJJJIIJIJJJJHIIJGJJHIJGIGIJGGJJJIGIHIJJJJJJIJJJJJJIJIJIHHJIGIHGJGIJHGHHHFFEDDEEEEEDDDDDD
@3BO
CTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJHHHHHHFFDDDEDDDDDDDCCDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3BP
GGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
??=BDD>;FDDAF@GFFHI>EHCEEGC@C@GGG<FGBD@G9BFCB@FB>F9F8B@CAD@;=@3=77;A??(.;;6>@C>;;;3>CCD>@=?859@9>34>
@3BQ
GGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
@@@DFFFDHHHHGIJGIJGGIJIJIGGHIIJJFIJGHJJJJJIIGHJIIJGFGECGHGIJJJIIJIJJHHGGGGBDFFFCDCDDCCDDDEDDDDDDDCDCD
@3BR
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJIJJJJJHHHHHHFFFEEEEDEDDDDD;?B@DDDDCDDDDDDDDDDDDDD
@3BS
CGACCGAACAAATAAAAACCTCGAAAATTGCCTGATGAAAAATAAAATAACCAGTGGCTTTTAATGGCTTCTCCTGGTTATCAGTGCTACAAAAGACAAA
+
@?@;?<:8DFDFFIIIII?;F??8BGEFEEGFFFCEDFFE@FFF>C@CC@777@AAEFFBDDB7;6(;@ABABBB;;553>B>(;(:;>>A@B??8999?
@3BT
CTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCT
+
@CCFFDFFHHHHHJIIGGIIJJIJJJJIJIIGIJJIIHHIJJJJJJJJJGGGHGJJJIJIGIJIIJIGIIIGIJJIHFFHHHGFFFFFFEEDECDDDDCDD
@3BU
CCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGT
+
CCCFFFFFHGHHHJJJJIJJJJIJJJJJJJJJJJJJJJIIJJJJJJJJIFHIIJJJJJIJJJJHHFFFDDEDBBD?BCDDDDDDDDDDDDDDDDDDDDDD?
@3BV
GGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGG
+
@@@FFFDDFDHHGIIFHIG?CF@DGG?FGIIGIIIIIIIIIIIIEGHIFCGGIGEEEEFFFFFFEEEEEECCCA@@CCCDCCCCCCCCB>B@B?@@CCCC@
@3BW
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTT
+
CCCFFFFFGHHFHHIJGIIIIJIJIJIIEHHIFHIJBGHIHIJIHIJCHIJICHJJJJHHHHFFFFFDCBBDDDDDDDDBCCDCDDDDDDBDDDDCDEDEE
@3BX
CCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTG
+
CCCFFFFFHHHHHJCFFHIJJJJJJJJJJIJIIJIJJJJJJIIJJJJJJJJJJIJJJJJJJJJJHHHHFFFDDDDDEDDBDDD<AADDEEDDDDDDDDD@D
@3BY
CTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGG
+
@=?D;DDDCF<F:<<AE<F@4CAADDEHIIICBDEBHHA??GBCEDEC@FDFDBBDDFF@BDDEFIIIEIBFIGBFAF;DAEEADEE>ECEE@7@BD@?3@
@3BZ
CGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGGGACTGTAGCAGTGGTGG
+
@@<?D@DDDD;<DDGGGDFFCHHDDHHIEI@F<FHEFEDHI<BBB<D?9DH988C=8FHA;D==C=@EEHF1;??A;>=B@BB/8802<CDCA@C:>A+<<
@3C0
CAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTC
+
@@@DDDD==2CFFBEBBC<EHECDFBFEDGEEFFIFGAB?D?DDFFFEGDGI9<GFDFGIICFGFEFFFGGF@DCEFBDCB@??<???BBBBBBBB@@ABB
@3C1
ATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGG
+
@<@DDDADD<AD?EBD@DGD>I::FDGHIGI@?<@@DGHAADHII@GD4B@GIG4FG:4)B;ACHGHCECHFH9?>C?D76>>@@;@3;;C;;ACA@C>?B
@3C2
CTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATT
+
CCCFFEFFHHHHHJJJJJIIJJJJJJIJIJJJJJGJIJJJHIIJJJJJJJJJJIGHIHIIJJJJEHHGIJJJEHGIGIIJIDHIJEHHHHHFFFFFFFEEE
@3C3
GAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCT
+
BCCFFFFFHHGHHIJJGIJJGGIJJJIEHIIJJFFIJJIJJJIIIIIGIJI@FGFIIJJBGIGJJIJJJIIGHJJJJFEH7?ECFF@AEEEEEEDDDDCDD
@3C4
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGGACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATC
+
CCCFFFFFHHHHHJJJJJJJJJHHHGHIJJIJJJJJJJJJJIJJIIIJJJJIHHHHFFFFFFEEEDEEDBDDDDEEEEDDDDDDCDDDDCDDDDBDDDDDD
@3C5
GCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCT
+
8?@FDFFFGFFDDEHBHHJGJIIIGGHI@GDEF>FGGA@F>F@FGGIFFFDFHIJGCDFDEBDGGCHG>GEEGH7CA=E)7AH@CEFEBBBC@CCCCCDAA
@3C6
CTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCA
+
@@@DDADDH?FCFHIIGIHGI@H<@C@BFFHGIIIIIDFGEGEA<?DGCBB?DG?D4BFCGHICGHICGCDH@CGEDG=CAHHFH@;?@DDD@A;@AC
@3C7
ACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTT
+
B@@FFFFFFFFHHJJIJIIJJJIFIGIJIJJJIJJJJGIJJJJJIDHHIIJJJJIIJJIIIIGJJJJJJIIJJIIIIIJJIGHHHHEFFFFFFEEEEEEEE
@3C8
GGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATAT
+
CCCFFFFFGHHHG<CCFHIJJJJJJGIDHHIJIJIGIJIIJIJJJIB9??FGIGJJGIJJJIGIIIJHHHHADFFFEEEE??B?BDDDDCCDDDDCDCDE
@3C9
ATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAAC
+
CCCFFFFFHHHHHJJJJIGIHIJIIJJIJJJIJJJFHIJIIJIFHHIGIIJJJJEGIJIEHHGHHFFFFDEEEEDB?BDDCDDDDDDDDDDDDDDDDDDDD
@3CA
GTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJFHIJJIJJJJJIIJJJJJJJJJJHHHHGHFFFEDDD=@D8@D;BDDDDCDCDDDCDD4
@3CB
TGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACT
+
:???:=AD>DDD8C<+AEE4AAE?CFDC<+*:::?<??DBDDDB9B@BCCBDE*77-<82@CDCCCCCACC;?7777@=:>3>AA>A>>>A;5;:>ABA35
@3CC
GCTCTATGAACTCCTTCAGCATATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGG
+
?;;BDDD?FFAF?GE@EH?<?HHGHIHGGICFCHIGDADAFHI@A?FHHHGGIGHGFGIGGIIIIIHIFHFHEEEECCCCCCCCDC@CCBBBBBBB>>&59
@3CD
CTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAACATCAGCCAAAGCCGCCTTTAGCACAGTGATTTCAT
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJIHIJJGIJIJJJIIJHGHGHFFFFFEECEEDDDDDDDDDDDDDCCDEEEDEE
@3CE
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
CC@FFDEFHHHHFHIIJJIJIJJGJJGHCEHHIJJJJJJIIGHJIGIJHIIIIFGIIFGGIJEHJIEHFFFFFFDDEECDDDDDDD>ABBDDEDDCDDDD?
@3CF
ATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTTGCTGGGGTATGGCATATATCC
+
<??DDD8D=BADHIIEGHGEFG<3?:CF>HHIIIIGAFHIGAG>@C7;.7).=?EHE>>D@;;@C@;(;@C@CBBCCCA:>::@<55&:@??CCCCCC3:
@3CG
GCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTC
+
??;+ADDDDDDC:CEEBBCF>E>C3ABBDFIBB;E>FE>4CDD@D>DEDEEIID>DDDID>DAADDDDD;?9>>?6=?;AAAA><>>4:>(:881<<>A>
@3CH
TATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@<?=A?=BF+CFF;C1+2AA3<AC>@241?1:BD>CFGF<?DF6@CA;FFE).)7=76=A=;;.73>@A>66,5??>:;5>>>>?>:>>@+:A?0<>?(4
@3CI
CTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJGIIJJJJJJJJJFHJHIIJJJJJJJJJJJJJJJJJHHHHHHHFEFFFEEEE
@3CJ
CCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCG
+
@@@FDFFDHHFFGIIJJJJIGGIGGGIIIGIJGGHIJGIG>FGIIIJECE:BFBEHIIJIFIFEHHIIGCFHHGHD;7?@CACEACCCDDEDCCCDDDACB
@3CK
TCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCC
+
CCCDDFFFHHHGHIGIHBHIGIIJJIHJIJGI;DGHIJIJJGGIFGIIIJEGGGIJIJIJGGHIIJJHHHHFFFFCCCEEDDDDDBCDB?BDDDCDDB?CD
@3CL
GTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGG
+
CCCFFFFFHDDDFGBAGIGIIIHEHFFHIGHIEGIIIIIGIIIIIIIIIIGHGGDHHIIIGIIIIIGHIIIIGHECHCHFFFFDED@CEEDDCCDD@CDEC
@3CM
GCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTTTCTCC
+
@@@DDDFFFBDFFHGGIJIJJJEHEH@HIIGBHG>HECHGGFGEF9DG@F@BFGHCDHGGHJHGHGECCFFBCCB=@=ACC?C885>>ADACB><BCA:A
@3CN
TGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCT
+
@@@FFFFFHGHHFHIJJJJJJJJJJJJJIHIIIJIJJJJJJJJJJHHHHHHFFF;ACEFFEFEEDDDDDDDDDDDDDDDDEDDDDDCDDDDDDDDDDDCDC
@3CO
TAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGG
+
CCCFFFFFAFHHHIJJJJJFGHIIHIJJIJJJJJJJGJJJIDGGIJIGIJII@FHIJJJHHHFFFFFDEEDEEEDDDDDDDDDFDDDEEDCDDDDDDDDDD
@3CP
GGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJFHIIJIJJJJJJJJJJJIJJHHHFFDCEEEEDDDDDDDDDDDDDDDCCDCBDDDDDDDDDDDDDED
@3CQ
GTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACC
+
@@@ADBBDHFBCFIIIFHHFGGIB<FA?FEGIG?6?DF?@G@;FHGIDHIC<??@BADFEAE@C>>?>BBDDDDD@C>BBB9BBDDDD@<BBB<<BBBDD
@3CR
GGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGC
+
@@@@DDAAD?F=FHIECG@FGHBHECH:D??:BDHHIIGBGGA<?BFHIIGIIGGII>ACAEECA@?CC?B@8ACBBBB<AC3>@CBCB@ACCCCC?CCCB
@3CS
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFFFFFHHHHGIJIJJJJJIIJJIGHJJIJJJIIJJJJJJJIIHJFHIJJJJJJJJJJJIIJJJHHGFFFFFFEEEEDEDD@BBCDCDDDACDDDCCD@
@3CT
CCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGG
+
CCCFFFFFHHDHHJIJJJJJJJJJJJJJJJJJJHHGIJJJJJJJJJJHHIJJJJJJJJJJJIJJJJJJJJJHHFFDCECFEEDDDDDDDDDDDCDDDDDDD
@3CU
CGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACC
+
@@@ADADDFHHFFGEAFAHEGIGHCG@F@D?<FGHH<FBFCGHGGIIEAGCCHHF>BDE<CCECA>;A86:==9:@C>CC?A>2@:@CA@B<AACC@:AB@
@3CV
CAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGGGT
+
@CCFFDDDFFHHHIJJIIIIJJJJJJIIJGJIIDIIIGHIGIIJEECHIGCHEEHBDDFFC<>BCCDDDDDBB8?BBDBBDD:A>@CDCCCCCCCCCDD>)
@3CW
CTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGT
+
@C@DBBDDDHHHHGHIJIGEGEFED@CBG>DEGIIIEAB?DBE@0?FGDIHHJJG@FEAGHIJJJIHHBC;?C;;@C;AEA>CAAAC>CBCA>ACDCCDC>
@3CX
GGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCA
+
BCCFDFFFHGHHHJJJJIJJJJJJJJJJHGJJJIIIJHJJIJJJJIJIIIGJJIIIIJHHFFFEEDEDDBDBDDDDDDDDDDDEEDDDDCDDBDBBDDBB
@3CY
GCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTTTCTCCAGGACCCAGGGAAATGTTGCCCCTGGAGCCCAGTCCCTGGCAGCCTT
+
@@@DDABDBAHHH@EBAGGGICGIIEEGGIBFGBF?GBFFHIIIIIGADGFHGEGG3@FEGEHEEHEBC:AD@ACC=B@ABA?B<<ACCC>CCBBC8?8CC
@3CZ
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@<DDDDDFBBD?ACEFGF<AG?FCHHHFCHEEFFI@?FFIIICGEIEG@F?9BFEEFEEDC@@EEEEEFEADDCBB&53>AA>?:?A:@BBD>@AB@>A@
@3D0
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGTTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@@@?BBBBFF8AA3A?CBG:ACBA<AF@>E3CEG>C9CE*1:C?)??)08DFCE@8==@@F))8)7=.=?ACEE)=@))77?((6>ACA5>;@38'589?:
@3D1
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJJJHHJJJJJJJJJJJJGGIJJJJJJJJJJJJJJJJJJJIIJJJJIGHHIHHHHHFFFFFFEEACEDCDDD8A@DDDDDDDD?BD
@3D2
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
??<BD?@DDFHCFHB<CFDEA?AF@EEGIG@FEGBB>@FEG>DBB>FAB>FF>>FHIIE@HE7??B:?>D@CCC:6@A3@:ACA55>CC(:;58@<BB(5<
@3D3
GGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTC
+
CCCFFFFFHHHHHJFHIJJJJJJGIIJJIDEHIIIJJJIJIJJIJIJJIJJJIJJIJJJJJJJJHFDCECDDDCCCCCDDCDDDDDDDDDDDCDDDDDDD>
@3D4
GGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTG
+
CCCFFFFFHHGFHGIIGHFHIIIJJJHIJJJJJJJJJJJJJIJGFDDDEDEEDDCDDDEDDDD@DDDDDDDDEDDEDACDDDDDDDDDBDDBCDDD@DD<B
@3D5
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTT
+
CCCFFDFFGHHHHJJIJIIJIGHJIJGHIIIIIJJJIJJJJJJIJJIJJHFFDEEEEEDDDDDDACA?BABDDDEEEDDDDDDD?CB@DDDDDDDDDDDDD
@3D6
TATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTG
+
C@@FFFFFHHFHDIIGIGIIJHHGHHEGHIIIIJJIJIGIIJIBG<DHIHIEDGGIJJHIIHGEGIFDGHE=?ADFDCDDFEECEEDCCCD;A@>AC<@@C
@3D7
CACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCT
+
CCCFFFFFHHHGHJJIJJIJIJJJJJJJJJJJJJJHIIJIJJJJJJJJJJJJJJJJJJJIIJJJIJJJJFHIIHIIIIIJIIIHGHHHHHFFFFFFEEECE
@3D8
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
CCCFFFFFHHHHHJJHIJJJJJJJJJJJJJJIJJIIJIIJJJJJJJIJJJJJJJJJIEHIJHHH<ACDDCDDDDDDDDDDDDDDDDDDDDDDDDBDDDDDD
@3D9
GATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCC
+
@@@DDDDDFFF?FGFHC<@HH@FBB?HEE<CFFEHECCGHE@GGH=FDCFH?AFA==;@).=AE;7?A@CDCECCC>CCD;A@CC>?5<?:ACCCAC<?C@
@3DA
AGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACC
+
@C@DFFDDFHDDHFEEHIGIGHBHFGGIIIIIJJGIIIJ<FBFHEGIGGA@GGCGHGJGH@G@CHIGHHHHFAD;?CEDECCEDDDBABB>>CDDFCDDD
@3DB
CTCGGAGAGCCTGGACTGTTTAAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCT
+
<@@DD>D@BFDAAB:A@DEFBBHCHIEHE??FA?099BF@GHE335;;A:ACBCA>@?+8?CAC:>CCB?99@58?CC3@>@C><(>CBC@@@000<AAC:
@3DC
TCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGG
+
@?<DDDDD?FHBDBGBGGC<AHHI?HAC?HEDA?FHGIDHBHI@DB??DGGGEA@FGIGII=FCBB@;=;CD=@6??A?9=6;ACCC;>ACB>CCBBBB@
@3DD
CGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTGGGATCCAGTTTGGGGGGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACC
+
?<?DD)A:?4D<?::AA<333<AB<F3C329C3*):*)1:)0)9B)9BBD>B7''')0&)0(:>>(::><88&(+((4(:(+++9A:>49AAA:+91(4:
@3DE
GTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTG
+
@@@DFFFFHHGHHJIJJJJJIJJJJJJJJJJHGGIIIJJJJJJJJIGGJGHIIGIJGIIJJJGHGHHHFFFFFFEEDDBDDDDDDDDDDDDDCDDDDDDDD
@3DF
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
CCCFFFFFHHHGHJGIIJJJGCGHIJJJJIJGGHGGHHJIEGIJGIGIIJJJIFHIJBDHHHGECDFFFDDDDDDDCDDDDDDDDCDDCCDDCDDDDDDD
@3DG
GTCTCCATGCTTCATGTATTCAAAGACCATGATGAGGGGGTCCCCATCGCCGCACACTCCATAGAACTTGACAATGTGCTCATGCTGCAGGTTGGTGAGC
+
CC@FDDFFHDFH>GIIIGIIJGIJJJIJJGGGFEHIIGEH@FGGHGIDIDGIDDFCEEECCCDDDDDDDDDDDCDDACCDCCCDDDD:?ABACCB<BCDD
@3DH
ATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGAT
+
CCCFFFFFHHHDHJJJJJJGCGHGIGIJJJJJJJJJJGIIIJJJ@FIEGDHIIHGGEHHFFFFFFDEDEEDDDDBCDDDDDDDDDDDBDDDDDEDDDDDAC
@3DI
GGAGAAGCGGCAGCTCAGCTTGGACATCAACAAGCTCCCCGGCGAGAAGCTGGGCCGCGTGGTGCACATCATCCAGTCACGGGAGCCCTCCCTGAAGAATT
+
@@@FFFDDHHGHHJIIIJJJJJIIIJGJJJIJIGGIGGIGIJGEFDDDDDDDDDDDDDD@DDB@CCDDDDDCCDDDCDDDDDDDD@BDCDDDCDDC@CCCD
@3DJ
CGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATC
+
C@@FFFFFHHHHHJIIIBHGIIIJJJGIJJJJJJJIIIIJJJJJJIIGGHHGFFFFFFCDDDDDDDDDCBBBDDCBDDDDDDDDDDDCA@BDDDDDDDDDD
@3DK
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCT
+
CCCFFFFFHHHHHJJJJJGIJJJJJJJJHJJJJJJJJJJIJJJIJHIJJJJ
@3DL
CTGGGAGGAGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATG
+
@@@DDDDD+AD?FGHBHAHGIIIIEGIIGGEGECGHIGDBGGHB?GGCHGHGHCHGHFGGEGA@A7?ACE??DCBCCACECDCDADCCDDCAADCCC@ACC
@3DM
GGATGAACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGT
+
@@@ADA>BD?FFAGBHIG=9BBEFE>6??B4BBFEFEHGHDGBHFDDC@A>6@A@@55?88<CCCDACACA@@@AACDCCBBB??@CC@:>94<?3:CCC3
@3DN
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
???@:=ABD:C:DE=EEB4?3A?61?ECEBDBDEFEDDEEDDEEDDADD??BBD;DBA61@DADDDDA<=;??94,(;(-;;A;>;;>A=59=:>>AAAA:
@3DO
CGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTT
+
CCCFFFFFGHHHHGHIJJJJJJJJHHIJJJJJJJJJJJJJHIJJIJJJJJJJJJJIIJJJJJJJJJJHHHHFFFEDDEEDDDDDDDDDDDDDDDDDCDDAB
@3DP
GCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGC
+
C@@FFFFFGHHHHJJJJJJIJGGFHJGJJIIJJJJJJJJJJIJJJHGIIIJJGHIIHGHIJJJJIJIII@CHHAHFF;>ADDDDBCDD?BDDDCCDDDDDB
@3DQ
CTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACAC
+
CCCFFFFFFHGHHGJJIJJGIIJBFHIFHJBFHIIJJJJJJJJJIIJIGHHHFFEFFDDBDDDFECDDEDCDCEDDDDCCDDDDEDDDDDDDAACDD@BDD
@3DR
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
B@BFFFFFHHHHHJJJJJFHIJIIJJJJJFHJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDDDDDBDDDDDDD
@3DS
CCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACG
+
@@@DDDDDBDFFBEEGHIGG@BEAACEHGHGGB<?EGDCCGGBAGIIID?@HAG>=FECHHGCEEC7?A?AEC>B@>?@>?@ACCB>>C;:C@CCCB<@B@
@3DT
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCT
+
@@@FFFFFHFHFDIGJIJCCHIIIIIJIJJCGIIEIIJHJJJJGIGIIIIHIIHHBFIGIJIHIIJJACEH>EECE;@??>D@CEEECCCCADDDDABBC>
@3DU
CTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCTGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCT
+
B@CFADDDFFHHHJIIIIJIIFIIIJJJGIHHJJJJJJJIGGIIIIJJ)=FHEEHHFFFDBB@BDDDAC@DDDCDDDDDDDDDDDDBDBDDDDDDD<BB>>
@3DV
CAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGT
+
1?@ADB4BDBFADAFB?GEGEAFD@BG;?B@BFFE69BDFBC9D@@FBD>D4@@CEEEFE?BD@?ACACDBDBBBBA?AABBBBB:@AABB@BB@??<@@(
@3DW
TGCTCATTTCAAACAGGAGCCAATGGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGCGTTCTTAAGGTGTCTCAGGTTCTCCGGGA
+
?8??==A=DD?AA<AE9<C;FE@?222A9<::???3:<@C?:D0*?9B9DEIIE<??=B=.>88=7=@D(-=A1?;;?;7..>;;.6>;--5;A>22,0
@3DX
GTCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIIJJJJJJJFHIJJJIJJJJJJJJJJHHHFFFFFFEEEEDDDDDDDDDDDDDDEEFEED
@3DY
GGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTT
+
@<@FFFFFHHDHHGHAC@GBHIIIJJJJJIJIJJJEIJJJJGHIIJIJJGHHHIJJIJICHGHHB<CDEFDEECCCCCDD?5>CDDDDDC@CDDEECDDDD
@3DZ
TTGTGTTTCAACAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTTCATTCCTTCCGATGTTGACAACTATGATGACATCAGA
+
?@?AB:BDFFHD>DFEGGCBCGHHIHDHIIIIII?FGHBHIIGBHFAFBGHAHEEFHH>@E>BDEC@ADCCC@@BBB?CAC@CCBC>@>ADCDCCCCCCC
@3E0
ATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTAT
+
BB@DFFFFHHHCFHGJJJJJAFHIHGIIJJJJJIJIIIIIGIIIJJIJIEHIJIJJIIGJGIIIGCEHHHHBDFFFFFECACEECC=CCCAA>AB?BDBCC
@3E1
TTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTG
+
?@@FFDFFHHGHHJJJGHIJHIIJJJJJIJJJJJGJJIIJJJJJJHIJJJJJJIJJJJIHHFDDDDDDDDDEEDCCDDEDECDDDDDDDDD
@3E2
CCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCATCGAATTTTTCTGGGACAACACAGGTGT
+
CCCFFFFFHGHHHIJJJJJJJJJJJJJJFIJJGIJJJJJJJJJJJJJIGIIIIJHHHHHFFFFFFEECEDFDEEDDDDDDDDDDDCDDDDDDDDDDDDCDD
@3E3
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
C@CDDDDFHHGGHIGIJJFIIJIDHIJIJFCFDGCFFG<DHHIICHGGGGIIIJIIGEEDFFCEEEE<ACDDCCACDDDDCE@BDDCCC:ACCCBDDBDC?
@3E4
GCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAAT
+
@CCFFD?DHDFHDHG@FHIIIGIIIIIIIIIHGIIIIIIGHIIIIIIIHGIGHIIHGHIDGHHGIIIIIIIHIIGHIGIEIIIGHHCHHFDBCEFFEEECC
@3E5
CAGCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCT
+
CCCFFFFFHHHHHIJFGIJIJJJJIJIJJIIIJJJIIJIJIGIJJGIJJJJJJIGIGIIIJIJJIEHGFGGCHHHIJJFJJHHHHHGEADEFFFFEEEEEE
@3E6
CCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGG
+
CCCFFFFFHHHHHIIJJJJJJJJJJJJJHIJJJJJJJIJJJJJJJJJJJJJJJJHHHHHFFFFFFEEEEEEDEDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3E7
CTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCTCAGACATGTCTCACAGCGAGAGAGATCAGGAAGTTCTC
+
CCCFFFFFHHHHHJIJGHIIIJJJJJJIJJJIIIJJJIJIIJIIIIGIHJJJJEHIJJJIHIJIJIIIJIIIHEHHHHHFFDDDDDDDDDDDDDDDCDEED
@3E8
ACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCT
+
@@CFFEFFHHHGHJJJJJIJJJJJJJJIJGGGHIJIJJJJJIJDDDDDDDDDD9AC>CDDEDDCDCCCB?BBDDDACD>CDDDDDDCCDDDEDDDDDDDDD
@3E9
GTCCATGGGGTAGCTGCTATCTGGTATGGACTACGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCAT
+
CCCFFFFFHHDFHIJJJJJJIJJJHIJJJJJJJJJJJJJGIJJJJJCHHIIIJJJJJHHHHFDDDDDDDCCDDDD?@@CDEDDCDDCDCDDDCDDCDDDDE
@3EA
CCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGAT
+
CCCFFFFFGHGGHGHIHHHIGIGGIIIJCFHGJJJIGIIJJJIIJJJJJJJIJJIJGIIJJGGGGIIIHGHGHEEEDDDDDD?CDDBDDD;CBDDDDDBDB
@3EB
GGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCC
+
CCCFFFFFHHHHHJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJDFIFHIBHIHHHHHHFFFDEF;ACCDDDEEDDDCDDDDDDDDDDDDDDD
@3EC
CTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAG
+
@@@DDFDF?HHFHGGGCEHIIGF>HGGGEHGGDBFGHCDGHGBIJICGGIDGIEC=);?;=EC?BCB;;@CCECCBB?ABB?<AACC>@@CCC:>>AC?
@3ED
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGATGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
C@@FFFFFGHHGHIIGGIIIIGHHGGGIIHIIJGIIIJ@AFHGHFG7=FGCGCHEHI;@EHEEHCDEFFFDECCEEDDD>@BDDDDDCCB>>ACDDBDDBD
@3EE
CTCCTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCA
+
CC@FFFFFHHHHGJJJJJIHJJJJJJJJJJJJJJJIGJIJGIIJFHHGIIIIJJJJJJHHHBDFEEEC>?BCCACDFCFEEDDDDDDCCDDDDDDDDDDD
@3EF
CGGTTTTCCAGGCATTTCACATATTCTTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTT
+
@CCDFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJIJJJJJJIJJJJJJJJIHIJJIIGHHHHHFFFFFFFEEEEEEEDE
@3EG
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJHIIJJJJIJJJJJJIJJJJJJJJJJJJJJJJJIJJHHFEFEEEEECEDDDCCDDDDDDDDDDDDDDDDD
@3EH
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGT
+
@@CFFFFFHHFHGIICGIHEHGHIJIIJHGFIGIEIDHIIDGIIII=CHGHGGIJJJJIHDHHHHHHFFB;@@C;@AADDDBCCD:ACCCC@CCD9@>ACE
@3EI
GGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTC
+
@@?BDFDFHDHFHIGGIEHCHGHHGEEEHE<ACGGEHGDHCGIFFDIIIGIGDHGBFHIIIIGB4=FGHHCEDDHHIFH>AE>@DDFFE@CCC>>C6>C>
@3EJ
CTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGT
+
CCCFFFDDHFHFFHIJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJIIJJJJJJJIHHHHHHFFFFFFEEEEEDDDCCDADDDDDDCDDDDDCDDD9@DDB
@3EK
ATTAAGAATACATTTTTGGTATATTAATCAAGTGTGTCAGTTTCTTTATGTTATAACATGTCTGAGTGTCCTAATTAAAATCTATTAAACTAACCTCTTC
+
CCCFFFFFHHHHHJJJJJJFHIJJJJJJJJJ+CGIIIIIJIIJJJJJJJJJJJJJJJJJJJJJJJJGIHIIJJJJJJJJJJJJGIHHHHHHHFEFFFEEE
@3EL
GTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGG
+
CCCFFBDDHHFFHJGIJJGGIIIJJEIJJIIJIIFIJIIIJGGJGIEIIIIIJJGIJJJIJJJJJJHHHGFFDFDDEDAC@CDFDDDDDCDDDDCDDCDDD
@3EM
CAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGT
+
CCCFFFFFHHHHHIJJJJJHIIJJJJJJJJJJJJIJBFHCFHIIJJJJJJJJJJJJJHHHHFFFFDEEEDDDDDDDDDEDDDEDDDEDDDDDDDDDDDDDD
@3EN
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGGAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
@;?DDB?D?DFB8A<EGIIBAFH@H>++22C+C;9C):C))00?F<090BFB0@/@4'.?EDDD7.(=65;;?(,(::5,>A(,(:4((++>:9@::>:4
@3EO
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGC
+
CCCFFFFFDHDHFGHGHGGIIJIIGIE@GFFHGIGG?@<GHADGGHIGADHGGCHEHEHHHEDEFDCD?BCDDACCCCDDCDDBDCCCD@BCDDCCDCDDD
@3EP
CAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCT
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJIHHHH?CDFFFFEEEEEEEEDEDDDDDDDD
@3EQ
GGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGG
+
@@@DD8AD?F?H>EAGHIGCHIIGIIICAD?FGIIAHEGCEEHCHIIE=CDHG<E?AC>ADB@DCE>C@ACBB?=<ACCCBB5<>@CCBCCBCC<<BB>>B
@3ER
CATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATGTTGAACAGATTCCTCCATCATCATAATGGCTTGGATG
+
CCCFFFFFHHGHGJJIGHGJJEHIIIJJJJIIGIGIIIIGHICHHHJJIJIIJIIIGIJIGGIIIIGG@GIIFAEC?CEH@DDDCEACCCECCDCBBDC>C
@3ES
CTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACC
+
C@@FFDFFHHHGFIIJIGGHHIJIIGEIGGIIIIGGGIIGGIIIJJJIEGJIIIIIJJIHGHIJJIIGCEHHHHHFFFF@AEEDAACDCEDDBBBBDDD
@3ET
TATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTT
+
C@CFFFFDHGHDHIJJJIJJJJJJJJJJJJJJIJJJIJJJJIJJJIIJJJJIIJJJJJJJIIJJGJJGHHFFFCDDDCDDDDDDDDDDDDDDDCDDEDDDD
@3EU
CCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAG
+
@@@DDAADFHHHHJDEEHEHHIIGEFHIFEHDGHIJJIGGIGIIJIIIGJIJIJJJJJJCHIIJJJCGIHGHFEDBBAC=CDDDEDCCDDDDBD>BAC
@3EV
CTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTT
+
@CCFFFFFHHHHFJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJIJJJJJJJJJJIJJJJJJJHHHHGHFFFFFFFEEEEEEEECACDDEEDDDCDDED
@3EW
GTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATT
+
@?@BDBBBDBHAFGGIHCGD@FG@FDCGEIIIHBFHIG@HI@A899BCCCCAC:?:<A5<(:?5:5>C:>CCCCDCCCC@CAACB@?C?B@?CCC((::A
@3EX
TCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTT
+
CCCFFFEFHHHHHIIJJJJJJJJJJJJJIHIJJJJIJJJJJJJJHIIIIJJJIJJ@EFDEFFEDEDDDDDDDDDCCCCDDDDDDD@BDDDDCCDDDDDDDC
@3EY
GCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGAT
+
CCCFFFFFHHHHHIIJJJJJJJJFHIJJJJIIJHIIJJJJGHJJJJJJIJJHFDDDEEDDDDDDEEEDD>CDDBDDD?BDDDDCCDDDDDDDEDDDDDDDD
@3EZ
GTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTG
+
CCCFFFFFGFHHHIIJJJJJJJJJJJHJIJJJJJIJJIJIIJJJJJJJJJJJJFHHIIJIIJIJIIIJIIIGGCGAHHH?EEHHHFDFFEFFEECEE
@3F0
CAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTC
+
1:;?D:+BDD?B<<:A;2<8CEAF<9:EDEE<3?D<?D<*:B**0?B3DD*/6*)/.)8/=ACAA3@A@C))=5;@737)7=(,('8='3&((+422((+(
@3F1
TGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCT
+
BC@FFFFFHHHHHJJJIJJJJJCHHIJJJJJJJGHIJJJJJJJJJJJJJJIJJJJIIJJJJJJJJJJJJJJIJJJJJJJJJJJHHHHHHFFFFFFEEDEEE
@3F2
CTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGAC
+
@@CFFEFFHHGGGIIIGJJGEHIIIDGGFHIIIIGDGIJIIJJGIIIJJJJJJIIFHHDBDDDDDDDEDDCCCDCDDDDD9BBDDDCDDEDDDDCDDCDCD
@3F3
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFDDHHHGHJIJJGIJJIIJJJIIJJJGJJIJJJJJJJJJJIJIJIFJJJIIGIFFHGHFFF9?@;CDDDDCDDDDDDDDDDDDDDDDDDDB>BBDD
@3F4
CCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCT
+
@@?DFDFDHAHHHJHGGHEIGFHHGH?CDEHGIIBEHIGGCHIDDAEECHIGDGIGIIAD9?FHIIIGHCEGHHIIIJDCECCBEDFFFFECEEEEE>@C@
@3F5
GGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGAGGGCAGTTGGAGTAGTATAACC
+
BBCDDFFFGFHHHJJIJJJJJHIJHHJGHJJJJJJJJJJJJJGIGIIJJJJJJJJJJJJJJJJHHHFFFFFEEEEEDBDDDDDDCDDDDD@CDCDEEEDD
@3F6
TATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGC
+
@?@DFFFFHFHHHIGBHGGGIGIIIIIIEIHIGHGBHIGEGEHDGHBGIIIGGGIIHEFHGFFFFFFDEDECEEDDDDAC>@CCC>A=BDDBBC@>@CAB
@3F7
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
CCCFFFFFHHHHHJJJJIIIJIIJJJJIJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFEEEEEEDDDDD;@BBDDDDDDDDDDDDDDDDDDD
@3F8
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCC
+
=??BDADA<CCDD<ECE?+ACEEE4FEF@AEFAEED?@DBBBBBD>>3BDDC99BBB=BA@-.;?)=>C;@D,6@>;.5(;;;55<?<5:>??<>>?A>>:
@3F9
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGT
+
@@@FDFFFHFBFDFGDEFEDHIIIBGDFHDGHEEGI?DEGIG<FCHGIJJGIACCEHHD@CEECCEECCDDDDCDDECCACDDDDDDDDEDDCDDDD@@B<
@3FA
CGCTGACGCCGGCGGGGGGCCCGTGTCTTGGAGGCTGCCTTCTTCGGAATGTACACTGGCTGCTGGCAAACCTCAGAGGCCAGGGGCCCTAGAGGATCA
+
CCCFFFFFHHHHHJJIDDDDDDDBBABCDCDDDDDDBDDDDCDDCBD@DDDCDDCDDDDBCBBCCDBDDDBDCCCACCDBB<ABDDBDDBCCDCDBCDD
@3FB
CTTTTATACCCACCCCAACAGTCTAACTCTAAAGAGGATAAAGCCAATGACTTTCCTCACAAGAGCTCACGACTAACGTCGCTTTGCTATCAAAATCTGT
+
<@@DDBD:DBC<A@@FFG;:A<<<CBCEGCFGBG4?88:?BD9BBB0/BF4?88=8=@FEA==@==7..==-,=<>@;@533=9<5>>@>A>:A:4:4>A
@3FC
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGC
+
CCCFFFFDDDDDDDDCD8?CDDDDDDDDD@CDDDDDBDDDDDDEDDDCCC9@CDDEDDDDDD@@BCCDDACDCC>CD@AC4>CCCDDDDDDCBBBA@CCCD
@3FD
GGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGC
+
@@@DFFFFHHHHHIIJIJJJJHIJJJIGIGJHGIJGHJJJIIIBGIJIGIIJJIJGHGHHHCFDFCDBDDDDDAAB?ACBD@BCDDDDDDD9<ADDDDDDD
@3FE
CTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATC
+
@@@DA=BDHBDB?DH?FGGEIHIGHIFHFHEHDCBGHIIIC:DBHGGIIIIIG?FEBBFGIIGB<@@CG@DEE?AEEHE;=BCC<@CCCDFCC@@BBBC>
@3FF
CCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGC
+
@@@DDFDDFHADHGBEG@D@HGEHAFCHEB?B;BCCFGIEHIIIECHEAAC@<BEDCECCCDECC=ACCC?@A9??5<@+8@<CDBCDBBBB(220289@>
@3FG
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CC@FFFFFHHHFHJGGBGIJEGIHIHIIHGIGHIGJIIGIGGHHGHGGCDFHIIIJGII;CE?EHCDFFFEDCDDACCBDD;@BCDDDDDDD@CDDDDDDD
@3FH
CCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
@@@DDDDDHHDFHHGFGIIGGGAEHHIJ+@F@DGIGHHEFHBHDHGGIGHDEGIIJJI9AE=A;CDDA>;:?@DCCDDCDD@A>59BBBDCDDCCDCC@C
@3FI
GTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGC
+
CCCFFFFFHHHHHIJJJJJIJJJJJJJJJIJJJJJJJJJIJJJJJJJJIJJIJFHIJJIJJJIIJJJIJHHHHFFFFEEDEEEDDDDDDDCCDDFEDDDDD
@3FJ
GTGCGACCGAGCTCAGGGCCCAGGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGG
+
CCCFFFFFGHHGHJJJJJJIJJJIJJJJGIJJJJJJIJJIJJIIJJJJJJJJGHHH?EDFFFFFDDEDDDDDDDDCDDDDDDDBDDCDDCDDBBDDDCDDD
@3FK
GTCGTTTCTTCCTTCTGCCCGTGACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACC
+
;=?BDDDBDHABD@GBFAEDD@<A?FHBFHDC?FDGBFB@F?FGIIIIGIIIBA?C>776?5;9;???::::C9<:?<A3:A?8<B>7>:@@C?>8<>85?
@3FL
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGC
+
B@@FDFFBDDDDDDDDDDCDDDDEEDDCDCDCDBDDDDDDDDDEDDDDDDDDDDDEDDDDDD@BDDDDDDDDCDCDDDDCCAC>CCCDDCDDDDD9ACCDD
@3FM
CCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTG
+
CCCFFFFFHHHDHJI@FHFHIJIIIIIDGHIGJJIIJJIJJJJIJBFHIJJIJJHGGHGHFFFFFECDEEEEEDDDDCCDDDDDDDDBDDDCDDDDDCCCC
@3FN
TGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGT
+
CCCFFFFFHHHHHJJJJJJJJHHIJJJJJJJJJJJHHJJJJJJJJJJJJJJJJJJJJJJJJJJHEHHHHFFFFFEEEEEED?CDDCCDD8ABDDDDDDDD<
@3FO
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
===DDBDEHHHHGJIJJJJIJIGHIJJJIEHIJJJHJJJIIJIIJIJGFHHIIJJIJJJJJJJII@BHHIGGHEHHFFFFFFFEEE@CDDDDDDDDBB9@B
@3FP
CAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACC
+
@@@FFFFFHHHHHJGIJGJHDHHIEFDHGGGIIGIGIJJHHHIIJEEEEEEEEEB=CACC@CDBDDDD@CCCECDDDDCCDDD@C@BBBBD@ACCD
@3FQ
CTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTG
+
@@@DD8DDFFDHFEGEG@DEHAFHE;FHEFDGIDCHA=BDDC:8AAEHEEEBDEEECCCCACCDC>CCCBC?5?CCCAC@CCCCCCBBBBBBB?@BBB??
@3FR
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTCCAAAAAAAAACGAATGCAAGAACTTC
+
CCCFFFFFHHHHHHIJJJJJJJJJJJJJIJJIJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJIJJIJJJJJJIJHHHHHFDDDDDDDDDDDDDDDDDDDC
@3FS
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFFFHHHHHJJJHIJIJIJIJJJJDDDDDDDDDD8ACDDEEEDDDDACCDDDDDDDDDDDEDDDDDDACDDDDDDDDDD9<BDDDDDDACD:CCD
@3FT
GTCCGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
CCCFFFFFHHHGHGHIJJJJJJJJJJJJIJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJHHHHH;BCDDDDCDDDEDDDEEDDDDDDDDDDD
@3FU
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFFFFFFHHHGJIJJIIJIGHGIJJJJJJJJJGIJJJJHHIIIIJCFHIIIJIIJIJIJDHJJJHHHFFFFFFEEDDEEDD?BDDDCDDD>CCDDDDDB
@3FV
CTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTC
+
@@@BDBDADFFBD:BAAEHHE@BC?:A<HDEHIHGHIEDHDGFD??:?B?@BGBEBDBFHGDAFFCGIIB<=28CFGI@DH=;ED@DEEEE>>>>C@;;>C
@3FW
CTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATG
+
CCCFFFFFHGGHDIIIJIJGHIJJIBHJJJJEHHHIIIIIIJJJJJJIIJJIIIGBHGHIJIIIJIEHHJGIGAEHHFDFFAEEECACDDDDDDDDDDDD
@3FX
TGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCC
+
@CBFFFFFCFHHHJHIJJJJJJJIJJJJJJIJJJHFFFFEEEEEDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDD
@3FY
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJJJHJJJJJJIIHIIIIJIJJJJJJJIBGHJHIJJBGGIHIJJJJJCEHHHHFFFFFFDDDCDDDDDD@BDDDDDDDDD:ACDDDDDD
@3FZ
CTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATT
+
@CCFFFFFHHHGHJJGIJJJIJJJJJJIJJGJGHIJJGIJGIJIJJIJJJIJJJIGJJIJJIIJJEEGHIHEEHDFDDDDBBDDDDCDDDDEEDDDEEEEE
@3G0
GTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGGGGGCTTGTTTCTGGATCCGGGGACCTTGTGCAACTCCGAAGGAGGGATGGACTG
+
@@@D7DDA?=:D:C:E;G??BBE)C8?)1:CCDB:9BFDBFD@8B(7'050(7(+<A33((3(+8&08558@:3+(:>(:(4>290)&+8-&&++(((+2
@3G1
GCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHHGHHJJJJJIGHJJJIJJJHIIJIJJIIJJJFHIJJJ?DFHHIBDDEDEDDDDDDDDDDDDDBDDDD>CD@CD@CDCCDDDDEDDDDDDD
@3G2
GCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@CFFFFFHGGHHJJJJJIJIIIIJJ@FGFHGIGGIIGIIJJJIGIJJJJJIEHJHBHFFFFEECEECCDDDDDDDDDEEDDCDDCCDCCDDDDDDDDA
@3G3
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJEGIGIJJJJJJJJJJJJJIJJJIJJJJHHHFFFDEEEDDDDDDDDDDDDDDDEEFECDDDDDDDCDDDDDDD
@3G4
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@@@DDDDDHHBFHH@HIIIIIIIIIIIII>CGGGGGGDGHGBFFHIIGGHIIEBGHHGIIIIGIIIIIIIIIHHFACEDEE@ABAC@BC@C?BBCCCCCCC
@3G5
GCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGG
+
@@@FF=ADFFHHHAFEHHGIJJJICGHEHFHHIIIJJGIDIJJJJJ@AHIGGFIJJJHIHHHHGFFFCEEEED>@CDEEDDDDDCDDDDDDDEEDDDDDBD
@3G6
TTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACT
+
CCCFFFFFHHHHHIIIIIIIIGIJJIJJIIJJJIJGIJJHHIIJJJJJJJIIJJJGHIIJJIJIJJJIIGEHCHJJGGIJJJHHHGFFDD?CCCBCEEDDD
@3G7
GCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACAT
+
CCCFFFFFHHHHHJJJJJJJJJJJHJJIJJJIJJJJFHGGGJJJJJIJJJHIJIIIJGGIJJJJJIJJIJJIJJIIIHHHHHFFFDFEEEDEECCDDDDDC
@3G8
CCATTTTCCACCTTAACAGGTGAAAATTTAAATCCCAAATTAATCTGATTTGTGGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGT
+
CCCFFFFFHHHHHJJJJJIJHHIJJJJJJJJIJJJJJIJJJJJJJJJJIJJJJJIIJIHIIJJJGHGIIIJECGGGIIJEHGEHFFFFFFEEEEEEEEDDC
@3G9
CATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATG
+
CCCFFFFDHHHHHJJIIJHHIJJJEG@@AEGGHGGBCGCGGC?FFBFFHIGGAD>>EGBF@DDFF;@=@7@EAEE=CE>CFCDC?@A@CEAAACCDAA@AC
@3GA
CTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTG
+
CCCFFFFFHHGHDHIIJIIJJJIJGHIJJJGHGHGIJJJJIJGIHJJIGIIJJIIJIIJJIIIJHHGFFFFCEEEEDDDDDCCCBDDDDDDEDDDDDDDC
@3GB
GCTTCCAAGGCCATGAGTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTTCTTCTTGCTCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTTTTTC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJIJJJJJJHIBGGIGHIJJJIJJJJJJJJJJJJIHHHHHFFFFFFEEDDDDDDDDDDDEDDDDDDDDD
@3GC
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
CCCFFBDDHHHHFIIHGHGGIJJIIIGGFHCFGIGICGGEGIGGIJIIIIJIDGHGEGGFHIIJIHICHFFHDE@DBCCCACDB5>@BD@CDDBD?ACCDD
@3GD
GCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGC
+
@@@FFFADHHHHFHGIBEHHIHIBGEHHGIGIJJIGGIJIJHIJJJIIGHIFGDGHEIIIEHGHHBFEFCEEDDBDD8ACCDCCCDBDBDDDDDCCDDDD
@3GE
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
CCCFFFFFHHHHHJJJJJJJIIJJJJJJJJJJIIJJJJIIJIJJJJIJJJJJJDHIIJJHHHHHHFFFEFFDDEDDDDDEDDDCDDDEFDDDDDDDDDDDD
@3GF
CTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTG
+
C@@FFFDDFHDFBHIIGDHIGIIGCFHI@?HEHG?DGGICIGHDIJJIIEICG9@BG?BDFGEGB@FHEIIDHIGIDGIEEHG>CDEFFFFFEEECCECC;
@3GG
GTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTG
+
@@@FFEDDHHFFFIHDHGHCFHFBHGH@GEEGGICFHIIIIGHIIIGGIBGGIIIIICGIGGIE=@FHIIHIIHHHGHHBCDFFDEEE@CCCDD=@;;CA<
@3GH
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
CCCFFFFFHHHHHJJJHIJJJJJJJJJHIJIJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJHHHFFDFFEEEEEDDDDDDDACDDCDDD8CBDCD
@3GI
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
BCCFFFFFHHHHHIJJJJJJJIJJJJJJJDDDDDDDDDD>CCCDEEEDDDDCCDDBDDDDDBDDDEDDDDDDDDDDDDDDDCDDBDDDDDDCDDDDCCCB
@3GJ
CCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJJJJJJJJJIJJJJJJHHHHFFFFFDEEEEDDACDEEDDDDDDDDDDDBDD
@3GK
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
CCCFFFFFHHHHHJJJIJJJGIIIJJIIJGGIJJGHIJIJIJIJIJIGIJJIDGIJGIJJJHCEHHEFDFDACAECDDDDBBB?B>ACDCDDDEDEDDDDD
@3GL
CGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJIJJFGIHIIJJJJJJJIJJJJJJJJJJJJJJIHHHHHHFFFFFFEEEECEEEDDDDDDEDD
@3GM
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATAT
+
@@CDDDDB?FDHHII:CFEBFHEGHHGGIII@?B)?DGCDGHGGIFGEHGGHGIIGIIIFHHGE@EE;@@ACEECCB?CCCCCCC@@DCCCCCC@CCCDCC
@3GN
GGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTTAC
+
C@@FFFDEFHGHGEIJJIEGIHIGHFHIGIIIIIBHIHIJHGCHHGIIJIJGIGIIJJJJGIGIHHHHGHBECCDEDD;>BB@CDDDDDDDDDDDDDD3>C
@3GO
CTGGCAGCCTTCCTGATACTCAGTTACACACTTCTCAACTTGGAAGCTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCT
+
@;@D?AD1C:<FFI@BDFE4CBGIB<F<4+)1*:91*:)CF?*??3;FFFGI<4**0?<=8B=C3@CCF8@D@@3@(55;@D)7;=?@(;ABB(;@:55:3
@3GP
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@C?DFFFFHHHHHJGIIEHIDEHJJIJJJJJJJJJFHIJJJJJJJJJJJJIJIIJJJIJJIIJJJJCHHHHFDDDDDDCDDCD>CDCDEEEDDDDCDDD
@3GQ
TTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAA
+
CCCFFFFFHHHHHJJJJJIJJJJJIJIJJJJJJIJJJIIIIJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJHHFHHHHFFFFFEE
@3GR
GTCCTTTCCCAGGTGTGGGCTCTACAATAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAA
+
CCCFFFFFHHHHHEGHIJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJIIJJIJJJJJJJJJGHIJJJIHHJIJHHHHHHFFFFFFFEEEDDDDDDDDDD
@3GS
AGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHHGJJJJJJJJHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJCHIIIHEHFFFFFFFEEEEEECBD;CDDEEDDDDDDDDDCCDD
@3GT
CTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
CCCFFFFDHFFDBGHFHIJIIIIJJJIJJJJJJIIIIGIIIJJJJGIJJJ@HGIJJIIJIJJJJJJJHGHGHFFFEDEEECCDDDDDDDDDDDDDDDD
@3GU
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
B@@DFFFFHHGHHJJJJJIIGIIIIIIFICDEHEHDHHGHGIJJGHGCGIJFJIIIFHFDFBCEEDDCDDCCDDDDDCACCDDDDDDDDDDDA?BDDDCDB
@3GV
AGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@?@DDDDDFF;FFIFI>?CGACFHFEICAF@FGEFEDEFDCDFBGEFDFFFEEI8B@<FFE6@AEF>EE9;?;BBCCC;A@?;;??,:<BBAABABB+8@
@3GW
GGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCT
+
BC@FFFFFH@DHHGHIJJJJGHJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJHHHHHFFFFFFEECEEEDDDDEDDDDDDDDDDBDDDDDDDDDDDDDDDE
@3GX
TAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTT
+
=;@+4:ADDFFDDFBE9:CEFGE>EHA:<<AAFF4<ACCEBGEF9*?DFFIFC4?D<DD4B?DC:<?D<=F(=@@D=CEFAED;CA>C7AA7;?@)7@AB
@3GY
CGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGC
+
@CCFFFFDHFHFHIJIJGGGIIIIJJJJEIGJJIJ?DHHJFHHIJJJJIIHIJGIIJJHHHGHDFEFFEEEEEDDDDBDCDDDDEDDDDDDDDDDDDDDDD
@3GZ
GGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTA
+
@@=DDDFDHBHF?AFEIHEBFFHFHIICCEDG;FDD@GIGIIIIAF?DHGIGECF?GCEGA7CHCACHHDFEFFFC@CEEEDEC@?ACBBCCCBB<@<>>
@3H0
GCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCC
+
<;@D?;BBDF?DC@GBGF>B8E11??DDFI??9:99917D@F>F8).'45-7@)7.;((6?)(6;(6((;5(-5<5:A@5==99@ABB@74<5@955<32<
@3H1
TTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAA
+
CCCFFFFFHHHHHJJJJJJIGGIIJIJIJJJJJJJJJJJJJJIJIIJJJJJJIJJJJJJJJJJJJJJJJJJJJIIIJJJJIIFFHHFFFFFFFEEEEEE
@3H2
CTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGG
+
@@@BDDD?D??BFIIIACGHE3AEHGIECHFFGGGHIIHGIGDA:??>BHIIGHHII>F>GGCFEHG=CEEGHFHEHEDDC>7@CCCC?A@;CCC>CCCBB
@3H3
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTT
+
;<;;BDAA<A?3A+AA@ABHEF?F?FFHBF9<FFIDGBG?:BCA@G@GCD8DFF=FF8=B>EF/-5?>=>A@AAB(;==??;<?<@@3:??BBB(4>@?B@
@3H4
GCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFFHGGHJJIGIIIJJJJJJJJJJJJJIJJJJGGJJIIIJJJJHHIJIGIIJGIIICIIHG@CEEHFHCHFFFFFFCEEEEEDACDDBBDDD@
@3H5
CAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCT
+
CCCFFFFFHHFDHIIIIJJJ<CHGGIGIIJJGJJIIJJJFGIJJIGFHIIIJEHIJJJIIJIIJGGIIIJJIJJJIIIIHHGDDFFFFFEEDEECEDCDE
@3H6
GCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTG
+
@@@FFFFFHHHHGJJGIJIHIJJJJIJIJJJJJJJGHIIGEGIIJIJJJJJIHEHHHHFFFFFEDDDDDDDBDDDDDDDDDDDDCDDCDDCDDDDDDDDDC
@3H7
AGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTC
+
CCCFFFFFHHHHHGJ@FBHIJGIJJIIIIJFGGJGFGIIIIHHHHHFFFFFFFDDDD@CDEDDDDDDDDDCDDDDDBCDBDDDDDDDDDDCDDDDDDBDDD
@3H8
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
???DDDBD,AD?DCED;EEFDEB11AECC;?:DDE?BD?B9?D>3898;B3=CB;C@@;).77;CCAADDDDDD>B>6;(;>8,8=>A>AAA>3:4(+>(2
@3H9
GGGGTAGTCAGATGAATGAGTGGGGAGGAATGAGTCAGGTGACCCTTGAGTTTTAAGGGCAGACTCCCAAGTAGGTGGCAGGGGTCCTGGAGGCAGGATGG
+
@@CFDDFFGGHHHIGIGIGIFHIIIHGGHIIIJIIIIGIBFHCGHIJJIJIIIIIIJJIIGJHHFHHFFDFCEEE>CB@CBDDD=@?ACCBDDDDDDBDCD
@3HA
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@@FDEDFBF?DBCF3CGHGGGIGHGC<H@G8?D@FHBDHDBB<BFBGAGIIGHHE;=D?CGHHF7@DBEDCAC@;>C33;?ABB9<A5@>@CCC@D@
@3HB
CCTTGCCTCTCTCTCCTCCACGGTCTTAGGGATCCCAAGGAAGAGAAGTGAGTGTGCGACCGAGCTCAGGGCCCAGGCTGGTTCATGCTATTCTTGCTTTT
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJFIJJGHHGIJIJHFDDDDDDDDDDDDDDDDDDDDDDDEDDDDEDEEEDDDDDD
@3HC
CTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTG
+
?@@B=A?DBHFHHIGEIHGGECFHIIIIIIIGEIGEGIIIGIBBHIIGEFIGFFHFEDEDEECCCBBB?CCCCCCCC>CC<@BBBCC:AC>ACACBCCCCC
@3HD
CACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTT
+
CCCFFFFDHHHHHJJJJJJJJJHJJJJJJJJJJJIJIJJJJJJJIJHHIJHIJJJJJJIIJIJJJJJHIIJJJJJJJJJJIIIHHHHHHFFFFEEEEEFEF
@3HE
TGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTC
+
@C@FFFDDHHDFDEGGIIGHGHGHIGGGHGIJEHGHHGHHIGHEGGEEHGFECDCBCCCDCBB@DDDB;@B@CCDDDDCDACDDDCBCCCDDDDDDD@BDB
@3HF
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CC@FFFFFFHHHFIIJIIIGEGHGCAEE6B@BCC@CCC@ACDDDEECDDDDDDD<BBDD<<@CCDA@CCDDDDDDDECCCDDDDDDDCDDCCCDC>CD?
@3HG
CACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGT
+
@@@DDD@BDFFHADEH?DHDFHCC7CFEEGBHEHDFEDDCC?AA;@?@?CCCCCA@CCBCCBCBB>;BBBCCCC@CCCC?BBBBBBBBBB@CBCCB?B@B2
@3HH
GGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGAAAGAGAGAGAAGAGAAAAA
+
CCCFBFAEB6FHHHIDHCHIC?CHH?FHCEGGDAG*?DGCDDCBGEGIIEC@FDHHIG@BEGGH>;7ACD>9??;@CEAECCCC?CCBBBBCCC@CCCCA
@3HI
GTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAAT
+
B@CFDEFFHHHHHJFEGIJIEIJJJJIIJJJIGIHIIIJGIJIIIJIJIIJJJJJJIIJIJIGEADHIJCFGDGEGEHCGIHHHHGHFFFFDDDDDDDDDD
@3HJ
CTGGATCCAAGTGAGGAGGCTCTCGCACAGCTCCGCCCGCTCCAGCGACTCTACGCTGAACATCTTCCCCGCCGCGGCCAGGCAGCGCCTACCGCCTGGCC
+
CCCFFFDFGHBFHJGIIGGGHGGEGIJJJJEHIJIJGIGIIHAHGIJEEFDFFDDCDDBCDDDCCDDDCC8;@BD@BDDBABD@BBBDDBBDD>BDBBD??
@3HK
CGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGGGCCGGCAATCACATCAACTTTC
+
?7@1BA=BF???DHFH:A4CC;CGHBD;;DCF@9C):?DF9BDFH:A65)87@CGHE'',9;3>;@??A:ACCACAC?'5>9@<<9<9:@:::>3:?>AA:
@3HL
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJJJJJJJEHIIGJJIJJIFGGHJJJJJJIIJJGHIJJJJIIIIJJJIJIJJJIJHGHGHFFBECFDEEDDDDDDADDCCCCDCDDD+
@3HM
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGG
+
@@@B?;B;?:<ACB<E;E@?;GEHIC@??EFFHA????8?@??D?B<BG?48)BFBGF;==)7=7.=7).';;;;;5.3,958',,5>::B:+44+43(2(
@3HN
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGT
+
@@@DDDDDFDAADEGIDHGHHIIIBAEGDGGIIEHGIIEGIBDEHHGICC@C>GEH;BDBCDCECECBBBBCCCCCCCCC@C:ABB<>2<>@CCCCCCCCC
@3HO
CCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGG
+
CCCFFFFFHHHHHJJJJJJJJJIJJJGIJJJJJJJJJIIGHIJJJJJJJGHIJDFHIJJJIJJJJJFDDD>BDDBDDDD9@DDDD5>BDEEDEDDDDD>BD
@3HP
GTGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGAGGCGTTCTCTTTCAGCATCTTCACGGCCACCGTGGTGTACC
+
@B@FFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJHJJJJJIIJJJHFFDDDDDDDDDDDDDDCDDDDDEEDDDDDDDDDBDDDDDDED
@3HQ
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
CCCFFDFFHHHHHJJHJJJJIJIJJIIIJJJJDGIJIJJJJJJHIIJHJJJJHGHHHFFFFFEDDEEDDDDDDDADDDDDDDDDDCCDDDDDDDDDEDDDD
@3HR
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCC
+
@@CDDDEDHHHGGIIIGGGCIIGIJJDHIGHHIGIIHIFHGEHHFGGIJFJJIDDGGEHHI@GIBEAAHBBEBAAEEEDCDCC?B9<@DDDDDD9@BCCCD
@3HS
GGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGT
+
CCCFFFFFHHGHHJJJJJJIJJJJJJJIIIJJJIIIJGHEHIIJIIHIJIHIJIJJJJJHHHH=BEFFFDDDEDDEFEEDDDDDDDDDDDD@ADDDDDDDD
@3HT
AGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCT
+
CCBFFFFFHHHHHJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJIIJJJJJJJJJIHHHHHHFFFFFFEEEEE
@3HU
CTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATC
+
???DAD;=<2<CDA<A<<33<33C?99+CAC1C??E?*:D??D<9:0009???D?D8D:8B8(@CI>78777).....7..=;7;6)..;AAAFA5>D;A
@3HV
CTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJIJJIJJJJJIJJJJJJJIJHHHHHFFFFDEEEECDDDDDDDDDDDDD
@3HW
GTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTG
+
BB@FDFFFHHHHHGHJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIIIJJJJJJHCHHHFFDFFEEDECEDDDDDDACCEEDDDCDDDDDDECDDDDD
@3HX
GTTTGCTCTTACCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCC
+
@@CFFFFFHHGHHJGIHIIJIJIIIHGHEHIFEHDHGHJJGBGEIGIIHHGGHEFEFFFEEDCDDDDDDDDDBD?BCDDDDDC?BDDDBB9<>CDDCCB@D
@3HY
CTTCCCGATACATTCCTGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATAC
+
CCCFFFFFGHHHGIDAADHGIIIJHJJJGJJJJJIJJJIJIIIIIIGAGEDDHGGIE=DDHGHI@?EHHHHHFFFFFFAEEDDDB@BDDDDDDDDDC@CAC
@3HZ
CAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCCGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTT
+
@BCDDFFDHGFHHIIJIJJJIIJJBHIJIIIIJIJJIIJIFJJBEIIIFHHGHGGEHEHGFFDDDCDDD<ACDCDDDCCDDDDD:@CDDCDBCDDDCCC4@
@3I0
CTTTATTTCTGCTCCTTTTGCTTTCTTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTT
+
CCCFFFFFHHHGHIJJJIGIJJJIJJJIJGJIJJJJJJJJJJJJJJIIJJJIJJIJGIIJJIIJJIIJJIIIJJJJJIJJJHHGHHEHFFFFEEEDEEEDD
@3I1
GAGCCATCCACCGAACTGGGAGCAGGCCTTCCCCTCTCTTTCTATAGTAATCATTTTTATAGATGTCTCTGGCGAGTCCAAAGTCTCCAATCTTCACTATC
+
@?;;BDDDFDF;FGBEEF>BFFI;?DFDG??B@>@?FDCEF49DFDFF@FFFEFGGDIA@@=:7CA;A7?=A>B8?B?@>>@<A>A>>ABB>A;@:>BBAB
@3I2
ATCAGATTGAGTAGTGAAGATTCCATCCATCAAACTTTCTGGAGCCATCCACCGAACTGGGAGCAGGCCTTCCCCTCTCTTTCTATAGTAATCATTTTTAT
+
=<?;DDB83C?<::2AE:C+<CFDAEDF>9CA<AC**:CCE9D8?DDBD8BD9@6DACAC9((5=@CDDDA>7@7>>((;-->>-;5(-(5>((5>B>A=>
@3I3
TGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGT
+
11:BDDD>DBDCD>A222CA?CE@><@422<C<:?CECA)??@<26@=A=4@CACDCD'39;;;>AAA??=::>AA<829>33(++(4(+44(+(+00958
@3I4
GGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJHIJJJJJJJJJJJJJJJJJJIJIIJJHHHHHHFFFDBDDDDDDDDCCDDDCDDDBDDDDDDDDB
@3I5
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGACCAGGCAATAAAATGAGAATTTGAAGGGT
+
@@@D?BDD8=,22+2ACF@;AACF1:8?FFECD<49*/8)8B>B@A9@FC=D>C=C4.?))7).)5',9;((,55982<?(,>>>B@:>4>>AA>>>>><(
@3I6
GTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCG
+
;@@DD?D?:=2ACE@GBAI<EFDF8:?CGG<GGCBD@DFCG9<FEIFI66ACEBB@9<;?>;9?A@@>@=9;<8A?(28::3>>>ABBBB182<@<<9@@&
@3I7
CCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCC
+
@@@DADDDHHHHHAFGGIGBGCGIGGFHGHBGEGI@DDGIGIEHGGIIIIGHFFDDEFECCCCABDDCDACDDDDDDDCCABDBDDDCD@C@ABB09>@C@
@3I8
TGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTG
+
CCCFFFFFHBFHHJJJGJJJJJJJGHIFHIJHIIIGHHHGIJJI@GGIIIGGHGGEHHIFHFEFFDDDDEDC>ADDDDDDDDDDDDDDDDDDDDDDDCDDC
@3I9
ACCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTT
+
@@?DDDDDF>3DCFFFDEAIIIA1@AFF<<BF;F?DF:GDG?DF?BBBD<<@A;72?>EEB<>BCB@BBFB<ABB:ABB95>:A(:A34@34:>A>>?B@@
@3IA
AATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTG
+
CCCFFFFFHHHHHJIJJJJJJJJIJJJJJJJJJJJIJJJJJJJJJJJJJJIIIJJJJIIIIJJJJJJIHIHHHHHFF3;BD@CDDEDDDDDDDDDDDDDDD
@3IB
GCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGT
+
<@<D;DDDFB?BB6FGH@HH<E@C;?6E>;?<BBDEG9FGGBBFDFFAGBC=BF@D>AGBEHHCHHC;?6;?;<>;@?BCC5:AA39>9?C9:>:>:A5?
@3IC
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCCFFFFFHHHHDIJJJIJHIJHIJJJJJJJJJJIJJIIJIJIJJJJJJJJEHIJJJJJJJJJHIIJHHHHHFFDDDDDDDDDDDACDEECDEDDDDDDDD
@3ID
CAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGC
+
@@?DDDEFGHGDDEG@EEFGE<GHEGEEHDDCC@BF<FG@D19588>@AC?9AADEDDDC@AAC>CB829?B<8@C@CCCCCCC@:>CCDCACC395>@AC
@3IE
CCAAAAATCATCTTTCGGTGGAGCGTCAGTGGGCTTTTGCTCCAAGGAGTGCCTGCTCATTTCAAACAGGAACCAATGGGGCCTCCAGCTCTCAAAG
+
???D;D?:D32CD?ACA)3C1+2CDE;8C9BD;BBDED<DD@D>D9C;C.(=A=)6AE;@AA?=ADA;A;;(6;>(5-((58',5<9(3>A>>:4>:
@3IF
TATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGT
+
CCCFFFFFHHHHHJJJJJJJJJJGHJJJJJJJJHIIJJJJ?GHJFHIJJJJHIJIIJHHFFFFFEEDEEDDDDDDDDDDDDDDDDDDDDDDEDDDDDDDDD
@3IG
TGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATAC
+
CCCFFFFFHHHHHJJJJFIJJJIJJIJJIJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJHHACEHFFEFFFEEEEEEEDDEDDEED
@3IH
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@@CFFFFFGHDFHGGG@EEHHIJIIGGHGFGGJIEGIIIJI3BGIIJIFIJIHIGJJGCHGGCFEGIEEEBB7;@CCEAACCDCCCC<C@B>CDD+9?BCC
@3II
GGTCAGCATTCTGGAGCAGGTGCATCACATGGTCCTCTGTCATGTTGCCATACTTGGTGGCATTCTGCATGGGCCCCTGGGGCAGGGCTCCCATGGGCAGC
+
@@=ADBDDD?<AC?DEGECB<AFE<CGFHIHI?EBGGHEHIIGDBGDHHGAFBFICB9?CCHIGEACFA@F=@CDHA;;;BC?C;@;@BBBBCCCA???>?
@3IJ
CTCAAGTAAAGGCCAACCAAGCCCTCGAGCAGTTATTCCCATGTCCTGTATAACCAATGGAAGTGGTGCAAACAGAAAACCAAGTCATACCAGTGCTGTCT
+
CCCFFFDDHHHHHIJJJIJFBHJJIIJJIIJIJIIJJJIIIEIIJIIJJHJIJIDGIIIIGGIEHI?ACEHFFFFFEEEEBA=?CDCDDCDDDDCDEDACC
@3IK
AATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTG
+
CCCFFFFFHHHGFIJJGIIIJJIJJIGIIIJJIGIIIJJIIIJGGGHIGGFHIIJJJIIIFDHCCHIIGHEHFHHFF9?BB;CCCDCD@CDDDBDDDBDDD
@3IL
GCCTCCTTCAGGAATTCAATCTTCTCCTGGTCTGTGGAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCAC
+
C@@FDFFFFHHHHGHGGIIIIFHHGIGIGIGFHH?CCBDFDHGGIJCFGEIHBFCIIIIGIGEHGGHEHCEHIGGJJHGGHGGHFFFFFEEECACEAA>@C
@3IM
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTT
+
CC@FDADDCFFHFIIIGHGDBDHFGGHDGEGDAHGBCHIGHIIGGGIBHDFFDECECEDD?CCCAC?<B<?<CCCDDDDCDCBD3<@B>@BCDCCCCDCCD
@3IN
GGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGC
+
?@@DDDDDCDFABAEFBF?BC?EBBHCECFGIIB>FHDFEHDH0@D8?BF?DGGEDHECEHIID=F;@@@AHHHEB88,>>:AACCC:::ACA9<AC@CBB
@3IO
CGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCT
+
CCCFFFFFHHHGGJJJJJGEIJJJHIGIJIJJIJJJJJGIIGIJJIIJJJJJJIJJFC8==DGHHJHGGHHFFFFFFFEEDD=>BCCDDDDDDDDDDDDDD
@3IP
CACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGG
+
@@@FDDFDHFHDHIIJJJJGJDB>HECEEEHHHIIGBFFHGIIIJIJIBBGHDHIJIG@FFHGGGHBB>;B>B@BDD@5>B<<5)5@DEEDEDCDBD>B>B
@3IQ
CCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATG
+
CCCFFFFFDFHGHJJJJJJJJJHHJIJJJJJJIFHIJDHIJIJJBCGIIJJJJIIHHHHFDDBDDDDACDDDD<?<CDECDDEDCDCDDDDDDDDDDDED
@3IR
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
CCCFFFFFGHHHHJJJJJJJIJJJJHJJJJIJJJJJJJJJJIHGIJHIJJJJJFHIJJHHFFFFEDEEDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDDD
@3IS
ATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCC
+
CCCFFFFFHHHHHJJJJJIIFHIIJIJIJJGGGHHIIJJJJJJJJJIJJIIGJIIIIJJJJJJJIJIJJJJIJJGJHHHHHDEFFFFEEEEEEDDDDDDDD
@3IT
GGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCAC
+
CCCFFFFFHHHHHJJJJJHJJJJJEHIIJIIJJIJJIIJIJJJJJIJJJJGHHIJIJJIIJJJJJJJJHHHHHFFFFEEEEEDDDDDDDDDDDDDDDDDD
@3IU
TTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACC
+
@CCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJFHIIJJJJJJJJJJJJJJJJJJJHHHHFFFFFFEEEEEEDDDDDDDDEDDDDEDD
@3IV
CTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCC
+
@CBFFFFFHGHHHJJIIJJIJJJJJJJJJJJJIFAD?BDDDDDDBDCCDDDBCDA@ACDCDDDCCDDBD@CCDDDDDDBDCCAC?BD:ACDDDDDBCBCDD
@3IW
GCCGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTT
+
CCCFFFFFHHHHHFFHHIJIIDHGHIJJHIFHIJJJHIHIJJ@GGIJIHHGHH@DFFF?ADBDBDDDBAB?BDDD9AC@CC@CCCDDDDDDDDDBDBBBDD
@3IX
GCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJHGIJJJJJJJJJJJJJJJIIJJJIJJ;EHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3IY
TTCCTCTTTCCTTTTGTGCTTTTCTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCT
+
BCBFFFFFHHHHHJJJHIIJJJJJJJJJJJFHIFHHIIIHIIHIIIIJJJJHHIJJJIGIIIJJJGJJJJJH?EHHFDCDFCEECEEEEDDDDDDDDDDDD
@3IZ
ACCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAGCACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTG
+
CCCFFFFFGHHHGJJJJJJJJJJJIJJJJJJJJJJJJJJIIIJJIJJJ3ECGHIIJJJJGIJJJIHIJJJJIGHHHHHHHHFFFFDEEEECCDCDDDDDDD
@3J0
TTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATT
+
@CCFFFDFFHGHGIIJJIIGHGGIJJCHDHIIJJEHGHFHJIGGEGHIIJJGGHHIH@?DDFDHIGEGGDGIGIIHJJHHEHFHFFDEBEF>CCCECCCCD
@3J1
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHHHHHIJJIIIIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJGJIJHGHHHFFFABD@DDDDDDDDDDDDDCDDDDDDDDDDDBBDDBD
@3J2
CTCAGTTACACACTTCTCAACTTGGAAGCTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTC
+
?=?D<,=2A4?:<+2A?:F4A<<C<FB3;E<@EDE*1*1:4C)0)*0?9DBDD4B*)((((8BBC));@).7).7=7?9;;)77@A>3>>3;;5;25=?>>
@3J3
CTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATG
+
?@@DDFDDFAFHHIIIFHDHIEGGGHIIIIGGHGCEGEHGEIIIIIIFGHCHIIG@;?DHGBHHIIGIIIIIIIIGGIGIIIIEDEEHEAEFEFFFFFEEE
@3J4
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
;?<DDDDDFH?FHEB@@BHAGCIIGEEDF<B?FGGCHGGBFIE;;FF>FDHC9@==AAEACDE;CD@>A;@>C?@B,;A;@>>5:?CCC>A4:38?C@<>@
@3J5
CTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATT
+
CCCFFFFFHDFAFIIHGGIFEH?CEBFGHDCGB?GHGGIIIIGBH>FHIEGAHIHF>CDEEDDB=?=:AAAC>C@@?CDDDCAC>@A??BDBD>@BBCCCC
@3J6
ACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTG
+
@@@DD@DDHDBBFIIBFEF?AFHEF??FB?DH9:::?:B?GIFHBBDD<B?DFG>CD4CFDHF@74==DHHIHEH>C?BDDDCC6>;;-5>CDCCBBB@BA
@3J7
GAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATCCTCTTCCTCTGCTTCCTTTTTCTTTTTCT
+
@CCFFDFDHHHFHHIDFH<FHHGIIIGGGIBDGIGHIGIEIJJJJI8BFFHHIGJIGIIJIGH?CEHFFFFFFECAEECCDDCCDDDCDDDDDDDDDDDDD
@3J8
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHHGJJJJJJJJJJJJIJIJJJJIJJJJIJJIJJIJIJJJIJJJJJIJJJJJJJJIGHHHHHHFFFFFFFDDD8?BD?CCDEDDCCDDD@DD
@3J9
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
@C@DDDDDFFHHFIIGIGIGHHHEHIBD86:BCCDD8<3>A8@ADDDDDDACD<2<5@DDACCCDCCDDDDDCD@CDC@CCB9>@<CC@B>AC:A4:<A
@3JA
CAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJHIJJIJJJJJJJJJJJJJJJIJJJJJHHFFFFFFDDDDDDDDDDDEDEEDDDDDDDDDDDDDDDDDDD
@3JB
CAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGC
+
<?@?D3ABF6FFFIEGDIHHA?FC:F9AD4C:EA>EBGGFEGFIE>DE?8@?C)8=C@F;FFC7777;@=7?ECC<B?;?@89<>>@B:?:>AA33:><@B
@3JC
TCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTT
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJIJJJJJIIJIIIJJJJJJJJICHHHHHHHHFFFFFFDEEDDDDDDDDEDDDCDDDEFDDDDDDDDD
@3JD
CTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTC
+
C@@FFFFFFDFCFHHHHIIFGGIIJGAHHGHEFHGGHIGIEIHIJGIIGEDHHIHHIJIIGIHECDFEEHEGEEGEGIIIGAACCEHCCDDFFEFECEEEE
@3JE
GTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTAACCTGCCGCCTTAAATCACCAAGGT
+
CCCFFDEFHHGGHJIGIIJJGGIIEGIJEDFHGIGEHIJI@G@DF<FIIGIIJGIHJJJJADCDHIIJJIDGBFHHIIGGHGGEHFFFEEEDEEDDDDDD5
@3JF
TGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCC
+
CCCFFFFFHHHGHIJJJJIIJJJJJJIJJIGJJJJJJIIJJJJJIIIJJIIJJIJIFGHIIJIJJJJJIJIIIJIGIIIGHHHHFFFFFFEEEEEDEDDD
@3JG
CAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTC
+
CCCFFFFFHHHHHJJJJGIJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJJIIIIIJJJJJJJJJIHJJHHHHHFFFFFEEEDEDDDDDDDD@CCDDDDDEF
@3JH
GGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGT
+
B@@FFFFFGHFGHJEIJGJJJJIJJFIIIEIIJJJGGGHIIIHJJGIJGHIJJHHIJIJJJJHHIJJJJJIJIJHHHHEFHDFFFEEDEEEEDDDDDDDA
@3JI
GTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTG
+
@@@FFDFFHDHFAHIJJJJJIGGHGJJJIIEGGIJJIJJJJIJFIGJIIIEDFFAHHGGHIJJIIJJJJGCIIGGGE@EEEFFHFFFFFEDEEDECCCDDC
@3JJ
CTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTC
+
:??DDBDBAC?A?:<:<2<FFF:??AFFBFDEDD9D?DDDBDIIEDEBC;BB@CC@CCEA@@>CCD?;;;55;;>AAAAA:<>AA<5=9:>::>A9>4(44
@3JK
CACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTC
+
CCCFFFFFDHHHHIJJJJJJJJJJJJJJJJIJJJJJJJJJIJJJJIIIJJJJIIIJJJIJJGJIJJIJJJIJJIGGIJJJIJHHHFDCCEEEECDDDD
@3JL
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
CCCFFDFFHHHHHJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJ=FHHGGHHHHHFDFFFFFEDECCDDDDDDDDDDBBD
@3JM
GTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACAT
+
?@@DABDA?FHDBFAGEHI@IHIID?FGBHHIB????FDGGEIGIGG@G9FDHGI>DHHEH9@;A=EGHEHBEDECCCCCCBACCBBBBABCCCCCAACCC
@3JN
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATAT
+
@CCFFFFFHHHHGIIJIJJHIGGIIIJJJJJIIIGJJJJJJIJIJJIJIIGIIIJJJJJIJJGHIGCDHEHFHFDEFFEEDECEDDDDCDACBCCDDDDDD
@3JO
GGTTCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGC
+
?@8BAABD<FB0)<A@<B>BD:AAH<<F??:::::C8BFG>DGI0;;(.8C;@EEE?EFFBDD><39;9<,:::<;28>>:@::444(4+:@AB:<A9@3
@3JP
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@<;?=D:BDBDFAEG?<GCFGB?@CEHCHH:C<GGE8@GH3?F>09D?DD<C@BB@GCDH)>@GE>E=AEE5?=<DCCCCDDC@A>A/;==@CCC3@:+4>
@3JQ
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@C@?DDFDBFFDDHAFGI@@FGDFEAGIGGGGGGGIIGICBFEECFHEG@=C@CHHGCCB@BBEECA6>>;>@CDCCCACCDBCA@CC?>CDD8<<?@>:?
@3JR
GGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGG
+
@@7BDDD:+AD???9CD@FGFEICFEHFAGEFFCGC>CABGE:D@BGFFBFFE@F:<FFG7@FE=FGCEFCE=@??AEEEB;BBDBCCAAA@BBDEBA
@3JS
CTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATC
+
?@@FDDFFHD?DHHEGGGIGHIIGIEH@HG@HGGIFIIIGIGHHGHIHHHHIFEHEFFGIHFHHIHGBBBGHGIGGGGIGGGHGIHIIHHCCEAB?DFFB
@3JT
CGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCG
+
CCCFFDFFHHHHHJJJJJJJJJJJJJJJJJHIJJJJJIJJJJJJJHIIJJHHFFDEEEEDEEDEDDDDDDDDDDDDDABDDDDDDDDDEDDDDEDDDDDDD
@3JU
CACAAATGGAGGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTCGAATTGAGGGCAGTCTGAGTAAGGATAAAGTTCTGAGTTTGAGAGG
+
@@@FFFFEFHHHAEGH@DGGHGGGIIIIIDAGFIIIIIIIG;FHHGGIIIHEFCECACCBCCCCB@B?9ACC>@ACCCC@ACCCCDCADCDCCECCCBB>B
@3JV
CTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATAT
+
@@@DDBDDCAFFDEGGI2AICHIAAFCHHHHGDFE??FE@HHG@?GHHHGDHIAFHECGGGF@FGGEGIIIE)=7A??CEE<=;;C@CAACC;CD?CADCC
@3JW
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CC@FFDFFHHHGHJJJJJJJIIIJDGIHIJJJGIHIAGIJJJJJIJGIIIIIIGHFHFFFFFDCDEEEEDDDDDDDEEEEDDDDCDDDDDDDDDDDBDDC
@3JX
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
CCCFFFFFHHHHHJJJJJJJJJJIJGHHJFHIJ:DFHHIJJJJJBFHIJHIJJJJJJIJGHHHHFF?BCEDEDDDDDCCDDDDDDDDDDDDDDDEDEEEDD
@3JY
CCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAAT
+
??;;=DBDA<4B<CD+<33A?@EFF9FI92+):E;DDDII@99BDBD4BDD;@??DBDB=CDDEC4)@=).)).).==?;49=>'>;5>:>A>:555>59A
@3JZ
CAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTC
+
CCCFFFFFHHHHHJJJJJJIBHIJJGJGJJIHIJIIJIIGIGIJIJIIJJIJJJJJJHHHGHFFFEFDDEEDCDDDDDDD?BDBDDCCCDDD>BDDDDDDD
@3K0
GGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTG
+
++:ADDDDFF4<AB9CFF>IECB::A<C?<C>)?CD1)306;?DF9/*99?(6@F-09&3(:@>(49((4>::4AB2:@A882&28?1(+44(:4:@9+++
@3K1
GCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCC
+
CCCFFFFFHBHHHJIGGGIGGGIGGIJ@DGHHIIIIJIIJIEHGJJIIJGGEDGGFCHHEEBEFEFFCCEEDEEDDBDBDDD<C:AABBDDEEDDDEDED
@3K2
GCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTC
+
=11AA;DD?:CCD4CE>:<AF@E?:CE<FDFFCCF>:C>A1?D@DD>?D?D*0:BD?@?@DBDD8=888==C@CE7CD@A:@C7?CCDD;?;7;@AD@AA3
@3K3
CTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTT
+
@BBFFFFFHHHHHJJJJJJJJIJJJJJJJJIIJIJJHIJJJHJJJJJJJJIIJJJJHJJJJJIIJJJIIJJIJJJJJGIIHIJJIHHGFHHHFFFFFFFEE
@3K4
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
@@@DDFFFGDFHGFHDHEHIIIBCHIIIGGIIIIAGIIIFHGIHAFHIIIGIGIHHIDGHIGIEHGIGEGHII):?BCB@@C>@DCDDECCDCCDCDB@CB
@3K5
CGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGG
+
@CCFFFDDHHHHHJIHIJJJJJJJJJJIJJJJIJIJJJGIJIJIJJJGIIIJJJJJJJJJJJJJGHHHHHFFFFBDDED>@ADDFDDDDDDDDCCDDDDDD
@3K6
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
@@<DDBD?DDFFFHIIIIII?8?BGGIIIBGG?BG@FE?FCD<FAHIG@>FEC7@EEHIHCHEH@CD@@BCCCA>BCC@>CCC@C@CCB55>>>CCCCBCC
@3K7
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJJHIIJJIGGIEGIJJHIJJIIJIJIIJJIFIIJJIIGGGGIIIHEHGHHFFFCCEEDACCDDDCCEDEDDDDDDCDDDDDC
@3K8
CTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGT
+
CCCFFBDEDHDHHHIHIJIIIGJJIJJJJJHJJJJIII:???FGIJJIJIHIJIIIGGIGEEHFFFFFFEDEEEDDDEEEEDDEEDDEEDDDDDDDDDDDC
@3K9
CCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGCTCATTCAGCAGACAAACTCCAAGCTGCTTCAGA
+
????1DD=DD<D:EEA@E<99C<91C3EEA*:**0?DDDC99909?9?@B=8.=78A:/==@==A<'5;)7?3;AA3.;===;2-((,>51>>AA3>(++
@3KA
CTGTTCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTGCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTC
+
??8==A2B=B3:+<EEEACFADFFECAFFD<+2C<E>EEEEEE<CDF?C@DD4**0?0<?99*/98??*).=8@@=A4@C4)=7.7ADA>;A?BD:@=6>(
@3KB
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@@CFFFFFHHHHGJJJIJJJIJJIFHIJJFIIIEHIIJIDGBHHIJJJIEGIIIHFHFFEFFFEEEEEEDDBCCDDCDFEACDCDDCDDDDDDCCDBDDC
@3KC
CGCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTT
+
@@@DADDACBFHHEA?<EIHH4CHH@<CEH<F>EBEDDFEDAC>FEHIIADFD9?DEFDC?DFHIII=3@FGE;CHE=CCECE;A;B7??A@@?@AC;@;@
@3KD
TGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTT
+
B@CDDFFFGHHHHGGHJJIIIGIIJIJJJJJIGGGHIIJFIIEGHGGIIGIIJIJIJBFHJJJJJJJJJJJJGIGIGIIIHGHH=BDFFEEEEEEEEDDD
@3KE
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
@@@DB;D@:0:C0<AECFDHHFIC??EFGF0?DFFFFI>FGIEBBFDFCFD>CFFFIE;=.7;CEEDBDD1@CA@>@BBBBBB9@BB9A:>:<+3::>BB
@3KF
GCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGACCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGT
+
C@CFFFFFHHHFFIJJJJJIJJJJJIIJJJJJJJJIJJIJIJIJJJHHHHFFFFDEDEDCDCDCDDDACDDBDDCCDDDCEDDDDDDDDDDDDDBBD8AB9
@3KG
GTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
CBCFFFEFHHHHHIJJJJJJJJJGGIJJIIJJJJGHIJJJJIJIJJIJIJCGIIJJJJJJJIIJJIIJJHHHHGHFFFDDEDDDDDDDEDDDDDDDDDDD
@3KH
GCTCATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTC
+
CCCFFFFFHHHHHIJJJJJIJJJJJJJJJJJJJHIIJJJJJJIJJIIJJJJJJJJJJJJJJJJIJJIIJJJJJJIJJJJJJJJJJJHHHHHHHFFFFFFF
@3KI
CTTCACCTTGGCCACATTCTGTAGCAAGTACCATGTAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAA
+
@@@FFFFFFDFHFIIGHGIIIHIJJGGIJIIIHG9CEFHHGIIIJIHIHGHIGFHGIIJIIIIGGCHIIGGCGIJHGHGFEEDCEDEEECCA@CDDEDDD
@3KJ
CTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTC
+
@@@DDDBDDF2AF@FHEHHIIGHCHFFI<?HH@CEDD?EFHIGIBHFHGBGEHGGIIEDGHIEA?FFHEEFBCFGG@;7@DDEEEA=ACHE?@?BCDCCCC
@3KK
CAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCT
+
CCCFFFFFHHHHHJJJJJJJFJIJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJHHHHFFFFFFEEEEEEEDDDE
@3KL
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTC
+
@@@DDEFFHHBHHJIJJJJJIJJIJJJJJJIGIDIIJIJJJFHCFIGIJEIIIIGJJDDHFHHHGBDDEEEEEDDDDDCDDDEDDC@DCDCCCCDCDDDEC
@3KM
GCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCC
+
?;?AD?DDADF?FFF@FE?BCGEEHC?BAC<EHFED>F3C9?FGIEB?BFBF>F3D4<FFGI38B(B37@3@DE@7@ECE3?EFDFB;B37@36>>>A>A@
@3KN
CCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTC
+
?@<1ADDDFDFD:A?<GADI??CECACBDCHIIFIIFGEBBF??BGBDD9?DBFGCB??B@=;/===ACC6?EEEC??>)?@@@ADA6@ADBAB@B@ABB@
@3KO
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCT
+
CCCFFFFFGHHHHJJJJIJJJFHIJHJJJJJFHIJIJJJIJIJIIJJIJJJIJJJIJFHIIJJJJIJIJJJJIHHHHHFFFFFFDDDDDDDDDDCDDDDDD
@3KP
GCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJBGGIJJIIIIIIGIIIGGHGIDEEHHIEHFHHHE@CBCECE>ABDDDACDCDDCDDD
@3KQ
GAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGC
+
CC@FFFFFHHGHHJIJIGIJIIIJIJJJJJJJJFGIIJIIIGGJJJJJJJJJJCEHEDFFECCEEEDCDDDDDDDDDDDCDD??BDDDDDDDBDDDDEDDD
@3KR
ATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGG
+
CCCFF4BDHHHH?FHFFHIIJJJJJJJIJJJIJJIJJEHJIJIIGIHJIJIIJJFEHHHHFFFFFFEEEDEEEDDDDDDCDDDBADCCCDDDDDAADCDDD
@3KS
CACTCGTGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGC
+
@C@FFFDDFHFHHIGBGIJJGIJJIGGIHIJJIIIIIIJJJGCHJJJJJIGIJIFGIHGHHFFFFEDEEEEDDD;@D;CCDCCCBDD?BDDDDDDDDDCDD
@3KT
CCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
@@@FDFFDHHBFFIJJGIJJGEHEDF@B4BGCFEHHJGE@;C@FE6EEC@@@@CEDE>>;?BDBDC>CCCDDCC>B:@C44@BDDA?C>CC8@B?C<CC@C
@3KU
GGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAA
+
@@=DDDFFHHHFHIJJJJJJJIJEHGIJJHGIJIIIIIJJIIIIHGIHHFFFFEEDBDCDD>@=<ACDDDDEEEDDCDDDDCC>@>>ACCDDDDDCDDDD
@3KV
CCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAA
+
CCCFFFADHHGAFIIGHGIIIIIIGEGFI@FHIIIIIIIIIIIIHIIIIG8;FGHGHCGIIHHBEHGHHFFDFACE@ACCCCCCEEDCCCCCCCCCCABC
@3KW
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTT
+
@@<DDFFFHFDBDIIIIBIHCGGGIJIFHHGCFGGBGEBHGCHFGBDEFHEGH@FEA=DA.7=AHBC@BCCCCECEED;?C:?@CADD@C:@:CDDCCDDD
@3KX
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
@CCFFDEFHHHHHJJJIGJJGIJIEIIGHGIJIJIJJJEFFIJGJFFFHGIJIJJJIGIIHJJIGIDA?BDE@CEE;CCCDDDDBDDDDDDDDDBDCCBD
@3KY
AGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJFHIIJJJJJJJJJIJJJJJIJGIJJJJJJJJJHDCDEEEDDDDDDFDDDDDDDDDDDDDDDDDDDDDDDDDDEEDC
@3KZ
GTCCCGCTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGGGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGAC
+
<@@DDAD<FFFBDDGGDB;CFCD2<?ECGG?<CD;DGEEH>F99BF?09D<;F@CGGCEGD(;6?CD;?BCBA>3@>BCCCC@CCACECB>CCCCCCC>:>
@3L0
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATAT
+
??@DDFBAFFB?BFGFBEADGEHAFCH3??FDGH:B?BHBB>BEFGGC@BBFHIDE4;CEEHHE>@B;;>@CCA19?@CCCCC>>C;ADCCCCCC@A>@CA
@3L1
CCCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAG
+
C@CFFFFFGGGGFIIJJIIIJIGHIGIIJJGIJJJJJIJJHGIIJIIJGIHIJIIJJIJJJIJJJIJJIIJHHHEFFCDDEDDDEDCCBDDD9>>8<A
@3L2
CGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACAT
+
CCCFFFDEHGFHDGGIIHIJJJJJGHII<CEHGIIIIJJGHIJJJJJIJJIJIIIIHHHFFFFFFEEEEEEDDDDDEEDEDDDDDDDDDDEEEDDCDDDDD
@3L3
CTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJJJJJJJ?HHHIJJJJJJJJJJJJJJJJHJJJJJJJHHFDBDDDEDDDDDDDEDDDDDDDDDDDDDD
@3L4
TTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGGATTTG
+
CCCFFFFFHHHHHIIJJJJJIJIJJJHJJIJJJJIJJJIJJCGIJJJJJJJJJIIJIIJIJFEHIJJJIIJJIJJJJJIIJIJIHEHCDFEFFEEEEEEDD
@3L5
TGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTT
+
CCCFFFFFHHHFHJJJJJJJJJJIJJIJJJJJCHIIIJJIIHIJJIJJJJJIHGIIJHGHHIJJJJJJJIJIJIJIIIJJJGIFHHHHHHCFFEFFEEEEE
@3L6
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGT
+
@B@FFFFFHHHHHJJJJIJJIIJJEHGGHHIHIJGIFGIIJIEEHFHIIJJJJJJJJ@D>EHEAEEFFFFFEDEDDDCDBDCDEDDD@CCADDDDCCCDCC
@3L7
CCGAGGCGATCTGACTGGCAATGTGGAGCATTTGGGAGAGCCCCAGCTCACCCTTGGCCTGGCGTGGCTGTCCATCCACAAGGATCATTGCATCTGGCCC
+
CC@FFFFAFHFFHGGIGIJGEHIIIFFDGGHIJGCGHJJIGHGIGIJIJHHHHFFFEDCEA=@>9?BDDDBDDDEDDDDCDDD?CDDDEDDDEDD@A@BD
@3L8
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGT
+
B@BFFFFFHCCCDGHGIJJIIHHJIIIIIJIJIIJJJJIIIIIGJIJJJJIGIGJJJJHHEEFEEFFDDDDDDCDCDDDDDDDDDEDDDCDDDCCEDCDD<
@3L9
CGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFEEEEEEDDDD;@DBDDDDDDDDDDDDDDDDDDDD
@3LA
TTTTTCTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGG
+
@C<DDFDEHFGHHICHGICHIIIIDHHHEHDEBFGEG@HHIB?@?DDGGHHEIIGHFIHBHEGECH>FAHII?<EAC@DFFFECB;>ACCCDCDDDDDDDA
@3LB
TAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAA
+
@@CFDDDFGFHFFAGGGHGIIIIJJJIIJIJGGGIIGEGECBBEGIIIHIJIJIGC@DD=CAEAHDF?=?A;@:=BBBB@CDCC>@AABCA@AACC>CAC
@3LC
CCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCC
+
;?@BB=DDHHHHHGHD@GGEGGEA?BBG@FGIIIIGHEFIIG;B@F@AABEHFEEDEE>CCCA>?CC@ACCB@CCCCACC<?<BC<?CCCCCC?B<@>0>@
@3LD
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
@@@FDFBDHHHHHIJJJJJJHIJJJJJJJJJJJJJJJJIJIIHHIGIJIDGFIIEGIIIJIJJJJJ7CEGEHHF5?AC>CCDDDD?ACDDDDCDDDDDDDD
@3LE
TGAGAATTCAAACTGGCATACTGGCCCATGGAATTATTCATCTCTTTGTTCAGGTAGAGGAAGCAAAAGTTACCAACATTAAAAAAAATGTTTTTAAAGA
+
?;?BDEFFFFHDHFBEEFHIIDHCEHIGGGDGGGGIGEGCDHD@GHIGIEIIIE?DGEFCHGEGGG>GH@DAEDHIBEAEDDDDFCCCCCCCDCBBCCCC
@3LF
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
CCCFFFFFHHHHHJGIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHABDCDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDDDDD
@3LG
CAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTCCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCT
+
?@@DDDEFHFHHBGEGIIIIGHGEHHGEHAFHH<?FC9CCED?DBGGIIIEIEDGHGHII@FHHIGBGHBHGIGGGIHIHGICHEEHHHF;;BDF@>BE:A
@3LH
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCT
+
CCCFFFFFHHHDACGIIJIGFGIJIJIGGGIIIIIJJJIJJJJIJJIGEGHIJGIJIAFIIJIIFIHHHHFFFFDCCCEDDCDDDDDDDCDCDDDDDDDBB
@3LI
GTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGGTACACTGC
+
@@@DBDDFFFDFHIIBCGGIIIEGGIGIIIIIIIIIFGHEHICDCGHHIIGEGIGIFEHHHFFFDDBBEEDDDDDCDDACC5<CACDD<>>BD9<BDDDCD
@3LJ
CATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTT
+
CCCFFFDFHHHHHIJJJJJJIJJJAFHHJJGIJJJJJJJJJJIJJJJJJJJJJJIJJJIJJJIIIIIJJEHIHHHHHHF?CBDEEEEDDDDDDDDEDEDEE
@3LK
CAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGC
+
@@?DDDDDF?@DF;EFGBFHIHIFAHICHHGEBFGGHIGHIFH@BGB?FGGIIB<BBFD<FH=CGBFGEH@GCD7CEHC>AEHHF>DDECEE>ACCA@C@>
@3LL
GTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATC
+
CCCFFFFFHHHGHJJJIIIIJJJJJJJJJJJJIIJJJJJIJIJIIIGHIGHHIJIJIGIJJJIJJJIJJDHGGJJGIGIIHFGHHHFFFFCDEEE>CCDDD
@3LM
CCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAAT
+
C@CFFFFFGHGDHGIJFGIGIHJCFEFHGIIJJI@FHCHIJJIJBFGGFEHHIGHFDFDDEDCCBCC?DEDDD>CDBDCDCDCCDDDDD@BDDD>BBBDDD
@3LN
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHGHHHJJJIIJJJJJIJJIHIJIJJJJJJJJJJHHIJJJJIJJJJJJJJJJJJJJIJJJHHHFFEFFEEEEEDDDDDDD?CDDDDDDBCDD
@3LO
GGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTC
+
CCCFFFFFHHHHHJJJGHIJFHIJJJJJIJJJJJJJIJIJJJIJIJJJJJJIIIHHHHHFFFFFEEDDDDDDBDDDDDDDDDDD@DDDDDDDDDDDEDCDD
@3LP
TGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGG
+
?@@DDDBD?A:DF<DGBAE@H@<BHC8?EE1CG<??DHGD>@><*?D>;(9;<BF<F)8==8@@78)@:7=E)=.7?7).,9A?B>>3;A@C5>258?9
@3LQ
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
CCCFFFFFHHHHHJJFJJJIJJJJJJJJJJHHIJIIJHIHIIIIJIIJJJIIJJFHHJGHII;CEHEHHFDFF;AECECDCDDDDDDDDDDDDDD>BDDDD
@3LR
CTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCG
+
@@@DFBEFHDHHHJIIJJJIJGGIJJJIJIJIJIIGHHGIJIJGIIJIJFGHIIJJGIIIGIJJEHHGHIJEHHGGFFFFFFDDCECED@CCBCCDCDEDB
@3LS
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCT
+
CCCFFFFFHHHHHJJJJJJJJJIIJJJJIIJJJIJIJJJJJJJJIIIIIIIIIIJJIIJJJJJJJIJJCHHHEHFF;@ADACCDDDDBACDDDDDDDDDDD
@3LT
CTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAAAATGGACTTAAGCTATAGCTTG
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJHHHHHFFFFFEEEEFEEDDDEDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEEDDDD
@3LU
CCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGG
+
CCCFFFFFHHHHHEIGHIHFHIJIIJGCGGHGIJJIGGJGGIJIIGHJJJIIJJEEFHFFDDEDDDDDCCDCBCDDDDDDBDDDDCDCBBDDDCDCDCCDC
@3LV
CTCCGGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFF<DDHHBHHJGIGGHEAHGHGIIEHJCHGDHIIJ?DA@CHIJFDGHEFEEDFEFEDEDDEEDDBB@8<A@>@CACCDDAC>8AAC@DEC:4>ACDD
@3LW
ATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
@CCFDFFFHHFHHJGGHGBHGIIIIGGIJFHIIIIGJJJGEFFHGEDHGIGHJGGHFHHCEDDFFF@CEEDDDDCDDDACCDDDDCDCCACDDDDBDDDDE
@3LX
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
:?;?DAA@<CFHH<GE@FGCHIB;2?;BGBGGGGE>>BGG>098B<@@9./87.@@6@;CCAHE<;B;B:;3;@>93>C(3-;55(5:55,'(,:?103))
@3LY
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
CCCFFFFFHHHHHJJIHHIJJJJJJIJJJJGHIJJJJJJJJJJJJJJJJJJJJJJJJJJGIHJJIHJHHHHHFFFFBEEDEEDD5??BCDDDDDD?ACDDC
@3LZ
GGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGCGGCCTCTCATCTCTTTTCT
+
?@;?BDD;?A:CF>@A>4CAGA2?:EGBAF?)@>@GADBGBFFI8BEF?>BBDACC;A;AB9;;'808@B>A>95?>BBBB(59&09?AAA:AABBBB:::
@3M0
ATTTGTGGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGTTTTGATTTTCAAGCACTGCCACTCTGTTTTCTAAACATTTCACATAT
+
CCCFFDFFHGFFDCFHE<AFHHGHB<F<EHGIHAHIEHEGGHGEEHGHIIIHIGHIIGDHGIIG@HCHHIIIIIIEEHFHCEFCDBDBDCCEEFEEC:>AD
@3M1
CTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
@<@BDB?DDFHHDGEBH>FHIGIFIHIIICHIGFHCGEHIIIII9BGGGGEE?=BCGEEIIE@D=@@EEEFDHHHFECCDBDCCCACCCCB@BB@5?A
@3M2
CCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCT
+
?@@D;D>BCFFHHIHEEGGB:FB<EAHHH9FH>HGIGGH@G9FHBDH:B@GA<?<FGGH:FGEDBBBCBFB:F@FHHEI);?=A@C>>@7@:ADC>CD;;A
@3M3
GGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTTTTG
+
@@@D=DDDFF?<<CEEAFHHEGHG<?DCGGGEFHGHII9@FFDHDBBEECAC@@C>>5>ADDDECC>AACC@CBBBBCCCC?BBBCCCBBB>B@?@CCCCA
@3M4
CGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATAT
+
1???DA?;::DD?DED@E:A+AA<ACFEEACE?;@D9?B9B*9?DDD.<5@>))=CCDD6?;A)>@@>A>A5>;5,;88?75:+(:>3:>>>:>?>A4>:>
@3M5
CCCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTT
+
CCCFFFFFGHHHGJJJJJIJJJJJJIJJJIJJJJJGHIJIJJJJJJJJJJJJJJIJJJJJJJJJJJJJIGHI@DHHHFHHHHCFFEFFEEEEEEEDDDD;A
@3M6
GTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTG
+
CCCFFFFFHHHHHJJJJIJJIJJJIJIJJJJJJJJJIIIJJJJJJIIJIJJJJIJJIIIJJJJIIIIIJIIHFHFFFDEDDEEDDDDDDDDDDDDDDDDDD
@3M7
CTTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGG
+
@C@DFFBEBHHFHHGIJGGHIEEGAFCDGHIDEGIIEGBFHGFGEGGGGIJJGDAAHFFDCCCDCCDDDCCDACDDDDDDDCCCD>>BBBDDDCDCCACCB
@3M8
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTA
+
@@@F?DDFFHFCBGGHBGGCHIEHGGII?GFE?FHHFEHIFEGIEHGBCFHIFHCHGIFEHHFFFFFDDA>BDDCC@CDD:>A@CCDDDDDCDDDC:>
@3M9
CCTGCCTTCTCCTTGGGGGTCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGT
+
CCCFFFFFGHHHHJJIJJJFGIJJJJIJJJJJJJJJJJJIJJJJJJJIIHGJIJJJHFHFFFFEEEEEDDCDDDDDDDDDDDEDDDDDDDDDDDDDDDEED
@3MA
CATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJH?1::CGHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHHHHHFFFFFFEEEEEEEEEEDDDDDDDDDCDCDDC
@3MB
GCAGATGCTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAA
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJJJIJJJJJJJJJJJJJJIIJJJJJJJJJJJJJHIJJJ@BEHFFFDDEEDDDDCDDDDDDDDDEDDDDDDD
@3MC
CGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGGCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJIJ'7@GIJJJJJGIJHHFFFEEEEEEEDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3MD
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGT
+
CCCFFFFFHGHDHIIJGIJJJHJJJJJHHIJJIIJJJJJJIJGGIIJJHHIIIIIJGEHHHFFFDDDDDCDDDDDBDDDCACBDDCBCCDDDEDDDDDDD?
@3ME
CCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACAC
+
CCCFFFDEHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJHHHHHFFFFDDEDDDDDDDDDDDDDDDD>CDDDDDDDDEEEDDD
@3MF
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCGCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
?;7=B:D?:FB>DGA<DGE:@EGFBAE>B?9CD<<<9DD0..7;F4BAFCFEFF9D?>EEE;9',9>;5>A(:<8;?B>AABBA@@>@>:<25<5?@A(+4
@3MG
GGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTG
+
:88DAD;DFDFFFI9CAEDCBGIFIF;BDAEEEFI9DDFC@1BFFFFF@D@=ACF=7=BD@=@A;>A;>BBBBBB3:9AA>55<3880238?9>&)8A>:9
@3MH
GGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGAT
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJIJJJIJJJJGIJJJJIIJJIJJIIJJJJIJJJIJIJHHHHHFFFFECEDDEEDDDDDDDDDDDEDDDDDDDE
@3MI
CTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTGTTTGC
+
<??=B:A?:+2<<28?)2A?CBCBC>1C)?)?*::**0*0/*(()8@AA@'=?<@.;6(((5;(--((,:(:<AA((((((3::(4>44+444(+(+8((+
@3MJ
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJHHHIJJJJJJIJJJHIJJJJJJJJJIJJJJJJJJJJJJHHHFFEEEEEEEDDDDDDDDDDCDDDCDDD8
@3MK
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFDFHHGGGJJJIFFHGHJJJJJIJJJDFHIJJJJJJJFIJIIIJJIJJFGIIIJJGGEHHFHHHFFFFFFCE>AEDCDDD8>BBACDDCDD?BC
@3ML
CCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCTTGCCAGCAAAGCAGTAGT
+
CCCFFFFDHHHHHJJJJJJJJJJJJJJIJJJJJJJDGHJIHIJJJJJJJHFDDDDDDDDDDDDDDDCDDDDDDDDDDBDDDDDDDDDDDDDDDDDDDDDDD
@3MM
CAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTT
+
CCCFFFADHHHHHJJHIIIJJJJIJJJJJJJJJHIIJJJJJJJJJJJJJJGHJJIIIJJJIJJIJJJJIIJJGIJGIJJDGIJJEHHHHHHHFFFFFFFD
@3MN
CGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTG
+
@@CDDDFFFHHHHJJJJIAHIGIEGGEHIJJIIJIJIIIIGJJJJJHIIHGGHGFHFFFFDEFEEEDDDCDDEDEDCDDDDDCDDCEEDDDCDDDDCCDDD
@3MO
AATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGGCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGC
+
;<@ADDD;C:AFCGBF3A@EHEBHEIEFEBFB>B@F@GFGG?GGFEFC)?@FFICGGGF@@@=C>@FE:CDEEEEA7?CB@@?BBBBBCCCCBB@5@;A;A
@3MP
AATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCATCTCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTG
+
;??DDDDDFBDCFHE<FCA4:C<FHIBHCCHCAGDDCFHF@?C>@?:DH?BFGGB???B@FBGIIF@GGI=FICC@@7@@@=?>AC???DEC?B;?CCAC:
@3MQ
CTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATC
+
CCCFFDFFHHHHHJJIJJJJJJJJIJJGJJJJJJJJBFIJJJDGHIGIJJJJFGHIIHIIIJJJBAGGGIJJJ=?EHHHFFFDDDDDDDFDECDDDDDDD
@3MR
AGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTG
+
CCCFFFFFHHHHHIIJJJJJJJJJJIJIJJJJJJJJJHHIJJJJ@FHJGGIJJJJ@GIJHHFFFFDEEEEDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDD
@3MS
TTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGA
+
=??BABDADDC:AA<C@?CC<AFHB<EHE>AFEF;@8C?@@CDBGF<<??BDAGGGIIHAEEGG8@ACHGAAEAEFC2?B;@CEECCC@C@CC>@>A@CC
@3MT
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
CCCFFFFFHHHHGJJJGHHIJJJJJJJIJIEHIIIJJJJJJJJJJJIJJJJJIJJJIJJHIGIJ7DHHHHHHFFFF@CEDEEDD@DBDCDDDDDD?BCDDC
@3MU
GACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCT
+
@B@FDFFFHHHHHJJJJJJIIJJIJJIJJJJJIJIJJIJJJJJJIGIGIIJHHHHFFFFFEEEECCCDDDDDDDDDCDDBBCDDDDD
@3MV
GGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCT
+
@@@DBDDFHHHFHGFDFEGHGIGEB;FGGFEGIEFHI=GFEAHHIIEHGHHFFF>CC@AACB6@BDBBDB@BDDDDD@@>@CDCCCC>A<?B39<BDDBBD
@3MW
CTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@@DDBDDHDBBFCCGHDADFCE?1CF?BD<FG9@GCGHEG;FHCHH@EEGGGHEHEE>7;BCBCCCCCCCAC@ACCCCCCCCCCCCCC@A@CBB?BBBCC
@3MX
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@??DDDDAHDHF?FEEGEFFGIEGHGB<DCGIEB<BBBDDDGD@@FGC<BFFCHGEIIFGHDHB?6>B>;CCCC5>?;<8@3>AC>@CACCCCBBBBB??C
@3MY
AAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGGGACACCCTCAGGGGGGCAGCATTCTTGGGCAGGGGGATCAAATAGTCCTCTTTCATTT
+
BBCFDEFFHHHHGHHJJJJJJJJJJJJJJJJJJJJJIIIJJJ:',,(,5&(((+388B3&&&(((+(+(+(((+)55>&05<((+((+((4(+((+(+4(+
@3MZ
CTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGC
+
CCCFFFFFFFHHHJJJIIJIJJJJJGIIJJJIJJJJJFHIJJIJJHIJJJJJJJHHFFFDDDDDDDDDDDDDDDFDEDDEDDDDBDDDDDDDDDDDDDDDD
@3N0
GACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATG
+
C@@FFDADFFFBDAHGIIIIIBHHCHGGCGFGEHGGIICG8BBBFGDGHIIIIFGEGIHGGIHHIIEHHGFHGFFFF6@CECCCCCCC?BBCCCBC?@C
@3N1
CCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTT
+
??@DDA?DDBC??:ABFD::?AA2A9A9<C::?9:**?:C?F9D;:D?@)090/*?DFDFBBFAFF;=8=EE@;7@DE>.?=C?;.).;@;(.66ADF;B@
@3N2
AGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTT
+
@@?DFEFFBFFHHIHIGHECIHHIIGIEIIGIGIGGFFHEIDDEHIGGHEHHHGGIGGICCGIIGEHIGADEEEE;AE?CB@@?BECC@@8=?@CCCDC:>
@3N3
GGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJGIJJJJJJHHHHHHFFD=@DD@CDDEDDDDDDDDDDDDD
@3N4
TCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
@<@D=@ADH>DHD@GGEBACF<?DD9:BD9BB6BDG;FF>FCECBB;<5@@7=A?>B3;@A?8;9=C>::>><>58>AAA>><AC?ACCCCB@>B339>C:
@3N5
CTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGCAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGC
+
@@@DDDB;D<2ADGGIIAEH@DHHHEEHG?EHACFHI=FBBD:9F@BHGGICCD@C88=CHHGB';=B?;;?>>;,5>@C;>:A>@?B35<3:4?B?092:
@3N6
GGCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIGHHHFFFFDEEEEEEDDDDDDDDCDDBDDDDDDDDEDDDDDDDDDDDDDBDD<AD
@3N7
GCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJHIJJJJJJJJIJIJGIJJJJJJIJIHHHHHFFFFFFFEEEDEDDDDD
@3N8
CTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGTGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGC
+
?@=D?DDDFFAF?:A:CAB:3CF6:F@D:@?GI7@07-7C8=F7.@E;=..-(.;BD;B76.6635=;;;55:@B?/8<0:(+90+<50@:4?839B9503
@3N9
GGACTTAAGCTATAGCTTGCTGGGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCG
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJGIJJJJJJJJIJHIIJIIIIHGGHHHFFFFFFEDDDDDDDDDDDDDDDDDDEDD
@3NA
ACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGT
+
@@@FDDFFHHFAFFHIIJJJJJGHIICFHIJJJJJJICGHHICFHIJIIIJBGIJJJJIJJGJJIHHGGGFFFFFDCEEDEEEEDACA@@?BCDCCDDCDA
@3NB
GGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATT
+
@@CFFFFFGHHHGIIIEGHIIGHIJJJJJJJIJJIJJIJGGHHGIIGJJJJJH7?EEFFFFFFEDDDDDDDDDDDDDDDDBBD<ACCBDDDCDDDDDDDCC
@3NC
TCTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCTTTATCTTTTTCATTTTCCATATATTCACGAACCTGATCCACATGAGTTGAATAAACC
+
@@@DDFFFGHHHFGGIIEHGFHIHGGHJIGIJGGIJJI@GIIJIIIEIIHIHHIJJHHIEIGCHEHIJJDDAHIEEFHADE>BFCEAEEEEDDDECCCC
@3ND
GTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTAT
+
C@@FFFF:CFHHHJJJJJJIJJJJJJJJJJJJIIJJIJJJJJJGIIIJJJIJJJHHHHHHHFFFFFFEDEEEEEDCDEEDDDDDDDDDDDDDCBBBADE
@3NE
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGG
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJIIJJIJHIGHIJJJJJJIIJDFHJJIGIHHIIIJJJIJJJJJGIHGBEDEECDCDDDDDDCDDDDDDCDDCDD
@3NF
GTCACGATCTCCCACAGCAGGACACCAAAAGACCATACATCACTTTGCGTGGTGTAGATATGATCAAAAAGGGATTCAATTGCCATCCATTTAACTGGAAT
+
CCCFFFFFHGHHHJJJJJJJJJJGIJJJJJJJJJJJJJIJJJIJJJJJIHIJ@GHIJJJHHHHHHHFFFFDDDDDDDDEEEDDDDDDDDDFEEEDDDDDDD
@3NG
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGG
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJIJJJJJIHIIIIJIJJJJJJIIJIJJJJIIJJJJHIJIHHHFFFFFFEFEEEEDDDBBDCDDCDDCDDDDDDD
@3NH
GTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGC
+
<@@A=BDDA:AFFI:EE@>?FDGFA?D>)9BB9DDFGE@*9BD(8BFDF@77.7)=@77??EE?DDDD@@>6>6;A5@5@ABB@:@BBBABB:@@:9?BD>
@3NI
CCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGG
+
CCCFFFFFHHHHGJJJJJJJIJJJJJIJJJJJJJJJJJJIIIIHHHFFDDDDDDDDDDDEEDDDDDDDDDDDDDDDDBBDDDDDBDDDDDDDDDD@DDDD
@3NJ
GTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTG
+
@@@DDDDDHBHDDGHIBI?CCAEHIIIDGACFGGGEGHGGGGGGAHGID=CGCGGGFHIIIIIAG@A=CCHEHEBECC6>@?CDCCBBBBB@CC@AC>AC>
@3NK
AGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
C@CFFFFFHHHHHJJJJHIJJJJJJJJJIIJJJJJJJJJJJJJJJJJIJJJJIJJJJJJHHGHHFFFFEEEEDEDDD;@DBDDDDCDDDDDDDDDDDDDDD
@3NL
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCG
+
CC@FFFFFHHHHHJJIGIIIJHJJIIIIIJJJJJJIFHJIIIIIGIJJJHIJIJIJJJJJJJIJIJJJI@EHHEHFEFFFFDEEEEEECDCCDDDDDDDDB
@3NM
CACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAA
+
@@@DDBEDD;DDFGDDF:FEBHIDGIBGHBFF@GGCHGDFGEGIGFGCFHIGEHEDCCCCAACCCC<5>>ACCCCCAC:?>?9AC@A>@@@ACCCCC@BB
@3NN
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
?@@FAADAHHHGHIIBFHIDHGDDC?HGEHIIIBFFHD;?FHGIIGHDAFIEHEGGIFACEEEFDDDEFECECCCA@BBD:B?>@CAC>>4:48:>C@>A
@3NO
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCG
+
C@@FFFDFHHFHHIEIJIJJIHEGHIGIGHJJJJIIFHJIJIIIIJJJGIJIJIGEGIJJIIIJIJIJJ7@BHEHF?CEBDEEECECECCDDBBBDDDDDD
@3NP
GCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGCTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGG
+
=@<DAD::2C?<C?A?FGBFGFB=HCEEBDCEEAGFFBFA??:?:BBDDD*9?B?D@@FF1@(.7=@6.7(37;BDDEDABC>AAA>AA>;A:;588((3?
@3NQ
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
CCCFFFFFHHHHHJJJJJGHGIJIIJJHHIIFIGJJJJJIIJJJIIIIIJJIJJJJIJJJJHHHHHHFFFEECDCDDDDDDDEDEDDDDDDDDDDDDDDDA
@3NR
GTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTG
+
@@?DDFDFHGHHHIHIJJDFHIIJJIJJJ?DGDHHGCGHJIJJJJGHIIDHIIJIJDHIGGGIJJJJJGGGGGDDFDDAEBBDCCDDDDDBCDDDDCDDEC
@3NS
CGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCA
+
CCCFFFFFHHHHHJJJJJJIJJIJIIJJJJJJJJJJJIJJJJJJJJJJJJIJFGIJHFCBDDDDDDDDDDDDDDDDBBDDDDDEEDDDDDDDDDDDDEDD
@3NT
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGG
+
CCCFFFFFHGFFFIGIJIJJHIIJIIJIIJIJJIJIIIGFGGGBFCHGFHGGJCGHJJIEHEFEFFEFDDDECEEDDCDDCDCDBCC@CCCACCCCDC>?B
@3NU
GTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGT
+
@BCFFFFFGGHHFIGIJJIGIJJJIHIIIID<AFGCBFHIIGIGGGIJIIIGHJJBFGHJHFFE?CFF>BBBD>CCCCDCCDCCCDDDDCDDDCDCCD@D5
@3NV
GTTTCTTTATGTTATAACATGTCTGAGTGTCCTAATTAAAATCTATTAAACTAACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCC
+
CCCFFDDDFHBDFGGDGHHHJFEIEGIHGCEEHHEGIGGIJIIGEIIIIIHIJIGGHCHG>EFHEEFIJIEHGEHHAHEGGGIHIECEEEEBDDDCCAC
@3NW
TCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGT
+
@BCFFEFFHHHHFHJJHIJJJJJGHIJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEEDDDDDEDDDDDDDDDDDDDDDDDDDDDDDC
@3NX
GCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
8?@;;BBDHF>FDD>A??FG>@>GBHHG@F9EFGFEHCBGH<DFF=AF;F3B=B8)=CH@))/7774;)=)7?EAC)?C;@:;6.;=@;;;@C>A3::>C
@3NY
TCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGG
+
CCCFFFFFHHHHHIJIJEGHHGIJJJJIIJJJJJFGIJFIIJ?FGGHIIJJJJFHIJHGHHHHHFFFFDDEEEDD@@BDDDDDDDD>ACDDDD
@3NZ
GGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATG
+
@?@FDDFFHDHBHHBHIIEEHHGIFGFHECGHIIH<CGBDHGIHIIIIBH<FEEHIGHIIIIIGGIIHHHGHEDDDCDDBC?B9<?ACCDDD?CCCDA?@C
@3O0
CATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGAT
+
CCCFFFFDFHHHHJJJJJJJJGIJJJIIIIJJIJJJIJJJHIJFGHJJIJJJJJJHHHFFDDDDDD@CCCDD?B9ACDCDACDCDDEDDDDDDDDDDEDCD
@3O1
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CC@FFFFDHHGHABFHIJJGIHIGIAEFCGHDBFHGHGIJEHIFEHIIJIIJIIJIFHHFFFDECEEECDDCDDDBDDDDDDEAACDDDD>?CBCCDACBB
@3O2
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CBBFFFFFHHHHHJJJJJFHIJGHIJJIJFHJJJJIJJJJJJJJJJJIJJJIJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDFDDDDDDDDDDDDDDDDDD
@3O3
AGTCTGAGTAAGGATAAAGTTCTGAGTTTGAGAGGGCTCAGCTGACCCCCCTTCTGTCTTGACTTTGACAATGACCTTGCCAGCCCCAGCCCCACTGAGGC
+
B@?DFFDEAFFFGJJJJJIJIJJIIICHIIHIGIIIIJIJEIIIIIJJIGGGGGDHHIJJIIHHHHEHFFFFFFEECE@ACDDDDBDDDDDDDDDDCDCDD
@3O4
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@@CFFFFFHHHHHJGHIIJIJJGGHIIJJIJIIJIJJJJHIIICHIIBFHIIJJJJJJCGHHHEHDFFFFDEDDEDDDDD;=BDDCDDDDB:ACDDDDDD
@3O5
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CCCFFFFFHHHHHJIHGHJJHIIIJJJJJJJIJIJJJJJJJJJJJJJJJIIJJIJJJIJIHHAEEFFFFFFFEEEECDDDDDCDDDDDDDDDDDDDDD<BD
@3O6
CGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
?@;D;D?BFHFFDCA:ACFG:CG@@@GHIICCHGEGHGIICHIIBGD?88=CFBF@>A@A@>>CHAEEHHD>;;?@;CB?@>?BB(88;BBBB@A>C(>AA
@3O7
GTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGAAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGAC
+
?:?DDDDD?C??3<<ACC+3:<+222AEFE<4??9CC<8)0B?9?BED<9?*??CCC<=@)8C;7==@7==7=CCA:A?>?@65(65=?;=::558<>:
@3O8
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
BCBFFFFFHHHFHIJIIJJJJJJJIJJJJJIJJJJJJJJJJHIJJJJJJJJJIIJJIIJJJJJJJJJJJJJ@BEBEFEFEEECEEEEEDCDDACBDDDDDD
@3O9
CGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFDFDDHHDFHIGE@?FEHGEHIJIJIIIDHHIJIIJJJGIIIEHIJGHGIIIJJGIIIHHGHFFFEFFEEEECC5@CB@C@?5:<@ACDDDDD2?C
@3OA
CATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTC
+
@@@DDDD:CFDHDH@DFH@CEE@HCHIIIGGAGGE:6D3@:DGE<FEGBB<@5C@CDEECC@D>ACCBB?B09050::@C@CA<CCC>@CCBBBB>@508
@3OB
CCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATAC
+
CCCFFFFFHHHHHJJJIJIJJIJJJJJIIJJJJJJJIJJIJJJJJJJJJJJJJDGHIJIIJJIJIIJJJJJJJJJHHHHHHFFFFFFEEEEEEDDDEDDEE
@3OC
GTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGC
+
@@@FFFDFHHGDF@@DHIIGCGGICFHIGGEGDEDFFHGIIIGGGH=CFGCGI>EGIIIHHGHGEFFFEECEEACCCCCCEFC@CCCCCC?<:@CCCCCDC
@3OD
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJHIJJJJJJJJJJIJJJIJJJJJIJIJJJJJHHHFFFFFFDEEEEEDDDDDDDEEFEDDDDDDDDDDDDDDDDDDDD
@3OE
AGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
@B@DDEFFHHHGHJIJJJIIJIIJJJJJJJJJIJJIIIIGIJJJJIJIIJGHIIGIJJGJDHGJIJGHHHHFFFFFFCCCCBDDDD<@B8?B9?CDDDC
@3OF
CGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTGTCCCC
+
:?????8ABFDFF@@F3C@:C3A8?9EF:CB<BGCCDDDFDEB@FFFII;@CCFFIIF7AA862;?C==>=BBA<(5@A<A@B@AABBAABA>8?B98ABB
@3OG
TTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTAT
+
CCCFFFFFHHHH4EHIJJJJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIJJIIJJJJJJJJJJJJIJJHHHHHHHHFFFFFEEEEEEEDDF
@3OH
AATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCC
+
?@@DBDDDFDA?DBEFE:CGFCH9FB1??F6AFE4@DEF92.=?BDCCC;;'98895>BBBBB?BAA(:A@++4:4@4>:3(:?>93288??BAB>@AAB>
@3OI
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGG
+
CCCFFFFFHGHHHJJEEHIJIJIJHIGGIFHIIEHIJIJJJJGIGGGJGEHIIGGIIJJJIFHHHHFFFDD@CEEECCCCCDDCBCDCCCDCD9@>CDCCD
@3OJ
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
???;:DD>A?CDBEE:A?FI9BF:<2<CAED?)0?@DDD??CA8=86;;@@DD;=C?A>@;7;;@AA>;A>>?=>>>A>AAA>>>>:(:>>A>AAA>>AA>
@3OK
CTGGCATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGT
+
@@@DFDEDHHHFGG@E@AACEGIIIHEHEIIGACEDGGDHBFBFHGIDHBBGGID)?A@@CGIDEHHGGGEEEHBA?@B?7A>C??BB9<5>CCCCCCCA
@3OL
GCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCAT
+
@CCFFFFFHFDHHJJJIGGIJJJJHIIJJJJJIJJJGGJIJIJJIJIJJJJJIJJGDHIIGIIJJJJEIJJEHHJIIIJJHGHHFFFFFFEEDEDEEDBDD
@3OM
CTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATT
+
?@@FFFFFHDHDHIIIIDGGIIJJJJJGGIIJGGADHIGIIGIGIJJIIIHIJJIJFHJGIIJJJHHGEHFFFF;?B;ADCDDDCACDDC@CCDDDDBACD
@3ON
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHHHHHJJJJGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3OO
CTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGT
+
CCCFFEFFHHHHHJJJJJJJJJJJJJJJJJJJJIJJJJJJJFHIJJJJGIIJGIJJJJJIJJJIJJ?CHGHFFFFFFEDEDDCDDDEFDDDDDDDDCDEDA
@3OP
CTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAA
+
@@?DDD?DFHFFFHHGIIGIIC<?FH<FEC>EHEGHGGHFHIIEHGGG@BDGIAEDGEAHB48BHIIGHG>F@ADGHGHIIIFHCFEEEDEEDCCACCCC
@3OQ
GCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATC
+
@@@DDFFFHFHHFGGIGIIFJHCHICHIHGIEEGGHIIH@?DFHIGDFGIIJJJIIIID@FHHGIIGGIJGGHHIIIHCE=AEEHFE;BCECEEEEECDDC
@3OR
GCCGCCTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACT
+
CCCFFFFFHHHHHJEFGHEHIIIJJJJJJJJJIJIIGIHHIGIJGIIIEHGHEHEHGGIJJJIHIEHHHHFFDFEDECEEEDC@CDDCDCDDBBDDDCDDC
@3OS
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHHHGIJJJJJJHIJJJIIHHIIJJJJJJJII>GHGIGIJJIGGIGHCHGFFDDDDDDCCCDDDDDDDDDCDDDDDCDDCCDDDDDDDDDDDD
@3OT
CCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAAT
+
@@@FFFFFHHHHGJJIJJGGIIJ?EFGGGHIIJIJJJICGEHGGIJGI;D@DHIHGFFDDEDDDDCCCCEDCDACD@DC@DECDDC@BDDDDDD@BDDDDD
@3OU
GCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAAT
+
@@@FFFFFHHHHHIII<EHI>HFIIIIIICGEHGGIIIHIIGHIGGDGICCHGHEIIIIIIGIDHGGIIIIGIIHGGEEEHFFFFDDCECCEBCCCCCCC?
@3OV
CCATCATCATAATGGCTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGA
+
CCCFFFFFHHHHHJJJJJJJIJIHGIJIIJJIJJGGIIIGIJJJIIJIJIHFEGGIIJJJIGIIGGIJIJJJIJJJHHFHFFFFEEAEEEDEDDCCDDDD
@3OW
CCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGG
+
@@@FDFFDHHHHHGIIIJJJHJJJIJJJJJJJIJIIJJJJJJIGJJJJJJJHEIJIJJJIIIIIIIHGIHIFGIJGIIJHIGHGEEFFFEDEDEDDBDDCD
@3OX
GCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGC
+
CCCFFFFFHHHHHIJIIJJIIIIJJJJIIJFGHHIJJJJJJJJIJFGIIJJJIJJJJJJJGGIIJJIJJJJIJIHHHHHFFFFFEDDECDABDBADDDDC
@3OY
GTCAACTCTAAAAATTCTCTCATTGTCTCGTCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGC
+
@@@DDDDDFAFDD<FBBFCHGGHHIHECGBGHGAGGHGHGGHG<BEGGHI9BF0BFCHDH@DHGC<<;@FGG==C=EHHH?EEFF7;?@>@C;AACD;(5=
@3OZ
GGACCATAAAACGTTGCCATCCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGAC
+
@@@DDDDFFHHHGHIHFGFHIIJEEHIJJJJJGJGBHIJJFDHIGIIJIIGIIIJIIGFHHFFDFDFFEEECACCCCD@CCDCDDD@@BCDDDCDDDDDD
@3P0
CCACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAG
+
CCCDFDFFDHGHHJIGEHIEIJ>HHIIGIGAGIIIGGGIEGFIHGIGIIHHGIIIJJJJB?FEIHIFHHIGI@EH@EE=CHCDFDFEC@@ACCDDDDCC
@3P1
CATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGG
+
B@CFDFFFHGHHGIIJJJJJIJJJIHGHGJJJJJIIIJFGIJJJJJJJJIJJJJJJJJJJIJJIJJHHHCFFDFFEEDEEDDDDCDDDCCBD5?BDDDDB
@3P2
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@=@DDDFFDB?FFHGGE:FF>BFFDHGIGBFGIICBGFEBF>FECHIEEGGGCHHHEAEDDFFEECCCEEDDDDCACCCDDCDCCDDDDCCBBDDDDDDCC
@3P3
ATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCC
+
@@CDAEDDDDHHHIEG>9IHIIEEH1CF<C?CFEIDEGHBAD>FA?F>DFCCEGG=FE@CHG;DEFHHHHCDDDDDBCDCDECCA@=35>>@DDC5>ADA
@3P4
TAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJHIJIJJJJJJJJHIJHHHHHFDFFFFEEEEEDDCCDEEDDDDDDDDDDEDDDDDDDDDDE
@3P5
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTG
+
@CCDFFFFHHH@FHIJFGGCHHHIIHIJJIJIJJIJJIJJJJJJJIJIJJJJIJJIJIIIHHHHFFFCCEEECEEEDECDDDDDDDDCCDCDDDDDDBDCD
@3P6
CTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTG
+
@@@BDDDDFBDHHIGI?GIIII@GIGHEGGGH@BGHGCHGI)?DH@FGIIGGGGEBHCD?BBBBC@ACCCCCCCCCCCCCC<<CCAC>>A@CDCCCCCCC:
@3P7
CGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGAC
+
@CCFFFFFHHHHHJJJJJJIJJJIJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIHHHHFFDDDEDDDEDDDDDDDBDBDDDDDDD
@3P8
GTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGG
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJFHJJJJJJJJJJJIJIIFDDDDDDEEDDCDDDEDDDD>BDDDDDDDEDDED@CDDDDDDDDDDDDDCDDD
@3P9
GTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
BB@FFFFFHHHHHJJJJJJJJJJIJJJJIIJJGGHJJHJJIJJJJIJIJJJIJJJJJJJJHHHHFFFFFFEEEDDDDBDACDDDDDDDDDDDDCDDDDDDD
@3PA
CGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTC
+
@@@FFDFDHGGHGIIGHJGHDHIIHGGIIIIJIJJJIJDHGHHHHEHFEFDD?DDDDDDDDCDDDCCCCCCDDDDCDDDDCCDCDCDDDCCCED?CDCD?@
@3PB
TCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGT
+
@@@DDDFFHHHGGJJGIJIGIAFHIJJIJJJJIJJJJJGIJJIIIGGJJHIBGHIIIIIGJJJJHJGHHHEFFFFFFFFACEEEEECDDDCCCCDC@ADD5
@3PC
GTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTT
+
C@CFFFFFHHHDHIJJJIJJFIIJJJIJJIJJJIIGGGIJGIJJJJIJJJIJJJJJJJIIAFIIJIGIJGIGGCGIJJEGHHIIIHHCEEHHFFFFFFFDD
@3PD
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTG
+
@@??DEADAACFB<EFEHHG:@F@F=CHIIACEHIEHAHD>AACCC@CC@A5ACACCCCECACACCCA::>A@AC?<<8AC@@>:4@>><?<<?A<:C4>
@3PE
AGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTTTAGTTACTCTGTCCATATCCT
+
@@CDFFFFHHHF<EFHFFGI<AFHIGHGIIJ:CGHGHIIIEGIJJIIIIJIJJAFHIJIGHFHG?CDFFFEDCBDDDDDEDCDCDD>CCCCDDCDEDDCDE
@3PF
GTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCCCCCGCCATGAGCTCCAGCAGGATGAACC
+
??8BD8B?BDDDBEDD8+<1C+CED>?@DB?D0?'@;:84'3'078(+(358&)&+8<82<3:>3><3+:>:9>?5;-;583++:>4>:3(92<8:4>:A<
@3PG
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCT
+
@@<D;DDDAFFDHIFIIGIGGHGIIDGEGHFGHEDGGGGCFGGGIIGEGCHC@@FEHI5:95;;@CAC=B8??:@@A::A>ACCCBA@5<0<CCCCACCCC
@3PH
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCT
+
CCCFFFFFHGHHHJJJJJJJJIIJJJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJGHIJJIJIJIIIFIHHHEHCEFEFFBDEEDEEEDDDDEDDD?BDDC
@3PI
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCT
+
+=;DDD?AAAF<DFB?EFE@:?CAAEHEHIDH<@F:D?9?D?:@6D;8;?BFFBFDEAF@;.8=CE4.=77?AEFDABDD@377;A@;?B@,3?A@A@:>@
@3PJ
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCT
+
@@;DDEFFFHHGHIJIJJGIGIFHGIIJIJEHIHIJFGIJJJGGJHJJJJIHHIJGEHIGIJGIJIIJDHHHAEFF=CCC@CCDDDD?ACDCCDCDCDDBC
@3PK
TTTAAATTGCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTCCAAGTGAGGAGGC
+
CCCFFFFFHHHHHJJJJJJIIJJJJJJJJJIIGJJJJJJJJIIIIJJJHIIIJIIIIJJJJJJJJJJJJIJIJJJJIJIJJIIHGHHHFFFFFFEEEECBD
@3PL
ATGGGGAGGCGGGGGCGGCTGCTGGGGCACAGGAGCCGGGGCCTGCTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCC
+
CC@FFFFFHHHHHIFB?BB83?@ACDDDDDCCDBBDD6BDDBDBB?@CDCDACCCAA:@CC3>B5?::>@CCC+>>ACCAC>@>@>ACD<<@D9>BD098?
@3PM
GCCTGCTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTC
+
@@@DFFDDBFFFHDIIJGIHI<FGFGHIECIII*CFHGGHJEIJIEIIIEIIIDGEG@AHFHFFFEEEEDEDDDCCCAD=@@DD>CDACDD:AC@?B@@DD
@3PN
CGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCG
+
@@@A?DEDHHFDBHEGGGBDACH@FCE>?F<FDHIB??FHIGI@B?:DG<BB?DFDHGHHGEBFDEG=@@FD>>CEC>DAA?ECEAADFDBCBCEECA>3,
@3PO
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@@@FFFFFHHDFHJJJJJIGHIEHIJIIGJJIIJIJIJJIJIIHHJJIJJGIIGIGHFHFHCED@?@CCEDC>BDDCDDEEDDDDDCDDDD:@CBBDDDDD
@3PP
CGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTT
+
<@CDDFFFHHGHHIIJJJJJJIIIJJJJJJIGIIJIJJHHADFFFFEEEEECEDCCDDDDDDDDDDDDDCDDD>@D+<CADDDDDBCDDDDDDDDDBCDCC
@3PQ
TGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCCCCAGTAAGAAC
+
;?<DDD;?==CFF<FGIBFFII<4+C?:CD?A9<2CG*:*)):?@FB9??99DB9B@F(BF>BFFGBGF@CF@7=D)=7=?ADD?;;;(;@C;;;;;5>B
@3PR
AACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGTAATGC
+
?@@FBD?@CDCCFGFHGDDEGEFHIIIEGF??@BBAGEECHIGICHEHGDEE==D=D@B>ADBBECCAD@@BD;3>@@CCCAAB899@B@CCC?8>>A>@
@3PS
TGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATAT
+
CC@FFFFFHHGHHJJJJJJJJIJJJJJJJJJIIJIGGGHJJJJJIJJJJJJIIJJIJJJJJJJJJHHHGHFFFFF@>BDDDDDDDDCDDDDDDDDDDDDD
@3PT
CTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTC
+
?@@FDBEDHFFHHIGIGIAFEBFGEHGGGGHHIIHIIGIIIIIIIG>DGHIGEBDDDFDGHCGGIIIIIGHHHHHHFFFCBDCEEBC?CCB;@@CCDCBDD
@3PU
TTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGGACATAGGACGTCCTTCCCTTG
+
?<?DBD?DBB?D=22<<CC<C<A@E4?<?CDB9D>@DD<00)086?.8BADI/557===AAA).;)6;@6@A55;???=',82>4::A>9)0<<>>+9:43
@3PV
GGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAG
+
BBB=DDFFHHHHHJJJJJJJJJJJJJGIJGHIIIJJJIJIJJFHIHIJJJIIJHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3PW
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
BCCFFFFFHHHHHIJIJJGHHIJHHJJIHIIJFHIJIGIIJIJFIIJIJJJIIIIIDGHIJEHHHGHFFFDEDDCCCDDDDCDCDDCDDDDDCCDDDDDDD
@3PX
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTG
+
CCCFFFFFHHHHHJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHHHHF@BDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3PY
GGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCT
+
?;?=:+A+24?<A:A<BE9CFFCCEBCB>E>EE<BBDECDEE;?DDADDDI?@DIEDAED<BCCC4B@CEDCCDC7A==CC?7=>@DD;;@AA@AAAAAAA
@3PZ
CCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGC
+
@@@FDFDDHBHFHJIDHGIJFHGHGIIGHEIHJGIGGCC<@DDH?FHI>G>B@D??8E=C@A;C@B@@EC'9'>AC>5?CCC@@CCCC??ACCBBB@<3>>
@3Q0
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
@CCFFEFFFDDDFHFGGIJIJJJGIIJIJIIJJGHIJJJJJJJJJJJJIJJCHIIGAGHHHHHFFFFFAEEEEDA@CC@@CCCDD?BBD9ACDDCCDCDDC
@3Q1
CTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTT
+
?@@ABDD;CA,,A?2A?A4AH<?A;<CF32AE?*?E<C9<:CDFF9<DC9))9*?()8...))87C8@<8/A<(;<;.658((-((5(5>35>B:>A4:4:
@3Q2
GTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACT
+
8:?BDDDDHDFADFG@FDAGFIBBA?FGGFFCEFGF?DHCFDFGFG??DDGIGICBFFG<<=@@CEAEED>DCEH>AB@@DDDBCCCCBB=BC@CACCCC:
@3Q3
GGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGT
+
B@CBDFFFHHHGHJCGHJJIJIJJJJJJJJJJJJJJHIJJJJJJJJJDHIJJJJJJJJJJJHHHGHHHFFFFFFEEEDEEEDEEDDDDDDDDDDDDCDDD
@3Q4
CTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTC
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGFHIJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFFEEDEEEEEED
@3Q5
GTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACT
+
CBCFFFFFHHFHHJJJJJJJJJJJJJJJJJJJJJGHIIJJJJJJJJJJJHHHHHHFFFDDDDDDDDEDDDDDDDDDDDDEDDDDBDDDDDDDDDDDDDDDD
@3Q6
CAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGG
+
CCCFFFFFHHHHHJJIJJIJJJJJJJIJGIIJJIJJJJJJJIJJGIJJJJIJJJJJJJIGHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEDDDDDDC
@3Q7
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCCFFFFFHHHHHJHGIEGIGHJJIIJJJJJJJJGFGHIJJJJJJJIJJIJJJJJIJJJJJIIJIIIJHHHFDDDDDDDDDDDCCDEDEEEDDDDCDDD
@3Q8
AAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTG
+
@@@DDFFFFBDFFEIJGGCFFDHIJGIIJJIEECFBG@HIGIFEAGGCHHGIBFBBFGCDGGG4A@AHDHGEEHCEABDCDFCEE@>BCCDCCDCCDCBCA
@3Q9
AGTCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATC
+
BCBFFFFFHHHHHJJJCGIHHJJIIJJJJJJJJJJJJHGIJIJIJIJJJBEHFFFFFFEECFEEEDDDDDDDDDDDDDDDDDDDDDDDEED@CDDDDEEEE
@3QA
TTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTGTCTGACAAGAAAAGCTAAAGAGAGTTCTTCAATCT
+
@@@DFFFFFHFFHIGIIGCHHGIEBDEGJGHICHHJGII@FHIGIIGGHBHIJJIIJICGCGFHFEHDDCF@DECCEEDDBCDDCDCCCB>CCDDCDDCCC
@3QB
GGCATAGTTCAGGCCTTCAGGCTTGCCAGAAGGGCAGTAAGCCACTTGTTTTTCTTGGCAGAAATCTTTGTCTGCATGTGGTTCCTTCTCTTCTTTCCTC
+
CCCFFFFBFFHADEGIBEGEEBGHGIIGCCGFAGIEHGGHGGIIIJJJHGIIJGGGIGGGEEGHIHGFHEEEHFFFEDDBEEDDEDDDDCCDDDDDDDDD
@3QC
TGCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGC
+
CCCFFFFFHHHHHJJJJJIIJHIJJJJJJJJJJJJJJJJJIIIJIJHHFFFFFDDDEDD@CBDDDDDDDEEEDDDDDDDCDD9@D<CDDDDDDDDDDDDDD
@3QD
CCCAAGAGTGAAACTCCATCTCAAAAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTC
+
CC@DFDBEHFHHHJGIJGIGIHIJIIIJJJIJGIIGIJGGGGGIGIJJJIIHHEHEFDDBABDDDDBDCCDDCCDBBCDDDEDDDDCCDDDD?ABDDDDDD
@3QE
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGT
+
@@@FDFDFFHHHGIGGIGEHGGIJJJJJJIJIJJGIGIIJIIIJJJIGIIGIIIJJJDDDDCCDCCC>CC@CBDDDCAA:@CDDDDDDDBCCDDDDDDDDC
@3QF
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTT
+
CCCFFFFFHHGHHJJIJJJJJJJJJJJHIJJIJJJJIJJHIJJJJEHJJJJJIJJJJJJHCEHHHFFFFFFEEEECEDDDDDDDDDFDDDCDDDEEDDDDD
@3QG
CACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCC
+
?@?DFADDBHFHDIFHGGBFIIEDHHEBHDDFHIHHIIIIGGGGIIIC?<FAF@FGFGFGEBCFGIID=C@FHCE@CG@D=A=CHHACFFFFBCECEAC
@3QH
TGTCGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTC
+
?@@DFDADBHFHHIJIEHHHDIIJIJFGIFHGGHIGIJFIJGEGEHEH<DB;FGCAFHGIJCAHCH9=ADF;BBBCEED@BDBBDDCCCCDDDDCCCDA>C
@3QI
CTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJHJJJJIJJJJJJJJJIIJJJJJJJJJJJJIJIJJJIJJJIHIJGHJJJJJJJJJJJIHHHHHFFFFFFFEEEE
@3QJ
TGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTG
+
CCCFFFFFHGHHHJIJJJJJJJJJIIJJJIJJJJJJJHHJJJIIIJIJJJJJJJJJJJCEHHHGHHFFFFFEEEEEDDDDBDDDEDDDCDDDEFDDDDDDD
@3QK
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@C@FFFFDGFFHHJJIGIJICGHHGGGEGHGIFEIJIGIGIGGIIIIJGHJJEGICHGCEHEGGI6@AECEHBDDBDFFDDD3;@B;CCDDDCCDDDBBDB
@3QL
NGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCC
+
#1:ADAAAD?FFBACE=?D@B>EAC>>AF<<99?DE:D>CD93?BDCAFBDF88.>=)8@@E;??;?DC@B@?@B@BB>@BB<<?@AABBAA>ADA>>:+4
@3QM
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFDFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJIJJJJJIJJJHHHHHFFF=@B?CDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3QN
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGT
+
BBBFFFFFG=<<ACGEEIIIJGJJJIIIJJJJJIJJJJJIGJJJJJIIHIJJIIJIJJHHHHHHFFFDDBDACCDDCBDDDDDDDEDDDCCCDDDEDCDD8
@3QO
CGCTGGAAGCTCTTCCCAGGGGCAAAGTGGAAGTTTCCGGCCACCTTATTGACTTCCAAGAAGCCATACACCTGGCAGCCTTCATTCTTCTGCTCCTGCAT
+
?=@B;8ABFDADFFAGEF<+<@?:?CG:19?F?:??BF))8@;7=BBF@;=FCFIEIED7AC7=BBBD;@AB>CBB9=;99A>5@@;>>>>>>A:>>>ABB
@3QP
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
CCCFFFFFHHHHHJHIJIJJJHHFHIFIIGIIJJIJIJFEFGGHIIFHGIHGIIGII@DHFGEHHEFFFFCDDDEDDDD=BDDDDDDDCD@CDDDDBDDDD
@3QQ
CGCAGGGCTCTGGACATTTTCTCATAGGTCATGTTTGTTCTGTTCTTATGGTTTCCCCACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTT
+
C@@FFFDDDGHHHJIJJJIIJJGIIJJGEDFHIIIJGJJJJIIJIJJIJJJ?FFGDGGIGHHCGGHGHAEHEFFFDCCDBDDDCCDDDCDDBDBDBDEEEE
@3QR
GGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCC
+
CCCFFFFFHFFHHIIJJJJJJJJJJJJJJJJHIJJJJJIJJJGIJJJJJJJJIJJJJJJJJJIHHHHHHHFFFFFFFEEEEEEDDDDDDDD?CDBDEDDDD
@3QS
GAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGC
+
@@@FDFFDDAFFBGGFHFHIGBGCGHI@GCHEGDAG=@DFIIGGIJGIJJDAA=DEHB66>@>CE@>@CCCCDCDDDDACD?CDDDBC@DDD<<@CDCC@@
@3QT
AGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJIIJJJHIJIIJJJJJIJGHHGHHHFFFFDDEEDDDEFDDDDDDDBDDDDD
@3QU
GGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCT
+
@@@=DDB?=CFCFFG?EGEF?FF<<?8EDE:8C?FG@:B9??BBFE??CFFI5@ECDADFCA;.;??;??B@19;>>5@5>A5@@@B@@A;@A@>>AAAA
@3QV
ATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATG
+
?@@;=DDDFFFHHIIIGGIGHIIIIIIIIIIIIIIEIIIFIIIIIIGHIIHHIIIFBHIIIIIIEGIIGIGGGIIIIIIIGGIGIG?EEEHHFEEFFD@DE
@3QW
GTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCT
+
B@@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJDGIIIJFGIJJJIJJJJJFHI@EHBDHHHGHHHFFFFEDEEEEDDDDDDDDDDDDDDDDDDDDC
@3QX
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
@<@FFDDDBDFFBIGIGHEHGGBHHHHGHGCBHGHIII:FHFEBDHIIE@B@=CF;C@;AEEDBFCECAD>>;;>;8;<?;@C?CDCCACA>BB?59<>5
@3QY
TGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTC
+
@@@DDDDDFABFFFGHII9FIH<?<EA<GBAGGD@DGHBGF@ACD?DGGIEDGHEAGIEHG@GCECEA?E@DDEDC;;;?=?B?CCC@CCDCCCCCCDCD:
@3QZ
CTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCT
+
@@CFDDDAAAFHDEHGGIBHCFEHEEHAHBEGHJDDHHEIAFHHIJIJEE=EEFFF>>;@;?ACA=>>CCACC?BD@@BB09<BDD9>BACCC<8AA8>>B
@3R0
GTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATT
+
?=?DBDDD>FHHF<BHHIGGAG<CDFF>HDABFBFGEDHGH@DG?FE:DFCH4DGEDBGGIIAB8?EH7@@DD<@AB=>;;;A>=?CCCCCCC>CDCC
@3R1
CGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGG
+
CCCFFFFFHHHHGGJIGHGIIJGFHHGGHIJJJJJJJJGIJIJIIJJJJGIIGJJGEHJJJJIIJIIGHJIIJHHHHHFFFDDCDDCCDCDDDD:@CEECC
@3R2
TGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCT
+
@@@DDFDDDDHDHEEBEGDFACEA@BEGDBFCHGBFHIDHC@GHICFG8B<DCGCHIEBFAFAEA-:B>,>>;ACC;A?A<83<<B@@>CABCCC@@C>?A
@3R3
AGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTA
+
@??DFDDDDDFBAFEEHG?HIDI<99F@DFDHHIHAGDEA9BDFFG7=C7C@9@.7.?EEEECDDD@BCCECC<?;?5;@CCCCCCCC>ACBBB59<B<@
@3R4
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGC
+
@@@?DFDDBBBBBDDCCA?CDDCDEDDDD@CCAABDDB?/@CDDDCCDDDCCCDCDDDDCD;07@C:A@@CCDD>@CB@C@CC>CDD@CCCCDDD3>ADDC
@3R5
AGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCC
+
CCCDFFDDHFHFHAEHHFFHJGGGHIJJGIGIGIJJIGGGIIJGICFHGGEEEEEDDFEBBDDDDDDDBBDB;;CDDD@BBBB@BDD?BDDCDAC>ACCCC
@3R6
TGCTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCC
+
@@@DDD8BAAB??GGE=?@H;FFHIHHCCBEA3?9CDFCFDDB?B?B3BG>B1B<FB8=@:CEC@D=CDCEFE9>@88>CC(53,(99<@@B88?>+428
@3R7
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGT
+
@@@FFFFBFD?DAFHGGGHGCFGIDG@FBFDHIEHEBF;F?F9DG=BBDBGDGAFGG.==?A=?EF@BC@DE(>A???@?A>CDCCCCCCCCCCCCCCAAC
@3R8
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTCTCCATAGGTTCCATAGCTTTGTTGC
+
CCCFFFFFHHHHHJJJJJIJIIJIJJJJJJJJJDGIIIIIJJHIJJJJIJJJJJ@EGIJHHHHHHFFFFDFEDDDDCDDDDDDDCDDDEEDDDDDDDDDDC
@3R9
TTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTGTCTGACAAGAAAAGCTAAAGAGAGTTCTTCAATCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJJIIJJJJJJJJJJJJJGHHHHEFFFFFEDEEEDDDDDDDDCDDDCDDEDDDDEDD
@3RA
CTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIHHIJJJJJJJJJJIIJJJJJJJJJJIJJJJJJJJJIIJJJJHHHHHFCFFDEEEECCDCCDDDDDDDDD
@3RB
GGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCT
+
CCCFFFFFHHHHHJJJJJIJHIIJJJJJJJJJFHIJJJJJJJJJIJJJJJJJHHHFFDDDDDDDDDDDDDDEEDCDDDDEEEEEDDDDDDDDDDDDDEEED
@3RC
AGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCTATTGTGTTTATATGCACATTGGG
+
@@@FFFDFHDHHHJGIIIJJGIIIIJGIIIJJJGIIIIHIIJGHHIIIIJIHJGIHGGGAGIGIIIIJIIHHAEEBHFFFDDCCECEEEEDEDCDDDCD
@3RD
GTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCTT
+
BBBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHHHHFFFFFFEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3RE
CTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTT
+
CCCFFFFFHHHHFHJJJJJJJJCHHJJJJJJJJJCGHIJJJJJBGIJJJJJJJJJJJJJJJJJJJHHHFFFFFFEEEEEEEEDDDDDDDDDDEDDFEDDDD
@3RF
GAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAAT
+
;@?BDDDDD6CBDG9FB9@6:FEGGGGGHI@FFEGGI>DGGGBEDDECCC?;@?BBCC5><@>@C@>CCCCCCACCC>ACCC9B?CBBBCC>CCCCCCCCE
@3RG
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@@DD8DD?BFBBEGGF<BBEGIEFGGCHIE;BGDGFHGEHIGGGEGIGIFIG<DHGIEA;AEE?D3;9;::>A@:@@<@<C:@>CCCCCC>:AA@0<?@C
@3RH
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@??DD?DDDAFD?CG<FHB<;AEC@CFDHEBFCFDHABG<G@??9BFHB??DBG>=8=@=FC@E@6=C?AHEEEB7?DBCCB'8;8,:9>@>A(:<<<BBB
@3RI
GGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGC
+
BC@DFFFFHHHHHJIJJJJJJJJJJJIHIIJJJIJJJJJIJJJJJIIIIJJJIJJIIHEH?CEFD<@BDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDC
@3RJ
ACTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTG
+
@@@DBDDDFFFFHIIIIIIGGIAHIIGGGIIIIIIIIIIIGIIIIFGHEHGIIIHFHFFFEEEEEECCCBB@BBBBBCCCCCCCCCCCCCCCCDCCCCC
@3RK
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
:?<A:B?DF?F3?D>8DFGE@GF7@BCFGG@@DF???B009?DE<FC38C98=FD=C77=FEEAEIBEE@7;;@DBA>;A(98,38>A>(:>>::3:4>A7
@3RL
CAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGG
+
CCCFFFBDHHDFHHGGEBIHIGBBHIIIJJFGGGGHGGHII@GDHGG;FHAGGGIIEECIEHFHHDED@CEDEEDDDD@CD@?@BD:@AABCBAACCB
@3RM
CAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCGAGTCCAATAATCTGCAGTGTGGAT
+
CCCFFFFFHHHHHJJJIIJIJJJJIJJJJJJJJJJGJJJJJJJIJIJIJHJJJJIIJJJJIGIJJJJJHHHHH'9AAECDDDDDEDCDDDDCDCDBCD
@3RN
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGAGGTCTGTGCATATCCTTGAGTGGGCTG
+
@@@DDFDFHHHHGHFDGIIGDHGIJJJJIGIIIJJHIIJJJJGBDGGIIJIIJIJGHIEIJIJIJJJJGEHGI.?E?CCE?CEEEDEEDDDDDDCCDDDCD
@3RO
CTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGC
+
@@@DDEFDFFFFH?FCFFFHHHIIEEHEIIGIH@CAFGFHIGIHEIIFFHIIIIIIIBHHIBBDHBDFGGHGIIGIIIEEHHHHFFDEFEEDCEE@CCCDD
@3RP
ATTCACGAACCTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTAC
+
CC@DF?DBD?DDFIGGGHGIEGGIIIIAEHHHIEDHIFHGIIGGHGH@DEG@CDHGHCHEGFCDDFF?BCE>CCCCCCCCCCCDA@CCCC@CACCDC44>
@3RQ
TATTATTCTGTATACAATATCACTACACATTTGTCTACAATGTCTAGGCATTTATACATAGAAAGGCTTGTAATACCAAAACCAAGAGCTAAGCATTTGTT
+
@@CFFFFFHHFHFJJJJJJJJJIIAHIJJJIJIHGCHIJIIIHHIJJJJIHIIJJIJIIJGIIIIHIJIJGGHJJIEHGGGIHHGED@DDCECEEEEDDCC
@3RR
GCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTGGGTCGTTGG
+
@C@FDB>DHDHDAEB?CFGIIGHGEHHGHIEEG?EGHFGHDFDDGGGEIHHIGGHIIICGHIIIIHCBCEDFBBBCEEEE>A>@=8@=<BBB<?8<@@BC<
@3RS
CTCCATCATCATAATGGCTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATC
+
?@@DDB?DDFFAHIE@CGHGEF@B:F@@F?EH999@FHAFHHHCGD9:B@>9?GHDA9@FGAC.8=CFFCFGGGIBA>>A>;BDCD;1ACCC>CCC;>;
@3RT
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@CCFFFFFHHHHHJJJJJJJIJIJJIJIJJFHIIJJIJJIIJIJIIIIFIIIJJIFGGIJIIIGIGJIJIIJHGHFHACEFDDDDDDDDCDDBDDDDDCDD
@3RU
GTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGG
+
BB@BDEFDHHHHHJGHIJJJIGIJIJJJIHJIIIIGIIJJJJJJJIGIGGGIGIIHHGG=FHIJGGGHHHFFFEFEDDCDDDDCDCDDDDDDDCEDDDCCB
@3RV
TGTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATC
+
??1A:BD?3CDA:CEEEBA@BCEI<FFA?<;C>A??E@E?D9DD?DD9::0:?D>BBDIBDCCCEA@@@CCD?@@A@AAAAAAA>>5>85<>A>>>A<:>>
@3RW
CTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTG
+
CCCFFFFFHHHHHJIIJJJIJJJJIJJIIIIIIJJIIIFHJJIJIIGHHHFFFFFDEEEEEEEEDDDDDBDDDDDDDDDDDDDDDDDDBDDDDDDDDD8A
@3RX
CCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCC
+
?@<DDFFFDD>BF@<CCGGIIIIIFIGIIEGGHG@?:CGBFHDBBBG?GGGHIIIIIIHIIIEGGHGIIIGIIIEHGIFEHGGHEDDFCCEDC>ACDCC
@3RY
TCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTG
+
CCCFFFFFHHGHGIIDIJJHIGIIJJJJJHIHIJJJJJJIIJIGIJJJICFGGGJJDHIIJIIGHHHGDFFFEFEEDD>@BCCCCDD:@CCCDDDDDDDDD
@3RZ
ATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGG
+
CCCFFFDFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJIJJJJJJJJJJHHHHFFFFFFEFEEEEEDDDD
@3S0
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGAAGGAGGGAAGGAT
+
@@@BAA>DH<FFHGIG18CCF>B@DGGE@?=:4C:?B4B4B*9BDEE?D88??CC4BBC8=)8=.;B<75(;;3?(;@@;3(;55@C((5<5<?>&+28(+
@3S1
GGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAAT
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIIJJJJJJJIJIIIJJJJJJJJJJJJJJJJJJIJJJJJJJJHHHHFFFFFEEEEEEEDDDDDDDEEDDE
@3S2
ATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGCGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCG
+
<@CDBDEFHFFBBHGEBDAFG<CEHCF@EHHCGAFF<ADFHHG?GHI;@A<AEH<CA>?>ACCE@AAC?B;;,:,:?ACBCB&5?CCCB9>CCDCCC44?
@3S3
TCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTG
+
@@@DDDD8DF?BA?@AFGECHEGDGFGHHGA<BDGHCGIIBFGGIG7CEHIG@EAAEEDEC7;A>AA>;;??C?C;>>CB?<8?ACCCC>@CCB88CCDCA
@3S4
GGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
@B@DFFFFHHHHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJIJJJIJJJJJJJJJIHHHHHHFFFFDDDDDDDDDDDDDCABDEDDDC
@3S5
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGAC
+
?@@D?DDA<FDHBDC3CC@FHHGI>?BGHGHHGHFHF9DHI>BFFCB?FHIHIG=@C>D@CEC:@GIE?AAED@BE9>C@CC:?BBBCBBB58<5<@<@@C
@3S6
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
?@@=ADDDHHFDHGIGG8GHHGG9AFC?CCFGEFHCEGIE@B??F1B=BBFHGIBG3@@8DHFHCA>?<<AABCCCC>@;>;-;ACCBCCCA:A5?CC>::
@3S7
CTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCAT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJJIJJJJJJIJIHI4@DEHHHHHFFFFFEEEEEEDEDDDDDDDDDDDDDDEE
@3S8
GCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTC
+
CCCFFFFDHHHHHJJJJJIJJJJJJJJJIIJHIIJHIJJJJJJJJJJJIJJJJJJJJIGGHIIJJIJJJJJJIJJGIJIHIJJJHHHHHHFFFFFFFDEEC
@3S9
AGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJFHIJIIJJJJJJJJJJJIJJJIJJJJJFHHIJJJJJIJJJJJJJJIHHHHHHHFFFFFFFEEEEEEDE
@3SA
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAAC
+
???DA@D?DFHHDFGIIIIIIGBEFHGGGEHI@GIGCB49?F@BBCFHHIGGEECG;DHFEEHHBDEBCACCCCCBACCCCCAC@@@ACC@@B&59>&:>:
@3SB
CGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCT
+
@CCFBDADHHHHHIIIGGHIJAFFHHHIIIGGGEGDDGGIJJHGHIFJIHHHGIJJEIGIIIIIIIDHHAAHEFFDCEEEDDDDDDDBDBCBDCDDECDDD
@3SC
CCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGAC
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJJIIJJJJJJJJJJJJHHHHHHFFFFFFEEECEEDDDD>BCDDDDDDDDDDDDDDDDDDDDDDD8?CD
@3SD
TGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGT
+
CCCFFFFFHHHHHJJHIJJJJJJJJJJDDDDDDDDDDCCDCDEEEDDDDCCDDBDDDDDDDDDEDDDDDCDDDDDEDDDDDD>BBDCDDDDDDD@CDDDD:
@3SE
CCATCTCATAAAAGATCATCCGGTCAAAGTTGCTGGAGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGG
+
@<@DDEFFHHHHHIJIFEEIGHGFDGGICCFECC>A):?BBFGGGIJIEIJCHIIIGECHGIIG;E==AEBDFFFEACCEBCCDCCCC@B@@CACCACCBD
@3SF
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
@@@DDD=DFBD?F3:?FC@GCBC9??FE@A?000@@8B4)).7-;5)@;7)7.7.-,995>C;AC;;?55A/82'0?::@::AC3(+(+44@C<8:3?:AC
@3SG
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
CCCFFFFFHHHHHJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHH=ADBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3SH
GTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACT
+
CBCFFFFFHHGHHJJJIJJJIJJJJJJJJJJIJJJJJJIIJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJHIEEHHEEDFFFFFECEEDEEDDDDEEDDDD
@3SI
CGGCTGTGTGTGTATAGAGCTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACAT
+
@@@DDD:?<DADB?CCGFI4AF?<F<>C?CDFGFBFFC9D<BGFDFFFFIIF@4C8':BBD@;BBA@AA>ABB@AB>AAB3>:AA???:@@AD3@:::?BB
@3SJ
CTGTTTTTCTGGGGACAGCAGATCTGCCAGAAATTGAGGGTGAATTACAGCCTCCACCTTGGAGACAAAGACCTTCTGAGAACACAGCTCATTGTTGTAGC
+
???DDDDDDDB?3C@8+AEBEE<<9AE33?BD@C<?9*)?)8)09*?*9?8..=;=C;(===;7)-7)=;7;7?:.>66.;;>A3;?233>AD(,52(++:
@3SK
AGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGAC
+
C@@FFFFFHHHFHIIJGGIGIGHIHIIJGHJIIHFFFECDDDDDDDDD9@DDDDBCDDDDDDD;BDDDDDCD9@ACEDDEDCDDCCCDDCBBDDDCDCC
@3SL
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAAC
+
=?@<4=DDFAFFFGIIGIIIIGGGIIGGEHGGCHGGEECGIGI@>FHCGHGCAGCGCGHFF@CEEC>>CACED@:??>@CDDCC>CACCCDDD50<B<:A>
@3SM
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
@@@DDFDFGHDHBEDB@FHIDEEGHCC@FHIGIGEGGGIIIIIIIDHIIIGIIIIIGIFEAEEFFFA@B8>CCCCC??@BBCCCCCCCCA@>AABBC@?@@
@3SN
CGGGGTTGGAAGCCTGCGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTG
+
@@@D@0<AFFBF<F>GHI@8)CG<?@FEHHBFBGHDEBCAA?B888?@B@8@05<59<<+:>3>@::C79>552(4938<??783@<>:9<-<>8<?<?(>
@3SO
GTCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGGGTGGGGGGGTTGGAGGGCCTCATTCC
+
@?@D?8DDDC;FFAG??8AFCFD*:1?BCCFE>4?D3B9B>DEFEDD@B4BD;BF55@@A=9CDD<BCCBBB35(5,,5<>B><)55&:(2098(8@@B>B
@3SP
TTCCAGTTGTGCCCGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJIJIIJJJJJJJJJIJJJJJJGIJJIHHHHHFFFFFFFEEEEEEEEDDDDDDDDDDD
@3SQ
GCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGC
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIGIJJDHIIJHHHHHGFFFFD=@DCFEDDDDDDDDDDDCDDDDDDDDD
@3SR
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJJIJJJJIJIIHIIJJJJJJJJJIJJFHHJIJJJ;CHHIJJJIJIGHHHHHHFFFFFDEDDDDDDDD?BBDDDDDDDDCDDDDDDDD
@3SS
GGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFFFFHDFHDFHHGHJJGGGHEHGGIIJJJJJIIGIGDGGHDHIFJJJJIGEE<;=EFHFFFCDCC6>>=CDCCCDCD?CDDDDBB?3>CCDD@>CC
@3ST
CTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCT
+
CCCFFFDAAFHFFHJJJI>HHIIIGHGHHHIJJGJHIJCHHGIEHIJJJIICHIJJJJIIIGIIGGIJJJJJJGGIIJIIIIIIGHGEHHHA>?B?BDDC
@3SU
CTTCTCTTCTTTCCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATAT
+
???D7DD4ACA?DEB?EB::333A@ECF<+9?9:4?E<@9)):):BD;D3((08;==;=AD;@77..@7=3).=.))77?;;>:;;A>A>3;=5;>>>;:A
@3SV
CCTCTGCATCTTCCTCCTCTTCCAAGGCCATGAGTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTTCTTCTTGCTCTAGCTCCTCAATTAAGGCCA
+
<?<BDDDDFHBH>FGD;FBHH4AD<EE<GA;CBF?<A)08?BDFHBFHHFDGCEGGAC@G)>=D@>AAE;?A;@>C>BC;>@;;35>3@CAA>:@CC29
@3SW
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHHHHJJJJJJJJJJIJIJJJIJJJJIGIIJJJJJGIJJJJJJJJJGFHEHIJJJJJJIJIHHHHHHHFFFFFFEEEEECEDDCDDDDDDBCA
@3SX
TTCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTGGGTGG
+
<@@FFFDDFHHHHHHGGGFHJCFCHEHCEBHHDBCGCIIGGIGCGG>GHHDIFCFHHGIGICHHJIHJJIHGBBDCBDD@BCCDD@?@BB9>ABCCDB?@B
@3SY
CCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCT
+
CCCFFFFFHHHHHIJJJIIIJJJIJJIIIJJJJJJJIIGIIJJJJJJJJJJHGFFFFFFEECEDDDDDCDDDDCDDDDDDDDDCCDCDDDDDDD9>B5@CD
@3SZ
AACAAATTGTACGAACACAAGACTTAAGAAATAAGAGCAGATGCTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCTTGGGGAAAGAGTGGTCTCT
+
CCCFFFFFGHHHHIJIJJJJIIIIJJJJJJJJJJJJJIIJIJJHIJJGIJJEHJJJGIIIJGJJJGJIGCHGHFFFFFD>CCEEEDBDDDDCD>ABCCCDD
@3T0
GCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCC
+
@@CFFFFFHHGHHJIIIIJJJGHGJDHIIIIJFHIIJJGIJJJGIJJJJJJJJHHHHHHFFFFFDDEEEDDDEDDDDCDDDDDDCEDDDDDDDDDD?DDDD
@3T1
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTAT
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJFGIHIJJJHHHFFFDEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3T2
GACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJIJHIJJJJGIIJJIIJJJJJJJJIJJJHHHHFFFFFFFEEEEDEDD
@3T3
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
=?;DD:2@@FHDFBGF><AFHDEHGGGIGBHEEH@F@AGGIBEGGBHHIIGIGFGF6A@A@@@EHAEF>?B@EDB@9;ACBCCBB,55<5>C?CBB8?A
@3T4
TTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCG
+
<?@BADDDDDF::ACGG<?BEG@HEHEHEHIEF=?BDDD8@FB;C;;A5@GCD@HEHHEED@DCCBCBBBC<;5:>>@@?B?<5<C<CCCCC:@CCCCCB
@3T5
TGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCT
+
?<+ADDADBFHFHGGIGEDHHHEGEGIJGFIIEHHIGIIGGIIIIJJIFHHG?FHGIJCCHIJJJ;AED=@CCDCC;ABA<@BBBDDDDDDDDDDDDCDDC
@3T6
GGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCT
+
CCCFFFFFGAHHGJJJIJIGHIJJIIGGIJJJJJJJIJJJIJJJEFHIGHIJJIJJHHHHAHFHFBDFFDEDBDDDCDDDDDD8?B?ACCDCCCCDDDDCC
@3T7
CGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACA
+
@@?DDFFFHGDFHGIJIJII@EEHGFHIJJJIGIJHIJJJGE:DDFHIIHIIIIEHIG@IIIGHIIBHIGHGFHHFHFFFFFFEEEECDCDDDDDDDEDD
@3T8
CTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCTTCTTCTGTCTCTCCTCGTCCT
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJJIGHJJJJJJJJJJJJJJJJJHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDB
@3T9
CGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGAAGCAGCCCCCTTCCGGCATGTAGGCCATGCT
+
CCCFFFFFDFHFHIJJIJIGGCEHGHHJIIJGHIHHIIJJIGBFGHIGGIGGIICFHHGEHFDCDD:>B++4:?9ABBBDBBDC><<>BA@@DCCDBDDDC
@3TA
CTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACC
+
;@=DDDFFHDFFFJJIIJJIGIEAGHCGIJIIGIJGGJIAGHHIGJJIICEHGGGIHHJICGGGHGGIIIIJFHHHDH?BBCDEED@>AACCCCDEDCAC
@3TB
CGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGT
+
@BCFDDFFGGHHHJJJJJJJJJJJJJJJJHIJIJJIIJHHHDFFFEEEEEEDDEDCDDDDDDDDDDDDD>9?BD9@D<ACDDDDDDDCDDDDDDDBDDDDC
@3TC
GCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCAC
+
?;8B1=BBDBDDDBAADEEEBAE<+<AAB<FAFICFFD<ECDDCEDDD:;(=)=A7@ACCE=ACCCE;A)77?.6;@66.;;.;>;???>ADAD>AA>?A?
@3TD
CGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTG
+
@@7DFFFFHHHHHJIJJJJJIGIIGIIIIJJJHGGIIJJIIGIGIIIGEGHIJHHIGGGGIEHGGHIJJI@EHFHF?CEDECCCEEDDDDDDDDDDDCCCC
@3TE
CTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCT
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJIJHHHFFFFEEEEECCDDDEDDDDDDDDDDDDEDDD
@3TF
TCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTAT
+
:?8AAA22A:C4CFEFEFB?3AEAIH4<3+2<422+2?EDG>E9F3CG@B@0?GAB4*098B<*9F84)8CC<7@;@..=77@@EE>.)=A>DB?BAC:A@
@3TG
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@?@DDBDDHHACFI<AFGG@GGFF<AEHH@FCGBA<CDGBFFGBFHF-=F@F;@E@EDHGEHC7=;@BDEC9AACCCBBB8?BCCCCB?CB4>:@C@<?B
@3TH
TCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATG
+
@@@BDDBDFBDCDEFF?BEHEE::AHD9AEFHFFEGFI4BBFF<FGCFEFIABFF=@88@C3@C==@CE@AECFE?<;?56>BBAAD>@BBBABB@;:@A:
@3TI
CCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCAT
+
BCCFFFFFFFHHHJHHJIJJJJJJJJJJJEGHIIJJJJJJJJJJIJJGIIJJJJJJJJJHIJJJJJJJJJJIJJHHHHHFFFFFFDEDDABDDDDDDCDEE
@3TJ
CACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTT
+
CC@FFDBDHHHDHCAGGFGEACDGG?CFBABBHGIGEGIIIIGIECHFBHIIIIHEHEHFFBCEDECACECAC>@CDDCC?C?CDDCC<8ACCC>CCCC:A
@3TK
ATCTTGTCCTTGGTCGGGCTGAGGTTGTAGCACTCGGCCAGGAAGACCTTTCCAAAGGCTCCCTCACCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTT
+
CCCFFFEFFHGHHJGIGHJIJIIFGHHIHGHIJJJIGIIIJJJIJJJJJJIIIJJJHHHHFFFEECDEDDDDDDEDDDDDDDDDCD>BD?BCDDCDDDDCD
@3TL
GGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGG
+
@@@DDFFFHHHHHJIJJJFHIIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHEHHFFFFFFEEEDDDDDDDDDDDDDDDDDDDBABDDDDDDDDDDD
@3TM
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@CFDFFEHGFHDIJFEGIGJJHJEHHIIIHJJIIJJJJEHIIGIGDHFGGHGIGGIIEGHCHHIHFHHDDFFEEDB@CCCCDCD;AD<B:>AC>CCACC
@3TN
CACAAATGGAGGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTCGAATTGAGGGCAGTCTGAGTAAGGATAAAGTTCTGAGTTTGAGAGG
+
CCCFFFFFHHHHFHIJJIJJJJJIJJIIFIJIJJGIJIJJJGGGGIJIIJHHFDFDCDEDDDDDDDDDDDDDCD@CDDDDDDDDDCCCCDDCCDDDDDDDD
@3TO
ATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGGGTTGTCTT
+
@@??BB??<CDFDI:<CCFFH93C<3<C,,++2<C9+9CFBA99CFFIIIC>FFFFC<B9?3@?@B=;FF4CAFE4=7)@D:;=73)7;7?)661=BBB@
@3TP
GTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAAT
+
@??DDDFFHFFBDAEEHEHGGBICHGCA<<?E@F<C9CDGIGIIEH@F@BBGC?:DGB>FHG=ACFGA.=C@DA>BE<B9=@C>;.>A>;;@ACC;@D>>@
@3TQ
GTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAA
+
CC@DFDDDFBDHFIII?CEBDGIGCEHIIIHCHHGIGGIIDEGGCGIIIIIIIIGDHIIIIHIIIIIGIIIIIIIIIII@GGHIHHHHHEFFFFFFFEEE
@3TR
CTACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGG
+
CCCFFFFFHGGHHJJJJJJJJJJJJJJJJBFIJJHIJIHIEHIJIJIIJJJJHHIJJJJJIJIIIGGIIHHHHFFFFFEEEDEDDEDDCCDDDDDDDBDDD
@3TS
GGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGCTTCTG
+
BCCFDFFFHHHHHJJHIIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIIJJJJIJJJEHCEHHFDDDBBDDDDD@@BDDDDEEEDDDDDDDDDDDDDDD
@3TT
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGC
+
CCCFFFFFHHHHHJJJJJJJJGHIJJJJJJJJJJJJJJJJJJJJJIJHIJJJJJJJJJJJJJIJJJHHHFFFFFFFEEEEEDDDBDDDDDDDDDDDDCDDD
@3TU
CTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
CCCFFFFFHHHHHIJJJHIJJJJJIJJJJJJJIJJJJJIJJIBFHIJJIJJJJJJJJJJJJHHHHHHHFFFFEEEEAEDDDDDDDDDCCDDDDCDDDACC
@3TV
CAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJIJJJIJIIIJJGIJGGHIIJJIJJHFHHHFFAADEEEDDDDDDDDDDDDDDDDDDDDDDBDDD
@3TW
CCAGGCAGTTCCTGGTGGCCAGGTCTCGGTGCACAAAGTGCTGGGAGGCCAGGTACACCATACCCGAGGCGATCTGACTGGCAATGTGGAGCATTTGGG
+
CC@FFFFFFHGHHJEHIIIJGEFGIJJJJIGIJJJJJJHIIJJJJIGFGIGIIFHHGIIIJJHHHHFFDDBBDBDDDDDDBBDCCDCDDCDDDDDDDDD
@3TX
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIIJJJHHHFHHHFFFFFFFEEEEEEEDDDDBDDDDDEDD
@3TY
CCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTC
+
@C@FFFFFHHHGHJJJJJIIGIIFJJJJJJIJIJJJJIIJJIIJIJIFHEHGGHFFFFEEEEDCCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD5>BBD
@3TZ
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJEFHGHJJJJJJJJJJJJJJJJJIJJJJJJJHHHFFFFFFEEEEEEDDDDDDDEEFECDDDDDDDDDDDDDDDBDDD
@3U0
CTTGACCACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTT
+
@C@DBFFFDHHGHIBEG<ACEGEEEGFHGEGHGDGDGGIIIIIIEFHGIIGHDHIGEGGIGG>BEEEDFFDCE@CC@CCCCCCCCCC:ACCCCCC@>A:@C
@3U1
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCA
+
@CCFFFFFHGHCFHIIIJJJJJGHJJJJJIJJJJJJJJJJJJJJJIJJJJJJJHHHHHFFFFFFEEEEEEDDDDDEDDDDDDDDDDDDDDDDD
@3U2
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGT
+
B@+ADFFFHHHHHJGIJJJJIJIJIHGEHGIJJJJJJIHIJIJJJJJJIJIGIIJ?DHFHGIEHIIJJGIJHHHHHADFDFCDDDDDDBBDDEDDDDDDD
@3U3
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCG
+
@@@ADDDD??:+<EBCC?3CE@G@1:?C?C:FBC:::::?DDB*0099?099B.=F8=FGI>.8)5@.6A457?7B6(=8;98;8(8?BB<(++>:4((+
@3U4
GCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGG
+
CBCFFDFFHHHHHAFHIHIIJIJJ?FGIJHIJJJJJJJJJJJJJJJFHIJJJJJJJJEGHHHHHFFFDEEEEDDEDEDEDDDDDDDDDEDDDEEDDDDDDD
@3U5
GGTCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCC
+
?::4AD:=CF?<FFEDG@EGCF@HAEH@B?*1CFDHBHBG;FFHGIIBF?FE@FHBC;F@@GADGIIEB599>C;6@@CCCC>5;CBB<<:(>2?@?::AB
@3U6
GGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCC
+
CCCFFFFFHHHHHJJJJJJJFHBEHHHGFFFFEEEEECCDCDDDEDEDEDDDDDDCDDDDDDDDDDDDDDBBDCDDDDDDDDDDCCDDDDDDDDDDDEDCD
@3U7
TAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCC
+
BC@FFFFFHHHHHJJJJJJIJJJIJGHFHIGHIIIJJJIIJJIGHIIIJJFHHIIJGIIIIJIJJGJJDIIEHHFFDBDDBDDDDDDDDDDDDDDDDBACD
@3U8
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHFFFFFFEEEEEEEDDDD8?DDBDDDEDDDDD
@3U9
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
?@=BDD2ACFCFFIIIFDGEFIF3?EDFBHFCFDF<CDFGIFGIIIDGFFEDEFFIIFIIIIIIII7@B:CFE=EDDBDB?BD;@AB.;?B@BBB@?@B5<
@3UA
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACT
+
@@8BDADDBHHFDAG@E@EEEEHGDGIII@HD;BGFC<FGG=<:4@AA@D>GEE===@BDCDDDDDCCDDDDCDDCC@CCCB?:?CDCC>?@BB9<CCD@>
@3UB
AGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGGGGTCTCTCATCTCTTTTCTTT
+
?@@ADD8DAHBFBGHHIBGICEEFHIIIHG@3CDHGCE@BFDBAEHIEA>CDEEBBB3@B=?8;6=:AC@@@>B9?A33(00&)3>AA>4@:34+:@:>C@
@3UC
GGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGGGCAGTGACTGGCTGCATGG
+
@@@ADBADFAD?<EDFG::CDHEH9:C4AFCHAFEFEC?B@::DEBF9?FFFIFFCFI@GDEFE;D.=BF(7?;3@CC;>='8;';94@>(:@?@B??ABB
@3UD
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
CCCFFFEEHFHHHJGIJJIJJJJGHIJGHIJ:DGIHIIIGIJBFGCHFGGHGIJJJJJJIJHHH?DDFEEEDEEDCCDDDDDDDDDDDDDDDEDEEEDDDD
@3UE
CCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGAC
+
?@1=A:2==C?F@)22@8:)8:*9DGBFG900990*?FF67-@FF<E;8C=7=BDD;;(;;(.5';?BB@@BB=<((++9(:-+2((:A>@<8((+2(+8
@3UF
CATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCG
+
@@@FFFEFHHHGHGGIJJIBGGIIJGGIJJIIIIJIIEGFGHIIFIHIJIGGIIGGEAEFEFFDDDBDDDDC@@DDDDCCDDDABDDDEEEDDCDCDDAC>
@3UG
AGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGT
+
@CCDFFFBFHHHHJJJJJGIJJJHIJJJJJJJJJJJJJJJGGIJJJJJJJJGHJJJJJJHHFFFFFFEFEEEEEEDDDDDDDEDDDEEDDDDDDDDDDDDC
@3UH
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGT
+
@@@DBADA<DFHFHG@CHIGHGI>DGCGHEDDBAHEGCGG9B?FGH)8BFHIIGGCAEHGIIAEEEFEBDCDDC@@CB=?;?CCCCCCCA@>CCC3::@C@
@3UI
TTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAA
+
@C@FFFFFHHHHHJJJJJJJJJJJIIIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJGHHHHHFFFFFFEEEEE
@3UJ
TTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTG
+
@=<DD;DABF=??BAEGB?FFHHEEFEEA?BFHGEDG@?*93?C?<G<DE?FFFCFF72=F3B@;FF;=FE4=C;))=EEAB;;;?.66.>@A>AB;@3
@3UK
CAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCT
+
CC@FFFFFHHHHHJIJJJJJJJJJJJJJJJJJIJJJJGIJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJHHHHHHHFFFFFEDEECDDDFEEFDD
@3UL
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
CCCFFFFFDHHGHGIJGFHIJJJJJGIGHHHBGHGIJIIJIBGGIGJIFGHIGHIIIJIGIJIIIIIDFHDEDFFDEEEEDCDDDDD?CCBCDDD29?B@C
@3UM
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACAT
+
@@@DBDEDA>FDFFAFGD:FGH?CCBHGGHEHCD?FEF?DBBFDGGHGBG>FDF:@GGEEEEE;@;?B66>;3>5;;@CCCCC@CCA@??@ADAC>CCC:C
@3UN
CACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
@?@DDDB@<AD<FEG?E?FHIIEG3)8E??:DG@F??F8/8(7C;7CFE@D;77AF9<B:AC>6;@B;AB=;828344>4+33@3<ABB4:@??@?AA>B
@3UO
GCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTG
+
CC@FFFFFDFHHHIIJJJJIIJJJJJIFGIIJIJJIGIIIIJJHHIEHJBCGEGIJJJIJIIIHFFEHCDFFFDCDCDBBDACCDCDCDC>CDDDDDCDDD
@3UP
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
=:;D?;:2=C?:A<EE2C?F9A<FA81?EE<DB?CDFB900:?D99??9BD<<6A:;A78)7-7A</???;..;(;A3;@=A3>;555>A>5>;>;555>A
@3UQ
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
CCCFFFFFHHHHHJJJJJJJJJIJJIIIIJHJJJJJJJJIJHIJJJJJGJIIIGIJIJJJJIIGHHGHHHEFCFFEEEEEDDDDDDD<CDDDDDD?CDDDD
@3UR
CCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGG
+
CCCFF?DFFDDFHIJIIJJIJJJJIJGHGDHIJIIJGJIHHICFGGIGGHGIGHIGHGIJHGIIJIEHCEFDDBBCAAC@CCCCD5@CB@CDD8?BDDDDD
@3US
GACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGC
+
CCCFFFFFHHHHHIJJJJJJJIJJJJJJJJIJJJJJJJIJJJFHIJJJJHHHHHHFFFFDDDDDDDDDBDDDDDDDDDDEDDDDEDDDDDDDDDDDDDD
@3UT
TGTAGTCGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGG
+
???DA,AD:CD::E9BEB3AEE:E81*?AAA6;<B2=CCEDCD>AD9).7ACA16(7?AAAA>A@A:5>>(>>;>=(9=<:>39>A>>A49>AA>4;9;>?
@3UU
TGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTC
+
CCCFFFFFGDAFCFGEHB@:AFDGEE?CFHBF?DHGGEGAFHIIIIIIIIIFIC@HA=FHIGG7CHFHHHFEFDFECC??BBBBCCCCCCEACCCECECEC
@3UV
CATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGG
+
?@1ADEFFHGHHHJJJIIJGIGIJJIGGGEGFGHFEDD<FGFFGGGGIJJIEGEHGHGIIJGIIIEIIEGEEHHEHFFFFDFED?B@BDDDDCACDCDDDC
@3UW
GGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
1;14ABDDFBDAFDEAEI@;FEHIII9?CHGCGIIG@F@FCFHII>@;FCBCCCCDDHD=@GCEHHEHEHHEDEEDDC>ABCBBBCBBB?@><@CCC>BCC
@3UX
AGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGCGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGC
+
==+BDDDDD?C?BGIE@?B;BFFFB:?CFCF8?:::B;BBBG(7-<;/6CE;=5?4B<;@;;A?;A=>:<>9A>?BBBA>4@4::+:(228?<<28(44+(
@3UY
GTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGG
+
CCCFFFFFFHHHHJJJJIJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJHHHFFFFFFEEEEEEDCBDDDDDDDDEDEDDDDD
@3UZ
TGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGG
+
C@CFFFFFHHFHFHIJIIIIGGGGIIHHFHHGHIJEDHHEHIJJJJGHGGJJJIJJIJEHHHHFFFDDD?BBC@?BDC@CDDDDDDDDDDDD<BD2?CCBB
@3V0
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGG
+
@@;DDDEFHADFHHIIIBAHEGEHIFHIGGGGIIBHC@GDGGBFG@FD?CCD=FE;7@@GFH@EEEHFHDFDCFFDCECCA@BB@BBCCC@AC>@CCA:>C
@3V1
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
CCCFFDDFFHHACGIJIIGHGHDHIGDHGBEHIFGF@BFGHBBFHDIGIGIIJCGGIJGIHGGGGJEHHIJ@BE=BCD@>@CDEEEDEDDCCDDDDDDDDD
@3V2
CTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTG
+
@C@FFFFFHHHHHJIJJHIJIJJJJJJCHHIJGIIJJJJCFHIJJJJJBGHIJEGHGIIGHIJJJJJIHHHFFFEEEDCEEDDEDDCCCDDDDDDDCEDDE
@3V3
CCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTC
+
@?@A=@DD?;FF?;AEG<BBD<B@EAHDEG8DAFBFHHGGFG;DBG0AGGBHHEE?AC@BBBC?B<<ACCCBBB05?>8??<>@D4<>CC>:<@BB?@B@C
@3V4
ATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGC
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJHGHFFFFF@CEEEEDDDDDDDDDEDDED
@3V5
GCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
@<?D<D:D>?DFDDBGBEDHIAFFHHCGDFIE@FCF8?DFD?0:BBF9??FDFFIFFB@>C==7C7;2;=535=?=;:A995,:A(,>AAAA:498:@:>:
@3V6
CCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGGAGTAGCTGAAGGTGT
+
CCCFFFFFHHHHHJJJJJHHHIJJJHIJJIJFHIHIIJGIIIIBFGIIIHIJJJJJJJJJJHGHHFHHFFFDECEEEACDDDDDDDDD<?ACDDDDDD9AC
@3V7
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
@?@DDDFFHHGFFIHIGIAHHGIHIIIGCHHGIIGGGIGGEHIGBGHIII?ABEGGBDDBCCD=ABDDDBDDDCBBBDDBDEDDDCDACAACCC>CA3@
@3V8
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
@@CFFFDDDDHFDGHIIJHJJEIIIGICGHGCGIJJFIJGJJJIIFHIGIJJIIIJHIIGIJIGGHFFDFAA>CECDCDDDDDDBBBCDDDCD:AC>CDD
@3V9
CTTCCTGATACTCAGTTACACACTTCTCAACTTGGAAGCTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCAC
+
CCCFFFFFHGGHHIJJJJJJJJJIJJJJJIIIIIJIJIJJJIIJJIIJIIJJJIIIIIJJJGHIIIJJIGIIJIJJEHFGDFFEFCEEEDECDCDD
@3VA
CTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTC
+
@<;BDDD?BBADDHID@FHICEEHHBHHGIHIIIIBBC@FB@?DE?F@DHHIEHDGHHBB@;0529<C?<9<CCCCC3(4>9<@C:@DDD:39A<A(:>AC
@3VB
GACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTT
+
@@@DF>DFDHGHFFAGIIGCHFHIGGIGCH@F@HIGGGFHGI@FGIIGHHFEHGHFCEBCBB@ABBDD<?<@CCDACCCBCBACEDDBDDD<B>BBBDBDC
@3VC
GGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTC
+
@<?DDDDDH>D?2AGFB>FHD>CBE:CCHC@3<CCCGHCBCF@@*::??9FDDEF@FH<5=ECB7@D>;>6=<B??BBB9>@>AC?9<>CC(+<@<??39A
@3VD
CACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCG
+
@@@DDAB8@8:8?):?CEEF<FAGDFBFBEB?DD@AB9>>;;>>@;?BBBBA>>3<'&07;AB>BBABBBB:A93++(++9<BB>@@:4:>:@>>>4@BAB
@3VE
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
@C@DDFDDHGHHGGIGEGGIIJIJJJJGGIJIJGIJGAGHHGIEGIIGGGEHGGGH>BFGIBGIEDGFCEEEFDDFFEDCD@3;?B;A>>CCD:ABBDBDD
@3VF
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
@CCFFFDDFHHFHIGJIIJJJIJJJIGIJIIGIIIJIGIFGEHJIJIIEHJIJIGJEEGIECEEFDCEFDECCEEEEECDAACCAADDDCDBBDC<8@9<5
@3VG
GTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGT
+
@CCFFFFFHHHHHJJIJJJJIJJJJIJJJIJJJIIIJIIJJIJ?FHIIJJIIIIIHIJJJIIJJJJHGGHDFFFFEDDD;>BBDD=BCDDDDEDDDD@CD4
@3VH
GGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCA
+
C@CFFFFFHFHGHJJIIIJJJJJFJJJJIIFHIIJJJJJJJJJJJGIJJJJJJJJGIIGIJJJJIHHHEEEFFFFFEEEEDEDCCDDDDDDDDDBDDDDD
@3VI
TCTTCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAGTCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTG
+
B@1DDDFFDHGHHGIGIFJIJJIIGHGHHGIGIGIIGGHIIHGGHGHIIJFIIGHIGICGGJGHGEGGHIGJHHHCDFFEFCDEEEEEEDC;ADCCCDCCC
@3VJ
GCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTC
+
@C1DDFFFHHHHHJJIJIJJJJJJJJJJIJJJJJIIJJJJIJJJJJJJJJJJJIJJJJJIJHHHFDDDDDDACCCDDEEDCDDDDDDDDDDDDDDDDDDDD
@3VK
TCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGA
+
@@@DADADDDADBFGGGIFBFCEGGIEEHGAAGGIGGEGFGGGAGFGIDHHCHEGEGEEHDAEGEGGGCEGCEHE:C>?D=@CCC@A?>@>>>CCCA>C@
@3VL
CAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTT
+
@<;DDAABDHHBB;CEB<?FCHEHIAAFEHFGGAGG<DDG?CH<GDH?GG<?BBDF;FGBF>FG==@@HIHHCGCC;=AE;.7;@@BCCCCCACCCB@@C
@3VM
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCA
+
@@?DBDDB>CFFFHAHFHIIIIGIIIGGECHEIEIIFEFGAHHIFG?DHICHBHGHIG@EHDDGEFCCHFHEFFFDFED=BEDDDDDDDDC;>;:>ACB?
@3VN
CTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGT
+
CCCFFFFFHHHHHJJJJJJJHIJJIIIJHIJJJJJJJJJIJJJJJJJJJJJJJIJJJJJJHGHHFFFFDCEDDDDDDDCDDEEEEDDDDDDFEFEDDDDD<
@3VO
GTAATAGCGGAGAGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTA
+
???DDDBB?<D8)<EE9EEEA7DD900BDDDED9DD??DE<DA8=BBBACCEDI>C;AE7)=AA>DD@@;>6;6;2<<+<<AAAD>:<>8:>AA>A(:::
@3VP
CTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCA
+
CCCFFFFFHHHHHIJJJJJJJJJJJJIJHIIJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJIIIIIJIJJJJIJJJJHHHHHHFFFFFFFEEEEEEED
@3VQ
AGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTG
+
;?;ADB:22C<BAA:<<?CE9FE?33+<BF@+23:E;DDAD)?<*B??D<<??9?BDA''-55?)7?;3.;;==;';;9=(559<A:>((++(4444491
@3VR
CTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGT
+
CCCFFDEFHHHHHJJGHIJJJIIJJJJJJJIIJJIGII??C?DGIJIJJJIGIIIIJJJHGGHFFFFDFDEEEDEDDEDEEDDEEDDEEDDDDDDDDDDDC
@3VS
CCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATC
+
???D?::AD:D<:<EA9AFD:ABD@@ACEFAE<*??EEFIEF@DB?9993?DEIIIDDE<D?8B@C=DE7A7C78AC=@CA7)?C>?A@;AA@@A>A55>
@3VT
TGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTC
+
@@@DFFFFAFHHFGIEHGGHFHADF<CHGGIIGEHIID?DHIIGEGGIHIIIICGIEHIIIIAHGE@FHIIBGGCEEDEHHHFDDDECCAEC?CCCCCCCC
@3VU
CCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCAT
+
=8+BB=2B)<C@AFF>CFIFFFDFB@;?9?GED7D:F<6BBF<=(;@;5@C>7AC>7;=B=??;A;;;>>>@BA=@>BBB3:>4@39:48>>@B@BBB:A
@3VV
TGAGAACACAGCTCATTGATGTAGCTCAGGAGACCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJHJJIIIGHJIJ909?BFHIJJJJJJGJJJIJJGHIGHHHHHFFFFFFEEEEEEDDDDEEDDCDDDD
@3VW
GTTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATG
+
CCCFFFFFHHHHHJJJIIHIJJJJJIJJJJJJJFHIJJJJJGHIHIJIJJJJJJIJIHHFFDBDDDDDDDDEEDEDDDDDDDDBDDDDDDDDDDDDDDDED
@3VX
GCGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCAT
+
CCCFFFFFGHHHHHJJIIJJJJJJJJJJJJIJJJJIJJJJJJJJJIHHIHIJHHHHFFDCECEEDDDEDDDDCBCDDDDDDDEDEDCCDDDCDDDDDDDEE
@3VY
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
?<@:BDDDFFFFHE@??CGGGGHFC?GFFFHDF6@D@DFHEGIIGHGGGG?C=;AGGIGA@ACC=737;;BB);=6>A:;@A?CC;AC@?==)5955>>:A
@3VZ
GTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGC
+
@=?DDDD?FDBA?GFF<CECFEHEHCGGHEHID>GEHII;DCD;B79BDDGIFHE@=@@GE@==)(.@=E6=ACDE;;7;BDC>@;;?CBC=8@@C:9?B5
@3W0
GTAGCTCAGGAGACCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCC
+
???;4B?+=;DD>E=EE;D9BEE<9E9+4CCECEEDEI>DDDEC?DDDEADA?@BC>C@AA;@8ACCDD=7?>A.=)=?ADAD@A?AAA??>59((5:>>>
@3W1
GTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTT
+
@@<DDDADFHDA<<CBGGEHGGEHIHGEGGCGGGGIIIGG@FHIG??FGBHBHEGGIIG@BEHHF9CBEAA=AB?@BDDD@<@><BBBDDB@CEDDCCABC
@3W2
CAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTC
+
@@@FFBEFHHGFHIJJIIJJIJHGGGGHIIHIIJIIIEFHIJGCFHEGIIJIIIIJJHHFHGHCDFFFCEDDEDEDDDDDDDDCDCCACDDBDDDDCDC
@3W3
GCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTC
+
@@@D?DDFHHGDFFHHBBEHGHGGEGGIIDEEFBFDEBGEII<DB?DGBECFHID;CHIGHIBCCEHHFFBA6>AACACCCBDD<5:@559A5?<BBB@C
@3W4
CGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCT
+
C@CFFFDFHHHHHGGGEGDHGIJGGHIJIIGGHIIJIGIJGIGEIJIGIJEHJCCHIGII:?ADDDB;BBDDCDDBBDBBBADD99BBBDDDDDBABD>CC
@3W5
TTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCAT
+
BC@DFFFFHHHHHJJJJJJJIJJIGIIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJIJJJIIJJJJJHHHHFFFFFFFEEEEEE
@3W6
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCAC
+
CCCFFFFFHHHHHEGIJJJJIJJJJIJJJJJJJJJGIFGIIJJJJJFGIJJJJIIJJJJJJIHIFHGIGCEHFFCDDDDCDCDDDDDDDDEDDDDDDDDDD
@3W7
TTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGG
+
@@@DDD3=BAFFDA@EEF<443)?)1?BBF<FGHIIH>?'6CF>;@GDH.=AA>==B>@.66>5;(5(;:@:(5<?@C?A@:>?B5833(((+4(:89)0&
@3W8
GACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGG
+
@@@DDDDD8?DFDHBGBBFGHBGG>EEE>>:;FFH98BB?C78@@DGGBCEH>AHBFE@@@A/?B@CCAC?3(98;<>@??<@B@C<>ACCCCCCCCCC@B
@3W9
ATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGG
+
@@@FFFFFHGFH@FHIIJFIHGHHIIJIJJJIIJGIIJIJJIEHHGHJJJJJJJHHHFEFFFFFFFDEECEEEDDDDDDDBCD@?@CDCCDDCCDCDCDDD
@3WA
GGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTT
+
CCCFFFADHHHHHJJJJGHIJJIJJJJJJJJJJJJJJJJGHHJJJJJJJJHHJJJJJJHHHHFFFFFFFEEEEEEEDDDDDDDDDEEDDDDDDDDDDDDCD
@3WB
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCT
+
@@@FFFFFHHHHHGGIIIIJJJJIJJJIGGIIDHDHGGHDHJJIHGGBGHJJJIGCEEHIJJJJJEHGHGHFFHGHHFCFBB;?@C>CC>?;?BCCCC@@C
@3WC
CTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCAT
+
?@7DDAB;2A?FBGGGD?AA@H?FGBEFHE<C=;CF<C9DGBD;0B<??B?BFFFFH@FH=G)7@GIGIGHI@)@A>=ACC?;7;>7;;66@6;B>ACC@
@3WD
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
CCCFFFDFHHHHHJJHIJJJIJJJJJJJJJJJIJIIIJJJJJJJJJJJJIIJIJJJJJIGHGHFHFFFFFFFEDEEEDDDDDDDDDDDDDDDDBDDDD<@D
@3WE
CTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCGGGGTCTCAAAGCCGATTGCAATCTCGTCGGGGTTGGAATT
+
@@@?DADDDBHFDEH>A?93C@:E4ED?CGG@6))6DF99*/?CF0;;>.7(=3=<B<<A'3;=,395(:(+(+0&58(:(4>A4:8++0-&))&004@>:
@3WF
GTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
@@@DDDEDHFBAHIGGIGIHGAHGIGIIIIJIJIGGFIIIHIJJGIIGGIJJDHHCFIHIEEDCFGHIIDHHGHFF;@DCEECAEDDDDDDDDDDCCDDDC
@3WG
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
@@?DDDDDAFHFFIIGIIIA<F>F9;FGC?;C?B@FGCHHIEBBFEGFGCHGEIIIEE@CFC>DD;==A=6@@D@;CCCCCCDC;@B389><@C>A:>A>?
@3WH
GGCTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGATCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCAACATGT
+
::+=+B:ACAFA<CA<A?F@@E<F>E@EH4AA2<<AA9:91:4*1?F??**00B?*0??**0?839D888=FGC)@F==FC7=DD7.7?3=CEDD)..7..
@3WI
GGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGC
+
@@@FFBDDDDFHDGGFHGIIIH@EFG@FEAGGICGGGGEFHFGHGHJEHIGIIHHHGHFFFFFEEEEEEDCDDEDDDDCCDDDDDDFDDDDDDDDDDDDDD
@3WJ
CGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCG
+
?=;?DABA>>BF?:A?@ADHAFFHF<AAF8<E<E?EBA>9CBFAGF:68DFDC<<8=BCEFFFCD=;7@5=AAB29?;=35:@BB?B?@@B>AA<@BBBBB
@3WK
CGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTT
+
@@<DDBDBC?<AC<C<<GBA?FGBFGFH<HEEH@GFHIGGBDHHIEGC:BB<?GHIGB?DG=BCEHEHIA@GCFHE@C>CD7?>==ADE>;B@;;;AAC;;
@3WL
TGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAAT
+
CCCFFFFFGHHGHJJJJJJJGEGIGIIJIJJJJJIIJIIIIIIIHGIGIJIHGFIJJIIIGHJIJJGGHJJJJJFIIICHHEHHFFFFEDCEEEEDDDDDD
@3WM
GAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGCCCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTT
+
=;1B=BB?DBD8D?@GHBFHGHH><CHGIHGIG@EB@9?D@DG>?<?3*0?>D;FHGHEIICBEECB===FDFGHII@;;97AECDB;7@BB;@ACCCAA
@3WN
GTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCT
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJI;FHHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@3WO
CCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACG
+
CCCFFFFFHHGHHJJJJJJJJJJGHIJJJJJJJJJJIJIJIJJJJJJJJJJJIJIJJJJJJJJHHHHFFFFFFDDDEDEEDEDEDDDDDDEDDDDCDDDDD
@3WP
GCGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGG
+
@@@DBFABDHF>CFGBBGDHFHIIIIEHGEHCH<@?BCDHIIGIEGGAFGIIIHIIGIEGGIGACHGCECHH;@D@AD;;@CBBCCC@BCCB;8@:9BBBB
@3WQ
GGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTC
+
CCCFFFFFHHHHHJGIJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHHHFFFFFFFEEEDEDEEEDDDDDDDEEEEDDDDDA
@3WR
CATCCAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGC
+
1=?B1?BB@<:@?B9B:CADD@BE91::BEDDD@DBDA?DE<BD@=BAEA5;;@A==)=A?;ADAAA;@>A;@A3;;:=8AA>?><<AAA>>>A>>?
@3WS
GTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCT
+
CCCFFFFFHGHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIHHHHHHFFF=@BBDDDDDDDDBDDDDDDDDDDDDDDDDDDDDDD
@3WT
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCT
+
CC@FFFFFHHHHGJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJI@EFDEEEEEDDDDDDDDDDDDDCDDDDDDDBDDDDDDDDDDDD
@3WU
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
???DDADDCBB2A:<:E?FE@@0:?DD9D0?B8?1?1(8;8===CA=7A@=@@?=?CD>D@;7A>AA>;A>>>;;5;>AA>A5>AABAAA>80+9.2:>>>
@3WV
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
B@@DDFFFHHHHHJJJJJJJJJJJJJJJJJJJHJJJJIJJJGIIJJIJJJJIJJJJJJJJJIHHHHFFFFFFEDECEDDDDDDDDDDDDDDDDDDDED
@3WW
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
@=@DFDBDBF?FFGIGGGGIIIEGIIICHHIJGGEHBGIGIDD>HIGJJIJJIIGIG7@FHIII@GIHFHHDDEFFFC>CCCCC>?@BDC<ABCBB<8?9B
@3WX
CGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
:?+4ADDFFDFHHGEGGCGFEFHGIGIGGGEHIIIGIIHIIIIIIGIIIIGHGIIIIIEGIHIEHDHHFGFDCBB5<A>CC>?:ACCEDDDDDD<:>CB
@3WY
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJHJJJJJJJJJJJFHIIJJHHIHIIJJJJJIIJJDHHHHHHHFFFFFFECEEDDDDDDDDEDDDDDDDEFDDDDDDDD
@3WZ
TGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGC
+
CCCFFFFFHHHHHIJJJJJJJJJJIJJJIJCFHIFFHIJIIFHIJIJJIJJJGGHHHFFFFFDEDEEEDDDDDDDDDDDDDEDDDDDDDDDDDDEDDDDDD
@3X0
TGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
@@@FFDFFHGHHHGHHIIEGHGGIJEHGCEHHHJGIIDBGGGGIHDFGC@FHFFHEEHIHGEHHDGAHEFFFEF>C?CA@?BB=?D8??<?@CDCC@AC
@3X1
AGAATAACCAGGGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGGATAGCTGACATCAGTGGGCTGTC
+
:1+4A=B:2:A+<EDE:E=B3?@AA?0:B?49B9BDDD@D38@8':=@;AD;>AAA>>>9-5>>3:>>?5:::A=?>&()99>>:><A4>>:(+(8(3;((
@3X2
CTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGC
+
<@<DDDDFH:;BDGGCAGFEGGECGGGGG:@DFGGGGGIFGGHIAGGGEGBHHFEHCHCCDFDEEEEEECCCA>CCCCBABB@CCCCCECCCBB?C@>AAC
@3X3
TATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCC
+
@@CFDDEDHHFBFEHGGGIIIFBHHIIII>FFFHHHEH@DGE@=CGGGHIGCGEHFHBEFEEEEACCECACCCCCCCCC@CCCCC@>ACDCCCCCCCCCCC
@3X4
CTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACAAATCACATCGCCATCTTCACCTTCAAAGCTTTCATTTATGACTCCACTGTTGT
+
CCCFFEFFHHHHHJJJJIJJJJIJJJJJIJIIIJJJIJJJJJJJJJIHD??BFIIHIIJJJJJJJJJJJJJJJJHHHHHHFFFFFFFEEEEEEDDDDDDDC
@3X5
TGGTGGCTCCAGTCTCCCTCCTGTTTGCACATAGTTTAACACATCAAGGTTGGAATGAGCTGGATAAGGCTGATGACCAAGAGTTAAA
+
B@@DDFFFHHHHHGIJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJFHIGHIIJJJJJJJIIIJJIIIGHHHHHFFFFEEEEEEE
@3X6
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
C@@DFFFFHGHHDEIGIJFIGJIJGJIJJJJIGIGIIJIIJIJIJJJJJIJJIJIGGGIHFHEHFFFECEECEDDDD=BB9CCCAACDDDDBDCDCDDDD>
@3X7
GGGGCACTCTGGGGCACTGCACCCCCAGCCAACCTCACATCAATGAATGGGTAATTGACCAGCACCAGTTTGTTGAAATTGAACTTGTAGGTGAACCGTTT
+
@@CFFFBEH?CBA@@AFHGCGEHIIIIEGHGGGDGGIIGGIEGGIBF=FHI8@@HAEGGECCEEFBFDCC@C;@A@CC@CCCCCCCCCC>@5:>>CBB@BA
@3X8
CTCTGGGCTTTACGCTGACGCCGGCGGGGGGCCCGTGTCTTGGGGGCTGCCTTTTTCGGAATGTAAACTGGCTGCTGGCAAACCTCAGAGGCCCGGGGCCC
+
@=?;D<:?ADA?D;1+@@?C6@?@<FAD@-&500&)&((+3>8()0)&&2<3>(+:35588<@>3(+:::323+(:>4(9@B@7(9>9@:0<<(&09>&&)
@3X9
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
@@@FFFFFHFGGHJJJJJJIJJJJJIJJJGHHIIFIIEHGHGGDGHIIJJIJJJIJJIIIJHHGHHFFFFDEEEDDDDDDDDDDD:@CDCDDDEDDDDDDD
@3XA
CTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGG
+
BCCDFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJIIJJJJJJJJJJJJJJJJCHHHHHHFFFFFDEDDDDDDEFDDDDDDDDDDEDDDD
@3XB
TAAAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
:?1=BDDFHHDFHIGGIJEHIIIGIIIJIJCHGIJJGHEIIIAFBHIIIEIJJFEHHHECCFF@DEDCECEDDDD;@>CCDDDDDDDDCCECCDDDDDDD
@3XC
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
@C@FFFFFHHHHHJJJJJJJJJJJJJJJJIIJJIJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFEEEEEEDDDDD8?B<CDDDDDDDDDDDD(>CDDD
@3XD
CCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGC
+
BB?DDEFFHHGFHGIJIGIIJIIJIJJIJJGIJIJIIIJJJIJJJIIJJGIIJJJIIIHIIJJJIIIBGIIJJIJJJIGIJHHHHHHBDDFFFDDDCDDD
@3XE
GGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAG
+
CC@FFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJIJJJJIJJIJGGHHIDHHHIIGGIIJHHEHFFFFFBCCEEDCDDCDC@CDCDD
@3XF
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
<@@FBDBDFHDDDIGIIIFGGIGIHIIIIDB?DGGIIIIGEGHIGH@GHGHIIIIGGIIIIIIIIIDH>DEDA>C@>;ACACCCB?BBCDDDDBBACDBB
@3XG
CTGGCGGGGCACTCTGGGGCACTGCACCCCCAGCCAACCCCACATCAATGAATGGGTAATTGACCAGCACCAGTTTGTTGAAATTGAACTTGTAGGTGAAC
+
?@+=DD??DHHHGGEGIIAEHIHHGEHFFFCCBBCCC@?BBBBBC8AA@@99ACCB3>ADCCCCCCBBCBB?AA@DCBCB@CCCCCCCCCAC4::ACCAA:
@3XH
TTTCAATCTCTTCATTTAGCTGAATACATTGGTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGGATGTG
+
1==4+,=D<C8:<24<<AF>AFIF4F9:AHH3AEGG91:C3CAGA<40BBF4*0908DF*****8B8888=@@;CF@@)7C@251ABB@..)(.6>A;(;5
@3XI
GTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTG
+
@@@FFDDFGHHGDBBHGGCHHIGHGHIIJJJJGICGEHIIEGIGGGHIGDGHGIJFIIGIIGIIIIJGGIJIEHHB>=;BEFFFECCECECDDBDBB@DD?
@3XJ
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGATATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
??;;DDDBADDDB>BC)1C99ACFA?C):3::)).79B==92B1;5A7A@AED>?4'59>;@>A(-(555:8;2;99:4:A>99>A?AAA<((<8>A>A:A
@3XK
GTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTG
+
CCCFFFFFHGHHHHIJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJIIIJJJJIJJJHEHHHFFDFFDEEEEDDDDDDDACDEEDDDDDDDDDDEDDDDDD
@3XL
TCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTT
+
81:BBDBB2=2CD9E?<EAEBAFCCE3AEFB4A9EBBEECDEB?D@BDE>DDDB?D4899=;;@CDA75.-.=?CDDD7;.;;;6>6;>@3;>;;5>5,5:
@3XM
GGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAA
+
CCCFFFFFHHHHHJJJJGJJJJJJJJJJJJJJJJJJJJJJJHIIJGIJJJJJJJJJJJJJJJIIJJJJJJJJJJJJIJJJJJJJHHHHHFFFFFFFEEEE
@3XN
GGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGC
+
=??DDDDDHHFDFGIGGIIGIJJJGIJIIIII9EHGGHGGIIIIJJJGIGIEIBFHIIIGGIEHD9>BDDCDDDDDCDCDDDDBDCDDBDDDDDDCDCDBC
@3XO
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
CC@FDFFFFFHFDHHIIJGJJJJFHHIHHGGCGIIGIJJJIIDDHIIJJIGIGIIJGIJJJHHH=BDEEEEDEEDCCDDCDDBDBDDDDDDDDCCDEDDDD
@3XP
CATCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGGAGTATAACCAGGGGGAGGCTGTGCATAAGAAGTTGCATAGGCGGGC
+
11144+22+=A<F9EAB:3A<+AGGF>?:):::9:<*?9?BGG65595(3@C>(((++3::C:(4+(&09)0&22(+(4(+44:(4(++44(4:(:(00&0
@3XQ
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAAC
+
CC@FFDDFHHHCFHIJJJJJJJJFHIHHIFHIJJJJJJJJJJJJIJJJJJJJJJJJJJIJJJIHHHFFFFEEEEEEDDDDDDDDDDDDDDDDCCDDEEEED
@3XR
CTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGGGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTG
+
@<@?DBD?A::<C4:A:2AI>:FG<@?CGB:CCGFFI>F>FD>)09?/9DB(.;@FIIFFB='5=<8?@>>;@@95,,::A??B)58@B:AB94<A@3+>A
@3XS
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
BB?DFFFFHHHHHJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJIJJJJIJJJJJJJJJJJJJJJGIHHHHHFFFFEFFDDD;@DDBDDDEDDCDDDDDDD
@3XT
GGGACACGAAGTCTCCACTGGTGCAGAAAGCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCC
+
BC<DDFFFHHHHHJJJJJJJJHIJJJJJJJJJJIIJJJJIJJJJJJIIJJIJJIJJJIIHHHHFFFFFEEEEEEDDDD5538=@BDDDDDDDDDDDDDDDD
@3XU
GTATCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTG
+
:B14BDEFHHHHGJJJJJJIJJJJIIJCGIGJJJJJJIJJJJIIJJJIIJJJHJJJHHHFFDDDDDDDD?CCDDDDDCDDDDDDDEDEDDDDBDBDDDBDD
@3XV
ATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATAAAGAGTAGGATATTCACATGTC
+
@B@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJHIJJJJJJEHHHHHFFFFFDE(;CEDDDDDDDDDDFEEDCDDED
@3XW
GGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTG
+
?@1ABDDDHHHFHHIGHGIIGIIJJ8?BGDFFEHIJGHDFFHGHHDGHEHBF=EHICHGI@F@@GGGII@E=CDBDF<?@CEEDDDBBBDBB?B>BDB3>
@3XX
GGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATACACATTTTAATATATTCTCCTTC
+
@@<DFFFFHHHHGIJIIJJJIIJJIIIJIJJJJJJJJJDIIJJGIJJGIIGIIGHIIICGHIGJJIIJEHF>BBD@BD(>CACDEEEDDEEEDDEEDDDDC
@3XY
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
@<@D1@DAFFFDDBGDDEHHHIII<?:CFA?BB<A;F?DFFABDFEEBBFF@BFE=@EE96?;>B@A3>@A-;?9:@@3::,>9(:3392<8(+>>@:AB
@3XZ
CTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATGTCCAGCAGAGACAGGAGATTCT
+
??1ADBDDHDBHHFF<<C??BFBDEHGIGG@@9AFB:?FIGHGBFFEDDECH>?F??;@/BB.8BFC=;FG@:=@=??)77=A;BE2?B;A>==5?;>C@@
@3Y0
GCGTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTTTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGTAAGAGTTT
+
:1+4=@BBAFB8C<FF@?FF4AFABCEEEHCEFE@?FAB>D>?49?<=/==FCDEE'9=/?ABABBBB344+4:>A:?+++43>>:<883>:(4:ABA+4>
@3Y1
CGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCC
+
CCCFFDFFHHHHHIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIHFDDDDDDDDDDDDDDDD:AB>ACDDDDEDDDEDDDDDDDDDDDDDDDDDDDDDD
@3Y2
GCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTC
+
CCCFFDDDHHHHHIIJJJJJJJJJJJJJIGIJJJJJJJJGJJJJJJJJJJJJJJJJJJJJIJJIIJJJJIJJIJJJJJJJJJJJHHHHGFFFDDDEEDCC
@3Y3
GTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGA
+
B@BFFDFFHHHHHJJJJJGJJIJJJJIJFHJJIJJJJJJJIGHJJJIJJJJJIIIIIJGIHIIIJJHGHH?DFFFFFFCEDEEEDDDDDDDDDBBDDDDD
@3Y4
CTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTC
+
@@@DFFFFHFFFFIEIIGAGHHHGIIIJ@EFIJGGIIIIGEGHIEHGHDHIEGGGIIDGHIIEII@BFDGIGHIJJIGGIIJJHHFHGFEF;BCDDFEFEA
@3Y5
TGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTGTTCTGC
+
@@@BDFFDFHHHHCHIBBGEHHGHGE>@CFFCFFEHIHGIIIIIHCHEHICHIIIIII@EGIIDHHHEACDD>@EFCCEEEEEDDCDDDDDBDDDBDDEDC
@3Y6
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
@B@FFFFFHHHHHIJJJJJJJJIJJJJJJJJHIIJJHIJJJJJIJJJJJJJJIJJJJJJJHHHHFEFFFFEEDDDDDDCCDDDDDDEDEDDDDDDDDDDD
@3Y7
CGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJHHIIJJJJJJJJIJHHJJJJJJJJJJJJJJJJJIJJHIJJHHFFFCFEEEEEDDDDDDDDACDDCDDD<CDD
@3Y8
GCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGC
+
CCCFFFFFHHHHHJJEIJJJJJJFHHIJJIJJJJJIIJIJJJJJJGHJJJJJGHHIJJJJJJJJJJJJJGFHGEHFF;ACDDCDDDDD?BCDDCDDDDDDD
@3Y9
CATAGCAGCACTCCAAAGGACCATGTGTCTGTTTTAGAAGTGAATATTCCTTCCATGAAGGCCTCTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCC
+
@<@?D<:=CBCFHFHGGBAG@;3FH9ACHFCH@??FHIIFD@DGF@<?B9?F>;BFD8DHEGGH;FCFA/=85@CC>6;->C5;;(5<?@?3599C:?C18
@3YA
TGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTG
+
<@@D=ADDFHAHFB@>GGGECIGF<BEEHDHIEBFBFHHEGDG<C8D;?*:BFHIGGIAADGEG>DFBH>CEGCF;CD@C@CAC>EBBC?BCA@@CCC@@;
@3YB
CCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATT
+
CC@FFFFFGHHHGIJJJJJJJIIIGIGJIJJJJJIJJHHGIJIIJJJJJIIJJJGEGIIJJIJHIIIIJJJJIJIIJJGJJJJJDAEHHGHFFFFFFFFEE
@3YC
TGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGAC
+
?=?;DDD?DBDACFBGEFDHIGFBHIIIGGGGHBDFGHIGECCBB;;>?5?BCBBBB5<BBBBCB?7@B?ABBBBBBB?B<>:@CCCCD@>@>ACC<3<>B
@3YD
CTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGAC
+
CC@DFDDFHFHDHJJJIHIJJJJJGJJJJHIIIJIIJCHIJHIJIDGEIIGGGHIEGGIJJEHIGHGHFFFCECCAC@CCDD@CCDDDCDDDCDDDDD@C
@3YE
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFFFFFHHHHHIJJJJGHHIIIJJJIJJIJJJJIJJIGIJJJGJIIFIGGGIJ8;FHIJAEHFHGBDFFFFAEEAAD;CCDEDCDCDDDDDDDDDDCD
@3YF
GTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCC
+
@BCFFFFFGDHHGJJJJJGIHIHIJI:CFHGIIIJJJFHIJJHIJJJJJJJJJJIJJJJBHHHHHFFFFDCEEDEDDDDDDDDDDDDEDDEECDDDDDDD
@3YG
CCCCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGC
+
@;?DDDDDFFFABFDG>CEEF?FHCFG@EGFEFIFEFFEFCD??DDGDBBBB@>FGEAE:BFFCFFFEIIBECCEFF=>AEDBBDDACCCCBB>A@A@BBB
@3YH
ATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATC
+
CCCFFFFFHHHHHJJJJHIHIJJJJJJJJJIJIJJJJJIIJJJIJDHGHJIHGIIJJJIJJGIJJHJJJIJJJJJJIIJHHHHHHFFFFFEEDEEDDDDED
@3YI
CGGCCACCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGGCC
+
@<@FDDDAFFH+AFHGHGJHGGHIIIBH?FGIEEEEGHHIEI6@DFDHI<BFHEGECDDBBDDB@DBBDBBBDD9<<>@CCCCCDDD<5<BDD9BD05?
@3YJ
CCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACC
+
CCCFFFFFHHHHHJJJGIIJIFIGIJHHIJGJIIIJJGIJJGGGHGBHIJJJJ@GIEIIIJJ@GHHHBBDEECE@DEDDDDDDC?B8ACDEEDDDDDDD
@3YK
ATTTCTTTTTCCCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTC
+
??@DADDEHHCDFDFHAHI?GAACEEEFBHHHF@9?DDFAHI><?GAGHIGDDHDDHGGGEEFE=@C@HGHIIGIGEHHHFDFFDE>6>@C@@@CACCCC>
@3YL
GTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGG
+
CCCFFFFFHHHGHIEHIJHIIJJIJGJIHHIIIIIJIHGIJJJJIIJIGIHIGIGGHGI@CHIJDGIHHGEEEFFEDDEDDDDDD?CCDDDDDCDDCDCCD
@3YM
GGCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
@CCFFFFFHHHDFGHIGIIIIIIJIJIEFFGGIIJJJIJGJHIJJJJIIHIJJIIGIJJJJGIHIIIHHF;B@DCDEECEDDDCDDD?CDDDDDD<ABDCC
@3YN
GTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCT
+
@@@DFDDFFHFHFHGIJHIIIJJJJGBGHHEGHGGIIJDGFHIJJIFIEGHGGFH@GGIHIIGIJJIFIGFHHEHECDDEDFAAEDABDDDDDDD?ACCDC
@3YO
CTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATG
+
CCCFFFFFHHHHHJIFHIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJIJIJJJJJIJJJJJJJJJJJJJIJHHHHHHFFFFFFFEEEEEEEDDD
@3YP
GCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGG
+
@CCFFDDBFHFHGAFGEGHGIGGDEGGEE?DBFHGGGBGGHEIGGH@A@FCGGI>EI7CHECAHEFFCEEDCDCDDCA@CDCCCCDCDDD@>CDDDACCBD
@3YQ
GTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTC
+
C@CFFFFFHHGHHJJJJJJJJJJIJIFHIJJIJHJJJJEHGFFFFFEEDEEEACDDDDDDDDD=ABB>BDDBDD8ACBDDDDDDDDBDDDDD>BBDD@@CC
@3YR
CAAAAATTCCCTGTTTTCTTGTTAGCGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTG
+
?;<D73ADD:AAB<:CEEE>CA<<,+11::3?D<D<:D0*8?*?BCEI@BCED@447))))7?C;=:9</,(.63>5-35;(-;AD(,;;>:((5:9><9
@3YS
GTGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCTCAGACATGTCTCAC
+
B?BFFFFFHHHHGJJJIJIJJIJJJJJJJIJJIJJJGJJIBBFDHIJIIIIJJJJIHHHHHFFFFFFECEEEEDDCCDCDDDDDACDDDDDDDDDEDEDEA
@3YT
CTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCT
+
@@@DDDDEFFDFBDDFEHCEIHIGG>FHHJEIECFHIGJIGIIFHIGIGGHGHH4@DEDCE=CHFDFAA?B?C@CAACDC:@CA?CCCCCCDDCDDDAAAC
@3YU
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJHIHHHHHFFFFFFFDDD9=BDBDDDEDDDDDDDDDD
@3YV
GACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCT
+
@@<DDAD?FDAA=E9EHAHEGGEGHEFH?B4CGHIEAGFG@?FCHDHG@EGF@DFEDBAFH@FGDHEGHG@=>7?=;37@DA<@B?=BB@ACCBA>9><<@
@3YW
GCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCC
+
CCCFFFFFHHHGHJJJJJHIIIIJJJJJJJJJJJIIJIIIIHJIJJ?DFHIJJJIJJJJIIJFHGHFFFEFFECEEEEDDEDDDDDCCDDCDDDDDDDDDD
@3YX
GGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGG
+
BBCDDFFFHHHHDHIIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJIIJJJJJJHGJJIHHHHHHHFFFFFDEEEEEDDDDDDDDDEEDDDD
@3YY
CAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGC
+
BB@FFFFFDFHGHIIIIGIIJIJGIJJJJJGJIJIJJJGGIGIHIGIIJJJJG?HFHIJGIGFHIJJJJIJJJJEEGHHHFHHGHEEDFDDEAABECCA@C
@3YZ
CTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACA
+
@C@FFFFFGHHHHJJIJJJJJJJJIJIJJJIGIJIJIJIGIGIIIGIJJJIIJJJJJJJIJJIJJJJJIHHFFFFFDCEEDD;??BDDDDDAACBDDDDD
@3Z0
GTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCC
+
@@@FFFFFADDDDABDGIJIIFHGHFGFHGGGIIGGIGG676BCCCACDDCC9>CDEDDDB@CC@DDDDA(<CCDCCCCCDDCCCACDCCACBD505AAAA
@3Z1
GTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGT
+
@@CFFFFFHHHHHJIIIJJJJJIIIJJJJJJIIIDGHIJJJJIJJJJJJJJIJJJJJJJJJJJJHHFFFFDDDBDDDDDBDDDDDDDDDDDDDDDDDDDDB
@3Z2
TATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGA
+
CC@FFFFFHGHHHGIJJJIIGIIJJGHGGHJGIFHGHIFIIGIGGEGDFHGIIIECFHGAEGAHAAEFHFFFDCCDEAEEDDCDBCDBBDDD>CCDDDC
@3Z3
GGTGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCT
+
BCBFFFDFHHHHHJJJJJJJJJGIIJJJJJJJJJJJJJJJJJJJJHHHFFFFFEEEEEEDDDDDBD@DDDDDDDDDDDDCD:AB>CCDDDDDDDDEDDDDD
@3Z4
GCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTT
+
?+?D?BD?D?D:CBEAEE<BEFEBF>A+AEEABBEEE@D1B@BB@D<D9??8?9=BBD>B=4:(=@;.)?@;.>6;(((55-;>A>AA5:A,55;>AA>4:
@3Z5
CACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACC
+
CCCFFFFFHHHHHJJIIJJJJJJJIJIIJJJJJIJJJJFHIJJJIJJJFGGHJJJJJJIJJJIIJJIGHHHHHFFFFFFFEEEEEEDDDDDEDDEEDDDD
@3Z6
CTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
??;BDADDACA3A?EAE=GGIB>G?>9?:::86@F7?FG@DB<8(((5=3==;>ECHB>9<5;(5;55(5@3:,,8<@<>:A@@ACA:<C>ACA@<?ACC
@3Z7
CCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTTCCAGGGGCACAATGGGGACCAGTTGAGCAACTGGTGGTGGAGGCTGAGGCGGAAGGCCTGGAGGAC
+
CC@FFFFFFFHHGIIEAGHJGHJDIIHIGHIJIJIEGGJIIJJIJJJJJJIJHIIHHHHHFFFFFEEEC6?B;@BBDDDDDDDBBDDBD<?BDDDB?BDDD
@3Z8
GGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCT
+
???DAA;AADDE4:<A:ACFF:33<::+A;E?A?E?CE>11C4C?DDB99)0?389?<*/)=BCIID==@7A=@.)=.)?;);;;;>>6(.66.5>>A?A
@3Z9
CTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAAT
+
@CCFFFDEGHHHHJJJJJJJJJIIJJJJIIJHIIIJJJJJJIJJJJJJJJJJJJJJJJJIJIIJJJIICGIHHIJHHHFFFFEEEEEEEDDDDDDDEEDDE
@3ZA
GGCAGCATGGCACAGCCTCCCTTTCTATAGTAGCTCGCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGGCCACTCTTCCAGGGCCTGGAC
+
8?@DBB>D<BDH>;?DGG>FGF<FDBHBHIF<:?C>?:?DE;FG4BFA/?BAFGGG<C9CAH78?9,.(;5;>C;@CCCCCC@:,>@@3::397(208?(
@3ZB
CCCAGGGAGACAGTTAACAAAGAGACAGACAGACAGAGGAACCCAGCAAGTTCTGGGAGTGCCGTCTCTGGGCTCTAGCATCCTGGACACAGGACCGAGCT
+
CCCFFFFDGFHGHJJJJJJJIGIJJJJJJJJJJIJJIHGJJJIJIGHJIICGHHJJIII;@EHHHFFFEEDCDCDDDCCDEDDDDDDDDDDDDDDDBBDDD
@3ZC
GTGTTAAAGACCAACCACTAACTAAGAGACTTTCCAAGTTGGGCATATGCCAAGAGTCCAGACTCTCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCT
+
@@@DDFFFHHHHHIIIGGGGHEIHIJJJIGIJIJIIIJHHIIEHIJJIIIEEGICGBFGCCFHGJJIJIHFHGHHFFEDBCACCDD?BDDDDDDD>CCDDD
@3ZD
TTAACTATCAAACGTGTCCATTAATTTTGCCGCTGAGGGTGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGGAAACCCAGTGTTAGTGC
+
CC@FFFFFHHHHHIGIIJJJJJJIJJJJJJJJJJJJJJJGHJJJIJJJJJJJJJJIJJJJJIJIJJJJIHHHHHHFFFFFFFEEEEEEDDDDCDEFDDDDD
@3ZE
GCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGT
+
@?;DDDDDHADFDGG?CFFEA>@FBB>FFGGGGB??9CGHGHEGEFGDFH@GBBFHEGEFH==F;7=@@GECD>GH;A??)=C7??C@>@AB>>@@AA>C-
@3ZF
CTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
?@@?DDFFGGHFHHIGIJJI@EGHGHIHIGGFHIDGIJIFGGHGIGIDHEHIJHEHHHHFFFFFEED>CCDEDDDCCDDDDDDDEDDDDDDCDDD?BDDDD
@3ZG
CCGCCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTAT
+
@@@?DDDFCCDFBFGBBBEEHGFCEFFFBFHGGGE??DH0?@FHIIDFHGEHGCDBB9@BDDDDD08@BBB>BDCDDDEDC<BD5<BDB>&05<CCCC>AD
@3ZH
GAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
CCCFFFFFHHHHHJJJIJJJJEHIIJJHIJJJJJJJJJJGHJDGIFHJJIJJJJJJJIJJGIHHHHHHFFFFDDCEDDDDDDDDDDDDEEDDDDDDDDDD
@3ZI
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGCAGG
+
@8?;DD>???AAFHG;CEB>AEB:):DD9?DGGGB<67?B<B<==C..))/=@A:EA?>BE7@;;;:;>AC?CCCC:@D@C(:5>>C3(2:?2(4?((+8
@3ZJ
GTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAAT
+
@?=DDDDAHH?CFD:?<CAIADHHHBHHIII<A?CHH9CGIBGDHCHIGD?D<FFDDBDH@HGICGCHGG>GICEGD>EAEHAEA@?>BDEABC>CCC?CC
@3ZK
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTG
+
@@@DDD?D?FFF;FBGDGFFEFEBF<GFDEFE>@FEIFCFAFIFFEE9B9;CFEC7CEEEECEFD,9:,>@@B>><@B??ABBABBBBBBBBBBBBBBBB>
@3ZL
CCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCAT
+
CCCFFFFFFHHHHJIJJJJJJJJJJJJJJGHIJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJHHHHHFFFFFFEEDDCDDDDDDCDDEE
@3ZM
GCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGAT
+
=??D=DB3=DD>,2<C4EF@EADD?DECBBAAAECCDDDDDDD9?39BDCBDADADDEACDECB@>)=C@C;7@=??CDD@;;A2@@<.6=;',81:555>
@3ZN
TTCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAAC
+
@@@FDF?DHHBDHGIJGHJIJGFFHGJJJIGIHIIGGGIGIIJJE@GIACCHGGEHGIGFHEFFDDCDDBCDDDDCCCCDDD3995CDCCACDBBD@CDDD
@3ZO
TCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTT
+
@?@FDDFDBFHHFAEEHDDFGHIIGG9CFDDHIJIJGEGHIGHFEHCED?CBB??A@CACC@CCACDDCDDCC@>CA@>C>A>@CCEEDDEDACCCBA<AB
@3ZP
AATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGG
+
@@@FFFFFHHHHHIGIHHGGGGIGHGIEGHGFIIIJJEHIIJIFHHIHJJGIIIHJIIIJIIICAHGCHGFFDDDDDDDDDDDDDDDDACCCBBDBDDDD
@3ZQ
TGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGT
+
CB@FFFFFHHHHHJJJJJJGIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJHHHHHFFFFFD=@DBDDDDCDDDDDDDDDDDDDDDDDDDDDD
@3ZR
CCTCAGTACTTAAATTTTAAAAGAATAAAACAAATGAGTTGTGGTTAAAATTACAACAGATTCCACTCTAACAGCAATGTCTCTAGGTACAGAAGGCATA
+
CC@FFFDDHHHHHJIJJJJJIJJFGJJJJIIJHIIJJIGGGDHIJIIIIJJJGIJJJJJJIJJGIJIJFIJIJIGJHFFHHEHFFFDBCCEEECCBDDDD
@3ZS
CTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCT
+
CCCFFFFFHHHHHJJJJJJJJHHGHIJJJJJJJJJJJJIJJJJJJJJJJIJJJJHIIJJJJJJJJJJJJHIJJJJJJJJJHHHHHFFFFFFEDEEEDDEDD
@3ZT
CGTGTTTGAGAGTTGGAACCATGGCTGCTTTCCATAGGTGAAGATCTCCCAGAGGATCACCCCGAAGCTCCATACATCACTCTCTGTAGTGAACTTCCGGT
+
?@@?BDDDAH?<<<AEDEGGGGGEEBEEHHGFAC@CHCG3BDD9DDHHEHIIICEC8=FHGGGEEEHFB>CAAECECC@ACA>@CC@CADADC>:@CC@B0
@3ZU
GTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGC
+
CCCFFFFFHHHHHJJIGIJJJJJIJJJJJJJIIJJJJJJJJJJJJJJJJJIJJIJJJJJJJ=FHHHIJGIGHHHHHHFFFFFDEDDDDDDDBDD9@BCDDD
@3ZV
GCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAAT
+
CC@FFDDDHHH<CFGGIIGIBHCGIEHGIJGGCGGIIIJIHGJIGIFGFHIGGFGHIJIJJEGGCEHF>BA>CCCCBBDD<A<CCACACDDDDCBD9@@CD
@3ZW
GTCGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
CCCFFFFFHHHHHJJJCHIJGJJJCGIJJJJJJJJGHHJJHJJJJJJJJJJJJJJJJAEHHFFFFFEDCEEDDDDDDDDDDDDDDFDEEEDDDDDDDDDE
@3ZX
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTT
+
@@@FDEFDFFDFAGGHGEGIIGIIIIIHG<GGHIIIIEGBFHG>@FFHBFHGIIIFIIIH=AEFFFFDDFFCCEC;ACBB?>A@C@CDDDCC:A@CACDDD
@3ZY
TTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGC
+
@@@DDDFFFDFFDHCFHIIGFHI?FGIGJIGGHJJIJEEGD;DBD?CHDHHECF>EIIJIJHHEA>D?>?6;>CCCDCCADDCBCC:AACCCDDDDDDC@8
@3ZZ
CTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAAT
+
??;AA+2B<DD<D<E:<AFC?EAFF>A?CECE@9:?EB9?:DDDB9B?:??BB<99998??D8.BBBDAE@;8====7@DD>?CDD?;;@?AAA6;-;A;A
@400
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAT
+
CCCFFFFFHGHHFIJJGIJJJJIJJJIGHIIIJHIJJGBDHFGGIGEEIJJIJJJEIJJIIIGFDHIHHGBD@DCACECCDDCDCDD9ACD>ABD2?BDCC
@401
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGT
+
@@7DDDDDHFHHHIG<CFHIIHHIGIIHCFG??BFGFHII@??FGI8==FGFFCF67==AEG=AH@EBD@?CDC>@A?A??A?C9C5;@@CCCA>>@CCCC
@402
CTAGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAAC
+
@@@DFDDFHHHHHIJJJIJJIJJGGGCFHFGIGGIJJJIJJJJGHIIJJIIIIJJIIJIGIIIJJHHFGEFEFFEEEECDDDDBDDDDDDDDDDC@CDEED
@403
GTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGC
+
@??DDBBDFFHH??E?G><A:CEGGIGCGA;C1?EDF<0?@@GEEBDD@DE9>;;=33=B?C;;=@>?CADCAC<?CC34@@C>@>A@>+:>A>:9:?CB?
@404
ATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTC
+
CCCFFFFFHGADFHIIJIHGHJJIICHHEDFGIJIIIJIIIIGIIHIIJJGIJJIJICHGIIGJJGHGHHFDEFFFDEEEEECD;>CDDDDDEDDDDDD@C
@405
GCCACTTGCAGGGGGCTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTT
+
CCCFFFFFHHHFHGAGIGGIGDGGFGHGEGEGHIGHEGGGEFHEBDDDFECECCCCDDDDDDDDDCCBBDDB@DCBCB<ABDDDD>B9?CCCCD???CC>C
@406
GTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACT
+
CCCFFFFFHHHHHJJJJJIHHFHJJIJJJJJGIIGHIHIJIJJJJJJJJJJJIJIJJJIJJJJJIIIGIJCHHFHHAHFDFFFFEDEEEEEDDDDEEDDDD
@407
GTTTGCATATCTCCTGATGCAGTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJIIJJJJJJJJJJJJJJJJIIIJJJIJJJJJJJJHHHEHFFFFFFEEEEEEDDD;@DDBDDDE
@408
CTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGG
+
?@1BDDFFFDFFHIGAGIIIIGIIFGHGHGGHEIIIGIIIII@C7DHHHEEECFFD??';CCDDDB;@DDBAC4>BCCCCCAC>CDDDCDDCCCDDCDB7?
@409
CCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCC
+
@@?BDDDDBCDBFHGIDGHGHAHDFHGGGGGGIEIIEGGGIGGFHIIIDGGIIFHHEHGGHEABFBFEEEDD>>;?BDDDDD@BBBCCBB@B?B>ADCCC
@40A
CCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTT
+
@CCFFFFFGHHHHCECGHGIJJJIJEHEHIJIJJJJGHIHHIIHIIJIHJIHIJJIJJIJEIJDGIIJJIHHGFHGEHHFFFEFFADEEEEDDDDDDDBD
@40B
AGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTG
+
@B@FFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJHJJIJJJJJJJJEHHHHFDFFDFEEEEEEDDDD=CCEEDCDDDDDDDDED
@40C
CTCCGGTTCTCTCCTGGTCCGGAAAATCCGCCAGACTCCTGCCCATAAACACCCAGGCTACTGGGGGGGTCCTGTCGTAATGAACTCTGCTGCCCGTATCT
+
???A1D=D:DD>:A4:++3A1<?CE3*1*)::D69?39?*.==B@@;=;C)65:5((66;@>@;??/5&))2(4>4((((++(:4>>:444>>2290518>
@40D
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
@@@DDD?DFHHHHGGDGFHBEHEFGFGG?EHFGHGIGFGHIAF@FDFHEHICHIGD=DEHEEHEDE@;CC;@>>A@>2;;>CCCC:>?99?BCCCCCCAAA
@40E
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTG
+
CCCFFFFFHGHHHIIJJJJGHIJJJJJJJJJJIJIHIJJJJJHIJHIJIJJJIJJIJJJJIJJJJHHHHFFFFFFEEEDDD@BBDDDDDDACCDDDDDDDD
@40F
CTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAAC
+
@@@DFFFFHDHGHJGGEHGHEIGHIIJGIHGIGGIGGGHGIGGHGIJIEAHII@HIGHIIGIIGGGCC?CHFHFFDFFDDCE;@CCCCCDDCCACCCCDDC
@40G
CTTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTG
+
CCCFFFFFHHHHHJJJJJJJJJJHIJJJJJJJJJIJJJJIIJIJJHHHFFFEEDDDDDDDDDDDD<ACCFFFEEEDDDDDDDDDDDDDDDDEDDDDDDDDD
@40H
CCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATT
+
@@@DDDDDHHDDHIIIIGHIIGGCHHHEFGGGGH@FCAEGEGGIIIIIIGCCHGGEFH@DBFHEDEHIGEHAGGHIGHH@DFECEE@C>CCDACDEEECCD
@40I
CACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCA
+
@@@FFFFFFFGFHGIIJIIJJJIIIIIIIJJJJJJJJJJJJJIJGJJIJGHGHJIIGIIIHEHFHHFFFCBFDEEDDDDDDDC?BDDCDDDEDEDDDDDD
@40J
ATGAGATGTGCCTCCTTCAGGAATTCAATCTTCTCCTGGTCTGTGGAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTA
+
??+==ADAAADFF@?;CGGA93:CF<F?CBB>A:1*?C3?CFGGEHGGHG?GH>FF:*BFF8=FC47@FC3===DHIIBAC??>C337;?;>AC@AAACC
@40K
CCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCC
+
BCBFFFFFHHHHHJJJJJJIJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFDDEDEDDDDDEDDDDEDEDEDDDDDDCD
@40L
CTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTGTTCT
+
CCCFFDEFGHHHHJJJJGIJJGGEFHIIJHHIJIIIJJIJIJJJJIHCIIJJJIHIJJJIGIJHHHEHFFFF@BBCCCCCEDDDDDDCCDDDDADDDDDDD
@40M
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGAATAGCTGACATCAGTGGGCTGTCC
+
@@<?;D:ACD:CDG;<8;C<C<2<+ABFF>1*?D<GFIIFC<:-'7.7@;FEEFCD:A()=.;?.7@B3>(.-;=5(5(>@(5:>?B:@>>@:?2<?@+::
@40N
GGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATT
+
CCCFFFFFHHHHHJJIJIIJJJJJJJJJJJJJJJJJIIIJJFHIJIJGIGHGBIJJJIHJJJIGIIIJJFEEEHEGFFEFFFFCDDDDCDEFFEDDDCDCD
@40O
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGT
+
@@@FD?DBDFFHFFFHIJIBFHEBEEGEGHGGGGHGDHIIJIGEIGIIGIGI@EHIEIFEHFDFDEFECCAEEDDDD=CCDDDDD9:>CDDCDCC3>>@>4
@40P
CAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTC
+
==?D?;DDBBCFBAHAHGDDDDAAE>BC@A@DFD?B<?D?DHIFHI@FHIGIGEGI@???;=?A>@>BAAAA>C:;AACCBC@>:5:5>;<+8<<@C@A
@40Q
CTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
C@CFFFFFDFHHHJGGIIJIJJIJIJICGIJJJJJHHIIIJJGEHCHIJJJHHHHHHFFDCDEDACCDCD>ACDDDDDDCDDDDDDACBACCCCCDDDCC
@40R
GTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACG
+
@@@FFFFFFHHHHJJJGGCEHIGIJGJHGIJGHFHEHFDGIIEGHIHGGHIDHIIIIJJIJDD)5?A@C??ADCD@CD:>C<@<>ACDDDDCCDCCC@BD
@40S
GAAAGCTTTGGCTGGCCGCACTGCCAACCATGGAGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGCGGGAAGGGGATGTTTGGC
+
<@@DD;?AF4DB<E?;A81CF)*1:<DGEFE<3*9D;*00BF@DBD8<CFFIIFIBEBDDDD@>@>>AAABA@>@?A:@@B<())&9-0(00&5<4(49(+
@40T
CGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTG
+
@@@BDDDDDHHHFGI>FGIIIFHIEHIIIGIIIIGHIGHGHGGGIIIIIIIIIIIIIIIIIIIFHEHHFFEEEEECBBB@BCCCCCC4?C4@CDECCCB:@
@40U
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGC
+
CCCFFDDDHHHHHJJIJJJHIJJJIIJJJIJJJIJJJJJJJHIIIJIJFGBGHHIJIJIJJJIIIGGIJ@EHF?CCDCECBCDD=BDDDCDDCDDDDDDD
@40V
CTAAAACATTCTTTCCTCTTTTGTTGGATGGGAAATTCCATTCTGTTCCACATCAGCTTATGCATTGGAAATTTTGTATCTTTAAAAAAAGATTTGAGGA
+
@B@FFFFFHHFHHJJJJIJJJJGJIJJJIJIJGGHHIJGJGGGCIJJIJJEIJJJIIJIJIIJJJJJJIIIIJIGEEGGIHHFHHHHFDDDDDDDDDBDD
@40W
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
CBCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJIJJJIJJJJIIJIJJJJJHIJGEHGGHHFFFFD@CDEEDDDDDDDDDDDDDDDDDDDDDECDDCCCD
@40X
GTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGAT
+
CCCFFFFFHHFFHFHIJJJCFHJJJHHIJJJJJFHIIJHHHFFFDDDDBDEEDDDDDCCDDDDDEDDDDDDADDDCDDDDDDDDDCDDDDDDDDDDBDDDD
@40Y
GTGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
BB@FFFFFHHHH8EHIJJJJJJJGJIIFHIJ@FHIHIJJJJJDGIJJIIJJJJJJJJJJJJJJH=EFFFFFDEED@CDDDDDDDDDDDDDDDEDDEEDDDD
@40Z
CTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATG
+
?@@<A?DDDDFDFEIF+AF@BAFFEEFEGFDFFB6@AEEACFDDE1?=CBB@B@>B>@;ABCBBBA3>A@>AB;A>>A:@ABB?3??@AB@B5<58@B<AB
@410
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTG
+
CCCFFFFFHHHHGJIJJJJJJIJJJJJJJJJJJIJJJJIJJJJJIJJIJIJJIIJJJJHHHHHGFFFEEEEEDCDDDD;?B>DDDDDDDDDDDDDDDDDDD
@411
ATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTCCATGATGTCAAC
+
@@@FDFFFHBBBHB@EFGEHICGHGFGECEHHGIIGIGCFHIEGHDHEIEHHIHGBGE=8B;CHHA7==:C?EEH>BB=ACD>>CB;@@AC>@@ACCD
@412
TGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGC
+
@CCFFFFFHGHHHGHIJGHJJIIHHIJJJJ@FHIIHHIIJJIJJJIJJIIJIHHHHHFFEFFCECCEEDCCDCDDDDDDDDDDDCDDDDDCDDDEDDDDDD
@413
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
C@CFFDDD?FFHHGGGHGIIIIIIIGIGIIIIIIIIHIHEGGGHCGIIIDCCCEEFFB9>A>CCDDDCDCDCD@DD>CDDCDDCDD>@:@CDDDBDCCCC
@414
TTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGC
+
CCCFFFFFHHHHHJFHIJJIJJJHIJJJIJJJJJJIJJJJJJJJJJJJJIJJIJJJIJJJJGHHHFFFFDACEEEDDDEDEDCDDDCDDDDDCDDDDDDDB
@415
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
@@@FDFADFHHFHAFGFFIEHDAEHGIIIIIGHIJBBFGGIIDHGIGGHIJIHDCFFHGBFFGFFGF-=CEBDEFCED;=@CACDACCDDDDDDDDCBD?5
@416
CACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTT
+
@@@DADBDHHBFDHDGGGGGIEGHGGGFDHIIHGHHIJE??BGHGHIGIGGIEAH@EEEBB?@@=AACCECDCA>CC@CCCCDC>8>C8A@CCDDCDCC:@
@417
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTG
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHHGFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@418
CCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGAT
+
@@<AABD?=2<AD;ECBFFD@H<<F@<?<AAGGBB?FD?F??9BDDGIIDB4FDF>(*.BBB)=7./)=F7477)=7.7==EE>>DDDB3.;;>>;5-;;@
@419
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCA
+
@@@DDDADFHFBFHEGG<FG>EFH?BHHEGFHGGBCCGGGGGGBHG8BBBDAFEHGGGIGHGEGEEHEHHEB@@7?@DC?A@?;@CCB?::555:@@CB@
@41A
GCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGC
+
1:=DB:@0@DB?FFBFEFFEGEFEEGIEEBB?*:*?8B<BF@FAFFIDFCE4CCA@DA>;=ADD>D>93>@ABA@>BBBB8@@@>@@BB>>:>BB?@<<<@
@41B
CCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTG
+
CCCFFFFDHHHHHIJJIGIIGEFDHIIJGHHGIIJGIEHIIIJGIIIIJJJJGIIGHIIIIIJJJJI@ACHCCEE?CCC@CDDCBD8<CCCCDDDDDDDDD
@41C
GGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAA
+
@@7DDDDDDADFAFHGBEHHGDHCGGFGEDGGCEHIHIIICH=FFHHI=CFG@7@DH@EHHE<<A@ACC?CCCCA?CB3>??ACA>@@>ACC@<BBBB
@41D
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@CFDFFFHHHHHIJJFHIHGIEHHJJJJJJJIJJJJJJJJJJIJJJJJJJGHIIJIIJJJJJGIIJGHHHHFFDDDDDCDDDCC>?CCDDEECCDDCDDD
@41E
CTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGT
+
?@?DDBDADFDBHIEAHIII>FEHFEHIE9CFGIIIIIIBHGGEEHC==CHI@@FCEHGA=AEHH@CCFDEFEC?C69?CCCCC>:CCCCC@BB2<BA<A8
@41F
AGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAG
+
CCCFFFFFHHFHHJJJJJJJJIJJJJIJJJJJJJJIJJJJJGJJJJJJIGIIGIGIJJGGIGHIIIHI=BGCGHCGHDHIJIIIJJIHHHHGH
@41G
CGGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGAGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGAAAGGCCGTCTCCGG
+
;<7:B:+ADD>4+:CEE3<4+<<FAF<C++2A?1*1?*?:C<@DD?*9:9??DDEE90*0B)8<4;@@1?7=?=<;AA36(((19;'&)+(+())0(+())
@41H
GCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
@C<DFFFFGGHHHIIGGHDHGHIIHGIGIIGIHIIGHGIIIIHGGFCGIIIHGHFIE<BBCC@CABBCCBBCCCCBBBBBCCCCCCCCCCCCCCCCECCC
@41I
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGAAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
;@?DDDDD?FFFBCAE:A<EEBHGGHC@E1?DH):BG<DFG;B=6C@CB8@;==@@EG=CAECED?,91>>>A??;?:@>>AC<?B009@CCC4:@>:CCC
@41J
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
BC@DFFFFHHHFHIJIIJJJJJJIJIFHIIIJJJJJJIJJJHIIJJJJJIJJJJJJJIJJJIJIJIJJJJJ=BHECDDFEDEEEEDDEDCCDCCDDDDDDD
@41K
CCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATC
+
@@@?DDD?FBDBDBF><C<:<CF:F?<2A<<<9?C<9C?1??D?FDAF?FE@FGIIIIBGI8B88BFFFG>FDFCC@CEA?CCE<7()..;6>;>6>B;A
@41L
TGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGGGGTCTCTCATCTCTTTTC
+
8?@+ADDDF;FF<FFFEDBD<GG?EEEFIIFGEEEBD>G>FBFFIIF?BDDDBCCCB>5>5;;=?/8-5>AABBBB?@?B3<(59))94+>AAAABAA>BA
@41M
GTGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJHHHFFFCEEDDDDDDBDDDDDACDDDDDDD<@BDEDDDDDDDDB
@41N
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
@@@FFDBDHFFBHJHIJJJIEGIEIJJGIGGHIIJGGGIJIJGIIEHIGGHEGIIEHHIGGHHEEDACCCDCCBBDBDDDDDCCDCDCADBDDBBB?CCDC
@41O
CTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACAAATCACATCGCCATCTTCACCTTCAAAGCTTTCATTTATGACT
+
?@?AA;:220<D?BGG@;F<FBFFF@B<FGCB9*?DDF?9:?DB?9?GFGICFFEG>BFIIII<=CFEE8C=C;3??;?B?@>@@(6(---;55@@(,(,5
@41P
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
BB8DDFFFHHHHHJJJJJJJJJJJJFHIHIJJJGIJJJJJJJJJJJJJIIIIJJJHHFFFFFEEDDEEDDDDDCDDDEEFEDDDDDDDDDDDDDDDDDDDD
@41Q
CAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTC
+
@@@DDD;DHFDB?EGHBEHBHIEHDGEDFA?FBGIBHCBH=FHG@G@CCEHEG>?EHHEE>CE;;;?:B=;?CCC:@CCCCCCCCCCCCCCCCC?CC9ACC
@41R
TGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCC
+
CCCFFFDDHHHHGJJJJJJIJJJIJJJJHIJIJIJJHHIJIJJHIIJJJIIJEHIGCHII5CEHCHHHHFF;ACCECCDDDDDDDDDDDCDDDDBDDDDDB
@41S
CGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCT
+
CCCFFFFFHHHHHJIJIJIHIIJJJJJJJJIJJGIJJJJJJEHJIJJGJFIJJIJJHHHHFFFFFDDCEDDDDDDDDDD39B5CDDDCC?DDDDCDDDDDD
@41T
GGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGC
+
???DD?DDDDDBDEEIB<+4CF3+A?FC9?C@:1*?:DDDD2*?*0?DBDI<@8BCIDEC@/=CDIE;7?CDD7@?A>/=83=????3)+5+::<>??
@41U
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
CCCFFFFFHHFFHJHJGIIJJIIIJCHHJGGHJ0?DGDHHIFHI?FEFIBFHHJJFGGGHHEHHFF<BDCEEDDDDD>ACCCDDDDDDDCDDDCDCCDEDC
@41V
CGGGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGCTCCT
+
?8=DD:;ADBDDD3<AEEIEI:FFCCCCEBE9?E<:9:11:?D>??;*?8BEDDDEBC))/88@@@EAEEI@@A<699@?AAA?8;??>A5:,535&))2(
@41W
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCC
+
CCCFFFFFHHHHHJIJJJJJHIIJJJJDHIEHEHIGGHFHGGIIJJJJJIIJJCEHIIJHHHHHFFFFFFFDDEDDDDDECDDACDDEEDDDDDDDDDDDD
@41X
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
B@:BBDFFHHHHHJJJIJIJJJJIJIJJJJIIIIJJJIIJIIIJFJJJJJIIJJJJJJJJJJJJJIHHEFHFFFFFEECCEEDDD;@DD>CDCDDDDCDD
@41Y
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
@@@DDDDDFDFFFGGGIEEGGGGHBFDBGGH)?CG?BDAEBE7BFEDGCHHIIFEIGIIJIGHF,91@>ACB@CBCDAC>ABDD1;CCACACDCCCCCCCC
@41Z
CCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTTT
+
@@<DDDEDFFBFFIFIGGHEGJHHGHGHEHHHDHGBEHGGIIIJJAFII@CHHDGIIJGIJIEHDHGHIGJHIIGHHACHHHEHEECECEFCFEDCACEDC
@420
AGGGCGGCTGCTGGGGCACAGGAGCCGGGGCCTGCTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTT
+
BC@FFFFFHGHHHIHIJJJJJJIJJJIJJGFFDDDEDDDDDCDDDDACCD>CD?BDDDDEDD>ACDDCDDDCDDCDDDDDDDDDDD>@BDDDDDDDDDDDD
@421
GCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACT
+
CCCFFFEFHHHHHJJJJIIIIJJIJIJJJJIIJIIJJJIJIJJIJIJJJJJJJJIIIIJJIIJIJJJHIJIJJIJJJIIIJFHHHFFFFDDEDEDDDDDDD
@422
ATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGCTTCTGATCAT
+
BB@DDFFFHHFFHJJIJJJJJGHJJJIIJJHIJJJGHIJJJJIIDHHJIIGIJGGGDEGFFDDD@BBBDDDBBDDDDDDEEDCDDDDDDDDDDDDCDDDEC
@423
ATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTAT
+
@<?BDFFDDFHFDIBFHIGIFHDEHHHHIIHGGGFGHIGIGA)@@FGGHIG8?FFHICFEHIIIIIIGEAEEDDDCCECDCCDCCCDCDCCC@CA??ACDD
@424
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
CBCFFFFFGHHHFGIIJJJJJJJJJJJJIJJJJJJJJJJJIJJJJIJJIJHHJJJJIJJJJJJJIJJJJIJJJ=BFFFFEEEEEEEDDEEDDDDDCDDDDD
@425
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGGAGGAT
+
@@@D=D?D<FF8<:?82CF>3C?CB<*?FFFIIE<?F<F>F?DF?DGBF8?B9CBF@FIF7.)8CEFFFEB@;A)>;>;@:@@>@BB9,:8(5;?&)55+9
@426
GGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTAT
+
@@??DDBDHFB<DCFEEC?<AIIGH?FEBFH<9?FB@9EF>C91C*0?9B@?9999?D>DHEC<9BGHGC@DDGHA;CGI=?AE77?@;AD@CD6>;>BC
@427
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJHJJJJJJJHHJIJJJJIJJIJJJJJJJGHHHFDDDEECEDDDDCCDDDDDDDDDDDDDDDCDDCDDDDDDDDDDDD
@428
CCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAAT
+
@B@DDFFFHHHHHIJJJJJJJJJJIJEHIIJJJJJJJIJJIIJJIJJJJIJJIJJJIJJIJJIJJJGGAEHFHHHGFFFFFDDDDDDDDDDDDDDDDADDE
@429
CCTGTTTGCACATAGTTTAACACATCAAGGTTGGAATGAGCTGGATAAGGCTGATGACCAAGAGTTAAAATCTCCCAAATCAGAATTCCAAAAGACCATAC
+
=?<DBDD8+AF?FD><:CCEDBE@+<:<EE2<F<*?1?<DF9BGGE>FDGG<B(/??*=8=F(=@DD;D;=DE@@E?3=>?B@B@@AAC@@A?>=;=95:?
@42A
GGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJHIJJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJHIJJJJJJJJJJHFHGHHHHFFFFFF
@42B
GCTGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGAAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTC
+
=?+BBBDDBA?::AC?CE?EB<FFGIA=3A?:D?DFBBDF@DF08<8B<B<F<FF?FF@EFECC=(,5B;;>;@A@5;@BABBBB?=?A@BA:>:>AABB@
@42C
TGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
@@<DBDDFGHHGGHJJJIJJJJJIIJJJIHIEIGGIIIJJJHIIJIJJJJJJJJJIGGIFIJJFEHFHFFBEFECCCCCCDCCDDCDDD:@CCDCDCDDD
@42D
CTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJIHHIJJJJJJJJJJJIIJJJJJJJIJJJJJIJIJJJHHHHFFDDCDDFDEDDDDDDDDDDDCDDD
@42E
TTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTG
+
@C;DDFFFHHHHHJJJJIJIJJGGJJIJJIJJJJJJJJJJJJJJJGIIJIJJJJJGHIJJJJHIIJIJIIHF=@BDCDDEDDDEDDDCDDDDDDDDDCB
@42F
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
@B@DFEFFHHHHHJJJIIIIJJJJJHIIJJJIFHIGGIIJJJJHIJJJJJJIFEHGHFFFFFEEEEEDDDDDDDCDDDDDDDDEDCDDDDDDDDDDEDDCD
@42G
CTTGGGTAATGCACTCAATGACCTCCGTGTTTGAGAGTTGGAACCATGGCTGCTTTCCATAGGTGAAGATCACCCAGAGGATCACCCCGAAGCTCCATAC
+
:?=4++=DD,<:<EB?E3+AEEF4A<8++:?:?*1:?DD>BBD@7D*9*?)?;=B@DEA4@.=C3=CC.7))).;?(..((;6;A>;;;,33->AA>AA?
@42H
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTG
+
@@?DDFFFHHGFHJIGIIEIJJIGIIIJJ@FHFHIGGHIIJIIIIIIJIIEIJJGGHHHFFFDCDCEADDDDDDDCBDCCCEEFDACDDCDDDDADDDDDB
@42I
GGTGCCTCAGGAGCAGGAGGTCTCTGGGCTTTACGCTGACGCCGGCGGGGGGCCCGTGTCTTGGAGGCTGCCTTCTTCGGAATGTACACTGGCTGCTGGC
+
1===ADBDHDDADEBEGGGGFGHIIGFGGIJJIJJJIFGIIJGBIIFB8<BB@DD8<<BACC@A:??<18?BCCCACAAB@B?C:@>4>>>AB9?<C3:<
@42J
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAG
+
CC@FFFFFHHHGHFHIJGJJJIJJIJJGFHGJJIJIJJJJJJJDFHIIIJJJJIJIIJJJJJJJIJJJJJJII=BFEFFECEEEEEDDEEDDDD
@42K
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
@@@DFDD?HHHHFIBEHFGCCEEGHGHIGIIGIECFGGI>;;D@FC9B?FFBBC=)<A4@G5;>AA??BBD>@C@A@A?;AAC@CACCC<<ABBCCACA@
@42L
GTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGC
+
;??BDDDB3A:CBEB:<A:<;C@3A>FIC4A29:))1:C4??3;???DD@2?(/7B@CACEAD:AEA=AC7?==A?A>A3;1.;@=>63'3,,(&))95.
@42M
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJJIIJJJIJJJJJJIJJJFHGHJJJJJJIJJIGHIIJJJJJJJJJJJJJJJJJJJJHHHFFEEEEEDEDBDDDDDDDDAADDCCDD2
@42N
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGT
+
B@?DDFEFHHHHHJIJJJIJJFHIJEGHJ?EGIHJJIJJJDGGIJHJJJJJJJJJJJJJIIIBHHFFFFFEEDCEEDDDDDDCBCDDDDDEDEEEDDDDDD
@42O
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACT
+
CC@FFFFFHHHHHJIJJJJJJHIJJJJJJJJJJIJJJJJJIJJJJJJJJJJJHHHHHFFFDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDD
@42P
GTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCAT
+
@@@DBDDDAFHDHG<FB@GE>CB;EFCBGHEHI8?CB?BGHH?DGDHGG@BA@89?CF==CC7=FGCF7=';::=B7;;?@BB@;ACCAC:AA;CCC@CC@
@42Q
GGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTT
+
B@@FFFBDHHHHHJEGI<FGIGGHGICIIIGIIIJIJIIIHIJIJIIJJI@FHJIJIJHHHHFFFDFFFEEEEEDEDDDDDFDDDEEDDDDDDBBDDDDCD
@42R
GCCATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCT
+
1?1==BA;:D=CDA<+A:A:AGCFE2+<FH499CG91::C:608D:@;FCFID7@=;@;B=;B76>@>=55;@>C;:,>:3>5<3:5@C:AC::::>C@:>
@42S
TTTATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTG
+
BCBFFFFFHHHDHGHIHIJFHIJJJIJJJJJJJJJJJJJHJIIIJJHIIJJJHIGHHHHHHFFFFFEEEDEEDDBDDDD?CDDEEDDDDD@DDDDDDDDDD
@42T
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@@+ABADDHHFHFGGH?FFGFCCHIIIGGGIIGGIECHGGHIGFGGHIIGCEHGECFGGHI@GGHICDGGGIHFHFACCDBAC>@C>CCDA??BCCCCCCC
@42U
GACCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTAC
+
@@<DDDDDHADFFH>GGGBEHI:?DGHGIIG7FC7FHGI@@<BF:@@B@EC@ACHH?7@BBABBBC@@>>>>?@C<CCA>>@?BC9CA>CCBBBBCC?>A>
@42V
CTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACC
+
CC@FFFFDHHHHGJJJJJIIJIJIJJJDEHIJJIIIJJIDHIIIJIIJFJHH@FDI@FBHAAEEDCECEFDAD?=A=<ACABDAAA@CCDADDDDCCDDDD
@42W
CACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACA
+
?@;DBD?DDFFFFHIBEHGHBFEGIHHIIIEECHDHHFHIEFGEEGIGIEDEHHHHIFGGHHGGGGGGIIIEHACACCADEE@;@>CCCCCCCECCDCCB
@42X
CTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATCAT
+
BC@FFFFFHHHHHIIIIGIJIJIGJJJGJJJJJJJJJJJJIJJJIJJIIGJJFHEIHIJJFHIJIHIIIFFEHHFFFDDDEFCEEEDDDDDDDDDDDDDDE
@42Y
CTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGT
+
@@@DDDDDHHHDHGGB=FHHGIHGE8?FBHBGGFIIBHGIIGIC@GHGIIIGG@@;AAHH?@BACCE@A5(-;>@B?B?>?>5>C>>83@::AA@CCDBB
@42Z
GCCATATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATC
+
=@<ADDDDFAF:A:CDF<CEB,<?FEE9CE>HEG1?:CGFIIIBE4<B9?@G>3DG@8?>F@*?C<FD;=)84@@D:.=@DCEEEF@B;@;?>AAC9;@AB
@430
CTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCAT
+
@@?BDDADFHHHFG?FFHGGCHCGHH>EH@DHGGGGGBAFADB;DHF>F@FGGGCFHFC.7;@@77?;ACEE>BC@DC@A;@@>AC>@C@BCBB?>9AC::
@431
CTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTCAATTGTTCAGAA
+
@@;DDB=BD<:C<CC<?+333C<FHIIID<B3<2A91:4?EGD4?F>?*:9B4**0?B4B@F3/*9?.)/8)/8@F./).7CE@E@;=)?7)=.7;B3)
@432
TAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTC
+
@@@DDDDDHHHHGIHIGHGGHIIJJJJJIIJJJJJIJC???BGIGHIIIDGEHGHHIHFFHEHFFCCDEBEECCDDEEDEDDEEDCCEDDDCCBBDBDDCD
@433
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCA
+
CC@FFFFDHHHGHJJIIGIJIHGGIIIGJIEIGGIEFFIGHEGGGHGFHIJJJIEGIGIJJAGHHEHEHFHFEFD@DFEDEDBDDDDDDDDEDDDDDDDD
@434
GGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGAC
+
BBBDDFFFHHHHHJJJJJHDFDDDDDDD@BDDDD6@DDEEDEDDDDD:BDDDD<DD<CDDDCDEED>CCEDDDDD@DDDDDDDDDDDDDBDDBDDCDDD
@435
CTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGT
+
;?<D=??A<?FA>DF@@FBDF38B@;A664ADDBC>;;>;;8<=5)79B?<5(933>A>:33>>A>BA?B?52<@B>@::>>985+98<A>9A@ABB+32)
@436
CACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCAC
+
CCCFFFFFHGHHHJJJJJJJJJJJJIGJIJJJJIJJJJJIJJJJJJJJJJIJJJJJJJJJIJJJIJJIGGIJJIIIJJIIGGHFHFFFFFFEDEEECDDDD
@437
GTGGCTGCTGCCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGCGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGG
+
?8?BBDDD3C+A?3<+C:CEC93CE9DGE>CEFAFBCF:B98)*(7<F@)8)))=FE:;3=?3=?3@;;?>@?==>7;(,3'',558(>>@::>>(>+:?(
@438
CTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTACAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAAT
+
CCCFFFFFHHHHHJJJJIJJIIJGIJJJJJJIJJJJJJJIIAGIIIIIIIIJJIIGIIGIJJIJGF@GHIIGIJJJIGHFECHHHHFFFFDEEEEDCDDED
@439
GTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTG
+
@@@FFFFFGHGDFHEHGHIJJGHIIIIDHIIJJJJIIIEIGGHJ??DGIEHHIIGEGHIEIICFFCGIIIIJHFCECCDFFFFCECCCDEEDDDDDDDDDB
@43A
CCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGGTACACCCTCCGGG
+
CC@FFFFFDHFHHIJJJIJIEGFHHIJIJJGGEHGIGIJGHIIIJGIJIBGGHIJIHIIGHIIJJJIJJHGHHFFFFEEEECCCDDD0&)+(+3&2((&)9
@43B
GGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTTTTGTTGAGGCCAGAATTCATGTTATTGCCCCAAGCTCCTCTTCTG
+
@@@FFFFDHHHHHJGIGGIGJJJJCGGGGIHHJIJGHIJIIIJGGGGIGIJJGHHHFHFFFFECCDDDBDDDDDDECEDEEDDDDDDDDDDDDDDDDDDDD
@43C
TGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
BBCFDFFFHHHHHJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJ@FIHIJHHHHHHHFFFFFFDEEEDDDDDDDDDD@DD
@43D
GTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGC
+
@@@DFDFAHHFFHJGGHEHJIGIIJIGAHIGIEHGHEEID<DDFGGHGFIIHGBDDHHGIHCHGGICEHHDHFFFFFECCCCEBACACCCD>A@BACCD@B
@43E
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCT
+
??@=BDADDHFFHEHGIGEHEIFCCHE<?FH:CDH>F?;BFC?BFHEGGC@FGEGCAAGEHFHGBD1?@@CCEEB(>@ACCDD@B@CCCCCCEDACDDCDD
@43F
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
@CCFFFFFHHHGFJJJGIJIGHHFHHIIIJJJJJJJJJJJ?DGIHIJJ6BFHGJJJIGI;AEHHHFEFFFFDCDDDDDDDD;@BDDDDDDDDCCDDDDDDD
@43G
CCGGCTGTGTGTGTATAGAGGTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCAC
+
@C@F?DDDFCF?CACFHGHGDDFCCHIFIEGG@A?@?D@E9*?DEGHGGIG;F7ADEF?D@CEECCEC@CCD@@CAAA><A5@CCC9<<AACCAC:>>:?
@43H
CAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACT
+
CC@FFDDEHHHHHJEHIGHIJJJJHIIIJJGIJIICEHGJJJIHIIDGIJIJJIJIIIHHHGGGIHIGGHIJJHBHHAEH@DFFEFFCEEECCEDDDDDDD
@43I
TGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCT
+
CCCFDDFFFDHGHHIGHGIHHIIJHIEGEBBEFEGIDFFADBG=FEHHGIJEEHIHIIIGIEG@CCEEEAEHCHD?CDFED<;9@AB@;;@DCCAC?DBBD
@43J
CTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCC
+
??<+AD?BDB<D?42AEEC:33<3CCFEE4A+1:?9E*??DBD?DE>D?DD=EAD;89/8'(-@CC;@=7.)?=A?7?D>AD;8??A>>3(:>(,,5::::
@43K
GTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCC
+
BB@FFFFFHGHHHJJJJJJJJJJJJJJHHIIGIGIJHGHHIJIJJIJJJIIJJIIIJJJIJJJHFHHFFFFEEEEEEDDDDDDDCDDEDDDDDDDDDDDDD
@43L
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@@?DDFFFFHHHHIIJJGFEHGDFHGIIJDGHGIG<FHIIGIIIGEGGIIEHIEHGHHHFFFFFCEEEEDDDDDCDCA@C@ADDDDDDCCCDD?>BBDDDD
@43M
GCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGT
+
@@@FFFFDFHFDHGCFGB@>DDHGHG?FHGEIIII?FG?FG?BBBF>BCH@===CFHDH@EGCEHCEEHFEFFBC@>CECCCCCB7@B29CBBDBA@?C7+
@43N
CTAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGG
+
@C@DFFFDFDFFHIIGHICHIGIIIGIHIIGHGIIIGGIII@G9DBBFHEHIIBBHHIBEGIGHIF@DDGEHHEHHFFFFFCCBA?CDC>AA9?ACCCCC<
@43O
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCT
+
CCCFFFFDHFHHFGIJJIJJIJIIIHHIJIJJ?GHIFHFHHDHFHJJFGIIIHHHHHFFFFEEDCEEDDDCDDDDDDDDDDDDEDDDDDDDDDCDDEDDDD
@43P
CAGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGG
+
???DD100@DB:C?3+2<<<<C;F;??E<<D?DD30???BDCD@DBD@=4B=;====;@66?CCC;@>ADEBAAAAA:5>AAAA55>AAA::52><<<>5&
@43Q
CACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCG
+
8??DDDDAFFDDHEDGBFHEIHHBDAEF<@?@FHF>D?@??9DG>:?D9BD@EHCHIGGIIGABBF<=CGEECGFE>CC>E@;3=.;;776;CA.66;?
@43R
TGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CCCFFFFFHHHHHJJGBFHIHHHJJJJDHIJJJIJJJJJJJJJJJJIJJJIIGHHHHHFFFFFFDEEEEDDDDDDCCDDDEDCDCCDCDDDDDDDDDDD
@43S
ATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATT
+
C@CFFFFFHHHHHJJJJJJJJJIIJJJJJJJGJJIHIHIIIJJJJJJJJJJIJJJJJIGIIJIJGIIJJJJJJIJJJJJIJHFHHEHFFFFFDEEEEEEEE
@43T
GCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIIIJJJJJJJJIJJIGJJIIGIJJJIIJHIJJJJJJJJJHHHHHHFFFFDEEDECCDD;;;@CCDDDDDDDDD
@43U
GCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCG
+
@@@DBDBDA?DFFIFHHIIGHHHIFG@HGEHHHEHDHDGADHHGIJJJIJI>=FHIFF>AE@GEGI@A?E>?CDEEDBAACEDCCDECC3;@ABBBD<8?@
@43V
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
B@@FDDFFHFHHHEHHHGGGGJJJJJIJJJIJJGGECHDGIJJHIIIIJJJHIIJIIH>EFHHFDDCDDDCEEEEDD@BBDBDDDCCD>@@CCBCDDCCC
@43W
ATGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGG
+
CCCFFFFFHHHHHGHHGIIJGJJJJIIJHJHIJJIIFGIJIJJJJGIIIGHGHHFFFFDDCDDBDDDCDDDEACCCDDDDDDDDDDDDDDDDDDDDDDDDD
@43X
GTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTC
+
CCCFFFFFHGHHHJJJJJJIJJJIIIIJJJJJIIJJIJJJIIJJJJJJJJJJJJJDEIJGEFHHFFFFFEEDD@BDDEFDDDCCBDDDDDDDDDCDDEDED
@43Y
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGTGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
?;?D+2AD?DBDDE9A?A:CFII93@FAF;:C:DDB)?))9?DD9?DBDB?B).=CAD=7=).==A=7).).)7?;;;?36@3;A3(,,,,'5>:35(::>
@43Z
GGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGG
+
CCCFFFFDHHFHHJJJJIJIJIJIIIJJJJJJIJGIIIJJGII?FHIIJ'<FHGHHIGIIGHIG>CH/?DFFFEFDDCCDDD>CDDDDDDDDDDDDBDDDB
@440
CCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTC
+
@@@DF?D?DDHC@EGGIG>HGHC?CBHCAHHGEG<C*9?FGGHF:?9DBBFHE>CCGIGB@G>B=FHF@7CHDGIIGGG>CH<EBEB@CECECEEA5@>@>
@441
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@C@FFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJHFHHFFFDDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@442
AGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJIJJJJIJJIJJBFHIIJJJJJIJGHHHHHFFFFFFEEEEEEEDDDDDDDDDBDDB
@443
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCT
+
CCCFFFFFHHHHHIEHGGJJJJJJIJJJJJJJIJIJJJJJJJJJJJJJJJIJJJJIIJJIIIH:BCADDCDCCBDDDDDDDDDDDDDDDDDDDDDDBCDDD
@444
GGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
@@@DADDDDF8F31?GEB?;AD@CG?):C@D??D9BDFIIB?BB7=BDA@F@FCG;CD67@;=>E>);?D;=;@CC==??@BB?@<@@3:::(8@9>BB
@445
TTCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTT
+
??8A?DDDFDHHBFB?EAGEFI@HE?:A@HBBHIIGGI@GHCHBDCHF@FCAGCD?D>@<BF<FGIIIIEHHIGGDGCGCGGHEEHEHA=A;=?CCDECDE
@446
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
CCCFFFFFHHHHHJJJIJJJJJJGHIJJJJIJJJJJJJJJHIJJHGIJJIJIJJIJJJIJIJIGIHHHFHFFFFFEDDCEDDDDDDDDDDDDDCDDDDDDD
@447
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGAAGTATAACCAGTGGG
+
@@;DDF?DF?FDHIEGGHDH@FHHCHIIIICHHCHGHBFAFHIIIIIGE@FGHGIIHGEGG@EAHEEGFHHF>0&))+(4:(3((3(++4(:(+2(4>(
@448
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCT
+
@@@DDD?DFHHGFIIEHHGGGHIDBBHHGECDIIIIIGGIIJJIJGIJDBIHGHIIIJJIIFFBHGHBEHHHHFFDDCCDCDCDDEDCCC?BACDDDCCCD
@449
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTT
+
@@@DBDEFFFHHHIJJJJIJJIHIIIGGIEIIIIJJJIGIIJJIJJIIIBBFEGHIGIGI@GGHGEHFEEDDCFCEACEE=?>@CDDDCCCCDDE>ACCCD
@44A
CCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTT
+
@@@DDFDDCFHAHGGHGIHGFHIJGAFHHGIHHIIIHIGJIIJJHIGGJHGGIJGIJJJJHIEGFHGIIJGFHGGFHGIGEGJHFHHHG?CDFFDAECEE
@44B
AAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCC
+
CCCFFFFFHHHHHJJJGIIJJIJJJIIIJFHIJIIHJJJJEHGIGJIJIIHIHIIHGGHIIJFHIHGHIJGIICHIJGGFHGHHHFFFFFEFEEEEDEDDD
@44C
CTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCT
+
CCCFFFFFHHHHHIIJJJGIJICHJIIJIIGIJJJJJIIGIIIICGIFIIFFGIIIJIIIIJJIIEH@GIIHGCDFDCFFFEEDEEEDDDCDDDCCDDBDD
@44D
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
@@@DB6DAFF<ADAE@BGGGIIAGF<?CBBFHG:D@B3?FH@DHGHIDGFHIEG@GE@EECEEEED43?A@ACBCC=@CAA;CBBB85?ACAC:B@AC>4A
@44E
GTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAAT
+
@BCFFFFFHHGHHJIJJIJJJIJJIIIJJJJJJJJJJJJIJJJJJJJJHHJJJJJIJIJJJJIJHGHDEFEDEEEEACDDFDDDEEEDDDDDEEDDDDEE
@44F
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@B@FFFFFHHHHHIJJJJBFHJHIJJJIJGIJJIJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDD
@44G
GTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGG
+
??;BB=ABDDFDHHGGIIGGGEAEFGGCFFFDDC=?BDFDBDEGHIGAC8=@4@EC8EFCEFFF;>CCCBBB@CCCCC>@@@C@?@C@BB<98<@528<<
@44H
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGT
+
@@@DDBDADDFADFFH<CACHDBFDHFHII:CGDDHIB?F4:?FHGGIF@??FBD:6CA8=E@==@GACHAED@CE@;>=.6;6(,58>>C?CB@+2:4AC
@44I
CCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGG
+
CCCFFFDDHHHGGJJJJFGFGIJJJIGGIIIGHJIIGIIJGHIFBGIIGIIJJJ;EEBDFDDECACCDDDDCDDDDDACDACDDDCDCBDDDCCCDCCCDD
@44J
TTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTC
+
?@@?DDD?BFHHDBAFFE<AFFBFEHC>EGHI@EECCHGICHCGBGHIICGGIGI07?B<DFB<<FFEGHEG=EHHIGHCAEHFHEDDCDD;@CCCCA@
@44K
TTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGAGAGGAGGCTCTC
+
=;==ADD8<A;F;F@13C;33AA<A8:)?GGE4CBF=)?F4*00?*?D<C=FC;C))=>).=AEE==3;;3)).6@..;(=55;5A;(((,5<(()28234
@44L
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTG
+
@@@ADFFDFDHGD+<CCEG>E>AHIEIGCHDGGIG?C?:DHGGBGGGEHICAFHI@FHIGGIDIID>FGGGII.:??@;@AACEEC<CDDCCACACB?B?@
@44M
CCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTG
+
CCCFFFFABABBFAAC?@GHGIIHGGFHFGFHIHGHCGGGDGDHIGFHIIGIHGFGGGDFIIDEGEEEEF>?@DFECC????CACACCBCCCB??BAA@CC
@44N
GTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCTAGAGGAAAACAAGGAGGAAAAATAGTGTAAAGTTAGCAGAAACAAGG
+
CC@DFDFDHHFFFHIGIICHIEEHIJDIIBHGGH@FHI@FDDCH>FFIIEBFHGEHHJIGHDHEHIHFH7@DE@AC>;@>@ADCEDDDDCDDDDDCDDD
@44O
CAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTG
+
CCCFFFFFHHHHHJJJJJJJIJIJJJJJJFGEHIJJJJJJJJJJJJJFEHJJJJIIJJIJJJJ)BGIIJJJJJJJHHHHFFFFDDDCEDDDCDDDDDDDED
@44P
GTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTT
+
@@;DDEFFGDFDFHIIFGIIIIECHIIEHGEHIIIIIGIIIIIGGGIGGIGGHIIGHIHIIIFGHGIIIIIGIIGIIGAEHEHEEABBDE@CEECEFDCCC
@44Q
GCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATC
+
CCCFFDEFFDHHDFHGDGHGIIIIJJJHIGDHIGFGGHGGIJDGFHIGGGGEHGIJGIGEHEGCGHCGHEIIIIJIIIIJFEEEHFEEFFCCCC>AC?ACD
@44R
CTTCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCT
+
?@84ADD=BFHFFGHIIGIIBHFGGHIGIIBD=BFHIIGGGDGGG>AFACHHGE89A?';?BBDDDB7>@AC>CC49AC>ACDDDD@BD<B9>@<BBDB@>
@44S
CGCGTGCAGACGACGGGGTTGGAAGCCTGCGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGT
+
?@<D:8@DDDHAFEGBG:DGHDE9FGEHIGGIB<E@EEHHHEB>CBBB5<BBCCBB@BBB<BBBBBBBB-9B:BDEA@4:>><B>@@CCCCBBBBB<ACC4
@44T
GTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGC
+
@CCFDDDDDHHHHIJJGHIJIJJJIJJJJJJJJIIJJJIJJJIFHIIJJJJGIIJ;FGGHCCGGIJJIJGJJHHHHHHHFFFEFFFEEEEEDDDDDDDDDD
@44U
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
?@+AA=@DDAAHHI@GIBGADEHBFGDFII?DHGEDGHE2B68BFGH<CBBDAFCHG@AHGEEA?CB;;B@CC>=5?@A>CCCC>>>;@593@43::?CC>
@44V
TGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGG
+
@C@FFFFFHFDDFGFGHEEGCHHJIJJJIFGGIGDGEGHHJJIJGGEHIHFHHJGIGHIIIHIGIIIJIGIEGAHFHHHGFBEBCFCEEECEEDDCDADCD
@44W
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCC
+
@@@DDFADCFHHFHIIIEBDHGACFEHIIBH?DG@FHIIIIIIDCE8DGIGGGEGHGEGC@GHIEHECCHADEFFABDEDDDCCC@CCCC<A:>CDCC@C
@44X
CAATGATATGTGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGCATAATTCCTTT
+
@@@DD?DDHFHF<=EEGG;E>9AABHIGCHBGFHEGEC?HI*?AA<<DEEHGDFHCDGEHIIIIGEAAFFGGGI:CHGE??;?;@BEEEBD@CC>;ACCCC
@44Y
GGTCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGC
+
CCCFFFFFHHHHGIJJJJJJJJJJJJJJHJJJJJJJJJJJIJJJJJIIIJJIJJJJJJJJHHHHFFFFEEEDEEDDD@BD@CDDDDDDDDDDDDDDDDDDD
@44Z
CTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTCTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTG
+
?@:BDEFFHGHHGGIIEHIJJIGIIJIJJJJJJJJJJJIGIHGIIIJJJJJJJJIJJIGIJJJIIJIIIJHHGF8?ACDDDDDDDDDDDDDDDDCDDDD:A
@450
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGG
+
CCCFFFFFHHHHGJJIJJJJJJJJGIJIJJJJJJJGHIJIJGGIIJCHHHIJJJJFHIGIJIIJJJHHHFFFFFFEEEEEEDDDDDDDDDDCDCCDDDDDD
@451
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTG
+
+8:=+A=+AD8<:C3:C:<:3<FBC;F?AFC4CDC<CDDDBD4B><DD?D3BCEEC>BDC<3==CD)-'-=:=)).77?;77>@AAA;;;;>?8??989&0
@452
GGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTC
+
?@:BDFFEHHHHHHIJJJJJIJJJIJJJJJJJJJIJJJJJJJIJJJJJJJJIJJJJJJJIIJHHIJJJJHHHFFFCCEEEEDDEDDDD>BCDDDDDDDED
@453
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
BC+BDFFFHHHHHJJJIJJJJJJJJFHIGIJJJJJJJJJJJIJJJJJJJJJJJJJHHFFFFFDEEDEEDDDDDDDDDEEFEDDDDDDDDDDDDDDDDBDDD
@454
CTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGAC
+
@@:ADDDEDFFHFIGIEGHIGGHHIEHFE@FDHEHDGIHEEHIJJGIEAHEG@?DHGHIIIJJJIJJIIJJDHHFHHHHHFFFFFFFCEEECCEDDDD?@D
@455
CTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCAC
+
CCCFFFFFHHHHGJJEGHJJJJJJJJIJJIJIGHGHHIJIJJJJIJJJIHHIIJIGIJJJJJHIIJJHHGH?CEEEDFFFFEEEEEDDDDDDDDDDDDD
@456
CTGCTCATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTT
+
CCCFFFFFGHHHHJIJJJJJJIJJJJJJJJJJJJJGIJJJJJJJJJJHIJJJJJJJJJJJJJJJJJIJIIJJJJJJJIJJJJJJJJHGHHHHHFFFFFFFF
@457
CTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCC
+
@<BFFDFFFHHDHIIIJIFHHIEHICHHIIHIGGEGGCFFGFHCHGEHFGCGDGEFFCDEHHIDHEEHFEAB@@BEBCECEDDDDCDCDDCDDCCDDCCC?
@458
ATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACAT
+
CC@FFFFFFHGHHJJJJJIJJJIIJJIHIJJJJJJJIIJJIIJJJJJJJJIJJJJJJJJIIIJJJIIGJJCGIGGHGHEFDDFEEEEEEEDDDDDDEEDDD
@459
CTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGT
+
:??DBDDDBD4D?A:8@1AFFEFIFIIFCE>FAFIEIICDGEFFAFFIEB>E=6=D@@ECA?E?EEBDD>>;>@?>>8=ABB>>5>:@:A@<?<BBBB9?2
@45A
ATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATC
+
??+==DDBDD:C?E9@?D;;:CE4CEECC<CE@11C3*C?@44BD>DEI>DBD9BDDE@DC<CD>DDEEE@@A77@;AAAAD>A@;A;:@;;6>A(;AA
@45B
ATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCC
+
CC@FFFFFHHHGHIIGGIJGGEFGHGIJJIJJJJJJJJJJJJIIHIJJJIIIJJIJIJJIJJJJJIJIJHFFDDD?CDD@CCDBCDDDDD
@45C
CTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCC
+
@@;DDD?DDFFHHIIIIFIIIIIGIIFEHIIIIIIGIG@CCGIGIGIIEGIIIIIHGIIIIIFIIIIFFEFEEDEEEEC=CCCACB?AABBBBBBCCCCCC
@45D
CTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAAT
+
BB?DFFFFHHHHHJJJJJJJJJJJJJJJJHIJJIJJGIJJIJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJIJHIJJJJIIJJJJJHHHHHHHFFFFFFDE
@45E
TTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAA
+
??:BBBBDDB:FFHII8@G?CHHGBEG6)?:??BGEFBAFCGIIFEHGGGHIGIFEH>A@;;>>A@688<8988?@::AC>CC?8505<@@AACCB<(5
@45F
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
B@=DDEFFHHHHHJJJJJHIJJJJJIIIHJJHIIJJJJIJJJJJJIJJJJJJJJIJJJJJJJJJJIHHFFFECEEDAEDDDCDDDDDDDDDDDDDDDDDD
@45G
GCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGG
+
CC@FFFFFHHHHHJJJJJJJJJJIJJJJJIJJJJJJJIJJGGHIJJJIJJJIJJJIJJJJJJJJHHHGHHFFFFEDEDEEDFEDDDDDDDDDDD?CCDEED
@45H
GGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGG
+
@@@DDDD;DFFBF@?;E8:3AFH<<DE92:CG;F;9??C??DD9B999B06?DA:8BCFGF@=@=@C477@=;CE?ACECDD>BB>@BAC;;3;35>@
@45I
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAAC
+
@@+ADFBDHHHGHIIIIIIGIIHIIIGIIIIIIHIGIIIIIIIIIIIIIIIIIGHHFFDDCEECCCDD;ACBBDDDDDDDDDDDDDDDDDDDCDDDDDDDD
@45J
TACACAGTTGCTTTCTTTCCCTCCAACATAAGACTGACGCATTAAGGACACCATGGCCTTACCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCT
+
?@+4=BDDHHAHHIGIIIIIIIIIIIIGIGIIGGIIIGIIBHIIIGHIIGHIIIIIIIIIIIIIIIIGHH7AHFF7?CBACCCCCBCBBCCCCCCCCCCCC
@45K
CTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCAT
+
CC@FFFFFHFGHDHGGIIHIJHJIJJJJJJJGIIIIIJIIJIJIFHIJJJJJJIJJJJJJJIJJIHJJHJJJJHHHHEEHFFEDDFEDEEEEDDDDDDDED
@45L
CTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCC
+
@CCFFFFFHHGHHIJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJIJJIIIJJJIJJJJJJJJJJJJJJIIJJJJJJJHCHHHHFFFFFFEEEEEEDDDD
@45M
AGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTATGCATATCTCCTGATGCAGTCTGCTGCCCGTAGC
+
@CCFFFFFHHHFGJJJJJJJJIJJFHIGIIDHEHG:FCCDDHGIG9DFHIHHIGHGIJJJHIEGIJJJFHHGGHGHHFFFFFCEACEECDD@CCBDDDDBD
@45N
GCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGC
+
?@@DFFA?FFFDBEFFCGGCDFEGHIGHEHIEIIIGIFHIGGIIHIGHIIIIIIGIIIIIIIIIIGAGIIGGGIHIIIEHG?ECEDFFCDFCCEEDDDAAC
@45O
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCCFFFFFHHHHHJHIJGHIFHIJJJJJJJJJJJJJJJJJJIJJJJJJIIJIJJJJJJJJJIJIJJJJHHHFDDDDDDDDDCD>ACCDDEEDDDDCCDD
@45P
ATATGCCTGGGTGGTCTGTGCATATCCTTGAGCGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGG
+
;?@BD4A?D=C+<C)<C:CFHFC?FE9@@G@A*0)?:@<@F=8?389>>BA@?AA3,>>@A?9<@B45;;@5AA>>BB<3@B4:A@>>>>@BDDD:A@?85
@45Q
GCGGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTC
+
@@8DDFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJHIJJJJJJJJGIJCHFHHFFFFFFEEEEDDDDDDDDDACDACCDDDDDDDDC
@45R
CCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGTCAGAGCTGAAGTGATCCTCGCCGTCGGTATGTGGG
+
CCCFFFFFHHHHHGIIJJJJJJIJJIJJIJJJJJJJJJJDGHIJJJIJJJHIJJIJJJJJJJJJJHHHHGGFFFFFF@CEFEEEDDDDDDDDDDDDDEEDD
@45S
ATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAG
+
18?4=D>>CBDBD:2<<AC<+A<CE>E)?C:?DDID*:B?BD<<DD@/.78=CC74@@C==A>44?DADCDD?BA7;;.65;@>>;>AA-3555;>A??
@45T
CCATATATTCACGAACCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTCGTT
+
B@+BDFFFHHHHHJJJJJJJJJJJGIIJIIJIIJJJJJIJIJJIJJJJJJJJIJJJJIIIJJJIGIJJJJHIJIJJJJHHHHHHHEFFFFFFEFEEE>BCD
@45U
GGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTT
+
CCCFFFFFDHHFFGGIGIGFIJG?FGIGIIGGIIJJJJGGHJJIJJJIJIIJHHIIIJIJIJIGIJJJJJIIGGHHHHHGFFE@BD@CDDCDDEEDCDEED
@45V
TTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGG
+
@B;BDFFFHHHHHJIJJJJIHIIIJCGGIGIEIIJGIIIJIJGJIIIJJJDHGHJGHHEDDBCDDDDCDDDEDDDDDDDDDDDEDEDDDDBDDDDD<BBD
@45W
TGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCA
+
CCCFDBBEHGHHHIIJJIJJJGIIJJJIIJJIJIIJJIGIIIIIJGIJIIJIIJJIJIIJJJEHEEHHBEFFDEECEEEDDCCDCDCDDCCD@CACDCD
@45X
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGG
+
@C@FDDFBFHFFFGGIEHHHIJIIJJGEIDCFHHHGIGIIGDFEHGIGGIHIIHJJIJJBGGHHGEGCGGD7=A?@CD?CCDAC;@@>@CAC;;@????=<
@45Y
CTTCATATTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGT
+
+:?=ADDDFDFFDFDEGBD4<<FBFE?<FHI>HBCHH@ECFDG???CF?BFB4D?<F@G<?4?<DG@<8/8F8@@=F@7)=C;?7=7A777?D77;BD;;6
@45Z
CCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATC
+
CCCFFFFFHHHHHEGIJCFGIIGHGGGHGIJJJJIIJIIGGJJJGIIJJH?FGHIBFGHIGHIIGGGJJGGGIFJJIIHFEEEEEFFFFFDCEBCECDDCC
@460
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGG
+
?==?DDBDHDHAHIAEFHHIG@FIDGGIIHIG9DHGF@DGEIAHIICGC<DGDFCHIEGC@CGID;E>CE27?>7)6;;@;A@@?BB,8>99>CCCCC4:?
@461
CTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCT
+
CC@FFFFFHHHHHJJJJJJIIJJJJJJJJIJJJJJJJJJJJJJHJJJIJIIIJJJJJJJJJJJJJJJJJIJJJJJJIJHHHHHHFFFFFEEEEEEDDDDDD
@462
GCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCG
+
;@?BDDDDHHFFFEIBEHHHGHG@HEBFDEFHIIGIIIGGIIIEIFCHEH?FFFHHGHCFGEHHGGGE>ACCACBEDBCCCCCCCCECCC>:A?8<?@A?@
@463
GGAGGGGCAGTGACTGGCTGCATGGGGGAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGT
+
??;DD)080<2222<2+C???9E9?D;)60.B8868=;./8@=7@?:C<@;7A>.66.6@;5;A5555;;>5>>>:559>5&(8+5;?A?5AA>><09>8:
@464
GCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCT
+
@CCFDFFFGHHHHJJJDDDDDDDDDDDCDDEEEEDDDDACDDDDDDDDBCDDEDDDDDDDCCDDECDDDDDBBBDCDDACDDDCACDDD@CD:ACDDDDDC
@465
CTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCT
+
@CCFFFDFHHHHFGHEGGHGAHIGIIIIICEEHHEG;?FB@DDGIE<BDEAFF>DGGGG@AHH>6=;EEFD@CDEEC@;>CCDCCCC5@CDA>CDCCCCDA
@466
CTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACT
+
@@?DDFFFGHFFHIGIIIAHEGDEIEHHHGHGHCGHIHDFGHG??DGGHGHGGIG?FDFGHIIICCHEEGIIGGIHHFFHHFFFFFECCCEECCCCCCDCC
@467
GGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCTATTGTGTTTATATGCAC
+
?@?=ADDDFHHAFBHIBFCGGHHGHIIEBGBE@CGCCFEHBHIIHGDDFA8BFGEHGIIIGIEEED@EEHEHHH>C;@D;CCCDDDC;@=CCACEEDA@C
@468
CCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGG
+
<@@FDDFFFHHHGIJJIIIJIJJGIJJIGIIFIIJGH@GAGIJIGHHHHGHFEDFD3;@CDDDDDDCDDDD:CDDDDDD<@D8?B5@CBC@?BDD4<?5??
@469
AGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGTC
+
@C@FFFFFHHHHHJHGJJGIJJIHIIJJJJJIJJJJJJHIJJJIGIHIHFGHGFFFFDE;CBDDDDDCEDDEDDDDDDDDDDDDDDDDDDCCCDDDDB@CA
@46A
AATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGG
+
BB@FFFFFHHHHHJJJJJJJIIFHJJIJJIJJJIJJGGBGIJIGIJJJJJJJJJIIGJJJJJGJJJJJIJIJJJHHHHHHFFFFFFACDDDDDCDDDDD
@46B
CGTGACAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
@@@DFDFFHHHHHJFGIIIIJJJGGHFGHGFHIJJJJJJJJJJJGJIJIIIJJIIIIIJAEHHDEFFFDDEACCAAC@CC@ACCCDCDDDBDCDDDDADC
@46C
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACT
+
CCCFFFFFHHHHHIIJIJJJJJJJJCHHIGHJJDHIJIJJJIJJFHIJJIJJJJJJJJJHHHHHFFBCDEEEDDDDDCDDDDDDDDDDDDDDDDEDEEEDD
@46D
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
@BCDFFFFHHHHHJJJIJJHIJJJJJJJJJJJIGIJJJJJIIJJIJIJJJGJJIJJJJJJJJJJJHHHHFFFFFED@CEDDECDCCCBDD>CCCDDDDDDD
@46E
GCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGT
+
@@@DBDDFHDHHGIGHEHIJJHCHHGAEHCGGGIJGHDHGGGHIHIJIIDGDGHDHGDDIGIHGGHGIIIIJIGIGGGIGHGHHCDFFFFDDBDC;;>C@9
@46F
CACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGA
+
@@CFFDFFDFFHHIIIEHIGCHGEFHIIIIIJIIGHGGHEEGB@GIIIIGIIIGIFHGHGCGHHGIEGCHHGHCHHFEFHHFFEDFFDEEEDBDDDDD
@46G
CAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGG
+
@<@FFDFFHGDFFHIIJIIJJHIIIIIGEIHG;=CCCHFHHG?DFCACEDEEDDDD@CACCCDCDCBDADB9ABBD@B+2:AACDDBBD@B?ADDD99@CD
@46H
CCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTG
+
CCCFFFFFHHHHHJEGGIIIJIJJJJJIJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJJJJHHHHFFFCCBDDEDDDDDDBDBDDEDDDDDDDDDD5<
@46I
GGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTC
+
@@@DDFFFHHHHDGHIIIEHJIEIIGGIJIJIIGIIIEHIJIIEHIIJIJJJJJJIJJJJIGHGHG=FGHGHJJJIJEHIGIHGHCHHEEFFFFEEECEEC
@46J
CTCCTCTTCACGTAGGAATCCTCTTCATAAACATCTCGGGACAAGCCGAAATCCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCTGC
+
@@CFFDDBHFHHFHGIJJJIJIGIFHGIIIGIIJJ@GHFG>GHHGGIIDHEGHJJJIGHHHFFDEFFFEEBDDDD???ACDCCCCCDDDD>>CDDDCCCDD
@46K
GGGTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGG
+
@CCFFFFFFHFFHIIIIJIJIGEIG@FGIGIIGGIHHDCHIGIIIGIGIJGEFGHGGIJGGGGGBEFDDFDDC@@?A<C@DBB>?>CDA@CCDDDCCBD
@46L
CTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACT
+
@CCDDFFDHFFAFHGIGIIJIGIIJFFIIJIHIIJIHJJJIEFFDGCHGIJJBHIJIEHHGHGFFFDCCDDDDDDCDDDBBDDD4>8?BC@<CCDEECDCD
@46M
CTGGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTG
+
@@@DFFFFHFHHHGIJJGGGJIIIJJIIGHIIIJDFHJIBAHHHGFFFEEDDDDDDDDBDDDDDDEEDDDDDDDCCCD@CA@CCCCDCDDDDDDD@BDDDC
@46N
CAGACTTGGTGGCATTCTGCATGGGCCCCTGGGGCAGGGCTCCCATGGGCAGCGCCTGCATCAGCAGCGGGGTGGCCCTGCGCATCTTGCTCACAGGCTTG
+
?1;?DDDD?FD?8EEFBG4CDC,<?FEFEID?7DG0D6:D28;F>FCFC;@B<=ADD2>(6;3.5;,;;:@B&5><?(+8?3<-0<::4:44(::>BB??B
@46O
CTTCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAAC
+
=B1=BBDFHHHHHGGIJJHIJIJIJGIJJGBHIIJJJJIJJIHIIIJJJJJJJCHJJHIJIJGGIJJJ@CEEEFBDEFFEEEA@CECCCDDDDDEDEDDDD
@46P
CCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATAATCTATCGGCAAAGCGGTGTTGATT
+
@@@D1D?2A:<CFEGI7F:?8?8DAF??DDD00808?99D<8(7.88@7C)..>E=7=C=777.?26@;>(.6,;A(->-(;5,',,&++()&&)0++(+:
@46Q
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTG
+
@@CDDDFDHHHHFFHGIHIHIIGGDGGIGIGGIDHEHGHIEGHJIIGIIGHGHHEHFHHFCFFFECEEEEDDDDDDDEDDDCDDCCBD?<@BDDDDDCCDD
@46R
TGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCC
+
==+=BDDDHDHABBFGGH>CHICFGIHE@D?FE??D9CGIH0B?F4BDDFAHFBCFHGHIIIIIHHGHCHGEGHHAEEFBCCEECDCCCCCAAAACD>>AC
@46S
ATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTA
+
=@1ADDFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJIIJJJJJJIJIHIIJDIIJJJJJJIJJJJJJJJJJJIHCHFFFFFFEEEEEEEDD
@46T
GCTTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGT
+
?@8+=DDDDBFDBEFF@C@?FDGFFA=@FF<CFFEBEFFCDB?CBB@A9;>ABA(5>A@@BAB@:4>>@>@@@AA?9@B@??>44::>@ABB?<BB@BBBB
@46U
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJJJJJJJJJJIIHIJJJJHJJJJJJJJFGIJIIJJBGHIIJJJJJJ@EHHHFFFFFFFDEDDDDDDDD=BDDDDDDDDDCDDDDDDDD
@46V
TAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCC
+
@C@FDBDDHGGHHIJJIHIGHIEGIIHICDGGHEGGBFIEBGIGGGFHIHGJ@@GHICCEHCHFGFF?DFCBAABCDDDDDDCCCCED;AA@CDDDDDCDD
@46W
GTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTG
+
@B@FFFFFHHHHHFHIJJJHHGHHIIIJJJJIIJBGHIJIIIIIJIJJJDHIIIJDIJJGIJIFFHGIJJJIJGHEEHFFFFFFEEEECEDDBD?@BBDDD
@46X
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGTTGAGTGCCATATGC
+
@@@DDDDDHDB:AC?F=FDFGIH<FCHGGIGI?8DF9D4@FIHC?FFEHG2;CFD7;3;CG@>CC?>.;;BBB@BCDA@C355,5<A>A:AC@:AC@>
@46Y
GTAGGATCCAGTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATATCTGCTCGGTTGCCCAT
+
???A=32BD:?2AA:EEE:C1:C???DC:BD?00(?D?1B=36=7)=7A@;CC;??=?D?;;7@..6>AAA;;>A>>,5:;B5((,;35,<5+0)(+4:3
@46Z
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJHHHBCD@DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@470
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGG
+
CC@FFFFFHHHHGJJJJJJJIJJJJJJJIJJJIJJJJJJJIGHIIJJIJJIJEIIJJIJJJIIIIJJHHHHFFFFDD6=B@BD=BCDDDCDDCDDACD@BD
@471
ACCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGT
+
CCCFFFFFGHGHHIJJJIIIJJIJIJIJJJJGHJJIHIJIJIIIJIIJIHHJJHGIIJHIEFGFIIEHGFBCHIHHEFFFBEFFFECCDDDCDDDD?B:
@472
CCTCCTTCCCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTTCCAGGGGCACAATGGGGACCAGTTGAGCAACTGGTGGTGGAGGCTGAGGCGGAAGGCC
+
?@:ADDFFHHGDDDHGIIGGDHG?GCCFGGI@>CFG;@FCHDGGGEC=6;8BHHCEE@>;;=AAA>>@3;@5<A?C::AB;<@(<<828?<@D>>BDDDBD
@473
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
1?14==ADH<DDFF>BFCEHDBFEAH>HB+22@E)CC00BGH*:;DHII38888)/=;F@48@D;CHA;?7;=5(.;((5-->;A<5,,:@:A<())<CC>
@474
AGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACGCTGCCACTGACG
+
CC<DFFFFHHHHHJJJJJJJJJJJJJJJJIIJJJIJIIJJJJJJJJJJJJJJJJJJJJJJJJJEHHHHHFFFDDDDDDDDDDDDDEEDDDDDDDDDDDDDD
@475
CTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTAC
+
:B+4BDEFHHGHHJJJJJJJJJJJJHJJHJIIJJJJJJJJJJJJJJJJJJJGIJJJJJJJJIJIJJJJJJJJIJJIJJFHHHHHHFFFFFFFEEEEEDDDD
@476
CTGTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGAT
+
@@+=B:BDFFFDDFEIFEHDFEFFFEGFECFFIIIIEFEIA?BFFIFD9B>FFFCCFIFIGFIFFFFIEEECEEFEFF@B);BDDCCB:A6@BBDBABAB
@477
CTGATACTCAGTTACACACTTCTCAACTTGGAAGCTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCC
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJIJJIJJJJJJIJJJJJJJIIJJJJJJJJJJJIJJJHHGGHFFFFFFEEDEEEDDDDDDDDDD
@478
CCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATA
+
CC@FFFFFGHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJJJJJJIJJJIJJJJJJJJGIHHHHHFFFFFFEEEEEED
@479
GCCGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTC
+
=@+=ADFFFHHHGJIJJIJIJJJIJJJJJJHIJJIIJGHHHHIIJJJJJJIJJJ@FGIHHIF5ADFDFFDEED;ACDDDDDDDDBDDDDDDDDDD@BDDDD
@47A
GTGCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTT
+
@@<DDFFFHHHHHIJJJIIJJHHJJIJJJIIGIJJJJJJJJJHIJJJIJJIJIJJJIJHIJJJJJHIJIJJJJJJJJJIIGHGGHHFFFFFFEEDEEEDD
@47B
GGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCC
+
BB1ADDDFGHHHGGIJGIJJIGIJIJIHIGEHIJJJJJJGGDHIHIJJHHEFHFFFFFDDDEDDCDDDDDDDACB=BDDDDDDDDDCDCCDDDDDDDDDCD
@47C
GCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCAT
+
@@;DDEDFHHFHHJJJIJIJIIJIIIGHJIGIGIJJIJIEIJGIJJJBGGIJJIEHGHBCFHIJIJGGIIIGGGJJIIJHGHCEHGEDFCDFECCEEDDC
@47D
GGTTAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGT
+
?@1ADFFFHHHHGJJJJJJJJJJJJJIJJJJJJJJJJJGIIIJJJJJJJIJJIJJJJJJJJJJJJJJIJJIJJHHHFHHFFFEECEEEDDDDDDDDDDDDD
@47E
CTGGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGG
+
:@14ADFFGHGHFGGIJJJIJJGJIIJJJJIJJIIJJDIIJI9BGGGIJJJJJJJJDIIIIJJJGIJHHHHFFFFF?A@@CECDDCCDCCDDDEDDDDDD
@47F
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
B@@BDDDFHHHHHJJJJJJJJJIJJJJGIJJJJJJJIJJIIIJGIJJJJIIJJJJIJJEHIHJHGDHHFFFFFEDBCEDDDDDDDCCDDDDD9@BD>DDDE
@47G
GTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTC
+
?B:BDFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJJJJJJJJJJJJJJIIJIIJIJIIJJJGIIIHHHHHHFFFFFFFDDDDDDD
@47H
GCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACT
+
CC@FFFFDHGHHHIIIIGIJJJJJJJEHIIIJIJJJIJIEIIIIJJGIJJFDHIGHIJGGGGIJCHGEEHHHFFDDEFECEEEEDDDDACC;>CCCCCCCA
@47I
TATATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTC
+
?B=ADEFFHHHHHJJHJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJHJJIIHHFHHHFFFFFFEEEEE
@47J
AGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
;@7BBDD?DCABD;A:121C8C?CD???DD=;F?B;BBBHGCHAHDHCGHECDH;=C>>BDBD@;AC>CC>CCCCC@:@CDC:A>AC@A2<BBBBCC3>
@47K
CCTCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCT
+
@@@BDD?B+=AF?GIEFGI<:3<<CF9EHDH4EEDCBBFE?C:FG>DBD<4*?F@BFC8B8?DFGBCFGIICCAFCAECECEFAFA7A;;>B>>>@6;?@9
@47L
GTGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTT
+
=?1=:D+AA4ACF?;C>FDGGEGHIH9+2A4CAB9?G9D<D:9?0:?ADDHGHGGHCBEHI:@;)7.=@=CEEH377;;@@>;6>;@C7;==;;A3;>@CC
@47M
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
@@@DDD?D?BAD?@EGAAF?EHIIIE<?GGIEG9??CDEGIIFIEE9FHA7CAA@=C>CHC;7;??;3;>@>CBB?=@>CDC@@:?>5>CCA>318?<8:>
@47N
GGCTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACT
+
CCCFFFFFBFHHHJJIJJIJIJJJGGIJJIJIJJIJJIJIJJJIJJJJIHIHIIHIIIJIJJIJIIIJIGJJJJJJIGIJJIJJIEEHHHHFFFFFFFDEE
@47O
CCTATATTGACTTGGAGCTTGGCTGTAGGATCCACTTTGGGGTGGGTAACTAGCGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCCTAGCTACTCTGCT
+
+1:4==B4?:+2,2AFFEFGF?+:1<ECB<B3C**:CC9*)?:??67=))))8);=A<'3?(5;:::(5@>AAB@:>AAA:>3(+44+(+3:+:A:@BBBA
@47P
CTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTG
+
CCCFFEFFHHHHHGDFFFHGIGGBHIGIIII@DCDDHGEGGHHEHC>FH.=CCAH7CGGGIIDHAAACE?BD7;BE?CE;@ACDCBBCD?B<?C>ACCAA
@47Q
CCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGCGAGGCTGCTGCCCATAGCTGCTTTG
+
B@?DDFFDFHHHHIJJJJJJJIJJJJIJIIHJIIIGGIIHIIHGIIIGJJGIIGIIHGJJJJ@BBEBDEDEECAEDDDDDDDDDDCDDDDDDDDDDDDDD@
@47R
GGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTT
+
??;B=D;=ADBCFBGF<AGE8@?1?D?FFBGIBB9?BF>9D8??B?@BBCBCC;@F=F=@@E9DF@CE;=BDBBD>@>@?7;;8?@AAB3::5<?@ABBB@
@47S
GCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGC
+
1::44A:B=A?FB?C@@?FGIF)2A?C?GF?G@;FG9?8(9*.8BB;7@@FFEI@D>6-(..733//8&08>AB>:9?@A@@B(2?::4:@A@82559>?B
@47T
CGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGT
+
CC@FFFFFGHHHHJJIIJJJJJJJJJIHIJJJJJJJJJJJJJIIHFDDDDDEDDDDDDDFDDDDBDDDDDDDDEDDED@CDDDDDDDDDDDDDCBDDBDD8
@47U
CAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATG
+
@C<DDFDDAFFFHE<CFHFHIIHGIEGI?CDHIIGIIIIIIIIIGIIGHIIIIIIHDACECCCCCCCCCCCCCECCEDCCCEECCCCCCCDDCCCCCCDD
@47V
CAGGCTTATTGAAGCCACCTCGCTCTCCAGCGCTGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTT
+
@@CFFEDFHHHHHJI;EGEHIHIHIIIIEIJHIJIIGGIIJGIIJGIIIGHHFHHFFFFD<@DDBDDBBCCDCD:>:@CAC@<C?58<<CDA@CDDD@DCD
@47W
GCTAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGG
+
@@8=AADDHHHFFGFIGGIIIGCHH@ABBEHDGGDEAB@FGHDGBF@CGG==DHG?)777;@BD@BAE>AC,;@A@C;@@<>>::,,5:?@?BBCC>B@>C
@47X
CCCGGGGACCCCAAGTTGAGCTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGA
+
1:+4=DD@C?AADG=CAF??DBF@B?GEBFEF8(7@FFEEIDFCCEDEBEB<99>@@@AB?BAAAAABA@@?B?<@@BBA@?AABBBBA??B8<A:AABB
@47Y
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CC@FFFFFHHHGGGJIIEHGHIJDIIIHIJJIIJIJJJJEIIJJFGCEIIGIDGHHIJIHFHIGIGHEFHFEFFFBEDECDFDDCDCDD=@BCDCDDDDCC
@47Z
GTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTT
+
B@@FFDFDBHHFHIGIIGHIIIIJIGIJIIIJGEIFGHEGHIIIGHIIGGGGHJJIJJIJIIHGHHFFFFFFCCCCCCDDDABDDCDDDDDCDDDECDD>A
@480
GGGTTCTGGAGCCACATTACCTGGGTTCTAGCCCAGGTTTGCTATTCACGAGCTGTTTGGCCTTGGCAAGTTACTTAACCTCTCTGTTGTTCATCTGTAA
+
B@@DDFFFHFFDFHIJJJJIIIJIICFFHIHIIJJJJGIIIJJJJJJIJIIGIHIIJJHIIJJIIHHHHHFFFFFFFEEEEDACCDDDDDDDDEEDDDDE
@481
CTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGGCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGA
+
@@@DD?DDFDDBHIIIHGCCFBFHHIG@BBEBFHAFHIIIIIII<BFGHGECHEGBAEFHFHEC>@;BCC;ACCCC>;@CC@>CCCCBB3?::ACC@@B
@482
CCCCGTCCCCTGTCACCAACAGTGAGCTGGGGAAAGCAGAGAGCATCAGAGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCN
+
CCCFFFFFHHHHHJJJJJJJJJFHIIIJJJJJJJJIJJJIGIJJIJIJJIJJJ@GGEHHHHHFFFFEDEDEEDDDDDDDDDDDDDBDDACD@BD8?BDBD#
@483
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTAT
+
BC@FDFFBDDDBBDDDDACCDDDDEDDDB>@CBB@BBDDDDDDEDDDDCDDCDDDDDDDDDB@<DCDDDDACDD>CCBDD:@C:A@CACCDDDDD9@C
@484
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
@@@DFFFFGGFHFGEGIGGHIIIIJGGFHHIGGEHJGBHEEGFHIGCHIJJIIIBHGEIIEFDEGIH;?C6;@DEFEECAEEDDDDD3;>>BCDCDCDCC#
@485
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGN
+
@@@FFDDDDFHFFIAEHGGIIIJJIICFGGGHJGIGIGIJIJJIJIGGGIFGIIIFGHH?BBEEECCDCCC@CCDCCACDDACCDDDDDDDD9@CDDCD@#
@486
GCATGATGCAGTGGGGACACTGGCGTGCTGGATGGGGATTTGGGCTGCGTGCAGACGACGGGGTTGGAAGCCTGCGTCAGGACCCTCGGGGCGTACTGGGN
+
CCCFFFFFHHGCFHHJIJIIJJJJJHIIHIJDFHJIJHIIJJIIJJJJIIIHHHGFECCDDDD?BDDDDDDDDDDDDDDDDDDDDDDDDDDDD@DDDDDD#
@487
GTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTN
+
@@@FFDDDHHHHFGGHIGHJIIIHIJJIGGGGGIIJJGIIJJJIGGIIJGBDFFHIIJIJIIIJH@GHIIIJJJIIJHHGGCDFFFFFEEECEEEFEDEE#
@488
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
BCBFFFFFFHGHHJHIJGHIGHIJJJJJJJJJJJJHIJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJHHHFDDDDDDDDDDDACDCCDDEDDDDACDD
@489
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
@<?DDBDDFFHHDGGIJJIIGGFG@FCCDDGF@FBC:BFHG@BGADGCGCHII7;A<;7=AEAA?@D?D;A=ABDAAAAB>>?:AC@?CCACC??AA:@:#
@48A
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCN
+
@@@DFFFFGHFHHJJJIJJJHJJJGGCHEHHIJJJJJ?DGIFHGIJEH@FGIGJHHHDFFFFFDEDEEDDDDDDDDDDDDDDDDDDDDCCDDDDDDCCCD#
@48B
CTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTTAGCTTN
+
@CCFDDEDFHBDFHIGIEIHICHIIJJGHGIHHHIIJJDGEHIIIJEGBFEHII?DDHIIDJGIJIIJIJJIJJEIGIEGHIIGCFHHFHFFFFFC;CEE#
@48C
CAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCACCAGGATGGAAAAGCCTGTGTACAGGGCTCCGCGGCTGCACTTGCTCTCCGGGGCCN
+
CCCFFFFEHHHHHJIIJIJJJIJIIJIJIIJJJJHJJIIJJIJHHHHHFDFFDEEEEDDDDDDDDFEEEDDDDDDDDDDDDDDDDDDDDCCCDDDDDDDD#
@48D
CCTCTCCTCTCCACACCCAAGGGTCCCGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCN
+
@@<D=ADDFBDFFBDGGGHD;<E+?C??)1:?DDG<9DF@GG;FBDA;C=F@C@DHHE;?CHADEED@;@C3;@C@;/?8&8(9A<?(+(+:4>CC(<@?#
@48E
TTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGN
+
C@CFFFFFDHHHFIJGJJGIIGGHIIIJJJIJJIJHIGIGIGDDGGBGHGIHGIJIJJHBF>FIGGEAFGIHIGIJGAAEHIIE@CHFHFFD@CEACEED#
@48F
CTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCN
+
@@@DDFDDFHHHFIGIGEGEHGIIIIGIJGBHHIBGHGGGIGGJJHHHGHHGHFGAHHFDGHECFHIHHGJAGIJHIGJIJIJHIIFECEAEHFFFFFEC#
@48G
TTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTN
+
CCCFFFFFHHHHHGHIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJHIJIJJHJJJJJJJJJJJJJJJJJJGHEHIDEHHHHHHFFFFFDEEEEEDDDDD#
@48H
CTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAA
+
CCCFFFFFFHHGGFHIAHHHIIJJGIJJIIGHIJGGIIGI3CFFHHIIJJJIJIJJJIDD5<BDDDDBDDDDBCDACDCDDDCCDCDDDDDDDDC?BDD
@48I
GAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCN
+
CCCFFFFFHHHHHJJJJJJJJCGIHIJJJJJJJIJJJJJJJJFHIGHJJJJJJJJJJJJIHJHHHHHHFFFFDDEEDDDDDDDDDDDDEEDDDDDDDDDD#
@48J
CCACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACN
+
C@CFFFDDHHGHAHGFEHHIIIIGGGIIIGIIGIIIIHIIIIIIIIIHIHFCHIEGHIIIGHGGDFEDDDEDDDDEDDDBCDDDDBDDBDDCDDDDDDDD#
@48K
GTTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATN
+
?=?:?;:BDCDBD;CCEE@EFDD8C?F<<B9?DD?8:?DADE<D?DDEDD>D?=>BCEEC>=AE@=4;=ACDD)9<,;?>=:>>5:>;::>>>(4225::#
@48L
CCCAACACTCTGGGTGGCTGAGGCGGGAGGATCACCCGAAGACAGGAGTTCGAGACCCGCCTGACCAACAAGGGGAAACCCCCTCTCTACGAAAAATAC
+
@@@DDDDDACD>:?<@@FEABDHGGG<E@B(=767?(3='3',558(8??:((<?5?(&0;&(++34+(2+(2())0?3<@@&))39:>3<<?<>@(::
@48M
CACTTGGTTGAGTTGCTCTAAGTGGTGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTN
+
???DD>;=C;B:C?4CEEEIIE<4+<++AAC@@EDCEEA<4*??:*0:?DDEEE:???B@DA=B;B)/7=4A@@=CCEIIE;?C>?=);;;;;AAA;(;>#
@48N
CTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCC
+
@@@DDDBDFFBFFFH@AE@H>FEHBHIIIIIEHIIGGHIIIIGGGEFHIHCH@GGIBAH@DEHEC=C==7?H@?C@DCCAAC>@;@CCCBB?BBBCCCC
@48O
CTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGN
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJIJIIJJJJJJJJJIIHHFFFDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDD#
@48P
GCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATN
+
CCCFFFFFHHHHHJJJJJIJJJJIJJJJJIIJJJIIJJIJJJJJJJJJJJJJJJIJJJJJJJJIIJJIIIIJGEGIIEIHHHHHFFFFFFFEEEDEDDDD#
@48Q
CGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGN
+
B@@FDDFFHHHHHJIJJJJJIJJJJJIJIGIJHIJJJJHHHBEFFEEEEEEDDED>CDDDDDDDDDDDDDCBDDDDDBDCDDDDDDDDDDDDCDDBDBCD#
@48R
GTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCN
+
BBCFFFFFHHHHHJJJFHIHJJHIJJIJIJIJJJJJJIJJJJGIJIIHIFFHIJIHIHHHGGFFFFFECEEDDDDDDDBDDD?>@CDDDDCCD@BDDDDD#
@48S
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
<@@DDDDDDHDFFGAEHIIIIFGCFHDFGGGHIIGIHI?DGHBFHI0BFHGGHHFGICDEEHAHFEEEEECCCA@CBBB;@BCCCCBCCB>CCCCCBBB
@48T
CTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCN
+
CCCFFFFFHHHGHJJJJJJIGIJJJJJJJJIJJJJJJJIJJJJJJIJJJJJJJJJIJJIJJJJJIJIIJIJJHHHHHGFFFDDEEEEDDDCFDDDEDDDD#
@48U
CTTTGATCATTAGAATGAGATTCCTCTTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTN
+
@@@FFDFFFHHFFABFIGIHGGGIHFHIIJJIIIIJBFGGCGGGIGHI7@GFGIJJFHFHCFEFFFDDDD@CCCD=:ACDDC9@AC<ABCCCACDDCCCC#
@48V
CTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATN
+
CCCFFFFFHHHFHGJJIJJJJJJFIJBFGIIIJIJJJJIIJC?B;?CCCDCABDDDDCCCCC?BDCDDEEEDDDDDDCDDDDDDD9>BAC@A7?B@ACCC#
@48W
GTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTAATGAGATCTGGAGACAGGTATCCN
+
@@@DAB??A=C::<:CGIEH<F:C+22<<)::*11CD<D9*0B?FGIA>?999BBD*-8.)-//=F77C;D;-?E;.).)).(;6.(;ABB1?B<(5,:,#
@48X
GCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTN
+
??<;BA;DDD7)@?<A?EEE+AAF3C?*?;3?3D0?@2DB9B.)8)8@AAAD?2307<::09(8>>??1)55((2(88&)&(2&&)958<95+:3:>:AD#
@48Y
GTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTN
+
CBCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJIJGIJJJJJJJHEHHHFFFFFEEEEDEDDDDDDCDDEEDDDDDDDDDDACDDBD#
@48Z
TCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTN
+
CCCFFDFDHHHHGJJJGIJJIIIIJJJJJIJJJIJIIJIIJJJJGJJIJDGHHJJIGICHHIIJJJHJJE@FHJJJJJJIHHHFHHHFFFFFEEEEEEED#
@490
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@@@FDADDHHHGHJJJIHJIJJJJIJIJGIFGCFHIJGFIIIJJFHGBHIHHJIJHIIJGIJGIJIEIJGGHFFFCCCCCEDD>AC@CCDACC@CCBD2
@491
GCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGGTTCAGGN
+
@?@DDAD@FDHH?A<EGGCE@HG>HGFGI>G9;?FHGGGGGE?BFHGA6FGIGIGAACB5=?>AD;;>A'(9>CCC(5>>@BBB8@>>?CA@B&)2<CCC#
@492
CTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTN
+
CCCFFFFFHHGHHJJJJHJIJJJJJIIIIGGFHHIIJJJJJJJIJJGIGIJGHDFFDEEEDDDBDDCDDED:ACDDFEEEEDD?BBBDDDDBDDEEDDDD#
@493
ACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACCTGAGGAAAGAGTCACATTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTN
+
@@@FFFFFHHFHHJII<CGCFGIJGGIJBGIIIIJIIGGIIJGGGIIFCGGIIJJIIJHHHHFFFDCCEDDDDDCDDD@CDDDDCCEEFDCCCCCDC?CD#
@494
GCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTN
+
@@@B=DDDAHFHDIHEEHGCHGG??FEFABC@EHHGIIIGIE:G@GHIGCGDHGIICFGGIGGGGCHGHID@ECEHE>CC>;?AC@CCBCAC?BBCC<CC#
@495
CATGGGCTCCAGCAGGATGAACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGGGGTTGAATTTGCTGATGATCAGGGCTTCCN
+
???A;BD??DB?>B?3:?:CD+C@DDIDD?:66BCB;@ADDDC>CCC<??D>>A;@8>:;'<5:,;5>>>(0095>AAAA>A4>>(:(4>ADA:12<?>A#
@496
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CCCFFFDDHHHHHJJJJJJJHHIJJJJJJJJJJJJJJJJJJIHIJJJJJHIHIJJJJJJJJJJJJJ=EHJEEHF5@ADCEEDDDD?BDDDCDDDDDDDDD#
@497
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@@?D?:DDHHHFBFDECBFIIAGC@HIEBFGCBBG<B:BFGCHDBGGCBDDF?F<8C=@@GGDGG=CEHHE>7@@DEEC?<B'8=8,:?CC:A4>BA??>#
@498
CTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTN
+
CCCFFFFFHHHHHJIJJJIJJJIJHIHIJJIIJJJIJJJJJHGIJJJJJIJGGIJJJJJIJIIJIJJJJIJJJJJJJJJJJIIJJJHHFHHFDCFFEEEE#
@499
GTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJJJJJJDDDDDDDDDDCCDEEEEEDDDDCDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDBDDDDD#
@49A
TTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCN
+
CCCFFFFFHHHHGJJJJJIJJJJJJJJJJJJJJJJJJIGIJJJIJJJJJJJJJJJJJJJJJJJIJIJJJJJIIIIJJJHGHHHHHFFDBEDEDEDDCDDC#
@49B
GTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTN
+
@@@ADDDDD=CCCFHIIHCEGEE<AG<;EAE?CCEAFFABF;DH@>FFGEC@>@=@8D@AHA7?B;?CDECCCCDC@@A@C;@;@::A>C;@CCCC@>B@#
@49C
TCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTN
+
???;DBDB,C:C<?,AEA<C4FFIE@EC<22ACE;?E4?*:C?BBB00:9*94B3?D:?D>D<8=)=8@=AC;4@=4@C>===?CA:?37?;@>A;;(;>#
@49D
GTGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
CCCFFFFFHHHHHJJJHIIIJJJJJJJJJHIIJJJJJJJJJIJJJJJJJJJJJJJJJJJJHHHHFFFFEEEEEEDDDD?BD@DDDDDDDDDDDDDDDDDD#
@49E
CTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTN
+
CCCFFFFFHHHHFGIIIGIGJEFFGHJIIIIJJJJJIIGIJJGIHIIGHIEHBGCAGHIJJIHEGIIIJJJJJJHEEHHFFFFECDEEEEDCDDDDDDDD#
@49F
CTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJJJJJFHHJJJJIJJJJJJJJJJJJIJJJJJAEFFAEDEEDDDDDDDDD?DDDD>CCDDDDDDDD
@49G
GTTCCTTCTCTTCTTTCCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGG
+
@@@FFFFDHHHHHIJFBDFIGIJJIHIJBHFHIDHGHHIJIIJJJIIGBHIGHIFIJCHECFGGEGHIJGFHEFFEFFCE
@49H
CTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATN
+
@@@DD=D?BCFFD@GGHGIEGCHH>BH?<F?HIECDHGH>CDFHFHEA4F?GHGDGCBFABFHHBFCGEFHFI@CCH@FHHHGGIFFEHHEDCDEE:?CC#
@49I
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGN
+
?:?D::ADDD<C:?EACACE=E3ACFCFFIIEEE;EDDAADEECI@CBB8;?8DD@B>C45;56A@ADCA?65=>;9>5<:>AA?AAA:>BDDAAA?:>A#
@49J
CACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCAC
+
C@CFFFFFHFDFHIIJIGIIJIIIIHGHHEFHJIIGIJJJIIJJJJIGGIIIJGIJIGHGGIGGIIGJGIJGFEEEEHBFFDDDDDDDDD@CA@ABDC?
@49K
GGCATATGGTTATCGAGGAAAGGACTGGAGAGCTAATGGTTACCTTCTTCCGACCGGGGAAATAGTTTATTTCATTCCATCAGTAGTAGTACTATTTAATN
+
=;?;DDBBB:2A+CE;EEDECB?3?EE)CD:1):9DDC*0*?BB4*?D<DCDADA':=@'';>AA>BAAA>>B;>;(5>3>A:4>A(+((4>DA>:4:A>#
@49L
GTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGG
+
@CCFADDDFHBHHGDGBHDFHIGGHDGEIGGGIIIIIIIDBDFHDHIGHEIGFCHGEAGGHI@GH<=<DDCCECCC
@49M
GGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCN
+
@@@F?DFFHHHFFIJIJJIIIEGIJJIHIJHGIJIIJJJGIIIJIJJGIIHGEHHDFEFFEEECEEDDDBDDDDDDDDEEDCDDDDDDDDDDDDBBDDDD#
@49N
CACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCN
+
C@CFFFFFGHHHH@GHHJJJIJHHIJIJJJJIJJJJJJJIIJIJJJIJIJBHIGEHEHDFFFDEEEEEDCCDDDDDDCDCDDDDD@ACBDDDDDDDD@CD#
@49O
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCN
+
==@DD=?DD?FCFEH@E?EBCB<FEAFB?G>?F?88?DB?=8C=CH.@FHGEH;C.77A;?CDE;BBC;@;>@;C>;A>5::(5A?75=B@@C@>>@(:A#
@49P
CGGGCGTTGAGGGAGGGAAGCGGAAGTGGCTACCACCCGACGGCACTGGCGGGGCACTCTGGGGCACTGCACCCCCCCCCAACCCCCCATCAATGAATGGN
+
CCCFFFFFHHHHHJJJJGIJJJJJJJGIIJJJJJIJJJHHFDDDDDDCBDDD@B5&2+33(:AB0&2+9>:>CBDD&&)5&229BD&0&(++:444>(+>#
@49Q
CCTTTGTACATGCCACAGCTCTCCTACTCATCTGAGTTCCAGTGAAGAAAAGGGCACATTTTAAGCCTCACTGTATTTCTTGCAAGGGCCTGCATTTCATN
+
CC@FFFBDHHHHGIJJIHGGHGIJIIJJJIIHGIGI?EFHIJEHGIGGIICHIFBHIEGGIJIIBHIFIGCEH;DHFFHHHHEFFDDDDDDDDDDECEED#
@49R
CCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTN
+
CCCFFFFEHHHDHIJJIJJJJJDHHIIJIIIJJJ<GHH@GBGIBHIG>FHGIJJI=CHHHHDEFHDDFFF;AEDD?BA@CDDDDDDDDDDDCDDCDDCCC#
@49S
CTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACN
+
=@@;A:D?FF;:DGA?:CHC<::AC;FHHEIEHBCEBB@@9?FDGD?BG?B@BDFGDGIDF@BB@FFIC@FFD;7;??;E>DD@C;;66;;5->;5@@3>#
@49T
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
@CCFFFDFHHHHHJJJGIIBHJJJJJGHGHHIIJJJJJGGIIIJJIIIJJJHGIJJIIHHEHHHFFFEECEEEDDDBD3;BBDDDDDDDDDBDDDDDDDD#
@49U
ACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCACCAGGATGGAAAAGCCTGTGTACAGGGCTCCGCGGCTGCACTTGCTCTCCGGGGCN
+
CCCFFFFFHHHHHJJFIJIJJIIHIIIJJJJJIIJHIIJJJJHHHHHHFFEFEDEEEDCBDDDCCCDEEEDDDDDDDDDDD@BDDDDDDDCDADDDDDDD#
@49V
GTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCN
+
CCCFFFFFGGFAFGIIIJJJIJJIJHIIJJJJJJFIIJJJJIJJJJIIGJJIJJJJIJHHHHEF?CEFFCEEEEEEDCEDDDDDDADDBBDDDDDDD<CD#
@49W
CCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGN
+
@@CFFFFDHGGHGIGIJJIJIIJJIJGIJIIIIGIGGIJIEIJIJIJGEGHFHGGIJHGHHFFFFDFEEDEDEDDDDDEDEDDDDDDCDDDDDDDDBDDD#
@49X
CTTGAAGGCTGCAAATTCTCTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACN
+
@B@FDDDDFFHHFGGIJIIIIIIIIJIIIJGIDDFCDGHIIJGIGGIIHJIJIGHIGIJJGIIGGEHGFHHGHHDEFFEECEDEEECDDDDDCACDCCCC#
@49Y
CTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCAT
+
B@@FDFF@FDDHHJGIIJIIIJJIIGIHJGGIJJJGJIIJJGHJJJIIIJIHHHHGEFFACBCADCDDDD>ACDDDDDDDDCCCDCDCDCDDCACDDCD
@49Z
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFDFFHHHHIHIIIJIJJJFHHIHIJJ:?FHCGGGBGHBFCEH=FCGEHEGFDAEEHHHH?B?B@EEDEED;@CCCCDDD?;CCCCDACCEDDCCC#
@4A0
CCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCN
+
@@@DDFFDHHHDBHGIGGEGIJGEAB?FDF?FEGEGHEIIIIJBAGG@CCECDEBE>BCA?@B@CCC@ADDCCDC?BBBDDCDDDDBDBBB>>@B>C@CC#
@4A1
GAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGA
+
CCCFFFFFHHHGHJJJIIJJJJIJJJJJJJJJJJIJHHHHHHFFFFFEFEEDD@DDDDDDDDEDDEDCDDDDDDDDDD@DDD>ADD<BD?BADCDDDDD
@4A2
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
CCCFFFBEHHFHFHIGIIJJHIIIIJGHGIJIJIIIJ@FGHJJGFHIFGGGHHEEFEHFEDDDDDDC;>ACDCDCDD>ACDBAACDCCDDDDDCACDDCC#
@4A3
CCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGN
+
@@@DDDBDFDHAHGIIGIIIIIIIEHHEHCHIDGDHGI?F@GBGGAFG@EEDGGIG:B>CDEEDCC@AC>CCCCCCCCCCCCCCCCCCBCCCBCCCACCC#
@4A4
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJIJJIJJJJIJJJIJHHHFFFFFEEEEEEDD@BDDDDDDDDDDDDDDDDDDDDCD#
@4A5
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
@@@DDD1BDFHDFCDDGIGAGBABGHIDHH?H06DDHE<FGCHE<F;C@GEDHEHF859>?@C>CA@CC>(:?B8><<>A:ACCC::?CCCC>@AACCA
@4A6
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
CCCFFFFFHHHHHJGHIJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJGIJIJJJIJJJH=DDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@4A7
GGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATN
+
@@BDFFFFHHHHGIIIIGIIJJJIJJJJJJIJJJJJJJHIIIJHIJIFGHIIFHIIGIGGGIIJFFFEDFFFEDEDDDBDAADCCDDCDDDDBD>ACCCC#
@4A8
AGCTGCTTCCCAGCCAACTCACATTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTN
+
@@@ADFFFHGHHHIJIIJJJGJIGIJJJJJIJFIJIJIICGIIJJGJDHJIGHGIECDGIJIGIEEHIIIIGGHHCE@DFEFFFECCDBDDDDCCDEDDD#
@4A9
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CCCFFFFFHHHGHIIJGGGGDHHIJIJJJGJJGHFGIJJJIGDGH<FGGGCBDFBFHGGGGAFHIJ7@EICHGFFEAD>C>BCBD59@CD>CDCCDDDDD#
@4AA
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGN
+
CBCFFFFFHA<AAFGIJIJJJHIIIIGIJJJJJJJJJJJJJJJJJIJJJIGIJJJJJJHHHHHHFFFDDDDDDDDDDDDBDDDDDEDDDDDDDDDDDDDD#
@4AB
CCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCN
+
C@@FFFFFHFHFHJIGGCGGGIGIDHIAFHHCBFGDHGEGHIGGHIGIJJEHIGIJJJJIJIJIGIJIEHGGGGIIGCEGIHCCCEFFFCFEEEECCCDC#
@4AC
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGN
+
@@CFBDDFFHGHGIJBFEIJJJJIIIIJIIJGIJJJJJJIIJJJJJJJJJJIIJJJJHHHHHHFFFFFFFEEEECDDDDDBBBDDCDDDCDACDDEDDDD#
@4AD
CGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
@@@DDDBDHFDFDBEF?@<FAHFHIIIGGBBFGGGGIIIEEFFCFHGGEEG@GHHICEFFFFEBBDCCCCCCCCCCBB,8@5>@>C@CBB>??C@CC>>:#
@4AE
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJFHIJHIJJJJJHIJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDEDDDDDDDDDDDDEDDDDDDDDDD#
@4AF
CTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTC
+
@@CDDDDBHFHFHGHIIICH@GIIBGFGIGCGCFFHIII?FHIIIIICHFGHGBEHCHIIGGGGH@FHIGA=@;DEEECHFEFEFFBAECCEC@CC@DD
@4AG
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
@CCFDDDDHHHGFIJJJJJFHIJGIGIEHGGIJJFGGGGHGIJJJJJIJIJJIHJJGIJJJIJJJIJIJJIIGJHGHHG;BB>CEDACCDCCCDEEDD
@4AH
TGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJCGIHIJJJJJJJJJJJJJJJJJJJJJJJJHHFFFFEEEEEDDDDDDDDDDDDEEFEDDDDDDDDDDDDDDDDB#
@4AI
CATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTC
+
CCCFFFFFHHHGHJFHHHIJJJJJGHJJJIIJJJJJJJHHJJJJGIJHGHIJIIHHHHHHFFFFFEEEEEEEE
@4AJ
GCCGAAAGTCCTTTTTTTCTTTTTAAAATATATTCAACAGATGACCCATAATATTTTTACATTCTGAGCTTTCCACAAGAAATCACTTTCAATAAAACCCN
+
CCCFFDFF<CFFFIGIGGIIIIIIJJJGIIGIDGIIGJJIIJIJIJJIIGCIIIJIJIIAHIGIGECCEHFFFFFFFBBCEEDDCC@CDDDCDECDCCDD#
@4AK
AAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTN
+
?8?DD@?B:ACD;:++<E:A<A<CF,CHHIC2:8BFDB?D@@>GFFEB9B9@><BFE@F888A5A(-7=@E3???E37;B?B@C3>A@3;@AAA<;=355#
@4AL
CTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATN
+
=B@DDFFFHHHBHIIJJJIJIIIIJIJJIJJJJJJJJJJJIIIJJJJJJJJJIIJJEHJIJCGEIHHHHHF@DFACD@BDDDDDDDDDDDDDDDDDDD8@#
@4AM
CTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTN
+
@@?BDDDD>CBDDBBHGHGA?<CE?ECFHGBCC?::?G?D?FBBFHIGEGB9=FGG<FG;@FGCADGCGAAAAAECDDEED>?@CD@?=?BB>;9A@BCC#
@4AN
CCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCN
+
CCCFFFFFHHHHHJIIJJJJJJJJJJJJIJJJJJJJJJJJJJIIIJJJJDFFGIJJJJJJJJIJJJJJJJJHHFFFEEEECEEDDDDDDDDDDDDDDEDD#
@4AO
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@CCFFFFFFHHHGJHIJ?FHFFHJJJJJJJJJJJIIJGIIJJJJJJJJJIJJJJJJJJIJJIJJJIJJHHHFDDBDDDDDDCDCDDDDEEECDDDCCDD
@4AP
TTTCTATAGTAATCATTTTTATAGATGTCTCTGGCGAGTCCAAAGTCTCCAATCTTCACTATCCGTGGACTGGTATA
+
@@<DA;?D?=DB?DHHHIGI=?EHIG<<CDDCHGGBGEDFECDCG?DF9DGHGCDGC>=@CBFCA@C8EEHHEEEBC
@4AQ
GGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGGAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCN
+
@@@DDBEF?HHFDGE@GBGHEEHIFHGFIGHF??EGGGGGG*:BDFEDHIGGGGGICC&05;B??BBCC?<3?@AA?B<?CCCCCCCCC@CCCCBCBC?C#
@4AR
GGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTN
+
@@<DDDDDBDD>F@A@:@@<CFHFHGGGIIIIIIIIABFGIIIIG@GEECAHEDEDEECBB=BBBCCCCCBBBB@?>?+:<4:>@CCCCCCCDACACCCC#
@4AS
CACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTG
+
@@@FADBDHDHGHBB?EEHACFDHI<ADFF@EDBBDF@B?BFGEHEC=;@DHIGHHEHHF>BDEE<=C:>?BDDDDD<CDCDCDDCDB?BDDBDDDDCA
@4AT
AGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATC
+
@@@BDFDFHFGHGJIJIGHIFEHECGGEHIHGHIIIJIIIHGGIIIJGGCHGGGHIJJHFFHFFF?CEEEC@CCCDCCCDCDDBDD9>CCCDDDD@DDD
@4AU
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCN
+
CCCFFFFFHHHHHJJJJJJJIIJJJJJJJJJJFHHIJJHIJHIJJJJJJJJJJ@CGHIJHHHHHHFFFDFFDDEDDDDDEDDDCDDDEEDDDDDDCDDDD#
@4AV
ACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJJJJJJJJGIJJJJJJJJJHIJHHHHFFDEEEFEEDDDDDDEFEEEEDDDD#
@4AW
CCACAGTAGAGGCAAACTTGCAAATGTTTTCCAAATACAATATGCCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIJJJJJ2@FHJJJJHHHHHFFFFFFEEEEEDDDDDDD#
@4AX
AAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACN
+
@@@FDFFFHHHHHJJGIJJJJJJJIIJJJJIIJJIJJJJJJJIJJJJJJJJIJJIIJJJIJJJJIJIJJJJJJHHHHGFFFDDECEEEDDDCDEDDDDDD#
@4AY
CTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGN
+
B@CFDFFFGHHHHJJIJJJIIJIJJJHIIJJIJJJJJJJIGIJIJJFIJIEHHHHHFFFFCEECDDDDCCDDDDDDEDDDDDBDDDDD>CCCB??BDDCD#
@4AZ
CCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTN
+
?@@DD?DDDFDDDHGIIFIEHHHBHICCCDBFGBBEBGCGIIE<CHIGGEHGHEIHEGHIGEGHIC8B8@@CGCHCB=?AAACEDBE@@CCCEA>ACCD>#
@4B0
CGGCCCGTCATCATTCATGGCTTACGATTCTTCAAAGGTGCTTTTCATTGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCG
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJDGIJJJJJJJJJJJJJFHIJJJHHHFFDDDDDDDDDDDDDECDDDDCDDDCDCDC>B<>B
@4B1
CAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
;;?DD3A;C<FA<G<FAF4:F?:;E?DFBDGEBD*8DECFEB6CD9>CD9CCEI=2;=;>;?>3?ABBA;ABABB5>@;<AB@?@?9?@BBB0?@A:@A
@4B2
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCN
+
C@CFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJIJDGGIIJJHIIIIJJJJGGHFFHHFFFFFFDDDDDDD;@BBDD)8CCCDCDDD#
@4B3
TTTCTTCCTTCTGCCCGTGACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCC
+
@@?DD4BDHFH?A<E=8CF@C<A;FFG<EHCD9DDFH@GEEH4<(<@'5CH6@G=??E>B>BA;AC>ACBCC(,>::@<50)024>A@A3+<0<<5<(2
@4B4
GCCGCTTAACTATCAAACGTGTCCATTAATTTTGCCGCTGAGGGTGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGGAAACCCAGTGTN
+
CCCFFFFFHHHHHJJJJJJIGFHIIIJIJJJJJIJGIJJJJJJJDHIGIIJJGJJJJHIIJJJJGHHFHHHFFFFFFFEECEEEDEEDDDDDDDDDD>CC#
@4B5
GTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTN
+
@@@FFFFFGAFHHIIIIGI8GIIDEGB:DAEHIG@AAHIDDDCGGIGCGIIIGGIG=CHFFDC@CCCCB<?CCDCCD:>?BDDDDDC>CDCB?@BDBD<B#
@4B6
TGAAAAAGTGCCTTGAATGTAATTTGCGCAGAGCGCAGGCCTACCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAA
+
CCCFFFFFFHFHGIJIJJJIIIIJJGIIJJJJJIJJIJIIJIIIJJJJJHIJJJIJIJJHHHHHDFFFF?BEEEECDDDDDDDDDDDDDDABDDDD>B
@4B7
TTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTN
+
CCCFFFFFGHHHFHIJJJIJJJJJJJJIJJJJJJGIIJJJIIJIJJIIJJJJJJJJJJGHIJHIJJAEHFFFFFEED;ACDDCCDDDDDDDDDDDDDDDB#
@4B8
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
CCCFFFFFHHHHHJGHJJIJJIIJIJJJJJJJJIJGHJJJJJJJIJJEHHHHFFFFFEEEEEEECBDDDDDDDDDDDDDDDDDDDDEEDCCDDDEDEEED#
@4B9
GGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCA
+
CCCFFFFFHHHHHJJJIJJJJIIIEIIJJIIJIJIJIGGAHIIJJJIGJGJJIIGJGHGIJEIJIEE>CACDFFFFEEDDEEECDCDDDBDDDDDDDDD
@4BA
CCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCCCTCAGGAGGAATCCAAGGATGGGGGGTTCCGCGTGGGGGN
+
?8;BD<1@<DFFBGEB?CE33329<EBCBE<@D))8)?:7-;8))/..=C77=C>C3=AB(4(9.6;(5/;(::5(,:<9:(8?BB3)&+(&&&&&)99&#
@4BB
CCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
@CCFDBDDFHFDHIJFGGIIJJGJJJJCEFHIGHIFEDGGIGGEHGEEDFDIIEIIGGGGFHGGIJIIGGEGGHIEHDGGCHGHFFFCFFEE@CDEEE
@4BC
CGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGGGATATAACTTCACTN
+
@@@DDDFFBDDFHEAHHDHFDFGFHAHGFGIIFHD=?B@@)5?8@CACDDDDBD8@D?CCA?A?<<?B>@9>CC@B?@DBDD@@CA?8:?>AA>ACCCAC#
@4BD
AGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATN
+
CCCFFFFFHHHGHJJJIJJJJJJJJJJJJJJJJFJJIJJJJIJHIJIIIHJJJJJJIGIJJJJJJJJIJJJJIJHHHFFFFFFEEDEEDDDDDDDDBBDD#
@4BE
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
;??BDDD?DDC+<E??1@CE@+AEDFBB<*?49D??DDDDDD0186A'5AC@AA@;?A@@>>AA?923(;/,',093>AAA89>A>>>A3344+4:(44:#
@4BF
GCATCCAGTAAGTGTGCAGGATGGGCTTCGGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGG
+
:=?DDDAD?D?BAFHGIGII=D>FFHIGG1CFHGG9GHIEEGIIIEGGIGGHIGIIEGIGI;FHHIC>CA>EFHHE@C;?BECCB;6;5ABB3=28>@A
@4BG
CTCCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTC
+
@C@DFFFFHHHDHIJGFHIIIJJJJJJIFHHIJIIDCGIIHHIJJJIGIJJJJEGGIHIIJJJBDFDHIGGHGGEIJJJJJJIGIHFHEHHFDCEFFFE
@4BH
CCACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACN
+
CCCFFFFFGHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHFFFDDDEDDCDEDDDDDDDDDDDDDDDDDDDDDDDD#
@4BI
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJJJJJIIJJJJJJJJJJGHJJJJJJJJJJJJJJJJJJJJJJJJJJJHIHIHHHHHFFFFFFEEAEEDCCDD8?@DCDDDCBD8AC
@4BJ
TTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTG
+
CCCFFFFFHGHHGIJGHGJIGHJHIIGGEEHGEHIEBGHGHJGIHGGEGHHIJJJIJJIJIGIIJJGGIIEFCBBDDDDDDCCEC@>CAACCCD:@B:?
@4BK
GTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGG
+
CBCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJIJJIIJJJJJJJJJIJJJJJJJJJJJJIJJJJJIJJJIHIJJJJHHHHHFFFFFFEEDEEEEEEDD
@4BL
CGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCN
+
CCCFFFDFHHHHHJIIIIIIHIJIIJJJJJJJFIJJJJJJJJDFHIIJJJJIGHGIJJJJGIIJJ49?ABCDDEDDCDB@BBDDDDDDDCDDDDDDDDDC#
@4BM
GTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGN
+
@@@DDFFFDFHGGGIIF<CGCGH@GEHI?CHIIJJJIBCGHGHAHHAGIGIIFGHIIGHEEEHFFFFFDFEEECCB?CDDEECDDDD?CCDDDDDDDDDD#
@4BN
CTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGAC
+
CCCFFFFFHHHHHJJIJJIJIJJJJIJJJJJIJJJJFHIIJIJIJJJHIJIJIJJJJIJJJJJJJIHHEEFFFEEDEEEDCDDDDDDDDDDDDDDDEDD
@4BO
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTN
+
???D;:D>:=:C2?+<?@8F?EEE>CE8:CDD?DDCE<DDDAD??98?8=CE)=@;8).)8AA;=AA6?@A);77;6>:;??23>A53>A,>>>:>:908#
@4BP
CTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCN
+
CCCFFFFFHHHHHJJJJJJJIJJIIIJIJJIJJIJJJJIIIIIJJIJJJJJJIJIIJIGIJJGIIJIEIIEEEEHHHFBDEFFEECCEECCDDC>@?CBB#
@4BQ
CGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCN
+
@@@FFDFFHHHHFIBHGGIIIEHFFHGIJJIJIEIJJICHGGIDHGEIIIIGCEHJI7=EHFDDACADCCCCDCDDDBDDDDDDDDCDBD@CCCDCCCCC#
@4BR
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGN
+
@@@FDEFDHHHHHGDHFGIIFGHGIJIIIJJJIIIJJGHIJGGIJJGHDAFIFHHHIHGGFAEDFFFBCEEEEACCDDDDDD<@CDD@CDCCC>ACDA@C#
@4BS
CTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAG
+
CCCFFFFFGHHHGIGHEGIJIJHIIJIGHIEDFHCGGHIHIG8BFHIIGGGGHHHHEFFDDBBCCDDDDCDDDDCDDDDDEEDDDDDDCBBCCDEEDC
@4BT
TTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTN
+
CCCFFFFFHGHHHJJJJJJHIIJJJJJJJIJJJJJJIJIHIJJJJIJJJJIJJJJJIJJJJJJJJJIIIJJJJJJJJJHFHHHEHFFFFFDEDEEEDDED#
@4BU
GTGGGATCTCCTTGGGTGCCTCAGGAGCAGGAGGTCTCTGGGCTTTACGCTGACGCCGGCGGGGGGCCCGTGTCTTGGAGGCTGCCTTCTTCGGAATGT
+
CCCFFFFFHHHHHJJJHHJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJIIJJJHDDDDDDDDDDDD;;??CCCD@CB????DCC@CCC?BBDBCC
@4BV
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJEFHIJIIJIIIIJJCGIIHIIJJJGIJJJIIJJJJGHJIJJIGEEHHHHFFFEEDC@CCCDDCCECDDCBCCCCCDDCDD
@4BW
CTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTTCN
+
???DDDDBDFBHBG;?FDFIEHIGGGFHHCGG=EGGIB?GGCDHIHCDHIIIIIGI;CGCHHHHE=7?@EDDCCACCCCCCCCC(5>>CCCACCCCCBBC#
@4BX
TGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAG
+
@@@DDDDFFHF?FHDGHIJJFIEGGGHIGEDGIHEGHIJFGIJJIIJIJGHIHIJIGGIGIIJJGIGIJGFHHGF?>ACEDDCDDDAC@@@CDDDDCB
@4BY
GCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATN
+
CCCFFFFFGGFC<AACFHIIIIJIJJJJIIIGHIJJGIJJIGIJIJJJJGIIJJHJIIGGGIJIIIIJIIJJJAEHHFFFFCEECC@CC>@@5@ACCD@C#
@4BZ
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCN
+
@=?DBDDDHFDHAB?EFHEFFH>EBGHDBBBAFGEGIDGIG@CFEGGBF?F<>*8DEEC@F73476.=;7??;7=7?B3;7?C;;>>AAC((;;5?58<A#
@4C0
CTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATA
+
@@@DD??=2=ACD@GDFBFF>@:<B@@+A99<CFFGIFF?B<FFF9@4:?*0*??BG8BF2D?CFG<FFG:FAAEAEEE;DD>?=2=;@B@BDAC>A;A
@4C1
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
@@CDDDFDFFFHDGGHJEGHIJGJBHGGGGGIBDEHGIGIBDHEAAGFGIEGADGGE@@@C@D@CCCHEEHE@B@>>>;AAC@CCDC;@8<@<?@(05&2#
@4C2
CGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGG
+
B@CBDFFFHHHHHIIIJJIJHHIJJJJJJJIJJFHIIJJJJGIJJJIJJBGIJFHJHEHFFFF@DEEEEDEDEDDDDDDDDDDDDDDDDDD<BDDDDDD
@4C3
GGCAGCAGAGAATTCTGGTTCCTAAAACATTCTTTCCTCTTTTGTTGGATGGGAAATTCCATTCTGTTCCACATCAGCTTATGCATTGGAAATTTTGTATN
+
CCCFFFFFHGHHGJJJJJHHIJJJJJJGIIJJJJJJJGIJJJJJIIIJGGHIJIIHJJJGIJJJJJJJJJJIJJJJIHHHGHHFFFFFFEEEEEEDDBDE#
@4C4
GGCTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCN
+
@@@DDDD?DFDHDHIGAGCE@HHEGIAHHIICHIDDACH?DFH*?DFG@FHHDDFEEC;EGECEHHEEDDECC>@C?3@CA(5?B:<A9?:@:>C:@:@@#
@4C5
TTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTN
+
@@@DDFFFFFHHHGHGHGICFHHIIGGHHEHEEIIEGIIIGIJJD@GDH<BGHIIHHIJGGF@GCAGHIJ<CDGII@GDCGIE==AAAE=>@DDDCDFEE#
@4C6
TAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTN
+
BCCFFFFFHHHHHJJJJIJJJJIJJJJJJJJJJJCGIIIJJJJJJJJJJJIIJJJIJIIJJJIEIJDBDDDEDDDDDDDFDDDDDDDDDDDDDDDDDDDD#
@4C7
AGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATN
+
@@@FFDFFHHGHHIIIIGHIIJJJJIJGIJJJJIJJJJIIIIJIIEGGDFHGIJGIIIJJIJICCHIGGHH;BDFCCEDEDD;?CCA:AACDDBACDDCD#
@4C8
ATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTG
+
@@?ABDDDDD?FFEHG;;CGG@?DHDGIGEGI<??67.-=88)5.55=@.==@AEE===@B;;?CCCCCCC;A3?;>@>5@55,9?8?CCCCC@CCC??
@4C9
GTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGN
+
@@@FFFFFHGGFHGGECFGHFHGGIJIJGIGIJJIIIJCDFHIJGIGGIGIIGIIJIGEFFC>B:<@BB>BBDBDBDDDCDC<>@ACDDBBB<@BDD>@B#
@4CA
GTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTN
+
BBBFFDFFHDHHHIJJJJJJFHHJIHIJJJJJJJJJJJJJJJFHIIIJJJJJJCEHJJJHHHFFFFFEEEFEEEEDDDDCDDDDFDDDEEDDDDDDDDDD#
@4CB
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
?;;AADDDA4D?CGEAFBGGIIGA??:FBFEFB?B@GG<FDHDCFH?CBG@AAD@@E@77@?E8,,=3>@ACAA?;;??>AAC@@@@>@CC?B5)5??:C#
@4CC
GGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGN
+
CCCFFDDEHHHHHIJIIIIICFH@FHIIJJJIIIJJJIIJJJJIJJJJJIIJIHIIJJIJJJJJGHHHGHHHFFFDDB@@CCDDDD@CD@BDDEDDDDCC#
@4CD
TTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGN
+
CCCFFFFFHHHDDHGHEGIIJJJJJJJJGGIIIJJJIJJJJGFGGHFFFFEE@CCDBCBCDDEEEDCDDDDDDD@BBBACACDDDCDDDDDDCCBCDDDC#
@4CE
ATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAAC
+
CCCFFFFFFHHHHJJJJIJJJJJJJJJJHIJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHEDEFFF@CEEEEEDDDDDDEED
@4CF
TGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTN
+
?@@DABBDFF?BFAA?CEC3C3AFHEFEF881::C:?9D;BG>?4BGF??B@FBBF;@8C=;C>@D7=7=?AEAE>;2;??@C;?(5@;;55>A@>@AAA#
@4CG
GCGGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACC
+
@<@FFDDBHDDHHIIIG;ACHIIEBCFC?FF??FHHHCHACDDDHHIEHA;@=@C@;@C;C@?A=7=CDD?BE3=6@;A5>>;@A?A?BAC@:AB:@CC
@4CH
CTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGA
+
?@@DADDDDFBF?G2CGGGHEFGCEFHBHEGCHIII@GEHII=FHII8CAH?);;CGHEHHEECDDCCC@AB==@CAD>;@C@CCCCCCCA:@CCCCBC
@4CI
CTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTN
+
?@@DDDBDDHDBDDGHGIED@GHEHHGE<EEGGIFBHGHEIGFHGBGGHIDHHIEI??CGGGCC@CGGCHGHGIE?E>EE@;?>@BDEECCCB@A@:>>@#
@4CJ
CCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTN
+
@@@DDDFEHBC?FHGICGEHGEGGIEGIIFHBFCFGBCGG@BDEEFGGHGIIIIIG=FCGGIHIGIIIHEFEHFFFFFDFCEEEC>CBC@C;@@BCC@CC#
@4CK
GCTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCC
+
CC@FFFFDHHHFHFGBBFEEFE@FHGGIIIECDFGCDHCHIIIIF@GDCHEEI@CB8BGCDHH@HEDGDEH>59;?9>ACDCC;>?<?29<?<?C>AB?
@4CL
GAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCC
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJGHFIIIIIGIIJJJJJJDFGIDHIJ;CHIGJJHFHH?DFFEEEEEEDDDDDDDDDDDD=@DDDDDD
@4CM
CCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTN
+
CCCFFFFFHHHHHJJJJHIJIIIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJGIJJJJJJJJJJJJIJJJJJJJJIJJJJHHGFDDCEDDDDEEEDDE#
@4CN
CCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGN
+
<?@BDFFFDHGHBH@GHHHHGBEH@FDHA<?FHGCAHGIIGF<<B>GEHGHEIDHIIIDHGIIIG@@@=@(=:=<BBC>>ACCCCCCCC9CCC>ABCABB#
@4CO
CGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTN
+
CCCFFFFFHGHHHEGIIJJJJGEIIIJJIJJEGHIJJJJJJJJJJJJJJJJJJJJJJCGGIJIJHHHFFFDEEDEDDDDDDDBDDDDDDDDDDDDDDDDC#
@4CP
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
@<@BDDDDHHFBD:BGG>FEEHGBHHBHFHCEEGGFCFGHIB)?FH;B==CAGIHGII;A=;@;@AC@=@CC@@A;>@CCCCC9@CCCCC@CA:@CCCCC#
@4CQ
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTN
+
CCCFFFFFHGHCFGHCGIGIIIIIIJJJJJJJIJJIIIJJIJIIJJJJJJJJJFHHHHFFFFFFEEEEEEDCCDCFDDDDDDCDDDBDBDDDDDDCDACD#
@4CR
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@B@DFFFFHHFHHIHGIFGIFHHGIJIIGIJJJJHEGIJIJJIJIIJIGFGHIJIGIJGHIEEHJJIIHHHFDDD@DCCDDDDACDDBCDEDCCDDCCD
@4CS
GTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCN
+
@@@DFFFFGHHHDEEHHHIIIIIIJJIBEHHHE>GIIHHJJIHIFHHIIJJJ@HGIIJIIJDEHGEHHFHHFFDFBCACE@AACDDDDDDDDDDEDBDB?#
@4CT
TGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGCATTTTCGACAATTTATTACGGCTATCATCTG
+
@@@DDDBD?<BBADFGEFC@>FEH??@<B@FDHEGBCDH@DF@BB60?DF>?DGH:FDDF0B=FHIE267CHGHFCEBBCC;;C@@>?8@;<@(5;:@:
@4CU
GTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGN
+
C@CFFDFFHGHHHIJJJJJJJJJJJJJIJJJIIJJJJJJJJJJJJJJJJHIJJJHHHHFFFFFFEEEEDDDDCDDDDDDDDEDDDDDDDDDDDDDDDDDD#
@4CV
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@=?DBDDDBFD?B<<CBEHECFEHHEGEBFHEGHHIHECCH>FGAGIEGGGGDHEHDBFD=<BFGICGIIIGE7=?DDEC>C@ACA>ADDCC@CCCBB?C#
@4CW
GTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTA
+
@@@FFEFFHHHHFHIJJGIJIIJJJJJJJJIJJJIHHIIJIIJJJBFHIJJJIJJIIIIJJGHHHHHHHFFFFFEFEEDEEEEDDDDDBDDDDDCD@BC
@4CX
TTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAA
+
CC@FFFFFHHHFHJJIIJGHIGGIJJJJJJJIJIJJIIIIGIIIIJHHFFFFFDDDDDD;ABBDCBDDDEEEDDDDDDB<?B>BD?CDDDDDDDDDDD
@4CY
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJIJJJIJJJJJIIJIJJJEHHFCEEEEEDCCDDDDDDDDDDDDDDDDDDDDDDDD#
@4CZ
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGN
+
1?;DADDABHHFHFAG@FHFH@BHFHEHIIGDHGCFEH>G?GGH??@FHGGGBACF<FA8=@FFH<AAEEDBEBD>>;,5;;>@A>@>CB<<@BACCBBB#
@4D0
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
CCCFFEFFHHHHHJJJJJHIJJJJJJJJJJIHIJJJJJIJJJJJJJJJJJJIIIJJJJJJJJJJJJHHFFFEEEEECEDDD@CDDDDDDDDDDDDDCDDD#
@4D1
CACTGTTGTTTGCTTCATCTCTGGACTTATAAATGCTATTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTGAATTCTATGAAAAGTAGGTCTTTGN
+
@@@FFFFFHHHDHIIJJJIJJJIIIIIIJJJJJIGIGIJJJIIIJJIGGGIIIIIJJIIGEIIIJIJGIEHIJGIGHHHHGFFFEFFFDC@CECCCCDDD#
@4D2
CTCCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCN
+
CCCFFFFFHHGHHJIJIJJJIIIIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJHEHHHHGFFFFFFFEEEEEEEDD#
@4D3
CGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTAATCTTGAGGTCTCTG
+
;;?DB=DDDBDD4<<,AE<3C9:C;?@FE9FF<DEDIBD)?CBC>D9;D@*999D?9D8DD=BCEBDB@7.=).).=:;CA=)=AC;
@4D4
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
?@??:A?:DF??FEEGE@GGCH@HIIGAACG@?FB??FGHAF<BAD8B;FH6FHGCHICCD@AEE>;CBDBD@A26@CC>A?=@<?9?35:@>>A>3:
@4D5
GGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTC
+
CCCFFFFFGHGHHDHIJJJJJIIJJJIJJFJJJJIJJJJIJJJJJJHIJJIJJJJJJJCHHHHFFFFFEEDEECCDDDCDDDDDDDDDDDDDDCDDDCD
@4D6
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
CCCFFFFFHHHHHIJIHIJJJJJJJJJIIJJJJJJIJGIFHIJJJFHIIIIJIJIJJJJH?EHGHFFFFFFEEEEAEDDDCDDDDDEDDDDCDDEEDDDD#
@4D7
TGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGG
+
@@@FDDEDFHHGGIGHIGGGGHAECF?FHIJIIDGIJJIGIJ9?FHIJGGIIIFAGHIGGEHFEFFFDDDDDDDDDDDDDDCCDDDDCDDEDCCDDCCD
@4D8
CCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGTAATGCACTCAATGACCTCCGTGTTTGAGAGTTGG
+
@?@B=DBDDDHHBHEBGEHFHFHIIIEFADD@ACFHIGA@<FGAA=EFF@CAC?C;;?@BCCDD8>ADC@@CACCC>CCCC>CB@BB8ACD>@DCDEDD
@4D9
CCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATN
+
CCCFFFDFHHFHHIJIJJJJJJJJIGIJGIDHIJJJEFHGIIJIEHDIGIIHHHHHHFFFBCDCCDCDDDDACDDDBDDDDDDCCDDCCDDCDDDDDDDD#
@4DA
CTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACGCTGCCACTGACGGAAGTTCTCATAAACGTCCTTGGAAATTTTGGAGCGGTCACCTAGGGAAGGCN
+
CCCFFFFDBBA?DGEDBFADDGHIIGIIGIGBGE<B?B67BFFICC@@BECA=A>CA;BBBB>;;A;?CCCCCCA>CCA6>C?@>99<C@A>>>ACBB@B#
@4DB
CCCCGCAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGC
+
CCCFFFFFHGHHHJJJJJJIJIJIJJJJIJIIIJGGJJJJJIJJJJIGIIHHHHHHFFFFFFEDEEEDDDDDDDDACDDD@?CDDBBDDBDDDDDDDDD
@4DC
GGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCA
+
@@@D?BABF4A:A::4AFF9AF<CFHE<3CF?+CE<3C9<D<?G<9*9?D9?F?099?DD4B<*?=B=(;@FFD>7@EF@>CE?C;AB?3@@@@C;>AA
@4DD
CTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJHHHGFFFFFFEEEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDD
@4DE
GTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@@FFDEDBBBBH<CF<AC@ACEBFIGB@HEGGECEDGEBEG@FDFDAD>GHICBFHDDF=DE@@GHIHHFEB@959>ACC?CCC:>@CDC@C@CCCB
@4DF
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJHJJJJJJJJJJHIJJJJAEHFDEDEEEDCDDDDDDDDDDDDDDDDDDDDDCDDD#
@4DG
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
C@CFFFADFHFHFHGHIJIIIHHIJFJJIGHIJGGJFHIGHIJJGIIJGHIJGGIIHIIJGHIJJJ8AHHHCHEEDFDFFEFEEE@C;>B=BC?BBBDD>#
@4DH
GTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCN
+
@@@FFFFFHHHHHJJJJJIFIJJJJJIIJJJJJIJIJJJJJJJJIIJJJJJJJJIJJJJHHHHHHFFFFFDDEDDDDDDDCDDDEDEDDDDDDDDDDDDD#
@4DI
AAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTG
+
CCCFFDFFHGAHGIIIIJJJJIJFGGHIGIJGGGIJIIJFIHFFDEEEEEDCCDDFDDDDBDBCDDDDDECCEC@CCCDCCDDDDBDDDABDDBDD<B
@4DJ
GCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGAGAATCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTN
+
;@?DB@DD:CA?:EBEDG<ACDCB19A<DF)1C11?BEFEFFI@GF>(=8)/8)8CFE9E)=@C==373??))6@36>B:@;;@((5(,8?8A7<?993>#
@4DK
GCCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAAT
+
@<@ADDDA8DDDFHEGADBHGDCG@<FF;EBFG:C?;FEDFH@>9BBC?BAGGHEABFC@F;CGG;C4=@@>E>EEC;@77.,9=??(,,55>@9AB:
@4DL
GCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJHHHIJJJJJJIJJJIJJJJJJIJJJJJJJJJJJJJJJGJJJJJJJJJHHFFFEEEEEEDDDDDDDBDDDDDCDDD#
@4DM
GGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGG
+
@CBFFFFFHHHHHJJJJJJJJJIJJJJJJJJJIHIJJJJJJJJJJJJJJIJJJJJJJJJJJJIIIJJJJJJJJJJJFDFHGCFFEDFCCECECECDEDD
@4DN
GTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCN
+
=?1=A4?DBAD?DB3C@6CFDAAFFEIFFA;DE;'('3/=;=???@B/8<98588B<(5?:(:>BBDD4:>AB:3(9(5?9<@AAB>A??BB29?8AAB?#
@4DO
GTCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATN
+
?=@;DDD:CFFHHI?FAFDCFEGFGEGIG@HIIBBEFHBDDAFG?FFF@FCGIIGCCDCCEGHGH>>=?>C@A>DCCC@ACBC>>>-:>CCDDCC880<8#
@4DP
CTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGN
+
CCCFFFFFHHGHHJJHIJJIJJJGGHGEDFGGHCFHHIFGGIIGIGJJJBFDEGHJFHIJIGIIIHIGCDGGIGGIF2ADFDD?BDBDDDD<CCCDD@DB#
@4DQ
CAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGACAGCAG
+
@@CFDFDAHDHHHDFEHIJJIJIJGIJGHIFFGDHIIIJFFIIIIIIIIIIIJIIIJJIGIIGIIIDBEB?DEDEEDDDDDDDDBBBBDDDCDDDBDD
@4DR
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGN
+
CCCFFFFFHDHHGIHGGIJIJIJJJJJJIHGHJHIIIJIIJIIIIJIIJIHJJIGIIJIGHHHHEEFFFDFEDDEDDDDCCCCDDCDDDDCDDDDDCDDD#
@4DS
CCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGN
+
@@CFDDFFHHHFGJJJJJGIGIIGIHGIIHGJIJJIG<FGD@GCGIIGHGCGHCCHDHHEEFFFCCEDEEED>@??BDCACCECCDDDDEDCDDDDDDDB#
@4DT
CTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
CCCDFEBDFFFFHHIHIGIJJIIIJEHIGIJIIIJJJJJIFHHHIFGHEFGEGBEHB>AGGCHC@;@@EGEEEEFABCDFFFE(5>AAC;AC>CCCDDD
@4DU
AAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCT
+
@@@DADBBFBHDFIIACFCA:CGB?0@FGGCDHCDFBHHGAHHBB4=??AB;95?CC?9>>CD>CCC>:>??8899559?<8A@>>
@4DV
GTTCTCCAGCTGCAGGTTCTGGGAGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCN
+
@@@DDDDDHFDHAGHIBDHCHHIIII??DGGIHGGGCGIIICCFIGGIIIIGHIHIIICEFEEEEEEECC>@CCABB2;B5?B?ACBBBBAA?B5<B0?8#
@4DW
CTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATN
+
CCCFFFFFHHHHHJJJJJJJJIJFHJJJJJJJJJJGHHIIJJJJJJJJJIIJIIJJIJJJJJJJIIIIIJGIJJGIJHHHHDFFEFDEEEDCCDDDCDDC#
@4DX
CAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCN
+
<@@DDD?DHDBDDGEGECIHGEGGFGGAEEGHIII)@F?B8?F=BCA@ACG@EA@EEFH>E>@DB<>ABCCCCCCCCCC;;CBCCCCCC>A:@>ACC@C?#
@4DY
GCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCN
+
?;<D7B>;=BD?DEE9+<CDF:AE<3CE<EE<CF<ECEEE;?DCD9?B7<?DDDC89@(7A-8;ADC==AC=?=7AACAA@;,5;;;(:A(:5>>A:>A3#
@4DZ
CTAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCN
+
BCCFFDFFHHHHHJJJJJJHHIJJJJJJJJJJJJJJJJJJJJJJJJJJHIHIIHIJJJJJJIIJJHGIIDHHF5@BDEEEDDDDBBDDDDDDDDDDDDDD#
@4E0
GGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGN
+
CC@FFDFFGHFHHIIJJIIJJJJIECGDCDGGDHGIJGIJEHEGGGIIIIIHIGGIIIHHHGFDEFE@CCEE@BDBACBDDD<?@CCCDDDDDCBDBDDD#
@4E1
CATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCN
+
@@@DDDBB;CBFHIIIIEHIFIIIBHEGEEEHIIIDIFGBG@DBHEAHHFFGGIE@A@DGE=?BDEEECCB3;=@A>A@>@AB?ACC@@CCC@CC@CACC#
@4E2
CTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCN
+
CCCFFDEFHHHHHJHIJGIJJJJJIIHJJJJIIGIIIIIJJIJJJJIIJFHFIIIGIJIJJJJIIJJJJIIIIJJJFHHHHHHFFDFFFDEEEDDDDD@C#
@4E3
CGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCAC
+
@@@DAA?DHFHFHIIBEGH>FF@:CFHHIGIIIIIIIEGIIGGIIIHHCCHIGIIHIGIFHIIIIIECCHH;BDEDCCCCCCCBBBBC:@CDECACCCB
@4E4
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
@BCDDDFFHHHGHIJJJGIJIIIGIIJJIJIJJIGIGGGIJIJJJIGIIHIJJJJGGGI7BDHEIGHHEAHHFFFFEEEECCDDDDCCD<BCBBD59@9@#
@4E5
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTN
+
CCCFFFFFHHHHHIJJJJJJIJJJJJIJJFHIIIJIJJIIIJGIJJ?FEHHHIIIJJEIHHHFDDCEDEDDDDDDDCDDDDDDDDDDDCDDDDDDCDDDD#
@4E6
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCDFFFFHHGHHEHJIIJJJJJGIGICFFHIGIIIIJGHJBFHHGJIJIIJHGIIJIGIJJGHHGIDHHBEDBEEEDEEDDDCDDD5>CD@CDD29?@
@4E7
CAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
CCCFFFFFHHHHHJJJJIJIJIJJIJJJJHIIJJ?B@GIJJJJIJJJJIJJJJJHHHHGFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDEDD
@4E8
TTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTN
+
@@@FFFFFHHADFIIIIJJIJJJJJIJIJGHFHIIJGHIIJIIIGIIIIJIJIIJJJIGGIHIJIDBFHI@GGIJJFIHHHEHGFF@CDEF@@CACEACD#
@4E9
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
CCCFFFFFHHHHHIIJJJIIJGHJJJJJJJJJFGHHIJJIJJJJIJGHIIIJIIJJJJJJJIJJJJIJIJHHHFFEE@DEDEDDDDDDCDDD<CDDCDDD#
@4EA
GTTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCC
+
C@@FFFDFHHDHHIJJJBFFHIIFHIGIIIIGIHIIFIIIIJHIFGIEFEGHIJJHGIJIHJIJJGHIIGIGIJJIGIHGFFEEHFFFFFFEEEE
@4EB
AAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTGATGATAACATGGAAGAGAAAAAACCCATCCTCACCATCGCC
+
C@CFFF@DFHHHGIIIEHGCHGBEHCGGEHIICHGGGDIIIIIIIIIII@GG@FGIHGHG>FG>@EHEGG;AEEFFDDDDDDDCCBDDDDDCCDBDB
@4EC
CGAAGTATATCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGN
+
CC@FFDFFHHHHGJJJJJJJJJJJIJJJJJJJJJJIJJIJIJIJIJJJJJJIGIIJJJJJIJIJIJJJJJIHHHHFFFF>@DD;CCDEDD@CDDDDDDDB#
@4ED
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
CCCDFFFFHHHFHHGEGBHIDEHIJJIIJJIJJIHIJJGGIJGIGHG;DFGIIIJIIJJJEIGGGHCEBBDFFDEFEECCC@??BBDCDCDCACCDD4:?#
@4EE
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
CCCFFFFFGHHHGIJFHHJJJJJJJJIJIJJJJIIIIJIJIIJJJJIJJIIJIJIGFBHIFFHGHFFFFFFFEECEEDDDDCDCDDDDD:?B<@CBDD9<#
@4EF
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJJIJJJIIIHHHHHFFFFFFFDDD9?DDDDDDEDDCCDDDDD#
@4EG
TTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTT
+
@CCFDDEFHHHHHJJJJJJIIJFHIGGIIIJJJIJJJJJJJJJJJJIJJGHGIJJGGIIJHHFGHFFFFFFFECEECEDDDDDDDDDD
@4EH
CTGGTATAGTCTTTCACGGAAACAAGGCAATTTCTAGCTGCCAGATCCCTGTGAATGAAATGCAAGATCGGAAGAGGTCTGAACTCCAGTCACCGATGT
+
BC@FDFFFHHHHHJJJJJIJJJJJJJJJJJJJJIJJJIJJJJJJIJJJJJJIIJJJIJJJJJJJJJIJJJJGHHFFFBCCEEEECDDDDDDDDDDBBDA
@4EI
CTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCN
+
@CCFFDFADFHFHBFHEHEEGGIIDHIEIIHHI?DBAHI>GABBGCHIIIIFE<FGHGHIIHG;;;@@@GA>ECEECEBBCB@DD>A>CCCECCCCC@=@#
@4EJ
GCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGN
+
BCCFDFFFHHHFHJIJIJGHIIIIJJJJJJJJIJHIJIJIGGIIJJJIJJJJIGIIJJGIJIIGGIIIJJJIJIJIJIJHIIIJJJIJHHHHGFFFFFBC#
@4EK
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
<@@DDFDFHGHHHJJIJICAEGIHHHFIIIIJIGEGHCHJIGHHGEHJIGHHIIJJEHGJJGHGBHIIGHHIJIF>ACE;?AC@CCDCDEDCCC@DCC
@4EL
TATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTN
+
CCCFFFFFHHBHHJJIIJJJIGJGHHJGJJJJJJIIHIJJJJIIJHIJJJIIJJJIJJJJIJIIGGEHHFDFFED@BCCDDCDDDDDACDDDDCDDEDDD#
@4EM
CTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCN
+
@@@DDDDDAFAAF?:3<ACGEFFEF>??EFF?D>FBFGFFEAGGIEIEBFEFFFGII:=@=FCEE;5=1:8@;>>BA>AA5;;;@BBAA:5:>5>@>(:>#
@4EN
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
@@CFFFFFHHGDHIIEIIIJJIIJIHIJJGHGGIIHIIHIIJDFHIBHIIJJGHGGIIGGFDFDEEDDDCDDCDDDDDCDCDCBDDDDDDCCDDCDDDCC#
@4EO
CGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTN
+
:?8B==AD=DFFHIHEEFHF?CAFHEHCFBAHF?::DHFEHGCAFHGCHIIGICBBDCBFGHIHE>FD=6=.=GH@GI>EHA==>ECBE7@@D>@CCC9@#
@4EP
CTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTN
+
@?@BDDBD?A?CDE@FHIDIIGGHGGGHGID>D@DHI@HFDABFHH<FHHCECHGAHG@CGH;@7=DEB<;@B??(39;?@2<@CC>:;>:>@@>C4<B<#
@4EQ
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
@CCFDBDE8FHDFFHIHJJJEHIGGGHIGGIHGIJBGGGGHGCHHGDFHCGCGIGGGHDGHHEHF??;A:>>A@CD;>;ABDDCCACDCDDACC4>>8?A#
@4ER
CCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGN
+
CCCFFFFFHHHHHJAFHJJJJJJJJJJJJJJJJJJJJJJGIHIJJJJJJHHHFFFFCEEEEEEDCDDDDDDDEDEDDDDDDDDDD>BDDDDDDDEEDEDD#
@4ES
TGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTG
+
BBCFADADHHHHHJJJJIJJFBDBBBDDDD;<BBDD3:@CDDDEDDDDD@DDDDDBDD8ACDDCCDDDCCCDDCDDD>BDDDDDDDDDCDDBDDBDD:A
@4ET
TTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGN
+
@@@FFFFFHBHHGJIJJJFIJIJI?FHIJIIG@::?FBHIFEGG@FG@;FHCHI@@CHGEECEFFFFCCECCCEDDDEECCFCCCCCDDBBDDDDACCCC#
@4EU
TACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIIJHJJJJJJIJJHIJJJIJJJJHIJFHIJJJJJIIJJIHHHGHFFFDEEEEEEFDDDDDDDBDDDDDDDD#
@4EV
CGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJGHIHJJJJJJJJIJJJJJJJJJJJJJJJHHHFFFEEEEEEDDDDDDDDDDDDEEFECDDDDDCDDDDDDDDDD#
@4EW
GTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTN
+
@@@FFFFEHHHGDIHIJJJHIJJJIIGIIIJGHIJIJJJGGHIGIJFHHIIIJJJJHIGHGFHIJJCGBEHEFFFFEFFDEEEDEEDDDDDDCDDDDCCD#
@4EX
GGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGN
+
B@@FFFFFHHHFHIJJHJJJJJIJJJJJJIJJJJJIJJJJIJJJIIJJIGIJIJJIGIGHGIGGHIGGEHGHFFFFFFEDDEEDDCDDDDDDDD5=B5?B#
@4EY
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
@<7B?DEDBHBBFEFHGHEEDGGI@FDH9EFA6?DGBBHI@FFGFGH>FFHGGIII@GHHHHHHFFFCCCECEDDDD'8=9@CDCCCDDBBBCACDDDDC#
@4EZ
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
CCCFFFFFHHHHFIJJJIJGIJJJJJJJGHIJJJJJJJGJJJJIJJIIJIIGIJJIIJJGHBHHFFFEEEEEEDDDD3;B@CDDDCDDDDDDDDDDDDDC#
@4F0
GTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJHHFFFFFFEEDDBDDDDDDDDDDDDDDDEEDDDDDDD#
@4F1
CACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGGGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTN
+
@@@DDAD>C4AFDD:CFFH@D<3<CA<FAF?9C<9F@E<<<?DF?B?DFBFD7B)??>?F8CF/8CBFA7@FGA474@CC=>)7AAC>B>)).;;;3(..#
@4F2
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
@@@DDDDDFHHHHJJJIIIIIJIJJGIJIIIJJJJGIIJEHIIJJJGGHIFGIEFGIJGGIHIAECHHFFEEFC?;;>CDDDDAC@ACCDDD5<BDBCDC#
@4F3
GCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTN
+
CCCFFFFFHHHHHHIJJJJHIIJJJJJJJJJJJJJJJIJJGJJJJJJJJIJJHHJJJJIJJJJJJHIGJJJJJJJGIJHHGHHFFFFEDEEEEDEDDDFE#
@4F4
GTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTN
+
CBCFFDDFHADHHHIIJJJIFHIIJGHHIJJJIJJJJJIJJJFHIJJIJJJIIDHIJJJHHHFFFFFEECFEEEEDDDDDDDDDEDDDEEDDDDDDDDDD#
@4F5
CCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTN
+
CCCFFFFFHHHHHIJJJHHJJJJIJJJIJJJJJFHIJJJJJJJJJJJJJJJIJJHDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDACDACCCC#
@4F6
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
@@@FFFDDHGHBHGEGGGIIJIGGEHIIGBH:DFB:BGG@DD/8DFHIIEFGEGGCDGIGGFHH9BEFEDEDCEDCDCDCCBDDDDDDDDDDD@CDACDD#
@4F7
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CCCFFFDDHHHHGGGIIJIJBBHGHIGHJIFJJGGHIJJIIIGHHIGIGEGDGHIIJHIJIJGIGH=CEHCHEF;BAC@CCDDDD?BCCC>ACDDDDDDD#
@4F8
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATN
+
CCCFFFFFHHHHHJJJJJJJFHIJIHIJJHIIJJIJJIJJJJJIIJJJJJJJJJIJJJIIGHHGHFFFFFDDEEDDACDDDDDDDCDDCDDD:ACCDDDC#
@4F9
CCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACA
+
@CCFFFDFDFFDFHHGGHGEJHHEHGHIAFGEEEFGGIIHIHJIGIJGHDEGGBGHGACFBGGIIIGGCDHH@GIIJHEHEHHFEBDFFCCEECAACDD
@4FA
CTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCN
+
CCCFFFFFHHHHHJJJHIIJJJFHHJJIJJJJJJIIJJJJJJJJJJJJIIJIIJJJIJJIJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFFEEEDDEEDD#
@4FB
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCN
+
@@<?:BD?FBBFHBHD;<F=ACFD<FBHCFGHIHIEA0@DGHGGEFC=CGIE;@EAAADE@;;=@@;CCCCCACC>AC@ACCA:C::A@@>>>>:>@>A>#
@4FC
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@?@FADDFGHGFFGICFGIEHIIJ9CEGH?GGGGGD@BHGB?CG@FHICGGEIIGGIGCGHFEEEFDDF@A>ACAACCDEDECDDDDCDAACCCCC@A
@4FD
CTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTN
+
@@@FFFFFHGHGHIJJIIGDEHGJIGGEFGIIJJJJIIICFHIGIGGFHIGGIJJJJJCEHIIIJJIIIJIIGIHGFEHFFFDDDCECCC>CEDDDDDAC#
@4FE
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGCGTGGGCTGGGCGGTGN
+
@@?BD+AA?=C>4A;?FD9FHEIIB;8<EE1C9??1:C>*1:1:B9BD9B@>GEFB84B:=:<BF85A'77.7).=@@D3.;B:(,38;/5?6;8?55)&#
@4FF
GTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTN
+
CBBFFFFFHHHHHJJJJJHIJIJHGHIJJJJJJJJJHIJDGHIJJJIIJJJJIJJJJJJJEHHCHEFFFFFCCCCCCCEDDDDDDDDDBDDDDDDCDDDD#
@4FG
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
?1=DDBDDDDD<CEEEEE<CEECDDEI@DIIDDIBDDDDA=BCDDEECCC@;=CDD@DD@AAD@AAAABDAAAAAAAAAAAADAAAAAAA><>>???AA
@4FH
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
@CCFDDDDFHAFFHIIGGGFHG@?FDEEIIIIEEHGGEGBGEDFDFGIIBFCEHEFE@FHG@@=CDA>CE(7;>>BCEEEECCC?@@'8<B0@CC@:A4>#
@4FI
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJIJJJHHHJJIJJJJJJJIJIIIJJIJJJJJJJJHHHHFFFFFFEEDDDDDD@CCDDDDDEDEDDDDCCDDDCC#
@4FJ
CGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATC
+
@CCFFFFFHHFHHJJJJJJJJJIJJJJJIJIJJJIIGIJJIIIJJJJJJHHIIJFIJIJJIIJJJJJJJIIJHHHHGFFFDEEEEDDDDDDEEDDDEED
@4FK
ATCTCCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACN
+
+=?DFFFFHHHHFHHIJJJHGHIJJJHIJDHIIJJJJJJIJGIJIJJJIFDIJIIJJJJGHEHHFFFFEEEEECBDDDDDDDDDDDBD<B@DDCDDBB8A#
@4FL
CCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTN
+
CCCFFFFFHGFHHEFGGIGHJIJJJIJGGIIJJIIFFFHIIGJIJGHJIIJJIJJIIIJIJJIGIJGIJJJJIJJJGIJJHHHHHHGFFFFFCEE>CCCD#
@4FM
GTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGAGAAGTTCGGATCTGATATGTTTGC
+
:?;B=DB=C:D:D???4A:AFABH<<A?9F?;C)CGDGI@GI>BBG8DG09?@?B@=CBFFIF@)=7C=)@EA7(6(6;B>B;@B?BBB@(:;5,5;AB
@4FN
GGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTC
+
CCCFFFDDFFDFHHIGCEFDDAHGICBAHEDHIGIII?F?GFHHHCHIHG?DGEHGGIIEECDHE7AEFEB?A;>CACDD??@CDDCDB2?BAAC<AAC
@4FO
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
@@@DDFDFHHHFHIIABGHHIIJFGHHJGHIJJIBGGHJDFGIJIGIIIIJJIGIJ@BHHFHHHFFF@CECEEEDDDDDDDDD>BCDEDDDCCDCDDDC
@4FP
CCCCCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
@@@DDADDBCF<C?FFGGHGHHI?FGHGGDGBFHIIIIGICH?D9?<B<B?CFEGH=@FHIII;DAGEHF=CHEBBD>;A>CC@AA@ACDEECCCCCCC
@4FQ
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@CBDFFFFHHHHGJIIJEHIFHIJJJJJJJJJIJJHIIJJJJJJJJJJJJIJJJJJJJJIIJJJJJJIHHHFDDCDDDDDDDDACCDDDEEDDDD@CDD
@4FR
GCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGN
+
BCCFDFFFHHHHHIIJJJJJJJJJJJFHIJIJJJHIJJJJIJJJJJDGIGIIJJJIHHHHHHFFFDDDDDDDDBBBDDDDDDDDDDDDDDDDDDDEECDD#
@4FS
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BBCFFFFFHHHHHIJJJJHHJJJJJJJJJDHIJJJJJJJJJJJJJJJJJJJJJHHHHEHFFFFFEEEEDEDDDDDDDDDDDDEDDCDDDCDDDDDDDDD
@4FT
CTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTN
+
B@?DFDDEHFHGGIIJJIIIJJJJJJJEHIIJJJIJIIJJIJJIJJJJJJJJJIIGJJJJJJFIIGHIHHHFDFFEACCDECDCDDDDDDDDDDFDDDDD#
@4FU
ATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
???DDDFFDCD>AEGBHGFH<CE<CDACF?CED?CGGGHGECGHCHABDHBDDHGHFGF4=AAC>@;=ACAB>CCC??ACCCBB@5<9>A>CCBA@CC
@4FV
CCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGN
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJIJIJJJJJJJIJJJJJJJJJJJJHIIHHFFDD;BDDDDCDDDDDDDD<@DDEDDDDDDDDDDDDDDDDDDDDD#
@4FW
GGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTC
+
@<@DDDADF?D:DFGDHIIEHGGEGB@BHIGHCFGIIIGIIIGIHIGCFCFAECEHEA).7==?=@DECCCCCCCACC=CACCCC@CA?<?B8AACA
@4FX
GTCAGGACTCTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACGCTGCCACTGACGGAAGTTCTCATAAACGTCCTTGGAAATTTTGGAGCGGTCACCTN
+
CCCFFFFFHHHHHJJJJJJHIIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJHHFFFDEEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@4FY
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATN
+
@@@FFDDFHHGHFGIIJGEGGAHHHGIFIJIJJG?FGIIIJIGGGGEHIJJIIHIEIIJGIGIGIIGHHH7=>>AD3=@CCCCDCCDD:AC>@B5@ACDD#
@4FZ
GGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTN
+
@@@DDDDFHGFAHHEGIICACFGHHIIGGGIIJJIJJIGIJEGGGGGEGIJJGHJGIIEHICFGICAHD>EDFDCEBB?CACCDDDDDDDDBCCC>CDDD#
@4G0
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCN
+
CBBFFFFFFHHGHJJJJJJJJJHJJJJJJIIGIJJJJJIJJJJJIIJJJIJJJJJJJJJJJJJJJJHHHHHFFFFDDDEDDDDDDDEDDDDEDCDEDDDD#
@4G1
GGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACN
+
@@@ADDBDACFHDGGBGGCEFFG9FA+C>@CGI9:CAFGD>BGGG@DGG>B<DHG@FEGBEHE>A7?C7.;AC:;CC??BBBCCCC;@CACCBB?A>:C:#
@4G2
GCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCN
+
@@@DDD>BD;A<?CFDCABHF?EH:3:CE99FH?EHG>@?HFC@>CHGGHC=C@DFHIEB8DBC.==CFEHD;@G@DAH.7?;B7@/;=C:?CACCCCCC#
@4G3
CCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTN
+
?@@D?ADD@CDHHGI@?GFHH?HC?CEFEFFGGGIGGGB=B@B???FFHGIII>-5=D@>BE@>AA?B@CA>CC@>:>@C@?BBB3@<:4?C@>C4>44:#
@4G4
GTGGGATTGTAACAACCAGAAATATTCCAACTATAATAGTAAGTATGAAACTTGTTTCTGGTATCCAAAAATCATCTTTCGGTGGAGCGTCAGTGGGCTTN
+
@=@FDFFBHFFHBGGIGIIIIIIIIIIIIIIIIIHIIGHFHIIFHFIIIIGEGIBFGGEEGDFGGAGGIIIGGEGHIIFGFFEFFDDEDBDBDDDDDDDD#
@4G5
CCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCN
+
CCCFFFFFHHHHGJJJJJJJJJJJJJJJJJJIIIIJIJJJJJJJJJHIJJJHIIJJJJJJJJJJJJJJJJJIJJJJJHHHHGGHFFFFFFFDEEEECDDD#
@4G6
GGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATN
+
C@CFFFDFHHHGGIJFGIJJIIEEHIHHIJJIJJIJIJJIGJIIGIJGIIIIIEHEIJFIGECGGIFHHGHFF@C?AEDCECEDDCD5;ACCCDCCDDCC#
@4G7
AGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTN
+
@CCFDDFFHD>FFFEHEHEGIIAHGIGGFGGGG@FGGEDHGIGGEHGFDHIGBGFHIIEAEECC@EDHEHEHCE=EHBFCDC;>;;@CC@<9>@::>C3A#
@4G8
CCCCCTGTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
CCCFFFFFHHHHHIJIIJJJIHHIJJJJJIJJJJJJJJJJJJJIIIIIIJIEIHHHHHFFDDDDDDDDDCDDDDDDDDDDDDADCDDDDDDDDDCDCDCD#
@4G9
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCN
+
@CCFFFFFHHHHHIJJIJIIIIIIJJJIIIIJDHIJIIHIIGHIJJJJJJJIJ=CEHIIGHGHHHFFFEFFDDDDBDDDEDDDACDDEEDCDDDDCDDDD#
@4GA
CCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCN
+
@@?DAAADAD<CDE>E>2CBCDHID<H?FCACEHABEFCE?F;CFBGGGFFAGGEGGGF?BGCBHIHAACGC@4=C=7.@@EHC3=A@C7;@CCB??CCC#
@4GB
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
CCCFFFFFGHFHHJJIIIJJGHGIIJJJHIGGHIIGIIIHIIIJJIJGICHGJGGHGIJJJIIJIJFFHFBEFFFDCEECCEDDDDD;?BDDDDCED@:@#
@4GC
CTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATG
+
C@CFFFFFHDHHGIJIJECEHIIFHGGIIIGCHIGHIJJIJJIJGGIJIIBFHIIIIGIJGIBFBGEGIIIGIIJFEHHEEHF@CDDFEEA@DC;@CA@
@4GD
GGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCN
+
???BBDDDHF):DGHDCFGIID@FHGIEHIIIIIEG@DHIBCFF==CE?AD?E3??>?@C<<3>?CCC>>5>((5@=>9@BACCCC@CC::8@C@C>AB@#
@4GE
TGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATN
+
@@@DD?@DHBFDHIEAEHHIIIGFH@CHDBH@HEIEEGIIIIFIEIIIIGIHEHIIIIIIGA==3@DA>AAEHEDEDDC@CDCDC5>ABBCB@BCCA@CC#
@4GF
CTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCN
+
???BDB?2A:?ADEDEBDFI<@@8@F@E;??:0?0?BD9?9D?(B6@CB;CEI;6@@:577.,.79';9=5,>>5<A9(:A:A+4++<A?:+(:A:4<2+#
@4GG
ATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGAGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGA
+
;;?AD;=DC:<DC@GEF>H9F?A33<CF:FCDC9DBB9*?DDG88DB4BDAFI<7(;;((;)=7)7???=D3;;>:@AAAB3;5?:A@A<<((,(8(9
@4GH
CCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCN
+
CCCFFFDEHHHGHJJJJJGIJJJJJJIJJJJJJJJJJIJIJHIJJIIIJJJJJJJ=FHI@EHHHHHHHFFFFFFDDDDDDD;@BDDCDDDDDDDDDDDDB#
@4GI
CCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTN
+
C@CFFFFFHHHHFGFFHBHGEAGFFCF?GDHGGGGHEGDHGEHHCHGIBDCGEHHBAGGGGGIIGHGH=7;;;?B?ACD?ABBB?B@BDDBDDCCDDC?B#
@4GJ
CTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAA
+
CCCFFFFFHHHHHIJJJJJJJJJIJJJJJJJJJJJJJJJJFHJJJJHHFFFFEEEEDDDDDDDDDDDDDDDEEDDDDDDDDDDDDEDDDDDCDDDDD
@4GK
ATGCACTTCTCTTGCCCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGCGGCGCCCCCAGCCCCCTGAAGCCCAGGTGAGGGCCGAAGCCGCCCATCCN
+
@B@FFFFFHHHHHIJJJJGIHJJJJJJJJJJJJJJIJJJJJJJIJIJJJJJJJGHFFDDDDDDDDDDDDDDCDDDDDD@CCBDDDDDDD9@D>BBDDDDD#
@4GL
GGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGT
+
BCBFFFFFHGHHHJJJIJJGHIJJJIJIJJIJJGIJJJGHJJJIICIJIJIHJJJJJJJJJJJJIJIIIJJJJHHHHHHFDCE>BACC@CEDACDDCDE
@4GM
CTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIIJJJJJJJJIIJJIJJJIGIIJIJHHHHHHFEFFFFEEE
@4GN
GTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGC
+
CCCFFDFFHHHGHIHHIIIJIGHGJJJJEFCHHIIIIJGIGGFHIJGEIJFHIGJ@FHIADEHJGEEHEHBCFFFECDCCCBDCDCDCACBB?ACA@C
@4GO
TTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJJJJJJJHHHHHHFFFFED@CEEDEDDDDDDDDDDDD
@4GP
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
CCCFFFFFHHHHHJJJJJJJIIIJJJJJJJIJJJJJJJJJJJJJJJIIJJIIJHHFHHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDBDDDDDDD#
@4GQ
ATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTN
+
CC@FFFFFHHHHGJJJJJJIJJEHJJJJJJIHFHIJJIIDHIJGIJJJJJ@GIJFIHHHFFFFEEDEEDDDDDDDDDDDDDDDDDDDDDDEDDDDDDCDD#
@4GR
AGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGN
+
@@@DFDDFGGHFHGIIIIIG?CFHIIIIIIIGEHGHIGHII=BGHECHI?EEHFHHFFFFFEDCACDDDDDDDDCCACDDBCCD<<BAB?ACBC>CCADC#
@4GS
CCTGGCAATGCAGATGCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGN
+
C@CFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJIJJJIIIIIJJJJJJJIJJJIIJJIJHGHHFFFDDCDDDDDDDBDDDCDDDDDDDEEDDDDDDD#
@4GT
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTAT
+
@CCFFFFDDDBBBDDDDCDDCDEEEDDDDCCDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDD<BDDDDDDDDDD:AC@CD@CCCCDDCCCDDDDD?CC
@4GU
TGAGAATTCGGCATTTAACTAGTGGCACTACAGGATTCCTATACAACATGCCCGTTGGTCCCCTCCCAGGTGATACAGCGGGCGTTGGCGCTGTCGG
+
???D;4B,2ADDDAEIB4<C4:AABEB<3C>*?D39?9**?49?DE9893BD;''(-6-.@;;CA=A3;7).)6;;>(;'38&5&)58>59595:<5
@4GV
CTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGN
+
@CCFDDFDFHGHGIJIGIGIIHGGGGIIIIIGHIIIEHGHGHHIIGHGIIIICGHIGHIJJIGEGIJJIIIJJJJICGGIIJFEEEHDEFDEFFCECEED#
@4GW
CCGGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJFHIIIJJIIJJJJJJHHHHHHFFFFFFEDDDDDDDDDDDDCDDDDDDDDDDDEEEEDDDDDD
@4GX
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFEEEEEEDDDDD;@DDDDDDDDDDDDDDDDDDDD#
@4GY
CCGTGTTTGAGAGTTGGAACCATGGCTGCTTTCCATAGGTGAAGATCTCCCAGAGGATCACCCCGAAGCTCCATACATCACTCTCTGTAGTGAACTTCCGN
+
??@ABDEFDBDDHAFGGGHIIGGHIIGGCGGIIIIIIIIFGGGGIGCGGIEIIEIG@GIGEHGIHEHDFB@CEE@CCECCCCCCCCCCDCDCEDCCCCAB#
@4GZ
GTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCN
+
@@CFFDFFFHFFFIGFGHEIHGGJJEHIIBFGFFHIGEGHFHHIJGIHGIJ@FBDHH@DGGIIGGHIJACBFGABGCHEHAFFDGD@=@7=?=CEHFCFF#
@4H0
GCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGATGGGGGAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCC
+
:8?DBA=DC2=ADGIIE;F<CFGG@1CBF9DFIFC@D/<B555022<55(&+++2&))&+(:::3;0))09>B9&)08@B@B3(:(+(++:(:&)5&)(
@4H1
TGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCGGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATN
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJJJGG@FHIJIJJIJIJJJJJIHHHHHHFFFFFFFEEEDEDDDDDDDDDDEFEDDDDDDDDDDDDDDDDDDD#
@4H2
CTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCN
+
?@@DB;:D;CCFFBBGH<EAE>F@AHGC<EFEHHECGAEFF<@FDFHBBHI<B8BFGGHEGI>C@DHHF<?DEB;A>AC5-;?CCACCC595::@CCECC#
@4H3
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTN
+
@CCFFFFFGHHHHEHIIGGIIEFEHGGHIFHIIIJIGEDHGDDHIGIIHIBF@GAHEGHJJGHEEHHHCDEFFFEE>ACBCCCDDCCB@C5>C>@CCCC>#
@4H4
TGCACATTATCCACGGATGGCCTTGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCN
+
CCCFFFFFHHHHHJIIIGHGGIIJJIFIDGHHIJGGIGIJIJIIEIJGIHGEGIIJIFGHIJJIJJIHFFHGHHFFFFDCDDD9AAB?AADCDDDDCCDE#
@4H5
CTCCGCAAACAGGAGGAGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTC
+
@@@DDDDDFF>FFE=G+<ABFGFFI:8:DGFE;FGEFE?FA;@@F@C7@A==<@>>@BBB?>>AA@A@@??A@A@AA:>:??<9@BBBBBB@44>3@D:
@4H6
CTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTGGGTGGTCN
+
@<?DDDDDAFBFHBGGG::3A@CCC<F>?G=FEGHIGHI9DBDH<<DBGGBFCFDGEGGHIEF:CC.@@@C>EE77?ACEEDCEC@@AA6=5@AB??B8@#
@4H7
GGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
CCCFFFFFHHHFHJJIJBHIJJJIJJJJJGIIDFG@GIIIJJJJJJJJJJFGHIJJJJJJJIHHGHFFFFDEDDCDBDEEDDDDDDDDDDDDDDDDDDC
@4H8
GCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTG
+
@@CFFFDFHGGHHIJJJJJIIFHGIEHHIJIHIGGIBGHIJDHIIJJJJIIJIDGHGEGIGJGGIGIGIGIEHGEHGGFHCEHH@BDEFCCCEEACDDE
@4H9
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
@@@DBDDDDBFADFEGGH??GH<?GFE?DBDFAFHEBHHEEHICCHGDHEGHGEACACHEDEEE@CCCCCCCC@CCADCCA@CCCC?<<>B@AC>AC>@:#
@4HA
CCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCGTAAACACCCATGCTACTGGGGTGGTCCN
+
CCCFFFFDHHHFAHGIBCGGE=FGIIGCDHGIIGGHHIICHFBG@7CCABGHGDDEB?CCECECCCCCCCC<2=:?BCCBB@B9<?>CCCCCBB05@0@A#
@4HB
CCCCACTTTGCGGCTCTCGCGGAGGAAGCCCCGCAGGGAGCCGTATTTGGCGTACTCCACGATGAGGAGGAGCGGGCCATCCTGGCTGCAGGCCCCATACN
+
@@@DDDDDHH??FGGIGGG7?DGGAECFGGCGEHA?E>ACBBBBBBCEECCBBBBBCCCCB;A@C@CA@BB?B39@<@BCCB<@C?C<@CCBBBBBBCCC#
@4HC
CTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGC
+
CCCFFFFFC=ADFHIJJJJJJJJJJJJJJJJJJHJJJJJIJJJJJJJIJJJIJJJJJJJIJJJJJJJJIJGHHHHHFFFFFDCCCECCDDDACCA>CDD
@4HD
GGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
CCCFFFFFGHHHHGIIJJJJJJJJJGJJJJJIJJIJJJJIIJJJIIIIJIIJJCGIHHHHHHFFF;ACEECEEDDDDDDDDDDDDDDDDDDEDDDDDDD
@4HE
CCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIJJJJJIJJJJJJJJJJJJJJJJJJJIJJJIJJJJHHHHHHFFFFFFFEEEDEED
@4HF
GTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTN
+
????;ADDDDHDDGIIGBEEEFBGH@F?ED8?FBDD@DF@D*::?<?FBGHEHHADHIG=@;@FAACHA=>DH>HBEDFFCBDE6;@>;;@D>;@>;@;C#
@4HG
CTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCN
+
@CCFFFFFHFHHHJIFGGGGGIIIGIGIGGIJJIIGHHIGIEEHGFFGHHGHIGHJIHGEIJHEEEEEFFFDFFEEED>CCDC>:AC>ADC@:ACD@CCC#
@4HH
GCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATN
+
CCCFFFFFGHHGHJJJJJIJIIJIJJJJJJJJIJJJGGFGIIIJIJJJIIIIJIGJJJJJJJJIEHGHHHHFF;ADBBD>BCDDDCCDDDDCCD>?B5@C#
@4HI
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJIJJJJJJJJJJJJJ@EFFAEEDEEDCCDDDDDDDDDDDDDDDDDDDDDDDD#
@4HJ
AACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAA
+
?@@BADDDHHA@DGEBGIBC@@DFCGGEBDC>?D?BBGBHGGEHAC@GFFCHAAGHEFE@DCD@@B>>A;;>@5@>>;=53;;9=CCCCBBCCC@@CAC
@4HK
ATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTN
+
B@BFFFDFHHDGHJIIJJIJIJIJJJJJIJIIGHIIIIIIJHIIDFHIIIIHGGHHBFGIIIJJJJII@DHF5=DFEFECEECCDDDDCB<>>BDDDD09#
@4HL
CTCAGTGACTGGAGATGGCTGAATGTTGGCTGCCAAATAGAAATGTCCGTGTCCTAATCCCCAGAACGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTN
+
CCCFFFFFHHHHHJIJJJJJJJJJJIJJJJJJJJJJJIIJJJJJJIJJJJJJJJJJJJIJJJJJJJJJHHHF;BCDDDDDDDDDDDDDDDDDDDDDECDD#
@4HM
GGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATN
+
CCCFFFDFHHHHHJIJJJJIGIJJJJEHJJJJJJJJIJJIIJJJJIJJJJJJJJJIJIJJJIIGIJHHHGHFD@CCCCEEEDEDBDDCCDCEDDCDDDDE#
@4HN
GCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGN
+
CCCFFFDFHHHHHJJJJJJIIJJJJJEGHJJJJJJJJIIJJJIJJJJJJJJJHHHHHFFFFFEEEEEEDDDDDDDDDEDDDDDDDCDDDDEDDDDDDDCD#
@4HO
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
B@@FFFFFHHHHHJJJJJCGHJGHIIJJJHHJJJJIJJJJJJJJJIJJIIJJJHHHHGHFFFFFEEEEEEDDDDDDDDDDDDFDDDDDDDDDDDBDDDD
@4HP
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCN
+
@@@ADFFFFFGHHEBFIIIF@AEHGHHBHHIFDHGHIF?GDHACFGDGHFDGHHHHGFFCGEH>@7=FCDE@GEEHHF>@D@C>AAA?>?BBBB:?BBCC#
@4HQ
GCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCN
+
@@@DDDDDHCBBFGIFBGDHCHGEGHIIGH:CDDDEGHHIIICEHE<DDHIIGHEGD8CHCHEHII):?9?C=;>CCC>@A;ACC>C5?B8>ACCCCC@@#
@4HR
GGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAG
+
BCCFFFFFHHGHHJJIIJJIIJJJJJFHIJJJJIJJIJJJIJJJIJHIJJJJIJIJIHHGHHFFD>?>CDDDDDCDEEDDDDDDDDDDDCDDDDDDDD
@4HS
CTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGG
+
@@@FDDFEHGHHHIIIEEGCHHIHHIGIII9AFGEHBEFFHCHBDGGGHABHGIHIIEHGEHGG@GGIGGGCCEHGGIGIEGIECEHEDFDFEFCEDEE
@4HT
GTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
=:?;:BADBDA;FGHI@C?HHGIIIIIGGGHFEDFGEIHBDHIG4BGIIIIH@@AEECHHGHFGGGG@DEEHHEED@BDEEECCCCCCB@A?CCB?>CC
@4HU
CTTCACATTAGATGCTGTCACAAATGGAGGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTCGAATTGAGGGCAGTCTGAGTAAGGAT
+
?;??DDA;F<D<,<<E?G>:<3<F43<+CG+:9?BB8:B:)0?GBB?G>889D<BBD(;(.)7;4=6=98@,,3585<A::?B>B3<>:A4>4>AAB:(
@4HV
GTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCC
+
??@D:ADEHHA:ACFGIIIHIADBCHIIIIIIIIIIGIIICDDHGIGFGGEH8CEDHHHGEEHCDFFFCEECEEDEDC@@CCCECCCC:CB?<BBBCCC
@4HW
AGCAGGACGGCATCACAGCAGCCCCTGCTGCCTGAAATCAGAGCGGCCCAACGAGGAAGGCCAGGAGGGTCGGCTGGCAGGGGGCAGGGTCTTGGGATA
+
??@D?:BA@FDDFHHIGGEHDGGGBHDA@?@>DHGC>FHIGHDBFIB:BBE(=;>3>?BBB92<?A85&(395-(5@B<<<BB999>>>CC<@>>A<:?
@4HX
GTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCN
+
@@@BDDFFGHHHHJIIIJJJJHIGGJIJIGGIIJGIIIGIIIGHIGIIGHGGHHIGHEHHIEGIJIIGGHGEHGGIGGEHIJHCCHEHBEFDCBACCCDD#
@4HY
GGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTN
+
@?@?D=DDA:D?<<EA:1<<?CC??FBDGBDDG@?9DB;D??DFBB87@8;:A;776;;=6;;;=59@;<A::><(+244++4?89:+50<>&9?382<:#
@4HZ
AGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCN
+
@@@DBBDFBFHHBHIGIGCGEEGC@FGBHEGGCHIE@AGEE?DBEEA@CAC@C=CDDA@C?C@BB7B@BB@@BDC?CDA<CC>>ACCC?BDBBBBBDDDD#
@4I0
AAATAAAACAGTTAATGGGGACAGTCGAAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAACAAGAAACN
+
?@@D?DB=D;<2AFHI@<FH;<ACC?FB;E??9C?:0?F*:??FHDH49??B?@<..86(=@.==5?65'7;;@;>A666(;6(3?@B:A@:5995<9?3#
@4I1
GGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTN
+
CCCFFFFFHHBFHIGIJJJJJJJJJJIJJJJIJJGIIGJJJJJIEIJGHIIIIIIIJJIJJJJJCHHHHFEFFEEEDEECDD@BDBDDDDDDDDDDDCCD#
@4I2
CCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGN
+
CCCFFFFFGHHHHIFGBCH@FHHAHIIIAFCHIIIIFGHIBFHGFGF@FHE@CAHFHCHHFFFFEEEEE:ACEDCC:AC95>@DCB?C:ACDCDDDDCED#
@4I3
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATN
+
CCCFFFFFHHGHHJJIJJJIGJJJJHIJJHIIJJGIJJJJJJJJJJJIJIJJJEHIIIJJJHHGHFFFFFDDCEDDACCDDCCDEDECDDCDCDDCDDDD#
@4I4
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
CCCFFDEFHHHHHJJJJJJJIJJJJIJJJJJJJJJIIJJJJJJJJJJIIJJJJJJJJJJJJJJJJFHIIIHHFHHGFFFFFFFEEEEEDDDDDDDDDD@B#
@4I5
CTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACN
+
@@CFDDFFHHHGHJJJJJJIJIJJJEIJJJJJJJDHHIJIJJJEIJJJJJJIIJJIJIJJIJJGIJJHGHHHHHFFFFFFEEEDDDDDDDDDCCDEEDDD#
@4I6
GGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJHIIJJJJIJJJJHJIJJJHIJHHHHHHFFFFDDCCEEDDDDDDDDDCCDCDDDDDDDDDEDDDCDDD#
@4I7
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCA
+
??=B;DDDFFF>BB<<EFFB@GIIIF@7EF@EFE;DA<GAFDAFI;BFCCFFFI4=CFIID=>B?@CCCB@AABB@'8?@BBBBABBA?A@?BBB<B>@
@4I8
GAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCN
+
@@@FDFFFGFFGHABGHBEDE2AEHFEHIHIIGGHIIGHIIIIIIGHGIIIIIGHGIIFIHGHHFCEFFFEECCBBCCCCCCF>>CDCCCCCCCCCECCC#
@4I9
TGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
CCCFFFFFHHHGHJJJJJHIIJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJIIIJIJJHHEHHHHHFFFFFEEEECEDDCCDD8ABDDDDDCDD?BD#
@4IA
CTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGN
+
@CCFFFFFHHHHHJAFGIJJJJJJJJJJJJJJJJJIJJJJJJIIJJJIJJJJIGJJJJJJIDGIIHHHHHHHFFFFFEECEDEDDDCDCDD@CCDCDDDD#
@4IB
AGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTN
+
C@CFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJIJJJJJJJJJJJIJJIJJJJJJJJHHHHHHFFFFFFEEDEDDDDDDDDEEDDD#
@4IC
GGGATCACCCCGAAGCTCCATACATCACTCTCTGTAGTGAACTTCCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGGGTGGCCTCN
+
??<DD7DBBB<D:EEDB>@@E>@*?E**1C*:?40??*90BDB?<?D0-<8=)8@;@).77=7=3.-9=;(>6((>;?=':A??8002448(+)5&2<>>#
@4ID
CAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTN
+
@@@DDDDFHHHGFIJJJIJJJJJIJJJJIJJJJJIJJJCHIJJJJJJJGIJIJGJJJJJJJJJJIJCEGIGHIJJJIJJJHHHHGHFFFFFFDAEDDCDD#
@4IE
TGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACN
+
CCCFFFFFHHHHHJIIIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJHHHHHFFFFFEEEDEDDDDDD>CDDDDDDEEDD#
@4IF
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJHJJJJIJJJHHIJJHIJJJJJJJJIJJJJJJJJIJJJJHHHHFFFFFFEEDDDDDDCCDDDDDDEDEDDDDDDDDDDD#
@4IG
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
CC@FFFADBFFHFIIIIHIIIHIGGH9:BGGAFDEGGCEH@FHIHHHIEHIDHH>>?BCFCCCCCCCACCCCACBCCC@3>ABCACCCCC?BBBCCCCCC#
@4IH
GTTCAGGATCAGAGGGTGCATGATGGGTCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACN
+
@@@DDD>BDA?C<BC@<?;<CCCE?FEAC@DFBBGIIIIHIIEBBBBBF;FGB-===CA?C??BB<<<;559>;8@CBC?A?>BB+99918<9<<<>B<?#
@4II
CCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJHHHHHFHFFFFFFEEEEEDDDEEDE#
@4IJ
GAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJIJHIJJJJJJJJHIJIGIIJIHHHGHFFF8>BDBCDDEDDDDDDBDDDDDD#
@4IK
CCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGN
+
???AD::DDD7DDDE;E?33<FEFECEB:D::&788>A3<(3>8>BDEAAA=AAA=877<<8=A:4>:3:>>A>>3:>A>AA<>?;?03:>?A93+::>3#
@4IL
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
@@@ADDDD;C=DDBFGB9FGHEHFHIIIICGICGII>FGGC>F@FGI>BFG8C>FGIIIACD>?EE@EEEE?CCC<CBB?CDCCCCCB@BBBBCCCCC@
@4IM
CTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGG
+
@@;DDD?DBCFFDHGAFEGFGBGIICHD?FHD@DCG@GHIEAAFHCHG;FHHGGIIHECBBBBBBCA34>CCCCCDCCB@BB@CCCCAC@CCDC@:CCC
@4IN
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@CFADBDFDBFFIGH@GGHHHHCHDCGGGD9DHIECFEFHHGGHIGGHIIGDGGAFFFHCCHHFFHEEDFEFFCEC>@CDACBD??BBAACD>AB28@
@4IO
CGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTN
+
BCCFFFFFHHHHHJJJJJJHIJHIIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJHHHHHFFFFDEEEDDDDDDDDDDDDDDDDDD#
@4IP
CGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTG
+
CCCFFFFDHHAHHGEHICFEGIGGGJJIDGGAFHGGJCHHIIGIF@FHGHIJJIEDGEHIIJJFHGECEHDFBACACD@CDDDDDB@B5>:@CCDC>C
@4IQ
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@@FFFFFHDHHGJFGGIGJCFEHIIJJGIJIAFGFHGIJIJJJJJJHJ@GHJIGIIJIJIHIJJJJIFHHFDDDBDDDCDCD@C@>BDCDDDDDDDDD
@4IR
CCCAAATCAGAATTCCAAAAGACCATACATCAGATTGAGTAGTGAAGATTCCATCCATCAAACTTTCTGGAGCCATCCACCGAACTGGGAGCAGGCCTTCN
+
C@CFFFFDHHHGHJJJIJJJJJJGIJJJIJGHGIIIIIIFGIHIIIGIJJJIJJJJGHJJHDIIIIIIGGGIJIGIJHGGHEFDBCEDDDDDDCDDDDDD#
@4IS
CTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGN
+
@@@DDDDDDHAD=FB618FFFGHEH>GD9?<??DGFFCFDD@?DGIGCCBFGI@F@DCC:AEHHFA@CCCEB@A?3>??CCC@CC@C>>:5?BB<@BBCB#
@4IT
GGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTN
+
@@7DDBBBBB@@BBDDDBBBD6@CDDD@6*7ACDA??B?ABDD6:8?CDDC>ABDDACEDA3:@CCDDDB<A>9@<>CDDDBCCCDDDCD(:?BABDD28#
@4IU
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFDFHHHHHJIJJIJJJJJEGIJHIJJDHHJIJJJJIJDHEIIGIJJJJJJJJJIJJHHHBDFFEEEDEEDCCDDDDDDDDDDDDDDDEDEEEDDD#
@4IV
ATGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGG
+
CCCFFFFFHHHHHJJJJJJJJJIIHHJJJJJJJJJJHHIJJJJIJJJJJJJJJJJJJJJJJJJJHHHEHFFFFFEEEEEEDD?CDDCDDD8?BDCDDD
@4IW
CCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTN
+
C@@FFFDEHFHFHJIIJIJJIGHJGIIJIIIIGIJIJJJJIHJHIIIGJJHHFHIIHJGHHGGIJII@GHHEHHF5>ADEEDDDDD8ACDD@CDDDDDDD#
@4IX
ACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@CCFDFFFHHHHHJJJJJJJJJJJJJJJJJJJJHGIJJHIJJGHHIJHIJIJJJJJIJIIIIHHHHHFFFFFEEDDCDDDDCDDDDBBB:@CDDDCDDD
@4IY
CGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCN
+
BCBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@4IZ
TAAACATCTCGGGACAAGCCGAAATCCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCTGCCAAGTCCCGATGAACGAGCTTCATCTN
+
@@<DDDDDHBFFAGFEBHFG?F@@GEEHACACFGGADHGGGH@A;;ABE<>AEEE>??;?A@>CCD35>CC???ACC(,5>@B7<5:@:A9>><:>>A>C#
@4J0
CTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTN
+
???DDFFDA?ABFGGGBCC@BGCFHGHIGGGH:DGE8DAFHIIB;4?>DBCEB76;=>?:;=:<3,23>CCCACCCC@ACCC::>CC@CA:>@CD>:>:>#
@4J1
CATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCN
+
CCCFFFFFHHGGHIIIHIJJFGIHHGIJIJJJJEGGIJGGHIJIJIIIHIJJIJHIIIIJAGHIIHHHHFFFFFEEECEEDD@@=CDCCDD@CCDDACDD#
@4J2
CTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTG
+
@@CFDDBDHHHHHGIEGGIIIIIIIGICHIGGJJJIGGDDE?DGIGGBGGIGHIF@E@DE8?=<ABCAD@BCBDDD@BDCDDCCDDDABCBDDDDDCCD
@4J3
CAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGG
+
1=?=:BDD8?DDAEEG3:AE9E8C:F6D0B;DFF4BD3?B?<@@4=9==7A7;D=A=CCD3;?;;AAB>B@B;;5::;>;>A3:?/+9++>>(:@DABB
@4J4
GTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTN
+
@@<D?BB834,:CFEFGGCI7IF,<A3<+<9+<BEG4CCFCDGA**9**800?FF'5@'7@;C>7=@B@;;6@>@B:>AAB(58<?B@A@BABDD:+:(:#
@4J5
AGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCN
+
@@CFFFFFGHHHGJJJJJJJIHHIJJJJJJJJJJJJJJJJJIIJJJJIJJJJJIIJI=FHIJHEHFFFFFFFEEEEEE>@D?CDDEDDDDDDDDDD@CCD#
@4J6
ATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCN
+
@@@F?DFDHDFHHGIIIIIEGIIIIIGHIECF<E:DHG;BFEDGAFACFG@9=CHIGHFHD<4,(.6;>;=@B>?>::+4>8@4>8>?8(4:@3>ACBCB#
@4J7
GAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTN
+
@@@DDDFFGHHHHIJJIJIJIJIIJJFGGHHIJJJJJGEHIJJJIJIIJIJJIHIJJJJJJIGJJIIGHHHHHGFFFFFEDDDDDDDD@@DEDDDDDDDD#
@4J8
CAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATGTGCCTCCTTCAGGAATN
+
??@DDDB?DAFDFBFEHIFFBGHEIE9F>BEHIG;81C9?DFGIIIIIGHICCHIIIHII@FC;@E@DGIHEHHA>BDDDDDA>.>CEEDDCCCCDDD@C#
@4J9
GTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGG
+
@@BFFFFFHHHHHJJJJIJJJAHHHGJJGHIJJJJJJJJJJJGGIJJJJJIJHIJIHIGJJJJJJGGGHHFHHHFF@DFCEEEEEDDDDDDDDDD:>CC
@4JA
TCACCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGN
+
CCCFFFFFFHHHGJIJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJIJJJJJJJJJJJIJHIIJIJJJJIJJJJHHHHHFFFFFFEEFEEEEECDC#
@4JB
GTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGN
+
CCCFFFFFGFFFHJJJJJJJJGIIIFHJJIIIJIIIJGGGIIIIJJIIHJGIIIGGFGGJGGGEIHIHEGIIHJEGIGGIIGHIIJJIGGGEAECEDDBD#
@4JC
CTTCAGGCTTGCCAGAAGGGCAGTAAGCCACTTGTTTTTCTTGGCAGAAATCTTTGTCTGCATGAGGTTCCTTCTCTTCTTTCCTCAGACCACAAGATTCN
+
@@@DADD?DF6B;?EG@GG8;F@AFHF3*C9D>CF?BB?BE*99BD?;D@F9.8=C8/.=4)=;)777=3=A?.;;BCEEAA:6;@(>C>?(;59?(>@(#
@4JD
GCTCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACN
+
@@@FFFFFHHHHGIIJJGGHIIIIGIGGGHGIJHIIJIJGGHIIJJGDHIIIJGIIJJIIGCJIIJIEIEHIJHIIJJIIIGFHHHEEDEDED@ADDDDD#
@4JE
TGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
CCCFFFFDHHHHHJJJJHCGHEIIJJJJJEGGCGHJJIJJIIJHIJJJJJJJJICHHGIGJDH?AAAEHBEFFFCEEE>ACD>CDD,:?B>CCBCDD8AC#
@4JF
CTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGN
+
BBCFDEFFHHHHAGHIJJJJJJJCGHIIGIJIJJJJJJJJJJJJJHHJIJJJJIJJDHIHHHHHFFDEEEEEDEDEEEDDDDDDDDDEDDDEEDDDDDDD#
@4JG
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
@@@DDD:BCFDFDF@>FHB@CFE<CF=GHEF)1:?*?B@?BG7?DAF88)8=B;F@CEIGGECE5=BE3@>=;>(-;;;>@A<85=9>:@@@B:C@:4>@#
@4JH
ATCCAGTTTTGTCTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHIJJFHGHIIJJJJJJJHHHHHFFFFFFEEEDDDDDDDDD
@4JI
CATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTGCTGCCCGTAGCTGCTGCTCN
+
=@@DDD3AD?FHHIIIIIIIIGIHII@GEGG?FGCGHIGGHIIIGHEGGIGIIGHIGGIFGGIGIIIIII>EFEHFE@DEEECCCCCB@BBBACCCCCCC#
@4JJ
CCCCGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCN
+
CCCFFFFFHHHHHJJJJJJJIIJIJJJJJJGHIFIJJJJJGJIJJJJHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEEEDDDDDDCDDDDDDD#
@4JK
GCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTN
+
CCCFFFFFGGHHHJIJJJIGIJJGIIJJJJJFIIIJJGIJJIIJHGHFFFFFFDEDCDEDDDDDDDDDDDDDDCDDDCCDDDDCCDDDCDCDDDDEDEEE#
@4JL
AGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTN
+
?<8ADDDFHHGFABFGGEAFEHGHGGFGBHCCGGIIIIE>GHADBDBEGIB@59BCCC<;>CE5>>>>ACBDDD@883<<?C@ACCBDCDD:>ACC@CA:#
@4JM
CTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTN
+
@@@DDDADDFHHDGIHI@EEGHE?<AFBG8@7B@FAHDDCHI@HEFGE?E@EFDBB<;;@?CC@?C:>A@>,>>>ADD>B@@>28<<:59@5?CEC@CCC#
@4JN
CTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCCTCCCTTTCTATAGTAGCTCGCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGGCN
+
?@@D?DDAAFHHHJIIIGHIJGEGGIJIJGIJJJJIIIIIIJJJBGAFGGIIGGEGEHHEFCCCEEEEDDDDCDDDDDDCDDDDDDBDDDDDDDDDDDCD#
@4JO
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCN
+
@@@FFFFFHHFDHIIJJIJJJJAHGGDHHGGGIGIJIJJIIIJJFGHJGIIIIHIIGGGGIGCHGGIJ7@AECHFF,>AA>@CDCDD8ACCDDD:ACCDB#
@4JP
AGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTN
+
CCCFFFFFHHHHHJJHIJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJHHHFFFFFFEEEEEDDDEFEDDDDDDDEEDDDDDD#
@4JQ
CTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJGHHIIJJJJIJJJJIJJJJJJJJJHHHHHFFFFEEEEEEEDDDDDDDDDD#
@4JR
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
CCCFFFDFHHHHHJJJJJIJJJJJJJJEGIGHJJJJJJJIIJJJJJJJJJJJJJJJIJJJJJJHHHFFFFDEEEEEDDDDDDDDDDDDDDDDDCCDDEE
@4JS
GTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGG
+
?@@=B3:AD8:AF?:E?:A>@DHBFEH>@>2<E<>10?A?DE??9?BF*99B=F)==F)=@=.7;CDE;7AEC>AEC>@@D@>A669;85;,:3;@@59
@4JT
GTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTN
+
@?@FDFFDFHGHHJIIIJJJIGIIJIJJIIIJIJJJIIICHHIIIJIJJJJJJGCGGGGIIIJIJGGEHHIGEH?AHFFDFFFEACCDEDEEEECCCDAA#
@4JU
GAACCTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTG
+
CCCFFFFDHHHGHJJJJJIIIHIJIJJJJJIIIJJIJJIHIIIHIJIIJJGIIJJIIIJJJHIHHGHHHHFFFFFFEEECCEEEDDDEDECADDDEED
@4JV
ATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGT
+
@CCFDFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJJIIJJGIEGIDHIHIGIJJJJJJJIJJIIJGHIIJJGIGHGIIGIGHGGHGEHHDFDFFDCEED
@4JW
CTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAA
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJIIJJJJJJIJJJJJJJHHHHHFFFFFFFEEEEEEDDDD
@4JX
CTCCATCTCAAAAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACN
+
CCCFFFFFHHHHHJIIJJJJJJJJJJJJJJJJJJJJJJJJIIJJJIJHHHHDDDCCCCDDCDDDCDDEDFCDDCDEEED?BBDCDCCDDDCDDDDDDAAC#
@4JY
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
@@@FFFFFHHHHHJJJJJJJJHIJJJJJJJDHIJJHJJJJJJJJJIJJJJJIJJJJJJJJJHHHHFFFFFEDDEDDDCACDDDDDEDECDDDDDDDCDD
@4JZ
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCT
+
CC@FFFFFHHHHHJIGIIEGIJJJHHIHGEH@BCGIJGEHJJIJJDDDEHIJJIIJDGIGIGIIIGFHB?BC@CCDCCDDDCDDBDDBCCDBD
@4K0
GATATCTTGGAAACCCAGTGTTAGTGCCATCAGCTCTCGTGAGTGGTACAGGACTCTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCN
+
CCCFFFFFGHHGHGHGIIIHIJJIJJJJIJIGJJJJJIIDHII?DGBGGHJIHIIIJJJJJJJJJJIIEHFHEE;>CCCCCDDCDDDDDDD>CCD<ACDC#
@4K1
GTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCT
+
@@@@DDDDDHGHFIFGAHGGGGEHG@GHIGIIEGGHGIIIGBGIIIAAAEH@EHIGHEFC>BDBECCCEC@@CDD@CCDAA>?BDBB8<AACDCD@CD@
@4K2
GTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGN
+
CCCFFFDDHHGGFIIG<CGHHIICHIIGHIECEECFGGCGHIDGIG*?FHIBHHGDHIBCFEHIHIDFH@AGHIHF=:99AA@A@CDDACCDECCCC:@B#
@4K3
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
=?=BDDDDD,=BDEAEFCEH@CFHHIGIIIIGIIIIGIFICGGGGIIEGBAFEEGGGIIIIGIIIBEHHEHECBB@B9@CC>C49>4@:CDCCCB:>CB
@4K4
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCGGCTGCCCAGAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
8?@DD>BD?<B?FE33CE@@C<CC<EF*@:CG?FDBDE7DFC=(;4@4(=?B(6=?=@BB(;>@BAB??8?BB844(+((:>A44@@8>A>A@BB(+(
@4K5
CTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAA
+
@@@BDABDDBDFBG?AF@:?C?C:A<<AABFBHHA+:C9?EBGI@BB9BBBGA?<F??FG@G:/098/).8==@@@F@F@@=C=CE>E===7A>;)7;7
@4K6
CTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
CCCFFFFFFHFHHJIJJJJJJJJJJJJJJJJJHHJJIJJIIHIGIIJJJJIJHIJJBFHIHIIJCEEHHFFFDFD5=CDDCDDDDDDDDDDDDDDDD@
@4K7
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
CCCFFBDFDHHFHIJJJIJJJIJHIJEGIGHIJJJJJJJJJJIJIJJIJJJJJJJIJJFIIJJGHHFFFFEEEEEEDDDDDDDDBDCCDDCD@CDCDEE
@4K8
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCN
+
<<@DDDDA<FAACGE@3C:3?:+C@:<CFEFGBDC??:)9?<BG?*9DFIIE8B@CA=C787;@EE;DC;5A;BDCC@;;B>?5;;>B22;A::4+4++(#
@4K9
CCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATN
+
?;?;DADA4=C?:ACGF@<+3A4?CE>FFBC9;F3CC??DBDBB;D9?DDAF?8B=<3./.@@@;C).@;?;?BD@>1.;;@C>B?BB@AA>BB:@@@@B#
@4KA
CTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGN
+
?@@?BDD?FDDDHIHGGDB@<E=?@DF:3DDEGGGCG><9BFACGC>DF>=C=FB@;A1@D4=)=?C?3..);;99>;@CC55>A5:(>>>CAB8?B:::#
@4KB
CAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCAT
+
CCCFFFFFHHHGHJJJJJJIJJJJJJJJIIJJJIIJJJJJJJHHFFFFFFEDDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDD
@4KC
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCN
+
??@DDFDDDDDFDGGHGAGGCEHHHGGIIIIIIIIIDHDADGGIIIGI?CBGGGIGECHGCHGGGIFHCHGFFFFDFCCDDBB?=@88?<&2>AC::@>C#
@4KD
CTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTN
+
@@@DDD,A:A=A<AF9FEH<I>BC@E?C;;ED??F@GFF4?????:*:DB44B>F@F2C>BCFDDG;4=@=@@E=;3=77;@7??B66>A>6>B;>A3@;#
@4KE
CGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGT
+
@@CDDFFFFDFHHJJJIIJJJJJIJJJIJJJJIJJIJJJJJJJJJJJJJJJJIJJJJIJJJJIIJIJIJGGIHIEIIJGHFGFHGDFFFEBEEECECDC
@4KF
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHJJJJIIHIIIII@FEHIIJJGIIIGIJIJJJJJJIIJIJIJIHHFFFFFEEEEEEDDDDDDDDDDEEEDDDDDDCDDDDDDDDDD
@4KG
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
CCCFFFFFHHHHHJJJJJJJJGIJIJJJJJJJJJIIIJIJHIJJJJJIHJJJJJJJJJJJJJJJJJHHHFFFFFFEEEEEEDDDDDDDDDDDCDDDDCDD#
@4KH
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@CCDDEDAFHFHGIIIIGD@EEGH?EGGHHHIIBFGEEHIGEGIGCGIIIIGIGHIIG@EHEFHFEHFFFCBBE?@@ACCDDDDCCCCDDDACCCDDDC
@4KI
ACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
?@@FADDFHFDFDEHHGBGICHHIIEHIGFDFGGD<@FBGGG4B<DB<FG?@BA@GGEGCGGHDFHHFDDFCAECB3>AC<CCB=BD9A(::@CCC(>@
@4KJ
GTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCN
+
@C@DDDEDFDCFHEFHHJJGHGICHFHHFGHIJIJGIIIIIJJIJJJGIJJIJJHIIGIIAEEHHFDDDBACDD@CCCADCDDEDDDA:ACDD858??8A#
@4KK
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAAAAGCTGGTAGGTGGGN
+
@@@DA;A:C4?FDG<4<ECFE3@@E@BDDCG9*::69D9@?BFDDF99B<48*8CBBC>FG7@FC=C7)7=B>?<B>(;6;(;?B(5>BBAB?(:1,(8>#
@4KL
CCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACA
+
@@@?DD?DFDDHHIDEGHIFGE=EEHI;FHCCHGG<FDE@@C<@FAGHIC?FGIIBHGIG;?;>C7AED@DBCECC;A;?B8;@BB<C2198<<ADCC
@4KM
GCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
?@<DADDAFDF?FFE3CGFECEAD;GFCG>GF?DDGID4DDEFEFFCEC==FFBFEECF;77CE>DEE9?;;?.;9=@BBBB(3;85<@7((:@>BAB
@4KN
GGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTTACTGGATGATGTGCACCACGCGGCCCAGCN
+
@@<?DDADH;<::?FAB@A?9AEBEG;<D9CG<?9D;8B<6;65AGB;3?;;?B>;7;6;/>88?<?<2,((+4++>3(44:(4+4:9?B209B<<B?@2#
@4KO
CTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTN
+
@C@DFDEAHGHHHIGFHGIHEIGGIFGIIJGIGIGGIIGIIIJJDAHIIGIGHDHHFFFFFEEED@@B?>ACDDCCC@CCBDBDD?CD>CDDCCAB:C>C#
@4KP
GGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATN
+
@@@DDFDFFDFGHJIIJIGGIJJIJIGIIJJIJEIGIIJIJJIJHJJJIIGIJJGHIDHHGGIDEEHIHHHEHFFFDFFEAC>C;@CDEDDDDDDDED@C#
@4KQ
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
@C@=DFDEH@DCDFFEHGGHGHGGAHHEHGABBFHGHCHCFGCGGIIEEBGGB===CHIFGGHCEHEEHE>@CEFCACEEEEC@>CACC>;@@CCC::>
@4KR
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
CCBFFFFFHHHHHJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJHHHFFFFFFEEEEEEDDCDEEDDDDDDDEEEECCD#
@4KS
TTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGN
+
CCCFFFFFHHHHHJJGIJJJJIJJJJIJJJJJJJJJJJIJJJIJJJJJIJJJHHHHFFFFFFEEDEEEACCCDEEEDDDDDDDBDDDDDDDDBACDDD09#
@4KT
GCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGT
+
@@@FFDDDFHFBDGHIIGFFGGEGGIIIIIGIIEFGIEHGHIGIGHIIIIIGIIIIIGEHHEFFFED39>?CCDCAC??B@DDDCCCDCDDDACBDB<
@4KU
TGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATN
+
CCCFFFFDHHHHHJJJIJJJIJJJJIIIJJJJJJJJIGHIIJJJJJJJJJJJJJJJJJJJJJIIHGIJJJIJJJHHCHEFFF@DEEEEEEDDDDDEEDDD#
@4KV
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFDDFHHFHJHGIJJGIIJEGHGHHHI:CGIHIJJJJJFHIJJGIJIJIJJJJIJIJHHH=?BFCEEDEEDCCDDDDDDDDDDDDDDDEDEEEDCC#
@4KW
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
?@@FDDDFHAFFHII@EHGHHIIIGGIE?FDFCGEIIEIFIIIIIIFIGGGGGGGIGGCGGHHF<>>BCCCCCCBB=@BCCCCCCCCCACABB@9<BBCC#
@4KX
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@@@DAADDFAHHFGI@@FC9GBFIIGGFGGEGE>D9@F>FHGCHDE@GIDAAFHG=;FHGID>DDGIHCAECDEE>@>>BB>98@@':>CCCCCCBB?BB#
@4KY
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTGTGCATATCCTTG
+
?=?D4BDADCD?FDB;<EG<AFD:CCAFBB??GB:99)1:::?:BDB?D??<FFB??F@F<8C;@@88CC=@@A>>?EA'3>B5?9+44:>B4:44::
@4KZ
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCN
+
<@BDDFFDFHHHHGGIIIIIJJJIIGGJJFHDGHIIHHDHGIFHIJIJJJJJIIJIIEFBGEFGIGAHHHFHHFFF>CCEDEDDDDDDDD<A>C@>><<@#
@4L0
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CC@FFFFFHHHHHJJJJIIJHIJJJJJJJJJJJJJHJJJJIJJJJJJJJIIJJJIJJJJJJIIJJJJJHHHFDDDDDDDDDDD@CCDDEEEDDDDCDDD
@4L1
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFFFDHHHHIIJIGJIGHIFGGIHIJI1CDGIJJIJJJDGHIIFHIIIGGGGGIHCEHFH4=DFCDEDEED>ACDDDDDDBDDDDDDACDEEEDDD#
@4L2
GTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGCGGTACTCCTGCTTAAAGCCTTGN
+
CBCFFFFFHHGHHJJJGIJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFDEEEACDDDDDDDDEEEDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDD#
@4L3
ATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
CCCFFFFFHHHGHGJJJJJJJJJJJJJIJJJJJJJJJJIJJIIIJJIJIIIJJHIHHHGHFFFEFFDEEEEDDD?ACDDDDDDDDDDDDDDDDBD>BCD
@4L4
GTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTA
+
CCCFFFFFHHHHHIIHJIJJJJJJJJJIJJIIJJJJJJIJJJJJIJJJJJJJJJJJJJJJJJHJJJJJJJIJJIIHHHHHFFFFFFFECEDDDDCCCCD
@4L5
GGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTN
+
@CCFFFFFHGHHGIGIGIHJJJJJJJJJJHIG>HDGIJGGIIJCHGBF@G@EHBHGGIFGHC>FGBHGGGIHGGGGIHFGHEHFDDCBEEDCECBBCCC@#
@4L6
CCCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CC@FFFFFHFHHGJJJJJJJJIJJJIIJJJJIIJJJJJJJIJIIJJJIIJJJGIJJJFEHFBEDEEEDDDDDDDDDDCDDDDDCDDDBDDDDDDDCCDDD#
@4L7
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATN
+
@;@DD?DB?C:FC@FFBG;HH:FHEFHCF@DAFF?<F@B9;B9B?099?1?BFC;)75A@7-;>AC>DDBBDDCCC.;?3->>@>>A:@BBBBBBBBB:@#
@4L8
GGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTCTCAACGN
+
CCCFFFDFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJH?EHHHHFFFFFDCDDDDDDDDDDEEEDDDDDDDDDDDDDDDDDDDDDDDDDD#
@4L9
CTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTG
+
@@@=DDDDH?:CFFGEEHIGIEGHGIGIEIBFDEFGGHIDDGGH@@DGGFHGDHGHHIIA=CDDHGCHDB935;CC5ACCC@@CCCCCCCC@CCBCB
@4LA
CTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTN
+
@@@FFFDFHHDHHGGHIGFHGFHHIIEHGGGDCGGGGCGIIGEFGIJIJIGHIJJJGIEG?CCGGIJGIGIGIIGGFEEHAHH;@CEFF;@CCCCD>CCD#
@4LB
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTN
+
@?@DB??D@;?FBAE@?:<FGD9<99:911:C*:0)?9BB/9??8.7CAF38/=.7CE=6755;BDD?;,,555;;55A?(:ABA>9<3?&3:::+>:A:#
@4LC
GTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTN
+
@?@DFFFFBFHHDIDI@EHIFIIDDG<GGGGCHIIHIIGGHIGCGGDDHIDEEEIIICFGIEGGEGDHFEEBDEF(9?;BB38>@@CCAC@CCCCC@@B9#
@4LD
CTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTG
+
@@<DADDD?FDD?1CFHGIEEHDA;+?9C9EEH@CD>4BBD>DH<DECHGGE@BFGG>FHG/(:'.)((.;<5>;;;@(:ACC@9?@BBA?(9>CA?C@
@4LE
CCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCTTCTGCCN
+
@?@BDDDDHDDFHFGGGDIJIJJGIJJJGGEGB?CEGIHJIIJCFFDGIGHICFHGHGIHGIGGFGIGHEHGHGHHGG>DEEDEFEECDCEDCDDCCCC:#
@4LF
GTCAACATCGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATGTTGAACAGATTCCTCCATCATCN
+
???DD:DD+<<DDEB??CFBB@F;?+)1):1:C:B8*::9DBBD90809?89)8=BB8.@C:8@@6.77).)=C2?DDEA@;6>A?3>;5-5;>,(,(:A#
@4LG
GTTTTGTCTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGAGAGTAAGCTN
+
<@@DBAD8::DABEF:<A4CB?CAEGDH+<FE9??EFFB:9*??<9B?FD><?88D?BE*=48=(@).5=>;2)7A>7777)?BDCB@>;;>>3-5@>AB#
@4LH
CTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJIJJJGJJJJIJJIHHHHHHHFFDFFFFEEEDE#
@4LI
TGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATN
+
??@++AD;D?<CCD<EAFFIEEEE<A?CE?C??*CFBCC>BDFIII4@067<BB8);CFBEF2===)==;DBD;5;AB@BB>A55;>A;555>BBB:>;;#
@4LJ
CTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGN
+
@@@DDB?DBCD?FGIICEHGID@HIGGAFFHDHGCGHHIBFDCFCFFGGEGIBGGDGG>@DBCAFHHG:CADFHICHHHCEEFHHFFD?;C76;>CE@CC#
@4LK
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGN
+
BBCFFFFFHHHHHJHIJJJJHIJJJJJJJJJJJJJHHHHFFDDEDEEDDDDDDDDDDDDEDDDDDCCCCCDDDDDCDDDDDDDDDDDDDDDDDDDDDDBD#
@4LL
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJFHFHIJJJJJJJJJHHIIJJJJJJJIJGJJJJJIJJIJIHHHFFFCEEEEEDDDDDDDDD<CCDCDDD2
@4LM
CCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACAAATCACATCGCCATCTTCACCTTCAAAGCTTTCATTTATGN
+
@<@FFFDFHHHGDEFHGIGGIJGGIGGIGGIIIIIJICFGHHBFEDHGIGIJJIHHIJEGFGHC>FADHGIECEHCFFDDFCEEEEEDDDDDCCDDDDFC#
@4LN
CGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTG
+
CC@FFADAFFHHFIJJJJJJIJFGHIIIICGIHHBFIIJJJJJJJJJJIJJJIJJJJJIIJJJHHHHHFFFDDEEEDCDDDCDDDDDDDDDCDDDCBDD
@4LO
TTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTN
+
CCCFFFFFGHHHHJJJJJJJJJJJJJIJJJJJGJJJGIJJJJJJJJIIJJIIIIIHGIEGIJIJIJJJIJIJIJJJHHHHHFBFFCE@ECC@DDDDDDB>#
@4LP
GCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGN
+
CCCFFFFFHHHHHHIIJJIJJJJFHIHIJJIIJJJJIJJJIJJIJHIIJIIJGIHGIGHIFHIGIJIJJ@EHHAEFF5@ABCDDBCDD8?CCCCDDDDDD#
@4LQ
CGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTN
+
@C@FFFFFHGHHHIJJJJJIJJJJJJGIIJJJJIJIIJJJJJJGHIIJJJJJJJIJJJGHGHHFFFFFFEEEEEDEDDBDDDDDDDDDDDDDDDDDDDDD#
@4LR
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@@@DD:DDBDHHAHEBD:C?F@GIGIGGGBFDF@GEDFHGFBHICHA>FGFHFADCAH>=EHA@DE3;@3:>AA@>?=BB?>>>>CACCCACCBA905<<#
@4LS
CTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTA
+
CCCFFFFFFFHHGJIHIJJJJJJJJJJJJJJJJJJIJJIJJJIJJJJJJJJJJJJJJIIJJJHHHHHHFFFFFFFEEEEEEEDCDDEEEEDDDDDDDD
@4LT
GCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGN
+
CCCFFFFDFHHHHIJJJJJIJJIJJJJJJJJJIJJJJDHIIJIJJJJJJJJIIJIJJJIJJIIIJJJHHIHHHHEFFFFFFEEEEEDDCCDBDDDDDDDD#
@4LU
TTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATN
+
CCCFFFFFHHHHHJJIJJJJJJIJJIJJJJJIJJHHJGIJIHGIIIIIIGIJIIIIJJIJIJJJJJIJIJICHHHJIJHHHHHGFFFFFFFEDEDDDDDD#
@4LV
CTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCAC
+
CCCFFFFFHHHHHIJHIJJJIJIIIIJJJJJIIIJJIHIJJJJIJJIJJJJJIJJJJJJIIJHIJJJHHHHEHFFFFFFFFEDEDEDDDDDDCDDDDDD
@4LW
TCCTTATATTCACGAACCTGATCCACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTN
+
?<;AAD?AAC4=DB@F?<C?:A9C<FGBC??::CC@BGFGI@@G;DB?6BFCFCAF@>E55AE8;7;;;>;6@>6;;@BBB@>B@ABA;>;>5;@>:;>A#
@4LX
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTN
+
???BBBBFHDHHHDGICFFIIGIGIIIIIIGIBGCDFE<DHHBDG?DFEHIIGB@FAFHHFCCGGHEEEFFDBCCBEACBD9?BDDCAC>>@CCD4:?BD#
@4LY
CGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
@@@DFFFFDHHGGBEBHGHIGEHIHIJJIJIIEGIGJIJEGEHGIGGGIFCGEFIHGGIDIHHF:CD@@C;B@>@>A@@CDC5>B5<C?CD>CAC@CB
@4LZ
GGGAACTGAAAGCTCTGGTTTCAAAACCATTCTTTGTTCTCCCCGACCCAACGAAGTATATCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTN
+
@@@FFFFFGHHHHJJJJIFHIJIJJIJJJJIJJJJJJJJIJJJJIIJIJJJJIGIJEHIIJGFHHHGFFFFDDDDDDDDDDDDDDDDDDDDDDEEEEDDD#
@4M0
CGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJJJJJJJJJIJJIJIJJHHHHHHFFFFFEEDDDDDDDDACCDDDDDDDDDDDDDDD#
@4M1
TCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFDDDEDDDDDDDDDD@BDDDDDDDDDDDDDDDDD#
@4M2
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJIJIJJJJJJIJJJJJJIJJJJJJJJJIJ:BCAECEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@4M3
CTCACCTCTCAGACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJJJJJJHHHHFFFFFFEEDDDDDDDDEDDDDDDDD
@4M4
GCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCN
+
CCCFFFFFGHHHHJJJDDDDDDDDDDCCDDDEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDD>CDDDDACDCDDDDDDD#
@4M5
GCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGCTGAAATTGAAT
+
C@@FFEFFHFFHHJIJJJJJJIIIIJJIJIJHGHCGCIIIHIIGIIIJIHIIIIIIIIIIIIHIJIJIEIJIJGHIIGHH
@4M6
CATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCAT
+
@@@DDDDDDFFFF?@?<B<@B@DEGEGFFECHBFECFEGFAEEC@@FGCFH?@BGA@FDEEC)=?C3?>:??7;>@C@;@>ACACC>AAA=??AB>>A@
@4M7
GCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTN
+
@@CFFFFFHHGHHJJJJJJJIJIJIJJJJJJFIIJHIJIJGHJCHIGHGIJJIJJJJJFEHIIIIJIJJIIJJJJEHJIDEHIJHHHGHFFFFBCFFDEE#
@4M8
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGCCTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGGGGTAACTAGTGGGAGGN
+
;?@DD8ADF>F>?@DGFFG<EGEAE;FHEDHC3?FBDFH@B9B9D@FFF*94?=D=CEHEHIIAE6=?C@HEBDDEECCCA@/959<5A>::@@><?229#
@4M9
GTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTGCTCTCAGGN
+
CCCFFFFFHHHHHJJJJJJJJJIHJIJJJIJJJJJJJIJIJJJJJJJJIFJJJJIJJJIJIJIJJJJJJJJJHGHHHFFFFFFDECEDDD@BDEDDDDDD#
@4MA
GCCTGCTGCATCTGCTGATGGTGGTGATGATGGTGCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACG
+
@@@FDDDDHHD>DGIHGEHII?CF)A9AECFEGGEEFI:DG@FDFHHFGH@GAEBF=@GGFD6;;>AE>?CFF?>CEC;?;C>ACBBB=BCCCCBA?<
@4MB
TCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTN
+
CCCFFFFFFHHFDGGIJDIJJJJIIJJJJJJJJJJJJJJIJJJJJIFGIJIJJIJJJJJJIHHFFFEEDCCB;?CCDCDDDBDDDDDDDDDDDDDDD?CC#
@4MC
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGNNNNTNCNNNCATNNNAGTG
+
@@@FDFFFHGFFHIJFHHIIJIIJIIIEGIJGIGFHDFFC?GHEIGHGIJJDEDEEDCB?ABDDDBDDDDDDD@DCDE####+#+###++8###++28
@4MD
GTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGN
+
CCCFFFFFHHHHHJJJJJJHIJJJJIJJJJJJJJJJJJJJJIIJJJIIJJJJJJJJHHHHHHFFFFEDEDEEDDCDFDDDDDDEDEEDDDDDDDDDDDDD#
@4ME
ATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGCCCAAGTAGTCTCTCN
+
:?@7?D82AFACFABGBF:FG2<1:1CEFBC>FED@FB008060<:FFD@EFD9..==C7B(;776;>>;=@=?BB28;000<<<(22282+4(+4:@@>#
@4MF
ACTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGN
+
BCBFFEFFHHHHHJIJJJJJIJJJJJJJJJJFHGIJJJJJJJIJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIJIJJJHHHHHHFFFFFFEEEEEE#
@4MG
GGCGGAAGGCCTGGAGGACCCTCCTGGCTGACACCAACAGCCTTAGAGGGCAGAATGGTCTTCACATTAGATGCTGTCACAAATGGAGGTGCAGGACCCTN
+
@@@DADFDBFAADEEBEEEEHGIGG??BDHIGJJJJJIB@FHGIJIJGIEII<EEDDEBBDFCDCEDCDCCCDDDCDDDCACBDCDD?B?BCACB@ABBC#
@4MH
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
@CCFDDFFHHFHHIJFHGIJGJIJJJGHIJJJJJIGIEGFGCHGI=FH@FDHGGGEHIIHEHHGHFFFFBFEEEE>CDDB?@?CDDEDDDCDDDDDDCDD#
@4MI
AGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGAAACTAGTGGGAGGCTGCTGCCCATAGCTGCN
+
+1=D;@AA;A:AC<E9C@:CCHI9?FA>ED<FBDE@CFD308?DF>9B/?<8)8BFFG7=@A=EFE989(>=ABB;;A<9@<2<++<:+:8<A?((4::9#
@4MJ
CGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGN
+
B@CDDFFEHFHGHIIJIIIIHIIJJJJHHIJJJJJJJIJGJJJJHFDDDDDEACD?CCCFCDDD;BBDCDDDDEDDED@CDDDDDDDDDBDDDCDDD7<B#
@4MK
CCTCGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCN
+
CCCFFFFFHHGFHIJJJGJIJCGIIIJJIJJHHIIGIGIIIJGIJJJJJJIJHHDDDDDDDDDEDDDDDDCECDDD<BDDDDDCDECCEDACCCDDDDDC#
@4ML
AGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTN
+
@C@DFFFFHHGHHJJICGHHHIIJIGIGGEIECFHGEIIEGHHGGHGHHAGGGDHEIIEIIJJJFIHGEHIIHGHGHHGIJHGEEHGHGHHFFB@DFFED#
@4MM
GGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGT
+
CCCFFFFFHGGFFJGHIJJIIJJJJJIJIHHIHIJJIJJJJJJJJJJIIIJJJIJJJJJIJIHHHHFFFFDEDEDEEDDDDDDDDDDDDDDDDCDACC>
@4MN
CTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTN
+
BCCFFFFFHHHHHJJJJJJHFACCHHIIIJJJJJJIIJJJJJJJJIIJJJJJJJIJIIJJJJJJJHHHHHFFFFFFFEEEEE@BDDDDDCDDDDABCDAC#
@4MO
GCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCN
+
@;@BDDDFFHHHFGIB<GIIICGIIFDFGDDACGIIBCFHGIGCCEFEHEGEHEEHHEHEEEDEC?CDCCC@A>CCB>=;?BAC422<?@>>@CCCCCEC#
@4MP
CTAAAACATTCTTTCCTCTTTTGTTGGATGGGAAATTCCATTCTGTTCCACATCAGCTTATGCATTGGAAATTTTGTATTTGGGGAAAGAGTGGTCTCTCN
+
CCCFFFFFHHHHHIJJJJJIJJJJJJJIJJIJJIJJJJJJJJJJJJJJHJJIJJIIJJJIJJJJJJJIJJJIJJJJDAHIHHHGFFFDDCE;>BCACDDD#
@4MQ
AGCTCGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGGTGGGATCCTTCAGGGCCTTCACAGCCACAAGCATCTTGTCCTTGGTCGGGCTGAGGTTGTN
+
@CCFF<@?DHBDFBHGEHIEC?HGHHBH?@6?@FGFFHIEBFGGIIGHEHHHHB;B??>AE>A@ABBC?BC@9@CAC@CCCCCCCCAB<BBB>?<BCBCC#
@4MR
AGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTN
+
@@@DDFFDFFHHFHIDIIJGGHIIEGHCDDAHIIIIJCGIIJIJIGEHIJIIIJHHHHCHFFDDDDCCCECEEDDDDDDDDDCCCC?ABDDDDBBBB:>A#
@4MS
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
@@@DD?2BFDFA<@DAC>C?CBGDFA?F4C9?ECGBD?BH<<DFB?09?FF@;FB<F@FIE/7(=ACC?>DEECEC@;;@;;AACCCCDCD>>CCCC35
@4MT
CCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGN
+
?@@D?DDDFHHHFIGHGH>FHHCDHHF<8CDBAHHEBGHHGEHEGGIIICEH@DCCACAE;7?DEBCCCC@CCBBBBCCCC>@CCC?99@3)::C:C:<5#
@4MU
GTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
@@@DDDBDHFFFFHIIGHIHFEEHIGCGHGGFHIHGGGGIGIIIDGGGGHBBFFHDHICHEAHDAGHDC>A?ECBDFFDACCCDEFDDCCCB@@BB>C>
@4MV
CACAGATCATCAGGACAATTTCTTGGTGGCTCCAGTCTCCCTCCTGTTTGCACATAGTTTAACACATCAAGGTTGGAATGAGCTGGATAAGGCTGATGACN
+
@@<BBDFFDHDFFEHIGHIIIGIBHHAEGHIGGG<9CFFGGEH;FGH>BBGGFBGFGFGGGIIGEGIAHHII7?CEE>;BBDC@@>2;@@A@>A?9>(;>#
@4MW
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATN
+
BCCFFFFFHHHHHIJIHGIIHHIIAFGIIIIJHIIDGHJJJIIJJJIIJJJJJJJIIHIHGHHHFFFF?CEEEEEDDDDDDDDDDFCEEEDDDDDCDDDE#
@4MX
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTN
+
BC@FDFFFHHFHGGHIIJIJJIJJJHIGJJIIIIHJJJHIJJJIGGGIJIIJJJIHHGHGIIAHGGHGIGIHHEHHADFFFEDDDDDD<>@CDDDCCCCD#
@4MY
GATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGN
+
;?<DDDADFHDFFEDCBG<A<AGD@HD<AFG?CEEHF??GGIID4?DDB9D08?FHCH@BCCGIIEB;?;;6;;@CCACC??BB>ACCCCB@?C?B<>@9#
@4MZ
ACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAAT
+
CCCFFFFFHHHHHIIJJIJJJJJJGJJIGGJIIIIGIJIJJJJIHHGGIIJJJJJIIIGHIJJJJJJIIIIFFFHHGFFFFFDDDDD?CDDDEDDDDD
@4N0
CAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATC
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJGHHHHHFFFFFFEEEEEDEDDDDDDDDD
@4N1
GTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGN
+
@??DDFFFFFHFF@><CFGGIEGHGHGGGG<FHIEECHHFGJIJIIEE;AE7?B@@ACCCDECE@CDCCDDDC@CCD;>@C>ACCDEACDCCD0)55<AA#
@4N2
CAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGN
+
@CCDFFFFGHHGHIIIJGGIJIJJJJIIIHGIIIIGIIJIJDBDDACDD@C>ACCDEEDDDCBDDDD?BDD?BDCDCDDDDDCDACDDDACDDCBD<@BD#
@4N3
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTN
+
BC?DDEFFHGGFHIJHIJJJJJIJJJIJJJJJJJJJJIJJJJJJJIJJJJJJJHHHHHFFFFFFEEEEDEDDDDDEDDDCDDDDDDDDDDDDDDDDDCCD#
@4N4
GTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACAC
+
B@CFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJIJJJJJJJJJJJJJJJJJJJGHIJJJJIJJJGHHHHHHFFFFFD
@4N5
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
CCCFFFFFHHHHHJJJJJJFHIJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJHHHHH?BDDEEDDCDEEDDDEEDD
@4N6
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJGHIGHIJJJJIIIJJJJJJHHHHHHFFFFDDDDDDDDDDDDDCDDDDDDDDDEEEEDDDDDD
@4N7
GGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCN
+
@@@DD;DB<CDDHAAFEHB@AAF6??@ECHBHBG@CFEG9DFGGEE409DH?3?A;FHHHB@=@AH@@EEFF>8;AC@ACC;>;;>CCA??A5>::>>>:#
@4N8
CTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGN
+
BC@DDFFFHHHHGJJJJJJJJJJJJJJIJJJJJJJJJJJJIJIJJJJIHIJJJJIJJJJJJJHHHHHHHFFFFFDD?BDDDDDDDACCCDCDDDDDDDDC#
@4N9
GGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTN
+
@@@DFFFFHHFDHEFGGGGIIJGAFGGIIIIGAHGIAG@FHHGIHIJCEHGGIFAGHGIJIG:?8>CC<@AC?=BDDCDCCCCCDDDDDDBBDDDDACCD#
@4NA
CAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJGJJJJJJJJJJJJJJJJJJIJIJJJFHJGHIIJJJJJJJIJHGHEHHFFFFFFEEEEEEEDDDDDCCDDDDD#
@4NB
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
CCCFFFFFHHHHHGJIJJJFIIJJJJJIJJJJIJJJJJJJJJJJJJJJJJGIIJJIJJIJJIJJJJGHIHHHHFDFFFEDEEEEDDDDDDDDDCDDDCD
@4NC
TTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTN
+
=?:BDDEBHHFAFBHGHB<AEIHFIIIIIACEHGGGGGHHDGGGGCFBFHIGIIIGBGHIIGHCGEHIGIIIIIIBCEHAHIIIEAHEHH@CCDFFDEEC#
@4ND
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
B@CFDEFFHHHHGIHIIIIIIHIIJJGEFGHJFHJJIIJIIIJGGIIJJIIEGIIIJJJJJHGHHGEDFFCCAC>ACDCDDDEC>ADDCCDDDDCDDC
@4NE
CGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGGGCAGTGACTGGCTGCATGGGGTAGCN
+
@CCFFFFFGFHGHJJIJJJJGIJJJJIJJJFGIGIJJJIIHGIIIJJJIIJIJJ=.)=;7=F@(.5?37?1;@A'39;,5555,:2<3<834@BD7&00:#
@4NF
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTN
+
?+=?D;DBHFC;DHBCEEDEDHHGEHEBF)):<4:*::09BF909?7?CGIGB==AGCCCA=EECHD>BBC@CCC@:@CBBBB<B:35::@(+:>CCAB@#
@4NG
TGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACN
+
CC@FFFFFHHGHHJJJJJJJJIJJJJJJGHIJJJIJJJJIIJJJJJJJJJJIJJJIJJJJJJJJ@EHBDFDDEEEECDDDDDCCD@BD;CDDEDDDDDCD#
@4NH
CTCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTGN
+
CCCFFFFFHHHHHJJJGHIJJJJJJJJJJJJIJJIIJJJJJJJJJIIJJJJJIJJJJJIJJIHHHHHFFFFFDDD?CDDDDDDBDDDDDBBBD>CCDDDC#
@4NI
CCCCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGGATAGGN
+
@@;DDDDDHHFBDD2AFDGB<,ADEGEHIGCH:@F@GGGHIFIGGIIIFFHHFHEEDBC@CCC>;??<;?A?CC?CCC@>4:4+>@<@BC?3@@C?@CC?#
@4NJ
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
C@@AFFDDHFDHBHIGDFBFCHHEHIGH<FF>HEEGGIGHIIIAHE<DGGFEFF<FGFAGFH;FHH7@CEEEHFD;?B@AABDDB@BCCCACACCDBBCD#
@4NK
CCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATN
+
@@@FBDFFHHHGFIFE>@>GGHIIGIIIBGGIIIEI9DCFHHGGGIFGG?FHIEHBCGEIGIII@HICHCEED)9A,;?,5:ACCCFCCCC>CC+8<<@C#
@4NL
ATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGC
+
CCCFFDFFHHGHHIJJJIIIIIJJIIJJJIIJJIJJJJ?HHHIJJGIJJJEIHIIIJGIHJJJJJIIJFHD8=@CDDDCDDDDDDCDDDDBCDDDBDDD
@4NM
CGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGN
+
CCCFFFFFHHHHHJJJIJJIJJJJJJIJIIIIIJJJJJJEH/=ECHIIJJHHGHHHFFFFFFFEEDDDDCDDDDDDDDDDDDDEDDDEDDEEDDDDDDDD#
@4NN
CTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCN
+
CCCFFFFFHGHGHGHIIIJJJJJIIJJJGIJIJJIGJJIJJJEIIIGIGIIGIJIIGHJJJJIJJJJJHHHFHFFFFDFDFEEDCDDDDDDBDDDDDDDD#
@4NO
GTTCCACATCAGCTTATGCATTGGAAATTTTGTATCTTTAAAAAAGATTTGAGGAACAGAACTGTGTTTTGATGTTAACAAATTGTACGAACACAAGACTN
+
C@CFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIJFHHIIJIHHHHHHFFFFFEEDEEEDDDDDDDDBCDD#
@4NP
ACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGG
+
CCCFFFFFHHHHHJIJJJIJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJJHIIJIIHHHEHHFFFFFDEDDDDDDDDDDDDDDDDDDDCDDD
@4NQ
CCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCN
+
=?@DFFDDHGAFFHGIIIGGIGIGGGIHGIIIIDIIICEHFGHGGGGIIIIIHIIIIDIIIIHIIGHGEHFGEEGIIDEGBHIIFGHHHHEDEBEDCEEE#
@4NR
GGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTN
+
BC<DFFFFHHHDHIJHIIJFHHIHIJJJJJHIJJJIIJJJJIIJJJJJJJJJAGIIJJIJHHHEFFFFFFDDDDDDDDDDEDEEEDDDDDDCDDEDDDEE#
@4NS
TTTTTTTTGGGCCGCCTACTGGCTACGACGTCGTTTCTTCCTTCTGCCCGTGACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTN
+
@CCFFFFFHDFFDGIIIIIJIIJIJIIIIGIHHFFF@CEEDEECCCCDBBDDBDDDDDACDCCCDDDDDDDDDDDCDDBDDDDD8C>CBD<A@BBDBDDC#
@4NT
AGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTN
+
@@@FDDFFHBFHHHIIIIFHIIEDDD@GHHFFH@FHIGGBFGFCGFHIIGIGGG7DGCEEHEHFFFFFC@CCACCCCDDDDCCCBDDCCCDDECDDCB@+#
@4NU
CTGGCATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTN
+
CCCFFDFFFHHGHJIIJJJJEHJJJGIJJJJIJJJJIJIIIJJFGIIJJJHJJIIFGHHIJIHGIGGIIIHHHHHHCCDFDEDDDDDD9@>CCCDCCDDD#
@4NV
CCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATGTGAAATTCGTTCCTGCTTAATGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJGIJJJJJJJJJJGHGFFFDDE@BDDDDDDDDDDDDDDDDDDD8ACCDEDEEEDDDDDDDDDDDDDDDDED#
@4NW
TGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATA
+
@@CFDFDFDDDH?FDGHIIJJJJJGGGHIGIDCHIIIEIGHGGIGFGGHIIIIGGHHHIIGGDGHEGEACDEHGGHEEDEBCECCECCDDDD;@CD@CC
@4NX
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@C@FDDFFHHFHHJJJJIGGGHJIIJIJJJGGGIIIJIIGIIJJIJGHIIEAAHGHEIJGIHHG'=A>@CDDDDDD@DDDCCDCCD@CDDDDDBDDBBCC#
@4NY
CCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGN
+
@@@DDDDFHHHDAGHIIJJJIGHGHIHEDFHIJJJJJHIIIDGGIIIGJIJIIJJJJHGHHFFEFEEEEECCDDBDBCCCADCDDDDD&9@@CCCCCDBB#
@4NZ
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCN
+
@?@D?3ADFDABFDF>BGEE@FHGIGIIG>BBA@6)??@?C<.8<=8@F@F9D@;).=A)?A;>;=ACAA363>;55@;@>5>@C98?8+4+:>::>4:@#
@4O0
GCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCN
+
@@@FDFFFHHGHHGJIIIIIGIIIJJJIIIJGIHJGJIJJJJJJGHBDA<AEDDDDDDDDDDD:>BA>ACCCDEDDCDDDDDDDDDDDBDDBDDDDDDDD#
@4O1
CCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGA
+
C@CFFFDDHHDHHIJJJGIJJJJCEHGIJJIIIGGIIGIGIHHGEHIJFHIJFGFFFDBCECDDBDDDCDDDC>CDDDDDDEDECCCD8?@>BB<BBBD
@4O2
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
CCCFFFBDHHHBDCFBB??FHDFCFHBGC?C@FC:??F@D@HCBHD>F?FDB@B88==F==FACCGA@=@=7=<85=;>;6>35=5;;:>5;>C5>><
@4O3
GCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGA
+
CCCFFFFFHHHDFGIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFDDEEEDDBDDDBDDDDEEDDDDDDDDD9>B
@4O4
GCCTGTATCAGCAGCGGGGTGGCCATGCGCATCTTGCTCACAGGCTTGGGAGGCTTGGGAAGCTTCATGCGCAGGTTCTCCAGCTGCAGGTTCTGGGAGGN
+
:=?D?D>DF8=DBA@@@GE?DFEB3=FAEFAEIIA)7A>AEDB;B;>@===B?B?@=8<?B88AB:A:4:)0900++4:>:::9:(39><?AA:@A@?20#
@4O5
CTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCN
+
CCCFFFDEHDHGHJJGGIIGGIIJFGIIGGGHGDGHGEHCAB9BBEGGEIIAFGHEHIJJGJJJICHHGIEHHFHHHFF7@DEDCCCD?B@BBDDD>BBC#
@4O6
GCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCN
+
CCCFFFFFHGHHHJJAGIIIIJHIJJJJJJJJJIIJGHIJJIJJJJJJEHHHFFFFFEEEEEEEDDDDDDDDDDDDDDDDDDDDDCDDDDCDDDDEEDEE#
@4O7
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
@@@FDDFDDDHHHJIIFHHIGIJIJIJIIGJIG@HGGIJJJJIEIIIJJECHHIJJIJJJHFEHF8>B>CCDDCDDDDDDDDDDDCCCDDDDBBB9@DDD#
@4O8
GGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACN
+
CCCFFFFFHHHHHJJJJIJIJJJJJIJJJJJJJJIJJJJJJJHIJJJCHIJJJJHHHHHHFFFFFEDDDDBDDDDDDDDEDDDDDDDDDDBDDDDDDDDD#
@4O9
ACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAG
+
BCCFFFFFHHHHHJJJJIJJJJJJJIJJJJJJJJJJJJJGIJIJJIIJJJIJJJIJJJIJJJJJJJIIIJJIHIIIGGJHHHHHFEFFFEEEEDDDDB
@4OA
CGGGCTGAGGTTGTAGCACTCGGCCAGGAAGACCTTTCCAAAGGCTCCCTCACCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGCTGCAC
+
B@@FFFFFHHHHHJJJJJJIIIJJJJJJJJIIJJJJJJJJJJIIJJJJJJJIIJJJJJJHHHGFFFFEEEEEDDDDDDEDDDDDDDDDEEC@CCDDDDD
@4OB
CTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJHIIJJJJJJJJJJJJIHHHHHHFFDDDEDDDDDDDCCDDDDDDDDDDDDDDDDDDDDDDDDDDD
@4OC
GCCTGCATCAGCAGCGGGGTGGCCATGCGCATCTTGCTCACAGGCTTGGGAGGCTTGGGAAGCTTCATGCGCAGGTTCTCCAGCTGCAGGTTCTGGGAGGN
+
CCCFFFFFHGFHHJJJJJJGHIJJJJJJJJJJJHHGHHHFFFFFDEEDDDDDDDDDDDDDDDDDDDDEDDDDBDDDDDDDDDDDDDDDDD<CCDDDDDDD#
@4OD
GGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGN
+
@@@DDDFFFFBFBHGIJIIIIIHGGGGHGIJJJJJFAFHGGIIJIIIEEGIHGHHFDFF@CACD@BBCCDDDDDDDDBDDDDDDDBCDE>@C9>AC@CCD#
@4OE
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGN
+
@?@DFFFFDHFHH<FBHHECFFHDGHHIIIICGDDFGGHIGIIIIIIFGHGG<FB=FEGIIG=ACAC7A;B>CBCECDECCCBCDB@5>??(:@?>A@88#
@4OF
GTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCN
+
?<?DD44B>DBDBED4<EF>@EFCAEECDCD4+C2<4A9<DF>EC**:D9D<?BD@?B4?:9*989BD@CCC<B)=@=ADEAC@CC@)??377=A.;?:;#
@4OG
TGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGT
+
CC@FFFFFHDDFHGIGGGCEEEHJFHDCBC>FDGBFIGFGGEIGGIIHHIGGIIJGH<CGEEGIID@FHEHIJJGHHGAB=BD?EEAA@AA>>CAD(5:
@4OH
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
CCCFFFFFHHGFHHGJIJJJIJJJJGIJIGHHIIGGGIIJGGFFGIIJJIHIJIIJJIGHGIIGJJIFIGHIIJJAEEEFHHHFFFCDCEEEEEEEDDD
@4OI
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@=?BDDDDD?>CFFB@EEAAFHGECCHFGG?DFBHCH@GHIED?GBGGHFFIGC@;ADH=CEEHC;ACEDCB@;AC6>@1AC;;,:55::>@C@@(2@
@4OJ
GTCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
BB<DDFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJIIJJJJJJJJJHIJJIIJJJJJJJJJJJ@EFFACEEEED@CDDDDDDDDDDCDDDDDDDDDDDD#
@4OK
GGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCN
+
CCCFFFFFDDFHFGIGGICHIJJJE)CCFHIJICEBGGCF?DBBDHGIFGHGAADGHEEHFFB=4;@C@CACDA?;=BDDB?><9@B<B(>:CCD4>>:A#
@4OL
CAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGN
+
CCCFFFFFHHHHFIIIJJJJJJJJJJIJIJIIJJJGIIIJJIJJJJJJJJJFIJJJGHHIJCGIJJI@DHIEHFFFDECCEEEDCEEDDEEDEECCDDDD#
@4OM
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CCCFFFFFHHHHHJJIIJJJJJJIJIJJJJJJJJJJJJFHJJJJJJJJJJIIIJJJJJJIIIJJJJIHHHHFFFFEEEEFEEDDBDDBDDDDCDDD>CD
@4ON
GTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGN
+
;=?D:=;::+AAFF@<G@D4CFFFCEC+??;@1:CFBFF@BFFF>D@4B;<BFBAFBAD=777@EEAAE:ABD3?B@AAA66(;5:3>>7,(53(5:?<?#
@4OO
TAAAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCATGAAGAGCAAGCCCCCTCCCACGTATGAGTCGGAGGA
+
??<D=D?BFFDDBCEHIIFIIGGIEEHIIGIECGHGGEBG>D@@DGGGGGIIGIIGIA88B<@DEEECECCCCB?BB?BBBBCBB<CC?>C4@@B&59?
@4OP
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCN
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJJJHIJJJJJIJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJHHHHHFFFFFFDDDDDDDDDDDDDDDD#
@4OQ
TGCTGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGTTCTTCATGGGCGCTGGCTCCTTCTTGCN
+
<@@?BDDBFAHAD:EG@EFHEEGH<@BEFACC@?FGGC?CFGICHFGG)@@<@=B4=8=CABACHECBBBB=(5:>>:4>>>?B59>B>8348?AC@>CC#
@4OR
CCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTN
+
CCCFFFFFHHHFHGHIIIJIJJJJIIJJJJGJHHIJIGIBGGHIDHGJJJIJJJJJJIJIJJJJJJIJJJJJIIJJIGGHEHHHFFFFFDEDEEEEDDDD#
@4OS
CTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTN
+
@@;DDDDD?FA:DFFEHIGD>FEHH><EH>HG?A<BEHG@<FEBDAGBHGG?DCC@DE?GB?DGCC@D;BDGHGIIIEGGI;==CC>7?E)..;;B@C6>#
@4OT
TTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTC
+
@CCFFFDFFFFDDGGGIIIGDIGIIIIGIIIDHIIEHIIGIIEGCHHEHDAGHGHHIGIIIIGBGHIIAFFGGIIII8C>@EGGHCHFDBBCB;?@ACA
@4OU
AGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTN
+
@@@DFFFFHHHHGGIIJJJJJJJJJJJJHIJJIJJGIIJJJJJJJIJJJJHGHIJHIJGIJJJJJJIIHHFHEHFFFFDDEEDDDDEDDDDDDDBDDDDC#
@4OV
GCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACN
+
CCCFFFDFHHHHHJJJJJHIJJJJJJJJIJJJJJIJJJIJIJJJJJJJJJJJJIIIJJJJJIIJJJJGIHGIJCHGHIJJJHHHHFFFFDDEDEDDDDDD#
@4OW
TTGTGTTTTCATAGTCTGTAGTTCTAACTGGTGTATTTTCTGAAGTTCCTTGATCTTTTCCTCTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAA
+
@CCDFDFFHHHHHJJJJJIJJJJJJIJJJJJHHFHIIJJJJJGHJIHIJJJJJJJJJJJJJJJJJJJIJIJJJJJIJJJIJJJHHHHGHFFFFFFEE
@4OX
GTATTTTCTGAAGTTCCTTGATCTTTTCCTCTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCTTTATCTTTTTCATTTTCCATATATTCACGN
+
CCCFFFFFHGHHHHHIJIJJJIIHHJJJIJJJJJJIJJJJJJJJJJGIJJJJJJJJJJJJJJIIIJJGGJJJJJJIJJJJJHHHHHHHFFFFFFFECEED#
@4OY
GTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATN
+
BBBFFFFDHHHHHJJJJJJJJJJJJJEHGHIJGJJJFHGHIJJJJHIFHIGHIFGHIJJJJJJJJJJJCEFFFE>CEEEDDDDDDDDDDCCDDCDDDDCD#
@4OZ
GTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTA
+
@?@DDDDDDHHG?AFHEDGGHIJJEFCE@FGF?C?DHGGIJEDHEBFCEBDGGFHG@E>EECEEHHHGHCDC@DFFEECCCEE>CDCDD@9?BB<>@<C
@4P0
CTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCN
+
@<@ADB:=C<CDF;:<A?ICF:<E@?3FF;21?C9CFDDDCFH<DD>DF<0??BFHDHIF8888@6CE@EC==C;;(74;666>66;;;@?BBBBAC<>C#
@4P1
CTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATN
+
?@@D;DDDDHDFF@CFI<ED@HDHBC9@CFGHIHIIB?EHCHIIIIEHEGDHGHI;;CGEFHIIIIHGEHHHHAE;;CFDDFCECEDFC@@CCC;@CDAD#
@4P2
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGGAGCTN
+
@@@DDDDDHHHFH@F<<AFCFGHAHFGIGCHB?D:FGB@??F<DB8?BDGCEG@)=CH=CGI;CEEAHBDC@BCCCC>;@>@>AB@C?B>ACBBB&)098#
@4P3
AAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGN
+
?<?>?DD?:C<DD:E@2CFCB<<C:3<CA<FEFAB@EB<@DBFB@BD?D43?9BB?BDADCDAAA-7=9;@=A>??=C@2);>;6>>>A:6(55>5(5:>#
@4P4
ATCCAGTAATCTTAATATGCAACTCACAAGATGCTAGGAGACTGAGAATTCAAACTGGCATACTGGCCCATGGAATTATTCATCTCTTTGTTCAGGT
+
???DDDBDHBHHGGHHGEEEHGCHDBEHBBDFDH@GI8:EGAFCGCFIIGA?FHEBBF@?B=CBBFCGE;EHIGDAHHAEAC@@>>@?D;;>;>;;A
@4P5
CCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCC
+
CC@FFFFFHHHHHIJJJHHJJJJJJJJJJJJJIJGGHIJJJIJJJJJJJJJJJJIJJIIIJJIIIJHHHHHHH@DFFFFFEEEEEEEDDDBDDDDDCDD
@4P6
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGN
+
@?@FDFFDFCAAAFHIIIJIJGJ?CDEHHIJGIJIGGCHICGIIIIGHDHHIIFIJIJDHAHEH@>?CDDB@@ACCCBD?CCCAC@@>A@CCCDDDCDDD#
@4P7
AACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGN
+
@@@DBBBDCCFHFGGGIIIIGIIIIIGHIIIGGIIIII@GGDEEGEGIIIDIIBFGHIGCFHGC=;C@AEEEHHCFCE;BB@BEC;?CCCCCDCBC:5=<#
@4P8
GGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTN
+
?8@D7@22ADBF?FGEB2<FEHHFEE@GE;3?D;?GEIF6@FEB?BCC=;CCFC@C@EE?EF>@;?7.76;;>>A>A@BB;;;>A>ABA>9A?=7295<3#
@4P9
GGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGN
+
@<;BDD?DAFAAF<++A2CF@:AFGFEGI>41C:C<@?B:D?B9BFBFB8?BFD;<16=FEIFCCEA(45;?B6?'3;@A;:AAB58(5>9?BB9:9>>2#
@4PA
CTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTN
+
CC@FFFFFHHGHHGHJJIJJIJHGIIIIGIJIJJHHJJJJJJJJFIGEHIJJIJHGGIHGIJIIGIGIJJJHGEC?EBDFDFFFEFCEECEDDDDCDFAD#
@4PB
GGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
B@@FFFFFHHHCFIIJJGGIJJJJJIJJJFHHBGHGHIJJJJJIJIJJJJFHIJIJJJJJJJHHHFFFFFCDDDDDDDEEDDDDDDDDDBBDCCCDCC@
@4PC
CTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCN
+
@@CFDDDDFHHDDHAFHGIJGJJJIJHIIHFC?GEIEG>AGEGHIIHGGIJGG@DEHHFFFD@DF@CCCBBDDDDDDDDDDBB<B059<@B?BBDDD?<A#
@4PD
CCCAAGAGTGAAACTCCATCTCAAAAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIJJJJHHHHHFFDDDEDDDDDDDDDDDDDBDDDDEEEDEECDEEEDBDDDDDDC#
@4PE
CCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTG
+
@@CFFFFFHHFGHGIGIIGCFDHIJGHGHEHIGB>DGIHGIIGJJIIIIJIHCFBFHIIHIEGIIFGGIDEHCHHHDFFFFCECACECDDBBDBDDDCD
@4PF
CGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
?@<DFDDA<FDFAGGG@FHBGICHEFDHEIIG@HIIEFFGHGH@9BFH<FDD9DGB>FGG4=?CCD:;?AAD@6>C5>ACACCC<>5>?:@@@:A@@<
@4PG
CTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCN
+
CCCFFFFFHHHHHJJIJJJJIJJJJFHIGIIJJJJIJJJJJJJJJJJIJJJJJJJJIJJJJJHGHHHHHFFFFFFFEEEEDDDDDDDDDDDDDDDDDDDD#
@4PH
ATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGN
+
@CCFFFFFGCFHHIHIJJHDHHIHHIJIJIEGGIIJIIIIHIJIIJJFIIIGHHIIJJJJHHHB?@BEFCCCEEECDCDCCDCCA?C3>@CAAC<BDDDD#
@4PI
GGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCN
+
@@@DDDDDHHFHFGGGIGHIJJIIIJJIIII>FBGHGHJIEIGIIIGIJJJIJJJAFH5@@AHC=AA@BEEFFECDCC@CDC;CCC@CBDACDCCACCDD#
@4PJ
GGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTN
+
C@@FFFFFHHHHHJIJJJJJIJJJJJDDDDDDDDDDCDDEDEEEDDDDCCDDBDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDACCBCCC#
@4PK
CGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCA
+
@@CDFFFDFDFDDGHEIHHHIGEHIGBHEAHEHGGIIHGIIIIIIICGFHHIDEGEHGGIJGIGCDCHGHCDH;E@;EH>EFHE@CEEFE@CCE>3>>A
@4PL
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
@@@BBDFAHDFDDGHGEHH@FB8FFHIHHBD:?BFFH>?BFDGBDGHIIGHIIIGGHEEHGGFFBDFFEBA@;<=A9AACACACA;@ACC(<CCACC:?A#
@4PM
GCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGGGGTTGATGGN
+
CCCFFFFFHHHHHJIIIJIJJIIIGIJJJIJIJJIGJJIDBD6?CDDCCCDCCCCDCDCC?BC@@CDDECCDDDDCDCCCDDDBBBDDACDDDBDDCCCD#
@4PN
TCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTN
+
CCCFFFFFHHGHHJIHGIIJIJIIFHHIIIJJIIJIFHDFGH?DGGHHIJIHIJGHGIJIJIJIDIJIJIDHJJIGGHFGFEFDEFEEEEDEDDCACCCC#
@4PO
CGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCC
+
CCCFFFFFHHHHHJJGHIJJJJJJJJJJJJJJFHIJJJJJJJJJIJJJJJJJJJJJJJJJJJIIJJIJJJJJJHHHHHHHFFFFFFEEEEEEDDDDDDD
@4PP
CCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGA
+
@CCFFFFFHHHHHJIJJJJJJJIFGGIJIIGIIJJJJJJIIIIIJJIJJJHHJFHHFFDDEDDDDDDDDEDDD@CDDDDDDEDEDDDDDDDDDDBDDDD
@4PQ
CTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGN
+
@<;DADDDDFDCA?EBFGIICBECEHGICDGIEGHI?FE@DG@?D?BAFGHDGBFGGG5/;:AACDBECB>CCC;?BCC?9AB?<ABB<@A@A@A3>:9?#
@4PR
CAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCN
+
CCCFFFF=CFFHDGI<EGHHIJIGIIHFHGIFHIIGEGIIIGIIJJIEAFIIEHIIIGHEHHEHFFFF?BCEDCD;BCCDDDCDDDCDDDC@CDDEDDDC#
@4PS
CTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJ=FHIJHHHFFFFEEEEEDDDDDDDDEDDDDDDDDEDDDDD#
@4PT
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATN
+
@CCFFFFFHHHFHIJIJJJJJIJJJJJJIJIJJJJIJJIJIJJJIJJI7@AAGGGGHHHFFFDCEEEECDDDDDDDBD?=BDDDDDDDDDDDDDDDDDDC#
@4PU
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATN
+
@@@D?DDDGGGDHIIIGHIIIJ?FECFBFGDHHFAHCGCGII@GGGIJDG=AHHFHHEDFE@6>>CCCABDDDDDEFDCCCCDDCCDBCDD>C@<:@C:C#
@4PV
ACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCN
+
C@CFFDDDFHHAHIJJJIIHDGEIJIGIIIJJIJJIFGIHEHGIIJJEGGGII?CEEEFFFFEED@CD@DBDDDEDDDDCACDBDBDBBDDCCDDDDDCC#
@4PW
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
BCCFFFDFHGGHHJIHIGJJJJIGJJIIJJIIGIJGHGGGGIIJIIIIJGGIJIGEGIJIFEGIIIHGFHBDFFEDEECCCCDDDDB8;@D<CDCDCC@C#
@4PX
CAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAAC
+
CC@FFFDFHHFDFGDHHIIGEEGHHGEHIHIIGHEHGGIGHCHHHGDDGIEHJIIIHGHGIJJJIIHGIHJIJJJIFHHCEHFFFC@BCFCECDEDDCC
@4PY
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@CBFFFFFHHHGHJJJJJHJFHIJJJJJJJIJJJJHIIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJHHHFDDDBDDDDDCDCCDDDDEEDDDDCDDD
@4PZ
CCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATN
+
CCCFFFFFHHHHHJJJJJJJJJJIJJIJJJJIIJIJJJIJJJIJJJJJJJIJJJJIGIGIJJJJJJJGIIIIGIJIHHHFFFFEEE>CCFDDDCEFEEEE#
@4Q0
GCCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTG
+
@?@DDDDDFB<2CG@G@:AI?<?2@C?C:?91)??80@DDG?9B*BF88--'--7==A?E/=?B9?=35;3?5<>@@B9@:(4+43(+4>>44>>+:8
@4Q1
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCFFDFDDHFGHIJHIJIJJJIHHFHHIJJJDGIIHHHIIFHGHIJJJJJIHHHHGFFFFFEEDEEDDDCCDDDDDDDDCDDEDDDDDDDDCDDDEDDD#
@4Q2
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
@@<DFF:ACCFHFG@GFFCHIGIEHGICCBE?DDHCG@BBDG?DEFHFE8CGG@FGGIIIGGHG8??@@CEB@C?;@CCCAABB?BA::@A>>CCDDCCC#
@4Q3
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATN
+
CCCFFFFFHHHHHJCGHIHIJJAGHIJJEIJJJGHIJJHIJJJJIJJJIJJJJJJEGHIHHHHHFF@DFEEDEDDDDDDDDDCDDEEEDDDDDDDDDEDD#
@4Q4
CTGGCATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTN
+
CCCFFFFFHHHHHJJJIIJJJJJJIJJJIJJIJIJJJJIJJJJJJJJJJJJIJJIDGIGHJJGIJJJJJIHHHHHHFFFFDDDDDBDD<>>CEDDDDDDD#
@4Q5
GCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCN
+
CCCFFFFFHHHHHGHGGJIIJJJJJJJGHHGIGGHIJGJIIJJJGIGHIIJIIHIJJJJIJJJ=EHEEFBC@CEECDDDCDCCD58?;ACCDDDDDCDCD#
@4Q6
TTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCTTCTTCTGTCTCTCCTCGTCCTCCATGGCCTCTGCAAGGAAGGCAGGGGAAAACN
+
@@@DDDDD?AD?DGHGGBFCGIGIGIIHIGIEGGEEHGAHGGGGHIIEHIIIGC@E;EHEE;CBDEECCC3@CC@C@?>CCCCCBBCBBB?BBBB@BBC>#
@4Q7
CTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCT
+
CCCFFFFFHHHHHIJJIIJJJJHIHJGJJIJGEIIJJIGGGIIIJJJJJDIIJJJJGIJJIEHIGHIGIJJJJJJIHIIFHEEGFDEDEEECEDDCCDC
@4Q8
CATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
@@CFBDDDFFDFBAEHGIIHGEEHGIJ?CFFGDG?DBDGIJJIIIGIGFDGGIHIJCHDBDDADDCDDDDDDDCDDCDBDCAC9599B>?CCCDDDCAC
@4Q9
GTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTN
+
;??D?;A:=CBD<22ACEEF:+AB:<+2<@3?9;D<3?<9D<D@?B?4BD@DDD@:BB=8)==C8@)7@)@))?==3.7;>?@7@@@A@>>>=;'8;5&3#
@4QA
GTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGN
+
@BCFFFFFFHHGHGGIIIJGHIIJIGHEHHIIJIIJGHIJJJIIJIIIJIJIDGGGACHEFFFFFCCEC@CCDDDDDDDDDDDEDEEDDDCCDDDDBDDD#
@4QB
GAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCA
+
@@@DDDEFGFBHHJIJJIJJHIJJJJEIIIJJGIGHIEGIHJJJJJGIIJGIIIIIIHIEHHCHHDHGCGAFHIIGIIDDC?EHHHHFBEECCE@CEED
@4QC
GGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGA
+
@CCFFFFFBFHD<B<EHIEIBHEFHHGGHFG<GGGIIDFGHHHHBGHFFGDHHCHHFHHEGEGGGIGIGGGGAHIIIGACHHEEHCDF;ACCCCCEEDC
@4QD
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
B@@FFFFFHHHGHJIJIEIJIIJJJGEIJIJIJCEGIGIJIIIJJJJJIJJJIIIIIJGCEHHFFF39@BCACDCDDDDDDDDDDDDDCCDDDBBDBDDD#
@4QE
CGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTG
+
CCCFFFFFHHHHHGHHIJJJJJJJJJJGHIJIJIJJJJJJJJJJJJJJIJJJJGIIIIGIIFHIIJJJIHHHG?EEFCDDD;ABDDDDDCDD@BDDDDD
@4QF
AGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCN
+
CCCFFFFFHHHHHJJJIJJIJJJJJJIJIIJJJJJJJJJIIJJJJIIJJJJJJJJHHHHHHFFFFFFDEEEEDEDDDDDDDDDACCB?BDDDEEDDDEDE#
@4QG
TTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCN
+
1?<DAD:BFADBDFFEEEFC:,3ACHCCFF>HC9DC9F9*:C99*?DF<?B<@B:?<@FG*9?@/?@DCFFB<CFFG>).=;7=CACECE)=CEBD;;;6#
@4QH
CCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGN
+
@@CFDBDFHHGHHIIIJJJJJJIJBHHGJIGIJIIIGIJFIJJIIIGGFFE@CECECDDDDCCCDCCDDDCBDCDDDDDDCCCDDDDDCA@BBBDDDDDD#
@4QI
CTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJJJIIJJJJJIJJJJJJJJJJJJJJJJJJJGIJJHHHHF;BDCDDBDDDDDCDDDDDCCD:?B9CDD#
@4QJ
TGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTN
+
:?<B:A@:<:AD<EE<BA<CFEDE+999:8CDDCADE?DD>6@A2=CD;>7(;?@ADA>A;;@;AAAAAAA;-5,5>3:5>>,:>AA::AA80;5;98(+#
@4QK
TCCAGGACTGCAACTCGGTTTTCGAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCN
+
?;+:=;DBDBCADED>;AFF1C4):CED6B<D4:DEEEIDDDEA??DBCDC@CCIAA<8AD)?;?D@//==>AAAAAAAAA?<>35;(:4:>AAADDDD3#
@4QL
AGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIIJIJJJIIJJJJJJJJGIIJJJJIJJIIIJJIIIJIIIIHHGFFFFFFEEDDEDDDDDBDDDDDD#
@4QM
TTTTTTTTATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGN
+
?@?DDA?DFDDFDAGC<GD?F@FB<99BG@B9<;;FH;=FA?=;1=@=?;A7?7)..63;(;A;CCC?=?2(<(5@CCC@C3@:(48::4+(433?@:A:#
@4QN
GCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCC
+
???D?D?;=2C2CAA::;+3<CFAE8:E4:111))0)&)&)+8+>3<++9(+993(:3(+3>8+250<1++>:>:>A3+++:AA>>>4>:5))00((48
@4QO
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
CCCFFFFFGHHHGJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJ@BHFBEEEEEDCDDDDDDDDDDDDDDDDDDDDDDCDD#
@4QP
GGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTN
+
@@@DDDDDBB?FFFEHDGGE@?F=@FHHIIIIICHG?CG?C?@G@FHG@DHCDHGEE>AEE>DDEBCC@ABCC?CACCCACCAC?ACC@CCCCCCD>>CC#
@4QQ
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCCGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CC@DFFDDCDFFFHIIGEHIGDFACHH9EEHGIHEGEBGFCG?BHGD=CCBFHCHGGHEAEFFD9<=CDCCB?CD3@CCCCB@>@BDDDDDCCC@C@CC@#
@4QR
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCA
+
@@?DABDDHHFFHJFGIIIIGFHGEIIJ<EGHGGHBE@?GHIJJIIICHGIGIIGHGHGHHHBBD?@CCDE@CDD@8@BDDDDDDCCDDCCDDBBD>@B
@4QS
GTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTN
+
C@@FFFFFHHHFHIGIJGGIGJGIIJIJJJJGHGIGIJJGJJHGFIIJHJJIGIJHGIJJJIGHIGGGEGGEHIGEIIJJAGGIIEHHFHEEFFFFFFFE#
@4QT
ATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTTAGCTTTGAAATTTCC
+
:@???AADCF<FFF<B?F:CCEH<?B@HCHIAFCCGIFFIEGBGEB9B??BDGG@GBDFI@DAFBBCC8=8=CAFFEDFC>@DA?3)7=?;@BDDBC>;
@4QU
TTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGN
+
CCCFFFFFGHHHHJJIJGHJJJGIJJJGJJJJIIJJJJJJJJIIJHIIJJIJJHIHHJJJJIFGIHIIIIGFHFFDDDD&9@DDDDDDDDDDDD>CCCDD#
@4QV
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCCCTCCN
+
?=?;:DBD2=2C2A2<AAC<<F3AC3<EA8??DDC<1:?*:9*:??8B?B?<D;(88B1-5@=)).7A3?C;@7,=@>;?:5555>>>::>3:>A(59<>#
@4QW
TGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAG
+
?@@DADDDHHH?DF;A?GH=;?C<FBF@GEBHGH@FGGHHIGBGGIIG<B?B?FHGGGEHGGHCEEGHGCEEAHE?ACCCCACCCC(::?@CCCA:C@
@4QX
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
@C@FFFFFFDHHBEFFGGIIIGGEFCEGIIIGGIIIIGIIDHGHIIIGIIIIIIGGHHEGIECEGIGDGFHE?=BFDCCDDCDCDCAACCBDACDDC
@4QY
GGAGGAGAAGCAGGAGCTGTCGGGAAGATCAGAAGCCAGTCATGGATGACCAGCGCGACCTTATCTCCAACAATGAGCAACTGCCCATGCTGGGCCGGCGN
+
@@@DAAD;FAA<A;<2:<<<A<F:F?F?:?B?D990900//*9D@8C=8=F7..@<8599>5AC:;>@>>><@C:CCA:<8>CC?8>9C>3@@<?<5..9#
@4QZ
CTTTGCTTTTCAATCTCTTCATTTAACTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTN
+
=;+4A?DAD8CCFFG@GBEF@EF@H,33AH<A+22AF911:91:*:FG*)009D?BB**989?B4)8C)=<)8FACE;)>=@;7C@E)=6;?B>@9@@36#
@4R0
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
B@@FDFFFHHFHHJJJJJJJJJJIJJIJJJJJJJJIJJJJJJIIJJIJJIJJJJJGHGIIJJICHHGHHFHFEDE@DEFDDB;BDDBDDDECDCCDDDDD#
@4R1
CTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTN
+
CCCFFFFFHHHHHJJJJIIHIIIBGIJJJJJJJJJJIJJJJHJJJJJJJJJJJIJJHHHHHFFFFFFDEEEEDCDEDDDDDDDDDEDDDDDDDDDDDDDD#
@4R2
CTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTN
+
@@@?;DDDAHA1DG>E@FGHIIICDEGEBD@DG?F;BFHCAEEGIHIII8BHEF@C?;@;>@?CC@C;@=BCCCCCCCB?BB><?CCCCCCBB5<B>ACC#
@4R3
TTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAA
+
CCCFFFFFHHHHHJJHIJJJJHJIJJJJJJJJIJJJJJJJJJIIIJIJJIIJJJJJJJJHDGIIJIJIHIJJJIJJIIIIJJIJJJHHHHFFFFFFEEE
@4R4
AGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTN
+
?@:BDFFFGHHHHHIBEGIIIIIIFHGIIIIIEDHIIIIIIIGIFEGHIIIEHGGGEE@CED?DFCD>C@CEEDDDD5>ADEDDDDDDDDDCCCDDDCB?#
@4R5
TTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGN
+
@@@DFFFFFFHHHIIIIIIEFBFGGIIIFGIGDCGHEGGGFHGGGFGIHEHIGIIGBAEEEBCEEDDD@DDCDB<CCDCCDDCCBBDDDDEDEDDAB<<@#
@4R6
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
<@<DDDDFFHBHHGIIGE9?FGBAGFEFDFF?DHGGIEEGIG;?CGCHIJIIJJIHD9CC7AE@BDA@:8>ACD>@?BB??ACDCDC>@CC>ABB>B@B?#
@4R7
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BBBFFFFFHHHHHJJJJJBGIJGHJJJJJHIJJJJJJIJJJJJJJJJJIJJJJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDDDDDDDDDDD
@4R8
TTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTN
+
?<?DDDAB<CDD?CD9+)3:)<AEDEED7DCD@9??<?BDD9DDEC@<A<A<?@@@?>AAAA???:77;)&5((98:8>A>+>>::(<AAA?AAAA?3>;#
@4R9
CTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCN
+
@@CDDEFDFDHHDGIGIIIIIFBB?BGGGIGHBAFHIGIIIGGGGHGGDHIB>BEAECH?CD?AC??CC=ACDCDDCDDCD@AB?8??@BDDDCDCCCDD#
@4RA
CTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTN
+
@CCFFFFFHHHHGJIJJIHIFIJIJGJJJJJJJJGIJJJGIIJJJJJJJJJJJJJJJJIIHIIIHIJJHIIJHGIJIIIJJJHIJIHHHHGHHFFBEFDF#
@4RB
ATTTCATTACACTGTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGA
+
CCCFFFFFHHHHHJHIJJJJJJJJJJJJJJJJJJJJJJJHIIJJJJJJJJJJJJJJJJJJIJJJJJJJJJIJJJJIJJHHHHHFDDDDDDDDDDDDDD
@4RC
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJJIIJIHIJJJJJIJIJJJIJJEIHGHHGFEFDFFFDDD8?DDBDDDEDDCCDDBDD#
@4RD
TCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGA
+
@@@DDDDDDHHHHHEBABGGH=GEBGAD9CFC<CGAAGEHCEFBB>;D981:FEGGHGE@EA@G;)?;A=@(?@:>6>CCA>@CAA=BCBCCC??A9<
@4RE
CCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGN
+
CCCFFFDFHHHHGJJIJIIJGHIJJIJIJJJJJJJJIJIIJIIIIJJJJJIIJJJIFHHHHHCFFFEEEEEEDDDDDDDDDDDCDDDD9BD>CCDCCDBB#
@4RF
TCCTGCTTCCAGCATTGCAGCATCAGGCGGTACATCTCCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTN
+
<?@DDDD>C3DD?GFB><E<<CADB33?:8)?DDD<B?BGHAGIBG;8FE>=E>@EEAE=;@@@DCCC<,96<?@B8<>CCDC@A>8A:9ACC@BCBB9@#
@4RG
TGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
B@BDFFFFHGFHHGIJJIJIJIIIIGIIJJIJIIJJJHIJIJJHJJJIJIHIIIJJIJJJIJJJJJJHHHHFFFFDDDEECEDDDDDDDDDCDDD>CC
@4RH
CTCGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
<@@DFFFDF?HDDGGGIEEDHAG@GF>CEHIG:DFHGBHBCGH@FGHCHIGHHFFD@@AEAAECCAACCCCCCBCCCCC@CC@CCCCCCAACCACCDCC>#
@4RI
GTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCN
+
C@@DFFFFFHHHHJDGGIJIJJJJIJJJJIDFGEGHHI<FHGIHGEIIJIJIGHIIJJJJIJIF8>?CEDDDDDDCDDCDDDDDDDDDDDDDCDCCDDDC#
@4RJ
GGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATN
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJJJJHHHFFFFFEEEEEEEDDDDBDDDDDDDDDDDDDDDDDDDDDEE#
@4RK
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
BCCDFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFEDEEEDDDDDDDDDEDDDD5>BD<CDD#
@4RL
TTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCN
+
CCCFFFFFHHGHHJJJJJJJJJJJJIJJJIJJJJJJJJIJJJJJJJJJIJJJJJJJIJJIJJJJJJJHHHHHHHFFFFFFFEEDD@DDDDDDDDDDDDDD#
@4RM
CTGCCTAGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTN
+
@@@FDFBD<FFHDEHGIIIHA3AACGHBEHGGIIGF@FGHHCEGI??;9BFHGGCFHGGHIIIEEACGHEAAAABBECBDC>AAAB==?CCCAC((95:>#
@4RN
GTCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCN
+
CCCFFFFFHHHHHIIHIJJJJJJJJIJJJJGIJJJJJFGIHIFHJJJJGIJJJJJHHHHHFFFFFFEDDEEDDDDDDDDDDDDDDDEDDDDDDDDEDDDD#
@4RO
CAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCN
+
@@@DDDDDHHHHB@CFG:?HGHI@@EHIAA6AAACC??C?@CCC>CCB:A<@CCECDDDCCC?BB>AA@@CC@BBBCCC>0?@4?CA@A@B<CBCCC@C<#
@4RP
GTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGA
+
@@@?DDDDHAHFFGIIIHGGAHGGCFHBGHGGIDGIIGHGIHEGIIIIIIIIAGEHFHFFFFFFCBBBBBBCCBCCCCCADCCCB?BBB>BCCCCCCCC
@4RQ
CCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTC
+
@CCFFFFFHHHGHIJHGJJJJIJJIJJJHIJJIJJIGGGJJJGIIIIJIJJIIIIIIIJJJJJJGIJGHIHGIJIJJJJHHHGGGGFEFFFFFDEDDE
@4RR
CTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGA
+
@?@DDDDDHD<;D;CEH)<CF@EHG6:;C94BBD9?DGB)?BACF;5@EECEI;?AEEH5?B7>C;>>5>>CCCCCCBB<8-?89@?290:@C?>::4<
@4RS
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
CCCFFFFDHHHHHIJIJIJJJICHHJJIJJJJJJJIEBFHHGGHIGGEIGIIFHIIIIIIJHJJGHIGJJIJJJGHHGHHFF;BB?CDD;ACEDCDDDDD#
@4RT
CTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTN
+
?@<DFFDDBBBCDGGGBHH@?IGGBBHFGG?GHHGHIIIEHAHIIIGIGDHEICDGEFFGHIIHIIGEEDHGII@EEHFEDC?C@DCCEC@CCCC@>@BC#
@4RU
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
@@<DFDFEHHDHHFHHJGGIICFHIGHHHIJIIJJIE?DHGFGIHGIGIJJIHIICEHIIIJJJIEHIGJIIJAEHEHHHFF>>A@CCCCCCDDDDDDED#
@4RV
CTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGN
+
;?@DDDDDHHHACFBHGCCGCEGGDHG@<?BFGHIBFGIIGG@DAGE@FGGGA-;=5?@?CEECC:??CCCCC::A@@>C?BBB>B@3>>>A:@A@@CCA#
@4RW
GGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTN
+
@C?FFDDDFHFDF@HDAFAEAFBGHIIIEHIEGDFDHFEH@FGIGBCBCC@GEIIIGFGGDDDE=AC>B@B@B@ACEECECCCCCCC:>BCCCACCCCDC#
@4RX
CAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATN
+
CCCFFFFFHHHHHJJJJJJJGIIIJJIJJJIJJJJJJIJJJGHGIGIJIJJJJJIIJJHIJIIJIJJJIIJJJJJGIIGHGHHGHFFFDFEEEFEEEEDD#
@4RY
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGN
+
@C@FFFFFDDFBDFGIIBHGGHFHEGGGIIJHIGGB?FDBDDFGI@FEDHGIJIIEHGGJJG@GGHFCEBBDEFDACEEACCBB=BDCDCDCC>>ACCDD#
@4RZ
CCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACN
+
CCCFFFFDHFHFHHGHIJJJEHIJJJJJI?EHIJJJIJIIBGHIIIGIJJJJJIJGHGBDEFFFEECEEEDDDDDDDEEDEDDDDD?DDDDEEEDDDDCD#
@4S0
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
@CCDDFFEHHHHFIIJJIJGIJIGIGGIJIHGIJIJJIJIJJJJJIJGGIJJJGEHIJJJJIH59>AC@CCDABDDDDDDDDDDDDDDCCBB@>BBDDDD#
@4S1
GTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGACACCAAAAGACCATACATCACTTTGCGTGN
+
@@CFFFFFHGHHHJJJJIJJJJJJJJIIJJGIJJJJJHHJJIIJJJJJJJJJJHHHFFFFFEEEDDDDDDDDDDDDDDDDBCDDDDDDECCCDDDDDD<@#
@4S2
CTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATN
+
CCCFFFFFHHHHHJJHHIJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJHFHHIJJJJJJJJJJJJJHHHHHHFEEFEDEEEDCDDDDDDDDDDDDDDDDD#
@4S3
GGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATN
+
@@CBDDFFHHHHHJJJIJJJJJIJGHIIJIJJGIII:AGGIGIJJIJHHHHHHEDEFFEDDDDDCCCDDDDDDDDDDC+4@CDDDDCCD<2?BDDBBDBD#
@4S4
TCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJJJJJJJJJJJ@GHFIJJJIJJJJJJJJJHHHHHHFFFFFDDDDDDDDDDDDCDDDDDDDDDDEEEEDDDDDD
@4S5
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
@@@FFDDDHHFDHJJJJIIIJGIIIJJEIGGHIEHGIGIJIIIIIJIJ9CFHGIEHCHHIFFEHF/=@BCCCDDDDD8?BCDDCACDC@CCDBBDBB<?C#
@4S6
CTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATN
+
?@@B?DDDBFA;F<AGG+AFGGGFC@FGG<BDA@<BDGI9DGEEHB<DAGGGEHII7@@.6CCC;?EBEECDDB1;A;;C@CCCC::?C>::>@>A@5((#
@4S7
GCCTGCTGCATCTGCTGATGGTGGTGATGATGGTGCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACG
+
CCCFFFFFHHGHHJJJJHJJJEHIGHIIJIJJJFHIJJJJJJJJJJIIJJJIJJIIJJJJJIJJHHHHHFFFFFEEDECDDDCCDBBDBDDDDCDCBB
@4S8
CTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCAGGTCTCGGTGCACAAAGTGCTN
+
@@@DDDFFHHHGFIIJGGIJIIGEHIGEHGHIGDFDHIJIIIHIGHIIIIEIIJIGGHGIGIHGGGFFFFFFE>ACADDDDCDCDDDDDDDCCDDCCCDC#
@4S9
GGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGATGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
?771A?BD>FAF<CG<:+<CCFHI<EFHFBFE?FB94DB9?BFF)8=(=@@AE;;=C>?:?3@BB7?AA6>AC;=;ABBB;@A?<98<ABBDBBBBB=4
@4SA
CCCATACATCTCATCCAGCTCTGCCCGGAGTTGATATAACTTTCTTTGTGTTTCTTGATCCATTCGTTGTACTATATCAGGTTCGAACTGGTTGCCTTT
+
???1A3?DD8:C?BE><:++<3A:<A)))1CD**:**:***:D*??DE98BDB)8B))).)8)>@4..7-).))=7))77)..),(6;=:>((,(,:>3
@4SB
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CCCFFFFFHFHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJJJAEFDEEEEEDDDDDDDDDDDDDDDDDDDDDDDBDDDDDDDDD#
@4SC
CTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCN
+
CCCFFFFFHHHHGJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJHHIIJJJJJJJJIJIJIIJJJJJJJIFIIHGHGHHFFFFFFEEDEEEEDED#
@4SD
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTTCGACATATGCAAAATCTCTGGGATCCTGN
+
??8ABDDA<DDC4<B>D3A3:3+ABEEB;:CEB<D9C41?:?:?BBB@DB<3?*96;;7;74.2@)().7))).(59'6;(66>>?>5>>>>>?(555>>#
@4SE
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
@@@BDDDDFHHBCEFFHGIJJIJIGGAEHIGGGEGHIIEIJGGHIJIGIGGHJIEGHDH7CCG@@AC=CCAEDFD>DCEEDEDCACD>2<B:<AB(5<08#
@4SF
GCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJDFGIIJJJJIJJJJJJHHHHFFFFFFEEEEEEDDEDDDDDDDDDDDDDDDDDDD#
@4SG
TGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGG
+
@@@FDDDFHHHDHIIGEGDHII@GEHEGHGFGGEFGGFGGGEGGIIII=FEIGGHHHGH;@DDFFEECD?BBDCCDDDD@CCCCCC@DD@<BB@<BDDD
@4SH
ATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATN
+
CCCFFFFFHHHHHIJJJIHHJJJJGJJJJJJIIJJJJJJJJJJJJJGIIIJJHHHHHHHFFFEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDD#
@4SI
ATTCAATTGCCATCCATTTAACTGGAATCCGACCCTGGCTCCTCTTCACGTAGGAATCCTCTTCATAAACATCTCGGGACAAGCCGAAATCCGAAATCTTN
+
=@BAADDFHHHGFIIJJJJJIJIIJJJIIJHGFHICEHIGHGIFGGIJJJGIIGGGIIJJIGGIIIHFHHHHFEFFFDBDBBA?BBBDDDDDDDBDBCCC#
@4SJ
ATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTN
+
@C?DDDDFHFFHDEHGIFECDFFIIGIIGGGCHJIIIEGIIEGGIJGIJJIHIEHIIIGGEDHGCHIIDGGGIGGECECEEEHHCHFDDD@C;AABBDDC#
@4SK
CCTCGCTCTCCAGCGCTGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATN
+
@@@DDFDFHGHHGJIEGJJJJJIIIIJJJJBGFHHIIJEIFJJBEHFDFDCECEDDDCD@CCCCBACD@BDBCDDDDDDDBDDDDDDD?<ADDD@BBBDD#
@4SL
CGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCA
+
CCCFFFFFFHHHHJJJJJJJJIJJJJJJJJJJJJJJJJJJIIJJJJJIJJIJIJJHHHHHFC>BDDDBBBDDDDDCCDEDDDCCDBDDDBDDDD@DDCC
@4SM
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
?@8BDADDHHFFHII@GGGEGICGGHIIHIGIIIIIIIII?BDFHIGGHGIIIGIDIHGEDHEFHEE=BDFFEECECBDBD@DDD:@C@A@A@CD9:4
@4SN
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJJJJJIIJJJJJJJIIJJJJJJJJJJIIJIJJJJJJGHHHHFFFFFFDEEEEEDDDDDDDEEEEDDDDDDD
@4SO
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATN
+
@@CFFFFFHHHHHIJJJJJHHIJJJJJJJJJIJJJJJJJJJJJGHJIIJHHJHJIJJJJHHHHF@DDFFEEDEEEDDDDCDDDDDDDDDDEDDDCDDDED#
@4SP
CTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAGCTGCCTGGGGCCCTTTTCAAACATN
+
1?<D738=8:@<D<A,A:+ACA;EGEDDD9B<:?C<?FCE@*0*??<BFFFB)8=<;@((66(=)=?7=7;7??;).6;(6;>=@6'88?<A>>@>:+++#
@4SQ
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@?@DDDDDFHDDH<CCC<FHIIHCDEDF<C;FGEHDFDDFHIB:BFGEDDHGED@<9B=CFGHHCHIIADEC1.5?=BEC;>>>;;C>@D@;;55>89?9#
@4SR
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
CCCFFFDFHHHHHJJJJJJJJIJJJIJJJJJJJIJJHJJJJJJJJJJJJJJJJJJIJIJJJJJJJJFHIHHHHHHFFFFFFFEEEEECDDDDDDDDDDD@#
@4SS
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
;8+4=:DB?<A??CFFE@@AECEH@EEGHGH?DGGHIG<BD>93BFHBF8=;8=@FEIAADGG;?7?EEEDE3@?@;>>5;>;5;;@@ABBBBB<B0:?>#
@4ST
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@8ADDFFBHFHHGIDGIIIIJGIGIJHIIIGJJJJJGCGEGEHIIHEHAGIGHIIJIIHJJIJHIJFFEFHEDFECEEB>A@>,5?BACCDDDDBAA
@4SU
GAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCN
+
?@8DDDDDDFAFHGG?DFIGGFHFEFGCDHHIIGGEGGH<FHEFC;CFHIIIIIEGGGIGIIFHHFHHCBEECA;ACBB?B?@??BBCCDCCCCBBBBB<#
@4SV
CATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCN
+
CCCFFFFFHHHHHJJJJJJJIIJIIJJJJJJJJIIJJJJJJJJJJJHIJJJJJIIJIJJJHJJJJHHHHFFFFFFEEEEEDDBDDDDCDDCACDDDDDDD#
@4SW
GCAGGTTGGTGAGCAGCTCGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGGTGGGATCCTTCAGGGCCTTCACAGCCACAAGCATCTTGTCCTTGGTN
+
=??D;2:=82A?DGBA?AFGIIEIFFFGFIIIFFIE@BA9?B((-<@@EE@@?8CD<9@CBB@5>>>:@?8?A:A@>BB82<@<28<BABABBBBBB>34#
@4SX
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATN
+
@@@DDDD?FFFHFGF@<E<7FFGGAF@FHIGGIGI:BBFIA<BFHFGGEH;CCDG@E8;E>?EC?D?B@ACCCCCB@?@CCC:>5>@DDCC@CCC:>ACC#
@4SY
GCTCAGGCTCTGCAGCCACATCCGACCGAGTCGTCCATGTACAAGTACCCTTCTGACATCTCCTACATGCCTTCCTACCATGCCCACCAGCAGAAGGTA
+
:?1=BDDFHHHHHJJJIJIJIJJJJJIIIJFGHHHIJJJHIJJIJIIIJJJIIFHHHGHHFFFFEEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDCC
@4SZ
ACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCC
+
@@<ADAB?DFDHFIIHIIGEA?FGHIG3BFDFF>GGHGGIBCGEGEGG5ACAC7=?AE@@>BEE@B>@C;>DDDCC>>C>>A<?CC8?C@<CCCA4?C
@4T0
GTTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATN
+
CC@FFFFFGFFGDGHIGIGIIIIIGIIJJJJEII@HEHHGGIGGFEGIIGCHIGCHGGGIIGGIHGGCCEE?D79<BB@'5>CCC@CCCCCC@C(88&::#
@4T1
GGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGN
+
@@@DDFFDDH@FAHIJJDIGJECGCG?BDHGIIJDFGIGGJI98FDDHHGFFDDDDDDDD3><9@CCDCCB?)9?CCDDC>@CDEDC@C@CC@@ACB<BD#
@4T2
GCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTN
+
@@@FDDDDH<C?DGFG@EHHEGIIIIB>1EHHGIGHHFDBFHEEGA>?DDHIID=FHGIEHEHFFE>E>B@BBDDAECA@>A?AAA>>>;BBD?BD3950#
@4T3
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
CC@FFFFFHHHHHJJJJJIJJIGHJJIJJJHHIJJFHJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFFEDDEDDDACDDDDDDEDEDDDDDDDDDDD
@4T4
GGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTN
+
BC1DDFFFHHHFHIJIJJJCGHIIJJJJJJCGHJJHJJJJJJJJJJJJJJJJAFHHIIJJHHHCDFFFFFDDDDDDDDDDFDEEEDDDDDDDDDEDDDEE#
@4T5
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
BB@DFFADFHHFFHIIGIIJJIJIJJJJJIJJJJJJJJGJIJJJJIGIGIIGIJJGIIEGGGIIJJHHHHBFEFDEECEEEEDDDDD,;BB@CDDEDD:C#
@4T6
TTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTN
+
@@@DFFFDHGHGHAFHEGIDGHHIIGIIIIIIIIIIIIIFHIBFHIIIIIGIBHIIGFEFHBDDFDE@CEACCCB=BBB?CCCDECCCCB@BBBCCCCCC#
@4T7
AGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCN
+
@CCFBBDDBCFDDHBEAHA@CFFBF??C?FC*1@?@GIIG??F@FHDBCGE78CAEHHCHHC3?;?<=@C@CCCC>CBB,3<)::@4>485<??CCC:A>#
@4T8
GTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAA
+
CCCFFFFFHHHHHJJJIJJJJIJJJJJJJJJIIJJJIJJJJJJJJJJJJIJJJJIJIIIJJJJJJJJIFHIHHIIGHHFFFFECEEEEEDDDDDDDEED
@4T9
GAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCC
+
?;?A;;DB:C8?FAHGHIGGIG@ECACAE8FC?DDDGGDBEH>B<*9B;)?DBGHGH-=DG>EACHAC(;@@@CC>>C@BBCBBC@CBBB85?CCCC?
@4TA
GGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACN
+
@@@?DDFFFHHDFIIIIIIIIGIIIIFCCEGGIIIIIHGGFGIICHC9DBFEIIIIIIIIIGG@@FG<DHDHEE<<<?>@@ACCACDDBB35<?CC9?CC#
@4TB
ATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAAC
+
@CCDFFFFFHFHHJGIJJGIIJJIIGHHGIGIIGIGIHGIJJJIIJIGHHBGIGIJGGHEDGIIJJJJIEIJJJJGGIJJJJJGHIII@HHHGGFEFFF
@4TC
CTGAGCTGCATAGGAGGCCTGGGTGGTGGGGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGN
+
@@CFFFFFGHHHFIGHJJHIJJJAEFGHI0BBGIE<FGIDHGHJ=CH@GIGIJIIJHGHHDFEFFFECCCEDDB@BBDDDDDAABBCBACDECD:>BDDD#
@4TD
CTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACT
+
CCCFFFFFHHHGHIIJJJIJJJHIJJIIGIIIIJJIJJJEIJJIJJJIJGIIJJJJJJJJJJJJJJJGIGIJJHHHFHFFFEDDEEADDEEECDDDDDD
@4TE
CACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGN
+
@@@FFDEDHGHDHJGGIHIJGHHIJJJIAFHGEGEHHBH6B?GGIGDEGIHCEGIIICGGICHIGEGCCEHHEDBDBDCED@@CDCCCACCBBDDD5?@B#
@4TF
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCFFFFFHHHHHJJHIIJJJJJIJJJJJJJJFHIJIIIIJJJGIJJJJJJJHHHHHFFFFFEEEEEDDDDDDDDDDDDDDDDEDDDDDDDDDDDDEDDD#
@4TG
GACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCN
+
?@<DDADDHB<DCF?AFBHBAHEDEBFF@FGEIIC@@DG?@FHFDF<DFAD;FECCFBG3@@AH:CH:?;BD3>AABC>>CC>((359<<,>A:>AA:::#
@4TH
CCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJIJJHHHHHHFFDDDDDDDDDDDDDDDD
@4TI
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
@C@DFFFFFFDDHGHIIIEHIIIGG@FFFG@G?GHBGEFAE?DEE<CGGBHG?GCEEEEHFF@BDBBC<@DDDDCCCCCC@C@>CDDCDDEDDEAACA>C#
@4TJ
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
;?@DB8DDFBB:DG@G@8C9<FAA?)1C?GDGI8?DBDA@@FF;@F)=CE@D7??B<9=?6>A;;;B?5;@:/=BBBA>:ABA<4:<:@>4>@@B3>AB
@4TK
CCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATN
+
CCCFFFFFHHHHHHIJJJJJGJJJJJJJGHJIJJJJJJJJJJJIIJJJJGIIJJJJJJHGIIJIIJJJJJGGIJHHHHHFFFFFFEDDABDDCDDCCDEE#
@4TL
ATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTN
+
CC@FFFFFHHHHHIHHIJJIJJJEGIIJJGHIJIJJJJJIJIIIJJJJJIJJJHIJJIJJJIJJIIJJEHIIHHGHHF;BBEFEEEDDDDDDDDEDEDDD#
@4TM
GCTCCTTTTACTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATN
+
@@?DDFFFGHGGGCHHIGIGIJGICGHIIJJJJIIJJGHIIIEFHGGIEIJHIEGGIJJJJEIHGHJJJJJJIJJIIIIIH?EEEDFFDFFEDCAECDD9#
@4TN
TTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTN
+
CCCFFFFFHHHHHJIJJJJJIHIJIJJJJIJJIJJJJJJIJJIJJJJJIIIHIJJJJJJJJJJ<FHJJJJJIIIJJIJGHIJIJJIJHHHHHHHFFFEDE#
@4TO
TGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCN
+
?@@ADDDAFHD?FABB2AFBFAAFH3ABHHEAD?@DDCDG@BFG</=C=FA=.@7=;AEH>CC;=?(;;AAA:A@CC@CC((5>ABCBB>@A(:AA4@4>#
@4TP
GTCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCN
+
CCCFFFFFHHHHHJJJJJJJJHHIJJJJJJJJJJIJJJJJJJJJJJHHFFFFEEEDEDDDEED>CDDDFFEFEDDDDDCDDDDDDDEEEDDDDDDDDDDD#
@4TQ
CTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGGATGTAGG
+
;@;?;D8D?BFDFB<?E73:A3A@FABFFB<EA*:):?<G99B7D@(;84@;1C;AE3=C>?B@;>::;>B((5915<B2((,8>4??&8384:@@
@4TR
CTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIFHIJJJJJJJIJJHHH;EEFFFFFFCDDDDDDDEFED#
@4TS
CTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACN
+
@@@DDDDDHB?AFF@EFBH@HEHEH:8DEEEHIIGGHGGHIIE3BF;CHGIEADCCCCCCCCCCCCCCCCACCCCAAACC?BCCCCCCC>CCCC@BBB<B#
@4TT
CTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGTGAGG
+
CCCFFFFFHHHHHJJJJJJIJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJHCEEHFFFFFFEEEEEEDDEEDDDDDDDDDDDDDD
@4TU
GGAGGGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGAAGTGCAGGGGATGN
+
CCCFFFFFHHGHHJJJJJJJJJIJIJJJIJJJJJJDHIJJJJJHIJJ=FHIAEHBCFFFCEDDDDDDCDDDDDDBDDDABBDDDDDDDD:>CCCDDDBDB#
@4TV
GAGGTTTCCTTTTCTTCCGCAAACAGGAGGGGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGN
+
8:?BBB?DFFFFFGEGB<EEFFE;E9)::C):)8;DD??AF=FBCFEEFEFEE'55.;@B@;;>/'8?ABB?+9<AA>>@BA@7<>?B>4++4:<?89>B#
@4TW
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCN
+
::?DBDDD<DAC<CGHIHBD@GCBFDFHHIHFGGIGDEFG?BFGC?GEEGHDG?>B<C@=CFHI@EH@7=?AEEB>(.==C;@=???(9AA>5>>A>>??#
@4TX
TGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTN
+
@@@<DDDDDFFHDEEDGBH@HHDFGEGGGIICHIIIIHIIGGGHGBBC@CC=CFGEHI..=EE@HCDDEEECCECCCBCBBCA@CCCC>>CCD>@C@ACC#
@4TY
TGGGCTTGCTCCTGCCCACCATGCACTTCTCTTGCCCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGCGGCGCCCCCAGCCCCCTGAAGCCCAGGTGN
+
@@@FFDBD?DDFHIFIGIIEGEHHGCGHDGEIIIIGIIIIGHDAEEHGHFI>CGIIIIIGGGHEHIHHHEBEFDDDDBDD>??@DDDBDDDCC@BBBD:@#
@4TZ
CTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTN
+
@@7ADEDDDHFHDGHEHEEFDFDEGFAFH@CGFHIIGHH=BBBGHIIIII@FEHIBB/=@H>FECEAGCHAD;==?CCEDFDDFFAA@C;>355-;5;;>#
@4U0
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGGGGCTN
+
+=?;1BD;C?>DD)++AD@CF;89AE3C::8?0?:??DDD9DEI9?8)8<4=BC)87@@=77@=CDD?CDA;.;7>AA@'3',8:AA(5::>:>:()&50#
@4U1
TGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGN
+
BC<DDEFFHHHHHJJJJJJIJJJJJHIJIIEHIJIIIIGIJJ?FGIDGIH7=CGHIIJJIJAEFHHEFFFFECDEDDDDDDDD;@DCCDDBDDD:ACDDD#
@4U2
ATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTN
+
@@CFFFFFHGHHHJIJJJJJIJJIJJJJJJJGGGHGHIJGGIGHJJJJJJIIJIJIJJJJGJGHGHIIGIJHHHHGGFFFEFFEEEDEEDDDCEFFEDDD#
@4U3
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
C@CFFFFFHHHHHJIJJIIJJJJJIJIJJIJJJJJIJIEGIJGIJJJJJJIJJJJJIJJIGIIIIJHHHHDFFFEFDEDEEEDDDDD,8@D<CCDEDC@C#
@4U4
CTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTN
+
CCCFFFFFHHHHHJJIJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJIJJJJJJIJJIJHHHFHHHFFFFDCDDEDEDDDDD#
@4U5
CTCCATGAACCTTTCTGCCATCTCATAAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCN
+
@<<BDDDDA83DF>CHG9CHIIIIIIIIBHGD@EHHAFGG@FGAHC?FC>G<?9?FGGGCAAGGEECHE=CC@?BD;7>A>ACBC?CC39<<ACC@C@+3#
@4U6
AGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCN
+
CCCFFFFFHHGHHJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJIJIIIIJJJJJFHJJJH=EEFFFDCFEEECCE;?B9@CDEEDDDDDDDDDDCCD#
@4U7
CAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTN
+
CCCFFFFFHHHHHJJJJJJJJJJDDDDDDDDDDDDDEEEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDCCDDDDCDDC#
@4U8
GGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCN
+
C@@FFFFFFF?DCEGEGHHHIIIIIIBD@GEBGHHHGIGFHDACGHGCCGEAGEHHFEED??@@BCEEE>@CCCBBB@@BBCB<@>+8:>ACACCBB?@B#
@4U9
TGCCGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTCCTTTTGTGCTTTTCTTTTTTCN
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJJJJJJJJJHHJJJJJJJJJJIJJJJJJJHGFF>BDFFECECECEDDDDDDDDDDDDBDDDDDDCDDDDDDC#
@4UA
CTTGGATGAAAATCTGCACAGTGTCCTGGTTCATCTACCAGCCTGGTCCATTCCAGCCTGTGTTCCATTGAGTTCCACAGGCACACCTGCCTGTCCTG
+
@@@FDFFFHGDFFHGDDHDIJJJHGHIIIHIJJCIJIIIJFGGCIGBFFGGEDF@@HBHFGEC8BBACHIF>@CEEECH=CEE@>BDC@A@>C>@@A@
@4UB
CCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCCTGTTGGAGAGAGCATGAGGC
+
CC@FFFFFHHHHHJJJJIGCHIHAHGIGJJGIGHIGGIJIJJIIIJJIJIJJJJGDGHIIJHIIIGGIGFHHHFFFFECBEEEDDDDDD?BDDDA>CB
@4UC
CTCCTCTTGGGTTGGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTN
+
@CCFFFFDHDHFFIJCGIHICHHIGIIBHGGIGGIIJIIJJJGIJIDFGIIIHGGIGEAGGEEHEDDEFEC?BBBDCDCCDDDDDDDCCCDDDDCCD<CB#
@4UD
CCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGACACCAAA
+
@@@BDADDHHHHHIJGJJJJJJIJEIIHIGIJJJGIJJJJIJIIJJIJJIHHFHHFFFCDDDDDDDBDDDDACBCDDDDDDDDCDDDBCDDDDDDDDDD
@4UE
CGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCN
+
@C@FFFFFHHHHHJJEIJGIHHIJJJJCFHGIHGIJIGDHIIJIJJJJIIJIHHHHFDFFFFEEEDEEDDDDDDDDDDEDDDDCCCDDDDDEDDDDDDDD#
@4UF
CTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGN
+
CCCFFFFBADFDBFGIGGIIIIIIIIIIIIIIIIGIIIIIIIIIIIIIIGIIIHEIIDHGFHIIIIIHHGFFFFFFCCDEEEC>ACCCCCCCCDCEC@@C#
@4UG
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTACATAGGAGGCCTGGGTGGTGGTN
+
@?8BDDDDFBD<>A:2CDEFGCGC>@+8;E9*1?D3D@<:B>@9*9B9<?)=F>BCAC)=@4C:=;=??CAE??7..(.(.;6.>3'(<AB?5(3<9?B5#
@4UH
CCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCT
+
CCCFFFFFFHHHHJIIJJJJJJHIJJJJJJJJJJJJJJJJIIJJIJHHHFFFFFFEEEEEDDDDDDDDDDDDDDDDDDDCCCDDDDDDDDCDDDDDDDD
@4UI
CGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJGIIJJJJIIIIFHIIIJJJJJJJJJJIJJJJJJJJJJIIJJJHHHHHHFFFDDDBDCDDDDDBDDDDDDDD?#
@4UJ
GTGACATAGCGCACCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGN
+
???DB?:B:??@)22A99<CFBE?E6DBEA19B060@AIICA@).==C>CCDDC=;ADAD>;6(;6,;3388)500>A>A::>:>:4<?>;50(28858>#
@4UK
GAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGN
+
B@@DDFFFHHHHHJJFHIIGIJJIJJIIJJJJJJJJJJJJIJJJJIJJEGGGIJFIJGHHEHFFFFCFECDDECDDDDDDD<CDEEDDDDDDDDCD:ACD#
@4UL
CAGAGAATACGTTAACTGATTTGTTAACTAGAGACAAAGCAAATGAATTTGCTGTCATGGTAGAGAAGGATACGCCCACTCCAGTTTGAGCTTCTAAGG
+
@@@DDDFFHHHHFJJIFGIIJJGJHHIEHIEHFHGIGEHJIEIJGIIIJIGGEGDEHGHGHGCICFHHEGIIIHIFEDFFFCEECDACDDCDDDDDDDD
@4UM
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTN
+
CCCFFFFFFHHGHJJJJJIHIJGIJJJJJJJJJJIJJJIFHIIGIIIJIJIHIIBGGGGHIJ5DHFAHHFDFF;=CCCCDDDDDDDDDBDDCDDDDDDCC#
@4UN
TGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGN
+
CCCFFFFFHHHHHJIJJJIHJIJJJJIJJGIIJJJJJJIIIIJIJJIBFHIIHDDDEEDDDDDDDDDDDDDDDDDDDDEEDDDDDDDCDCDDDDCDDDCC#
@4UO
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTN
+
?@@D+BADFDAF<CDD4A92ACEEEGGI?<<;DCEF)9BBFE<(=B@;FFADFI;CCEEEEFD>>BDC<>8=@BA>@BBB:@BB>BBBB?9?>3>ABDBD#
@4UP
GTCTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCN
+
???D:?;;=:C:D2@CEB::A++<?CB1?9<<ED@DI@D<@D>DECD?D@DDDDDEE485844/AACD=;;A@;@DA@A3>@>AAAAA3>>;5>3:AAAA#
@4UQ
CCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGAT
+
@@@BFFDDHDHHFEFFEGGHHIEHGEDCFBCEFHJCBCDFGIEGGGGHHGB@FFBFHAFH@DCCHIGFHHHGFBD;>@@B=?BA@CBDAC?>>@CBD?@
@4UR
CTCAGTTACACACTTCTCAACTTGGAAGCTCTCTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTN
+
B@@FDDDEHHHHHIHIIGJJJIJJJJJJJJJJIIJJIIIIGIJJJJJIJJHDGGIJJIJJIIJJJIHGIIJFIHEEFHHFFFFFFEEEDCEDDDDDDDBD#
@4US
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGAAAGAGAGAGAAGAGAAAAAAAAAAAAAAGCTTTTN
+
@@@DDDAD?CDA<BG?B@C<<AC@EEFFIIDEHECFIIGIF4?:?F:?:DBB<8?F@C@DD3@CCFEIDICEEA;BBBCBC>A@BBBB>BBBBB.844+(#
@4UT
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGN
+
@@@FDDDF8FBBDGGHHGCFHGGGEHIJIII>GII?FEHCHID4BDEGDHHIJHIGIHIIIC3@FD?GG9BAC;@DDFDBE??B@?@2?CD9@CCCACCB#
@4UU
CTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTG
+
B@CFFFFFHHHHHJJJJJJJJJJJJJJJJJIIJIJJJJJJIJJJJJIGJJJJJIIJJJJJJJJJJJIJIJJJJIGJJJIHHHHHHFFFFEEEFEEEDDD
@4UV
CGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCN
+
CCCFFFFFHFHHHJJJJJJJJJJJGIJJJJJJHIIJJJJJGIJJJIJJIIEIJJHIJJJIGHHGHFFFCD?ADDDDDDDDDDDDDDDDDDDBDCCCDCCD#
@4UW
CTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACT
+
C@@FFFFFHHHDHGIIIHGIIJFEHIHIIIGIGHEDIIGCFGGHIEFGGIJIIJIJJGIJIIHEHIIGIIJJJHHHGHFFFFDFEECEDEECDDCDDDD
@4UX
CTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATA
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJJJJJHHHHACEFFFFDEEEEEDDDDDFDDDDDDDDDDDCD
@4UY
AGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGAT
+
CC@FFFFFGHHHHIIIJIJJJIIJJJFHIIIJJJJJIIJJJJJIJJJJJJJJIHIJIIJJJGHIGIJIJIIIGHFDDDDDBCDDDDDDDDDDDDDDDDB
@4UZ
GGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGN
+
@C@FFFFFGHHHHJJJJJIJJJJIIJJJIJIIJJJJJJJJIJHIJJJJJJJJJIJHHHHHHHFFFFFFEEEEEEDEDDDADDDEEDDDD?CDDEEDEEDD#
@4V0
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
@@@FFF?DCBFDHIGHHGIJJJJGEHIEGGI:DFGGHIJIJI?DFHHGHEHGIGGHJGJJIHHG9??DDEEDEEDCCCDDDDDD<=CCDDDCDDDDDDDD#
@4V1
GCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTN
+
@@@DDAFFHFFHHGGGEHIBHIBDHIBEH7FCGHIIIEHHIJIGGEDDFHIHIGF>BEHHIIIIHGGGIGGEE?ADB<=CCC@AEBCACDDDA5:@AC>C#
@4V2
TTCCTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCN
+
;?1BDFDDFBHDFHGIGGIGGIIIEFHGGHEHHIGIGHIIGGB?DBFFFFEDHDGFGCFGIFIIIGIGIIGHG8?DACECACABB;>;@C<BBBCCA?CC#
@4V3
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCAT
+
CCCFFFFFHHHDHIIIJJJJJJJJJIIJIJIJJJIIJGGIIJJIJJJIIDDDDDDCDCDDDDDDEEEDCDBADDDBDDDDDBDDDEDDDDDDCCDACD
@4V4
CCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTN
+
@???DA?DHHAF<EABGGG<:@DGHICCDGHCH<@:DGBBFHIGAC@.=A@4=ABDEE>>@CC;A=3;>;:@<A>?C@>@C?897+<C@3>:@@?@))5&#
@4V5
CAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGN
+
?<?D?DDDDA?HBB?EBCAC?CFFFHCBGGCBDG?F<<;FG98*?=CB9BC>C@8CDAHEE>??@;B>7=6;?(;CC((:@>ABC>:>3+448@B@@88:#
@4V6
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGAAGAGGAATAGCTGGTAGG
+
CCCFFFFFHGHHHJJJIJIIJJIGGIJJJJJJJJGHIIJJJJJJIJJJGGHJGIJJJIJJIIJJJJJJJJEGHHFFCBC(>CCDDBDDDDDDDDCCDD
@4V7
CGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCC
+
CC@FFFFFHHHGHIJJJGHGJJIDIIJHGGGIJJJIJHIJGJIG@GIIJJHHHEFFD=>BDDCBDDDDEEEDC:ABDBDBD?ADDDDCDCDDDDDDEDD
@4V8
GTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTA
+
@=@DDDDFHFHHFEFEGEIIIIJEGBEHCBDFGAFFDFC@GDHGGDGGHIIIJEIHIJGIH8;6;=DHCEEE=?H?EDDDE>;@CD@CDDDB?@BDDC
@4V9
CTGCCGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGN
+
@CCFDDDFFFFHHJGCDHICHHGEGJGHGHHGHIIJJJJIIGEGBGIGGEGGIGHHEGICH;FHCHGGHICGIHGHHGFCDEEFFE@;;A>>CC@?@?B@#
@4VA
CAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTC
+
CCCFFFFFHHHDDGIIJJIJIJJJJIJJJJIJJJJJJJJJJJIGIJGIJJJJJJJJJHFHGHFHFFFFDCDEEDFDDDDDDDDDDDDDDDDDDBDDDDD
@4VB
AGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCN
+
CCCFFFFFHHHHHJJJJJIJJJJJJHHIJJJJHIIJJJJJJJJJJJJHIFGIHIJJJJHIIJJJJJJIIJIHHHHFFFFFDDDDDDBDDDDCDDDDDDDD#
@4VC
GGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCC
+
1:=DDDD;2CDD?EB?E>DFFDIIIIAFFCECE<B9CE>C9::DDEC3?BCE@BDADBEBDEEEDD>C@AECEE=;@ACCECD:7AAA@AA>DAA6>AA
@4VD
TGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGTN
+
@<@DB??;FFFFFI<E:A9++<?B9?)CD<DC@D)B;6DFFEEEFDF<CF==D=E=@CFCCEDD89@BB@@@@BB:50<<<<B@B>@8?8<<>BBB@A?+#
@4VE
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
CB@FFFFFHHHH?EFHJJIJJJJJJJJJJJJJJIIIJJIJJJGHJJIGJGIJJJJJJJJJJJIJJJIGIGHHFFFFDDDBDDCCCCDACDDDEDDDD
@4VF
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
@@@DD?D?BFH<D>EGG@HCHGGH>?CG;CCFFCFC@FEHHIGIGGIAGAHHIAHAEAGEFHEHE?DCA:C@>ACD;5@5;@ACC@ACC93;:>:>B@<>#
@4VG
GGTCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
CCBFFFFFHHHHGIJJJIJJJJJJJJJJIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIIHHHHFFFFEEEEEEDDD9=B;CDDDDDDDBBDDDDDDDDC#
@4VH
GTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGN
+
CCCFFFFFHHHHHIJJJIJJJIJJJIJJIJJIJJGIJJJJIJIJJJ=FHIJJJJIIJJJHHHHHFFFFDEEEEEDDCDDDEEDDDDDDDDDDDDDDDDDE#
@4VI
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJIGHIHJJJIIJJJJJJJJJJJJJJJJJJJHHHFFFEEEEEEDDDDDDDDDDDDEEEEDDDDDDDDDDDDDDDD#
@4VJ
CCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAA
+
@C@DFF?DHB?FFIIIBEBHEHIIIAEAGGGEGGGDGGIIEGCEIGGIIIDAFHCEBCFFBFDC@GGEC@@=7CEHHHFHGFDCBB<CC>CCCCC5>>>
@4VK
CCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGTGAGGAGGCTCTCGCACAGCTCCGCCCGCTCCAGCGACTCTACGCTGAACATCTN
+
CCCFFFFDHHHHHJJJJEHHJJJJJJJJJJJJJJJJJJJIIJJIJJIJIJJJJJJJJJJIJIHHHHFFFFDDDBDBDDDDDDDDDDDDDDDDDDDDDDDD#
@4VL
TGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCN
+
CC@FDFFFHGAHFBGHIBEFH<CHGIFGIGEHHIGGICGGHGFIH=F=CAHHII@DDCEHGHDBEE;@CDDCD@>ACCCCCCCCDDDD<CCCDDCD4>CD#
@4VM
GACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGN
+
CCCFFFFFHHHHHJHJJJGIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJFHIJJHHHHBEFFFFEDDEDDCEEDDDDDDEDEDDDDDD8ADDEDCDEEED#
@4VN
CGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGG
+
@@?ADDDEDFA>FBFHHFHGHFGGHIG:CFGC>B?DC@GG@FHBBGEBFGCGHIGE??EE;=CDFFFCC@CAC?;?CCAAC>CCCDD09@5ACDA:@@@
@4VO
GCTGTATTAGCTGCTCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTG
+
CCCFFFFFHHHHFIIIIJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJIJJJJGIJJJIJIJJJJHHHGHHHFFFFFFFEEEEEEDDDDDDDDDDDDD
@4VP
CCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAA
+
CCCFFFFFHHHGHJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJHIJJIJJJJJJJHIJHHHFHHFFDDDDDDDDDDDDDDDD
@4VQ
GGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGN
+
CCCFFFFDHHHHHGIJJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJHHHHFFFFFFEEEEEEEDEEDDCDDDDEEDDDDCDFEDDDDDDDDDDDDD@A#
@4VR
CTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCA
+
@@@B?B4B<<DAFHGGDGHII9EEG:F?E7@*1?EFGGCFCDB<DDG@HDHGG@DBE:BF>FGBCCDGGCGGGEHE@AH>>;@B=@A;A;@
@4VS
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFADDFHFHHFIGHBGHHJIIIJIJIGIIGIG?DGEDGIHEHGG==CAGEEDAEAACACFFDEDDDC@@DDDDDDCDCDCA@>A@C:A>CBAC:@C:@#
@4VT
TGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIIJJJJJJIJJEIJJJJJIJJJJHFHHHHFFFFFFEDDDDDDDDEEDDDDDD#
@4VU
TAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGG
+
?@@D==?B=CFDFGHGGIGIGIGHHGCA<CDGI:@80??D?BDCFGGHGGGIGHA;EG@CEHH<9BCC@CCD;AC;5@@CCA>:>ACCCACDC:+44@C
@4VV
TCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCN
+
CCCFFFFFHHHHHJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJIJJJJIJJIJJFIJHHHHFFFFFFEDD9@D?DDDDDDDDDDDDDDDDDDDDDDDDD#
@4VW
GGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
@C@FFAFDHDHHHGGH:CBFHGHII?FGIEGHHIIIIIJFGHGFHH<FHIIICCGDHGB4:@;;6?CACC;@CDAA>;C5>CACCCCCBDD3:ADDCCC
@4VX
GCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGN
+
@@@DDADDDCD?A?E<EGHDEFFHHIFEFBH?CBG?CGHDBHAD???F?::FB@G@DFB???F<8=BFHFDGFGGG@==A=AEEEEEBCCEECCCCC?CC#
@4VY
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
;?@FDFFDDFHHFGIGBEGGGGCC@GGIIIIIIIEEHIIHIBDFHI;FGGHEICAEECCEBBBBCEEECCCA@CCCCCCCCCCB@CCCC@CCCCCCCCCC#
@4VZ
CTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTN
+
CCCFFFDFHHHHHJJJJJJJJJJJHIGGJHIJJJJJIIJFHIJJJJJJJJJJGIIJJJJJJJIHIIJIIIJJJJJJJJGIJIJIHHHHHHFFFFFFEEEE#
@4W0
GTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCACCCATGGTATTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGN
+
?@@ADDDBD?<?A:CC+2@?D8CF??BGCG<;G<?0BFA;'4=>E;7)6?BAA@.65(-;>BB@;5,5@BBB99,9<0598:::ABA>BBAB:4>>?BBB#
@4W1
ATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATG
+
CCCFFFFFHHGHHJJJIJJIJJJJJIJHIJJJJJHIJIJJJJJJIHGJJIHJJIHIJJIIJIJIIJHIJJIJHHHHGHHFFFFEDDEEDDDDDDDDCCD
@4W2
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@?@FDDFFHGHHHJJIJIGHIIAGGGIJJGIJIEHIIJIIGHFIIGGIGJJGIHGGF==@DDDFCECECDCCDDDDCDCCDCDCCCDDDCCB@BBBBDC
@4W3
TGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCCAGTTCCACAGAGA
+
@B?DDFFFHHHHHJIJJJJJJJJJJIIJIJJJIJJJJJJJJJJJJJJJJJJJJJJIHIJJJJIJJHHIJIJIJJJJGHHGGHHFFFFFFEEDEEEDDD
@4W4
GGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAAGTCCAGCATAGCCAGGG
+
=7?D=AB?33CAFDE1<:<C3?+AA+AFGDGF<?1CB9:D?FB?<?DG@DFDD=(.(=@=@@CD@E6444?@36;?BB@B((,5(5>?<A((+4>2<<
@4W5
GCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGN
+
CCCFFFFFHHHHHJJIEGGGIIFGGIJJJJJJJJJJHHHHFFDDDDDEECDDDDDDDDDDDEDDDDDCCCDDDDDDDDDBDDDCDCDDDDDDDDDDDCDD#
@4W6
GCGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTA
+
@@<DDDFDDDHGHJIEGEEGHFEGIIJJIGGJJIJH@GDHIHHDHJIDHFHFFFEEEEEEDCDCCDDCBBCCCBBBDDDDCDDD?CCDCCDC::ACDDD
@4W7
GTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGN
+
BB@DFFFFHHGHHIJJJJJJJJJJJHIJJJJHHJIJJJJJIJJIJJFHIJJJJJJIJJJHHHHHFFFFEEEEEEDDDDDDEEDDDDDDDDDDDDDDDDDE#
@4W8
CTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGC
+
@@@DFADBHDFHFHGGGHHHIIFCGHCCCAHHHGAHICE@BBGGGHGGHGIGIIIGIIIGGGGIIIGGCGCHGGH?AA?A>CBBCEECCEDC>CCACDB
@4W9
CTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATC
+
@@<DDFEEHHHHGJJIIJJJJJGCEFGGHHHGIIIHBEFFIHHEIIIJJIF?FGIIHJGCHIIIJHDD8>BDDCC?BCDDDDD>@A<??CCDDDDDDCD
@4WA
AGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTN
+
@@@FFFFFFHHHFEGEFGFGGIGHHGIGGEEGGGHIAHG?DHIIIJGGGGCCHEHGEDF>BDDBEDDDDDDB=?@CCDDDDDDDDDCDEDDDACCDEEDD#
@4WB
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
=@@;:?:DFHFF1<CEHGGHHBH??@F@0-&68@@>+8+8838BAB@CC<(99?<?5@BB8>33:A>A:4++:::>>:AC:05)00<:@BC>C:A+:??
@4WC
CTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATN
+
;@@FFFDDHHHDHGHGGBECHEHICDHHHIDHIIGBGEHIDEGFDEIIIICDBGGIIEHI8EEEE=FDGGGIDHIDHEHHBHH@D@@B>>C@>3;@>CCD#
@4WD
CTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTC
+
@@@?DA2BFAFHDGGGHICAFC:?EG?BCFFDGHGGIEGBAAFEGGHIAEGH@EECHHEE@BBBD;@A@CCC=;ACBCCCCCCCCBB@<<8?<?B4>>@
@4WE
ATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGC
+
C@CFFFFFHHHHHJHIIJJJJJJJJJJJIJIJJJJJJIJIIIJJJJJJJJJJDDDDDDDDDDACDDDEEEDDDDDDDDDDDDDDDDDDEDDDCDDCDDD
@4WF
GCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGN
+
@??DDEFFFFBFHIFEDAEHDCCFDHBHEHGGGIII@GGGGIIIHIIGDBDGFDCHIHDFHGGGGGIGICHIIICHHGIEAE>E>;CBFDFCACACCCC@#
@4WG
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCN
+
8?@D;DDDHFHFFGGICHGGHHCCFAFBHGE@HIIBHGH>@F89CFBFHICHHIG@>=EECCECDDDBC@AC,3=;AACCCCBB>BBCC@CCCCCCCCCB#
@4WH
CTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATN
+
@CCFFFFFHHHHHJIHIHFHGIJJIJJJJCFGIIIIIJJGIGIIJJJJJGGBHGIIIJIIJIIIIGHGHHHGFFFBE>CCCBBBD=ABCCDCCDDCDDDD#
@4WI
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
@C@FDFDFGGFFHIGJJIIJFDGHICDHIIJGGGIGIJGGIGIJJGGGGECHIHHEHHDFDDDDCDDCCCCCCBDCC>C>BDDDDDCDAB?BDDCCDDCC#
@4WJ
TGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGG
+
@BBFBDFDHHHHGJJDGIJJIJJIGIJCHI@FHFHIJIIJJII8BGAGIIIIFFHFHFEFFCDDBBBDDDDCDDDBADDBBCDDDDDDCD@DBDDDDB
@4WK
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHDHFIJJJIIAFEHIHIJJJJIIGIIIGHGGIIGGIJIGHGIGGHGJ=AG@EH=EEHFFFEFFED>CCA@D8@CDEDDDCAACDDBCCDC
@4WL
CCCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCN
+
CC@FFFFFDFHHHJIIJHHGHIJGJIIJIJJJJJBFHHJJJJJGGGIJIJJJJGGIJJJIIJGIJIJIDEHHHHHFFFFFFDEEEEEEDDDDDDCDDCCD#
@4WM
TGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAA
+
@@@DFFFFGHHHHJJIJJJIIIAHIIHHJJIIJIIJIIJIGEHHJIIJJJJJJHHHHHHFFFDDDDDDDDDDDDCDDEDDDDDDBDBDDDDDDDDDD
@4WN
GTCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGN
+
CCCFFFFFHHHHHJHIJJHHHIJHIIJJJJJJJJJJJIJJJJJJJJJJJJJJGHIIHIJJHHFFEBDEFEEEEEDEDCDDDDDDDDDDDDDDDDDDDDDD#
@4WO
GTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGN
+
?;?=B=B?8B>FB?FFGGGHGGEG?F@CBB0?DDGH@F9?D8)/8CCCH>;@@DADE==CEHEEBB=>(9;?@529;8;'2:>BCCB4:228<@<<><@@#
@4WP
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@@@DDDDDHHGHHIIJGGIGJJJHI@GHIIJIJGJGIJJIIGHIJIJGGHIJJJJEHHHIFE@@E=CEHHFFFBEDFFFDDD,;?B=@CDDCDCCBBADB#
@4WQ
GTTTGCTTCATCTCTGGACTTATAAATGCTATTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTN
+
@C@DBFDFGGHGGIIJJGIIIIGDIIIGIBFHIJGIIIIJIJIGIIIJJIIIJIGIHJGEIIG3;CDHIGGIICGGIECCA>??CF>@DEECCC=ADBBA#
@4WR
TGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTN
+
?@=BD?D:?F>FFEFFB:<C?@AAC@EGC?<EBDF?1*19?BF@GDHIII@DF;;CB;C;;/4===>@BACCD@@CB?>(5>:>A>@CCC>A>A(++9+4#
@4WS
TCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGC
+
@@7?BDBA2A<:AFF<:AI?:3AFECDFBGI9<:<9CEG?:?><99B?9988?DDDB=C)8@=1.;81('3,8;:;@AB95:5>(4(3?BB@>A>3593
@4WT
TGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCTN
+
1+:?D:A?D>C?:822AEAEFAC99A>9EEDIII=DD:AD</==>7=A=;:5=6577?;;36>A/99=29>>>5>:=&5&)0)9080<>?>;9&&5<<8<#
@4WU
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGN
+
@@@FFFDFHHHHFG@EHGDHDHHJGGHEFGGIHEBHEHEBDBDD@DDCDDDCDDDDDDCCDCC@A4>@@@ACCCDDBBDCA>>:@CACCC9><<C?AC@C#
@4WV
GGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTN
+
CC@FFFDDHGDFHICHJFHFIIJJJJJGDIIJJIGIJJJGHHHEIIGGHH=FGHGIJIHFHGFFFFDDFEECEEEEDDCDDDDDDEEDDDDDDCBDCBBD#
@4WW
GCCTGCTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCN
+
CCCFFFFFHHHHHJJIJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJGHHHHHFFFFFFDDDEEEED#
@4WX
GTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTN
+
;@@?DB:BCH??DDEFBGGIFGGG??9@GGFHEGGHBB?DGFDGHCEBB8BFFCCHFHCEHHB<E>@B@CECC=>;;>??990<@?C>A@C::ACBBBB5#
@4WY
CGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAACTGN
+
??<DBDD<C>FDD@?FD<:F9B@:0)C81?6086BF8(*/=F<=/8=C7;=6@EA93;88<9@B>ABBB35;5@9&0<B?2:<B::44:>:42@A3(++4#
@4WZ
CTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCN
+
CC@FFDDADFFFFHGHIGGHGGCFHHIIIJJGIHHIHJHHHIIIIIGHIJJJGFDFDB8@BDDDDDDDDBBCCACCCCDCCDDDBD-<BBD5>BDDBD<B#
@4X0
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJJJIIIJJJJJIJJJJJJJH=BCCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@4X1
CTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTN
+
CCCFFFFFHHHGHJJJJJJJJJJGJJJJJJJJJJJJJJIJIJJJIJJJJJJJIHHFFFFEEEECEEDCCCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@4X2
TCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTAACCTGCCGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCN
+
?:?D;DDBFBAADHGFB@A<EH<FFGF>HHIGHIGH>DFGEB@GE:DAE>>FC4BBBBCHGC@4=F=CEH@CGEEEHCEBDDCE<@CC>>>CC>A:;A@?#
@4X3
GCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTTTTGN
+
@@+ADDFFHGHFHJJIIJJJJJJIJJJJIIIGIJJJJIJJJJJIJGHFDFDDEEEDDDEEEEEDDCC@CDDDDD?ACCDDDADDDCDDDDDDDDDDDDDD#
@4X4
CCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJIIJJJHHFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD@BDBD#
@4X5
GCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTN
+
@@<FFFFFGHHHHIHGJJJHIJJIJIHGIJIJEIGIGHJJJJJJGIGHGEGIJEIJIIJJGIIII8CGHHIHIIIJJGHHHGGFFFFFFEE>CCCEDDCD#
@4X6
GCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCN
+
???BBDADDD?+22A<:::C>@ADF?EEEEI7?8C3DDDDA;D;8?DD>=<=BBCDCACE>;@CE;5==?@;;;;@A@3;;;;>:>>>A>=159<>:>3+#
@4X7
GTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTN
+
1+:A7DDDD?D<DEE@EAD:?0888;ADDC88A=549=;=A;588;<?5557<8==6?>>>A:A:::>>>(>9838>?<>AA:>>>>9>?+388:>A>>>#
@4X8
CCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCN
+
CCCFFFFFHHHGHJGIJJHIIJIJJJIJJJJJJIIGIJJJIJJJJJJIJJIJJJIJJJIJJJIIFGHFFFEEDEDEDDDDDDDDCDEEDDCDCCDEEEDC#
@4X9
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
BCCFFDFDHHHHHJ@GGIJJJJGHIIIIIJJIIEHIIIGIJIIJIHIHIJIJJGIIIJIIJJJJIIGHIJIIJIFHFHGHFF??BBCCDCDDDDDDCDED#
@4XA
GTCCCGTACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTC
+
@CCBDDDABFHDB@B@HIGIIBEGGGHIHIA?EDHBFFGDG@D@DGIEGH@FHBHFEGDC=BF@D>FFIHG=CCHECEHE;BDECEEEE>;A?CC?B;?
@4XB
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
@C@FFFFFGHHHHJ<CFHHJJFHIJGHIIGGFGGFHHGIGIGIEHIIIHHHFEFFEFECBCCEECDDDDDDBDDDCCCCCCDACCCDDDC@CCDCDDEDC#
@4XC
GGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTC
+
@<?DDDDDHHDFHCFHIGGGICHGIIEGGIFHAHDAGICGGE>DGG-=FCHIIGEGHA)7?:CDFFBFE@CEEA=ABBBC@?<?<?ABCA?CCC@CCCC
@4XD
GGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCN
+
@;?DDADDHF?CFHIIIIIIIIIIGIIIIIIIIHGIGIIIIIHIIIEHIEEDGHIGGGIIIEGGGHHGI@@FEHGGGIIDHFEHEDEECEDECCCCCCCC#
@4XE
GCCCGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTAAATAAAAAGCN
+
CCCFFFFFGHHHHJJJIJJFGIJJJJJJJJJJJIJJJJJHJJJJJJJJJJIJJJGGGJIHIJIJJJJJIJJHHHHHHFFFFFFEEEEEDDDDDEDDDDDD#
@4XF
GTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCN
+
@??DDDFDDFDFBEFGHGHGEF>GIEGG@HEHGGIEHEDDDHHHIDEEIGIGGHIEGIGIJHIFHEHID@@GHGDAEDHGEEEEHGGFFB@?C>BECAEC#
@4XG
GTGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTN
+
@@@DDDFFHFHHHIIIIJJIIGCFGHIJIGGEIJGHIJIGIJJGHIEE>CDFFFCDECDEEEDDCDDDDEDDDDDDDDDDECDDDDD>CCDDDCCDCDCC#
@4XH
CTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATCATCGAGACTGCCGGCGAAACCGTCCATCTTGCGGGGAAAGCGCN
+
8@@D?=BDF4DAF?GFIE1CEA>EG@>EF3?F:4C:0??FFDGIDFGC;BBF>D<FEFGIE@;=@ED;ABB<B8?BB@58952:4>:4:>505@98?395#
@4XI
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACCTGAGGAAAGAGTC
+
@@@DFFFFHHHHHIGJJGHIIIGIJGHGGGHIIHHIDGIJGIIIIGIGIGGIIGGHIIHGGHHFFF9>B?CCCCCDBDDDDDDCDDDDDDCCDDDDCAC
@4XJ
CGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCN
+
BCCDDFFFHHHHHJJHIJJJIHHIFHICFHJJJJIJJIJJJIGIJJIJJJJJJIJJJJIJIJJJHHHHEFFFFFEEDDDDDDDDDDDDDD>CCCDEEEDD#
@4XK
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
@@CFFFFFFHHHHHIJJJJJJJJJJJJJJJJJJIJJJIJJJJIIJIJIIIJIJJJGHGJJJJJJJIIHHHHHFFFFFECEEEDDDDDDDDD?@D<BD9B
@4XL
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
??+4ADADDFDDBEFFFFACFHEHFHED9F?F:CD@B?F9900?DF8BDFBCFF@DDFFFIIFEECDD?>B.69@>;@@A55==@@@5,:@@ABBA>@
@4XM
GTTGGAATGAACTGCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
?@+=ABDDFHGHHJJIJIIIIGIIJJGIJJJJJGIIGJHIJJJJJGIIIIIHIFIIGIIIJJJIDGIIGHHHHGHEBDFFDDC,9@D8>ACDDDACDD
@4XN
CCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATN
+
CCCFFFFFHHHHHGJJJJJJIAFHIJIIIJIIIJJIJJJJJJJIJJIHIJIIJJGHIJHHHEHHHFFFFDDDEDD@CDCCCDCDDDDDCDDDCDDDCDDC#
@4XO
GTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAACTTCAAAAAGAAATTGAAATACTCAGACAAGAAGAAAAAAAAAAAAAAAAAGTTTTCGN
+
@=?DD?BAFFBFA4C:AF:;FFHEECBEH<HEEHCDGGG<@DFGFFIIFFIFCFFGIGFEGIEGGEBFIE@=D@=CEEFFFDCBBBBBBB>5&&((+4(5#
@4XP
CTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGN
+
=?@DDD??C=CAA<::<E<CA@8<<82?FF?FD08?;;B??6?8;;FD@EE-=9;;7;>6;',5,55;CA5;:(::@>C?><>9:C@C>>:A@>>4:A?9#
@4XQ
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@CCFDFFFHHHHHJJJJJJJJJJJJJJJJJGJJJJIIIJJJJJJJJIIJJJJJJJIJIJJJJJHHHFDEEEEEDCDDDDDDDDDDDCDDDDDDDDDDDDD#
@4XR
GGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCN
+
CC@FFFFFHHHHHJJJCGHFIIJIJJJIJIJJJJJIJJIJIJJIIIIJJJJIHJJ@FIGGCHHHCEHFFFCED3=B9@CCDDDDDDCDBDDCCCDDDDDD#
@4XS
AGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
@@@FDDFFFHHDHIII8CEHHGIIIBHAGIIGGIIGGEIHIIIIIIGA@ECAHAHHHHFFFFDDEECEEEDDCCCCCDDDECCDDDDDDDD@@DDDDDD
@4XT
CTTTTTGTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGCAA
+
CC@FFFFFHFHHHJJJJIJJIJIGIJJIJJJJJJJJJJIJJIJJJIJJJJHIJJIIJJJJGJIJHIGIJJFIJIGIJHGHHHHFFFDDBDDDDDDBDDB
@4XU
CTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCN
+
CCCFFFFDHHHHHJJJJJJJJJJJJGJJJIJJJBHIJJIJJIIIJJIJJJJJJJJJJHEHHFFFFDDDDDDDDDDCDDDEDDDCDDDDDDDEDEDDDDDD#
@4XV
CTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATN
+
?@<BDDDDBDBDFEBADBD?EDA:B:FCHG>AC<??;)CFGGGFGAFDFHF@GAGHIGGA.;C<6@5?EC:=CHEEEDEEE;;CA(;-;@5?;>>:>,;5#
@4XW
CTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTN
+
@@;DDDFFFFFHFIIIIECFGHIIJIJIJIGIGGJIIIGFFHFGGHEHDFHIJJGJJIJBGIJHGGHFFFFEEDDC@BDD<CBA@DDDCCDDDBBB<<BC#
@4XX
TGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJIIJJJJJJJJIJJJJJJJJJJJJJJHHHHFFFFFFFEEEEDDDD
@4XY
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
@C@FFFADFHHFHIJIIEHJJJJJIJGJGGDGIJIIJJIIGHHEHIIJJJJIIJHHGGHIGGGIGGHHGHFEFFFFEEEEEEEDDDD;@BB>CCCDCC@@#
@4XZ
GTGGAGCATTTGGGAGAGCCCCAGCTCACCCTTGGCCTGGCGTGGCTGTCCATCCACAAGGATCATTGCATCTGGCCCATGGGCCCTGAGGAACTTATTCN
+
??<=4A8AD:4:C@D1?EE;?@DF@EBBEABD9??@0:DD>A(;@8=CACIADI@?C7;;?(;?6;;;AAD(;;;A;?8A?A?<5&+2398:28A:4:AA#
@4Y0
CTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAA
+
@@<DDB?DHHDHHIIFHICHGDEBGHIGIIIIIGIGGEGIIICGIEGGGHGBFHIIICGHIIFGIBEGGHEFGIIIIHHHEFHACB@DCD@EEEECCCC
@4Y1
CTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGN
+
CC@FFFFFHHHHHJHHIJJJJJJJJHHJJJJJJJJJJJJJJGIJJJJJJJJJJJJJIIJJJIJJJJJJHHHHFFEFDDEEDDDDDDDDDDDDDDDEDDDD#
@4Y2
GGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTN
+
@@CFFFFFHHFDACFHIEIJIJGIGHIGCHIJCGIIJJGIJGGIIJIJIIFHGDHHIGIHHGGEFFFFEDEDDDDDBDDDDDCDDDDDCAC:@A@BCBCC#
@4Y3
CAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTN
+
CCCFFFFFHHHHHJJJJJJJIJJDDDDDDDDDDCDDEEEEEDDDDCDDDBBDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDD@CCC#
@4Y4
CCTCGCTGCAGTTGGCTGGCCTCTCCATCCGGAGACCGGGCTTCAGAAGGTTGATGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGGN
+
1114+)200<+2A+2<E1?BC+++:?91:8C0)0)0870'-;CA).7==C)7)7))(;>A;>88'(((,,+<(44:A:(2:>?91&&)+++:305?C?B&#
@4Y5
GCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCN
+
?B1ADDFFHHHHHJJJJJJJIIJHHHFJHJIJIJIIJJJIHIJJGIJIJJJIJJJJIGIIIJJJJJJJIIJJJJJJIJJJJJGIHHHHHHHFFFFEEEEE#
@4Y6
CTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCN
+
@CCFFFFDFHGHGJJEIJIIIJGIEHJIJJJJJIGIFHIIDIJJIJIGIIJGEGGIIJJGIIJCHHJHHGHF?BD9?B9?CCAACCCCDC:CDA?B5ACC#
@4Y7
AGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCN
+
@@<DFFDDHHDBFGGHHHIEHGGIGHJFHIIJIGGGGEFGIDIBGHCHDHIIJIG7ABH=EEHFDFDFFFD=BBBBDDCCDDCCDCCDCDDDDBDCBACC#
@4Y8
GGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCN
+
@<@?DDDD?BFFHBDAFBB@B8ACCCC33@8BBADAC8?>8>ABBBBBA<CCCDCCCCAAC:CACACCCCBB@;<9>>?C39:ACCC<@A(:94>C9:>:#
@4Y9
CTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGC
+
CCCFFFFFHGHHHJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJIJJJJJJIJJJJJHIHHHHFFFFFECEEEDCCCD@CDDEDED
@4YA
CATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCN
+
=?+=DDFFGFFHBHHIIIIIGIIIEGIIGGCFHGIGIIIIIGGGIDGEHHGGH@@DHCEDHAADFFFFEADDBBCDDDEDCABCCCCC@CCACDD:ACCC#
@4YB
GCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCN
+
@CCFDFFFHHHHHJJJJJJIJJJJJJIJJJJJJJJJJJIJJJJJJJJJJJJHIJJJJJJJJJJJIJJJJJJJIIIJJGIJJHHHGFFFFFFEEEEEEEDD#
@4YC
CCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAA
+
@B=DBDDFHHHGHJIIIJJJGIIJIJJIGJJIJJJGGHJIJJIBIJJJJIIHHHFFDEDBDDDDDDDDDECB@BDDDDDDDDDDDDEDDDDDCDDDDCD
@4YD
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
?@7ADDFAD@FHFGH<DAEEHEGE@FHHGIC?G?DF@FHHIDGBDFGHIFHGDFGBD>FCFG@DAHIIGGDIHEB>@?DE@@C@CEEEC;5;CC@=@C?B#
@4YE
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
???BDDBBD4C<?E4:ECEDCFA<<:1:EEEICDFA*:B??DEIIIID4*?/?BB888=A)57;(.7===7=>?@D@;?=<?,8388>>>A>>448>889#
@4YF
GCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCN
+
@<?D=A>DA?FBFHEB>EGGEEHGDHAE;9C?F@?ADHGIIG>(==7?@D@@BB@AB:='89>?CC:>>:@CAACCC>C4:>C:4>4@44AAADDCC>@C#
@4YG
CAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTN
+
@@CDDDDDHHHGHIJJIIED?HGHGGHIGHHGIEH@=F?GEHEGDHHJBFHIJEHGGHIGH=CFEGGGGIHIIGIHHGCBC>ACECDDDEDDDCDCDCC:#
@4YH
CCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCN
+
CCCFFFFFGHHHGJJIJIIIHIJJIJJIJJDGHGHIJJJJJJIIIIIIJJJJJJJJHHHHEDACEACDCD>CCCDDDDDDDDEDEEDDDDCCCCCDCDDC#
@4YI
CTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCN
+
@CCFFFFFHDFHHIGIJIJJGGIIIJCHHIIJJJHGIIJIIHIIJJIJJFHGHHFBCDDDDDDDEECEDDDDDDBD@BDDDA@BBDCDDDDCE>CCCCCD#
@4YJ
CATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACN
+
@C@FFFFFGHHHHIIJJJIJJJJJJIJIJJIJIJIIIIEGIJIGJJJIJJJJIIJECEIIGIJIGIIIGEEFDFFFFEEEEEDDCD@DDDDDDDDDDEDD#
@4YK
CTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTA
+
CCCFFFFFHHHGHJIJJIIJJJJJIIIJJJHIIJJJJJJJJJJJJJIIIIIJJJJJJJJJJJIGHHHHABBCEEDDDDDDDDCDDDDDDDDDDECDDCD
@4YL
GCCGTTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTN
+
?<;BD@BDDFB<ACC?A?EDBGE@AHH?C9CCGDB?@@:@F:?BBBFHCA/??B?9?FCC<=FEDAAHIIA>=77=@BE>=?>C@;5A;(:>>C>>@@@C#
@4YM
GAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCC
+
B@?BDEFFHHHHHIJJJJJJJJJJJEHJJJJJHIFIIIIJHJJJIJIJJEHIJFHIJ;@EGIJJHHHH?BEFECEDEEDDDDDDDDDDDD?BDD@CDD
@4YN
CCCGTAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFDHGHHHJIIJJIGIGJHGCFHGIIJJIIJJFIJGJJJJGGGIIIIGGHHFFBDAEECCAACDDDCDDDDDCACDCDDCC>:A?BCCDDDBA
@4YO
GAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCN
+
C@CDFFFFHGFDHIIJJJJJJIJJJJJJJJJJIJJJIJJJJFIJJIJJJIJJIGGIIFHIJJGIJGHGHHFHGF=ADDBCCDEDCDDBDB@BDDDDDDDD#
@4YP
GCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCC
+
@@@DB;BD>BDDD;BDFFIA@CFH?HCFDDCBD?CCGGFC<:CGB???4?BGDGDAGHGEGCDDDHGCB=8;@CGGHIF7==A=;?CE>>;C>;@>D;5
@4YQ
CCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGA
+
=@<DADEDBDDHHIFHGFGGDEGDF>GHEHHEBEB?FCEEBFCE:DFGIEFG=FFHEIGCCBBBCCCCBBCC?@A?>CCCB?>@ACCCCC@C>CCC?8>
@4YR
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
??=DDFFFHHHFFIGGGIJIIJIJIABFGIHIGJIEIIGHEIJIJIIJFGHHIJIDHGHGGIGGIGHHHHGEDCEFFFFCCB;=BD=@CCDCA@CABBDB#
@4YS
CCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGN
+
CCCFFFDDHBFHBFGDHIEIIFGGIIIJIG?EFGGIGFIFGGHGHGH0?FDBFHIBHIFEIEGIGGGGIGIGII@HEDHHFHHBA@DFCD@DECEA>CCC#
@4YT
TTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTN
+
CCCFFDFFHHHHHIJJJJIHIJJJJHJJJJJJJIJIJJJJJJJIJIJJJJIJJJIIHIJIHIIJIIJIJJJHEHHFFFFCAEDEDDDCDDDDDDDDDDDA#
@4YU
TGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCN
+
CCCFFFFFHHHHHJJJJJJJJAFHHIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJHHJJIHHFFFFEEEEEEDDDDDDDDDDCDEEEED#
@4YV
CTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATAC
+
CC@FFFFFHHGHHJJJJJIIJJJJJJJJJJJJIJJJJJJJJJJJJJJJHIIIIJHIIIHIGGGGHIJJJJJHHH?EHFFFFFFFEEEEEEDDDEDDEED
@4YW
TTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTG
+
=@=DDDFFHFHHHJIIJJIGHIJI>DHHIGHIJGGEGGFGFHCGCHHHHIDGGIFGICGIIJEGIEHJGHGIGCCC=CFGHA;DGGIFHHHCE>?@DEC
@4YX
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGGGCAGTGACTGGCTGCATGGGGN
+
CCCFFFFFHHHHHFHIGGFIHHIGIIJGHIIIJIJJJDGIIJ?BGIGEGHHIJIGIHIIHIIJ@CGF(7?DFFFFCED'9=BBCCDDDCBDDDBCCCDDD#
@4YY
GTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCN
+
BBCFFFFDHHHHHJJJJJIJJJJJIJJJJJHIIJGIIJJJHIJHIJJIIJJJJIIJJIJJHHHFFDD=CDDEEDDCDD?BDDDDDDDDDDDDDDDBDDDD#
@4YZ
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGN
+
C@CFFFFFFAADAGHIJJIIIJIHBHBHIJJJJJJJJIGGIIIJJIJIHIIJJIIJIIHHHFHFFFFDDDB@CDDDDDDDCDDDDEDDDDDDDDDDDCDD#
@4Z0
CGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@C@FFFFFHHHHHIGJJFHIICGHDHD?EHIJHIJJJJGIJGIIJJJEIHIGHJIIIJJIJJGHGHEEHFBDEFEEEDEECCCCBD=BDDDCCCC>@C
@4Z1
CTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCN
+
<@@?DDD;F?D:C2ACGFFACFIIIID@EH3AEGCFGIFFGFFG@@>BDGFEECEE@@FGGFGGFEFGEFIEF@EDFIIFBFFFEEB7;B?3@>>>9;AB#
@4Z2
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CCCFFF?DFFHHHJJIJJIIFHIJJIJJIJIIJJIGJJJJJIHGIIIFIIIFIJGHIJJJGIJIJJHGIIEHHF5?ADEEEDDDD<BCDDCDDDDDBDDD#
@4Z3
CGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATCCTCTTCCTCTGCTN
+
@@@ADDDDDHHHDIIGGEGE@?@GGCGGDHHGGFDHICGIIEEIIHIBE@EHIIIGGIEHH?CEE@EB@C>CECA??B>A>@@:>A>CA>A>A>>>:@AC#
@4Z4
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
CCCFFFFFHHHHHJJJJGIJJJJJFHIHIJJJJJIJJJJJJJJIIJJJJJIJJJHHHFFFFFFEEEEEEDDDDDDDEEEEDDDDDDDDDDDDDDDBADDD#
@4Z5
GGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGN
+
???DFFDEGHHHGIIIJIIJIGHHIIHHDFEGIJFFEEHGIGIIFGGHI?FHIHCGGIGAHCHHHFHFDDFFCEDEDDCDDDDDC?@BD?B::ACCDCCD#
@4Z6
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTN
+
@C@DBFFFHFGDHF<EHGGGHDDBHHIIHCGEGH<F>EFHHIIGG>DHHIIIBGAFEBHGIEE>EHFFFDCACDACCCCBBCBB?@CCC@CCCCC(>:AC#
@4Z7
CACGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCTGTGCATCCCTCTGGGGCTATCT
+
@CCF?ADBFFHHDHGGGIIGGGGIJJIGGAD>FGEHGEG;BFDCHGIJFG@HIJJBHHG@CBDF>@A@CACDDCBDDD>@CDECDBCDDDDCB7@DC9:
@4Z8
AGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGN
+
C@CFFFFFHHHHFGGGIIJIJJJJIIJIIJJJIJJIIJJJGIIJIIGIJJFIIJJJJJJIIIIIIIIJIJJJJJHHHHAEFFEEFBCCCCECCDDECDDB#
@4Z9
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGCGGTCCTGTCGGAATGAACTCTN
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJHIIJJJJJJJJJJJJIJJJJJJJJJJJJJHHHHHHFFFEEEEEEDDDDDDDDBDDCCCDDDDDDDDDDCDD#
@4ZA
GGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGCAATCCGGTTCGGCCTGTTN
+
@@@DDD>?DFFF>A9:?:<+<<8??)::?B9:))).)9B)/88=C=@F-@1.))7;A)=?;);;;@(;;@B95;;(-5:@3(,(5(5&5&&+0&55<?((#
@4ZB
GTTCCTTCTCTTCTTTCCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACN
+
@@@DFFFFHDHHDHGGFIIGGIEIIGJIGIIIJIGIIDGHIJJIIIJIIIGIGIJIIIIGIIAGDHGIJCHH>EEEFFDBDEECACCCDEDDDDDDD@C@#
@4ZC
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CCCFFFFFHHHHHIJJJJJJJJJJJGHIIJJJJJJJJJIIIJIJIJJJHIJIJJJJJJJHIJJJIGJHHHHFFFFEEEEFEEDDDDDBDDDDCDDD@CD
@4ZD
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
@@@DFFDDHHACDGGGHIIGIIIIIIGHIIIIGIFHGFIIGIHGEHIGHIIGIIFFHIGIHIIIGGEEEDFFF@DDEAECCCCB?BCCACCCACCCC>CC#
@4ZE
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCN
+
@<@FDADDHHHGFEIIIAFHHIIGIIFGIHFHHGIEGHIEEGFEBAFDHIGICHGGHHGHGCGIIEIIII>EHHEEEFFFFFB;>CEEDDBDB@C>CC@:#
@4ZF
CTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTG
+
@@@DDDDDADFFHIIIBD9CGF?F;??FCEGIIGDGIEHHDBCBFGG>DDG>>CFEADHCEEH<ACDB.75=ACBB@>CC@@>><??ABAAC?A>CB?C
@4ZG
GTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTG
+
B?BFFFFFFFHFHGFHHII?FHIJIFHJJJJJJJEHGIHGGIIEIEIIIJJJJFHGIGIGJJIIIIIGIIIGHHHEECC@DEDCCDDDCC@CDDFEED
@4ZH
GTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGN
+
@@@FFFFFHHHHFHIJJJGJJJACCHGHHIGIJIIJJJIIJJHIIGIIEHJJJJJJIGGJIIIHIJJGHIIIFHFFFEEDEECDDDDBBDDDDD>CDDEE#
@4ZI
GTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCN
+
BB@DDFFFHHHHGIIIHIHHHJFHIJJJJJJJJJJJJJJJJJHIJGIIJIJJJJIHIHHHHHFFFFFDDECEDDDDDDDDDD@CDDEEDDDDBBDDDDDD#
@4ZJ
CTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTCTCA
+
@@@F?DDF@8D?FGGGAHG?@FBEGGC?FHGIDGGIB@7@EHGDCE;>CE);BE@A7@;CEA5=>=5;=@B?ACC>CC@CCCACAACCCCB<?<BC@@C
@4ZK
CTCTGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFDHHHHHJJJIHIJJJIJJJJJJJJJJEHIIIJJGGIJJJJJIJJJJIIIIJIJJJJHHG<AC?CDDCDDDDDDBDDDDDDDDDCCDDDDDD@B#
@4ZL
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCN
+
BCBFFFFFHHHHHJJJJIJJJJIJJJHIIJJIJJJJJJJJJJJJJIIJJIJIFHJJJJJIIIIJJJIJHHHHFFFEEEEEFEDDDDDDBBDDDCDDDACC#
@4ZM
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCN
+
CCCFFFFFHHHHFIIGGHIIJJJDHIJIIIJJJJJJJJIJJJJJJJJIJJJJIJJIHIIHGHFFFFEFEEDD;?B;CDDDDCDDDDDDDDDDDDCDCDDD#
@4ZN
CCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGTACATCTCCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGA
+
?8=DD?D1CDDDD4A3<CC;39AAE3?;E<?<*C?D.06B<B8.=)8;A@;8=.73).7;@9>;6>(;A5(;?=8,8;?>?-905:44:>A38>A<(
@4ZO
GGAGGGTAGGATGGAGGGGCAGGGACTGGCTGCATGGGGAAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTN
+
1:+=40A:CB3?:EEEI)1?E8):):0?D?97788=;8A(-5@.7A(.7(.7?;);A?85,,5>;;>5(>>A>5>:5,,54>:>3>(:((((202<+50<#
@4ZP
ATACATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCN
+
=?+=AB?4?FHFHAC3CF@EHCBFHGAF<@>FHG<CBB<DCFB???BDD>FGB?FGGGCG<CGHGGEGHCEG=AAE?BEDECB3@?>C@CCCCCC:@>:(#
@4ZQ
CTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCN
+
@@?DDDDEFHFHGCGDHGHEHIGGIIHJJJJJJJJIIJJJFHIHEIICHIHGICHGJHIIIIIGIGIIGIIJJJHIIJJGIGGJIFHHHHBEEB@DC>CE#
@4ZR
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
BC@DFFFDHHHHHJJJJJJJJJCHHJJJJJJJJJJIJIIJIIJJJJJJJJJJIIJJJJJJJJJJIIJIJJJJJJHHHHHHFF@DDDDDDCDDEEDDDEED#
@4ZS
CATGACAACATGTTGAACAGATTCCTCCATCATCATAATGGCTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCN
+
??@D?DDB;FBDF:FEGGIIICCE>FE;?F>EBGI@F994C3CBF@3*?0BFCE>F@@FCB))/===>88/.7=@;4@;A97?=BC>@3@;((-(((5;@#
@4ZT
GGTTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
??+=?DEDHFHHFBFHHIGCGBCHIIGEGFGHIGIFIIIIHIIIIIIEGHEG<FHIBCEEEHHDEHIGECEEBDFCC3=?>=838AC:::@CCCCCCC48#
@4ZU
GCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTN
+
@C@FFDFFGF<DDFHIIIFGFAFGGIIIGIIIGIIFHIGA@FHGIIIGIGEGIGAEEHGEDDCFDFFDEEEDEDCACCBDD@9>@C:>CCCCC@CCDDD5#
@4ZV
CCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGN
+
@@8BD?DDDBHF?B@FBDGIBCHEHBG<FECCE@91?BDA>F?FHCH*:??GBDFHB<9BFDHIICGFHE@DGHCEEHEHHHBEHCCDEBBBAACDD;CC#
@4ZW
CTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGN
+
CC@FFFFFBFHDHIIEIEIGGIDGHGICCF??EFECEDGGFHGEHFFG<D9=FHA;BHADB?A6?CDCDCDDDC<A9@>@<?CCDDCDDDD@:AC>ADDC#
@4ZX
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGN
+
?@+ADDDDFHHDBCAFGEIDBCEHDGIIIIHIIFHEGICFGID>G;FFGGIIGG=DHGGHHFEEEEDC;7?;ACC:ACCCCA@C:@ACDDCCCCCCCC<<#
@4ZY
GTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACN
+
@@@DDDDDHH>??GB:AA:<:CBEEHBFHGEB<?CGBDGIHBBHBGBFHDA@@C9@@FHIIHIHEFCBBDBACCCCCCC?C@CBC:AC=;<@BCCCCBC@#
@4ZZ
CTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCC
+
?@8=B?ABFBFFHEGFDHIIIGIIIIIIIEGIIGIGGG@FGDB:BD?BGHGEGGIIIIIII=FEFGHIIGIGGGEHIIEHFHHFEECEECEC>@CCC>
@500
ACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCN
+
@@@D?;=DBFFADC:CFGGEHIFE+<CC?C?FGABFGHEG9<BBBFF>FHIGCFGGHIGHHFH);@@DCCC=692'3:@>>(>?>BBBCCACCC>@C@@C#
@501
GTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTGGGGGTCATAAGAATGAACATTCN
+
@@@D:=AADFDC::?A?CAI<<AFHDB8CBG@EDGIIIF?????BF=<FF68B==F=FGEDF;E;E366AE?BD;;B;66,3,,5@@@:34:4A>:(++4#
@502
GGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
@CCDDDFFGHFHHGGIJJHIGGGIHJGIGIIJJEGHIIJEIIIJIJIIIJHIJJJIJJIIIGH.;E@DHGEEHGHCHFFFFFEEEEDDDCDD?ABBBDD
@503
TGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTN
+
CCCFFFFEFFFHHJJIIJGIIIJJJJIGHJJJJJGIJIIGIJJGHGIGGGEHHGHGHHGGIJIJJJIJCCHFFHHHEEFFFFEDEEEEEDCCBDDDD?CC#
@504
CCCCATCTTCATCCTCAACAGAACCAGAAGGACTTGAGTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCTGCATCTTCCTCCTCTTCCAAGGCCATN
+
:1=+4AD8C>FB8?CGEBFFB:C@?<8BC?DF?FFFF9CA>4?FF3<BFFAEFAA@===AEED;@7CE<>?BBB;A@AAA@BA@@A<?BBBABABBBB?3#
@505
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCC
+
@C@FFADDH?FAFHIIGII<BA@@FEA?FHG@?CDCGGB?6BGFBFH;;@=@@==6A;;?D?A;>CACCB;@=?C>A@>>CC@AA@><<>A@CC:>C
@506
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
CCCFFFFFHHGHGJJJJIJIJJIJJJIJJJJJJIJJIJJJJJJJJJIIIJJJJFHIJEHHFGHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@507
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
=?1ADDDDHHHH8CEGHIIIIIII?FGFGHHIIIIEIIIIIIIIGBFEIIIIIIIIGIIIIIIHFEEEEEC@CADCCCCBBBBBBBBCCCCCCCCCDDE
@508
CATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATGTGCCTCCN
+
@@@FFFFFFGBFF@FGCGICIHIHIGIFHCGGGGIGIIIGIIIIIIIIIHIIIIIIIGIGIGIEHIIIIAECEHHFFDDFF@CEE;ACCDCDCCACCCDD#
@509
CTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCN
+
CCCFFFFFHHHHHJJJJJJJIJJIJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFEEEEDEEDDDD#
@50A
CATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTN
+
CCCFFFFFHHHHHJJJJJHIJJJJJJJIJJJJJGIIJHIJJ?FHIHIIJJJJFHIJJIJHHHHHFFFFEEEEDD?BDDDDDDDDDCDDDDDDDDDDDDDD#
@50B
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
BC7DDDEFHHHFFIHGIGIIIIJJJJJJJIIJJHIJJJJIJIIIGHIJJJIJIJJJHIHHHHHFFFFF>CECEDCCDCCCCCDDDDBDD<CDDDDDDCC
@50C
GTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTG
+
BB@DFFFFHHHHHJHHJJJJJJIJJJJJIJJJJJJJJJJJJJJJJJJJJJHIIJJIJJJGIIJIIJJHHHFFFFFECDEDDDDDDDDDDDD
@50D
GCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCN
+
CCCFFFFFHFHFDHIJIIEHIFHHHGBGGGHBDEIGIJB@BGGGEFDFDH@DHCHGIJJJIIE>@CDE?EEEDFFF;@;.;C>???@BDDBB<@@BDDD@#
@50E
TGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGN
+
CC@FFFFFHHHHHJJJJJJJJIIJIJIJJJJIJJHIJJJJJIIJJJGIJIIJJJJJIJIJIJJJJIHEHFDBDEECDDDCCDDD>CDDDDDDDDBDDBAC#
@50F
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGN
+
@@@DDDDDBD>F?@FGBG<GEG9CFE<BF>HGIGI@F??D@9*?FBG>9(8CFBC;FEC@DEGGHG<AEEBEEEECC6(>@>B>8??@CC>@>C3(44A(#
@50G
CCCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
???DD=BD?DDD>E<<<<FFE7+3A?F@EBBA<EF**))11??DEEEBB?DDDDEBDDD<<BB@BCD=C>A;4)(72@CCCDC;@>@@;>@AAA@AA>
@50H
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGG
+
8==A?B8=DBB;FEF93+<<A:AFF@::000?BD9BF>??C4B=BF))=)=7=(5':?7>@9@A3((;A@3>=3-5>>3;5(((,:@(,3(4><
@50I
GCCTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCN
+
@@@DDDBDFHFHFGIGI?HCBGGFGHDIFGGGGIIGGHGHIIAGGGADHIIII<AEGHGC@@@:?EEB=BDEF?BEEC3>C>AACCCCCCDDEDCCCCCC#
@50J
CTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTN
+
?@?DD?DD?F<4<C?E?C@FFEFII>FEFE?EFHIDFFIIIIFFEIF@9<FBFD<:?DFFEFIIIIIEEIEIECA@E;CEEE=;EEDDDBDD@BA@>BAB#
@50K
GGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
@@7DDFDDHHHDHIEEHGHIEHHIDHHIJIIF?DHGGHIJHGEGBEHHCIIJIIGEGHHDHHFFFDCEEEDEEDDDCCCDCDCD@CB<CCCCC:CAC:A
@50L
GTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTN
+
@@@DBDDEHHHFHFDGGIJJGGIHHIIICDGGGIJIGJJIEGBIGIAEGHGGG@HHJC?EEHFFCCD?CEC:CCCCB?B?CCDDDDCCCDCDDD:ACBBC#
@50M
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@<DFFADDHFFHIIIII@FHBDGIGIGGHBHBHIIDHCGHGGDHIGIIGIIGEHHHHHD@CFEC@CCCECCCACACCCACCFCCACAA<ABBB>@BCC
@50N
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATTCAAAATCTCTGGGTTCCTGN
+
1:<BD;::C<FA>FGEE3CFE>;ECFDFF9EDCFEDF@C<BBGGB@F<*?D38*9D@@B@3@FC3)6.@=;EEEC))7);)7;;>A;AB35>@?((,5:(#
@50O
GTTGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@B+ADDFFHHHHHJJJJJCGIIHIJJJJJJJJJJJJJJJJJIJJJJJIJJJJJHHHHHHFFFFFEEEDEEDDDDDDDDDDDDFDDDDDDDDDDDDDDDD
@50P
CCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTN
+
=@+=B?DBBHHDBFAFEHIDDBGGHHDFHI@HDGIIFIB<FEBFHCHGIG;<(;8A</<>A'5;>@CCDECC?B9>909@C@?CCCCC:>ACCCCCC>CC#
@50Q
GTTGAACTCTGACAGCAGGTCCCGCAGCTCACTCGGGGAGGCGTTCTCTTTCAGCATCTTCACGGCCACCGTGGTGTACCCTGCTCTGCCTTTCAGATGGN
+
@@@DDDDEFHFHHIGGHFGFIIEHJIIIHGGIEFHGHEHIIIJEEBB>CEECCECC@C>CDDD=B@D=BD>B<><@BCDCCCCDA@CCCCCDDDDCCCCC#
@50R
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
@@@FDEFFHHHFHIIIHGIJJJJHGIIIGIIIJGIJJIJJBDHGCEHI7BFGGGHIIJJEHHFHFFFFFFFDEDCDDDDDD=BBDDDDDDDD@CDDDDDD#
@50S
CTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
BC@DDFFFAFFHHIIIIJJJIIHIJJIJJJJGGGIJHHGGGHIIEIJJIJEHGGGGIJHIIHHIEGCHHHFEBFFEDCCEDDDCDCCA@DDDDDDDCC
@50T
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
@@@DFFFFFHFHHGIHIIIHJJJIFGGHGIGGBFGHHIIIGIIIJJIGEIGIIAEHHFDEDFFEEEEEEDCDACCCDDEECDDDDDDDDDDCDCC??CDD#
@50U
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJHHIJJJJJJJJJGHHHHFFFFFEEEEECDDDDDDDD9@D>BDDD
@50V
TAGACACAGCCTTTTGAAATATCTACACACAGGTCTACAAGGTCAACCAAGGTGAGTAAAGGACCATAAAACGTTGCCATCCGGGCTTTACGCAAATA
+
=?=?===AACDDD@E+?CCAB4<CFEFC?DEEEEDD@D>DDB**:BB;1;BB3)/=8BCC4=;A;C7=ACD)5?@2'6>A>@>??6=9>A>83859>A
@50W
CCCATAGCAGCACTCCAAAGGACCATGTGTCTGTTTTAGAAGTGAATATTCCTTCCATGAAGGCCTCTGGGGGCATCCACTTAACTGGCAGCATGGCAC
+
?<<DDDB;FH;CFDFG@FHI>;A;2<?AAG<:?C?FD491:F?9<BGBF<9BG>FE@B/*=8BFB7C)8).'5/=;6>;>CC;@5;:(95,8?C:<@CC
@50X
CTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCN
+
@@@D;DDDHFD,C@CGHIIGH@FG=<A3C<EBGE9?DD>BG4?FHIIDEDHHIGGFACDHHGGHIIII=.5?ECEHB>??C:;;>ACCCBCCB;:A@CD3#
@50Y
GTTGGCTATATTGACTTGGAGCTTGGTTGAGGAACCCGGTTTGGGGGGGGTAACTAGTGGGAGCCTGCGGCCAATAGCTGTTTTGTTGCCCATAGTAACCN
+
??:ADDEFHHHHHIIIIICCDGH@G+222+*1*)):0))@D?DDHA'5<-&5+(((++3?+(2&((((&)09&((+((+++4@3+<+((4(((++(((((#
@50Z
GGGGAAAGCAGAGAGCATCAGAGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTCAGA
+
@@@BDD?D?HBH?DDHCBCGGBFGG:C@GEGDGH>E?EGHEGIGGHIEFGEF3=FGGEDA=37=?A,;BBCEAACCB<C?BB8<90>A<C(9<>9<?CC
@510
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCN
+
C@CFFFFFHHHHHIIJIJJHJIJJJJJJIGIIJIIIJJJJJJIIJIJIGGHIIHIIICGGGIDHIJHHHHDFFFCDEDEDDCCDDDCDB@BCCDDDDDDD#
@511
TTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCN
+
@C@FFF@DHHFHHHIJJGHGIJIIIJJJJJJJJJJJIIJIGIIJIJJJJJIIJIHHHHHHFFFFFECEEEEEDDDDDDDDDDDDDDDCCDDDCCDDCDDD#
@512
GGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTGCTCCTAAAAAGACGAAGAAAAATAATN
+
?<+=+:BDADB>:E@EEE?;E;?81CCD;D>;9D2BAD*8**?;;C;)7=@A>AA<9?>@;@@A==>?(59,,(((5:>+::34&2309;<;A?<<1:3+#
@513
CTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATCCTCTTCCTCN
+
CC@FDFFFFHHCDFHJJJJJIJJJJJIJIJIIIIJJIGHIJIJJIIIIJIJIIDCGGIIHHFHFFFFFCCEEDECCDCCCCB@C5;@:@@>:>>CCCCDC#
@514
GTTTGCACATAGTTTAACACATCAAGGTTGGAATGAGCTGGATAAGGCTGATGACCAAGAGTTAAAATCTCCCAAATCAGAATTCCAAAAGACCATACATN
+
=?@DDDDBFDDHDCGHGGIGIIIAHH<AECFEBFE>DEACHG@BBFBDDEBA8BFHIIEFGHHGHIIEGBGGGEEFHCE>CECD?ADCCCECC?A@CCCC#
@515
GTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTT
+
@CCDFFDFHFHHHJIJGIIIGHIIJJGIIIJJJIIGHHIIJJJFJJJIIJJGIIJIBFGHIGGIICHIHIGHIFIGHEGGHGEHFFFFFCEEDFECDEE
@516
AGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGN
+
CC@FFFFFHHHHGIJIICHHIJJJJJIJJJJJIIGJJJJHIJJIGGGGIJJJJJJJJJIJJIIIJJJGGIIJIIJHHCDDACEEEECEECDDEEDDDDCD#
@517
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
CCCFFFDFHHHHHGHFGGIJJJJJIJJJJJIJJIIJJJJIIJJJIEIJJGIJGIIJJJIJGHEEEFFFF>BFECEECEDDDDDDDDDDDDDDBBDDDD9@#
@518
CACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGN
+
CCCFFFFFHGHHHJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJIJHHHFFFFFEEEDDD?@DBDDDDDDDDDDDDDDDDDDCDDD#
@519
GAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTN
+
CCCFFEFFHHHHHJJJJJIIJHIJJJJJJJJJHHJJJJJIJJIJJJJIJJJJJJJJJJJJJJJIIJJJJJJJIEHIJHHHGHHHFFFFEFEEEEEEDDDC#
@51A
TGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCN
+
CCCFFFFFGHHHHJJIJGIIJFHIGIJIIIIJJGHIJJJGGIJJJHGIIJICHHHJIHECEEDFFF;ACDCCDCDCCDCDC>CDDDDDDCCDEDDDCDDD#
@51B
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGN
+
<@<DDFFDHFGDFIHHGBFHIEHEHEIGG@DGIEGEFGHIIIIIIHIFGBACCFCCHGA9BBCC>BCCC;;;ACDCDAC>::ACCDDCADDD<>>CDC>:#
@51C
TAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCN
+
CCCFFFFFHHHHGJJJIGJHHJIJJJJJJHHIJJJIJJJJJJIIJJJIIHIJJGJJJIJJJJJIJIJJJJJJJJJJJJJJJJJJHHHHHHFFFFFFFEDE#
@51D
GTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGN
+
@@@DBDFDFH?DBEEIEGDEHHICFEHHGFHIIIIIIIIFGGI@DFFHHIIAAD1B=GGBC=CHIGIIIIIGHCCHHHHFFFFDDFECCCDB@CACDDDC#
@51E
CTTCTGTGTCAGGACTCTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACGCTGCCACTGACGGAAGTTCTCATAAACGTCCTTGGAAATTTTGGAGCGN
+
@?@AD?22==:<FGI;GCI@E?GC?G2CFG>?C?08??B???8?BBFFFC=FFFAE>?EFEBD?CC=;A;A;>35>;>55598<BA>:ABA@BA>5ABBB#
@51F
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCN
+
CCCFFFFFGHHHHJJJJJIJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJIJJHIIJIJJIJJIJIIIJHHHHFFFEEEEEEEDDDDDDBDDDDDDDDCDD#
@51G
CATCAAACCATTCCACGGCAGCCTTGGCAGTGGGTGGGTCTTCATAGGACACTGTGGCATCGCCTTTGGGCTTTCCTGTTTCCTTGTCCAGGTAGATGTGN
+
@@@BDFFBDHFHDEHG@@F<AGHIIGGHGECGGH:@E@GGEGFEGHGCCEDE@E?ACEHFFFBDDDD>CDDCBDDDCCCCCDCDDC>CCDDD:@3>AC>@#
@51H
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGN
+
:?+A;A:BFDDDFE<E:<FIC<EGCC@F9+<AFFE?F>F3*:?:D))0?DBF?=B/=8@7@CC@@)=@A7?>E.7A)7;@;;>>A>@>ABB@A>BBB?5,#
@51I
CCTGTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCGAACTGGGAGTGCN
+
;??ABDDBFAF;:A@FGHGEHHG<?:AAFEAFGH@AH<F?FHCH4BDDHB0?FEHDCDBB;;2;9;C6;CCA7?;=CEC@3>>CCC3>;==<>>@??8<>#
@51J
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATN
+
@@CFDFFFHHGHGIJEGHIEIGIIJEBEGHCHEGGIIJGJEECG@DFI<FGGIIJIAECEFBCECEEEDDDCCACDDDDBBDCCCDDD@ACDCCDBCCDC#
@51K
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
<@@FFDDFFHHHGGGEGGEEFHHGJJJGIGHIGGGHIJIJIIIJJIGDEHGGIGIGIEGIIDHIGIIIFHGFCB>BBACCD@C>AC@BCBACDDA4:A?
@51L
GCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTN
+
?@@DDDDDAF>H<ACCEE?A33<CHD3AACGII>GDB?9::C<0*B<;9B1(?:@F@BGEDHC)=DG>G3=A???@@.7;AD>;@@A@35;AC>>:A@>C#
@51M
CCTTAGAGGGCAGAATGGTCTTCACATTAGATGCTGTCACAAATGGATGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTCGAATTG
+
:8+AB2A=D<??AFACACC<<:CFEB>H94??@FEA<DDD9<FGA9**00949?D7BAE)=2))).6=@CEFF6655',6.;>>>BB-&59>><8(<A
@51N
GCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTN
+
CCCFFFFFHHFFHIIIJJJIJJJJAHHHJJIIIIJJGEGIIJIJJJJJJJIIIJIJJIJJIIJJIJJJJJJJJIJJIJIIIJJJJJEH=BDFFFEEEEEE#
@51O
CCTTGAGGAAGCACTCCACGACCCCCTGTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCA
+
CCCFFFFFDHFFHJDHIIHHGIJJIJJIGHI>?DFHIDHJIJJJIIIJIJIIGGC=EGGFHHHHEDDBDEDEC@>CCCCCDA@CB@BDB?DADCDDDDA
@51P
TTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTCCATGATGTCAACATACTCCTTCACAGCTTCTGGTGGGATCTCCTTGGGTGCCTN
+
<@@FFFFFGDHHHGIGIIJFCEFGIJCFFHJEDHIJIJIIHII@HDGIFGIJG@B@CACCGGHGHICCCEHCHHEFHFFF@DDDD@BDDDDDDDD@BB?C#
@51Q
TTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJHHHHHHHHFFFFFFEEEDE#
@51R
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGN
+
@@@FFDFFHHHHGIIHIIJGJJIJIJJGIJJGIJJJJJIJJJJJGIJJJJIJJJIJJFIJIJJHHHHHHFFFFFFEEEECEDEEEEDDDDDDCDEEDDDD#
@51S
CTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGTACCTCCTTCATATTGGCAGTC
+
C@CFFFFDFFHHHGGHIJJJIJJIGGFFFGEGIGIJJEHIIJIFFHGEHGHIEHICHGIGEDH>CEE@CCDBCCED@AACACDDDDDEDEEEDDCBCC
@51T
CTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTN
+
@<?DDDD@@<<@:CF>BHGE;?GEHIDF?FGFB@DGCH@DBFCC=@G@EHHHHABDDBDC>ACCCCCCCBBCCACACCBBB?C?CCCCCCCBB&09BCC3#
@51U
CACCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGATATATTGACTTGGN
+
@@@DDDEFHHHHHIIJJIJIIJJJJEIGGIGJIIJJIFDGHFHIIJGGHIIJJJHGHFHFFFFFFEDDBBBBCC?CCCDCCCDDCDDC:ADDEEDDDDDD#
@51V
GCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTN
+
C@CFFFDDHDHFHIJJFGGIIIIIICHIGIJJGIIJIHGGGIIJFHIJJJIIIGEIFIJHHHEEEDDBEEEDCACEEDDDCCCCCDDDDDDDDDDDDDEC#
@51W
CCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCN
+
@CCFFFFFHHHFHGIJFIJJJJJJIJJJJGGIJIJJJJJJJJIJIJJJJIJJJHFDDDDDDDDEEDDDDDDEDDDD5@BCDCCCDEDDED>CCCDCDDDD#
@51X
CACCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTTTN
+
@@@FFFDDBFFFGIIIIIIIGEHIGHIGHIIIIIIIIIIIIG>G;FIIIIIGIIBFGEGGICHIIEEGGFHGGIE@DEEDEAE3?EE>BDCFDEEDDDD@#
@51Y
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
CC@DFFDFHGHGGJJJIGIJJJJIJJIIJJJJJIJJJIJIIGEIJEGGIJIGFGHHFFEDDEEDDDDDD;@CBB@DDDCDDACCCCCDDDDDCDDDCAC
@51Z
CTTCAGCAATGCAATGATATGTGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGN
+
C@CFFFFFDBFDHGGGIGFGGDFHIGJIIGEFHCDGDFIIHIGJIGHGIJJIBGGHIJAFHIGICGGHIGGHEIEIIJDE?CEEH>DBFDAACEDEDCCC#
@520
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@@@D?:DAFFDHGIIIIIIIIIIIIIIGGII@@8@?F?BBGBECCFHIGICGGH@<>BCBCCC;>@CC@CAB=@B7C@:::CC3>>B>C>>::?BC?3>
@521
GGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGG
+
CCCFFFFFHHHHHIIJJJJJJJJJJJJJJJJJIJJJJJJJEHHHHBDEFEEEEEEEDDDDDDDBDDACDDDDDDDDDDDDDDDDDDCDD<@BDDDDDDD
@522
GTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTN
+
@@CFDEFDFHHHHJGIIGIIJII;FGHIJJIIJJIJHIIGHIGHHE>FHBFHIIGIDFGIJIJHIDGHHFDEEEFEEDEECAC@BDBBDCACCCCACDDD#
@523
CCCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
;?<?=8@DHDHHFCFBEGCHDAFGEGB@@GHGIDCG<F@GHGIIGHID=FHGDGAEH7AE>;@DDB3>B;:>@@>@?>B@B>ACCCCCC@C4:28.9B<(#
@524
TGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
@@?DD==?=CBDBACGBDCD<AEEEHEEEFEGAEH?EDD;FDBDFEGIDD??BFG@@BFFCHC=CHGHDHIIGCEEAEH;.9>9A>?>A>>ACC@ACA>
@525
GATCGGAAGAGCACACGTCTGAACTCCAGTCACGTGAAACGAACTCGTATGCCGACCTCTGCTTGAAAAGAATTCTTTGCAGCCTTGCCAGAGGAGGCGGN
+
?;?B;0+2<DA:<A;E:<A3<<2C<E91111:C?0000B9B8(7BCD.;=)))-''',;@DA3((((((((,(,(,5>>:>>>??AAA>:48><8<;(09#
@526
GTCCAGTTTTGTCTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGGGCAGGATGGGCTTCAGCTAGAAGGCCACTGATG
+
?::+4=2A<AD<A<:<CAFF9AF4CC8<AF>9EEEFEF3DE910?<:DD?939D38/9DE8B)=).-8;A@3);A>@?77?;(6(.66=;5(;3>(,:
@527
CCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGT
+
CCCFDFFFHHGHGIJJGHJIIIJJJJGHJJJJJIJJFIGJJIJIDEHJIJJJJIIJJIJJIHHHHFFDDDDCCBDDDBDDDCDDDCCCDDDDDDCCCB?
@528
TGTAACTGCTGAGGAGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCA
+
???DBDDDDDDD>7+<CEF<+ACBEE@FFIIEDEA?CDFAB???B?@@*?DDEEBDDIIIIDEEEEE@ADA@CDEEED;AC@CDA;;>@>AAAAAAAAA
@529
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@??DDDD;BFFHDHGBAHGHHIIEI+ACFGE<EHGB>?CFCGIIGIG??FGGIIIEHIIGHGGBAADC>C@CCCA>@AB9?@BBBBCCCABCCCACCCCC#
@52A
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGGGGTATCATN
+
@@@DDDDDAHHBHIG>GHIIIGGI@BCBEEEDGBC?@FHGIIIIIICEGG@GDB@GGHHGG@FHG=GFEF=?AACCBBACCC:>>C@C(:A(5<<@ACDD#
@52B
CAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGG
+
CCCFFFFFHHHHFIJJGHIJJJHIIJJJIJJJJJJJJJJJJJJJJJJGHJJJJJHHAHHFFFFFDDEEADDDCCBDDEDEDDDDDD8ACDDDDDEEEDD
@52C
GGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGN
+
@@@FFDDFHHHHGBGHJGDHIIIJJGHHI@HD@GGECHFH9<BBFGHHGGIIJGIGIGHIJGIIJIJHDFFDD@;@C>CE;A@CCDCC@ACDDDDCCDC@#
@52D
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CCCFFFFFHHHHHJJJFIJJJJIJJJJJJJJJJJJJJJIJJJJJIGJJJIIJJJJJIIAEE=AECEECBDBDDDDDCDDDDDDDDDDDBDDDDDCCCDCD#
@52E
CGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCC
+
CCCFFFFFHHHFHIIJJJJJJJJJJJJJIJJJJJJGHIIJHIJJJJJJJJJJJJJJJJHHHHHFFFFFEEEEEEDDDDDDDDDDEDDDDDDDDEDDDD
@52F
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCN
+
@@CFDFFDHHHHFHIICGHHIIIJJICHGIHIFGHGIGJJJIIJJGJJJJJIGHEADDDDBDCCDDDEDDDDDDBBDDDDDCDB@DDDD??:ADAC@CCC#
@52G
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
B@@FFFFFGHHHHJJEGHIIIJJIJJJHIIJJJJJJIJJIIJJJIFFIIJI?DDEDEEDDDDDDDDDDDDDDBDDDDEDDDDDDDCDDDDEDDDDD@C
@52H
GTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGGGATTTGGGCTGCGTGCAGACGACGGGGTTGGAAGCCTGCGTC
+
@@?DDAD=CDHFBFGGGBGFIIEIIIEFHHEE<EHII=FHEHIIIIDGGHGI;FHHGH;BHHEHFFF@CB>>BACCB@=@<BBB5<BBCCABCCCB<5@
@52I
GCGGGGGACGTTGGGGTTGGGGTAGGTTCCCCACGTGGGGGAGGTCCAGTGTTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGCCAGGGATGGGGGATN
+
@1?AADD?)8?7;=;@@@B</456=,>>;((,(,3,9<;:7-&&++88@9(+3?98:@(+)0&)&+:9(3((3(44?@8?02<++(+44<&2388(8.55#
@52J
GATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTA
+
CCCFFFFFHHGHHJJJJJIJJJHJJJJJJJJJIJJJJIJJJIJJJJJJIIJJJJJJJJIJJFHIJJJJJJJJJIIJHHHHHHGFFFFFFEEEEEBDDDD
@52K
AGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCN
+
CCCFFFFFHHHHHJJJJJJJJHHJJIJIJJJJJJJJJJJJJJJJJIIJIJJJJJJJJFHJGIHBHEFFFFFFDEECCEABD>CDDEEDDDDDDDDDDDDD#
@52L
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGN
+
@@@BDDBDHHAHHIGGGBGFF?FDGGIHHGIDF1CFGEGGIBHC@DHGGDFHGICHIIHGE>=??AEECDDDFCCACEC6>A?3>@B,5<@:ACB?AB(2#
@52M
CTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCN
+
CCCFFFFBCFFHFJEGBGHGHJHIJ@FGGFGEEGGJIIGGGGGGHHGBEEEHDD?ACBCCDCDDDDD@CCDDDBDDDDDDDDDDDDDDCCBDDDDDD@BD#
@52N
CCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTN
+
CCCFDFEDHHHHHIGAGGIJJJJIJIGHJIJJIJGHHGIDDB?@DHCFHBGGCHGFIIGGGIJAEGCA@=ACHHHC?@DFDEEEEEEEDDDDDDDDDDDD#
@52O
GCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCN
+
CCCFFFFFGHHHHJIJDDDDDDDDDDCCDDEEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDCDDDDDCCDCCDDDDDD#
@52P
CTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTN
+
@@@FFFFFHDFHHJJGGIJFIIIGGIDGEDGDHIDGHJJGIJIBGHHDFHJFFHI@FHGIJH5AEHF@DFFFCAACBDCDDDDD8?BCCDD??CD:@CCC#
@52Q
CTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGCTCAGAATAAGAATCATCAACACCAAATTCTN
+
@@@FB?DDBDFHDIBGFDHEFGHIIIIIIIIDHFFEGGIGHHDHIGGDDFHBFGGCEGIHGEHCHIEGGDAEHHCEDFFF@@AEECCCECC@BBABCCCE#
@52R
GTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATGTTGAACAGATTCCTCCATCATCN
+
C@CFFFFFHGHHHJJIGIJHIJJJJJIJIIJJJFIIJIJJJJJJIGIJJJJJJJJJJJJJGIJIJIJGGHIEHGHHHEHFFDFFFECCCEEACDDDCCCD#
@52S
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
CCCFFFFFHHHHHFHIJJJJJJJJJJJJIIJJJJJJJJJJJJIHHIJJJJJJJJJJJJJJJJJJJJJJIJJJJ?EFDEFEAEEEEEDDEEDDDDCDDDDD#
@52T
CGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGN
+
CCCFFFFFHHHHHEIIJJJJIJGJJIGIJJIJJIIIIGBH@GGEDBDHIIIJDGDH>@CFEHIJECHIGCECEADFFF@DCCCDCEEDDDCDDCDB@=@B#
@52U
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@C<DDDFDDFHFHJJJJGBFHHJJJEFGIJJEGDGGFHIEHIIIAF@EEGEHCHFEF<AAA@@EDA@C>CC=BBDDDCCD>CCCACB@CCAACDDCACD
@52V
CCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACN
+
@CCDDDEDDAHFDCC@@@DGIGGGE<FH@FCE;@BDDFGDDHIIIIGGIIFHEGGGHGDBDHGGGAFDAC===@EHH;AEFE@EFFEEDDBDCDDDCCCC#
@52W
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFFFFFHHHHHJJJJJJJJJIIJJIJJIJJJJJJJJ@GHHHIJJJJJIHIJJHHHHHHGFFFFFDDCD@DDCCDCCACDDDDDBDDDDEEEECCDDDD#
@52X
CTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTN
+
@C@DFFFDFHGHFJJJIJIGGGGIIEIJEGGHGIIEDFGGIJJIGCGIIIIIFHHHHHGHBHIGIGGGHIGHEA?EEEFFFF;@CCCEEDB@BDBB@<>5#
@52Y
GCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATN
+
CCCFFFFFHHGHHJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIIJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFFEEEDEDDDD#
@52Z
CCTCTGTCATGTTGCCATACTTGGTGGCATTCTGCATGGGCCCCTGGGGCAGGGCTCCCATGGGCAGCGCCTGCATCAGCAGCGGGGCGGCCATGCGCATN
+
1?@DDDBDDDHDB@FEBDC;FFHI<FEGGIIGC<CB??FGFEHF@D2?AD6;@@CA@DECAHFFEC>B3=>/;<?:CC>:@B@B<50&)&55594>&509#
@530
TCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATN
+
??@BBDD>DD?CFHGI;CFHHHGIIGG<@4AFEFBF?EEHI@>FGGDEDHA9?BDDGGGEE@GHCGG;@;@FH;>EC?E;?A??BCD77@@>ACD@C@C;#
@531
GGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTN
+
CC@FFFFFHHHGHIIIIIIJEHIIIIJFEHIGIJJJJJIIJGI1=>FFHHIAFGGGJIGHBFFDDDEEEDDDDCCCDDACDCDCCBADCDDDDBDDDDDD#
@532
CTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTN
+
@@@AADDD?HHFFHIIIIIIIII<HHGEHIBGHGHIIGHGEGIEHGGDFGGHIIGC.=FGIEHEG>;;;3??BDCC;@BDDCDCACDDD@@D@C@C??@D#
@533
GCTTAGGCAGAATTCTCCTCTGAGCGATAAAGACGACATGCTTCCCACTGAACTTTTTCTCCAATTCGCGTACTAGCCGGACTTGGATTTTCTGGAA
+
@@@ADABDCCF>FFIII@CFHIE>G:???CFHG?CD@@GH8BBFGFHIIIEEGIHFIE>EA@@??CE59=9;:AC@?<?B8<>CCC:AACCC:A@>:
@534
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJHJJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJHEEEFEEEEEEEDDDDDDDDDDDDDDDDDDDDDD#
@535
GTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCN
+
@?@DDDD?FDHDBFEGBFGBFF?FGFGFDHGDDDHIEFD9?BGIADHF/BFGEGGGHIG@FHIGGG@C;?=7?E@CCA66@C@@CCCCCBBBACAACCC>#
@536
CTCCCTTGGGGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAACCTGGAGAGTTCCTCATCCTCTCCCTCTGCTTCCTTTTTCTTTTTCTCCTTTCCTN
+
=?+=BB4:++<+0)AC;39AFGGEDG3:DFFFF=F)00?B?8**?((..((87@).)7C>;?>=?;))..(6>66>@;-5>AB@3@((5((,::@ABBA(#
@537
CCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCN
+
@@@FFFDDHGHHHJGAEGEFEFDHHIIICFIIIJII:DGCHEHGDBDGAEEEDFFE@CEC>;AED?=?CCCBDDDD?CDCDDDCDCCDDD::ACDCEDEE#
@538
GCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGGACAGGTGCCTCCGGGCCAAGGCTTTGT
+
=?8?DDDDBD:FAFFFE@DFEB>FGAB@D@FEIII@<BFF@FFIE=DEEFFFFFFDB7@BDDA@6=@>B>@=;(55?,555:>?B@<@BBBBB@B?BBA
@539
CTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGN
+
CC@FFFFFHHHHHIJJIJJJJJJJIIIJJJJ?GHGIJJGHIIIIJIIJJJJJJJGGHHHHFFFDDEEDDDDDDDCCDDDDDDDEEEDCDDDDDDDDDDDD#
@53A
GGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCCTTCTGTTGGTCACACATTCCTCTCATGGAGAGTN
+
CCCFFFFFHHHHHJJJJIJJJJJJJIJJJJJFHGIJJJJIIJJJJJIGGJIJJJJJJJJJIJJIIJGHJHGHHHHF?CDEDEDEEDEDDCDDEDDCBDDC#
@53B
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATN
+
B@@DFFFFHHHHHIFBHIGHJJAFGIEHIJIIJDGIJJHIIJJJIJIIJJJJJJJBHIIHHHHGFFCFFEEEEDDBDDDCDDDFDEEEDDDDDDDDDEDD#
@53C
GTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTN
+
@CCFDEAEHDABFE9EGHGBC@<CHIGCDBF?+CEEFHGHAGI<BG?*?BBDGHBGG@EGHIHIIGGGIBEGGHG3@GGGC;C@CC3??>@CE?A<9>B>#
@53D
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
;?;ADDDDFDAC;E+AEGDEHHIHG??CDECDD?>GG?HHFEIGGI?@FHC9@=@H3@@A@>CHAEE9;<A6@A;>>;3@@AACC35<5:>A:::9AA
@53E
GTTCTGTTCTTATGGTTTCCCCACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTN
+
@@@DADDFHHHHHJIEGEIIJJJIIJHHEHIJIIEIIJGGGGIIJJJIGJJGIJJJIJEFHHGGFFFFFECEEEECCDCDDDDACDB?BDDDDDDECDBA#
@53F
TGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATC
+
CC@FFFFFGGHGGGEIIIJJGGIGHIIIJJIJGIIIHIIJJIIJJJIJJFHIIIDIIGJJJJIIFGGHHHH@DCCDD>BCCDDCDCDDDDDC:?B>ACC
@53G
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
CC@FFDFFHHHFHJIDIIIIIIBEDEABFEEGCDFGGIIHI9B?BFFGIF2BFGEHCEHGIIHGH:>?CDBEED@;;CCDCCBDD?A?,:ACCCDDED
@53H
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
@?7DDDD;DBFDHEIIGI@EEDHIIEIECEDHE>FFHE?FGFBFCCFEHEFECGGGIIEECEEHEB?@CCCC;>@C?>'380:>CCAC@BBB@CCCCC>C#
@53I
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
@@@DDDD>FFFHBHIC=FDHIGIGCDHIAGGHCG@GH@GGIBCCGBG@?=AAAFH7@@HH@GADHI@E>?EABDEEE;A>ACCC8;55?AB?BB5?@>B
@53J
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
@CCFFFFFHFHGHJJJEGHIIIJJJJJJJIJGIJJJJJIJIJGIJJJJJJJJIJIJJJJJIJJJJGHHFFFFFFEEEEEEDDDEEEDDDDDCCDEEEDDD#
@53K
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGGGGTGGGN
+
@=?DDDDDHHFHFIEBGDG@GDAHGA>FCGGGE@ACCCCDBFHE>DBF@DDG:BA<=7@DCEE;;C7=?>CCC>@77>>>33@C>?B55>?BB'5<59@&#
@53L
CTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGN
+
@@+ADDDAFFAFFGHFHIICFAHHEHIEHIIIHHEGGIIIDGIIIIIEIIIHIEGA@EDED9@@B@CDC@CCDDDDDDDDDDDDDDB<BBDDCDDDC@BC#
@53M
GGGGTCGCCTAGCCAAGAATGTCCAGGTAGATTGGGGTGGCCTTCCCCAAAGCATGGAGGATTTTGTAGATCTCCTTGATGTTCAACCGCTGCTGTGGTTN
+
=?<?=@DAFHGHD@BAFCGGHCDFFGB*?C99DDHGA8?;=FHIEFDECHIFCHFED@DB5>ACCCBC>>ACDC@CCCCCC>@DCCC?@<BB>C449ACB#
@53N
ATGCAGTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGN
+
??@7BDDDBFFHFBGEGH?C@BFGGG>F@GIFDG9DDF<BGA<B?BABFHGC@CHI9CBFGGGGHGA@HCEEC<?D<A?==C>>AC:5:<@BBBBB?B>C#
@53O
CTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGG
+
CCCFFFFFHGHGHJJJJJIIJGIIIFHFGGG@DGHIJHIJIGGJHGJJJIIGJJIIHH?EEFDFFFCED>BDDDDCDDDDDDDDDDB@BBDBDDDD8AD
@53P
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJIJJJJ?GHIFGHIIIJ=DHIIHHFDDDCEEEDDCCCDCCDDDCCDDBDDDDDDDDCDDCCCAC#
@53Q
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGN
+
CC@FFFFFGHHHHJJJJJJJJJGIJJJIIJJJJJJJIJJJJIIJJIJJIIJJJJJJJIJJJJJJJIHHHFFFFFFEFEEEEDDDBBBDDCDDDCCDDDCD#
@53R
GGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCN
+
@CCFFFFFHFFFFIGJIGHJHJHGIIJIIJJCHIIJJJJJJIGEGHGFHIIIIIJJHIJCHHIGCDGGEGHEE@CGGHGEHGHHEBDBCEFFDEEDCCDC#
@53S
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
:81ADDBD:D?FAGH<E<EHDDHGIIGDGBBAGH9DFA<?DEFFG<FHGHIIFGGICGHH7?ACHEECB>C;>>>CCCBBCB@@>>>@CC:@CC>B@>AC#
@53T
CTCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
@@@AD?D?F;?FFEB<:<EHF@G;CHA?H@HII?G49:C999:?DCFF40??F;FEF<?F@8BBFFA@;@;@FED7@@7)7?CCD@B77?AAA3@>@@;
@53U
CTTATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCN
+
@@1BDDFFHHHHHJJJJJJJIIJJJJIJJJJJJJJIGIGIJIJIJJJJJHHJJJIIIJJJJGIHIJJJJJIIIJGGIIHHHHHGFFFFFFEEDEEEEDED#
@53V
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCN
+
CCCFFDFFHHHHHJIIIJJJFEHJIIJGGHIIDHIGHHGHGBHGIIIJIJJJJ@EGEHIGHHHFHFFF;CEDCEDBCCCDDDDCCDDDFCDCDDDCCCDD#
@53W
CATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGN
+
CCCFFFFFHHHHHJJIJJJHIJJJIJJJJJJJJJJJJJJJJJJJJJIJIJJJIGJJJJJJHHHHFF@CEEEEDDEEEDDDDDDDDDDDDDDDDDDDBDDD#
@53X
ATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTN
+
CC@FFFFFHHHDDDDDDDDDDCCDEEEEEDDDDDDDDBDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDCDDDCDDDDCCDCDDDDDDDDDDD9#
@53Y
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
:?+4=BBDFFA?;FF@FFGCFII:EED<0?DGEEF<FCF<BB=4=@F>DFEFFAECA>@@>>@A3(;>3@B(55;>>;>:(((:>:?3(4?<9:?1(>A
@53Z
TGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACT
+
?<@:DDDD<DFFFHIIIIIDHEEGG@ACEFCEAHB@GEC??>DGGIGHIIIDADFG;CCCFGGE7@7CDHHHHFHBCC?@>6>;6@ACCC@@CC@>:C
@540
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@@FDFDFFFHCFHBBEF3@FG?BC@BDFHGEIGEHIEDGHGHG@FGIEGGIHEHEFHHDFFFFCE@@CECC@CCCCCCAAC@@CCC@C>>?B?>BBAC
@541
CTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGG
+
CCCFFFFFHGHHHJJIIJEHIHIIJIIJJIJIHIHIJIJJJJJJIIJJJIJJIJHIHH?EFFFDFFEDD@DDDDDDDDDDDDDDDDDDDDDDDDDDBDD
@542
AGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGG
+
CCCFFFFFHHHHGHIJIIJJJJIJJJJJJJJIJJIIGJIJIJJFGI9BFHGGIJJJJIJJHHEHFFFFEEEECEDCDDDDDDDDD5>@AB@BDDCDDDD
@543
TCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJIJIJJJIJJJJIJJJJHHHHHFFFFFDD9?DDBDDDEDDDDDDDDDD#
@544
GTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCCFFFFDHHHHHGIJGGIFHIJJJIJIJIJJJJIJJIJIJJJJJJIIHIIJIJJJJJGJIIJJJJJJHHHFDDDDCDDDCD@CDCDDEEDDABCCCD
@545
CGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACN
+
@?8DDDDDHFFDFGIGGHIHGIDGGGGGEG?GGIGGGB>GH?GIGGIHFEIFIEED?BBE@@CCA;A@>=@?;A>@A@CDCA@2@CA>>>?A@CCADCCB#
@546
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CC@FFFFFGGHHHIJJHIHIIIJJIGGJJJEHIJJJIIGIHGIIFIIIJJJJHIIFIJGGI;DG@DHFHGHHFFFF;CED@CBD5>?B@@CDCDD<AC
@547
CTCTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTA
+
=?+=ADDFGHGHHIJJJJJIJJIIJIJJIJJEIHIIIJIHIIJIJIIIJJIIJIGIJJJJJJJGIIJGHHIGHHIJJJFHHHHGFFFFEFFEEECECDC
@548
CTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGN
+
CC@DFFFFHHHHHJJGIIJJJJJJJJJJJJJJHJJJJJJJIIJIJJJJJJJJJJJJJHFFD@DDDDDDDDEEDEDDDDDDDDDDDDDDDDDDDDDDDDED#
@549
CCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCA
+
???DD8DDDDDDD:CE?C>?+<CFB)A+@CE>D9:9D:*?DDE9BD3?DCDD<DECDC@CCECCDD<@C@ADD;C=....77...;@;;>@BDB;;(
@54A
GGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJGGIJJHIJJFHIIJHJJIJJJJJJIJJJJJJJJJJJJHHHHFFFFFEDEEDDDDDD@CCDDCDDDDEDDDCDDDDDDD#
@54B
CGTTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCN
+
?@:DDDDDHHBHFHGHIIGG?FHEGHIIICHHIIFCIIIIIIIIIICGGGCGIGGGHIICFGHGIIEGGHEGCD@CE@EGIGEEE=EEEEDEBDECCCC@#
@54C
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
=@8B??B?DFHFFGFCA<CAC;AACAAB?GDD0?GD7B?B<=B8=@F;C8;=A==ECEDD@@;;A@@;CC55;?@CCA:C>:;>CA:4@44:CACCC>CC#
@54D
GGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTGGN
+
B@@DFFFFHHFHHIIJJIIJIIJIJJHGGHFIGIHIIJGIHIIJIJJJJJJIJJIJJIJJJJJIGHHHGHHFFFFFFFEEDEDDDDDDDDDEDDDDDDDD#
@54E
GATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCN
+
C@CFFFDDAFFHHHHGIJHGEHIIJJJIIIHHGFGGIIJIJFGGIGGIJJGIIJIJJHIEHIGGHFHHHHHFFFFFFDEEDEEBDB@CBD?CB=@CACDD#
@54F
CACCAACAGCCTTAGAGGGCAGAATGGTCTTCACATTAGATGCTGTCACAAATGGAGGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTN
+
@@<DFFADFFFHFIIHGBDHHIIIGIGGGHIGIIIIIIIIIIIIIIEGFHIIEGIIIIFGHIIFIIIHFECD?@BFEEDDCDDDD@D?BDCCDDDBDDDD#
@54G
GTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTN
+
@@@DDFADDDHGFGEHDHAEGEGIIJIIFBEG@HAHIIGIHGHIIJ)@B<BCD@CDD@CCDEEDDCA4>BD@?DDDABD0<9A:A@CCAC>>CCCC9A2>#
@54H
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGN
+
CCCFFFFFHHHHGJJJJJJIJJJJJJJJJJJJIJJJJJJIJJJJJIJJJIJJIJIJJJJJJJJJJIHHHHHFFFFFFFEEEEEEEEDDDDDDDDEEDDDD#
@54I
CCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTACCCGTAGCTGCTGCTCTGTTN
+
?@:BDDFFHGHHHJJJJJGJJJJJJJJJJJJJJJJJJIIJIIIJGJIIJJJJJJBHHFFFFFEEDDBDDDDDDDDDDDD:ADDDDDDDDCCDDCDCDDDD#
@54J
CCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTN
+
@@@FFFFDDF4AFF@GGFGCHAHCAD@HHHEDB>BHCB1::CFA???DGHBFHECFGBG8@CGGGG=D;CHHHGHEHEH@7).;?;>?@C3>>>@:>ACC#
@54K
GTAGGATCCAGTTTGGGGTGGGTAACTGGGGGGAGGCTGCTGCCCATAGCTGCTTTGTTAACCATAGCTACTCTGCTGCCCATAGCTGCTCGGTTGCCC
+
@@7DDDDDF?F?DFGHH:3@G:8??B**0)8D50:&28(++3>?<@8>(((++>@C:@3(3:3:(:(44((4>@3(44(2((99((((((+2-<&0?C3
@54L
GGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTN
+
@@CFDFFFGHHGDIGIJJHIIHECHHIIJJIJIJIJJGIIJIIIIJGGIJIIIJIIIIHIIIGIIJAFHIIJBGEBEBECEEDD?BDDCDCDDDDCDDCC#
@54M
CTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACCGTACTAAGGGACTTATGTGCTTCN
+
?@8DDDBBHFHDDH@?FC?A?IEEH:CHBAA<CEB?2CCGAHFD@C99:9?F??DFHHIIGA@9DB@FCFCB@@DF=;6@;=CHHDE?5>>A@C>@>>5>#
@54N
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGN
+
@B@FDDFFHHHHHJJHJJJJJIJJJJJIJJIGHIGIJIJJJJJJIJJJIJJJJJJIJHHHFHHFFFFFEFEEEDEDDDDDDDDDDDDDDD>CDDDDDDDD#
@54O
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFDFHHHHHJJJJIJJJJGIIIIGIJJIGJJJ@GHHHJJIJJIJGJJJJJIGHHHHHFFFFDCDBBCCCDDDCCDDDDDDDDDDEEEEDDDDDD
@54P
GGTCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCN
+
@@:==DDDFF?AFGIIFIIIFFIIIIFIIIFFIFBGEFIIE?FEEIGFFIIIIIIFIIGIIIGI>EFEF9<B>AACCB;@B>ABBB?<BBBBB@<@BBB>#
@54Q
GTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTN
+
CCCFFFFFHHHGHIIJJJJJJJIGHJJIJJJJJJJJGIIJJJIJJJHIJIIIIJJJJHIIJJIIJIGHHHFFFFFEEFEECDCDDBDDDDCDDDCDDDDC#
@54R
CCTGCTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTT
+
CCCFFFFFHHHHHJJJJJJJJJJJCHIJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJHHHHFHFFFFFFEEE
@54S
GGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
BC@DFFFFHHHHHJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJHHHHHHHFFFFFEEDDDDDDDDDDDDDACCDDEDDDD
@54T
GGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTN
+
@C@FFFFFHHHHFIJJJJIJJJJJJJJJIJJJJJJJJJJIJJJJJJJJGIJJJIJJJJIJJJJIJJIJJHHFFFDCDDDDDDDDDDDDDDDDDDDDDDED#
@54U
ATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTN
+
=?1ABDDDFHDDHGGGEHHEBHEGGGHH@HHCHGGIIGBFEBHDIIGGIBFFIFEGHIIG>>DA8C@DEGG7?C>A6??AEAA@CBCBBB??@BBACCCC#
@54V
AGTCAAAGGTCAGTGGGATTGTAACAACCAGAAATATTCCAACTATAATAGTAAGTATGAAACTTGTTTCTGGTATCCAAAAATCATCTTTCGGTGGAGCN
+
?@14=ABDHDFDDCDGD@DHGCAFIICHIHBGHIIGHIGCHG;B>D<BFCAFHGCDFAGGGIGGIIIEDCHGGCGGIIIGCE=ABBDBDCEC?9??;A??#
@54W
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
@@?DDFFFGHHGHJJI?FGIJJJGIJIJJJJJJIIIIJJJJJJJJIJJJIJJIGGJFIJJJJIJJHHHFFFFFFEECEEEDDDEFEDDDDDCDEEEDDDD#
@54X
TTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGG
+
@@@F=@DDHDHFFFC>DFHGBB<FD?8@2=>=CGD>GGGGG8B><AEECCCCCCC<CACCCC@C@>C>AC:@C>>>@>>CCCDCCC:A19<ABCCA<CC
@54Y
CACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCN
+
@<@AD3BD<;FFA;+AEF<FH<FHAFE<3BGI>GIF@FFDC3(.8=F9FE;=;CEE:C<=/;;>3>>AAAABBBBB@@?;ABABB?BBBBBA??@?B((:#
@54Z
GAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCCAAGTTGAGCTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGN
+
@@+BDEFFHHHHHJGIJJJIJJJIJIJJJJIJJJJIIIIJJJJJJJIJJJJIIJIIHGIHH=ACEDCDDDDCCDDDDDDDDDDDDDDDDDDDDDDDDCDB#
@550
GTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTA
+
BB@FFFFFHHHHHIJIJJJJJJJJJJJJJHHIJJIIJIIIIJIIJJJIJJJJJIIIIJJEHIIJIEFFDEDEEECBDDDDDDDBDDCDDDC9ACCCDBD
@551
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@?FDDDDFHHHHJJJIIIIIGGIIJHIHGCFFGGIGIGHDGIIIGIIGGGFFHAHEIJFGC=A=DHEEHFHFFFF;>CA>@>B=C@D@CCDDDD08@
@552
TGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATN
+
BBCFFFFFHHHHHJJJIJJJJIJJJJJJJJJJJJJJJJJIIIJJJJJJJJIJJJJJJJJJJJJJJJJJJIJHHHAEFFFFFDDDDDDDDDDDDDDDDDDE#
@553
CGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTAGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCN
+
@@7DDDFFDDHHHJJIJGHEFGGBEFHIJIHGIIJJEHIIJIJIIJJJJIJGGGEDDDDBDDDDCDDDDDDDD9B@BDDDD@CDDBCDDDDDDDDDCDDC#
@554
TAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATGTTGAACAGATTCCTCCATCATCATAATGGN
+
B@@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIIIJJJJJHGIIJJJJJJJJJIJJJJJJIJJJHHHHHHFFFFFFEEEEEEDDDDDDDD#
@555
TTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJIJJJJIIIJJIJJJJJJJJHHHHFHFFFFFFEEEEEEEEFDE#
@556
GGGCTGTCCATCCACAAGGATCATTGCATCTGGCCCATGGGCCCTGAGGAACTTATTCAGGTCTCCATGCTTCATGTATTCAAAGACCATGATGAGGGGGN
+
C@7FFFFFHHHGHJJJJJGGIJIIJIIJJJIGHHIJIIHCHGIJJJFJJJDIIIIIJGHJHCEHHEGIJHHGGEFFBDEFEFFECEEEDDCDDDEDDDDB#
@557
AGCATCTTCACGGCCACCGTGGTGTACCCTGCTCTGCCTTTCAGATTGAAGGCCGTTGCCTTGACCACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCN
+
8?;D:BDDEE<?)@EA1E<+<E1:CD?BDE9:??DE39??BD48*?*/)8B)=='''-:A3A;.;@@?6@AA;(6>>AA(,2;??((5>3>A:A(+4483#
@558
TTACATTTCATTACACTGTGATTGATCAATATTCAAATCATGGTGTGCTGAAACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGN
+
:?;+42BD,22A:2222CFE??<3ACF4:3:<FEII><EE><**111?<DD*0?00*009BBDD**/)88=C3;-@.5@;).7?CDDA?:,:>55>(5>A#
@559
CACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCN
+
CCCFFFFFHHAFHIJIJJJJJJIGGIJIEHBEFFFEEEEEEDEDAABDDCDDDDDDDDDDDACDCDDDDDDDDDDDDBCDD@BDDDDDDDDCCDDCCCCD#
@55A
GTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJFHHIJJJJJJJJJJJJJJJJJJJJJJJHHHHHH?.6;@BEEEDEDDDDEDDEDDDDDDDDD#
@55B
ACTCGCTTCAGCAATGCAATGATATGTGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCN
+
CCCFFFFFHHHHGJIIIIJJJIJJJJIJJJJJJJJJJJDHIIJJJIIJJJIIJIIIJFFHIIIJIJJJIIIGIHFHHFHFFFDFFFEEEFDEEDDDDDDD#
@55C
CCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGCGGGATGCTCTCTGGCTGCCCTTACCTCCTGAGGCATGGN
+
?8?DBABBDDDDDAEI@:<:<33:2<?9AE<?E9E18:@?DDD?D49BBB*0==A;A'=;C':98202<:AAAA:4:><>8<4<>AA>A<<A39<?<A<8#
@55D
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
CCCFFDEFHHHHHJJIJJJJIJJJIJJHGJJJJJJGHIJJJJJJJJJIJJJJJIJJJJJIJJJIJ@FHAEHHAEHHFFFFFFFEEE>CDDDDDDDDDD<B#
@55E
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGN
+
@<@DDDDDB>DFAEEHFAGAGDBFAHGIICBFG>GA=FGBDDCHG?DE<BB@EHIAGFHE?E:=A@@DCBCCBAAACCCB?=<=C:>CCCACDDD>CCCC#
@55F
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
B@@DFDFFDFHHHJIJJJCGHIIJJJJJJGIJGJJJJIIGGIJJJIJIJJJJJHHHHHHFFFFFEEEEEEDDDDDDDDCDDCDDCDDCDCDDDBDDDDC
@55G
CCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCN
+
CCCFFFFFHHHHHJJJJIHIJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIBHIJGIHHHFFFEEEDEEDDDDDDDDCDEEDDDDDCDEEDDC#
@55H
CTCCGGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGN
+
@@@FFFFFHGHFHHIJJHHHIIJJJJIIIJJJHDDFHGFGIIEHIJIGIJJGEGFGIJHFHDFDCDD?BDD?B@BDDBDDDDDEEEDDDDCDDDDDDBDD#
@55I
CTCCCTTTCTATAGTAGCTCGCCCTGTAGATGTCTCGTGCCATCCCGAAGTCTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTN
+
?;=D+=:?DB4<DEA<2C:AF<@F?8*111::*111:100:00098??7A788./))=7.7=3.=;?C>?;A>776=;5555;9:55,:AAA38<?883>#
@55J
CAGGGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTN
+
CCCFFFFFHHHHHJJJJIIJJJJJJJJJJJJJJIIIJJJIJJIJJJJJJJJJJJJJHIIJIIJIJIJJJJHHHHHHFFFFFFFEDEEECEEEEEEEDDDD#
@55K
TTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTN
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJHHHHHHFFFFFFEDEEEDDD#
@55L
TGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCC
+
@@<7BDDDDHHHBEGIIIIEDHIIIFHIGIIGIIIIIABHHIIIIGIDHHEEHFFBDCECCCBBBCCCCCCBCCCCECC:@CACCDDDDC@?BBBCBBB
@55M
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
@?@D=DBDFACD:B::2CCEC<;::3@+2AFFFFF1:D?FFAFAFG@?:B0099?@>@?*8BFFI)5'5.)=C@>CBD>;@>736(6;=;?;?=<28<&5#
@55N
CATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGA
+
@CCFFFFFHHHHHJIJJIIJJJJJJJJIIIIIJJJJIIJJJJIJIJJJIJIIIJJJIIJJJJJJJJIJHHHHHHHFFFFFFFEECCCCDCCDDDBD?BD
@55O
GCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTN
+
CCCFFFFDHHHHHJIIIJJJJJJJJIJJIGHHHHG@GGIJHIJGHIIGIIIGHIJIJGBFHIJIJIIGHJIJEIGFHIICGGIGFHHHEHFFDDDFFDEC#
@55P
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTN
+
CCCFFFFFHHGGHJJJJJJJJJJJJJJJJHIIJJGGIJFEIJJGHIJJIJJJJGIJJJJJJHHHHHFFFFDEEEEEDDDDCBDDD@CCDDDDDEDEDDDD#
@55Q
CCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAAC
+
CC@FFFFFHFHHFIIJJJJJJGIIIFIHJICHEHIJIIJIIJIJJJJIIIJEDEHIJIG=C@EEHJJJJHHHHCCDDFFFDDDDDDDDDDDDDD
@55R
GTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGN
+
@??DDDD?DCDFDHIE@FHAFCGHA?CFG?CCGBCDH@FHDDAFH<DH@8DDHCCG>@@C7?AE>EFF5>AEC@ACCC>A>CBB;;@CDCCCC>@CCCCC#
@55S
GGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
18=:BDDDDAA2@:2<<2A?CE<E9?*1??DD:BD)?99DDEDIIEI@BCC9)8=A;@AECD=CC>@@>=@>8>=1;;>:>>>A<885&&&)9:AAA?A
@55T
TTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGTTCCN
+
@@@DDD>DH?<C:C,:?ACF>AFI?@BFEC@DFH<FAEH9EFHGFGGEFHFF@BG?99BFCHG<FGB4B=B>BB@;8@C=C3=@;C4@.=.=?)))..7)#
@55U
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@@DFFFFGHHHHJIIJFGIGHIIIJJJJJIJJJJIJJJJJJJJJJJJJIIJJJJJJJJJJIJJJJJJHHHFDDDDDDDDDDC@CDCDEEEDDDDCDDD
@55V
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@CFFFFFGDFFHIHGIJGGHIJJG@FGGHIGGIICDDHGIIGIJJJIJJJGIHJHF=BFFFECCEEEDCDCBC@CCDE@CACCCDDCD?D@CBCCDA
@55W
TGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGN
+
?@?DDEDDAFHHHIIIEHHEGGHIIIIGGGEHIIICHH@FGGCHIGGIIGAFHICCGEAA>E?;?@>C>CC;@CCCC;CC@BB<AADCDC>A9CCDD>A@#
@55X
GGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCN
+
@@@DDDDAHDFHHIIIEH<F6A<AEHEFEEE@CCC;>(6>(;A>CCDDDC>C?99ACCCCCCB05;>@3:?<@4<?A:>>A@<8<CCCCCCCA:@@CCCC#
@55Y
GTGAGATCTGCCAGGCAAATGAGATGAGGTCGCCCATGGTGAGGGCCCGCTCATCCGGGTGGTCCAGGGAGCTGGAGTTGCGGCTGCCTCCACTGCCC
+
?::ADD?>F4B?:A;FE;?F@FB<@FC39C;))88@9:*094DG16B@6F/;;7==599>@6,5;>:388,289?@?43:@0<5&)283:<394(+9<
@55Z
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@@@FDDFDHFHFGIEFHIGDGIEIHIIHIIIEHGGIGGFDGHIIIIGGDGGGIGCFGHGIJJI/=AB9ACEEEC@CBBB?BBB?@CCC?BCCACCCCACC#
@560
GGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTN
+
@C@FFDFFGH?DFECDFGJIJJGIJJDDBBC>AC@<@CC>@DDDDDD@@ACDDB8?BD?CCDEDDDCDDA>CDCDDDDDDB<B@DAC@ACDAC:@CBCD@#
@561
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
CCCFFFFFHHHHHJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJH=DDADDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDC#
@562
GGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTTATATGGAGCAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTAC
+
CCCFFDFFHHHGHJJIJJJJJJJJIIGIIJJJIFHGHJIHIJJJJIJJJJJJIIIJIJJIJJIJJHIIIIJJIHHGFFFFEDEEDDDDDDDDDDDD>CD
@563
TTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGN
+
@@@DD?DBD<DBHDBGAHA@C<HEGEHGGFB::BFB;DB9B1DBGI>C@FDH=CH@@GH>DECA==?;??CCB;;;@ACCCCC;5:?CC>CC>AACC@@>#
@564
CGTAGAACACAAGTCACCTAACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTN
+
@@@FFBEFHHBHHHGIIGIIGHJIIIIGIJIJJDGGGIDHEBHIJJIJJIGIGI@FHCHIJHHEHHF>DBDEDDDBBDCCCDCBDDDDDCDDDDDDDCCD#
@565
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
CCCFFFFFHHHHHJJJJJJIJJJJJFHIIHHIJJJJHIJJJJIJIFIIJJJJHHHHHHFFFFFEEEEEEDDDDDDDEDDDDDDDCCDDDEDDDDDDDDDD#
@566
TGTCATGACAACATGTTGAACAGATTCCTCCATCATCATAATGGCTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTG
+
?@=DDDBEHHGHHIGDFGIJIGJJJJGGIJJIJJIGGHEHGGGHGIIII@EHFGGGIGGHAGICDHAF=8C@A=EH;=CECCHEBBE?CCCCCEC>@AC
@567
AGGTCTTGCCAGCAAAGCAGTAGTTGGGGTTGTAGTCGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGN
+
@CCDFBEDHFHFHIJJIJJIEHHEFHIGIHIIIHHIJFIHHJJJJJIJHHJGGJ;?EEFDCBBCDBCCDDDCDDACDEDDDCDDDBDDDDDDDCCDCDDD#
@568
CGGCACTCGGCCAGGAAGACCTTTCCAAAGGCTCCCTCACCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGCTGCACATCTGCTATTCTCCN
+
C@@FFFDDDHHHGGGIJIJIIGJJJJIJI@CG<GHHGHIJJJJIFIICGGHIJJI;E@HBADBDDFFCEEEEDDDDE@B;@ACCCDDCDCDDDDEDE>CC#
@569
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGAAGGATGGAGGTGCAGTGACTGGCTGCN
+
@?@DADDAF:CFDGFEBAG:<C??CCAFHIEHIIEBEB?DGDCFF:G@G@??F?DFBFCA;F@FA7@EE3AEB'6;;@AA=>;B5<AA>:>:::>BB???#
@56A
CTAAGAGTTTAACCTGCCGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGN
+
@CCFDDBBFFHHDEGGJIIIIJIJHHIIGIIJIGDGIGIGG>?BBGBEHIIJCGIGH8BGAHCHHIGIIJIHEBCHHFEFFCBC@CED@;CCCCCCCCCD#
@56B
CTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTG
+
@@<DBDDDDHHDDEHGIBGHGIEIFGHGIDGGEFHIIGIIGGCEHIJBHIJJIGFFHGGIGGCHGHGEHFDEDBAECEE;A
@56C
TTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTN
+
@C@DFFFFHGHGHIBFGGAD@FHIIIIHIIIIIEHEIGIIIIIGDGGGIIIIHICHIGDHICCGHIIHIEIGGHGIHGEHCEEFEHFABCEFDDFEECCC#
@56D
CTTCTGTCCATAGCTGCTCGGTTGCCCATAGGAGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
=;++4ADD?FBB?EBFACFE@A@FDF??CFAA*::??DDEEFFIBFBDDBFFAD@FGCBF=;FGDFCD7=A<E?<BAB>:6>@??>@A:35<9:@@:5<9#
@56E
GGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATN
+
?@1ADDDDHHHHHIEDEGHIGIGIICFHGIIEHEGEHGDAGGGFAHHFGEHD=FGDEGGGGGIDEEAEFFFFAACC@;ABCACCCC@CBB?BA?:A>>@C#
@56F
TTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGGGTAATGCACTCAATGACCTCN
+
1?8DDDDD>AAFD3A:<E=FEA?D?G>FF491??B?*?;DGFC?FA0@;'-=3@EAEB<>BBB;'5?>981259@35A+318:A:43:3439?(+:4(:3#
@56G
CTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGTGAGGAGGCTCTCGCACAGCTCCGCCCGCTCCAGCGACTCTACGCTGAACATCTTCCCCGCCN
+
CCCFFFFFHFFHHJJIJIJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJEIJJJHHDFCDDDDDDDDDDDDDDDDDDDCDDDDDEDDDBDD#
@56H
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CBCFFFFFHHHHHJJJJJJJJJJJJGIJJJJJJJIJJIJJJJIJIJJJIIJJIJJIJJJJJJJJJHIGHHHHFFFFFFFDDD>@DDDDDDEDDCCDDDDD#
@56I
CTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTN
+
@@@BDBD2=:CAFEFG>GIIE<AB@B?HC<CHHI@+<?FGGIIFI<FG9BG@9B4BG>FGIEFFEGIFI@BBCD@C@DFFC@=CEA====CB@?>>;@C@#
@56J
CGTTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATN
+
BB:BDFFFHHHHHJJJJJJJJJJJIJIJJJJJJJJJIIJJJIJJJJJJJJJJJEGHJJJJIIIIJJJFDD5;@CCCDDDDDDDDDACDCBBDDDDCCDDD#
@56K
GTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGG
+
@@=DDFFFHGHHHJJJIJJJJJJJIJJJJJIIJJHIJJJIJJJJJJJJJJJJJJJJJJJJJJJJHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@56L
GGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGN
+
@@+=DDEDGFFHFIIIIEG>FEGGIAHBHIIIGIIGCHGHGIIIIFIII<GDFFHHII6@GHBEDFFCF?CCCABB<=ABCCCBA@CCCC@>CCACCCCA#
@56M
ATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGN
+
@@1BDDFFGHHGHJIJJJJJGIJJHGIJHIIJJIIJIJIHIJJC@?BBDDDCDCDCCDCD@CCC<?CADD:ADDDDDBDCCDDCDDD9@DCACC<@B@BC#
@56N
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
:@1ADDEDHHHHBHJHIIJGIJJJIHHIJJJJ:DHIGEIHHIJBCHGFHIIIHGHHHFFFFFEEEEDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDEDDC#
@56O
GCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCC
+
CCCFFFFFHGHHHJJJJJJJJJJIJJIJJJIJJJJJIHIJJJJIJJJJJJIHHHHHDFFFDDDDDDDDDDDDCCDDDDDDDDDDDDDDDDDCDDDDDDD
@56P
GGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
CCCFFFFFFHHHHJCGIJJJJJJJJJHIJDGIFHIJJJJJJJJJJJJGHIJJJJJJJJJJIJHHHHFFFEDBEEEDDDDDDDDDDDDDDDDDD@CD@CD
@56Q
GTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTN
+
C@CFFFFFHHHHHJIIJJJIGIJIJJJJJIIGJIJIJFIIIEHHHIJIGIJJJJJJJIGHIIIJIGHHFF7@@CCEEEEEEDDDDDDD@CBDBDDDDDDD#
@56R
GGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGN
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJHIIIJJJJJJJJJJJJJJIIJJJJIJJJIIJJJJJJHHHHHHFFD9>BDDDDDEDDDDDDDDDDDD#
@56S
TGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGN
+
CC@FFDFFHGHHHJFGHJIIIIJGIGIIIJJGJIJJJJGIIIGFEGIIIIJEIDIJIIJJIEEHHFHDECEFFFEEEEAACCDDDDDDDDBDDDDDD+9@#
@56T
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CC@FFFDDHHHHHIJIJHGIGHGIJIIIGHDHGIGIJCEGHIJJIIJJIFGIJIGIGIHHGFHFFF>BB?CCDDDCDD>BDDDD@CCDCCCCDDDDDBDB#
@56U
CTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCN
+
@BCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHHIHHHHHFFFFFFEEEEEDDDDDD@@CDDED#
@56V
GGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTN
+
@C@DFFFFDDHDFHGGIEIIHIIIJJJIIJGFEEGFHIIHHJFHIIIJJIJJIIJFGEGGGBGHEAEH@EEHHECEDDEFEEECCCDDABACDCCECDBD#
@56W
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTN
+
CCCFFFFFHGHHHJJJJJJJJJIJJJJJJHJJJJIJJIGHIJJIJJIIIIJIJJJJJJJJJHHHHGFFFFDECEEDDCDDDDDBDACCDDDDDDDECCDD#
@56X
AGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCN
+
@@@BDEFFFHDFDHGGHFHGIGGDHHEIGIGIDADGGHIJGIEBFFHF@CFHCHHIJJJIGIEHEEEHFHCDEBBDACEEDCCCCBBBBDBD?AB<@ACD#
@56Y
TAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCTCATCAGGGACTTTGATGACG
+
:=?D?DBD<FF6)2A:C6:))B?DF????:B?/;@)))8==9=@/4@-(.7?;@;3>>8=:=/0()2888>530<7<((+:44A>@8(28A@>(+4>48
@56Z
TGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTN
+
@@<D?@DDHBHFFEHH<GEHIFFHGB?FEHGIBGEHHIIGHCGDAAGHGII@BBFCGHIFGI@EGAGHEHFFEEDCEED;@AC;@>CBBBBBCCCACACC#
@570
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGN
+
B@@DDDDDHHHHHIIIIJFGIJIIHIJIIIIGIJIJJIIJJJJDFHGIIGHIIFHFGGIJJJAH@EGEGEAEEEFEFFDDEDBDDBDDDDDACDCCDDCB#
@571
CTTTACTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTN
+
1=+=+2ABDDD<DE@?4,A+AEFC>AFFEEE9E+CEFB?EDEADEDD)??9B??DDDCEEEEDB<=8)/)==CDE:CCEII@@CE9=7=(,;?(66>AAA#
@572
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
@@<DFFFEHGHHHJJJJJJJJJJJJJJJJJJJJIJJIIGIHGIJGHJJJJJJJFHIJIHJJ5CHFEHHHFFF?BCEEEDCDDDDDDDDDDDDDD9BDDCD#
@573
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
BC8DDDFFHHHHHJJJJGIJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJIJJJJJIJHHHHHFFF=@DBCDDDDDDDDDDDDDDDDDDDDDDDDD@DDD#
@574
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTN
+
@?7DDEEDDDDFFHIIG<@GHIIIIH@EBGHHAGCGHHHGCHIHIIDHIIGEFHHI;=@EEH:@@EGHGDHEEEDFC@C>CCCC35;??ABB?A;<<BB9#
@575
CTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
@@@DBDFFFDHHHFHEHIIGIJIIHHG?CGHGFHIGDFHIIBGIJDHHIHIEFGHIIIEGHFCHGFFFFAA@C@CCCBDDDBB:@CDC>CCD:3>CBCD
@576
TGCTGCTGGACATGACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAAAATGG
+
@@@DFDE>F;FBDEHGIEHEGGGHIGIDCGHBEH@EHHFFFDD?A@ACCCDDDBDCDDACDDD@CCDDCCDDDCDCCCDDDCCDCAC@@DBB8AC<A@C
@577
CTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGN
+
B@1ADDFFHHHHHIJJJIJJJJJJJJJJJJJHIJJJJJJJJJJJJJJIJJJJJJJJJIJJJJJJHHHFFFFDEEEEDDDDDDDDDDDDDDDEDDDDDDDD#
@578
CAGGACTGTACATTTTCTGCCCTGTTGGGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTN
+
=;1=4==B=A?:C<F??E:EFAEE<CF+8810?G9CFD<:?B??9?9B?BBAF9D<BA:BFECC@===C=77@C==E>EC>=BBDDB>C@>(6@A@@;;;#
@579
CTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGG
+
C@CFFFFFFFHHHJIHGIIIJIIGIDFGEIIIIGGFFHIGJJJCFHIJJJJIJJJIHED?BBBDDDDDDDDCDDDEDDDD5>BCCCCACEDDECCCDCD
@57A
AACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGT
+
@@@DBBDDAAHHHFGE>FAEGAA?FHGIDGG?DEGCHG?@BBDEHI=BB5@GHH)7CGA=CECBDEDDACC;??CC@@BCCBC3>CCCB<<8<<CCAC>
@57B
CTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATN
+
CC?DFFDFHHHHHJJJJJJJJJJJJIIJIIJGHJJIJJJIJJJGIIJJJJJIJJJJJJJIJJIJIGEGEHHBFFFFFEEEDDDD>BBBD@CCCCBCDACC#
@57C
ATGTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTN
+
1=1=ADDDHHGHGIIGHIIIJJJJJIIJBHGHIFHHIJJJIJFHIHHBFIIGHGIHIIJJJICGGGGHHIJJJJJAAFCFFGG@GIJIIHHH@EEFC@C@#
@57D
CACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTN
+
@@;BDFFFGDDABFFHEGIFIGHEFH<AE?FHHDDHGFG<:C?FHHEGGEAG7DAGHIJB8??@FGII@EHGHGGAFH@EDECGCEFHH?EEEFDEFDCC#
@57E
CTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCN
+
?@@DDDDDHFFFHGAFHIG@GCFHGIIECHHHDECCBBCCC(<CBCC>AC>;@C?<ACDCD:@CACC??AA@A>CCB>B5:@>A8<?CB<>ACCBBCBCC#
@57F
CAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCN
+
=??D?;D?=CDD<E4+2:CF4CA+3C?AFCF<CEDBDEEC??DEB*??BDDDD9?BD?DB<DD=3=B:@CE=ACE;=@@..?ADD=C>3;AD3@A6;;;?#
@57G
GTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCAT
+
BB<DFFFFHGHHHJJJJGIIJGIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJHHHHHHFFFFFFEDEEEDDDDDDDDDDDDDDDDDDD@CCCDEDDD
@57H
CCCGGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATT
+
CCCFFDDDDHHHHIJIGGCCHEGIGGGIJJIJJIJIJIJIJDGIIGIIIJGIGIJJJJGGDGGIJJGJJGHIIHGGGFCDBDBBDBDDDD3>CCCDDC
@57I
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
@C@FFFFDHHGGFHEGEHIIIEFGIIIIJIJJEHHHJIHIIIJFGH?FFGG@BBFGIJJJGGHGGGGGHIAEEEB@@@;>>CDBDDCDDDDC5::?@?>D#
@57J
GGTGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAAC
+
?<1=BDFFHHHBFGEFGB<FEFHIIGIGBH@BDBCGGCGCHFFDG@@*88BBFHHEGIEHHICGEHFEBB9?=C@@>AAACCDCCDEEDC@A
@57K
CATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGAATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTA
+
11444+223<8<AFHIGGGHCGHIEEGF<;9?D>D>>B??<DEG:*?BG>DBC??@??BBFEFCF>CG@CH@H)75?AADDB;>6>A;A;;?CCCCCAD
@57L
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
CCCFFFFFHGHHHJJJJIJIJJJIJIJJIJHIIJJJJJIJJJIIJIIIJIJJJIJJIJJJGGGGIJFHGGBDEFFFEE@CACDDDDD3=@B@DDDDCDDD#
@57M
GTGAAAAAGTGCCTTGAATGTAATTTGCGCAGAGCGCAGGCCTACCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAA
+
B@BFFFFFHFHHHJJJGHIIHIJJJJJJIJJJIJIIIJJJJJJJIJJJJJHHJJIJJGGHHHHHFFFFFFACEEEDDDDDDDDCDDDDCDD?BDDDDBD
@57N
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGGAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
?;+=:B32?BD?FBDHIFIICGH>DDF??EEEB<F<DF*?9?FCDGBFE>@GI1=CA(;@E()5?.7;B9@1,;;AC-;5;5:59<B7:,:?<?9@B<:@#
@57O
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATN
+
CCCFFFFFHFHHHJJJJJIHGGIGJIHIGIJIHIJIIJJIIGC8CGHGG@GIHGIJJEGHHHCB?BDFBCACECC@CCD>ACABC?ACDADDDC@>CDEE#
@57P
TGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACTTGGCACTTTTGAGCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCN
+
@@CFDFDFBFDBFFHIIGIIEHEBGIIHH@@DHGCGBDHDHGCGDFHGHHHGBGGDHHIIIDFFCHCAH>CHHEFFF@@@ACECE@?;=CCDACC>:ABD#
@57Q
TGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
@@@DBDDACFAHFIIGGG??ACBEBFHGEHIIDDGGEHDCEEIIIBGICDHDHGBCBBBGAHI??ACHHEEEEBCCCC@CCB@ABB5??B>CCBCAB8AA#
@57R
GGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTN
+
@7@DD=B;FFFFH@ACGB:CE>FCBF8@61?CCC>?8>A3@BCD>CAB9CCB@BBBB<?CCACCCCCC9>A>CC@CCCABBB9>CACBACA:A::98@C:#
@57S
CTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTA
+
??;?DA?:AABD?EEBEEB,AF<EF,3++2A<C*:?C??4:4CDDDE*B???9?*9BA38B:DE@4)8BB>CC@C4AC))=AC?C3?)7));;377;@
@57T
TTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGC
+
@CCFFFFFHGHHFFGIIJJJJJJIIIJHGGHDHGI@DHIFIJBFHIJJJJGIIGIIHCAA8@EHIJHFHFDHFFFCEDEEECDDCC@ABDCCDCBC??
@57U
CCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCN
+
@@@BADDFHGGHHIIIGGHEE>@FFHGCEHGIIIDG;DGGGDFHIIIIIIIIGGBFHIB>CGHE=C;EGEAEFHHHDCDFFFEA.6@A>A>>C@C;ACA>#
@57V
GCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCN
+
@@@BADD>F:<DFH@FGIH?F??HCGGGA8?EDGEBCFGDDGG@FBFHGDHHDGGEHGFCIGEACF;@)=CAGEEFCHEEE);;;.;@=?=9==@CCC@C#
@57W
GAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCN
+
@CCFFFADHHHFDGGIJJIGHIHGGGGEHIJJJFIGHGIIJJIJJIGCHHJJGIIGGIIJGHBECEBEDDDEDCCBDDDDDCDDDDEDDDDDDDDCCDCA#
@57X
CTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTN
+
BCCFFFFFHHHHHGJIJJJJJJJJJJJJJJIJJJJHIJJJJIJJJJJJJJIIJHHIHIJJJJHFFFFFEEEEDDDDDDDDDDDDDDDDBDDDDD@CBBDD#
@57Y
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATN
+
BBBFFFFFHHHHHJJJJJJIIJIJGJGGJJIIJJIJJJJJJJJHIDEIJGIJIHIIGIGHEHHFEFFFEEEEDDEDDDDCDDDBDDDDDDEDDD@CDDEE#
@57Z
TTTTTAAGCGGCCGCTTAACTATCAAACGTGTCCATTAATTTTGCCGCTGAGGGTGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGG
+
=?+A;DDA+@D@@?)??8?9?9DDED*9@D;D8?9?BEEIIIA>==5/'-==?=??6@A;(6>>(;;>;;>:>>(,,>A3>(+4>A>B>>+:>>ADAAA
@580
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
CC@FDFBDDDH?FGGIGIGGHIGGGIIIEGIEGGGIEHIGG@CF:BFGGHHHIFFG?BD>CDHE>G>FFFGGEHG@EEEHFEHDFF@C@BBCECEEDDD
@581
TATTAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCAGGTCTCGGTN
+
?@+AA?BDDDFHHJIIIIIJJEIGIGEEGEIDDFHIJIGDGIHHGEEIHJJIJJJ>FHHH74C;A=EH>;@BBDDDDB=ACC3:A@?@DDDDDCCAA9<?#
@582
CCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTCTCAACGTCCGTCTCCCTN
+
CCCFFFFFHHHHDGIIJGIJJJJIIJJJJIIIJJJJJGGIGIJJJJJIJIIIHIIJJFFHGHHFDDFFFEEEDEEDDBBDDDCCDCDCDBDDD@ABDDDC#
@583
CTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTA
+
???D1A?+:DDBDEE@9B<FDDFECCEIEEC>*31CED4?D9C<9BBECBBDDD9BBEI8B@<=CAC>@>3==--.=@@:).?AAAADEE@A;;-;>A>
@584
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
BCCFDFFFHHHHHJJIJJJJJJJJIJJJJJJIJJIIIIGHJJJJJJIGIIJJJIIJIJJIJHHH9ACBDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@585
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
CC@FFFFFHHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJJJJJJJIJJIJHHHFFFFFFEEEEEDDD?BBDDCDDDCCDDDCDD#
@586
CAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGN
+
@@@DDFBAHAAFFIGGBHIIGHHIIIECHIIFG;BDGIGHHF?<B>>A;@=5>>@CCCDC>@CDCCCCDDDD>8@C?BBCD>ACDCDDCDEDCCDD:4:A#
@587
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
<<@DDADDFF<?++A<CF:C8CFFA9<?DE<BBAA;GFE@?FD8BDAFF9@FFACCF@EEACEDDD?;:;A@A::5<8>+<ABAB::@>@@@A<?B>9(2#
@588
CACGTAGCCTTCGTTGGAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGGGAGAAAGAGGCACTGTGGCCTCCTCTN
+
==8B:AD=?:A:CE;B+AC78C?C:)0?A4;ED93?(((,,3'66(99',,9,>A3(+((++++(+(+4(((+(+2&&(+4>@?82((3>B(21:+8(+(#
@589
GCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGA
+
@@@DFFDFHHGGHJIIJJIGGGHIGJJIHGIIGIIJJJGIJGIBDFBFGGIJIIJJJJJJJEHEGGIIJGHHGHFHFDDDFF?@CDEEDEEDDEFDDDD
@58A
CCCCATACAATTTGATGACATGTGGTGGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGAGGCGTTCTCTTTC
+
???DD82:CD4??C9B4AFC,3<C<3+28:1:DDDD;DBBCB9D9?D7B;(.B=AC>=@=;AAC=.==7;;9>@9;;>;A?<:?5>??>0528>AAA4
@58B
CTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACN
+
:?+=ADDDHHHFHJIIJGIJIGAEGIHGEHGGIJJJJJJJJIIGIJIGIJFGHIHBEBECEEEDCDADDDDDDDDDCD=BDDDDDDDDDBCCACEDD>CC#
@58C
GTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGN
+
??1ABDDDFHBHHFHICFDFGIEGIGGIJJIEGIIIIIJJIIHHFE@CBDAECACABDBDDDDCDCDCCCCCDDACB9<B?CCCDDD@CCCCCCACBDCC#
@58D
ATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTN
+
?@:DDDDFFGHHHGIGGGIIIJGHJCGHIIJIGHIIIJJHFHIDHHGIJIJI9DFGIIJIIICHH@DGGIJGHIEHAGHHHFEFEF@DFCEEEEECCCCE#
@58E
GTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTACACACAGGTCTACAAGGTCAACCAAGGTGAGTAAAGGACCATAAAACGTTN
+
@@@FFDEFHGFDBGGGIIGHGGIJFIJGEHGIIJGGHHIJGGJJJJIEHIIGHIIGIICGIJJJJIICHGHJGHHHF;@DE>CEECE@BBBCDDDDDDBD#
@58F
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJEHIGHGGIJIIIJFHEHIGHIIJFEGIIFEBHGFIJJIGEIJJJJFGEEHCEHFFFEEAA;@@CCCDCDC@CCBDCCCACCCCC
@58G
CGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACN
+
BBBDFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJHHHHFFFFEEEEEEDDDDDDDDDDDDDDDDDED#
@58H
CCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTN
+
CCCFFFFFHHHHFGIJJJEGJFCFFIIJJJFJJJJIIJJJJJIJIJDFHHIDGHHHHHHHFFFDFEEEEDEDDDDCDDDDDCDDDDDDDDDDCDDEDDDD#
@58I
CTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATN
+
@@<DDDDDFGHGHGIIIIJGIJHIFGIIE@FHDHIHEIIJHGIGIIDDGIJIIIHHIGGJIIJIIGIGIIICGIIEGGGHHEEHEACHHHGFFFDFDBCD#
@58J
CTACGCTCAAAGGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGACN
+
CCCDDFDDHHHHHGHIJJJIHIIGHIJJJIJJJJJIJBGIIGIIJJDGGEGGIJJJJJIIGDFHIJJII?AHFD>AB@DCDCDDBDDDDDDDDABBDACC#
@58K
CACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCA
+
@@@FFDDDFHHGHIIJIJIIIIJHD=GIJGFHIGEGIJJJIGHJJIIGGHHGHGFFDEEBCCDDDDDDDDCCDCDDCDDBDDDDDDDDDDDDDDCCBDD
@58L
GCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCN
+
?@<ADDDDHDFD?AGEG@?:FBHBDHGII?GGBDBGHGHGEGEFC:??;B@@FGDHCFHGGGIGIIIGIIIIIEEHBHH>BDE;B>@>;?,92;:>C@CC#
@58M
TGAGAGAATGCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGACCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCC
+
@@@DDDDDD??DDADHGGGE?<A:FEEFGGIIIGHBHBGEAFGHACHEAA=A?BCD;@AC;?>?CBCC5@>A?CCCCCCBB@BCACCACC:@?CC:CA
@58N
GTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTC
+
@@@FDDFFHGHHHGGIGEEHHHIIHIIIGAGGHIIIJIIJGJJJIGHIGHHIGIIHJJIHIGIICDHIIGJJIIIJIGEEHFGDFFFFCEEEEDDDBDD
@58O
CGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGN
+
?@7DD@@ADFDDFHHGEB?FECE::8?FGGF?:6DGEI9B@CAGGHF4@@6C5@ABC?BBCBACCCCB?>>@B95><ACCACAC@CCCDCCCBCA:?CCC#
@58P
GGGGTCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGN
+
B@<DDDFFHHHHHIIJJIIJJJJIJJJJJJJJFHIHJJIIJJJJJJJJJJJJJJGJIJJJJJIHHHHHGFFFFFFEEEEEEDDFEEEDDCDDDDDDDDEE#
@58Q
CTCAAAAGTGCCAAGTCCAATAATCTGCAGCGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCC
+
???BDD?BDDDD?+<2<C<FFDCCFEI>FE+111C8:100B:?D<DE9B?D8D<91B;8A))/;(5;:'=9@9A3(>;185:::(,,,5>A>A:AA708
@58R
GGGAAATTCCATTCTGTTCCACATCAGCTTATGCATTGGAAATTTTGTATCTTTAAAAAAAGATTTGAGGAACAGAACTGTGTTTTGATGTTAACAAATTN
+
CCCFFDDEHHHHGJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIIJJJJJJJJJJJJJJIJJGIJJHHHHHFFFFFCEEEEDDDDDFDEEDDDDDD#
@58S
GGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATN
+
=??D=BDDDD<6CFEC<C><FFHHH@FHHBDCAGHGGHGGIICFGHC@B?99?<@FCBCCH;=AHFFCCBBBB>>5>:>99ACCCCAC:@@CCACCCC:B#
@58T
ACTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGN
+
:?:BBADD>CAAF><AE9EDB@FGHIH@DHE<AB?FDFBBB>DGEGHEDAEG?FBBBGGEHG>CFGIEG=FDG<F@CEI;CHH@AEEC77@D9@CCCEEC#
@58U
CATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGGAGGATGGN
+
@@@FADFFGDDA?FGIIBH@EEHI9CCCGDCHGICHIIGCGCBGHEGGGCGBHCFICGDFFFAGA;=6?BD:@BBEAEA>(55;55;?AA==&09>BA@@#
@58V
CTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJIIJJJIJJJJIJJJJJJJJJJJJJJJEHHHHFFFFFFEDEDDDDEDEFDDDDDDDDDDED#
@58W
GGCAACACATTGCCTTCCCTGAGTGAGATGTTAGAGGGGATCTAGCCCAGGTCTTAATGATAGTGGAAGACAAGGAGGAAAGAGGGAACGTTGCTGGGATN
+
???DDDD=ADFD?ACF:CFBGDGACHHDFHHIIGHII):??@BG9?;FBFI.8=B@GA@@@;CEHIACAHE=;?D??C5;(;;;??8<(;9?B<>@>@<:#
@58X
CCGTTCCAGGGCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGN
+
?<?DBA:DD>)<C?:A?C;:F@<<?CEC4?E@E@DADII;D<BBD9D89999BB8==CCCE)=;AD-;AC>CA;A@AD9>9>???5;==AA>>A;5(>,5#
@58Y
AGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGAT
+
CCCFFFFFHHHHFJJHGIIJGJJJJJFGHIJIIJJJFGHIJJJJJJJIJJIJJIJGIJIIJJJCFGIIJIIJHHFDBCDDBCDCDFDDDDDDDDDDDDD
@58Z
CCGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTN
+
CCCFFFFDHHHHHJJJJJJJJJJJJJJJJHHHHFFFFFEEEEEEDDEDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDEDDDDDDEEDEDE#
@590
CCAGTGTTAGTGCCATCAGCTCTCGTGAGTGGTACAGGACTCTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGA
+
=<?DBDDDBDHHFIGIIGGIIGIGIIICCAFG?FDEGHHG@HIIHIGIGIEE?FDHAGGH6AHGDEHHHCADF@CBE>ACE>CACC>CDD?CCC>::5
@591
CAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGN
+
;;+=4AD?<DFDFFBEEFEIEEFFH@FBEFFFICBFEEFFDEFFFIF>D>FFEDFG9*=CEFGGICEE:@EFE@==DEF2C;B@DCC9,;?5:@3::1<>#
@592
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
?;;DDDDDDDFF<CFECFHGEGHACA9CCDCCGECB4?BFHFHHDFFG-8<FCGHG9DA5.7?E?BDDEEE@A?B?CCB?BBBBC;@CB?C@CCCC@CBB#
@593
GTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTN
+
B@@FFFFFHHHHHJJJJJJJHHHHJJJJJJJIJJFHHIJJIJJJJIJJJJJIHHHHFFFDDDDDDDDDDDDDDEED@CDDDDEEEEDDBDDBDBBDDDDE#
@594
CATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGN
+
BC@DFFFFHHHHHJJJJJJIIIJJJJJJIJJJJJJJJJJJJJJIJJJJJJJJJGHIGIJJHHHHFFBDDEEEDEEEEDDDDDDDDDDDDDDDDADDDDDD#
@595
TGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTN
+
@@<DAABBHDFFFDGHAEHGI@CDH@HHGHCBG?:E?EEGDCHICHGA>@:B<BFH>>DFBFG@FGDFGFGHIIII@DFAC@=D>ECEH;=?.777;ACB#
@596
GCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCN
+
?@CFDFDFHGHHFHIGIIHJJJIGGGEFGHGIJGGGIJJJGJIIJIJIGEIGHHGGFHCFDCGGEIGIJGGHHHBEDDEEEEEEDDEDDDDDDDDDDCCD#
@597
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@?@D7DDDFDF8?A4CBFF<BFC18EFFEFFEFG>GEFFF9D9?*9B8?BC)(...=).8;=7@CE732?AB=B;@>@D:;6;>AB?'3;A(54:3(4:
@598
CCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCA
+
@?@BDBEEFFBHADHHBGIHHIHFCAHGGGGIIIDEGIICHGEHIBGHI<GI<FHGGEGHHIIIIIIIIIEHHIIIGIE>CHAHDEFCCEEC??BBCCA
@599
GTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJJJJJJHHHGHFFFFFFEEEEEEDDDD=BDD>CCD#
@59A
TTCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTN
+
BC@FFDEFHGHHHHGIJHJIJJIJJJJJFJJJIJJJJJJJIIIJJJJJIJJIIIJJJJJJJJJIIJJIJJIJJJIGIIIIGBFBCCDDCEEEDDEDDDDD#
@59B
CTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTN
+
C@@FFFFFGFHFHIFHIIIIIJIJJJIGJIFJHGJIJJJIGCGIJJJIIHGGEGHIJFHEGIJJJHGFEFFADCDDACDDDDCCC>@CDD8?ACDBDDBD#
@59C
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
CC@FFFDFHHHGFIJGGGGGGHIJJIIJHIIJDFHIGIJGIJGGEGBFHIHIHIEHHCGIGIJIJJIIIIHHHFFBCCCECEDDDDDC@CCC<@CB5?BD#
@59D
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJIJJJJJJJJJJJJJJJIGJJJJJJJJJJJJJJJJIJJIJIJIHHHHFCEFCCAEEEEDDDDDDDDDCDDDDD
@59E
CATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGN
+
=B1=DDFFGHHHHJJJJJJJJJJJJJIJHHIHIJJJIJJJJJJJJJIIHHIJJJJJJJJJJJJJIIIHHIJHHHHGHHFFFFFFEECEDDCBBDDDDDDD#
@59F
AGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTT
+
?@@BA?DDDFFBH@FHHIIIHGCDHCHFGHEHGHBFH@GFGGIIGGIHGGG@9EGGIIIIIIEGGHIIIACAGHIIG@DCE=A?E=>?7?CEBECCEDE
@59G
CTACTTGAAGGCTGCAAATTCTCTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTN
+
CC@FFFFFHHHHHJIJJJJJJJJJIJJJJJJJJJJGIJGIJJJJJJJJJJJJJIJJJJJJJJIJJJJJGHHHHFFFFFFFEEEEEEEDDDDDDDDDDDDD#
@59H
CTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTN
+
??@BDDDDFHHGHJJGHIIIIGIIIHJJHIGGGI?GHIJJGGEHHFFFFFDDDDDDDDDDDDDDDEEDDCDDDDCDDDCEDDDDDCDDCDDDDCDDDDBD#
@59I
TTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTN
+
CC<FFFFFHHHFHIJJJIJJJIGHJHIIIIJJGIJIIJJJJJIJJJGIIJIGGHGIHHIJJJIIIJIJIIGAHHFFFFC;ABDACDDCDD@BCC@ACCDD#
@59J
TCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCN
+
=@1=BDDFHHGHGJJJJJJIIJJJJJJJJIIJJJIJIJJJJJIIJJJHIIIIIJIJJJIJIJIJHHHHGEHFFFFFFFEDDEDDDDDDDDCDEDCDDDDD#
@59K
CTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCN
+
@@@DDDFDFDDFHIJJIFHHGIIJIIIIIJGCHHEGGIJIIIGGDIIEB@DFEIHBFCFBGGGGIIJJJJIJIJJAHCC37@GIIGCHEHAEHFFCBDEE#
@59L
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@@@FDDDFFBHBFEGGIGFHHIGGADHIGH9CDFEDHICCHHIBCHDFGHA>FGBBBBFHGHGAAAB3>CCCCCDCDB?B:@DD@CC@?ADDD@::AA@>#
@59M
CTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGAGGCCAGGTCTCN
+
@@@DDBDD?<CDDH;FGBAC,<CHGBHH@4A<CBHD39C?F?8?FHEH;B===C=8@@37=C;@7@EE<A<BEEA;;;5;@;;;@(:?(((,8@814(+:#
@59N
CACACCTGCCTGTCCTGAGCACATGTCAAGAGCAAATCTTTGAAGGGATGTGTGGCAAGACCCCAAAGCTCATCTGTATGACCCTGTACTTCTATTTGG
+
@@?DDDD3?CFFFFIBGDFE>FBF<CDAHGFDFFEFIIFFFFFBBDEFAB*/?FFD;FF;F>CFAEEECCC;>?BD??BAA>>CBB;>5@B@A>A@DDB
@59O
TTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTN
+
CCCFFFFEHHGGGJIIJJJIHGJJJIHGHHIGIJGIGIIGIIIGFHJJJJIJIJJJJEGGIJHEHFFFBDFFCEDCDDDDDD?CCDDDDCCCC?A>CCDD#
@59P
CATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCN
+
@C@FFDDEHDHGFGHGIGJJGHHGHJGIEHJJGGHGIIIDHIGFGGGGGIIJIIIIIEGFGGIFGEFHHFFFFFFEECEEBDB@BCD@>CC@>CC>:ACB#
@59Q
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTN
+
@@@1?BBD8FF?FFEF@4FFADFFFECEFE3?ECG3*CBFF9BB<DF>?F<6AAAEI(=7?)=CF87;;>@B@B?6;8>:>>B;@B<<@B@B:49?>3@(#
@59R
CCTTGGGTAATGCACTCAATGACCTCCGTGTTTGAGAGTTGGAACCATGGCTGCTTTCCATAGGTGAAGATCTCCCAGAGGATCACCCCGAAGCTCCAT
+
?@@DD;:ACDA?<CCBEHHHEEHH>FEEA:EFGA?FGGDGBFG<DFDH@GH;;FHBGD@F7=;7C@DE;CAEHEEECCD;;6@CBCCBB?@BBBCCA>:
@59S
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJIIIHHHHGFFFFFFFDDD;BDDBDDDEDDCDDDDDD#
@59T
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFDFFHHHFGIIJJGHIIJJIJJJJJIJJJIJJJIJFIIJJJJIJJJJJIJIJJJHHHHHFFF9@BBCCCDCDDDBDDDDDDDDDDDCDDDDDDDB@#
@59U
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGN
+
CC@FFFFFHHHHHJJJJJIJJJJJJIJJJJJJJJJJJJJJJIJJJIJIJJIIJIJHHIJJJJIJJJIJIIIJHHHHHHFFFDDDBDCDDDDDDDDDDDDD#
@59V
CCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJIJJJJJIJJJJJJJHHHFHFFFFFFEEEEEE
@59W
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@:DDFDEFHGGFJJJJFGIFHIIIIIJIJIIJIJIJJJFJIIJJIIJJJGJJJJJJIJJJHFGIIIJGGHFDDDDDDDDDCD@CCEEDDDDDCDCCDD
@59X
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
@@@DFDDFFBA:D@GHEFEFHB@GBFFGA<@DG0?DG<FGIFHI7CGIIBFHEGIIG7;AAEHHFB9<?CCCABC:@>C>@ACBBB?-<ACC@>C>ADDC#
@59Y
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTN
+
@@<DDDBDHHHFFIIHGHIIIIIIIIIIEFHIIIIIIIIIIIIGFHIGIIIIIIIEGCCHIGGGGCHDHHFEEDEEECCCCCCCACB?BCBBBCBB9@BB#
@59Z
AGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCN
+
+=?DBBDDFFDFCDFGHG<BEEBHCABHHGIIGICEHE>4D9DFDHGDH?@@GHHG>AEC=CE3?9@D>@AC@ADDEEFC@CCC>;:>A>A88<0524::#
@5A0
CGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAG
+
@@+ADDFFHHFFHIGHGGIGEGGFGGIJJJGGIJJIGJGHIGAFHGGHEGHIJJJGIIIJFGIEHHIJICEEHHFFCDEDDDDDDA>CCBCDCCDDDD
@5A1
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHGHGHIIGFHHIHIGHGFHIJJHGHIHEGHIIHHIIIJJJJICHHGGIJIIIJDGGHGIAHEHHFFFD@>CD>CBB55<@CDDDDBD@<A
@5A2
GTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCN
+
@??DDDDDHDDDFGICEGIIGBHIEII6DFFGHGHIIIGEGIGIIIIFGHHFFFBCEEDCCD?>@@CDD5@CAC>BCCCCD<?B?CDDDD@CCDACCDDD#
@5A3
CTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAAAAAGTGTN
+
BC@DFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIIIJJJJJHJJIJJJJJJJJIIJJJJJJJJJJIJJJJFDEEEEEDDDDDDDDDDCCE#
@5A4
ACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGN
+
@CBFFFFBFHHHHJJJJJJJIJJJJJIJJJJIJIJJJIJFHJJJIJJJJJJJJJHHHHHHFFEFFFFEEEEEDDDDDDDBDDDDDDDDDDDECDDD0<BD#
@5A5
CTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGN
+
CC@FFFFFHHHHHJJGGGIJJJIJIJIIJIJJGIIIFHGIIIJJJJJJGGEHHHIJFHIIGGHIJGIGIH@GHIGIHCHFFDDDDDBDCDD@CCA?DBD9#
@5A6
GCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTN
+
@CCFFFFFHGHHHIIGIJGIJJJJIJGGIJHEHHJJIJIJJIIIIIJJJJJHHGFHFFFDCDEDDDDBDDDCDEDD@BBDCCDDACCCDBD>BBCCCDDD#
@5A7
AGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCN
+
BC1DDDFFGHHHHJJIIGJJIJJJJJIJGIJJJJHJJJJJIJJJIIJIHIIJJJJIGGHHIJJJI:BDDCDDDDDD@A?BBDDDDBDDDDDBDDDDC>CC#
@5A8
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@@@FFFFFDHHFHIIBGGGIIIIIE?@F*?FCAAGGHB?FEHEGGCG>EEABHGIGGC@FHIDE;CEHHECEDBDDDFD@DD>@B=;CCCD3A:@AB?BD#
@5A9
GCTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATC
+
BC@FFFFEHHHHFJJIIJJFHJJJJIGIIJJGIJJJJJJIHHHGIIJGHIJIIJDIIHHEEHFFDDDEEEEEDCCDDAACCDBDD?CDEDDDDCDCCC
@5AA
CGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGN
+
@<?ABDDB<=<<?<8CF:?@DEAGD=CCBF@EACE=EBE<9;>;>;@=?AA9A9@ACCCCCA,:,:>C?:(3??@@?>4:>>4>@A3398??<>::>CC<#
@5AB
ATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
@@CFDDEFHHHHHJJJGIIIJIGGEHHFHFGGGGGIJJIGBDCHIJJIIIIJJIIEGGFBAACDACCDDDCCCDDDDDDDDDDB@BDCACCCD?C@CC
@5AC
GCCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJIJJJJJJJJJJIIJJJJJJJJJJJJJJGHGHFFFFEEEEDEDDDD8?B@DDDDDDDDDDDDDDDDDDD#
@5AD
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
@@@DFFFFDH?DFIDEHGIICAHEHHEICGEGEEEHFGEHIEGGGIIDFD=GGEIAFGEEGH=CEEFFBB@;ACCCC;?B>>;@CCCC:>ACBB?ACCC
@5AE
CAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTN
+
C@@FFFFFHHGHHJJJJIJJIIJJJIJJJJJJJJIJJJIJIGIIJJJJJJIHJJIJJIIJJIJJJJJIIIIJJJJJJGHJHHHHHHFFFFFFCCEEDDDD#
@5AF
CTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTN
+
@@@FDFFFFHHFHIGGIJIIHEDFHHIJJIGFHGIBGIHIGHEGIGB8@FGGHIFIJIGHEFHHFHFFFEFFCEECCCDBDDDDDDEDDDDBBDCC@>CD#
@5AG
GTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCN
+
@@@DFFBDHFHDDCFEFHGEHHIIBHIDIIGFHGHGIHGEHGCGIIGIGBGGHIGIGEII@GHEADEHHEEEHH@DDEFECAEAC;58?CCCCCCDCC?B#
@5AH
GCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGN
+
CCCFFFFFHHHHHJJJEHJHIIEGIIJJHIIJJJIIJBGHDGIJJJJJJJIJJJHHIJJJHJHHHHGFFFFEDDDDDDDDDBCDEDDDDDDDDDDDDDDD#
@5AI
CTGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAAC
+
CCCFFDDDGFHGHIGHGGIJJIIJDDDDDDDBDDDDDBDDDD>CBDDD7@ADDDDDDDBBBBD@B@DEDCA@B?BCDEDD:A@CD@C@<ACDD5>@CDC
@5AJ
CGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTN
+
?@@D?8DAA?ACC:ACAGICFBEEEECH@<AFHIEBCCHB???9FH??GDHIGEDB?<BFD888975-5AE8?BBCA9(5;@>;@@C:55,55>A5@::A#
@5AK
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@@@FDDEFHHHHHCFHIIIIJJGIIIIICHEAGGBGGDFG@FGFCGGCGHIGIGGGDHGGIJGEHHGIGEHIG;=BB@CC@C>CEDDDEDACCD@ADBBC#
@5AL
CTCACAGGCTTGGGAGGCTTGGGAAGCTTCATGCGCAGGTTCTCCAGCTGCAGGTTCTGGGAGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTN
+
CCCFFFFFGHHHGIIGIIIIJIIGHJIIJJJJGJIGIIIDFGGIJIGIJJJJIJ@EHFHFHFFF5?CEDDCCDDCFEDACDDDDDDDCDDDDBCCCAAC9#
@5AM
CTATGACCTCCTCTATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCN
+
BCBDDFFFHHHGHJJJIJJHJJIJJIJJIIIJJJGIIIJIIEHIIIIJJIIJJIIJIGGGHIIJIJIIHJHJHHGFFFFDCECEEDDD@ABDDDDDDDDD#
@5AN
GGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGT
+
CCCFFFFFFHHHHJIJJJJJHIIJIJIHIDGIHHIJJJJJJJJJJJJGHIJJJIIJJJJJIGHHHHFFFFDDDACDEDDDDDDDDB@BDDDDDAC>?CB
@5AO
CACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJIJIJJJJJHHHFFFFFEEEEDD>BDBDDDDDDDDDDDDDDDDDDDDDD#
@5AP
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIIIJJJJJIGJIJIGIJJJJJJJJJGHHHHFFBCDEEDDDDDDDDDDDDDDDDDDDDCDDDDACDDDDDDDDD
@5AQ
GTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTGGGGGTCATAAGAATGA
+
CCCFFFFFHHHHHJJJJIJJJJJJJJIJJJJJJJJJJJJHIIJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHFFFFFEEEEEDDDDDBBDDEDDDDDDD
@5AR
CTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
CCCFFFDFHHHHHIADGGGGIGEIIIFGIJIJGIICCHHIGJGIIJGIJFII==FIJGJJGIHIJJIJH:BBB@CDDECDDCBD@D<??<@CCCDDDC
@5AS
CCACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACN
+
CCCFFFDFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJIJJJJJJJHIJJJHHHHFFFDDDEDDCCEDDDDDDDDDDDDDDDDDDDCDDDD#
@5AT
GTCTTTCAGTCCCTTCTTTCCACTGAAAATCCTATGGATGAAACAAAATTAGGTAAAAGGAGAAAAGGTTTGCTCTTACCCCATTCCACCGCGTCCTCCTN
+
@?@DDDDBDD?DHEHGAG@IH@DCHBHHGIIIEHGB?GDGC@BHGDGAC9BGHFGFI>FI;BFBGCGHGGAHGIHH=EEABDE>C(;@@A;;:38?8@?9#
@5AU
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJFHJJJJJJJJHIJJJJJ;BHF>CEEEEDCCDDDDDDDDDDDDDDDDDDDDDDDD#
@5AV
CGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTN
+
BCBDFF@DFHHHHIJJJJIJJJDBDDDDDDDD<BDDDD5@BDEEDEDDDDD@BDDDD9BD<CDDDDCEECCDDEDDBBBBDDDDDDDDDDDDDDDDDDD@#
@5AW
GCCTACCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJIGJJJIIJJJJIJJJJJJJJJJJJIJGHIJJJHHHHFFFFFEEEDDDDDDDDDDDDDDDDDDDD@CDDDCBDDD#
@5AX
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTN
+
CCCFFFFDDHGHGIJHIIJJJJHIICHGHIJJJJIJJJJJIGFHIGHIIJIJIJGIIHHGGIJJJHHHHFFFFFFEEDEBD8=BCDACCD:CCDDDCD?8#
@5AY
CACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGN
+
CCCFFFFDHHGHHIJGIGJIJJIIIHIIJGIIJJJIJIJJJJJJJJJJGIIJJJJJJJJJHHHFFFFFEECEDB8=B@DCDDCCDDDDDDDDDCDDDDDD#
@5AZ
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@@@FDDFDHHGHGIEHIEEFHIJGIIHIEFFDFGGGHJIGIBH@?FFHGIGIGGGEGGH@GGIECH@DBHHGF;B>@>;@AAACCDCDDCDCCBDCDB+
@5B0
CGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGN
+
?1?DDDAD?C<CCBGFEGE?:CA?CBBHCFBEGIIE@F?FGFFIIFFFEEEFFFFDGEGEC@FEFA>ADAC>CC??B>,;;;;>ABB?B,5>A(>AA@AB#
@5B1
CTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
@CCFFFFDFHHHHJJJJJJDDDDDDDDCDACD@DEEEDDDDCCDDDDDDDDBDDDEDDDDDD>CDDDEDDDDDD>B@CDDDDDDDD@CCBCC:CDCCCC
@5B2
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGGAACTGCTCTN
+
@@@?DDDDBBD<?EEHGF@>F>EHG<<FG??F9?C?FGA<?DH@D9<<D8B/8=<BBCF=@7@CH--4?BD7;;@;(6;;C>>A:;;9>C(599@5>C>4#
@5B3
TCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCAATATTCAAATCATGGN
+
@@?BDDD;A:?=?CG:CAACFHBG<33AF<?FH>?C<C91?E9C?9:9BBGBDDC9BGFG:?D*?8DDBF@8CB==;87C4@;C=.7).7A=CAA>7777#
@5B4
GGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGN
+
CCCFFDFFHHHGGJJJJJJJJJ@EGHHJJJJJIDHHIIJJJJJJJJJJJJJJIHHHHHFFFFFFEEEEEDDDDEDDDDDDDDDDDDEDCDDDDDDDDDDD#
@5B5
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCFFFFFHHHHHJJIJJJJJJJJJJIJJJJJ?FHJHIJJIJJHIJIJJIJJHHHHHFFFFFEEEEEDDDDDDDDDDDDDDDDEDDDDDDDDDDDDEDDD#
@5B6
TGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
CCCFFFFFHHGHHJJJJJDDDDDDDDCDCCCCDEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDCDDBDDDCDDDDDDDCCCDCDCDDACCC
@5B7
CCCCGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
CCCFFDDFFHHHGIJJJGIIHHHHIIIIHIJJGHGIJGGIJJJJFHGIJJ;BHHHF;BDDDDDDDDDDDDBBDD>>BDDBDEDCCDDDDDCDCDDEDCD
@5B8
CTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJIJJJJJJGIJJJJHHHHFFFFFFEECECEEDDDD8?BD<CDDEDDCC#
@5B9
CCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGN
+
CCCFFFFDFHFHGIJIGIHHHHHGHHJJIFHIIIGIGGIJIJIIGHEEGIGCEEHDGGC@DGHFFEEBDFDDCDDDDCABDDD?A5:?@A@BBBDDCDDB#
@5BA
GTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCN
+
CCCFFDFDHDHHHIJJJIJJJJJJJJJGIGJJIJJIJJJJJJJJJIJJIDHGHIIJJJIIIIIJIHHHEFFFFD;@;@CDDDDDDDDDCCCDDDBDDDDD#
@5BB
GAGCATCAGAGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGCGGTCTGGTGGGTCAGAAGTTGGTGGG
+
@7@DDDB;DDFDHHBFGBHGG@CGEAF9CFGHCHGBE>GEDECHIGI<09BFDG@FHGCGEH?AHD7=AA(3205>??+38@&3<<:CC@AAC8?BB
@5BC
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATA
+
?@@BD>?DDFF??ACFADCFE?A<:3ACHHIICA?:EBBGAB8900B9?FBD>FCECAAHGEHHGGEE=@DAA??C;B=6;?CCC;;C;>@::@???>>
@5BD
CTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJHEHHHHFFBEFFEEE#
@5BE
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGN
+
CCCFFFFFGHHHHJJJJIGIJJJIJJJJIIJJIIJJJJJIJHIHIGIGIEHIIGIHGGGIJIIJJJIJJJIJGGHGHHFFFDDDADAD@CCBBBCCCCDC#
@5BF
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
CCCFFFFFHHHFHIJJJJJJJJJJJJIIIJJJJJJJJJJJJFIIJJJJJJJJJJIJJIJJJJJJIJJJJIJ=BHBFFFCEEEEEEEEEDDDDCDDDDDDD#
@5BG
CCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCN
+
CC@FFFEFHHHHHJGIJIJJIIJFIHIJIGIJJJIIJJJJJJJIIJJJJJJJJJJBFCHIIIFHJIGIGIJIIIHHGHHHHFFFFEDEEDDDDDDDDDCD#
@5BH
ATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCN
+
C@CFFDFFGHHHHIIJJJJJJFHIJJJIJJJJJJJIJJJJIJJJJJJJHIJJIIJIJJJIIJIIJJJIIEFFFDDDEDDFEDD;CBDDDDDDDDDDCDDD#
@5BI
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCN
+
@BCFFFFFHHHHHJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJIIFHJIIICGIHHHHHHHFFFFD>CEEEDDDDDDDDDD>CDDDDDDDDCEDDDDDD#
@5BJ
CCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGN
+
@@@DDADA?FCFFEFEFB<FHD?F?FA?C<FDEEGFD9?FGIE>8??DAF=FFFGIEFF;=@AEF9?CDB9>@@@BB?855<>;>A??<(4<39<>@BBB#
@5BK
TCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTG
+
?@<DDDABHA?AAB<<BFFHIBGGEGCCEBEBDE:EGGDHCFGBGCGHIIIIGIIG8BCHCGHG>FHA=D@DE>AE?=A
@5BL
CGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGCACTGGAACATGA
+
@@@DDDDDD8:CFF@CBAFH>EHDFA<ADFEFGDB:?@)9*0(?@<AFD68=<8??;?755>>:>ABBBA@?:@:3>>@7<9055>?8332+49?BA:
@5BM
CGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTN
+
CC@DDFFFFHHGDCFHIJIJJJIIJJJJJFJJJJJJJJGGHIIJIIJJHIIIIGIIJJJJJJJJJGIJJIGGHJIJJGHIFEEFFHFFFFEFEEFFCEED#
@5BN
GTGCTCATGCTGCAGGTTGGTGAGCAGCTCGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGGTGGGATCCTTCAGGGCCTTCACAGCCACAAGCATCN
+
?@@D;DD:D??:3;ACGBCEGEAEBCFIFCGFFEAFFIIIFIIEFIFFFEIF;@@6@<<;BB;@?65;=9@??:A>>@A88?@BB:4@BBB(9<@B@B@B#
@5BO
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCN
+
CCCFFFFFHHHHFHIJIJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJFHIJJGGII=FHIJGGIIHFHHFFFDDDDEEDDDCDDDDCDDBCDDDDDDDD#
@5BP
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
@@@DFFABFFFHHIGHIIGGIJJIIJJGJIJIJJGHIJJJJJCGGIIHIIIJHGHHEFDDCEEDDDDDCACDDDDDDCDDDCCDC>@B>CDCDDDDDCC
@5BQ
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGN
+
CCCFFFFFHHHHFHIJIJJJGIJJEHIGJIJJJIJJFGHEHIGGIGGJIIIIIIJJJ@EHGGGHHFEFFFFC;AEDDCBBCDDDDCD>CCDEBCACDDDD#
@5BR
GGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGN
+
@<<DFFFFHGHFDIJJJBHGIHIJGHFE<BBHIJFGICGGGIJIIDFHEFIIJIHGFGGIHCBFGGHIHIGIB@C@DGHHHGHHDCBCFCCEDDDCCCCC#
@5BS
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTN
+
@@@FFDFFFHGFGIIJIIDFGHGGCGGGI1CGDGGFHHDCHBHIJGHGIGIIIEGIAEE<BD?AC>@CA@>ACDCA?ACAADDDDCCCCDCACDBDDDCD#
@5BT
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@@DDDFADHHFDHFFHGFFHHIEIECDCF9CG@DHIGEFDFHHIIGHIFIEDDGGAFAGHIGH@EG>CACHD@DCC@CD;@8@,58?A@CDC?<(8@
@5BU
GGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
CCCFFFFFHHHDFIHIJGHJJJJIJJJJJFHIFHIIJJJJJJJJJJJJJIHIJJJJJJJJJIFHHHFFFFEEDDDDDDEEDDDDDDDDDDDDCCDDCDC
@5BV
CTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTN
+
@@@FDDFFHHFFHGHIAGHHIIJJIJIJIICHGGHIIJIGGIJEGGIJJJJIIGGGIJIGGIIJJIJIIIJJJDIIEIJGIJJJJJEFHFHHHFEFFCFF#
@5BW
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
?@@BDDDD>42ACD;BB??F?<:<F1:C:DFFFF9DE<B@BF@FFFC@FE@EI?4-:55;D;@6;AB;:;AA=;AB@D@B3,:::5::<B8:98ABB2
@5BX
AGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIHIJJJHIJJJJJJJJJJJJJJJIJJJJJJJJJHHHFFFEEEEEEEDDDDDDDDDDDDDDDDDEEDDBDEDDDD#
@5BY
GTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTN
+
??=DDD>;?AB<A@ABE+++A44?A<C@3CE>AA@DA<8?B?B*8=BC<)8=@@)87)7.)7;??>(=7;;;;?@@36@>>A:>>:555,55:(5>>:>A#
@5BZ
GCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCN
+
@CCFDB?DFDFFHIIIGHIJJJIGIBEIJJJIIFIIJJJJJEHJHIJAGHHHHHF@CDEEECBCDDDDDDD<CCDDD2<@BDBDDDDDDDDBDDDDDDDD#
@5C0
GTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGN
+
CCCFFFFFHHGGFHJIIJJJJJJJJHIJIJJHGIFHGJJJJIJJJJBGHIGGIJJGIIIGHHHGFFFFEEECEEDCCDDDDFDDDDDDDDDDDDDDDDDD#
@5C1
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCN
+
@C@DFFFFCFDFHJJJJJIJIIIIJIJIIGGHHGIJJJIIGHIIHGJGJJJIIGGIIHJGJIJJIGIJ=CEHCEFF,;AB;CCDCDD8<CCD@AA@ACDD#
@5C2
TGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTN
+
<@@DDDDDHHFFHIEHIBBGHAGE3CD<CADFGGIHIGDHEHDG?@F;'=FCAHI=CAEEAB?DE=C@CC?@?>CCCACCCCCCCACCCC@CC3>CCACC#
@5C3
CTGGGCTTTACGCTGACGCCGGCGGGGGGCCCGTGTCTTGGAGGCTGCCTTCTTCGGAATGTACACTGGCTGCTGGCAAACCTCAGAGGCCAGGGGCCCTN
+
@@@DDDDDH?BFD;@CB?@@FHGEGB?96BBB605A8>CC<@C7?AA?8@C9AC:87??<>3:(++4:<19??C3@<?CB?<C9>9>@0208?BBB9@BA#
@5C4
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJJIJJJJHJJJGIIJJJJJJJJJJJJJJJJIJJJJJJJJJIJJJHHHHHHFFFDEEED@CDDCDCDEDEDDDDDDDDDDDDC
@5C5
TAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGN
+
@C@FFFFEHDDHGJIFHIIJGGGECGGHIIGGGIIIIBGGAHE4BGIIHIJJEIIJJGIJJHHGHIIIIGGGEHHHHHFBBDFEECCDFEEBBDDDBCDB#
@5C6
CTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTA
+
CCCFFFFFHHGHHJJJJJJJJIIJJHHHIJJJJJIIIJJJJIJJIJJJJJJJJJGHIIJJJGIJIIJJGIIIIJJJJJIHHHHHFFFFFFCEEEEEACE
@5C7
CAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGN
+
CCCFFFFFHHHHHGHIIGHHIJJJJJIJHJJJJJJJJJJJJIJJJJJJJJJHHHHDFFDEEEEDDCDDDDDDDDDDDDDDDCDDDDBDDDDDDDDDDD@C#
@5C8
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHHHHHJJJHJJJJJJJJJJGGIJJJJJJJJJJJGHJJJJJIJJJJJJJJJJJJJJJJJJHHHBFCEFEEEEEDDDDDDD<CDDDDDD8ABD
@5C9
TTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCN
+
@@CFFFFFHGHHHJJJGHJIIJIIJJIIIJJJJJJIGIIJIJJJJJGIIJIEIJJJJJJJIJFIIGHGGIIJJJJJIJJJIIHHFHHHHFFFFFFDCCEE#
@5CA
GGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTN
+
8;?DDD?BHHFFDHDCFEGC>EFGII@BBB?ACCCA8>C3>BDECC@<9>?B?@/<?BBCC@C@CCCCC>@CCCAA@C:<B0-9C:CB:>>>>(:9ACC4#
@5CB
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
CCCFFFFFFHHHGJJJJJJJJJJJJCGIJHIJIJJJBGIJJJJJJJIJJJJJHHHHHHFFFFFEEEDEEDDDDDDDEDDDDDDDDDDDDEDDDDDDDDDD#
@5CC
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGN
+
@@@DDDD;AAD?CGIFIEFGI<GI@EFFFGI9FGIFI>?9?DDDFIIEBFG3?/?DFFF@EFIIECFID>EEAEA?BB@B.;@CCCAAA>@;@B(((::A#
@5CD
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTA
+
?BBFADDDFHHHHIGGHIJJIJIIJJJJJJJJJJIIEHHIGGHJIJJIJJIIIIGIJIHHHHHHFFDFFEEECCC?BCCDCCDDDDCCDDDBB09@@<A
@5CE
TCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGGAGTGTN
+
@@<ABADDA?F?BGEA@?<F@GICF<CA?::EHHADFHBCGE<GGIBHI??9?F<*9CFH<F<=FHI=EAGD@E4.?E=)7);.7)>CCC?5;?',8(,:#
@5CF
TAGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJ7BHIBHHHFFFDFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@5CG
TCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTN
+
CCCFFFFFHHHHHJJIJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFDEEEEEDDDDDDDDD#
@5CH
CGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTN
+
@??DBDDDHFFHFIIIJJJJGGHGIIJJIJIJJEEGHIGFHIJJEIGBFGIDHIIIGGIIIJJIJEEEGGFH3?=ACFCDCCDDDB@ACCCDDDDDACCC#
@5CI
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
CCCFFDFFFDHHHGGGGEIIGIGGIHGIGGHIEGGHHIFEIG0@FF;BFHIEE@CDHIHGD?BBEDDDCDDDCDC>CCDDCCCBCCCDCCCCCDDCDDCD#
@5CJ
ATCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJJIJJGIGGIHIHIJJIJIJJJJJJJJJJJJIJIJGGIHIJJJJIJJJJIJJIJIHHGHGFFFDFFDDD9?BD8CDDECDCCDDADD#
@5CK
TCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGGGAGAGGCACAGGAGATGTC
+
?7?ABBD:@?+:?A<A@E<BFCFGICCA@?CFFCC>B@FF>4?4?DDC4BGIIF'5=;@:=7?E>;>7);))7?;@>>?''3388(2?8<?88?8(4++
@5CL
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTN
+
@@@DDBDDFHHFFBE@FHEE??FBFH>EFEFGHGHG):C:?@FEHB:@GH;;@CEHI@@C(6??D?B(6>CBBCC5>:>C?CC>C,<A:4@:CCCC4>AC#
@5CM
CTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTN
+
CCCFFDFFHHHHHJJIJIJJJJJJJJJJGJJJHJHIIJJJIIHJHIDFHIHHHJJ?DFHIJJJJJIGIJJJJJIJIHGGHGFFFEFFDEDEEEDDDDDDD#
@5CN
CCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGN
+
CC@FFFFFHHHHHIJJJJJJIJJJJJJHHIJJJIJJIJIGHIIIJHHHHHGFBDFD9A@DDDDDDECDDDDDDDCDBBD<BD<AB5ACDDDDDDD:AB@B#
@5CO
TGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTN
+
BCCDFDFFHHHHHHIGIIIJJJIJFHIGHIHIIIJGIJIJJJJJJJJGIJIFHIIJJJJJHHHHHFDFFFEEEEDEDDEDEEDDDDDDDDDDDEDDDDDD#
@5CP
CGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATN
+
CCCFFFFFHHHHHJJJIJIJJJJJJJJJGJJJJJJ?FHJHIJJJJJFHIJJJJHHHFFFFFDEEEEDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDDE#
@5CQ
CACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCN
+
=??+4=D?D?CDD<:2A3+:;B<33@9:?C3*:?DDDE>?9??DDB/07@5@@7=>C?A?7(;;;@66>>>>?6=?<>:5(9>>A(4(&&09>?4::>A>#
@5CR
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
@C@DDFBDDFDDHIIIAF>DFBFEGIIIGGE@FGDGFHGHEHHIIGGGDHDHCCDFH;FG@FEGHE@ECCCEEB5;AA>;@BCCB@BCCC@CCCCCB?<<#
@5CS
TACTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGA
+
@@CDDFFFHHHHGJIJJJIIIHJJIJJGHIJIIJJJJJJJJJIJJJJGIJIJJJIIIEGIJIJJJEIIIIJIIIJJJIIJHEFHHFFFFFFEDEEED@@
@5CT
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@CCFDFFFHHGHHJIGIGIIIJJJJIIIGGHIIHIJJJJHGDHHIIIGGIIJEHEEF?CAEDDEDDDD>ACBDDDDCCDDDDDDCCDDDDDDDDBAADD
@5CU
GACAGGACTCTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACGCTGCCACTGACGGAAGTTCTCATAAACGTCCTTGGAAATTTTGGAGCGGTCACCTN
+
CCCFFFFFHHHHHJJJJJJHIJJJIJJJJJJJJJIJJJJJJIJJJJGIJJJJJJHHHFFFDEEEFEEEDDDDDDDDDDDDDDDDDDDDBDDDBDBDDDDD#
@5CV
CGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGN
+
CCCFFFFFHDDFFGHIIJGHIHIGJJIIJJIFGHJIJJJIGJJGGJHIIJIJJJIIJIIJGGHGJJIIIJGIHFHFEHFFFFEAEEEEEDD;>?8@CCCD#
@5CW
CTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGTTGN
+
CCCFFFFFHHHHFIJJJJJJJGGIJIJJJJJJJJJJJJJJJJIJJJJJJJIIJJJHHHHHFFFFEDEEEDEEEDDDDDCDDDDDCDDDDDDDDDCDDBDD#
@5CX
AGGCGATCTGACTGGCAATGTGGAGCATTTGGGAGAGCCCCAGCTCACCCTTGGCCTGGCGTGGCTGTCCATCCACAAGGATCATTGCATCTGGCCCATGN
+
?<@DDD@B;??FFHBFFBGICBDE@GF<FEH@D=FICDGF???FHH<CGGGAHD;C=;;A=44'3>?A>CCDC?@CCB((9(:<A@:>C@>C>AABBB>9#
@5CY
CACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACN
+
CCCFFFFFGDHHFIIIJJJJJJJJJGIJJJJIGHIGIGGIIJJJJJJJJJIHIJHHDFFCEEEEEDDCCCDDDDDDDDDDCCDDDDCDDCCDDDDDDDAA#
@5CZ
GGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCN
+
BC?DFFFFHHHHHIIJJIIIJJIJJIJJIIJJJJJJJJJJIJJJJIJJJJJ@GHEHFFFFFDDDDDDDDDDDDDDDDDDDB>BDBDDDDDDDDDDDDCDC#
@5D0
CCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGN
+
CCCFFFF@FHGHHIIJJHHIJJBFHHIIFHIJJJIIHHHGFFFFFEDEEEDDDDDDD?B7ACCDDDDDDDDDDDDDBDDDBDDDDDDDBDD8@BDDDDDD#
@5D1
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
@C@FFFFFGFHDFGIIFHIC9CFGIIIIIIIIIIIIGGIIHIIIGIIIIIGIIEFEGGEHEHHFFFFDECEEEEEECDA@BDCCCDACDDCCCDDCD??C#
@5D2
TTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCN
+
@?;DDAD;FBDF?EAAA?FHDHII?CHHIIIGA>F?FD?FFHGHGGIIEGDGEIGGADBG?BCHCDHGIBFHC7@7=EEAHFCEECBCCBECA@CDACCC#
@5D3
GCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTN
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHIJJJJHHHHHFFFBDFEEEDCCEDDEDEDDDDDDDD#
@5D4
CCCAGTGTTAGTGCCATCAGCTCTCGTGAGTGGTACAGGACTCTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGA
+
CCCFFEFFHHFFHGGGHGIIIIJJIJIJFGFGIGHJJJJJJJJJGIIGJIJHGGFGHGFIH@BGIHHHHHFEFCBDACCEECBDDCCCCEDDCDCDCDA
@5D5
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
@@CFFFFFHHFFHIGIGIIIIJJJIJIJJIJJJJJJIIGJJIJJIJIJJIJIJJIIIGGHGHIHHAHFFDFFDEDAEEDCDCDDDDDECDDD5<BDBCDD#
@5D6
CCACAGATCACTGGGATGCCCTACGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGN
+
@@@FFADEHHHFGIGIGEHIJDGEHIBFGGGIJIJIIIEDGEGGDAGIGIEGDGIIJJIGEGHIIIIIHFD@BEEEACCBBBDDC:?CDCCCDDDD?A>C#
@5D7
CGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJHIJJJJJIIJJIJJJJJJJJJJJJJIJAGIJJJHHHHHHFFFFFFDDDEDDDDDDDDDDDEDDDDD#
@5D8
GTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGN
+
CCCFFFFFHHHHHIJJHJJJJJJIJJJJJJIJJIJJJJJJJJHHHHHFFFDEEEEEDDDDDDDDEEEDDDDDDDCDDBDDBCDDDDDDDDDDDDDDDDDD#
@5D9
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJCGIHIJJJJJJJJJJJJIJJJJJIIJJJHHHFFFEEEEEEDDDDDDDDDDDDEEEEDDDDDDCDDDDDDDDD#
@5DA
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
@@@DDD=DFHHHDBHACDEGHGAFGGCGCEECHEFFEGB@HGEHAFHIDHIIIIGIIIGIFF)==@>CE>?BAC@ACC>CC;A>>ACCCCCBB?CBBB(5#
@5DB
GGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGAAGTGCAGGGGATGGAGACAGGGCGGCACTAGGTTTCATGCTCATATCCGGTCCCGGCAATGC
+
@@@FFEFDDHHDFIIGIIHHHJJGHGGGIGGGCEGHIFEGGIJIJGIIEIIGHHEAEFD@BDDDDCD>ACDDE@CDDDDDEDEBD<@BDBDBBBA>C
@5DC
CAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTN
+
?;@=B?;:A8:ACA@FGGBHHFH9ACH9FFC?*9??076?4=@8=).=C@@9CEEEF?7==7;;@DC?C.;AA((5(;95:35(;>?@5?-2:+:B:::A#
@5DD
CCCATGATAAGGAGATTGCCTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTTTCTAGCAATGGGAAGCAACCTTCTGN
+
@@<?DDDDDFH?DHBGGIIIIIGGHEGBCFE@8?GGIIIF@GHIIIIGHGIBHIIIIIE@E@EEFEEEEDEDCCC>>C@;ACCCCAB???BC?BBCCCC@#
@5DE
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGN
+
@@BFFFFFHAACDFFHIJJJJJJJJJJJJIJJJJJJJGJJJJJIIIJJJJJIJJJJJJHHHHHHFFFDDDDDCCCDDBD@CDDDCDCDACDDDDACCDDD#
@5DF
CCCAAATTAATCTGATTTGTGGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGTTTTGATTTTCAAGCACTGCCACTCTGTTTTCTN
+
@@CFFFFFGHGGGIAFEHIJHJJJJGHGHHJCFHGIIIE?FHHGIIJHFEFGIJIJICHGDGFCGHIHJIJIGDGGIIJHHFC@DEFFDEEDDCCCDDCD#
@5DG
GTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCAC
+
BBCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJHHGHHHFFFFF
@5DH
GCCCCTAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTN
+
@@@A1B=BDDF83AA?CGA<ADFE99<C9GF>BD3CB:DE<D4??<9:B?1:F:A9<FF7.=F)7=C@E@E?CC?);77;@3>A>@>AA;>A>A@BABB,#
@5DI
TCCCTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGN
+
@CCFFFEFHDFHHGGIIIGIJGIJIJJJIIIIJJGIJJJJJGHIIIGHGGIHIJJJGDHHGIIJJIIII5;BEHHHHH;BDEFFFCDDDBDDDCEDEDDD#
@5DJ
CTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCC
+
@@@FDDFDHHFHHIIGE?FE@DHAECCECA;C@BFGE9BB?BBGHAGHDGIGCHI<FGCDHGAEGHEFEFDFCCCC>ACCCCC=ABBC@AB?BBCCCBB
@5DK
GTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGAGGN
+
@;?DDDDDFFBHHIG@GGGE>GHE:C:1?E8?FHIIGCHA*8B?BFFGAAGGIFECEC8?9A39?CCCCCCBB?BCBB@@:>ACCA>?@@C?CBB2<?B@#
@5DL
CTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAA
+
CCCFFFFFHHHHHJJJGIJJJJJJJJJJJJJJJJJJJJJJJJGIIIJJJJJJIJJJIJHHFFFFFDACDDDCDEFEEEEDDDDDDDDDDDDDDDDDDDD
@5DM
CTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTN
+
@C@FFFFFHHHHGJJJJJGJIJJIJHHIGIIJIIIIIIJJIGIIJJIHGIIJJJJJDHGJIJJJIDHHGEDDFFDDEEDDCCCDDDDDDBCEDDCDDBBB#
@5DN
TAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTN
+
@@CFDFDFHGGHGGIIIIIIJJJJIIJJJJJJIJJJGJJJJIJJJJJJJJIIJJJJIIJJJJIJJJJJIIGIJJHHHHHHFFFFFFEE@CEEEEDDDDDB#
@5DO
AGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGN
+
CCCFFFFFDFHHHJJJJJJJJJJJJIJIFJHIIJJIJJGHIIJIJJJJIJJIJJJJJJJJJJJJJJJJ@EHHHGFFFFEDEEEEEEEDCCDDDDDDDD@D#
@5DP
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
@BCDDFDEFHHHGIJIJJJJJIJJJJJJJIJIIJJJJIGIGGIFHIIEHGIJJIJJJIJGGIJHFHHHFFFFFED@CECDCCCCDCCDDDDD0<BB9CDC#
@5DQ
GTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
@?@DDDDA?A?DH8:CBFHB9EHHCGFCFH6?DGGB@@DG9?B@DFHDBFHBF8CH=CFFEHIEH@>A;5);???BC;6.6(->@C>B?='3<<5@9:@
@5DR
CTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGN
+
@CCFFFFFHHGHHJHIJJJJJJJJJJJHIJJJJJJJJJJJIIJJJJJJJIJJIJIJJJJJJJHHHHHHHFFFFFDD>BDDDCCDD@CCDDCDDDDDDDDD#
@5DS
TTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTG
+
@@CFFFDFFHHFHGFIIIIJJJJ@FHGHIFICHIIJIHIJJJJIJIJJ=FFHIJJJGIGIIGIFHHHFFFDFFFFDBECCEDACDDDDDDDDD:>CCCD
@5DT
CGCCCCAAGAGTGAAACTCCATCTCAAAAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCN
+
@@@FFFFFDHFFFHGHIGGAEFHIIDIIEICEHAFHIJJIIIGCBGEHIIJFFDFDBCDDB?BD@BBBBBCDCDDDCCD<>:44:>:ADDDEEDC<ABBA#
@5DU
ATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTC
+
CCCFFFEFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIIJJJJJJJJJJJJJJJIJHHHHHHFFFFFFFEEEEEDDDDDDDDDDDDDDDDDDD
@5DV
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTN
+
B@@FFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJIJJJJJJJJJJJJJIIJJJJJJJJJJJJIJHHHFFFFFEECEEDDEDDDDDDDDCCDDEDDDDD#
@5DW
GACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJIIIIIJJJJJJJJJJIIIIJJJJJJJJHHHHHHFFFFFFDDDDDBCCDDDDDDDD
@5DX
TCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATN
+
CCCFFFFFDHDHHJIJJJJJJJIGIGIJGGHIEIICGIJIGIJJJJGJJGHFEHJEHIJBHFHFFFFDDDDDDEECEDDDDDDDDDCCCDDDDECDDDDD#
@5DY
CTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATA
+
@C@FFFFFHHHGGHIJJGIJJJJJIJIIIJJJJJJJJJJIJJJJJJJJIJJJIJIIIJJIJJJHIFIIIGIIGHJJEHIJJJGHHHHHFFCDEDFEDEE
@5DZ
CGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGN
+
==?1=0BACBD>:22A:23,3A:CEFI>):::D:?6@58C;77@CA.7@).=C==.7;A>;;A6=@ABB3--(-5(,5;;(55(5>5=(+44+9(+::<5#
@5E0
CCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGC
+
CCCFFFFFCFDHHIHIGFHHDGGIJJJGHGFIIEIIEDHIGHJJFGHGIIGIIIGGHIJIIGHIIJFHGIJIIJHHHHHFFFEFFDEC?.;?BCDCC@C
@5E1
GCAGGTGCTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATN
+
C@CFFDDDDHBA?FG9EFHIDGGEBFEHH<CFG?EHEDHC?FBFFHIEEHHGIGG@GCFGC@GE@@3@;EAEEHEEFDFFEC?ACB@BCCC@CCCCCCCA#
@5E2
GGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGN
+
BCCFDFFFHHHHHHIJJJJIJJJJJJJIHIJJJJHHHHHFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD?BB#
@5E3
GTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGN
+
BBBFFDDDHHHHHJJJJJJJJFABB@BDDDD7BDDDD7<BCDEDEDDDDDBBDDDD<BD<CDDD@CDEC:CCDDCDDDDDDDDDDDDDDDDDBDDDDD:A#
@5E4
CTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJFJIIHHHHHHFFFFFEEFEEEEE#
@5E5
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHGHHIJJJJFHHJJHIJJIJJJJHJJJJJJJJJJJIJIIJIJJJIJJIIJJHHHHHHHFFFCEDDACDDDDDDEDEDDDDDDDDDDDDD
@5E6
CCCATCTTCATCCTCAACAGAACCAGAAGGACTTGAGTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCTGCATCTTCCTCCTCTTCCAAGGCCATGN
+
C@@FFFFFHHHHHJJJIJJJHGJJJFJIJIJIIJJJJGIIJJIJJIJJJJJIJGIJJJJJJJJIJHHFDDDDDCCDDDDDEDDDDDDCDDDDDDDDDDDD#
@5E7
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJHJJJJJJJJHIIJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJFHHGGHFFFDDEDCCCDDDDDEDEDDDDDDDDDDDDD
@5E8
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
@C@FDADBFBFFFBHGHEFDHC@DHHGEGHGHIIIGIGIIIIG<@@FGHDHEEHFF??C4<><?CCCACCCCCCB@@ACCCBACCCCCCCB?BBCCCCCC#
@5E9
GTCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCN
+
=1:B1BAD>>DDDAEAB?EE+CEBC>FFIIFEIEEEIDD?DDEEIAECDDEDD=7(-=A@;A@A>A26=?>AAAA;??>AA?<(888<<>?A94>A>>AA#
@5EA
CTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGN
+
CCCFFFFFHFFHHJIIJJIGIIIJIJGGIGDHIIIHIGIEIIGHHGIIIEEHECCEEFFF>;ACC@D@DCCDCDDADCA?BABAB<ABDDDDDBBDDDCD#
@5EB
CTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTN
+
:?:=ABD?FHAFAHGGIGI9EHGA@DHG@FH8B>FD)8.=F=85=94?CC>CCD;;<A>?5,5,5:AC44@>CADADCA::>@>)8@<@7B<A3:+>:>A#
@5EC
GGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGT
+
@@@FFFFFDFDFHIGIGJJJJJCGGGFHIHGHDHGIJIIIJJIJJJGHHIIIGGIJJJJFGGFHFGFFFFDEDACECDCCCDDDDBB<BDDCDCD@CCC
@5ED
CTCTGAAGTCCTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACN
+
BC@FFFFFHHHHHJJJJJJJJJIGJJJIHJIIJJGHIIJJJJIJJIJJJJIIGIJIJIHHHHHFFFFFEDCEEEEDDDDDDDACDDDDEDDDDDDDDCDD#
@5EE
GACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACA
+
@@@DDDADDHBFDHHIIIIGGHIIIAFHIIGIIIIFGGIIIGIFIIIBFGGHGGIBDGHIGIIGGIGGGIEHCHIHFFEDEEEEEECC;>AACACCCCC
@5EF
GGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCN
+
<@@DD<DD<FDDCGEHEDBFHG@F><F9AC29??FDHIIEEECGDB>FEHCGHG;2BFABHIEEHB97=CEHCHDHCHGHECECA?@@DEEE:;;;6>A@#
@5EG
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
C@CFFFFFHGHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJJIIJHHHHHFFFFFFFDDD9=BD@DDDEDDCDDDDDD#
@5EH
GTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGN
+
@@BFFFFFHHHHFIJIJJJJJJIJJIIIIIJJJJJJIJJGIIIIIIGIJJJIJIIJJIJJJJJEHIJJJGJJGIIGFDHGGGD@EHHGFEEHH@DFFFFD#
@5EI
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTN
+
?@@DD?DAH<DFD?+AFG@<FB>EA;CGGFGHG>*1CGE<DFA@GH)?;@-/7774@7@CHHFBB?A1;A:55((;:@>:ACCC>;984>@A:@>4:(:>#
@5EJ
GTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGN
+
B@@FFDDFHHHHHJIIIGIJJJJIIJIJJIJJJIJJJJIHIJJIIJJJJJBHHHHIEHIJJIIGGIFHFGHEFFFFFEEEEDBDDDDD(;B3?B9BCDDD#
@5EK
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGN
+
CCCFDDFEHHHHHJJJGIIIGGIEHIIIIHIJBDDFFGGGIJIGIJJJGFHIGGIGHGIIJJIIIIIJJIHHEFFFB>ACCCEDBDDDDCDCDABDDDCD#
@5EL
TGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTN
+
@@@DDD;DA2CF:??AFGHF6@:FE><E9F9?FF9GG@FAEF==(77=@B;@>)(6'33;;8<@?BBA>:>:A>:4:>@B:(:+:4(:4+4>AA:>BB@A#
@5EM
ATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGA
+
CCCFFFFFHHHHHJJJIHIJJJHGIIJIJJJJJGHIIJJJJJJJJGIIJJJJJJJIIHHHHHFFFFFDDDDDDDDDDDDDDD39@5ACDDCDDDDDDDD
@5EN
GTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFDEEECEDDDDDDDDEEEDDDDDDDCCDBDDDDDDDDDDDDDDDDDDDDDD#
@5EO
CTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAAC
+
@C<DFDFBHG?AFHIIBBGIADEGIGCHGFBEBFHIIDG<FB?FFHDHAGAGHA?F3C@/8CFHIGGFHCHH@C>CEEEHDBACEFEDCECDCCCDDDC
@5EP
CGGGGCACAGGAGCCGGGGCCTGCTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGG
+
@BCFFFFFHHHFFGIIIIJJJJJJJJJJJJIHIJJGGIJ@FHIIJJHHHGGCEEFFFFDEEEDEEDDDDDDDDDD<BDDDDBDDDDDDDDBBCDDDBD
@5EQ
CTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTN
+
@@@FFBDDDHFHHEBHGGIIGHGCGHGFIGIJGIIGGCHGIBEG9CGEDEHHHBFIHHGHIGEJGEGFCGGGIIJIJJIJJIIGGFEEHFFFBACDCCDE#
@5ER
GTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGN
+
CCCFFFFFHHHHHJIJJIJJJJJFHHIJHGIJGHGIJFHIIIJIJJJGIJJIJIJJJJJJEHHHFFDEFFCECDDDDBD(:ACAC@ADCDCDDDC@@@CC#
@5ES
GGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATN
+
??7BDADDDDDDFEE++AC@+A3A49FFEEEA<:<EDD;<DEDDD3B;DDC?DEEEAC=>CEEIE@EDDI@ACCA?;;=@5;;@A??>;>AAAAD:((,5#
@5ET
GTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGN
+
C@CFFFFFHHHHHJJJJJJJJJFHIJIJJJJJJJIJJIIJJJJIJJJIJJJJIIJIIJJJJIIIJJJJJJJJJJIJJJJJJIHGIJJJJJHHHHHHFF@D#
@5EU
CCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATA
+
@@@DBD4,AC=?BB?EH:CDEF@BF<FHEGIEHGIEHII>FGICG4B;?DDGG<A<>FDEHE=CAGH;CEA>BBEECCCCBACC@BC?>>C>@BB?>@
@5EV
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
@@@DDDADFFFDDGFAB8?F>FFG?G@BDF>@B;FF@DFFBCFFEEICEFFFEECFF?E@?;;7@ACCCCBA>@A>BBBABBB?@ABB<>BB@@ABBBB4#
@5EW
CTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGAC
+
?@@DDDD>4AA++<:CF3CEHECHFBEEF?BD>CDA**?3:*)0)?D8BFCFDF@=CF@)=@).=@)((59(;;;;>(.3@;??>>@>:,5:5>((;4:
@5EX
CCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGN
+
CCCFFFFFFHHGHIIJIJJJJJJIJJJJJJIJGIJEFHGHIIIJJJGFHGHIIJIJJDGHJJJJJIJJJFBHIGGHHHDDFFFFFDDDBBDDCDFDDDDB#
@5EY
TAAACTAACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAA
+
?@@DFDFBHFHHGJIJEHGGDGGJGGGFFGCGHIJJJGIGHDIAFHHIIGGHIJJJIJJJJJJDHHG:@AGFHHFEH?<?@;>CEEDDDCAACCDCCDD
@5EZ
GTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCN
+
C@BFFFFFHHHHHJJIIJEHIIJJJJJJJJJJJJJIJJJJJJHIJJHIJJJDHIGHIIIIIJIIJJJJIFHIIIJIJJGIJJJGHHGHHHHFFFFFFEED#
@5F0
GAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGG
+
C@CFFDFFDFDHDIJJJJIJIJIJJJJJJGIIJJJJJJGIJIJJJIJGIIIJJIHHHHEHFFFFFEECDEDBDD@BDDDDDDDBBDDDD
@5F1
CCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGA
+
CCCFFFFFHHHHHJJJIJFHIJJJJJJJIJJJJIJJJJJJJJIJJJJFHGIJJJJJHHHHHHHFFFFFDDDDDACCBAB?DDFEDDDEDEDEDDDA@DD
@5F2
CTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTG
+
CCCFFFFFHHHHHJJHHJJJJJJJIJJIJJJJJJJJJJHIJDGIHIJJJJJIJJGHJJJHHFFDDDDDDDBDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@5F3
CTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTN
+
CCCFFDFFGFFDHIIJGIIGEIJGGCGHIIIIGHJIJIIJIIIIJIIIICGIEEHGHHIIIGGGIJGCGGGIIFGEGIJFH=CCBBD@@CFCCEEEEECD#
@5F4
CTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGN
+
CCCFFFFFHHHHHIJJJIIIJIGJJJJJIFDDDDDDDEEDCDDDDDDDDD5BDDDBDDDDDDDDDDDDDDDDD;BBDD>@BDDDDDDD5>?CDEDACD8>#
@5F5
CCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGN
+
CCCFFFFFHHHGHJJJJJIHIJIJIIJJJJIJJJJJJJJJJJIJIJIJJJJJIGHHHHFFDDEDDDDDDDCDDDDDDCDDDDDDDDDDDDDDDDDDDDDD#
@5F6
ATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCN
+
;=?A??DD8F:ACFGGCDH@F@<CFFAGFGFBGG?FB9:9??@8?FHGB@@=.7).(7AA?DECECC@;>A:33;9?:A((,(>C450082@:39>C?9>#
@5F7
CCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGGGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTN
+
<;:;?BBAF<BFFBHAEFH@B@<:<BB?FHB9)11)?DED@DGH<<BFD<FA@;58/==77@=);.=?7?C3??>.(6>3>(;;;@AA35((,<?C?BC>#
@5F8
CATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTGCTTATCTTTAGCCTCCAATTATCTCCTACTTCN
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJIIJJIJJJJJJJJGIIJJJJJJJJGIIJJJJJJIJJJJJJJJJJIJJJIJHEIJIIIGHHHHGHFFFBDFEC#
@5F9
GTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGN
+
BBBFFFFFHHHHHJIIEHHIJJJJIJJIJJJJIJJJJJIJJJJJIJJJJHFFDDCDDDDDDBDDDDDEECCDDDDDDDDDBDDDD@BDDDBD>><BDCDD#
@5FA
CTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCN
+
B@CFFFDFFHHHHJJJIJJJJJJJJJJJJJIJJJJJGFHEEHIHIJJJIIJIJIJIIGHJJIIJJJJJJIIIJJJIJJJHHHHHHHHFDFFFEEEEECCD#
@5FB
CCCGCCATGAGCTCCAGCAGGATGAACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGN
+
?@??BD?DHBF3<::<F;9FHI<G<CBF:)6?@FG>6;@@@=7C;:EH?DB>C?=A;?>>3;8;B5CC:C@DA:A@CB0?BCCAA:>>>C>:@@:>CCC?#
@5FC
CAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTN
+
@@@DDFDFAFHDFGGIIIGG@AFB69@AC>@CCCCCCDD@CCCCA@CCB<BBBB?8>>CDCCC@CC>CC>@@@C@AB><@BC>CBC??CC@A<AC>ACC4#
@5FD
GGTTGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGN
+
@@?DDFFFHHHHHIJJJJJJJJJIJJJJIJIHIJJGIIIJJIIJJJJJIIGHIIJJJJHHHHHFFFDDACDCFFDDCDDBDDDDDDDDDDDDDDDDBDBD#
@5FE
TCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGG
+
@@<DDBD;FHFB?FHECAF+AAC<CEGII6@:?BGGGBDGCHIG@GF<EHCEEEB?<;=6;?C@>CDC;>ACCC9?8@B<>@5?2<C@44@8<95.55
@5FF
CGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGN
+
@@CFF@DDFHHGGGHIIIIIIIGDGFGHIIFGGIIIIIDFHGIIIIIIIIIIIIHFDDDDDDDDDCCDDDDDDD5@@DCDDDDDCCBCDDDDDDDCBDDC#
@5FG
CTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTN
+
CCCFFFFFGHFHHJGEGBGHHIJIIIGGGII@HIJJIGIJJ;::DGBFG9@GGHFFDD>9B<FDBFGGGIIJJIHEGAHGGCC?E?DFFC;;@A@DCECC#
@5FH
CCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJIJJJJJJJJIJJJJJJJIIJJJJIJHIIHJIJHJGIIGGGGFEHHGDFFFFFFEEEEEEDDDEDDD?BBDD#
@5FI
CCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACN
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJHIJJJJJJJJJGIJIJJJJJJIJHIJJJJJJJHHHHHHHFFFFFDEEDEDDDDDDDEDDDDDDDDDD#
@5FJ
CCTTAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
@@CFFFFFHHHHHJIJIIJJJJJJGHJJJJJJIJJJJJJIIIJIJJJIIIJJJIEEHFFFFFCCEEEEECCDCCDC>CDCDCDDCCDCDDDCDDCBACDD#
@5FK
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
CCCFFFFFHHHHHJJFHIJJJIHIJIIGJJJIIJJJJIJJGIIIJJIIIJJJJJGIIJJJFIHHHHHFFFFFEE>CDDDDDDDDDCDDDDDDCDD9A@
@5FL
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
CCCFFFFFHHHHHJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHHFFFFFFEEEEEEDDDEEEDDDDDDDEEEEDDD#
@5FM
CTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTGTCCCCCTTCCACGGCCGGCC
+
BCCFFFFFHHHHFIIIGGIEHJIJJJIIJFIJJGJIIJJGGIIFHGGIGHHIIIGGFHHHHGFFFFFFEDEDEDDDDDDBDDDDDDDDDDDD
@5FN
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHHHJJJIJJFHHJJJIJJIIJJJJIJJIJIGGJJJJJJIJJJJJJJBGHEGIEHHHFFFFFFEECCECBD>CCDEEDDCDDDDDDDDCD
@5FO
CTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCAC
+
@BCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJIIIJJJJGDHIJJJJJJIHIJIJJIJJJJJIJJJJJIIJJJJJJJJGHHGHGHFFFFFFEEEEC
@5FP
CTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCN
+
@@@DDD?B>D6?FGECHGBCH@=;A?C;AE>BDD3;>CCDD@AC??B;5>A>@CB=<8@:>C?<?CBCAC@C<89?9@CCCCCCCA:@AD>@BBB5?B8>#
@5FQ
ACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCC
+
<@@DDFFAADDAHIIGHIIGCF@GFHCHFCDBGBG@FEFGCB?DAHGGHCE1@F;.8BFEAFG;=@DDA?AA9999;:?CAAC;:<A<@>B?B?>>>?B
@5FR
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
CCCFFFFFHHHHHIIIIJJJJJIFJJIJIHIJGJJIIIJJIJIGIJJJJIJJIIIGHGIJJJJJJJJIJIJJJ=EFDFFEDEDEEEDDDEDDDDDDDDDD#
@5FS
CGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCA
+
@@CFFFFFHHHHDHIIJJIJJJIIIJJIGJIJIJJIJIJJIJIIHIGJIJIFGHIIJJEHIIJJJIJHCEFFFFEEEDEEAADDDDDBBDDDDDD
@5FT
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTN
+
CCCFFFDFHHHHHGIIJIJIJGJJJHHHIJIJJIIJGGHIJJIJJJJIGIJJJII?FEGFEHCEGHGIJIFHHGHGCEFFD@CDBDBD>@BCCCCCDCCC#
@5FU
CTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTTTTTGGTTTGTTCTGCTGGGGCTN
+
CCCFFFFFHHHFFJJJJFHHIIIFIGIJIIJJJJJIGGJIJJJJJJJJIIFHIJJJGIJGJJIGHEHHFHHDFFFFFDDDDDBDDD?BCAD@@@ACBB<@#
@5FV
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
CCCFFFFFHHHGHJJJJJHIJJJJJJJJJIIJFHGIIHIIIDGIJJIJJJJIIJJJIJIGIIHHHHFFFFFFEDACEDDCCDDBBD?B>AADDDDCED
@5FW
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCN
+
@@<DDDDBHHGHFIIIEFGBHIIIIIIIIIIG?DHGIIIIGGHIIIIIIIIIIHEDDDDDDDDCCDCDCDDBDD>BDDCDDDDDDDDDBCC:@B@ACDDC#
@5FX
CTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTC
+
CCCFFFDFFFHHHIIIJJGGIJEFEHGIJFJIIJIJJJJIJJJJJJIJGHJJJIHGHEHGFFF@BECEDEECBDDDDDDDDCDDDDDDBD?@BBD>AAC
@5FY
CTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTN
+
@@@D;A@@FA?F?A8?CE@GE<CDF>DE>9?9<B;FHD:BBG<BH9@@FADH5;?=;A@;;@DC66;3,53?5@CCCC?:<>@>B99?<?<38?:CC9AC#
@5FZ
CTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATN
+
@C@FDFFDDFHHHIFGGIHGGIIIGHHHIJJEHIIGIJHIJJDFGIJJIFIJJBFGIIJJIGJ=DDGIIJHEEBFDEEEDEEDEEDDDCCDCDEDDDDCD#
@5G0
TTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTN
+
CCCFFFFFHHHHHIIJIIHJIIJIJJJJJIJIJJJJJJJIJIJJJJHIIJJJJJJJIJJJJJIJJJJJJJIJJJJJIJJJJJJIJHHHHHFFFFFFEFEE#
@5G1
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
@<;DDBDDFHB<DCABEEFAH?HHIIIGI@GIGHED@;F>?B@BHFGGEGF@CGGH=@AHEH;??D?CCC@>CAC@BB3==5@C>>ACBBBBBACCCACC#
@5G2
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
CCCFFFDEHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJFHIHHHHHHFFFFFFFEEEEEEDDDDDDDDCDDB#
@5G3
GCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGN
+
CCCFFFFFHHHHHJJJJJJFHIIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJJJJIJJJIJJIIJJHHFFFFFECEEEEDDDDDDDCCDEFEDDD#
@5G4
GCTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATC
+
CCCFFFFDHHHHHJJJJJJIIJJIJJJJJJJJJJJJJJJJIIJJJJJJIJJJHIIJIHHHHHFFFFFEEEEEEDDDDDDDDDDDD9ACDEDDDDDDDD
@5G5
GGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGT
+
@@@DDF=?FHAHHG@GBEAHIICHHGIGDDGGIGGGIDD?DEACHIBBGGGGEGH@@C@DHIGHFB==AHF@DDBCCCCCCC@B;CBD(
@5G6
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
CCCFFFDFHGHHHIJIJJJJIJJJJJIIJJIJIGHIJJJJJJJJIJJJJJIJJJJJJJJIJIIIIJJGEHHHHFFAEEFEEEDDDDDDDDCD?:>B@CBD#
@5G7
CTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTN
+
@@@7DDDDHHDFDH@FGECG?CECAGF>BEEE?FGEFHHII@GI<?@DDEGGB@BFG;BFGIIII76@DHHHEHHHEEEBB>6@CCC@==1-;@5;5@/9#
@5G8
CTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGN
+
CCCFFFFFHHHHHJJJIIJJJJJJJJJJJJHIJJJJJJIJIIIJIJJJJJJJJJJJJJJJJJJJJJIJJJIIIGIIIJJJJJJJHHHHHFFFFFFEEDCE#
@5G9
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJJJIJIJJJJJJJJJIJJJJJJ@EFDCEEEEDDACDDDDDDDDDDDDDDDDDDDDDDD#
@5GA
CCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTN
+
CCCFFFFFHHHHHJJJJJJJJIJIJFIIJIJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFDDDEDDDDDDDDDDDDDDDDDEEFDDDDD#
@5GB
GGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGN
+
C@@FFFFFAFFHHIIIJJJJIEGEHEEHHGJJIJIIJIFHHIIJIJIIJJJHHIJJJIJJJJJJJIFJ=BE=CEEFFFFFEEDDEDEDDCCDDDDDDDBD#
@5GC
CTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGA
+
@@CFFFFFHHHHHJJJJIGIJIJJIGGJGIIGHJJJJJIIIJJIJIIIEGGIHAGHHIGHIIJH@EHIHHEEEHHFFEDFFB@E@CEECDDCDD<@BDD
@5GD
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATN
+
CCCFFFFFHHHHHJIJIJJJJJIJIJJJJJJJJJJJJJIJJIIJJJJJFGIBGHIJHHHFFFDEEEDECDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCD#
@5GE
ATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGCTTCTGATC
+
@@@?DBDDHFCBHEGFHDGHIGDHHIGEHICFHIIBFHGGI8?GDGBHGIGHII==.@EEFCBB8@@>A?B9@@<?@CADECCBCCC(:?<<A?ACACA
@5GF
GTCGGAATGAAATCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
???DDDDDDDD+2AEE>ADCA+<1<1?4CCDDD<B4:DD<B><D<BA<9B<*98=)=3@7=A@DC6@CD<CA=3;)7?@@@?/;;;=33:>>>>A<<(29#
@5GG
GGGCATAGTTCAGGCCTTCAGGCTTGCCAGAAGGGCAGTAAGCCACTTGTTTTTCTTGGCAGAAATCTTTGTCTGCATGTGGTTCCTTCTCTTCTTTCCTN
+
@@@DD?D?F?<?D:;EAG3CEFF@E@EEHFFEFB@1CFB<FBDF@FFFF98BAFFFECFIFE?9CDFFC@;AE@@<3@DDAA@=BBBABA>ABB@BA>::#
@5GH
CACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGN
+
CCCFFFFFHHHHHIJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJHHHFFFFFDEEEDD@BDBDDDDDDDDDDDDDDDDDDDDDD#
@5GI
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
CCCFFFFFHHHHHIJJJJJJGGGIJJIJIJJJIJJJJGJJJJIIJJJIJJJJJHHHHHFFDDDDCDDDDDDDDDDDDDDDDDCDDDD@CBDDBCCDDDDD#
@5GJ
GCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGN
+
CCCFFFFFHHGGHJJJJJJJJJIIJJGHJJJJJJJJJJJJJJJJJJIJIJJJJJJJHHHHHHFFFDDDDBDDDBDDDDDDDDDDDDDDDDDDDDDEEEDD#
@5GK
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFFHHGHJJJJJIGEHHIJJHGIJJGEHIJIGGHJJIJIGGFIJJJIIIJBFGBHHAEHHFFFEFFEEEEE;?BBCDDEEDDDDDDDBDCDDD
@5GL
ATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTN
+
@CCFFFFFGDHHHJIJJJIIEHIJJJJGIJJJIIJJIIJJJIGHIIIJICHJJJJJIHEEEEFFDFFDD9>B?CDDDDDDDDBDDDDDDCDDDDDDDDD>#
@5GM
GTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHHHHHJIIIIGIJJJJIJJHIJJJJJJJHIJHIJIJJGHIJJJBFDEEEEDDDDDDDDDDDBBDDDDDDEDDDDDDDDDDDDEDDDDDCD
@5GN
GGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTN
+
CCCFFFFFFHHHHJJJJJJJHJJJJIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIIHIIFHIJJHFDDEEEDDDDDDDDDDDBDDDDDDDDDDDDDD:#
@5GO
CTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJIIJJJJIJJJJJJJJJJJJJJJJFHJJJJJJJIJJJJJJJJJJJIJJJJJJJJJHGHHFFFFFFEEEEEEEDD#
@5GP
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCA
+
?@?1=:DDDHF<;?:3:?:ABEE>9?F9AFG80CDE@?<4@*09B4099?BF7C=3@8@A7@3?EE97??;?@>>3;>5>C=2'(,5,>::((4(+(+4
@5GQ
TTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCTTCTTCTGTCTCTCCTCGTCCTCCATGGCCTCTGCAAGGAAGGCAGGGGAAAACN
+
@@CFFFFFDFFFBGIGIIGIIGIIIIJIIIIIIJJIJIIEGIIJCGHIIIIIGGGGGEGGFFHFFDEBCEEDDDBCCDDDCCACB?CAB@BDBDDBDDD>#
@5GR
CAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGN
+
@BBFFFFFHHGHHIJJJJJJJJJJJJIJJIIIJIJJJJJGIJJJIJJJJGIGGIJIHJJJIJJHIIIHIGHEIHIIJJIHHHGHGFFFFFDCEEEDEDDD#
@5GS
GGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGN
+
CCCFFFFFHHHHHJJJJJJIJJJIJJJJJJJIJJJIJJGIJJJJGIJJJJJJJJHFFFFEEEEDEDDDDDDBDDDDDDDDDDDDDDDCDDDDDEEDDDDD#
@5GT
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCN
+
CCCFFFFFGHHHHJJJJJJJJJIJJJJJJJJJJJIJJJIJJJJJIJHIJJJJIIJIHHHHHGFFFFD>CEEEDDDDDDDDDDDDDDDDDDDDCDDDDCDD#
@5GU
TGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGN
+
CCCFFFFFGHHHHJIJJJJJJJJJJJIJJJJJJJJJJIJJJHIJGGIJIJIIIIJJJJJJJJJIJJJJJJJIJJJJJJIJJJJHIJHHHHHHFFFFFFEE#
@5GV
GCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJHHJIJJJJJJJJHHHJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJJHHHHHFFFFFEEEEEEDDDDDD
@5GW
CATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACN
+
CCCFFDFFHDHHGJIHIIHHIJHIFGIJJFIGJIIIJJFGGIJIJIIIJJIGGIGFHGHGFFFFFEDCEDEEEDDCD>@CDDDDDDDDC@CFDDDDDDDD#
@5GX
CCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTN
+
@@@BDDDDHFHFH:CEHI9FC<IGEEIE+CFECEFGEFGBHIIGEHIIGGIGGIHGGIGHE?FAEEF=FFH8CHGIII>GEGGDHHHHECH;@C?@>;;A#
@5GY
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@@@DD?DDD8FH>DEEHEHGGGAGG@HBFHGEH>FE3:?FBGGGFGBFFFCA8DH@FHGGHEEG'59<>AC>@>>;>?A?7:??9?@>>ABAC>4>3>9>#
@5GZ
GGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTN
+
CCCFDFFFHHHHHJJJJIHGIGEHIHGEFHIIJIIJIGIJGIJJIJJIJJJJHGIIIIJGI@EFHIFDHHC@AEHED5;AECDBDDBCDDDEACDEEDDD#
@5H0
AGCATCAGGCGGTACATCTCCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATN
+
CCCFFFFFHHHGFIJJJJFIIHIIGJIIJJJIIJJIIIIIJJJJIJJIIGJ=B8?BFDDDBDDEDCACB>>CCD>CBCBBBDDDDCC?@?BCCCDDDDDD#
@5H1
CATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGN
+
?@@FDFFFHHGGHIGFHIHHIIIJIJGGGBHIHHIFIIJJJJIFIJGJIGJIIIIJJJIJHGGBFFEFHGGIIGIGIJIJJJJ@CEEAHFCDCDFCCCEE#
@5H2
GTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCN
+
CCCFFFFEHHDFHFHIJJJJJJJJJJJJHIJJJJIJJJJJJJJJJJJJJJJJIJIJJJJJIJIJHFDBDDDDDDDD>CCDDEEEDDDDCDDDDDDDDDDD#
@5H3
ATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTN
+
@BCFFFFFGHHHFIJIJJHIIJJIJJJJJJJJJJI?FGGHIJHIIJJJJIJJJJGIHHIIJIJJIIGD;@BDEDDCDDDADDDDDCADDDC@BBBDCDDC#
@5H4
GGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTN
+
BB@ADDFFHHHHHJEGIJJCFHIIJJIJJJJJJJJJIHIJJIJJJJJIJJJJJJJJJJIJJHHHHHHHFFFFFFEEEEFEEDEEDDDDDBDDDDDDDDDD#
@5H5
GCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJIJJHIJGIIIJJJIJJJHHHHHHFFDDADDCDCDDDDDCCDDDDD#
@5H6
GTGCGTGGACTGGGTGCTAGAATTCATGGTCGATTTCTCCCAGGAAGGCCTCAGGCAGAAGGTTAAGCAAAACAACTGCTTCTGATGATCAGGGCTTCC
+
CBCFFFFFHHHHHJHIJJHHJJJJJJJJJIIJJJJIJJJJJJJJJJJJJJJJJJJIJJJJJHHHHHFFFFFEEDDDDDDDDDDDEEDEEDEDDDDDDDD
@5H7
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
CCCFFFFFHHHHHJJJJJJJJJGHIJJJJJJJJJJJGIJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJHHHHHHFF@DDDCDDDDDEEDDDEED#
@5H8
CCGCGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@@@DDDDFFFHHDHIGGIGGIJJJGGEEHIIDG:@@FAFGCHGCGEGIGEEAAE@B<>ACDCCDDCDC,:ABDDBBDCCDCCCCDDDDDCCC@A<CDDC
@5H9
CCGTATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
@@CDDFFFHHHGGGIJIIIJIJIIIIJJJIIJJJFHJGIGDGGIJIIDHHGIJJGIDHHIJEHGDEHHFFFFFFEFDEEECBB;BBCC@CDC(>@@A:CC#
@5HA
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJGHIIJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFFEEEEEEDDDDDDDEEFEDDDDDDDDDDDDDDDDBDDD#
@5HB
GGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTN
+
@@@FFFFFHDHHFIIJJJJJEHGIGHIFGHIIJJJIJCFHHIIIIEGGIHJIIIHIIEIEGIJGJJIJJGIIJJHGFEHH@DFFFFEECEE;>;CCDCDC#
@5HC
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
@@@BD?DBFFBHHGBAFGI:?FGIHIIGGADFCHGBGDEEHCBHIBGGHEGGEGDCHC=FGII=;C=CCECEAD?@5?@>ACEEA=>=ACD>B(:>ACC
@5HD
CTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGN
+
CCCFFFFFGHGHHJJJJJJJJJJIJJJIIJJDHIIIJJIJIJJIIJJJJJJJJIJJHHHHFFFDDDEDDDDDDDDDCDBDDCCDEEECDDDDCDDDDDDB#
@5HE
CAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTN
+
CCCFFFFFGHHFFIIJJJJIGJJJJJIJHGIHJJJJJIJIJJJJIGHIIHJJIJJJJJJJIJJJJJGIHHIJGIGIJIIJEHHFEHFFEEFFEDEEDCCD#
@5HF
CGGCAAGGAGGAGGCATCCTCAGTCCCCATGATAAGGAGATTGCCTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTTN
+
@@<DDDDD?DHFD<EFAFCCDFFCCAGEEGGIIBHEGGH=@GEHIIIIIGEDHBGGG4@EA=EEE6?ACC@CCCCA>=AC?BBB5>>ABCCCCCCCCBCC#
@5HG
TTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTN
+
CCCFFFFFHGFHFHGIJJIJCEHGIIJJGIHIGEFDGEIHIBFDGHGGIHIIGGEHIJFHFHCFGI;CHD?BDFEEC;?CCCCDDDDDDBCBD?CCDD?5#
@5HH
GTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATN
+
@@<?B::B?DHBD<BGGDG?@FIII?FHE=@FHGGD00??@?=8.=FHD@@CGG;CE27)((?@@6>A@@@C@>C@C>@C:@><@5>:ACC<44@ADDDD#
@5HI
CTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATN
+
@@@FDFFFGHHGHJJJJJJJJGIGIJIIJJIJIIIJJGHHGIJIIGIGHIIIHIIJJJGHJJJIHHHHF?BEFFEEEEEEDDDDDCDCDDDDDDDDDDDD#
@5HJ
CTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGN
+
CCCFFFFFHHHHHIJIJGJJJGIJJJIIIJIIJIJGIJJJJJJJJJJIJJJIIJIIIGHIHIIJIJJHHHFFEFFFEEEEEEDCBCCDDDACDEDEDDDC#
@5HK
GGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACN
+
@@CFFFFFHGFHFGGHHIJJIJJIIIIIHFGIJIJJIJIJJJJJJIIIIIIJJIJJJBBHFFFFFFDEDCEEDCD@CCDCDDDDDDDDDD9@ADEDDDDD#
@5HL
GGCCTGGCCAGCGAGGAGCAGAGTCACCAGGATGGAAAAGCCTGTGTACAGGGCTCCGCGGCTGCACTTGCTCTCCGGGGCCCCAGGGCGCCGGCCCAGCN
+
@@BFFDFFHHHHHJJJHJJJJIJJJJJJIJJJJJJJJJJJJJJJJJHIJJJIJJJJHHFFDDDBDCCDDDDDDCDDDDDDBDDDDDDDBDBBBDDDDDDD#
@5HM
GTATGATGGAAAGGTTCAGAGCTCAGGGGAGGATATGGAGATCCAGGGAGGCTTCCTGTAGGAAGTGGCCTGTGTAGTGCTTCAAGGGCCAGGCTGCC
+
@@@DBDDDFHHHHGEDBAEIG>DEHGII<GDGGCDGHCHB99DDGGGG?HEA2CHGEC=EEECE>;CBEFCC6>CE@5?>>;@5>A(<?BB<2(8<8A
@5HN
CTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCN
+
@@@DADDAFFHGFIIJJJJJEIIJIHGEFGIIIIIEGJJJJJJJJJJIEGEIHHGIIIIJIJJI@HGEEFFFFFECEEDCCDDCDDCDDCDCCDCDDDDD#
@5HO
CCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCN
+
CCCFFFFFHHGHFIJJJIJJJJIIIJJJJJJJIJJIJJJIJJJJJJJJJJJIJJIJJIJJJJGIJIIJJJJJJIJJJJIIJIJJJIHHHHHHFFFFFFFE#
@5HP
GGCGTGTGCTGCTGGACATGACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGA
+
@@BFDFFFHHGHHIIJJJJJIJJJJJGHJJJJGFGIIIFDFFFADDDDDDDBDDDDDDCDDDDDDEDDDDEDDDCDDDACCC@CCDDCDDDDDDB@DBD
@5HQ
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
CCCFFFFFHHHHHJCGHIJJJIJJJJJJIJJJJIIGHIIJJJJJJJJHHHHHFFFFFEEFEEEEDDDDDDDDDDDDDDDDDDDDDDEEDCCDDDEEEEED#
@5HR
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
????=)0<AADDB??A?<A<<<1:)1:?BDD?DB<?D9B?*?B;B@CCEAD=@A=DIE3??>=;;9@8>35>A:,(58&+2>AAA:>:+>((4><.)9((#
@5HS
AAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCA
+
?@@ADDDBFHHFHIIIIIIIEEHBCHHIIIIIIIIIIIIIIIIFGGHIIIIGIIIIIIIIIIEGGHIGIGHGGEHAHIIIHGHEHFHFDC?;AA>;@>C
@5HT
GGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTN
+
CCCFFFFFHHHHHJIIJJJJJJJJJJJJJJIJJJJJIIJJIJJJJJJIJJJJIIJJJJJJJJJJHHHHFFFFFFFEEEDECDEDDCDDDACEEEEDDDDD#
@5HU
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
CCCFFFFFHHHHHJJJJIHIJGIJJJJJJJJJJJJJJIJJIJJJGIJIHIJHIJIJJJJHIEHIIIHHHFFFFFFEEEEECDBB?@DC@CDDDDDDDACD#
@5HV
GCCGTGCAGGAGGTCCTCGTGCCGCCTGTAGTCCCTGCGAGGATCCAGGCCCGACAGCTGGTGAGGCAGCCCCCGGTGCGTGTGCAGGAGCCCAGACTCCN
+
:1=AAD?B?F=FHHBHIIBIIIG6:C?F::0B<999B)??@@5=7)=7C9?;?4>83,(5((,,(9(5<<<89>5-0009+0)834+2(+<B88@1<>:A#
@5HW
GCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJHIIJJJJJJJJJJIIJHIJJJIJJJJJJIJJJJJJJHAHFBDBEFFEDEEEEEDCDDDDDDDDDDBDCDDDDCD#
@5HX
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGN
+
CCCFFFFFHHHHHJGHIGHIJJJJJIGHGJJJJJJJHIJJIGJJJIIJJJJJJJGIIIHEFDEEEDDDDDDCDDDDD>CD@CDDDDDDDDDD9@CDCCCC#
@5HY
GTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGN
+
CB@FFFFFHHGHHIJIFEBHHJFHIIIIJGJJBIHIIIIBFHGGEHHIIJGIHIIJGIIJIIJJGGHHHFACEF@DCDEDEEECCCDDCBD3?CDCCDBD#
@5HZ
GTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCN
+
?8=B?DB;DDA?DIII;CDEDEFEEDCECDE2@A8?DD<B>DEEICDEDE4B9?6;C>AA=@A?'9;>(>559>:A>>>AA?=>AA>>>59?>A:>>><>#
@5I0
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@C@FFFDFFFDBHGGHICHEBGGIGEGIIIGGFHGIIGIGIFEGGIIIIIGGGGGIGDE?HHHFFDA@B9>@A@(:?B@?@CCDCA@CCDCCAAAB<BD?#
@5I1
CTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTCTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTN
+
?=?D:DDDE<=+22<:<A33AFBAA:4<A?C9F?F??1111*8:1:00:BBDD<99DB?9?DDIIIEI<=8=/>@D;C=77)>.>=A==.=C77..?D;7#
@5I2
AGGGCTGTGTAGAGGAATAGCTGGTAGGAGGGAAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTN
+
?<?AADDDD<4+ACE;C:CBCFA;CECCC>C@8CDD;B@7?8BD9DCBCD)B>CA@C77@C=AC7@??A@6;=>A?;;>:AA???(83:>(:(4>A:>>>#
@5I3
GCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAATTGCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJIJJIJJJJJJJJJJJIJJIJHIGJJFIIJJJJJIJIGHHHHHFFFFFFEDE#
@5I4
CCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCT
+
@@CFFFFFHGHHHJJFEGHIJFIJIJJJJJJJJIIIIIJIIIJIIIIIFIJJJJJIGHIIIIIJGGGIIJJEEHIGIIHHHHHFFFFFCFCEEDED
@5I5
TCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCN
+
@@@DDD=DABFDHG9ED<ECD@DHCB9FGFEHGHCDGGIIHGGGIIE9B8BFEGHG)8BFFAFCCECBEDC>>5<BCCC98????BCB+:?38@>(4:AC#
@5I6
CACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTN
+
@==D?D?8ADAFFAAB?EHHHEH;E8DCFG;F9:BFHG?EA?BGGG<7@@FHGF@=C@DH=9?AD>BCACCCCCAAC@?C@B;@<93?>:4>>C>?9CB?#
@5I7
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@@<DDDDDHDHD>EE>EAEGGAHGGGCG9C@G@HFBB<FE@GHGCFHGGBEGDBDHHHEHHHDDEB/8@9@BC@:A@B98?@>C:>CCC<ACCBB<552<#
@5I8
CACTTCTCTTGCCCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGCGGCGCCCCCAGCCCCCTGAAGCCCAGAGATCGGAAGACGTCTGAACTCCAGTN
+
@@@DDFFFHHAFHJIFHGGGBHHGEGHIJJIIIBHGGGAGHB@AGIIIJFI8BBDAB85=BDDDDBCC:@?ABD?@CCCB9??9AC<2<CBD@@CCCDC>#
@5I9
CTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJGIIIGIJIIFGAFHHIJJJJJIJJJJJIJJJJIJHIJIIIIJJIJIJFHHHHGFFFFFFFEEDEEEEDCD#
@5IA
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@CCDDDFFFFFFDHFHHHGHIGIIIGEEGGIJGDDHEEHFHHGIGGHIEIGJEIGCCDA?ACADFF'5805?AC>ABBDBBCCCDAAACCCACBD>558<#
@5IB
TTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTN
+
CCCFFFFFGHHFGIJJIIHIHIJJJJJJJJJJJJIFDDBDDDDCCDDDDDDDDBCDCDDDEDEEECDDDDDCCDDDDDDDDDDCCDBBD>ADDDDDDDCD#
@5IC
TGTTAACAAATTGTACGAACACAAGACTTAAGAAATAAGAGCAGATGCTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTN
+
=;?BDDD?F?F?FC>C+<AFEADG@@FCCFFHB<C:DFGGHHGEDGH<BF8999=<@:F3=AD6=CCCH:7A9;?BDCE6>CAC@CAAC>>;;<@=892:#
@5ID
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJIIIHIJJJIJJJJGIIIJIJJJJJJJIIIIJJJIJJJIJJJJJIGGHGGHIICEFGHFFFF;>CD@CDD;>?BACDDDDD<AC
@5IE
TTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCN
+
@@<BDDFFHHFFBFEBFBFHGII@BHGIIGIGGIDHGIIIGGIIEEGIGCHC9BGE?8=CDBF==@EBAC?DDBE>?A?A==ABDDBDD?ACDDDDCCCC#
@5IF
GTCCGTAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHGHHGJJIHIIJJJJJIJIHIHIJGIJJJJJJJGHIJJJIJJJJJJJIJJJJJIJHIJHHHFFFEEEEEEDDDDDDDDD<CAD>CDD+>@D
@5IG
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CBBFFFFFHGHHHJJJJJJJJJJHIJJJJJJJIJJJJJJJJJIJJIJIJJJJIJJIJJJJJJIIJGGHHHHHFFFDFFFDDD3=BD;CDDEDDCDDDDDD#
@5IH
GTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGT
+
@B@FFDDEGGDDFHDGGIIIHIJIGJJIGIJIJIEIIGGIJGFHAAFHIEGJIHHGFGFFFFFEDEEECDCDDDDDDDDDBBDDD@>CC?CDC@@CDD.
@5II
GGAAGCAAAAGTTACCAACATTAAAAAAAATGTTTTTAAAGAACAAATACAAAGGTTCTATCCAACAAGAAAGAACATCCAGTTTTGTCTTCCCTTCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJHIHHHHHHFFFFFEEEEEDDDDDDDDDDDEDDDDDDDDDDDDD
@5IJ
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
CCCFFFFFHHFHHIJIJJJJJIJJ<EFHGIIIIHJJGHHIIJJJJIIIEGJJJIEEHFFDFEFCECCEEDDDDDDCEEEDDDDDDD@CDDDDBCDBACDC#
@5IK
GTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGN
+
@?@DFFFFHHHGHFIDIIJIJGGGGEEHHE?DDF>@C>AACDCEADDDDD@B::ACDDDDBBD:A>C<?B:A?CDACDBCDDDDACDDDDCD:@CCCBD@#
@5IL
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTN
+
@@@FFDFFHHHHFBHGHGGGEJGGIICFHGHCFHIJIEHEIGFGGGGIHIJIEGAF8BFGIIGICGH;D@CEE@>EHDFDEBCDB=ACAC@CDBBCCDCD#
@5IM
AGCAGAACAAACCAAAGAAAAAGGAGAAAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCN
+
=<<BDDDDHFHF@FHFH@EGHH>CHGCGEIAFHFGGGHE<FHGCHIIG;AG?GGDEEEHEB>=CCCCCBCC==BA:@C:CCBB?CAACCCCBBBBCCC>C#
@5IN
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
@@@FFFEFGHGGHJJDCFHJIJJDCGGGHJIJIGHHGGGIJGICHEHIJJGEFHJIGIIIHGIHHHFDD@C>AEECEDDCDC>CDECAACCCCCDCAACD#
@5IO
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJ;=D=CEDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDD#
@5IP
GTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTC
+
;?@DDD;:CFHF+<ECDGIF@FCCHCG<1991@9?FBDHH?F?BBFG<99?FEB/7;=B@8=@CHICEGE<B?BD;@CCC>@>>;;;599:::@ACCA>
@5IQ
GGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGN
+
8;?DDDDDFCFHFBDHI@CACAEAFH@FHCHHBG?EHHFG@9:B9D@FHIGDFGC:AG=;CF;@F;DGGH@>C;=?>?BDDB9>6@DCCCC>@=????BB#
@5IR
GTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACN
+
CCCFFFFFHHHHGJJJJJJJJJJJJJJJJHIJJHIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJIIJJJJJJHHHHHHFFFFFFFD#
@5IS
CTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGN
+
BBCFDEFFBHHG<EHIIJJJJJJEGIJJHIJJJJJJJJJJJJJJIFHIJIJJJJJJ@EIHHHHHFFDEEEEEDEDDEEDDDDDDDDDDDDDEEDDDDDDD#
@5IT
GGGGACAGCACCTCGGAGGGCGTTGAGGGAGGGAAGCGGAAGTGGCTACCACCCGACGGCACTGGCGGGGCACTCTGGGGCACTGCACCCCCCGCCAACCN
+
CCCFFFFFHGHHHJJJJJJJJJGIJJJJJHHJJIJJJHHFFD@CDDDDDDDDDDDDDDDDDDDDDDDDDD3583>43>CD9&83(:4:ABDD&&)9.529#
@5IU
TGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
?@@AD?B;CFBFHHIGH4IC>FFHF><@??DDA?GIE@GDGGIIG9CBCF=;.7@;C3@CC?AED;>;B>:;AC:;5-;3555;?@CAACAC,4ACDD
@5IV
TATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGN
+
BB@FFAFDGHHAFHIJIJJGIIJJIIIJJJJJJIJJJIJJJJHHIJJIFIGGIIJJJJIJIJJIJGHHHHHFFFDFFDEEEDDDDCCCDDC@CDDDCCDD#
@5IW
CTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGN
+
@CCDFFFFHHFDHII:EHHJIIJIIIJGGJJJIJIJJEGIIIEHGGHIIGIJJEFHFGIJJJJIJJHFDBDBDDDDCC49>:>CDEDDCB>ACDBDDDDB#
@5IX
TTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTCTN
+
@@CFFFAD>ADBFIIIIGBHIIIGHIIIIIIIFIIIICFEEHEHIIGGIIIGI;BFCGHH@DB<FGBDBG@GC;=.=CF>ECGEGHEHHEHD:@@>DC3>#
@5IY
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGN
+
CCCFFFFFHHHHHGHIJJJJJJJJJJJJJJJJJJJGIJJJJJGGDHHGJJJJJJJJJJJBHIJGIJH;CEFEFFFEED=BCDDCDDDDDCDDDDDDDDDD#
@5IZ
GTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTN
+
<@@DBDBDFFF?BC?EGBHB<3<F?:<FBBACAA9?FG@CGGBGICFD:B<<FBBBG?09BB@FI>.B=<B8787.8=FE7@E@@EEAEF>C>?DDDEBA#
@5J0
GCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTN
+
@CCFFFFFAFHGHIIII?<EGGHIIICC@FGGI@>BHGHGIBHIGHG@DHBEBG8=DDGGDEBDFFDCBBB;BD8>A@:4@CCCDD7<&)0?<CDDC@CD#
@5J1
CTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCAC
+
CCCFFFEFHHHHHJJIJIJJJJJJJJJJJIIIJJJIJIIJJJJJGFHHHJJJJJJJIJEIIGIIIIJJJHHFFFFFDEDEDD?B?BDDDDDCCCDDCCD
@5J2
AAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCN
+
@@@DDDDDFFHHHGEGFGIIIBGEDGGFHIIII:BDGGCFHIIIIIGGGIGIEHIIIGGIIGGGHFEFFFFFECDECCCDDDDDDDDDDDCCDCCDDCD@#
@5J3
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGN
+
CCCFFFDFFHHHHJJJIIJJGHIIJIIIGIJJJJJIIJIIJJIJJJJJJJJJIHIJJIJJJGGIGIIJGEEFFH=CCDDDFBDEEDDAACCDDDCBBDDC#
@5J4
CTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIIIIJJJJJJJJJJJJGIJIJJJJIJJJIJJIJJJJJHHHHFFDDEDDFDEDDDDCDDDDDDC
@5J5
GTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGN
+
CCCFFFFFHHHGHIJJCGIIIJJJIHIJJIJJIIJJJJJDHHJGIFHIJHIJGHJIIJJJJJIIDHHIHHHFHHBDCBCEFEE@C@BDCBDBDDEDDDDD#
@5J6
GGGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGN
+
BCCDDFEFHHHHHJJIIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJHHHHHFFFFDEEEEEEDDDDDDDD9ACEEDDDDDDDDDDCCDD#
@5J7
TGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGN
+
:@@DD2A4DAA?FA??G<?3@DGFDDG?C9C@EGDFB*CFFFFCEACDF:5@4@>@@E?CEF.;B?;?;6;>AA?;;-;;???9AAD@B>>>?>(::@:@#
@5J8
CCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTN
+
@@CDDDDDFHFDFG2@<CBCHHI@E@BGH9DGGCGGFFEGI99?F@FHGGHHEGIIIIC@GIGHHA9A;?BA9@:>;AC;9=B5<AA@DD@C>A@A:>>5#
@5J9
CTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGN
+
CCCFFFFFHHHFHJFHIJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJIJJIJIJHIHHIJHHHHHHHFFFFFEEEEDEDDDDDDDDDDDDDDDDD#
@5JA
GCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
B@@FDDFFHHHGHIJJJJJJJCFHIIJJJJJJGHJJJJJIJIIIJIJJHHIJJIIJIJJJIJIGIIIIJDHGHCEFFDEDDCCDBDEDDDDDDDDDDD
@5JB
GTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGN
+
@?@BDDDDDFHFHICG;EHGGHGEGFCHGGICGGIIG4@EFHEEE@BDDCCB@?C?B:=@B>CDCCC@C@>CCCCCD@CCCCCC>:>CCAACB7<<?C4@#
@5JC
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
@@@FFDDFDDH><EEHFGECHHIIIFH>A@FGGHIE0BFHFH@=@GHHGGCHEHEEEEFEBDCEACEEECCCCCCCDCCCCCCCCCCCADC::@>AC><<#
@5JD
GGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGN
+
CCCFFFFFHHHHHJIJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFFFFFEEEEEDDDD?BDEDDD#
@5JE
CCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATN
+
CCCFFFFFHHHHHJJJJJJIJJIIHJJJJJJJJJJJJIIJJJJJJJIJJJJJJJJJJJJJJFJHHIJJJJJJGIJJJJGIIGIJJHDHHHHBDFFFDFFE#
@5JF
ATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCN
+
CCCFFFFFHHHHGJJJJIJIIIIIIJJIJJCHIIIJIJJJHIJHGIJJJJIIJJJJJJIGIFIIHHHHFFFFFFDECDD?DDDAADDD@CCDDCDDB?BD#
@5JG
GGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
CCBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJGHIJJJJJJJIIIJJJJHHHHHFFFFFEEDDDDDDD<@D@BD9?CDDDC
@5JH
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTAT
+
CCCFFFFDDDDDDDDDD@CDDDDEECDDDDDDD@BDDDBBDDDEDDDDDDCCDDDEDDDDDD7BBDDDDCCCDDDDCDDDCDDACCDCCDDDDDDACC
@5JI
AGCGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGN
+
B@BFFFFFHHHHHIJJJJIJJJJJJJJGIJJJJIJJJJJJIJJIJGHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDBDCCCDD#
@5JJ
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
CCCFFFDDHHHHHIIJJJJJIIIGIIJIGFHIJJIJ?FGHHIGHIGIDHIJIJJJJIIEGHGIIII;AH:CHHFFFFFFFFFEECEDC@@BBDDDDDDD>#
@5JK
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
CCCFFFFFHHHHHIHHIJJJIEHIGGGGHEHIIJIJFIHGCHJJJ@AGHIGGHFEEEEDFAACDDCCDCDDDCCBCDCC@CBDDCDDDCCABDDCCDDCD#
@5JL
TTCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGN
+
<@@FFFBDAFHHFGHIGIEFHG>CCGHHIHIGHIIIGDDEGGIIEIIGIDGEGHGIFIGEHHE>DB@DFCEEECCDDCADDAAACCCCCCCCDDDB@@@D#
@5JM
GGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTGGGGGGGTCCATCCGGCCTCC
+
@@@A:;+A::AF;BEBFD@HHAF<ABGFIIIIEE>9?;DDFFD>F>FD9?@<4BF0@;FDCGIIA@??E<1?@>6(;A:>@'29-&08>BB?B>9@<18
@5JN
GTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGAGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTTGCCCTGCTN
+
@@@<D?DDFDDD?ACG<CC<ACHE3?BEHE@@@91:EFGE**1??B)8@/?D)98C8=FGHGGA@;3.=;A1)5AD2=@'8,,3:4((+9A(:3:::?@C#
@5JO
GTGTTTTCATAGTCTGTAGTTCTAACTGGTGTATTTTCTGAAGTTCCTTGATCTTTTCCTCTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCN
+
BBBFFFFFHHHHHIJJHJJIJJJJJJJJJHIIIJJJJJJJJJJIIJJJJJJJJJJJIIJJJJJIIJJJJJJJJIJJJJJJJJJJHHHHHHFFFFFEEEEE#
@5JP
GTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCN
+
CBCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJIJJJJJIJJJJJIJJJIJJJJJJIIGIIJGGHGFFFFDACCEEFDDDDDDDDDDDDDDDDDDDD#
@5JQ
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
@@@FFFFDHDHFHJGJIJGIJJIJJJJ>FGHBECGI6?FDEGHGBFH';FDEHIJFFFEHH@?BED>A@BACCCCCCCCCCDDBCDCCDADACDDDDC
@5JR
CTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJIJJJJHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDEDDDDD#
@5JS
CCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTN
+
@<?=?B?BDFHF?HGHBG@FEHGBG<GHIA<DEDFHGBGGAA?DHGIBFGGAA;C;=@=ACECHEBDED@;>CCACCBBBBBB<B<>A@@CC?BBBB?A+#
@5JT
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTN
+
@=?=DDB?FHH?BGFG:??GBBGB98CF=@CB@;FHIG>9:?@FA?FF??BFGG==@FD>@)7@7=C=7).??C;776>66.>@3>>?BC<?B5;<9?@)#
@5JU
AGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTN
+
@@@BAB?DFFFHHIIIIIIIEEGIHGGEHEGGGFFG@DGHGGIGIIIHHFFFFDDFEEDC??6=?BDDD>C@DDDDB9?(4<4(:>:>ACC@AACDD@CC#
@5JV
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
CCCFFFFFHHHGCDHIGGHGJIGHHJIJJJJJJJJJIIJJJJJJDIIIIJIGGGGGJJJJJ=?ACECDDCCDDDDDDDDDDDDCD@CDDDDBDDDDDDDD#
@5JW
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCN
+
CCCFFFFFHHGHHJJJGGHIJJJIJJJJJJJJGIJJIJJJJJJJJJJJJJJJJHFDDDDDDDDDDDDEDDDDDDBBBDDDDDDDDDDDDCD>CD@CDDDD#
@5JX
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCN
+
@@@DDBBDDHDHDFFEFGEFHBHGDAHIEEEHIGIIGIGHIIIGIGIIGGHGGFHGE=CFHI=@AG=ECEFFFFDDECEBDADCCA@CBDB@DDACCCAB#
@5JY
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
@@@DDDDDDHBFHIAGCHF@9B?2CBEFDA?FEIEGII9?DHIIIIGC>D=F?BHIGECHIE7=@@EGI>89><@>CCADCC>C<?<?<?A<?ACABBCC#
@5JZ
GTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGN
+
CCCFFFFFCFHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHH?EHFFFDFDDDDDDDDDEEDDDD?BD#
@5K0
CCCAAATTAATCTGATTTGTGGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGTTTTGATTTTCAAGCACTGCCACTCTGTTTTCTN
+
CC@FFFFFHHHHHEIIGGDCFHIJJAHFGGGACFDGGHI9?DFHID?;BGEHHIIJJIJIBHFGEGEFFHGGDCDGEEAA>>=ACFCFCE;ACE>ACDC@#
@5K1
TCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJHHHHFFDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@5K2
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
CCCFFFFFHHHHHJJIJJJJJJJJIJJJJJJJJJJJJIJJIHGIJJJJJJJJJJJJJJJJIJJJJJJHFHHFFFFDD;ADBDD;BCDDDCDDDDDCCD:?#
@5K3
CGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGN
+
@C@FFFFFHHHHHJJJJIIJIJJJJJJIIJJIJIJJJJJJJIJIJJJIJIJJJJJJJJJJJIJJIHHFFFFFEEEEEEDDEDDDDDDDDACDDECDDDDD#
@5K4
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGN
+
B@BFFFFFHFHHHJJJJJJIIJJJGIGIIJIIIGIGHIIJJIGHICHIJIIGIJJIJ=DHHHHGHFFFFFFDCECDDDDBDDDEDDDCDCDEDDDCDDDD#
@5K5
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJIJJJJJJJJJFHIJJJJJJJJJJJJJJHHHHHHFFFDDDACDEDEDDDDDDDDDD#
@5K6
CCAGTTAATAACATCCCATTTCTCATCTGACAAAGGGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTAATTTGATATACACCTTTAGGTCCTTN
+
==;;=D:=AD<3DE3AEEDE>F<<E<CFF>ED>EC)1:C=DEEDDI><9BDD388?BD38=C)8)==)=A>)))).==;>>C=3)?;A3;6>A;6>A5>>#
@5K7
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCN
+
CBCFFFFFHHHHGJJJIIJJJJJJJJJJJIIIIIJJJJJIIJJGIJJIJJIJJIICEHHEHFFFFDFEACEEDDDDCCCDEDCDDDCDDDD>CDDBDDBD#
@5K8
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATN
+
<@@DFFFFHHHHGICGGGGHGJHIIIIJJJGIIHIIIJGHIJJJJIEGGIIJIIJ@BHIHHHHFFFBEFEEEEDDBBDDCDCCDDEDEDDDDBCDDDCCC#
@5K9
CTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCN
+
@@?DDDBD?FHBHCGHDCFDHIBFGIIIIIIFHFHIIGDGGEDHGHGGGIIFGCHIBDGICHHCGIIIGIHFHFEHHHCDDEFFFDCECECECCCCCCAC#
@5KA
CTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTN
+
CC@FFFDFHFGGHIAGIIJIIIJIIIIIJJEGHGIEHJIJJJJJJIJGIJJJIIIIIIJJJJJJJGHHIJJHIIGIIJHHHHHGEDFFFDFEEEEEEDDD#
@5KB
ATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGCTGAAATTGAATCTGTAATTN
+
CCCFFFFFFHHHHJJJIGHHHIJJJJJJIJJIJJIJJJJJJIJJEIGHIJIJIJEIJJGIIGIJIHGIJIJJGIEHIJJJHHHHHHFFFFFFCCEEEEDE#
@5KC
CATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTN
+
@<;DDDDD<D?CFGBGAAHHHH4CFHGEB9D<?:10BDCG8DBDD>>CHGI<FAAA.7@EHHEA;;?B@>AA?@39=ACCCBC>?:@CCCC?<@@BCCCC#
@5KD
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJHIJJJJJJJHIIJJIJJJJJJJJIJJJJJJJJJJIJJIJJJJIGHHHHFFFFEEDDCCCDDDDDEDECCDDDCDDDDDDD
@5KE
GTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCN
+
C@@FDFFFGHHHHJIJGIJIIIIIJIJGGCEHHIIHIFHGJJJJCHIIJJIHEHGIGGHIJJ7=DEFH=AE@DFDFDDEEDDDFDDDDCBDDDDEDBCD?#
@5KF
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTA
+
B@@F=BDAFFHFFIIJIIJJGIJJJJIJJIIJIJIGGHEHIIIIIIIHFHIJJJJJAHHHGGHFFFDFEEEEDE>BB@CDCDDDAC;CDDDDD09@D9>
@5KG
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCN
+
@?@AADDDHDB?:AEBF8<CHEGIIGI@EDFC?EFF@DEHIIIIEHID@AAADGDGIEF>;@CCADHEFEB;;><>ACCC:34+:(:>@C:2:@?8?B<?#
@5KH
TGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
CCCFFDFFHHHHHJJJJJJJJJIHJIJJJJJJIHHJJJIJJJJJJJJJJHIJJJJJJJJJGJJJIIJJJHHHHHFFFFDCDDDDDDDEDDDDDDDCCDD
@5KI
CCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGC
+
CCCFFDEEH@DFAGIIJIGEHFEFHIEHGIIGIIJJJIIIHFGHGGIJJJIJGIGGHGIGDHGHGGGHGIEIGGGFEHACEFFBEECCCEEDDCCDCAC
@5KJ
ACCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACN
+
BCCFFFFFHHHHHJJIIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIGIHJJJJJJJJJJJJJJJIJGIJJJJJJHHHHFFFFDDEDEDDDDBD#
@5KK
CGTATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCN
+
CCCFFDFFHHFHHJJJIJJJIJJJJJJJJJJJJJJIJIIIIIJIJJIGIJIJJJJIIJJJIJJJJHHGFFFFFFFEEEEEDD@B@CDACDD:@CDD@CCB#
@5KL
CACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCC
+
@@@?DADFHDADBEHHEGEHIGEII@D@CDBECEGHGAHHC?FGC@F@;=CHHEHDE97>E;3@DFACC@CC>AC?A=5<<ACCCCCC>@@>>CDA>C
@5KM
TGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTN
+
@@@FD?DDHHFFDCFEBFFII@CEIFHIIJJG@F@GEFFHDGGFCEGHH>;AAFGDHG7=AEEHHHFFFFECCDCEDB?>B@CCDCCCCDDDD;@@CCCD#
@5KN
CTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJIJJJJJIIJJIJJJJJJJJJJJJJJJJIJJJJJIJJHHHHHDDFFFFFFCEDEEDDEDD;ACDDDEDDCDDDD
@5KO
CATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGN
+
CCCFFFFFGHHHHJJHIIIJJJJJJJHIGGJJIJJJFGFGIGIJJIIIJIIJJIJJIJIJJJJJJIJJJJHHHHHHFCEFFDEEDDDDDDDDDDDDDDDD#
@5KP
CCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGN
+
@@@FFFFFDFHGHIIJGIIJJJJJHHEHIBGIJGIJJJJJIIJIIIJJJJJGHIJGHHGEFFFFFEDEEDDCCCDDDDDDCDDDDDDDD5<BBDCDDCCB#
@5KQ
AATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCN
+
;;?DD>)0<@CD:)CE8E?EE?:1??91CDCECBD6990*?*7-7/46AD:;667?3..)6;(.>>6;82885988>8833>A>8:A:A>4>399>8988#
@5KR
GGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGG
+
CCCFFFFFHGHHHJJJJEHFHJIHIJJJJJIJJJJJJGIJJJIIIJHJJIIJJJJJJJJJJIJJJIJJIJJJIJHHHHHHFFFFBDEEEEEEDDDEDD
@5KS
CCCCACTTTGCGGCTCTCGCGGAGGAAGCCCCGCAGGGAGCCGTATTTGGCGTACTCCACGATGAGGAGGAGCGGGCCATCCTGGCTGCAGGCCCCATACN
+
=?<=:?DDF<B88:@@C@FF6@DFF;;==8=A;AEB'',,3;;8;9B@BAB@B<52>9A<2;BB@>3@<0888009@BBBBB::?8<08>9258<@?9>?#
@5KT
CTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
@C@FDFFFGGDDFGHIIIIJIJJJGBHGHJIIGHJJDHGIIEHIGGFAFBFFEGHEIGIHHGG@GGIGHGECFBBECECCCCDDDDDDDDDDADCCA>
@5KU
AGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTN
+
CCCFFFFFHHHHHJIJIJJIJJJJIHJJJJJJJJHHHHGHFFFFFFEEACEEDDDDDDDDDDDCDDDBDD8ACDDDDDDDDDDDDDDD@DDDDCDDDDD8#
@5KV
GTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTG
+
@@@DDDDDDDBFDE:FGGDF:D;DAHGIFHCG@C2;;FHHAG>ECCCE?CDBD;CCCA,;?@>ACC>;:5<CC>AC::<AB8?@28?0>@83:88<?4<
@5KW
CCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATN
+
@@@DD?DDHFACCFHIIGGHGIGIIIIGGEEHGGIGIIGFFGFHJIHIIIIHGGIIGIIJJJIJHHDFDDEEEED=ABD8??CCDDDDCCCDCBD09BDC#
@5KX
CCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
CCCFFFFFHHFHHJJJHJJJJJJJJJJJJJJJJJJJHJJJJJJJIJGIIIJJJJJJJJJJJJHIJJJJJIGIIJJIJJIIHEHHDEFFFEDEEEEFECE
@5KY
GCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTN
+
@@@DDDDDHHF?AF?FG>GCBG?FFEC??DHEHDHGGIIGG;@5<B9BBBBB7@BBBB7<?CDECECCBB>9>BBBB0<@<?CCC>A@C@4@CDCABBB9#
@5KZ
TCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTN
+
CCCFFFFFHGHHHJJJJJIJJJJJIJJJJJIJJJIJHIIGGIDHIJIIJJIJJJGHIJGIJJJJJJJJJJJIJIIHHHHHHFFFFFEEEEEDDCDDDDDD#
@5L0
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCN
+
CCCFFFFFHGHGGJIIJJJIFHIJJJGGHIIIIGIJJDFHGIGHJJJIHHIIJIHHGGFFFFFDEDECDCDDCCDCDC@DDCCDDCCDEDDCDDDDDACC#
@5L1
GGCCGCTTAACTATCAAACGTGTCCATTAATTTTGCCGCTGAGGGTGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGGAAACCCAGTGN
+
CCCFFFFFHHHHHJJJJJJJJIIIJJJJJJJJJJJJJJJJJJJJJBFHIJJIIJIJIJHGHHHHHHFFFFFFFECEEEEEDCDEDDFEDDDDDDDDDDAC#
@5L2
GTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTN
+
@@@FFDDDHFHGHHHF@HIEHICHHGHGIGGEGH:CDGGHGIIGIGICHBFHFHHGEDGIJIJJ@GA@GGGIIHHFE?EEFCDC@C>CEEDDDD,;@@CA#
@5L3
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
BBCFDDDFHHHHHIJHIJJJJJJJIJJJJJJJJJJJJJJJJJJJIIJJJJIJJJJJJJJJJHHHDCD@CDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDD#
@5L4
TGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGTCGGCN
+
@@BFFFDDHFHFHIGIJJJJJIJJJGIHIJJJJJDGEHIIGHIJIJIJJIJJIEHEFFDCCCEEECDDDAAABBDDDCADDDCDDBDDDDDDDCA>A<B>#
@5L5
CTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
@@@FFDFDFHFHHJIJIJIGIIGEGBHHIJGIBCHJIEDFGGGGIIICHGIGGGHGIHFHGGGG>GE?CEH?CEE@C@CAECDD9;BB9CCDEDDACBB
@5L6
CTGCTGGCAAACCTCAGAGGCCAGGGGCCCTAGAGGATCAAGTTTCAAAGGGGTTGCAGGAGACAGGCCCTGAGACCCATTCATCAGCTGTGTGTTCTG
+
?81=;BDDADD>DE>>:C<;@E;C9C80?@D?;9<DD9D@<@8=<B>=.BDII;AA>C;>?(6;>@@??>(5<?AA?5<A>BDAAAA<4:(++2<>:A>
@5L7
CTCCCTGTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTACACACAGGTCTACAAGGTCAACCAAGGTGAGTAAAGGACCATA
+
@CCFFFFDHHGHFHHIJJJJJJIIHGIGHHH:EGIHGIJIIIIJJJGIJJJIIIGHIJHJJJJJ@HGIJIJIFEFHHHFFFFD;ACEACDDDCDBDDCD
@5L8
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
CC@FFFABFHAFHGGGGHIIIEGGCEGHBEHEEGDFHGIIIIIIFIIDFBGIIIEHGIIIGGGIIIEHHH@BDEBECECE@CDDDDD;BDBBCDDEAC:A#
@5L9
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJGIJJJJJJJJIJHHHHHFFFEEFFDDD;@DD@CDDEDDCCDDDDD#
@5LA
CCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGN
+
CCCFFFFFHHHHGJJJJJIJJIJIIJJJJJJJJJJJJIJFGIJJJJJDBBDDDDDDDDDDDDD<@BDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBB#
@5LB
GGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
CCCFFFFFHHHGHIJIJJJJJJJJJJIJJJJJJIJJJJIJFGHIJJJIJEHGEIIJIIJGGGGIIGIGG@HIHHCECDEFF>AEECEEDDCDDCDCC
@5LC
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
@@@FDF?DFAHBAHBHEG@IG<FFEGH@GHBHGGECCFHGHIIIEHIGIIIHEHHIIICDH@GIIG=FG8C>EHACDFDFDEEEEAE6@?BBCBBCCCB5#
@5LD
GCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGN
+
@<@DDDDDFHHHFI>H@EHDHGDEB???EGGIIC????GDHEGIB;F4@B8=D=>A<@BB99?:8<?ACC@?BBB50+58<?<CDD>@:::>>?B<<<<8#
@5LE
AGGGCCCAGGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGN
+
@BCFFFFFGHHHHJEHGIJIJJJJIJJJIJJJJIJJJIJJJJ?GHIJIJJHIJJJJJJJIJHHIJIIJFEDFCEEDDDDDDCCCECDDDDD@@BDAB@CC#
@5LF
CGTGGCTGGGCGCAGTGGCTCATGACTGTAATCCCAACACTCTGGGTGGCTGAGGCGGGAGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCA
+
@@?DDDFFHHHFGJGJIIIIHIIGIIIGFGIIJIJJJJJJIJIIJJ;AGHGIHHFFED?77<89929?:3>38+9>3?42+9:?A<?<@321?38<9>>
@5LG
CAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGTACATCTCCTCGCTGCAGTTGTCTGGCN
+
??8A:A:A?CFDBCAA<EE?GHIICBEHEID@@BGEB?BD1@FHIEDHGEC??EHHECBB@>>C;;>@CC=>;39BCA:@C@CC@9B<53ACC>::4+34#
@5LH
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
===DAD+=<DBAC?:<<E<<<333C9CF<9CBECECC??D?DDCDB99BD<BDD@B8==CDIA5549,;>@A>A5>?>;5=<???AA488A39A::((+4#
@5LI
TTCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
CCCFFFFFHHHHHJJJIIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJGIJJJJJIJJJHHHHF9AB;CDDDCDDDDDDDDDDDDDDDDDDDDDDDDDD#
@5LJ
CTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIHHHFFFDEEEDDDDCDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDD#
@5LK
GCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCN
+
CCCFFFFFHHHHHJJHIJIIIIGIHJJJJJJJJJJJIIJGIJJIJIJJEHHHFFFFFEDCFEEEDDDDDD3;@BDDDDDDDDDDDDDEED@CCDDEEDEE#
@5LL
GGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTN
+
@@@DFDFFHHGDFBGEEH@DAHGHFHIIB?CDGGIEHHGI?FFGIIBDHIEBGGFFHIGGH;FEHIFEDB@CCC@CDDDDD?BB@DBBCCDDDBBBCCC>#
@5LM
CCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACC
+
@@CDFDFAHDFFBHGGGGEFHGHGHFCEGGHGGD@BGD;:BDEEGFCH>DBEFDBHGGGHJ@BH:ABEBCEDE>B@CCD>>A-;??>CCDDCCDDCCD
@5LN
CATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTN
+
CCCFFFFFHHHHFIJJJJJIIJJJJJJJJJJJJHJJJJJJJJJJJGHHHHHHFFFFFFEEEEEDDDDDDDDDDDDDDDDDDDDDEED>CDDDEDEEEDDD#
@5LO
TTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGN
+
CCCFFFFFHHHFHJJJJJJJIJJJIJIJDHEHGHIJIJJJJJJGJJAHIIJJJJJJJJJJJJJJGGIGIIEHFDDDDDDDDDDDDDDDACDDDCDCC?AA#
@5LP
GTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATC
+
@B@FFFFBFHHHHJJJJJJHIJJIJJJJJIIJJIJJJJJJIIJJJIJJJIJJHIIJIJHGHHFF@DFFCEACECCDDDDDDDDDD?CCEEDDDDDDDD
@5LQ
GTCGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTN
+
@?@FFFFFHHHHFHIIGJIHIBFGHGHGHBGHGHIHIIJJJEHCH@FHGHE@GDHHHGHIGICFFHIEHIGH.;CFB??CC>CDDACDD>CCDCCCD:AD#
@5LR
CCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACN
+
@@@DDFFFHHHFFGDHEF<FGGEEGE?DCGGCHGHGEHAGHEIIIHIIIJJCF>@HGHGGAEHHGGHCDD:@DDDDDCDDCCC>CCCCCCDACD?>>A:A#
@5LS
TAAAAACTTCTGAAGACAGATGTGCTATTAATACTAAAACAATCTTTTTTAACCATGTGCAGCAAAGTAGGACCTTCCAGAAAGCCTATTATTCTGTAT
+
CCCFFFFFHHHHHJJJIJJJIJHJJJJJJJJJIIJIJJJJJJJJJJJJJJGJJHIJIGGGCHIJIJJHIGGIJHHHHFFFFFECEEEEDDCDDDFED@C
@5LT
ATCCATCAAACTTTCTGGAGCCATCCACCGAACTGGGAGCAGGCCTTCCCCTCTCTTTCTATAGTAATCATTTTTATAGATGTCTCTGGCGAGTCCAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJIIJJJJJIFHGHHIIJJJJJJJJJJJHHHEEHHHFFFFFFDEEDEEEEDDDCCAC@DD@CDDD
@5LU
GTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCC
+
@@CFFFFFDDDFDEGHIJIJEGIJGIIGJIJHIIEHGGGGGGGIIJGHGGIJGHFGIJEFEHECEHIIHGGGIJGGHHHHGHFDFFFCEECACCDDCDD
@5LV
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
BC@FDFFFHGHHHJJGIJGHHIIJIJJJJJJIJJJJJJJJIJJJJJJJJJGIIJIJHJGIIIJJJJGIJGHHHFFFFFEEEEEECDCDDDDCB,:CCDA
@5LW
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTN
+
@@@FDDFBFHH8CEGFHIIIII?FHIIGHIIIIIIIIIIIIIIIIFIEIIIIGHHHHGEFFFFFDCECCCDCACDECCCDDDACDDDDBACCDDDDD:@A#
@5LX
GTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTN
+
CCCFFFFFHHHHHJIJJJJIJJJGHIJJJJJJJJJJIJIJJJJJJEIJJIIJJJJJJIIJJIJIIIIGHHFFFFFEEFEEEEDDDBDDDDCDDDACCDDC#
@5LY
CGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGAGTGTCCTCCCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCG
+
<?<D?ADDFF<FA?<,AF@3<CE7F?EG@EDDF:FBB9;?:D@3BC)8.@F4)==CC@;=A;?;?@B>>AA@8?=>=::>;>AAAABA(:4:8>3>>4)
@5LZ
AGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCAT
+
:;@DDDDDD;AAFAGBEEFEG?@??EDEGH<:DB@FH@DD>AA@AB47<BCCC3>BCCC@CCC>BBB?790;>@:@CCCC<?@CA>:ABB?>09@5?((
@5M0
CGGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTN
+
@CCFFFFFHHHHHJJIJIJJJIHJIJIJJJJJJJFHHIJJJJJJJIJJJJHHHHHFFFDDDDDDDDDDDDDDDEED@CDDDEDEDEDDBDDDDDDDDDDE#
@5M1
CTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTN
+
CCCFFFFFHHHHHJJJJJIIIIJJJJJJJJJJJJJJJJIJJJIJJIJJFFIJJHDDDEDDDDDDDDDDDDDDDDDDDDDEEDDDDDDDDDDDDEDDDDD>#
@5M2
TCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATC
+
CCCFFFFFHHHHGIJJJJJJJJIHHIJIIJJJIJJJJJJJJJJJJJGIJIIIIJJHHIIIIJIJJJIJJJIGIIJJFGEHHHFDFFFFFECEDFFEDED
@5M3
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
@@@DBDD??D?A?FD)<2@CCFDF>HFC?EBGEFEBGFFDFFIEFIIIIIIFEIFFIEEEFCECB=;@3;ACCABBBBBB5>@A>>>?<97?@>ABA:A:#
@5M4
GCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATA
+
CCCFFFFFHHHHHIJJJJJJIIJJJJJJJJJJJJJJJJJJIIIIJDGIJJJJIGIJJJJJJJJJJJHHHHHHFFFBEFEEEEEEDDDDDDEDEDDDDE
@5M5
GGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTN
+
@@@BBBDFDF>FHIIGGGIIIIIGHHGFFHHGIIEGEDD?F?DEHBFGIIII<BDFGBFH<BFHBGGGIIHIIIFE3??EFBB.=/'5;=@@CDDCCCEC#
@5M6
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGA
+
??@F=BDDFFHFHEGGHHIHIGEHDDHGIGHGEFFHEGEFHICDHHIIGIGHCAGEB8B7@<C@C:C:9A@DDDEDCAB:ACB8?BBB?8@CCDDCCD
@5M7
GTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCN
+
@?@FDDFAFFHHHIGIHIGGIGH@HCDHHGHGEHFHAFHIGIIIIIIIIIIIIIIIHIGHHIGIIIFHGIGIIGIIGEAHEHFFCFFF;@C:@CC>CCDD#
@5M8
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCAT
+
?@@B??D?C;?:ABBGGB:<AC:CB@8FGF=?FF;B??900*?<00?6<@0)5+>>ABBBBB(:4:@:>+8+49<(2<0?<24444+4::4>4>B((:
@5M9
AAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCG
+
8=?DDDBDAHDDDGHGGGG;CGG=G?FAGHFBFC>GGID?B><BFHIGGBGHFAG;:AHHFEEED>CCCCCC;;>BBBBB<<C??>:>ACDCCC?BB
@5MA
CTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCCAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJIJJJJJJIIIHJJJJIGIJJJJJJHIJIIJJJJIGIJJHHHHGHFFFFFCCDEEEDDDDDD>AC>#
@5MB
CCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTGTCTGACAAGAAAAGCTAAAGAGAGTTCTTCAATCTTN
+
CCCFFFFFHHHGHJIJGHIJJIJJIJJJJJJJJJJJJJJJJJJJJJIJIIJJJJJJJJIJJHHHHHHFFFFFFEEEEEDDDDDDDDDDDEDFDDEDEDDD#
@5MC
ATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGN
+
@@@FDFDFDHHFHEFIIIGHGCGGIFHIBHIGIIIEIIEGIIGIIIGGCBE?FFCDDHBCEHIIGBEGCHJJIEEDFFFFDCDB@@BCBD?@@DD?ADCC#
@5MD
CTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTN
+
CCCFFFFFHHHHHJJIJJGHIJJJJIIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJIJIJJJIIJJIHHHHHHFFFFFFDEEEEDDDD#
@5ME
GTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTN
+
@BBFFFFFCFFFHIJJJJJHIIJJJJJJJIJIJJJJJJIJJIJJJJJJJJJJHHHHHHFFFFFFEEEEEEDDEDDDDDDCDDDDDDDDDDDDDDACDDDE#
@5MF
GGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTN
+
???D?B::=ACA?@+A;C@<A@:32C:E**:?<CBDB*39?D<*?DA9B6:AAAA@A5;4)=.7'5@?>>6>A;;?:?AA>AB3>A8>:9AA:>99>A3>#
@5MG
CGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGN
+
CCCFFFFFHHHHHJIJIJJJIJIJJJIJJIIHCHFDDEDDDDDDDDDDDDDDDDDDDDDEEEDEEEDDDDDDDCDBBDDDDDDDDDDDD@DDDDDDDDDD#
@5MH
CTGCATAGGAGGCCTGGGGGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTN
+
@C@FFDDDBD>FABEFFG)<7@6@DDDCCC8BCDDD8>?CBD:ACDDD9>@A>CBB8CCC>@C:?CDB<BBBBC@@BABB89?844>ACDDDD7@BBBDC#
@5MI
TTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATN
+
@@@FFFFFFHFBFDBHHJIG@FGGHGIJIJIIJJIFIIGGGHIJDEDFGIIJJJJEEGHIIIGIJGGGHHHFHHH@DFBEDCC6>CCCACBDDDBCABAC#
@5MJ
CAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGN
+
@@@FDFFDFHHHDHGHGGIIIIGGGBFFHEIIJIIIFHIIIJIG9DAEIGHIJEGHFGGHJIGGEGFGAADDAC@BBCDCDDDBAB18ABDA@DDDDDBB#
@5MK
GTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJIIIJJJDFHIJIJJJJJJJJJIJJJJJJJJJJFIIJJJJJJJJHHHHHHFFFFEFFEEEDEED
@5ML
CTGTTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGN
+
@@@DDEFBFADHHG<CA@EFGGGHGGGGHHECCGHCCG<?DDFEDEFCAF9BDGIDBGH@EHCDGDCEE=>CCED@BCD?DCCECEACC;>;@BB?8?<C#
@5MM
GTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTN
+
CCCFFFFFHGHHFEIGHIGIIIJEIJIIEGIJJIIJIGIHHHJIJJJJGIJIIJJ@EHIJHFHHFFFFFEEDDBDBCEDDEDDDDDCCDCCCDDDDDDDE#
@5MN
CTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
CCCFFBDDFHHHHIJJIJJJJJJJJJJBHHIJFHIJFGIJJGIIFJJJJJJIJIIIJJJJHHHGHFFFFDACEECDDDDDDDD@CCDDDCDDDDDCDDD
@5MO
GTGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCN
+
@@@DDFFFDDB?FIIAGEGFGIIGFG?DCGIDFHDEIIHIICHIIIGG6@@FHGGIBAC7?AE?EDFFD>CCACD5>@CCDCCCDD;ACDECCCAC@C>C#
@5MP
TAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACN
+
@C@FFFFBFDDFHGIJIJJJJIIJJJJGIJGHHJJJJGHHIIIIJGIIJJIIJIIIFHHIIJGIJIIGGFFHFFEDECCEDCCDDDCEDDDDCDCCACDD#
@5MQ
CACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAG
+
CCCFFFFDHHHHHJGIIIJIJIJIJJJJJIJJJIJJIJGIJJJGJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJHHHHHGFFFFFDEEEEDDEDDDD
@5MR
TCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCN
+
@B@FFBDDFHDHFHIEIJIJJJJJHHIGGIGGIHIGGIJJJEAHGJIJBHGEFDEDEEDDDBDDC>>ABBCBCDDEDEDDDCDDD<CBBBDDCDDDDDDC#
@5MS
AGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
;?@DBDDDFHFDBFH88<CB>EHFGI>91:EHGHHI@BFHEHGBH3B.BC4==FGG@AC7?>CA8?BBC;>A>@@AB'3=5@C(::@?B3+2:>C>@C>C#
@5MT
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGN
+
CCCFFFFFHFHHHIIJJIJIIIJGIJJJIIJJJFHJJJJHIIEIIJGIIJJJJJDGIJJHHHHHHFFFFEFEDDCD=CDDEDDDDCDDEEDDDDDDCDDD#
@5MU
CAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGN
+
@@?DDEDAHDHHHIIAAFHICGIIIDGHIIIGGF@DGGIGB6857C@A9AC3>C>@CCDACCBCCCBBCB<AABCCCACCC@>C@CC@CDCCCCBC<<9?#
@5MV
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
@CCFFFDFHHHFHGGHGIJJJFHIJJJGIJJIDGHIIGGIJGIIEHFHIJJJJGIIJIIJJJJJIGIJHGEFFFFACEEEDCDBDDDDDCDC9AAB>CDD#
@5MW
GGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGN
+
B@BFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJJHIIJJJJJJJJJJHHHHHHHFFFFFFEEEEEEDEDDDBDDDEEDDDD<CDEDCDEEDD#
@5MX
GGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGN
+
CCCFFFFFHHHHHGIJJJJJJIIIJJJIJIJJJIFHIIIHIJJJIIJJJIJIJJEHHFFFCEEEEEDDDDDDDDDDDDDDCDDABDDDDDDDDDDBDDDD#
@5MY
CTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCC
+
<??A?DDDHFBHD<EC:EFBHCHIECHBGADEEHIBC19?F:D:BGDBGHDGBF@F@<DFHIIEGE>GGDCDCC@@DEHB7.=??CDEEAA>CCCDC;
@5MZ
CCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTN
+
@@@FDDAFFFHFHIEEGFHGHCCHIHFHIEGGHIEDEHJIBHGDGGFG?DBFEHGGIIFCGG@EGGGHHFFCEFD7@BCAABB(>@@:ACDDBB?ACCD@#
@5N0
ATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGN
+
@@CFFFFFGFHAHIHIIIIGEHIHGGGGGGIIJIJFIIIJJJJJGIJIIJJ@FHIEGGIIHFH?;7@CFCCECC@@CDACDCCCCDBD>ACC@CB@DCBD#
@5N1
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
BB@DFFFDHHHHHJJJGIJJJJJJJIIJIJGIJIIIJJIIJJIIJIJJJIJJJJIJIJIJJIIGGGFFFEFECECEACDDDDDDEEDCDDDDDEDDDDDD#
@5N2
TATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCN
+
CCCFFFFFHHHHHIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJIEHGHHHFFFFFFEEEEEEDDDCDDEEDDDDDDDDDDCDDDDDDDDD#
@5N3
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAGGTACTGTAATCCGTN
+
CCCFFFFFHHHHHJCGHIIJIJJJJJJJJJJJJJJIJJJIJJJJJJJHHHHHFFFFFEDEEEEEDDDDDDDDDDDDDDDDDDDDDDD>CDDDDEEEEDDD#
@5N4
GGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGN
+
CC@FFDFFFHHHHIHIJEGGGIIJCFHIIIJJJGFGGIGIIIDFDHIIJJIBEHIDEHFEEEFD@CEDEEDDDDCBC>AC@C9?CEDEDCCD@D8ACDEC#
@5N5
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@?@FFFFDHHHHHJIGGIIIGIIJIIJIJJJJJDIGIIJJIJJIIJJIGIJJJJIGHIIJFGJJIHJHGHGGFFF?CDFDDD;?BD=CDDEDDACDDDDD#
@5N6
CCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTN
+
@@@FFDDBFDFHBAHGIEFCHGCFDA?FGHG:?@FB><?B?9BFH@<BA<@ADG9@@@DGEA:?C;>?;@CC>=@;@B3(54>>@B<BB2>>C3((>A@:#
@5N7
GTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGACAGCAGAGCAACTGGACAGGN
+
CCCFFFFFHHHHHJJJHIIHIIIIIJJHHIJJJJJJHJJJJJJIJIJJIIDGIJJHIJHIJEHGHFFFFFEEDDDDDDDDDDDBDDDDDDDDDDDDBDDD#
@5N8
ATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTN
+
@@CFFFFFHFDFBHIIJIHIIIJIJJIIIIJJIGGEGIIJGIIJIDGFHIIJGIIJIIJJJIHIJEIEEIGHIGGEIGE@CHEHFFFFFDFFCACEEDDE#
@5N9
TTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCN
+
@C@FFFFFHHHHFJJJJJJJJJJJJJJJJJJJIJJIJJJJJIJHIJJIIJJIJIIJHJJJFHHGIJJJIJJJJIJIJIJHHHHHHFFFFFDEDEEEDEED#
@5NA
CTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGA
+
CCCFFFFFHHHHHJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJ=FFHIJJHHFFFFFDEEEEDDDDDDEDDDDDDDDEDDDDDDDDDDDD
@5NB
GATCGGAGCACACGTCTGAACTCCAGTCACGTGAAACGATCTCGTATGCCGTCTTCTGCTTGAAAAAAAAAAGCCGAGCGGAATAGGGGTTTTCCGGTTGN
+
@@@DDDDAAFHBD@:CCGFEFHIBGGHECHF???FFHA08/B9?7;@=B;@'56;?=A:=?CD@DEAB8;-&&((&&)009&08A:38&&&2<3(8&)&)#
@5NC
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCAGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
CCCFFFFFHHHHFHJJJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJJHHHHHFFDDDDDDDDDDDDDDDDEDDDD
@5ND
CATATATCCAAGAGAAAAGATTTCCCATAGCAGCACTCCAAAGGACCATGTGTCTGTTTTAGAAGTGAATATTCCTTCCATGAAGGCCTCTGGGGGCATCN
+
=?@DDBABACFD?BE;FDB;?FHBHIIIE><F?CFHFB;FDB?;0:?B??F?G?89DFDHA=<7=../8CC==@@7.?ECHHHD>>B=>@C;AC88;,99#
@5NE
GCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGN
+
CCCFFFFBFHHHHIJJJJJJJJHJJJJJJJJJIJJJJFHIJJJJIJJJJJJJJIJJJJJJJIJJJJJ@GIHHHGCDEFFFFEEEEECE@CBDDDDDBDDD#
@5NF
CTTTTTGAAGACTGTCAACTTTTTCTTTTAGCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACN
+
CCCFDFFFHHFHHIHIJJJJJJJIJGGIIJIJJJIIIJJJIJIJJJJJJJJJJIIIIIIIJJJIIJJJJJJJIJJHHGDEFFCCEDEEDC@BDDEEDDDC#
@5NG
CTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGN
+
BCCFDFFFHHHGHJJGIJIGHIIJJJJIIJHIJJJJIIJIIIIJJJJEHIJJHHHFFFFDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDE#
@5NH
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCFFFFFHHHHGJIHIIJJJJIJJJJJJIJJCGGIHIGHIGI=CHIDHHIGFFFFHFFFFCEEDCCDDDCDCDCDDA@CCDCDCCCCCCDCCCDCDCCC#
@5NI
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
@@@ADDDDFFFH?EFHGFGIIIGIIEGGHGIGIIIIIIIIIIIIIIIIHIIIIIGIGIEEGGHEGEEHFHEHEEEEECCCCCFCC@C?B@BC@BB55>0?#
@5NJ
GGATTTTGTAGATCTCCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGN
+
@@@DFFFFDDDDHHDEGGGHIIID<HHIGIIBGGHEGGGIIEIIHEHHGGGIIIBHIIIAEHA?;>EAD@B?@;=@CCB@CCC>B:??:8<>AB@950<5#
@5NK
GGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCA
+
BCCDFFDFHHHHGIJJJIIIIIIGIIJIJJJJJJJJJJJJIJJJIEIJEIIIJIJJJHHHFFFFFDDDDDDDDDDCCDEEDDDDDDDDDDDDDDDDBDD
@5NL
CGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACAAATCACATCGCCATCTTCACCTTCAAAGCTTTCATTTATGCCTCCACTGTTGTTTN
+
??:B=?8ACAFBFE@:AFE?3A+C3F32<A++A+:BEFFF*:??GDF><F<B4?)?F(7)=88=CFF:CC:)=D3;)...7=;3;)).66(;@A;5((,5#
@5NM
GTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCN
+
@@@DFFDDHHHHHJJIIGFIJJJJJIBHEHGIHIIGIF?FDHHIJJIIJEGHIJ@FGIJ9BFBFFGIEHIIIJIEGGGFHHDEC@CCDDDEDEEDECDDD#
@5NN
GCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGN
+
@@@DD+=B==A<?<;CE<AAE@EG:CBBDHG@@FBCGDF1???@FBFGGECGFCGHGEGEBEH;;=7<C>@@>5>;CC>;A@>C@CA@;>@@CC:>C<C?#
@5NO
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGN
+
@CCFDDFFHGHDHGIIIIAGCGHGEGIGGIIGGGGGHIE<DHE>C0?FAB@GHBH=CGGIIJEH=CG7@C:CA@C>BEDCEDDDD?BD@DB9CCCDCC:@#
@5NP
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTN
+
@@CFFFFFFHHFHI@FIIJIHIJIJJIGIJJJIJIJJJJJJJJJJIJJIHFFDDDECEDDDDDD@CBDDCDDDDEEEDDDDDDDDDDDDDDDDDDDDDDD#
@5NQ
GCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCN
+
CCCFFFFFDCFFHHJIIEGIGIIIJJJJIIJFGFGHGHGIGG:CDFHCHIGIDHIJIIIIHIGII@FGIG=BFBC;CAABDDDDDDFDDDDDDDCCDBDD#
@5NR
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGN
+
?@@FABA?HFHHHGGGHIGHIGHGDHHGGIIIIGIIIIICHFHDHIEHHHIDHGGGGDE7CC>EH@EEECABB?BD>?@CECDC@3@C@;CDDDDDCCBD#
@5NS
CTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAG
+
8??DBDD:3CDDD@EE4<CBF?FA:CAFDDEF<E>BEI>;:)):@??;7@AAADDA4/375<<:>>DA::>>A44>2<8155&0)>:>>:999<A>A3
@5NT
CTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGTAC
+
C@CFFFFFHHHGHJJJJJJJJJJJJJJHIJJJJJJJJJJIIJJJJJJJJIJIFIJIJJJIEHHHFFDCDDDDDDDDDDDDDDDDCDDDDDDDDDDDDBD
@5NU
CTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTN
+
@@@FFFFFFHGFHDAFGEED?@FG>4?FHHIIGHIICH@BHGIEDFDGCHFCF?C7CEE@GDEEHBA>AC>CCCC@CCCCCCCC:9(9(:>CAA:>CC>C#
@5NV
GTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCN
+
@@CFFFFFHGHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJIIJJJJJJJJJJJIJJJJJIJJJHHHHFFFFFFEEEEEEEDDD#
@5NW
CTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJIJJJJJIJJJJIIJJJJJHIJJJJJJJIJJJJHIIIHHHHHHFFFFFFFEEEEEE
@5NX
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@@=DDDDDFHHBHIIIIIGBG@FA>EFGHGGDEGGHI<?BG<?BGIICEH?BFHGGE@7@@?EE,,9;>C;>>:<@B??C@CCAC>>C@>CAB>59??>C#
@5NY
CGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCN
+
CCCFFFFFHHHHHIJJJJJJJJJJJJIJJIIJJJJJJJHIIIJIJJJJJJJJHJJGIJJJJJJIIJIJJHHIIJJJJJIHHHHHHFFFFFEEECEEEDEC#
@5NZ
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
?@@D<BDDFDFFGIGBGGICGI@?FH@GHGC?DGB9FHGIGGGHCEGGIIGEGGE;CE@E7AAHB>?DCFA>BDD9;=(5>:ACCC@AD:5<C@4@CC>A#
@5O0
CTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTN
+
@@<??;D??D:<CAFGAFHEGIA@CH@DB;ABGCCGGA?FFG?DGIFEADFF@4=?<@AAB@BB??@?BB@ABBBB<8@BDBBBBBBBABBABDBBB>3+#
@5O1
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
CCCFFEDFHHHHHJJJGIJIIHGGIIJGHIJJJJJIIJJJIIIIJJJJIEHHHJIIIGHIIJJIJCFIBDEHEECHFFFFFFFDEE;ABDDDDDDBBD5>#
@5O2
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CC@FFFDFGHBFHHEGIGGGGGHHIGGIIGEHGGEHGFGIIIIHIIJJIHHIGIIGIIIJIIBHHIDEEEHGFFFEDEFCDB'8;==CCDD@CCCDD@BB#
@5O3
CCTCCATTTCTCCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATN
+
@@@BBDFDFDBBDDHHIGCHIGE?FGIIIGHGIII<FDDFA<D??<FDF>F<DG=?DFHECEGEGE4C@DFGIEAAGEHACCCE;>;7;@BCA?@@ACCC#
@5O4
GGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGN
+
CCCFFFFFHHHHHHIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJDHIJIIJJJJIJJIJJJHIJJJJJJJJCHHHHHFFFFFFFEEEDEEEDDD#
@5O5
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
?:?DB?DD??A<CGIA?C)@:?):?:DB9*008?FDFF@FFEFFF@FC;DCEE>?E>=AB;BBBA>;A:ABBBB>3;55::5;;3:5,5:>258>B@B:
@5O6
GCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACC
+
B?@FDFBDFHHHHJIJGHJIJIJIJJJIJJJHHJIIGIJ????FHIIIIJJGHIJIIIJHHGFFFFFFFECBEEEDDCDDEEDDEDDDDDDDDCDDDB>
@5O7
CGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCACCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFFEEEEEEEEDDDDDDDDDDDDD#
@5O8
GTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTN
+
B@@FFFFFGHHHHJJJIJJJIHHJJJJHIJJJIJIIIJIIIIJJIIJJIJJJIJIJJJJJJJJJIIIJIIJJJJIIJJJJJGJHHHGHHFEFFFFEDEDE#
@5O9
CATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGN
+
CCCFFFFFHHHHHEGHGGGIIJJJJHHIJJJJJJJJIJJJJIJJJJJJJBEHIIJHHHHHFFFDDDDDDDDDDDDDDDDDDEDDDDDDDBDDDDEDDDBB#
@5OA
GGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CCCFFFFFHHHHHJJJCGIJIIJJJJJHHJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEDEEEEDDDDDDDDDDDEDDDDDDDDDDDDDDDDCD
@5OB
ATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGN
+
@CCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIHIJIJ4BHIIJIIGJJJJJJJJJJJJHHHHHGHFFFFFF#
@5OC
AGTCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCTAGAGG
+
@@CFFFFFCFHHHGIFHIJGIJJJIIJJJIIJIIGIJIGIJGHIGIIHFGHHFFFFFFEEDDECBDDDDCDDDDDDDDCDDED>CDDDCDEEED@C>CD
@5OD
CCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTN
+
CC@FFFFFHGDFHEIGJIIIJIJJJIGHHDGECD9CDFDGBBFBFHGDEBGHHHIGAHGIG@<B>==FDEHGI=E>E??B?7>;>>ACCDCDBBBDD?AC#
@5OE
TGCTATTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTGAGCCCAGCACTGGGTCATTA
+
<@@DFDDFDFHHGFGIIGEGIIJJIIB@FEFEGIFDGHDGIGGHHIJCFDEGCCHGH?BDG=BFHJID6@EEFFEEDDE>;@CDD?BCDCCBB<ABDEA
@5OF
CTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTN
+
@@@DDDDB<FDDFDD@EG4ACAAEAAEG9CE4AFGHIIIEHFHIGE<?BBFAHI@D@@EHFFBGHGFFHC=@;C@;==EEHAC??ACEC@CD@;>>>C@C#
@5OG
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
@@@ADDDFGHHHHIIIAEFHIIHIAHHGHHGHIIDEGHGIIGIHGHIBDHIEDG7FGEFIIG@EHGBEEDCEFFFEEEECECC;BBA>5@CC>CCCA:@>#
@5OH
CCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@7ADDDD:?AD<FHCFGHBGCHHAFECGCC?DHHIBFE@DGIG>GEHBFHG>D@FIEIGHG=EH:=;=C:;B@@BC>AC?(5;B(58?3::838?(+:
@5OI
CTGTTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
CCCDFFFFFFGGHIJIIIIJIEHGIIIJJIJFDGGGIIGIJJJJGHFHGIIJDGIIIGDHIGGHHGIJJIGEFFFBEEEDEDDDDDDDCCDC<@CDCCDB#
@5OJ
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTN
+
CCCFFEFFHHHHHJJJJJJJJJJIJJIIJJJJIIJIJJIJGHIJJIIIJHFFDEEEEEDDDDDDACDDDDDDDDEEEDCDDDDDDDDDDDACDCDCDDDD#
@5OK
CAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCN
+
@@CF=DDDHCFFDGHGBHHIIIGIIIGI@FDDGC????EFHEHIEIHGCBDHFCFBFBDF9BGHHEBEEEHHIGGGHEEE@=DHHE>=CEDBBE?@BDEC#
@5OL
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGA
+
=??D+=ADFBHDHIEHGG=CFGEHIICHGIIIEHIGHIGIABBGI?8?BFE>CCGGD8;<<9>ACCC43@+>BCC@CCB>@CB<@BBBB8@CCECCCC
@5OM
GTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGN
+
@?@FFFFFHHFHFIIJJJJCFEGGJDFHIJJIJIJGJIHHHFFFDDDDDCDCDDDDDCCDDDDDEDDDDD>CDDDDDCDCBDDDCDCDDDDDDDCDBBBD#
@5ON
CCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAA
+
CCCFFFFFHHHHHJJJHJJJJJJIIIJJJIIIHJJJJJJJJJJJJJJJJIJJJJJHEHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDD
@5OO
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCN
+
@C@FDFFFHHHHHJIHEFDFFHHGIFFHIGIIJJIJJIIIIJJEGFFFGIIIBFHIJJJIFGIBDHHHFHGGFFFEEDEEFEDDDCBD=?BCC>@CDCDD#
@5OP
CCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCN
+
@CCFFFFFHGHHGJIGIJJJIJJJJJJJJJJJJJIIIIJJJIJJJJIHGIGIIIJJGIJJIJIJJJJJJJIGIJIJJIJHHHHHFFFFFDFEEFEDEEED#
@5OQ
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@@<DDFDDF?DHHFEBEGHIIIEIGEHGIGB==GBHEE@DBFABFEHGHIICGGDDDDFHHGGGGEEGHIGII?EDBBC@CECED@CCEECC@C@CB9?C#
@5OR
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
??@DADEDHHHGGGBG@HBAEECAFHIGCHAG@ABBBGG>GAHIIIEHHD?DHHEHGEBFGCFCEHDGGHFHGF7@DEC>>ACECCCCCCACB:@CC>>
@5OS
GGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCGN
+
<;?DBDDDFDAHHGIIF@HGEGIGHEHGB@GGHIIEHFGHHHFDFBHHHIIIEGGHEHBDEHHFA;?@CD@CACCCCCBBB?BBBB35585509AB<><9#
@5OT
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
BCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJIIIJJJJJJJJJJIJFHIJJJIJIJIIJJIJJJJJJJIIHHHFFDEEEEEEDDDDDDDDDD?CDDCCDD#
@5OU
GACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACA
+
CCCFFFFFHHHHHJJJJJJJJJJJJHIJJIJJJJJIIIJJJIJJJGJIIIJJJJIHJJJJJJJJJJJJJIJJJIIHHHGFFFFFFFECEEEEDDDDCCD
@5OV
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGTN
+
@@CDFFFFFFBFHHHFHIGGIIHGHGBFHJJIJGGIJIGIIGIJJGIIIIIIIJJGIJJIIJJFHIJJJIHGHFFEFFDEEECADDDDDB:ADEEDDDCD#
@5OW
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGG
+
@@CDFFFFDHHHCGGIJCGIJIIJJJIJIJJIJJJJJIJIJEHIJ>FICHDHIGGGGFI;CGH@EEFEHHEEFEFDFD>CECDCCD@CD@DDDDD
@5OX
ATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGN
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJIJJJJJIJJJJJJJJJGIJJJJIIIJJHHHHFF=BDDBDDDECDCDDDBDDDDDDDD#
@5OY
AAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGA
+
CCCFFFF:CFFDFIGHGHGH>CFF>HGHIIHEHGIGECCHHCB;@DCCCECCB?BC@CCCCECCAC:>@C<>C@BCB>BBB>ABB99>8?@?>>ACB?
@5OZ
GTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAA
+
@@BFFFFFHHHHHJJJGHJJJJJJJJJJJJJJJJJJJJJJIIJJFHIJJJJJJJJJJJIIJJJIJJJJJJJJJJJIJJJJJIJJHHHHHFFFFFFFFEE
@5P0
CATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGN
+
CCCFFFDDFHHHGIIGHGH<BCFHCGGHGDGIIIGEHIIGGGGIIEICCGGGHIIIGGIIHEFE@BCDFCCCEEDEDCD@DACDDDCCDCDDDDCB?BDD#
@5P1
TCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTN
+
C@CFFDFFHHFFHGGJIJJJGIIDGIIJHGGIFIJIEGGIIIIIEHFHIJIJJBFFHGEHAFHGIGIEEHHFFFFFFEEDEECCADDDDACDDDBCCCDD#
@5P2
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCC
+
CCCFFFFFHFFHHJJJJJJJJJJJJJJJJJJJJIJJJJJIIJJJJJJIIJJJJJJHHHFFFFEEEEEEEDDDDDDDCDDDDDCDDDDDDDDCDDDDD
@5P3
GCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGN
+
CC@FFFDFGHHHHGGIIIJIIGFHIIEHGIIIJIJIJJJ@FHIIJJIJIJHHIHICBFEHGIIDHGJJIJHGHHHHE?CDEDCDDDBBB@@BDEDDDDDD#
@5P4
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
CCCFFFFFFHHHFHIJJIJJJJJJJJJJJJJJJJJJIJIJJJJJJGIJJJJJIJIJJIIIGIJIIFGHGHHGFFFFFEEECEDDDDCCDDDDDDD5<B<B#
@5P5
CTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTN
+
CCCFFFFDHHHHGJJJJJJJJJIJJJJJJJJJJIIJJJJJJJJIJJIJJJIIJJIJJJJJIIJIJIHHFGHHHFFFFFFFEEDEEEDDDDDDDDDCDDEE#
@5P6
GTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATN
+
CCCFFFFFHFHHHIIJIIJIJJJJJJCEHIIIIIJJJJIIJJJIIIIJJJJJIJJJIIJIHIJIJJJJJJJHHHGHHHFFF;BCEEDEDDDDDDDDDEDE#
@5P7
CAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGG
+
BCCFDDEFGDFFHIIGIIIGIIIJIIGEHIJJHIGIGIGGIJIHIEI8BGIGEHFF7AHFFFFFBCEDCCDDDCBDCCCEDCDDDD<A@CD@ACCDAAD
@5P8
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
@@@DDDDAC?C8F@G4A?EFBGFFHGIGFFEHG>FHHDDAGH?BF@?BDFGIGIBHE<DEGGG?CA=EEB;C@CCC>@BB:@@CCCCBBBBBBC:A>>@
@5P9
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
@@@FFBDBHHHHFICFHEGGGCGIHGGGGIJIJIJJIIIDGEGGHIIJJIEHHHIJJFGHJ59A>;@>CCDBDBBBCC@CCCCCDDC@BDD@>@<A@C@C#
@5PA
TATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTC
+
@@@?DFEFBHFHHGGHEGIGIHIIHIJEGGGIEHHH@?EHEGFEDFGIEHIHGIGAHHGGGIBCBFGIIJ@@GEGI>=C@@CCEAHD;?DF@CAACCCD
@5PB
CGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAG
+
@@@FDFFFFFHGHJGHJJJIJJIGJIGGFGIIIIIHIGHIJIJIJGHIGHHJJIHJJICFGIJIHIJGGHEEHHFFDDCEDDDEDDDBBDD>B<@C9
@5PC
CTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACN
+
CCCFFFFFHHHHHJIJJJIJJJJJJJJJJJIJJIJJJJJJJJHIJIJJJJJIJJJJJJIHHFFFFEDD?BDDDDDDDDDDDDDDDDDDDDDDDDDCDDDD#
@5PD
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHGHHHHGIIIJGIHGIJIJIJJIJIHIGJIGGGIGIIHJIJIEHIIJJGHGIIJBEEFFDEFFFCEACE>?@@CDDEEDDCDCDDDDCCDD
@5PE
CCCATAAACACCCATGCTACTGGGGTGCTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJGH11:C@??FGEHGGGGGICIGCHGGIJJIEHFHEEFFDFBEECCEEBCCCCCDDDCDCDDDCCDDDDDCDDA
@5PF
AGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
@@@ADFABBFDHFGIEHIBBHGHIIIGII@GGIIIIAFADHGGGGGH<FEEDDGGGBAG;CH:A?EBC;7@;;@@CCA??9A>>C@C>>@@C@A?>ACC
@5PG
TTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTN
+
C@CFFFFDHHHHHJJJJIJEJJIJJJJFHIIFIEIIDHHIGGIIGGCDDGFCHHICGFHIJIIIHGECFGCEHEGGCHGIJJJHHHHHEHDDFEEEECEC#
@5PH
CAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDD#
@5PI
GGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCN
+
CCCFFFFFADFHHIJJJJJIHIIEIIIGIIIIIGIIIJCFHIIIHIIIJJIIJJIJBHIDGHFFDDA@CDBDBDDDDDDBCDDDDDDDDDDD9@B?:C:@#
@5PJ
CGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTN
+
CCCFFFFFHHHHHJIIJJCHHJJJJJIIIJJJJJJJJJJJIJJIIIJJJJJJJJJJJJJJJIJJGGIIJJIIIGJJJJJJJHGHEHHGFFFFDEDDDDDD#
@5PK
GAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATN
+
@@@FDDDDDFHGHIIGIIGIGIFHGGIJEGHGIIIIGGHFGIGGIJIIG=@FHCEGGHICCEEHEFFFFED@@@A>CCCDDCD@CCDCCDDCCCDCCDCC#
@5PL
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGN
+
CCCFFFFFHHFFHJJJGIIIJJEIIJJJIJJJJJJIJIJJJJJJGIJIIGHIIFGEGHII@FHGIGGIJEHHEA=?C@BDFEFEEDCEACDDDD?BADCC#
@5PM
CTGCAATTGAGACAGCACTGGTATGTCTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCN
+
@@@FDEDFBFDDFDFHIIGIGHGIE9CHHGGBFHIIGEGHCHGIICFEHGGGGIIEEHGHIHIIIGIFEIGECEAHHGGFFFFFC?CDD@BB=B>??<CC#
@5PN
TGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGT
+
CCCFFFDEHHGGHFFHFDFCHHHAFFHGGGHGHHIGIGHIGGIIIJGGIJIIEGIJFGFHCGGIGICEGIACEFHFFDCDDCEECCDDDDDDDDC@A5
@5PO
GCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCN
+
@CCFFFFFHHHHHJIJJGIIJJJJIIIIJJJJJJJJJJJIJJHIJJJJJJJJJJJJIJIIIHIIIJIIIIGIGHIIJIIJJIHHHHHHEEFFFDDDDDDD#
@5PP
GCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATN
+
CCCFFFFFHHHHHJJJJJIJHJJJJJJHIJJGHJJJJJJJJIJJJJJJJJJJIJIIIJJHHHHHHFFFFFFEEEEEEEDDDDDDDDDDACDFEEEDDDDD#
@5PQ
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCN
+
@BBFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJIIJJJJJJIJJJFHIJIJGHIGHHHGHHFFFFDAEEEEDDDDDDDDDDCCDDDDDDDDDEDDDCDD#
@5PR
CCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATAC
+
CCCFFFFFHHHHGGJIGIIJJIIJIJIIJGEHIJJJJIJIJJJJIJIJJIIIIIIJJJGFHHIIJGJFIGHHGHGEFFFFAADDDDDDDCCA>,5,5>
@5PS
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@@@DDDADF<DF3?C<FGBEHIIBDFFCFIEGC>E>DGF8??BD<F8BFGIBEE8B=FFFEFF'5=D8>>;A;>AB@@;58<2(55:ABBB>B@@::?@:#
@5PT
GGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCN
+
@@BFFFFFHHHHHJGJJGIJJJJJIIJJJJJJIJJJJJFGIIJJJJJJJIJGHFHHFEFFFDDDBCDDDDDDD>CCDDDDDDDDDDDDDDDDDDDDCDDD#
@5PU
CCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATN
+
@CCFFFFFHHHHHJJJJHJJJJJJJJJJJIJJJJIJJFHIJJJJJIIIIJJJJJJJIIJJJIEIIIIJJIIJJJJJJHIJJJJIIJHGHFHGHFFFFFFE#
@5PV
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@@@DD?DDF>HBDGE?CBH?FD?F@FEF9DFGIICD?B@G9??DFCH2?FB9//=F<8.8CGHA'5=>3;6>;>;;>;=2?B@<58>::<?:9?:>>@CC#
@5PW
CAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAAATTTACCGCATGTAATN
+
<@@@D>+AD6DBBFEE<<E>FG<EGI>FEF;BFEEE@??C)?D>49?:9DGFDD??*/7@FAGGGE).7?3)).)..);)6(((.(;A;>58'8/<:5;C#
@5PX
CTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
CCCFFFFFHHHFHIGIJJJJJJGGIJJHHJIJHGHJIIIJJGGIJJJJIHIJJIJJJJIIHHHHHFDFFCEDEEDDDDDDDDB:@CCADDDEDDDDDDD
@5PY
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAG
+
CCCFFDDFHHHHHIIJJIJJJJJIIJCGHDFGIJJJJJJJJIJJIJJJJIJJJJJJJJJJIJJHHHFFFFEEEEEEDDDDDDDCBDDDCDCD
@5PZ
GGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
B@CFFFFFHHHHGJJJJJJJJJJJJIIJJJIIJJJJJJJJJJJJIIJJHIHIJJIIJJJJIJJIJHHHHFFFFF@CCDEEEDDDDDDD@CDDEDDDDDD
@5Q0
CTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATA
+
CCCFFFFFHHHHHIJJJJJJJJJJJIIJIIJJJJJJJIJJJJIJJJJIJGIJJIIJJJJJIJIJJJJJJJIIGIIGJJJIIJHHHHHFFFFFFEEEDEE
@5Q1
CCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCTAGTTCTTCCTTGAGTTTTTCCTTN
+
@@<DDDFDHHDGH@BH@HIIGIGGGHGHI9AFHEFIACDFFHIIIIIIII@?DGGHIIIIGHIGIGGGGGIEHHGIIIG@EAHFHHGFFCFDEEECECCC#
@5Q2
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJIJJJJJJJGHIIJJJJJJJJJJJJJJJHHHHHGFFFFCCDDDDDDDDDDDDDDDDDDDDDEEEEDDDDCD
@5Q3
GTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATN
+
CCCFFFFFHHHHHJJCFHIIJGHJJJJJJJJJJJJJJJJJBGDHHIHIJJHIHIIJIJIGIHHJFHIHIIFHEHHFFEDDDD@BDDDD>CCDDDDDDDDD#
@5Q4
CCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCC
+
CCCFFDFFHHHHHIHIJGHJJJJIJJIJGIJJIGIGIJIJJJJJJIJIIHIJIJIJIIJJJJJJHIHHGHHGHDBEFFFFEEEEEEEDDDDDDDDDDDD
@5Q5
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATGCCTGGGTGGTCTGTGCATATCCTTGAGGGGGCTGGN
+
:=?D:D?:ADFAD<<A<AA3<:AF<<992<;EFFID9DFDFG<GDGIII<?*/?9BF8;C=BCCF@F:=D@@=8,7;7)..6@66>;;5;;5(,,&0005#
@5Q6
GCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTA
+
CCCFFFFFFHHHHJJJJJJIJJGJJJJJJJJGIIJJJIIIIIIJJJJJIJJIJJJJJJJIJIJIIJJIIIJJJHGIIJJJJJGHHGHHFDFFFFFEEEE
@5Q7
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@@@FBDDFFGFDHIHFGHHGGIICEGHGGIHIJJIJJJJIGGHGGIGGEGGGGHEEG;=CHGFH'9A9@CCC;@BB;<BDDDCDDDDDDACDD@DDDB:>#
@5Q8
AGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
?@?DDDDD?:?;CF:AD?1)<<AE4?;CGE9CD?DDEG:G@GFFFEFDCBBFFIECGFFFI;@E@EEAE;AE;?B=>>@B>;>A>ABBB?8<>>>@
@5Q9
CTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAA
+
@@@?D?BDHBFAFBEHAF>FHGHIEHGGHEFF=GHIIE9B:F07?B==F@GCGCHIIGF=BD>BDC><=A@>@C@@CDECCCCCCC@CCBC:44AC?AA
@5QA
AGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGN
+
@@CFDDDBBFDDFDFHIGIEAEEGBFGGF=@F@CHCADHHHE<DD>C@ECECCCC;AACD@>:<<@8?BB3<BD0<B(<+8?ACC??9@@BB@>D5><?C#
@5QB
AGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTN
+
;=@BDDD?F8AFF<;C??FCC9FB;FF;CFFGI9FFIIF?FECFEFIIECFI;=CFCC)7=C=E;5';>=(6=?;A8((,:(:A3,<(+8((29??@><3#
@5QC
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
CCCFFFFFHHHHHJJGGIJIJIJAHHHGHIJIJJ?FHIJGGIJJJIJJIJIJIIJJAEDHCHHHFFFBDEEEEEDDDDDDDDD@CDDEEDDDCDDDDDE
@5QD
CCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATN
+
@@<BBDDAFHADHHIEEGICHHFAEGGGHFGH?DAFC?BFDGF@G1;CAGEADEE9?=ADBE:BB??=?9?>CACCD+4@CDDD:49@?C:@CCC>:?AC#
@5QE
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
CCCFFFFFHHHGHIJHIJJJJJJJJJJJIIJJIJJJJFHIJJIIJGGIJJJGGIJJJJJJJJIGGHHHFFFECECEDDDDDEDDDDDDDDDDDDDDDCD
@5QF
GGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTTTTN
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHFCDDDDDDDDEEEFFEDDACDDDDDDDD?CDDDDDDDDDDDDDBDDBDDDDD#
@5QG
CGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACN
+
CCCFFFFFHHHHHJJJJJJJJIJIJJJJFHHIJIJIJJJJIIJIIIIJJJJJJJIJJIHIJIJIJJJJJJIIIJJJJJIJJJJJJHHHHHHHHFFFFFFF#
@5QH
CTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTN
+
CC@FFFFFHHHHHJJJJJJJJJJJJHIGJJIJJJJIJJIJIJJJJJHIJJJIIJIIJJJJJJIIIJJJJJJJIHIJIJJJJJHHEEFDFFFFFEDEDEED#
@5QI
CTTGCCAGCAAAGCAGTAGTTGGGGTTGTAGTCGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGN
+
@@?D=??ABAAF?;GHAFH3<<<<@11@::?F??688DDBHEF@88;FH@-=7:8BCA;;A?>55(55>5,:,>CC::+8?83::>343+>:AC>4>C44#
@5QJ
GGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCN
+
CCCFFFFFHHHFHJHJIJJJJJJJJJJJJJJIJJJJJJJIIJJIIIJJIJJJJJJJJJIJIGGHIIJGHGHHHFFFFFFEEEEEEEDDDDDDDDDDDEED#
@5QK
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
@C@FDFDFHHHDHGGIGIIGIJJGGECHGGIIIGHCFHIGIGIIEGFDEEHIJ?@FG;CEHHHHEEDD?CABBDBDDDDDDDDDDDDDDCCCDDACCCCC#
@5QL
GGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCC
+
@@<DD?8AB?:AFGDFH@H>BCEHGEDABDHHBBDC9F9BBB?BFGEBDHICD7C;BGIA@;=@;5@E;=?BBEEEE>BC@;;ACCC?:5:@DC:@:3+
@5QM
GGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGC
+
;@7BADDAAA68@FEB6B1?CC8BBCC>CCCC@B@/296573@CCCCCA??CCCC:@BBBB@;B8?@<>>ACCCCA?0589>CCCCC3?:?B:AB>5<B
@5QN
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
CCCFFFFFHHHHHHJJJJJJJJJJJJJJIJJJJJIJIJJJIIJJJJJJJIJJIJJJJJJJJ:BDAEEEDDDDDDDDDDDDDDDDDDDDDDDBDDDDCDDD#
@5QO
CAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJHIJJJJJJJJJJIJJIJJJJJJHHHHHHFFFDEEDE;CDDDDDDCDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@5QP
CTGATTTGTGGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGTTTTGATTTTCAAGCACTGCCACTCTGTTTTCTAAACATTTCACN
+
?@?DBDDD=ADFFIC:<EEIH:<CHFHF2<<?EEEGDG@FIE9F9BB:9?D?B?DFBFIE=6=BBC@FG@FFCF@EEE??EAB;;?>BD@@A@;>AD;@>#
@5QQ
GCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCN
+
CCCFFFFFHHHHHJJJDDDDDDDDCD@CDDEEEEDDDDCDDDBBDDDDDDDDDDDCCCDCDDDDEDDDDDD;BBCDDDDDDDDCDDDDDCCCCCDDCCDD#
@5QR
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCDFFFFHHGHHIGDHGGEHHGHIHIIIIII)@GHDFGGIGH@FHIJJJIGHHGFHFFFFFCEECEDDDDDDDDDDDDDDDDEDDDDCDDCDDDDDDCD#
@5QS
GTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGC
+
@@@?ADDDHFD8D@AAFA>H@EHB<F>HDHIICGDGHGGIIIEHIG>>FGD@;FH=C@C8@CGHGHCE@EEDE>;>=A>>@?BC;:>5:AB?9A@CCC
@5QT
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
CCCFFFFFHHHHHJJJJJJJIHIJJJJIJJJJJJIJJIJJIHIJHJIJJJBFHIJHDDDDDDDDBDDDDDDDDDDDDDDDDEEDDDDDDDDDDDDEDDD
@5QU
GGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCC
+
@@@DDFFF:DHFGIIIGIJJJIGJJJJJJIIJJIGIIIEGGGJJJJIJJGHIJIHJJIHIGIJJJJIIGIIHIHHGHEGHGHGHHGFFFFEDDEEEEEE
@5QV
CCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAA
+
@@CFFFFDBDCFFGEEHGIGDHGIGIGGECEEHFFGFGGHIIGHIDFHDHIGEGDHEEGFHHGGGHBGIAFFEHHIIGEHEF@CC@BCCEC@E@@BDDC
@5QW
GCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCN
+
B@CFDEFFHHHHHJJJDDDDDDDDDDDDDDDEEEDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDBBDDCDDDDDDD@CDDDD>CCACDDDCDD#
@5QX
GTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAA
+
@@<BDDDDAHFFHBHFGI@EHFHCHEGGHGIIGBGHGGEFGGGGGGCHEGG@C>CDHGCAA;CGH?EE>EBCDEDCDCCCCCCC@CBBBBBBBCCCCCC
@5QY
ATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATN
+
C@@FFEDFGHHHHJGIIJGIJIJIJJFHHJJJJJIJIHIIJIJBHIIJGHEGGEIIFHHIGIGGGIJJGGHIJJDHHGHEFFFFFD@BD?CCC>CDDECC#
@5QZ
GTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTN
+
@?@DFFFFHGHGHGHEGGGIJIJJGHFHIGE?FFHIJGIGBEFFGGDDDDHGIIEDGFGGGGGIJJJIIEFGHFFFHHEIIJIHGCHEHFFFFBBCBCEC#
@5R0
CTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTN
+
@@@F=DFFHGGHHIJJJJIJIGCGJJJJJJGGIJJIJGEHHGIJIJJJJJJJCGIHJIIJIIJJIEIIIJJIJJJJJJIJHHHHHGFDFFFFFDEEECCC#
@5R1
TGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGN
+
@CCFFFFFHHHHGJJHHIJJJIIHIIJJJJJJJJJJJIJJIIJIJ?FGFHIJJJJJGJJJJIJGFHGHHGHHGHFDCD?BDDEDCCCDCCDDDDDDBDDD#
@5R2
CTTCTCTTCTTTCCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCAT
+
?@;;DDDDFDBH<BG@EDCFHDGCHIGEH9EFGHGBFG?F1):??BD?DDEEC8;F=FHIG;CFA=DEADAC@EEEDBDEA@CCD@DC3>@>=C@>@>>
@5R3
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@@DFFFFHHHGHIHIJGGHFHIIJJJJIJIIGIGIGGIJIIFJJJJJGGHIIIJJJJIJJHGGIIIIHHHFDDB<BCDDC@CCCCBCCEDCDDDCCDD
@5R4
TGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCN
+
@@@DBDDDFD>F??GB@;FDDDFC@DHDGAEHACFECHIHEBDFG9D@?B;7CCGGIID>7@;AH<>/?C@A?AACC?<@CCCACC:AC?BBBB3&)2<<#
@5R5
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
???DA:D;??DDDE9E@E,<3A3811))0?D<D0*?DAD=)8B8=BD@CA@CDDDA<(,.?;6@@;.>(;>>?AA<:(>>;>>:>AA:=9<AA<94(8
@5R6
ATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGN
+
CCCFFFFFHHHHHJIJJJHIIJJIJJIJJJJJJJJJIIJJJJIJJJJIJJJGGIJJJJJJHHHFF@BDFEEEDEDEDDDDDDDDDDDDDDDDCDDBBDDD#
@5R7
GTCAGAGTCTTCATCTGGATCTACAGGTGGGCCTAGATCAAGATCTGGTCCTTCATCCATGGGTCCACCAGGCTTATTGAAGCCACCTCGCTCTCCAGCGN
+
CCCFFFFEHHHHGJJJJJJJJJJJJJJHHJIJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJGJJJJJJJHHHHHFFFFFFEEDEEDDDDDDDDDDDDD#
@5R8
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJIHJIIJJIJJIHIJJJJJJJJJJJJJJJJHHHFFFFFFFEEEEEDDBDDDDDDDDCDDDDCDD#
@5R9
TATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAG
+
C@@FFFFDHHHHGIJGHIIIJEHIGCHGGIIJJIJIJJGEGHHIJJIJIGIGIIIGIJJJJJJJJJJGJJIJJJIIGIIEGGHHHHEFFEFEEDEC
@5RA
ACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJIIJIJJ?FGGIIJJIGJJJJJJJJJHHHHFFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDCDEDD#
@5RB
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
B@BFFFDFHHHHHGGIJGHJJJJIGGIGDHGHIIJJJJJJIJJJJJJJJJJJIHHHHHHFFFFFEECDEEDDCDCDDEDDDDCDDCDDBDDDDDDDDDD:#
@5RC
CTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGN
+
CCCFFFFFHHHHHJJIJJJJJJJJJJGGGHIIIEIIHIIGGGIJIIJJIGGIIIJJDHHIIIHIJJJJGGGGCHDHH>EEFDDDDDDDDDDCDCDDDDD>#
@5RD
GTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGGGGCTGTCCATAAGAAGTTGN
+
@@@DDDDDF?DFAGH:2ABF@HFHIIIDGGAGHD7@GEGGHC?FDHEBCDAC@F5@67++3:(34(:4>(4@>3@@CCCB&9-&05?CCCAC(+449:3@#
@5RE
TGCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCN
+
CCCFFFFFHHHHHIJJJJIGIJJJIJIJJIIJJJIIEIIIJJJJIIJIIIJIIJIHIJJJJJIJJJJJIJIJJJIIGJJJJJFHHHHHEFFFFEDEDCBD#
@5RF
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
CC@FFFDFHHHHHJJGJJJJJJJIJJJFHGJIIIJGIJGBFIJJDHIGGHJIIJIIJIIH?CCHHFFFDEFEEED>CCDBDBBCDDDDDDCC@CDDDDDD#
@5RG
GTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTN
+
@@@D?DDAB?DFA?FBFFF@HIDHBEEFEHGEFED??BGBBGHHHIG(B=@EH;@E7AEHE@@D@CCCCCCC>>@B=@BB8@CCA@CCCCB0<?BC@AC@#
@5RH
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHIHIJIJGIIJFIGGIJJJJJJJIIIJJJJIGJJJJGGIHJIJHHDFFFFECDECDDDCDBCDCDEDFDDCCCCDCCDDDCDCCDD
@5RI
CCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGGN
+
=:=1+2A+ADD;D3<?EEB>4AC<E?<2<CB<<:*?BEEB<1:1?*:?<**0?9?@2B8?)8=CC:8=7(7@)=AA3559<'=.-5>5>AA=(,52'89;#
@5RJ
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
???:B,=B3?DDDAE:AE@;BF?+A?EEDECDEIDDDI9DE*?B<B*0B8B@4BBC@CE>@;=8=A6/;=(77?AA@AA@(;55;>?55,,,:??((28
@5RK
CTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTN
+
@CCFFFFDHHHHHJJJJJJJJJJJJJJJJJIIJJJJJJIJJJGGHIIJJFHIGIGIJIIJIIIIIGHEHHGHHEHGHFFFFF@ACEEEDDBDBDDBDDD5#
@5RL
GGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGN
+
@C@FFFFFHHHHHIIIIJJIIHIIJIIJJJIIIIJJGJJJIIJJJJJJIJJJJJJJJJJIJHFFEFFEEDDDDDDDDDDDDDDCDEEDDDDDCDDDDBDB#
@5RM
CCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGN
+
C@CFFDFFHGHGFGGHIJJ@AHGGIJIBIGGGEHIIJJJJIIIHHHIJHGGIEC?EFEDFDCCDDDCCDDDCBCDDCDCBBCDDDD@CDBD?CACC@CCD#
@5RN
CTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJIJJJJJJHIJJJIJJJJJJJHHHHHFFFDDEEECD
@5RO
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
@@CDDDDBFHGFHGIIGEHJIIEHGIJIJJIJJFEFIJJE@GGIGJJGHIIGEFGGEIGGEGGHGHGGFFED@CA@AEDDDDDAA5>AABDD-<@D>CC>#
@5RP
ATGACATGTGGGTGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGAGGCGTTCTCTTTCAGCATCTTCACGGCC
+
CCCDDDFFCFFF<EBHGEECHIIIIIIIIIGHIGGGGIFGIIIIIGIIGIIFFEHIIIHHHHFFFFFDDB@BDDDDDB@ACDDC@CCDDDCDEEDDBDB
@5RQ
GGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
BCCDFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJIJJJJIJIIJJIJJJJHHEHGFFFFFEDAEEDDDDDDDDDEDDDD)9BD9CDD#
@5RR
AAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTN
+
<;?DD32BB:2C:<<ABBE+C?CF<C<CEC@F3:?E9C??9?0::0?4?DD??DB?DDI'-;A:;;@?AD@AA@@A?>995:AA<<:53(:>AAAAAA++#
@5RS
CATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGN
+
@@@F??BDD?HDBG>BEEGDDDHHIIIHGF9EBGHIBH@DHCHGFGCGGIIHAFHGHHIBF<FAADGGCCGGGFEEH?BDFCAAA>(5>A;-;:>>ACCC#
@5RT
GGTTGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGN
+
@@@DFFFFDFHHHJIIJJJJJGIDIIIJJJJGHIIHIIIJJFHIHIJJGGHJJJJIIIJJHHGFFFDD;ACDDEDDDDB?BDDDCDCDDDDDDDDDBDDD#
@5RU
CAGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTN
+
??@;D?DD?D>BD=:<CCC@=;F@;FFFBDH<::B?FDD@?GDFA<BFGE@BG8=BGDD@:;4C7@?A>C?BC>)73,5/(,5>;>CC9A@CCA:@A@CB#
@5RV
CCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGGGGTAGGCAGAGGTGGTGN
+
8=?BD@DBFFA:@:EEAGADGIB?DEBFBB;;;BFFCA@)=C@=CFE>E>AB?B@<B?=;5;A>>B@59<@>>?>528<BBB&05>9?@ABB88<B<?08#
@5RW
GCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCN
+
CCCFFFFDHHHHGJJGIJJIIHIIIJGGIHIJFGJJIJFHHHIIIJIIIIJIIIIIGHIGHIIEHGGHGIIIHCHHFFEFDCECDDDCDBCCCDDDCCCD#
@5RX
CAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAA
+
CCCFFFFFHHHHHJJJJJJJJJJHHIJJJJIJJGIIIJIJJJJJJJJIJJJJJJJJJJJJJJIIJJJJJJJIIJJHHHHHFFFFFFEEEDEDEDDDDDD
@5RY
TCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGN
+
CCCFFFFFHHHHHGHJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJIIIIJJJIIEIIIJHHHHHHFFFFFFEEEDEDDDDDDDDCCCDDDDDDD#
@5RZ
CCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGN
+
@@CFFFFFFHGDFGHIJIIJJIGHIJJIIGHJJJIJIGJIGGIJGIIIJJJJEHIHHHHGFFFFFEDCEEDDDDDDDDDDDDDCDDDDD0<>5@CC@ACD#
@5S0
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
C@@DFDADDHHGHIIGGHJGJJGIIEHHJIHIIEHEHEGIJF:DFI@FHIGGGHEGGGGEDD@BEECEDDDDDCDCCCDDCCC?CDDCDDDCCEDDCDDD#
@5S1
GGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAA
+
CCCFFDDADAHFHGIGEGHGGEEGEGFHEDHIFHGH0??GIIGGBHE@AEGGGG@AHH@EBFD>;?BB@BBDDDAA@BB?AA2<39@AAC??A??ACCC
@5S2
CGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTN
+
@@<DFFFFHFFFHGHEGIIIIFIEHAEHEEHIIICBHGGHEDHIIBBHIGCHGIIIFGFFFCECBC=CADCCCCCAC@58A@BBB9@ACCCACCCCCCCC#
@5S3
CTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACN
+
@@@DD>;BCFB?C<A?BBAF?CE4AEBEA?CFFHII;FH?CFBEHII@<FEHBFHG-;@;:>CEDEC;@;2?A??=;<CCCBBCC(5>CCCCCCCCC<AC#
@5S4
CAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGN
+
@@@DFFFFHFHBDG=EBHHIIGHBEFHDHDFGGCGHIIFIIDDBDDDCCDCCCCDDDEEDCC?CDDDAD>BDD?CCCCDCCCDDDCDACEDCC@>>9@DD#
@5S5
GCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
@@@DFFDEHHHHHJEGIJHIJIIJGGCHIJGGGCCFGEHGGBBFIHIGHJI6;AE;CCEHCHHHFB??CBA?B>AABDDDCDCCCCDDC@A<?CACAC
@5S6
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATN
+
BBCFFFFFHHGHHJJJJJJJGIHIJFHIJDGFGIFIJIJJJIIIJJJJIGIJIJJHJIJJJHHGHFFFFFDDDEDD;A>CCDDDEDDCCBDDCCCDDDDD#
@5S7
TTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTTN
+
@CCFFFFFHFDHGJGCEHIIIIGJJIIJIJJIIGIJIJJJIJJJJIIJIJJJJBFGHHGIIJIJGCHIIG@FHJJIJJJGIGGGEHEEHFCFFDFFFEEE#
@5S8
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
@@@FFFFFHGHCFHIIIJJGHIIJIIIJJIJJJJJJIJJIJDGIJJJIIIIJIIGGHIJJJIGGIGIJIIHCHF?BDDCCEEDEDCDDDCDC;@BDDCBD#
@5S9
CGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGN
+
CCCFFFFFHHHHHIIJJJJDGCGCHHGFHIIGHIGGHIHIGIEHBGGGHJGIJIHGHCHGGEIEHHGHDEGIIHEHGHFFFDDDDDDCC@CDC?CA@DCC#
@5SA
GCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJHJJJJJJJJJJIJIJJJFGIHEHHFFFFFFEDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@5SB
ATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTTCTTCTTGGAAGGACTCTGCCCATCCG
+
=@<BD4+:<=4ADFFB?BFH<<<AEB+:A2CFFI<F9:EFFF<EGGF4:BFFF:0()(/./8=B=;@E:<).(.6;36;>@B@5<@2(::AA5953+<0
@5SC
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
CCCFFFFFGHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJIJJJJHHBDDD@DDDEDDDDDDDDDDDDDDDDDDDD#
@5SD
GTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTN
+
@@@DD>B?CFD>FBCE:<C@EG9B@GGDDHCFGFFFFEFEA<CFEA6B18?9/BFGB<FFICFF@DF7;CECE:5,=@A>AC;?@;?B>>:3@?38.0&8#
@5SE
GAGATACCTGGTTTATAACCTTCCCAGACCCTCTCCTCTCCACACCCAAGGGTCCCGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTN
+
?=@DFDDDBDDFFGBFGEDHGIIGIEAACBCDHHB@FFHB?BFHGBDBGDE;8=BGBH6:5??;;BB?>>>;;5;>;>@>:;;AAC95<:A?B>AB>><>#
@5SF
TGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGC
+
CC@FFDFFGFHFHFHGJJJIJIIJIJIGIIJIJIGGGHGGIJIIJJJ9BG@DEHBHBHGIJIJFIIEHCEHEFEBED7=C?BD5;B8??)8CCCD4>CA
@5SG
GTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACA
+
BC@FDFFFGHHHHJJJJJJIJJGIJJGHHGGGIIIIJJJJJIJJIJJJIIJIIJIDHGJGGIGIJIJJJJJHEHFHEFDEFFFCEEEEEDDDDDEACCD
@5SH
CGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTN
+
CCCFFFFFHHGHHJJJJIIFHIIJJIJJJJJJIJJIIJJJIJJIJJIJJJJJIJJJJJJJIIJJJIIJJJIJIJIJJJJJJHHHHFDEEEEEEDCABDDD#
@5SI
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
@@?DDDDDFFD;D@GFFF@FG+ACGE<EE?EFFFDEEGFG9BFDFI@8BDFEIEFICGII@77761AEEDDBBDD@(;3@B@B38?B>,5:>(:(::(:?#
@5SJ
GCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACC
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJHJJJJJJJJJJJJJJJJJJJIIJJJJJJHHHHFFFFFFEEEEEEDDDEFEEDDEEDDEFDDDCDDDDD
@5SK
CTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCN
+
BCCFFFFFHHHHHHIJJJJJHGIJGIJJJJJHIJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEDEDEDDDDDDDDDDDDFDDDDDDDDDDDDDDD#
@5SL
GGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCN
+
@@@DFFDFDDHHHJGGHJIJIJIIIIGIIIJJJIJJGIIJJJIJ?DDHHHHHIIJGIIJJIJIJIGDGGEEFHFFFDBDDCDDDDDDDDEACCDDDDDCC#
@5SM
CCCCACTTTGCGGCTCTCGCGGAGGAAGCCCCGCAGGGAGCCGTATTTGGCGTACTCCACGATGAGGAGGAGCGGGCCATCCTGGCTGCAGGCCCCATACN
+
@@@DFFFFHHHFHIIIIGAGAGEHGIIEIGEGIDHFFDDDDBD8@DDEDDC?<BDDCDDDD;ADC@?CBDDDDBBDB<BCDDACAADB@CDABDDDD?>?#
@5SN
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJIJJJJHIIJJJIHJHIJJIJIJJJJHAEHHGFFFFFFEEEEEEDDBDDDDDDEDDDDDDDDEDDDD#
@5SO
TGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGN
+
CCCFFFFFGGHHGJJJJGIIIJJJJJJJJJJJJJIJIJIJJIIJJJI@FHIJHBCDEEDDDDDDDDDDDDDDDDDDDDEEDDDDC@CDDDDDEDDDDDCD#
@5SP
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
BC@DFFFFHHHHFIEHIGGIEHIJJJJIJIIIJJJHIIJJJJJJIJJJJHJJJIJJJJJIJJJJJJGGHHHFDDDDDCCDDCDACDDEDEEDDDD>CDD
@5SQ
CAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGN
+
CCCFFFFFHHHHHGGIJFHIJJIJJJJJHIIJJJJJJIJJIJJJJGHIJJJHGHGFEFCEEEEDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEED#
@5SR
GTCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCN
+
<@@DDDDDFHH?<<:CDDEDEGG@HEHHCGGBHGB?9CDBFDEDC@DB?DFB@FGD@FDB?DD@B8CHF7C@=)=@@(=;EEBC?;)9;=98;>;;@CA>#
@5SS
CTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTN
+
@@CFFFDFFFFD>FHGGHFFGGIJHGHIJGJIGIHHJJJIHIGHCHCFEGHJJIHHIJIGIHIHGIGGGGIGIGIIGHIIEHCFFHB@DFFEEEEDEEAC#
@5ST
CGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTN
+
??@DDDFDFDHGFGHIGH@GGIHIHHGHAGHGGD@>;;@FGAEHAGHBA;@;;C76AE<BBCAE?CD;5>@@CCC>A?1<<7@>D<@>CC:CCCCDCCAC#
@5SU
GTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTA
+
CCCFFFFFFHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJHHFFFEEEEEDDD@CCDDEDDDDDDDDDD
@5SV
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGN
+
BBCFBDDFHHHHHJJHJJJJJJJJJJJIJJIJJJJJJJIIJJIJJJIGIJIJJJJJJHHHHHHFFEFFFFCEEEECDDDDDDDDDDDDDDCCDDDDDDDD#
@5SW
GTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGGAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGN
+
BBBFFDDDHHHHDIIIJJJIGFDDDDDDDDD7@BDDD&69BDDDECDDBD5:BDD8BDD<ACDD>ADECEDDDDDDDDB@BDDDCABCDDDDDDDDDD3@#
@5SX
TTCAGCACCCCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGN
+
?@@D=;AD?FDDDAACEAAHF:9F?<AHFF@CB???:FGBFF??499BBDFCEFIIFFCC@FCGIIAF@===@=@EEEEFFCBDBDDBCC=;;A:>@B>B#
@5SY
GTTTCATGCTCATATCCGGTCCCGGCAATGCAGATGCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACG
+
@@@DD;DD?<FFHG@FEHIHAA8FEFH@GEGGDG?D@BG<DGCDGAA;7=C>6AA==A=@>;5;;=BC=B@@A@AA><?<<?A@AA@B59BCC>@@@?>
@5SZ
CTCCCTTTCTATAGTAGCTCGCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTN
+
@@@DFFFFGFFHHIFHJJJIHGGHIGIIJEGGIIG<?DHIJEGHGIIIGIFFE@;CA=EA=??;?BDEEC@CCECD>1;<@?BBC@B::ACA:ABB@<9:#
@5T0
GCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
;?@DDBDDF?@DF8AGBFDACFFE@FF91:D8?BFGGE@CFGFCFFFDEFFEEEAEADA=;DDC?EBD:;@?;;@AABAB@BB?<9@93::@3<+9(:@:#
@5T1
GTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAA
+
CCCFFFFFHFHHGJIHIGHIJIGGHFHIIFHGIJJJIGIJJ@G@FGFFEIJJJJJBBB-:BDEFD.3;>CCCDFEEDEDDDCDDDDDDDDDCCCC?CC
@5T2
CTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCT
+
CCCFFFFFHHHHHIJJIHIJJJJJJIJJJJJJIJJJJIIHBFEIJHHGHIIJIIJJJJHHHHHHFFFFFEFDCDDDDDDDDDDEEDDDDDDDDDCDDDD
@5T3
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTCCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
CCCFFFFFGFFHHJ<EHFHIJHHGIJIJIJJIJHJFGIIIJJJIGFH@BEHHFFDFFC@DCCEEDDDDDCBDDDDDDDCCDDADCDCDD:@CDDDDEEED#
@5T4
AGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCN
+
@@@FFFFFHGGHHJJJJJJJJJJJJIJJJJJJIJJJJIJJJJJJHIIIJIIIIHHHHFFFFFEEEEDDDDDDDDDDDDDCDDDDDDDDDDDDDDDCCDDD#
@5T5
ATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTN
+
@@@DFFFFHGHHHJIGJJJICGGHJJICGIIJJ4CEHIHIGIGIIIIGGIJJIIGJIJIIIGIGIIFJIIIJGIJIIGG@GIGIJJJJIGCHHGEFFFEF#
@5T6
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJBGHJIHJJJJJGIJJJHHFFFFEEEEDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDD#
@5T7
AGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTN
+
B@@FFFFEHGHHGJJJJJJJJJJJFGHHIJGBGHIJJJJIJGIIGFFIJJJJIIIIHBCDEECDDDDD@DDDDDDBDDDDDDDDDDCDDDDDDDDDDEDC#
@5T8
CTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATA
+
@CCFDFAEDFHHHEHJIGGGAHIIHGIIIGIIIGHGFHIIIIJJIIJJJIGHIGIHIJJIIBDHHJAGGGGGGG>AEE@CCC>?CAEECCDDCDDDD
@5T9
GGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAA
+
BC@FFFFFHHCDHIJJJJJJJJJJJJJJIIJJJJJJJIJJIJJJJJJJJJJJJJJIJJIJJJJHHHHHGFFFFFEEEEEDDDDDDDDDDDDDDDDDDDD
@5TA
GGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGT
+
@?@DDD?D<@ACAB@BBEHI?ACFEFEGEFGF?BF?FFFII@ACAFCBCAEEFIIFIICFCCEAFEDDD>=;?BBDDB>@ABB=8395><BBBBB+9@:
@5TB
CAAGACTTAAGAAATAAGAGCAGATGCTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGA
+
@CCDFDEFHHFGHHIGGHIJIIIIEHIGEEHIJIJJIJDGGIIJJIJBCCHFHIIIJGIJGHCGIICHIIIGIGHFBFDFB>CCDD;?BBDDDDDDDD
@5TC
GTGGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTN
+
?@<A:DDFGHHHHIJJIGIJIJIJEBHIJJJJIJGIJIIIJGGHGGHEGIGHIIJJGDCHHHFFFFF@CECECDDDDDDDDDDDCDCCCCCDDDECCDBC#
@5TD
CTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCN
+
CC@FFFFFHHFHDGIHGIGGHIGFFGIIJGJGGEGEGG@FFAHFGHEDDBBDHI9BFFHIJ=8@FH@=@CDEFHHF>>@BBDDFDCAEC@@AC@CDC>BB#
@5TE
CCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJIJJIJJJJJJI@FHIJHHFFFFFEEDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD09<BD#
@5TF
CTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHHHHHJJHJJJJJJJJJJ+AGHJJJJJJIJJIJJJJJDGHJJIDFDEEEDDDDDDDDDDDDDDDDDDDEEDDDDDDDDDDDDEDDDDDAC
@5TG
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
C@@FDFDBDHDHHCBFHIIGGHEGIGFHHHIIIIIIGGGEIHIDHIIIIIIBHIIIIDIGGIIIIH8AEACC@EHEFFDFFFEDEEE@CBDDDD@BBDD<#
@5TH
CACAGGACCTCCTTCCCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTTCCAGGGGCACAATGGGGACCAGTTGAGCAACTGGTGGTGGAGGCTGAGGCN
+
@?@DB?DBB?FFAHDEHBFA?:8C@GDCHI?BFCB?FHCD?BBFA=@CDF;77==@<=<B;AA@@>=;355<CC>;:ACC539>+9<028?B?<?<<<?7#
@5TI
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
BCCFDDFFHHHHHJJJGIJIIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIGGIGIJIGIIJJHHEEFFFFFEDEEEEDDDDEEDDCDCCDEEEDDDD#
@5TJ
CTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTCCATGATGTCAACATACTCCTTCACAGCTTCTGGTGGGATCTCCTTGN
+
@@@DDDADHB?D<CG?<E?A<+<C?CCAFC?EF;*1:?119?:??:DGCHIE@BF@F=FICHCGGHIE@>@73?CA>@>DDC6(>6;.,,'9>,5:5@:5#
@5TK
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGN
+
@@@DDDAD@FFDDGI@FHHGGEH<>GECEDGCGHIIGIFCHDGGGIIIDGGGGCDHEHHHHFHE@DEDDD>>CCC>>=@BBB@CCCCC@CCCCB@C>ACC#
@5TL
GGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTN
+
@@BDDFFFHHGHHJJJJJGIIHIJJJJGIJIHJIIHHIGIGIIJHIIJJJJJ)=EHHGHFFFFFFFEEECEEDDDDDDDDDDEDDB?CDDDEDDDD?@CD#
@5TM
GTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGA
+
@BCFDDFFHGHHHJJJJJIJIIJIJEHJJFGHIJIJJJJJJJIJJFHJJIJJJJHHHHFFFFFFDDDDDDDDDDDDDDDDEDDDDDDDDBDDDDDDDDB
@5TN
CTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCN
+
CCCFFFFFFHGHHIJIGHHGIIGIIIIIIIIIIIJJIIFHIIIIIJJJJJHIIIJJJIJCGGIIEHIJGHHFFDCB)9@CDDCDDDDDDDB:ACC@BCCC#
@5TO
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
CCCFFFFFHHHHHJJJJJJJHIJJGHIJIIIIJIIJJJJJJIJIJJJJJJJJJJGJJIIJHHHHFFFCCCEEDEDEDEDDDDDCDDDDDDDDDDCDD@DC#
@5TP
CCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCN
+
<?@DBDDDH<FHFBHEH@CGGII>GHIE@CEEBDB>@FHGEGBFGI@A=@5@F@=@GA=CACCEEEE@BB?CD>CDAC59?C:>A@CCAACC44::>4>>#
@5TQ
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@@@DDDFDHGHGHCGHIGHIDFHIGIEGIIGBHGGFHGIIIIIDDHGGEGGGHHIGIGHIIGIIIIIIIIIII7=B=?CC@CEEEEDDEDCCCC@CDDDD#
@5TR
TCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGN
+
C@CFFBDDHHGG8CGHCGGGIBGCDFGBBGEGGG<DHDGDCCC@FAGGGHDDHEH>>EEEDBDBCC@>CCECCCCCDCCCC>>:@@BBBBBCCCCCCC3>#
@5TS
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@@@DFDDDHHGFHIGIJJJJIJJJJEGJJJCHBFCHI@FHIHDGGIJJJGJJJGGJIIJJJFIII@DEH;?EDFFFFFFDDD9=BB8>CDDCDACDD?BD#
@5TT
GGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
?@@4AA?DBF?CA<@FHIEHEEG>FGHEBBHHCGHGE<FGHGIIGC9:DFFBG;FFHIIECDB.;E47)7.7AA=?EBBDBE?C.;?;??B?<9=3<B@
@5TU
CCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJCGGIJJHHHHHHHFFFFFFFEEEEEEEEEEFEEDDD#
@5TV
GTCCCCATCGCCGCACACTCCATAGAACTTGACAATGTGCTCATGCTGCAGGTTGGTGAGCAGCTTGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGN
+
?:=;BDB??1DC@@G:C?B?FFDDD<?DGDD>GFHHGBDFDFA?FHECHDGA@DGH;C?E>?@@D?7=;6;>=?A??C@>AC:@C@AC?>@>5<@0<B@B#
@5TW
AATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTN
+
CCCFFFFFHHHHHGIIGHIIIIJJJIIIIJJJJJJJJJIHFHIJHIJIJGIIGIGHIGHJCHJJJJJGHJJJJJIJGIJJJIIJHHHHHEHFFFFFFDCE#
@5TX
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
CCCFFFFFHHFHHJJJIJJJJJJJJGHIJJIJJ?FHIIIJJJJIBGHIJFHJJJJJJJJHHHHHFF>ACECEDDDDD@CDDDDDDDDDDDDDDDDDDEED#
@5TY
CTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTC
+
CCCFFFFFHGHHHJJIJJJJJJIIJJJJJJJJJJJJJJHIJIJJJJJJJJJJIJIJJHIJJJJIJJJJIJJHHHHHFFFFEEEEECDCCDEDDDDDDDD
@5TZ
CTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTN
+
CCCFFF@DHFHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJHHHHHHFFFFFFEEEEEDDDDDDDDDDDDDDDDDDEDDDD9@DD>#
@5U0
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@@@FFFDDFFFHHJJGIJIIGHGHIIGHIFGEFCGCHFHGGDGCEBIGGIFIE<>=FHHGJJG@D@@EHAHHDFFDDFFDDD,8?B=ADDEDA4:A@??@#
@5U1
CCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGN
+
CCCFFFFFFHHHHJJJJJJJJJFHIJJJJJJJJIJJHHHHFFFFFEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD<BDDDDDDD#
@5U2
GTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTAACCTGCCGN
+
@@CFFFFFHHHHHJJJJHIJJIIJJJJJIJJJJJJJJJIJJIIJJJJJIJJCHIIJJIIIIJHHHHHHH@EFFFFFCEDEEEEDEDDDADDEDDDDDDDD#
@5U3
ACCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
CCCFFFFFHHHHGJJJIJJJFGHIJJJJJIJJJJJJJJJIJJJIGHIGIJJJIJGHHHFFDDDCCCDCCDDCDDDDDDDDBDDDDDCCDDDDDDDCCDCD#
@5U4
GCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTN
+
C@@FFFDDHHDFDHIJGHGECHHHJJIGIJJJIIEGEGIICFHJGGDDHIJIEGGGJIIGHHIJIJH59>A?CC@AC@;ABDBDD@ADDDDCDDC>A@CC#
@5U5
CTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCA
+
CCCFFFDDHHFDHIGGGIEIGGIFFHFAFHBHEFHHHIGDFHII;FHICFHGIFEGEFFBFCGAFGEHGHEEGHIGHA;6AHHFH
@5U6
GGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAA
+
CC@FFFFFHHFHHJJJJJIJJJJJJJJJDGHJJJJJJJJJIJJIJJJJJIJJJJJJIJJJJJJHHGHHHFFFFFEEEEEDDDDDDDDDDDDDDDDDDDD
@5U7
GGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGN
+
BCCFFFFFHHHHHIIHGGHIIHHHIIJGHJ?FFHIIHIIGIJGGGHGGIJIJJIJJJJIJGHIIIIHHFFDEFFE@CCEEEDDDD(;5@CCDDDDDDDDD#
@5U8
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTCCTGGGTGGTCTGTGCATATCCTTGAGTGN
+
CCCFFFFFGGGHHIIIIJIIIGIGHHIJIBHIJGHHGIJJIIGHGGEGIJJJIIIJICHHDGJIGFHIHI@C;DHHHABDACEEECCDDDDDDCCCCCDD#
@5U9
TCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGA
+
@@@DDDDDCFAFA?DEBFHDFFG3CBH8??:::?1:??0*?FGGE9BF?DBGGG.;A6.76..@A.7=A>@D?3;=;@@B1=8'54:@>@::@4:@@AC
@5UA
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
B@CDFFFFGGHFHJIIJJIJJJJJJJJIJJJJGIIIIHIJJGHIJJHJIJIJJJJJJJJJIJHHHHFFFFFFEDEEEDDDDDCDDDDDCACDCDDDED
@5UB
GAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCTTTATCTTTTTCATTTTCCATATATTCACGAACCTGATCCACATGAGTTGAATAAACCAG
+
CCCFFFFFHHHHGIJJJIJJJJJJIIJIIJJIJIHGGHJJJJJIIJJJIJJJJIJJJJJIIJJIIIIGIIIJJFHHHHHFEDEFEDEEEDEDDDDDD
@5UC
CCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGG
+
CCCFFFDDHHFDDHBEGGCHBCHIIHDEFDGIIIGEIIGDFD@D1DGGHGGBDGHCIIGGFFCE@DFDD>CD@CDACDC<B=@BDDDBACDCCDECDDD
@5UD
GTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGN
+
CCCFFFFFHHHHHJJJJJJJJJJIIJJJJJJJJJJJJIGIJJJJJJJJJJJJIJJJJJHIIHHHHHHFFFFFFEEEEEDDDDDBDDDDDDDDDEDDDDDD#
@5UE
CTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJGHIIJJJJJJJJJJJJJFIHIIJJIJJIJHGGHHHFDFDDEEEDDDDDCBDFEDDDCDDD#
@5UF
CCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCN
+
CC@DFDD:FCC?DHDDCCHICGIGIHH<CCBDDGGIDHG5@@AHEGEEFF>??CECD;;AEEBCBBBC?A>CABCCCCADC:@CCC>@CACCB2?9<C>B#
@5UG
ATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCN
+
@@BFFFFFHHHHGGHIGHJIIIIJJJJGIJJJIEHIJIJIIJIGIFIIJJIJGIJGGIJJIIIJJIJJJIJIHHHHFDFFFEDE@C;CDDDDCDDEEDDD#
@5UH
CACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACN
+
@<=DB;BDDBFBHBC@EBGGHEEHI==GBEGH8@FB>??BC77C;FGG@AA>EIHE5==@CCCCACCCAABB:@@?:ACC@CCCCBC>A4@AA<C?CCCC#
@5UI
CGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATCATCGAGACTGCCGGCGAAACCGTCCATCTN
+
CCCFF?DDDHDDHHJCGGIJIIIIJIIGGEHDHGEHIGIIJJFIGIHII<>DEHGIHIGFGIJIIFGGHGHDBDEF;ACECCCDDDDDDBB?B?@@DECD#
@5UJ
CTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATN
+
@@@DDEDDHGHHHIJJIJGIGIIFGHIEIIIIIJJIJGIIJHIIGGIFIGHGGGGGHIIJJIIAGHIJIJJJIFHHH@EDFFFFFFEC?CCEEDDDCCED#
@5UK
CTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTTGCTGGGGTATGGCATATATCCAAGAGAAAAGATTTCCCATAGCAGCACTCCAAAGGACC
+
?<=BDDDD8=CFDEH@?F?AFHEFHIEBAA@3:EFFFH@GDBGGCA6?F<FDBGIAHBGCE7.===@7C=ACEHDB;@@@C:;CCBB@A>55?@9?B@9
@5UL
GGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTTGN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@5UM
CTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTN
+
@CCFADDDBHHHHGIGGIJIEFHGGIIEIIIJIJIJIGIJIJJBEHFHGIJIGHIJHIGJJIIIJJJGJJJJIHFHHBDFFFDCECEDDDEDDDDDDCCD#
@5UN
GTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCN
+
@=@DFFFDHFFDDGHIJGGIJJJJJGJJHGGGGEHJJJIIEEFHHIGIJHIHGGIIAGHIHIIEGGAFGGDGHGIIHEHFHH@DFEFFFE>CEDEEDDDC#
@5UO
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGGGCAGTGGN
+
@@@DDDDDHFFHBAFGGGHI>GGE8CGGGGIBFHBDCGEE@GHGH@F8B>>CAGIHEGD@HEH@C;AEBDDECDDECCC;68>88=C@3:5>(5599?CC#
@5UP
GCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGN
+
?<@DDADDFFFF>4EAG<FAA@;G@<<FFCF>FDFFD=E:2B@B78AFDEEBA7@EF=?A>BBB;@7?>BC;25=B@?B;@?ABB@BBB>9<@9??B3>B#
@5UQ
GTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGN
+
?=@1DAADBF8C<:A<:EFF??B<EE<CE4CFBF@D8C9):B<49BDD?BDF8D1BF:F48=7=FG:8@EA.=@;?7=;7?=3?;B36;>(6;6@9;5==#
@5UR
TTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGN
+
@@??BAADF?CFFHHBEGHEEC?AE>ECEC<F?FEG:C<CF>F@)?GHIIIBB)52>::ABBC<?@CB::<?BBCCCCCCCCCCCCCCBBBB<BCC>3@C#
@5US
GTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATN
+
CCCFFFFFHHHHGIIJJIJJJJJJJJFHIJJJFHGGIJJJJHJJJJIIJIJJIIIIIJJJFHIJGHHIIJJ@CHHGHHDFF;@>CEEEEDDDDDDDDEDF#
@5UT
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCC
+
C@CFFFFFHHHHFE@GHIGIHIIJJJJJJIICGHHDFFGIFIGGDGGHHIHGIJIJIJJJJJIJJGIIGCHFFFACDBDCECDDDDDDDDDDDDCDDDD
@5UU
GACGTAGCCTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGN
+
@@CFDDEFFHHHHJJGIJJFBFEHGGIGIGFIGIIDHIGCFGHEHIJGEGIJIIIEIGIHGHHGEFFDFFDDD@>?@BBCDDCDD9@>CCDDCDBACDDD#
@5UV
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGN
+
CCCFFFFFHHHHGIJJJIJJJJJJJJJJJJJJJJJJJJIJJIJJJJJIHIJJJJJJIIGGJIIIIJHHHFFFFFFEFEDECDDD?BDDDDDDDACCDDCD#
@5UW
TTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTN
+
CCCFFF;DHHHHHJJGHIIJJJJJJJIIJJJJJIJJJJIJJJJJJJJJIIJJJJJJIIJGIGJJHHEEHHHFFFFFFFEDE@CDDDDDDDDDDDDDDDEE#
@5UX
GTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGN
+
CCCFFFFFHHHHHJJJJJJJGIJJJJJJJJJJHJJJIJDHIJJJHHFFFFFEEEDDDDDDDDBDDDDDDEEDDDDDDDDDDDDEDDDDDCDDDDDDCCDD#
@5UY
CCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGT
+
BCCFDFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJGHJJJJJJIJJJHIJIJJJIIHHHFFDDDDDDDDDDDEEDDDDDDDDDDD<CDDDDDDD@
@5UZ
GTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGN
+
CCCFFFFFHGHHHJJJJJJJJJIIIJJJJJJJJJIIJIIIJEHDFGHIHICHGGIJGGICGIIIIJHGFFEHFFFE@DD5>B=@B?BCACD@CCCCC4>C#
@5V0
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJDDDDDDDDDDCCDDEEEEDDDDCDDDDDDDDDDDDDEDDDDDDDDDDDE
@5V1
GTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGN
+
@@@FFDFFDDBBFEIGEFGGGJIGIIII?EGGHJDHBGHIIJIIJJBCGIJJHJJICHHHEEH>DDE@CFEEEEDDDDDDEEDCDCCB?CDCA<A>CDDC#
@5V2
ATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTN
+
@C@DFFDFHHHHHIIIJGIJJJGIIIIIJHJJJIJHFDDEEDDDDDDDEDFDD@BDDCDDDDABBDDDDDDDDCDDDDDCCDDDDDDDD@DDDDDDDDDD#
@5V3
GAGGAATAGCTGGCAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCN
+
@=?ADBDDF8??A+<CG+AFFACEF31CDFFF0??F@?@FBB>DBCFCC;FFII';;?A;ADDDD.6@A;;??>;=@BBBA:BB>@>ABBBBAABA@AAA#
@5V4
GTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGN
+
B@CFFDFDFHHHHJJJJJJJJFDDDBDDDDD:BDDDD9BBDEEDEDDDDDBDDDDD<BD?CDDDCDDECCDDEDDDDDDDDDDDDDDDDDDDDDDDDDCD#
@5V5
TTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIIJJHHHHHHFFFFEDDDDDD<CDDDDDDDDDDDD#
@5V6
CTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCACGATCCACCCTGCCTTCTCCTTGGGGN
+
?:=B1A0BCCB>DBE<CC333AE>F@EF3??4BA@FIE<D*:?D4*))?8B8?F:FCFF)=7));(=).57??B3,(2;;;>;;?9<<@B:A:>AB:389#
@5V7
GGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHEHFFFFFFEEDEEACDDEDDDDDDDEDED#
@5V8
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
???B=DB2=?D<DFCGIIEIHE<AGHABHFEFEGGIIFHGDA9?DDDHIECEIIGG>@BC@CBF>@@FEGGGGEA;E=?76(;?<9>@C@>C:@CCCDEC#
@5V9
ACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTC
+
@@CFDDFFGFDH?AACCGFFEFA>BHHIIGGHGHIICGGCHIGDBHHGEHIH?FAADDEHEEEEEEDFFFD:@CEEECCCCCCCCBBBA?BA@CCADCE
@5VA
CACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGC
+
@@@DD4A;C>DADFG@GE;EGBFBFF;?+::CD@=A1?D@;/5>:C?;@.;@;5;;@B9A82308?::@3::2>>>A@@44>:AC@@@((+:@CC(380
@5VB
CGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCN
+
CC@FFFFFHHHHDGGHBAEGIIHIJJIIGGGGJIIJJJJJJJIIJJJIJJJJIIJJJJJJIJJJIIIJJJGGHIJJGJJHHHGFHFFFFFDEDCEEDEDC#
@5VC
GTAGGGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
:1==BDDD>FFHBHGEGIIGFEGHIBGGGH@1C@9DGHEAF>GGICGGDGCGHIECHDEDED6CEE2.;@CED:>C>CC@2(55@CC>CC@C@CA>>?@@#
@5VD
ATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGN
+
CC@DFFFFHHHHHJIJIJHIJJJIJJJJJJJJJJJJJJJJJJJJJJIIJJJIJJJJJIJJHHHFFEEFFEEEEEEEDDDDDDDDDDDDDDDDCDDDDDDD#
@5VE
GGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGN
+
@CCFFF=DFHHHHJJJJJJJJJIJHIJJJGHIJJJFHHIJJFHHIJHIHEHIJGFHHHHHFFFDEFEC>CDDB@BDDDDDDD>BDDDDBDDD>AABDDDD#
@5VF
GCTCCATACATCACTCTCTGTAGTGAACTTCCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTGTAATA
+
CCCFFFFFHHHHHJJJJJJJIJJGJJJIJJJJJJEGHJJJJJJJJJJJJIIJJIIJJJJJJJJJJHHHHFFDDDDDDCCDDDDDDDDDDDDDDDDDEEE
@5VG
GTCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGTACATCTCCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGA
+
@CCFDDDDHHHDHJIIJIHIJHIIIJJJIJJIJIJJJDFHIJJAHIHIJGEHHHFCEFFECCDEEEDDDDDDDDD??808A@<@BDDDECDDDDDDCC
@5VH
CCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAA
+
@C@FFFFFHHHHHJJJIJJGHIJJJJJJIIJJJJJJIJJJJJJIJJJJJJJJIJJHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@5VI
GCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATN
+
+8=DDD:BB>?<C@B<EHGIIHIIG<HBGEHD<GEHI?*?GBB?D?@/B*?D<@FB@@9A@GI;CA';C;1?;.,9?@=?@CCCA:3>::@>@C:??&:4#
@5VJ
CAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCC
+
CC@FFFFFHHHDHJJJJJJJJFIIIIJJIGIJJJJGGIJJJJJIJJJJGECHHFDFFDEEDCDDDEDDDDDDDDDDDDDC@@B@BCBDDDDBBDDDACD
@5VK
GTCCTTTCCCAGGTGTGGGCTCTACAATAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTA
+
@@<BDDD?FHAFAHB:C;EFAHGEHDF@EGIGIDFGHGCHH@BFHHFII<DGIG@HIIFG;F=@FGCHICGIIIFEFEHHEEEEEDECCCBBBCCC@AC
@5VL
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFDFHHGHFGEHIJIGHIJFHIIGHIJDHHGFHGIGIIBFGGGCGIJIJJGGIIJJJHHHBDFFDCDDEED@CDDDDDDDDDDDDDDADDCDDCCD#
@5VM
GCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGN
+
@@@DFDDDHDFFHGGGGGHDHHIGHG?CDGHGGBFGH??DHGGGGIIIJAEHHGHHHFFFFFEEC@CEDDDDDDDDCDCCDC@CACDCDDEDDDDDCCCB#
@5VN
TGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTN
+
@C@FFDFDHHHHHJIJIGHEGIIJIJJGIHIGHIGGGHIIJJIJFHIJFHHIJAGDHIGFHFFFFCEEEEDDDDDDDDCCDDDDDDCCDDC>CCCE@CAA#
@5VO
CAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTN
+
CCCFFFFDFFHHHJJJIGGIJIIIJJJJJIJJJJJJJJJHHIJJJJJJJHJIIIJJJIJJJJJJIJJJJJJJJJJJFFFDDDDBDDCDACDDCDDDDDDD#
@5VP
TCTCTTCCAAGGCCATGAGTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTTCTTCTTGCTCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTTTN
+
?@7=:=BDDFBFFE;B?F><FFG@F?FE9C3CGEIFE@6?DEFFED?DF.8CEFII@=CFFC=D=@@>AA;A@BDDD@BBC3;?@BBB955>@BBABBBB#
@5VQ
CTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATN
+
;?=?+BA??<F:DFFFDFF:?ABFFEHE@EEFFIEEIFAG@6:;0?B9??7DFCA8)8=F7;CFEEEEEI:CAEEE33?;85537?;55@@:A(,<,5>>#
@5VR
AGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTCTGCTGCCCGT
+
=;+:D2AD?DDDDII;::C;FECE:AEBD8):)?9?<C*??D><3**0?49B/6;6;@7.@4@;@ECC9=C:A?A3;7??AA@A6(66-(;A5;5988
@5VS
CATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGN
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJJJJJJJJJJJIIIJJJJJJJJJJJJJJJJJHHHHFFFFFFDD>BD?CDDDDDDDDDDDDDDDDDDDDDDDDD#
@5VT
CGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACN
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJJGHJIJJJJIJJJJJJJJIJJJJJJJJIIJJIJIJJIBEHDFFABEEEDCFDDDCCCD>?B?CDDEEDDDDDD#
@5VU
GTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTN
+
@BCFFFFFHHHHHJJJJIJJJIJJJHJJJJIJHIIHJHIJJJJJJJJJIJJJJIIJJHIJJJJJJIJJJJIIIJJJJHHHHHHCEFFFFFECEEECEDCE#
@5VV
ATTTATTTTCCTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGN
+
CCCFFFFFHHHHHJJJIJIJJJJJJJJJJJJIJJIJIJJJJJJJJJJJJJJIJJGIJJJIJJJIJJJJIIIHHHHHHFFFDDDEDDDADDDD:=?BDDDD#
@5VW
CTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCN
+
CCCFFFFDHHHHHIJJJJJJJJJJJJJJJJJJIIJJJIIJIJJJJIJJJJIHIIIJIGGFHGIFGGHIIGFHFFHHHGFFFFFEFDEECEEECDDDDDAC#
@5VX
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJJGHIHJIJJJJJJIJHHJJJJJJJJJJJJJJJJJJJJJJJJJJJGIDHIIJJHHHHHFFFF@CEDACDD;?@BCDDDCDD<BC
@5VY
GCCCGCTCATTTCAAACAGGAGCCAATGGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGN
+
@C@FADDDAHHDFIIJIGEGHHDHJIJJGCFGHGIIBGIECHGHIJJGCGIDHCHGIIIGGIFHEIEHFHHH7ADDFFFEEEC(6;>CCDDDCCCACDDD#
@5VZ
GCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGGGCAGTGACTGGN
+
@@@FFFFEGCFDFHIIGIIIIIICFHIIIIIIIIIIIIIIIIIIIHIIIIIIHGHHGIHICHIIIIIII7AHHHHFF;@CDCCDDCBD'8>BDACCDDDD#
@5W0
GTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCN
+
CCCFFFFFHHHHHJJGJGJHJFHGHDIHAEGGIEHHCFGEHGHIJICHGCBFHFIJEA<D9BDDFFHIIBGI@FHFHEHGEHHGIE8ACHEFEFFFDDCC#
@5W1
GTTTGTAGTAGTGGCGCAGGGCTCTGGACATTTTCTCATAGGTCATGTTTGTTCTGTTCTTATGGTTTCCCCACAGTCGAGCCAGTCCGTTGGGATCCACN
+
CBCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJJJJJJJJJIIJJJJJIIJHHHHHFFFEEDDDDDDDDDDDDDDDDDDDDDD#
@5W2
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTAT
+
CCCFFFFDDDDDDDDDDCDDDDEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDCCDDCDCDDCCDDCDDDDDDD<CC
@5W3
CCGCCATGAGCTCCAGCAGGATGAACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTCGAATTTGCTGATGATCAGGGCN
+
CCCFFFFEHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHFFFDEEEEDDDDDDDDDDDDEEDDDDDBDDDDDDDDDDDDDDEEDEDDDD#
@5W4
ATTAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCN
+
@@;DDFDDDFBHHIIIIIIIFGBDGEIEHGDGDFBDDGFHIDDFHHHIDFHII@CEADAHHGFAHDEE;BECCCBBCCCCCCCCCC>C@C@ACCCCCCCC#
@5W5
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
@CCFDFBDFHFHGIJGGIIJHJJJJHGGIJJJ?@BHDFHHGJJ=FHGGIJJIGHGHGFFFFFEDECDDDDCDDACDCDDDDDDEDDDDDCDDCDDDECCC#
@5W6
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
B@@FFFFFGHGFGCDHHIIJJFIJIIIGHHCCGHGHJIJJJJIDFGHIIJIHIHGHFFHHGIJIGGGGEHIJGAEEDDFCEEBECED@CDCCDC:AB@BD#
@5W7
GTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCN
+
@@@DDDBDHA?DDFFGHIGHE@:AH8AGBCFGGIG?F@FAGGIGEGGHB0?@GH9C@@@;74@CCHHE?ACCCCBBBB?ACC@C:>@CCC@>C:A@C@@@#
@5W8
TGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACAC
+
BCBDFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHIJJJJJJJJJJJJJJJJIJHIJJJJJIJJJJJHHHHHHFFFFD
@5W9
CTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGCCCGCAAACACCGGCCTTTTGTCCGGCTCCTGAGATCGGACGAGCCCACGTCTGAACTTN
+
?@@D:B?8AD+<<:<2CGICC?@?BE9+<22AEF9C*?:C4*?:)?6@DFFE7:8@@=CEEED@758<'9=>@:(:>:9=?20590&(2+&+29(:@AA>#
@5WA
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
@@@DADDABDDFHBGICF<FH=FFGE?FAHFHHFGI<FB@0008?@DD-8B;FCHIIICDEHH?7;7?D@;;AA7AACBBB28?:;:ABCC?AACCACB?#
@5WB
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
BBBDFFFFHHHGHJJJJJJIIJJJJJJJJJFHIJJJJJJJJJIJGHIJJJJJJJJJJJJJJJJJJJHIIHHHFFFEEEDEEDDDDDDDDDCDDDACDD8
@5WC
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGTN
+
;;?DDDDDHDHF?FC@C9GH:???FBG>;FGHIIIG@GDFHIEGIIIGCCBFG?FGCFAFHGGICEHCAAEEHEEDBD?>C@:1;A(,;?,:>@>@C3::#
@5WD
CTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTN
+
@C@DDFFFGBHFHBGBBGFCH>:<?FGEHIIIGIFEIHIIIGHIIIIGEHIIIEHGG=C@FCCHAH:E@EHHHGEDD==;@@@@CCCC5?9>C@@@CCCC#
@5WE
GGGGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCACCAGGATGGAAA
+
@C<DF8ADHHGHHFIIIIIIIIIIIIIIIIIIIIIIIIIIFGGIIIIIIDHHHGFC@BB;@BCBCBBCCC@?BBCC>BB?CCCCCCCCCCCCCCCCCC
@5WF
CCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTN
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJIJJHHHFEDDEDDDDEEEDDE#
@5WG
CTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGN
+
@C@FFFFFGHHHHJJJJJJJJJJJJJJJIIHIIJJJJJGHJJJJJJJJIIIIJFDDDDDDDDEDDDDDDDEDDDD5<BDDDDDDEDDEDCCDDDDDDDDD#
@5WH
ACCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGTGAGTGCCCTGCTGCCGTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJJJJJJJBFHIJJJHFDDDDDDDDDDDDDDDDEEEDDDDDDDDDDDDDDDDDDDD#
@5WI
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATN
+
CCCFFFFFHHHHHJJJJJJJJJFGIHIIJJJJJIJJJJJJJJJJJJJJJJJJJHHHHFFFFFEEDEEEEDDDDDEEEEDDDDDDDDDDDDDDDDADDDDD#
@5WJ
CCCGTATGCCTGGGGGGTCTGTGCATATCCTTGAGAGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
???DDDDD4<AD?1)16)0<8A83>+(+83+3+>3(++&0800<=5:)))933+39>9A33(3>?2>A:49;&)0>((+(323>+>34((44>:+4:+>A#
@5WK
GCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTG
+
CCCFFFFFHHHHHJIJJJJIJJJJJJJJJJJJJJIJIIJJJIJJJJJJJJJJJIJJJIJJJJIJIJJJJJJJJJJJIJHHHHHHFFFFFFECEECDDDE
@5WL
TGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCN
+
?@;B?BB;CCADDGGDFEEGIIGI?FBDFEGE?DGDGIEGGHEGGIG;BDB>;>CCD>;@>>?BBBB?CDABBBB<CCC@:?AB?ACCBBCCCCCCB9AC#
@5WM
TTGACGTTTTTCTCTTTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCN
+
@C<DADDFGHHGGJJJIGJIJJIJDFBEEH<FGGCGGGIFEGH;;AHFF?DF>AB?BACCCDCDACDD:;CBBDDDACAB?CDBDCD?7>CBCAAC>35<#
@5WN
GGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACC
+
BC@FFFFFFHHHHJJJJJJJHHIHIJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGHHHHFFFFFFDDDDDDDDDDDDCD>CDDCDEEDD
@5WO
GCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCAAATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGCGGGGGAAAGCTTTGGCTGGCN
+
?+=?1DDDDDD4DE9C+2A1+:C19C?3<B3C9*:9*1****::4*0?DDB***999DCACC@;.==).74))..7=3?(3,))&&)(++(++:9(48;<#
@5WP
CTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGN
+
@@@DDDDDFDAB<F<DF:@EECFEBFCFHE<CDF1)?GC?F4B?0BBF9<DDF?DD;;6@;=C@ABE=>EFFFF;.?7?BDC>>B(;6>@BBBAB@<<@B#
@5WQ
GAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCN
+
B@@FFFFDFHHHHIIJJIJJIJJIJIIJGGIJJGGIGIJJJJJJJJJJJJJHIJGIIJJJGGGIJJIJJIHHHHHHHFFFF@DFDECCBBB@8ACDDDBD#
@5WR
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
@<@DDDDDFBFFHBEBEBCCAFHADACFF@>GHIIIIIIIBGCHHH><(8BCEEHFEDH(=????@DCB;?CCCCCCCBBB8;@CCCCBCC?>ACCCCBB#
@5WS
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
?;1DDDD;=?2;:AE@EBF><EE:C@+:?EE?CD>;D@D@@??DDCDDEDDD?.7@A4=?>DCD;??9=@??=(55>A<?>>>5>>:>AAAA4<?AAAAA#
@5WT
GGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCN
+
@@;DDFDFHAFFHIFGDGIIIIIIIIIIIIIGGGHIIIII@FDFGGIHIIIIIIIIIIEHIIHHHEEHFHFFFFFFFEEEEECDDDBDCBDCCBDDECDD#
@5WU
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
CCCFFFFFHHHHDGJJJJJJJIIIFIIIJIIIIJJIEHJIIJJIJJDHHIHIGGIIGHIIIJJ@EHFDEEEDED@CDDDDDDBDBDDDBDDDDDCDDDDD#
@5WV
CTCCACTGTTGTTTTGCTTCATCTCTGGACTTATAAATGCTATTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTGAATTCTATGAAAAGTAGGTCN
+
??;ADD4?2A<<AEEIIBEBFEDF<?:AF?F??C?91CB?CDD?D?DDEICDI@??8=B8B=C;CEIAEI;77735?A:77@DE>D;;6;>;;3--535;#
@5WW
TGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CC@FFFFFHGHHHJJIJJJIJJJJJJJDDDDCDDDDDCDCCDEEEDDDDCCDDBDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDCDB
@5WX
CAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCN
+
CCCFFFFDFHHHGJJJJJJIJJHIJIJJJIIJGIGGIJIGIIIIJJJJIHIFJGIJIJIIJIJJJIJJGGIIGEIJIGHGHHHHFCFDEFEEEDDBDDDD#
@5WY
CTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCCCTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
CCCDFDDDHDHGHJFBGIEEGDCHID>AFFGGDIIIIIJJGC?FAHGGG@HHGH)7CGGDHFH;C>47C)?=?EH@DF@DFEECA>@CCCCDCCCA(53
@5WZ
TGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCN
+
CCCFFFFFGGHHHJJJJJIJIIFGJJJGGJJJJJJHIIIJJJJJJFJJDHHIJGG;@AE:CHHHFF7@BEACCDDDDDDDDDDDDDCDDDDDDCDDDDDD#
@5X0
CAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATN
+
CCCFFFFFGHHHHJIIGBHIJJGIGHGHHJIJJJGGEFHHIIJIJJIJJJIJJJJJJGIJGIGJJHAHIJJJGHHFCABDD5@CDDECBBDDDDDDCBDD#
@5X1
GCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCT
+
@CCFFD?D??AFBCGHGII@ACICFHDD@EGE?F?<C?GHGGFBFABDB=BFGH@888?BBFBB2CF6C@@HIGEC?=AHCDDFB?C6>>>@DCA@AB;
@5X2
AGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGN
+
CCCFFFFAFHHHHJIJJIFHHIJHJJJJJJIJJJJJJJJJFFHGJJJJJJJEHIJJJJJHHFFFFFFEFEEDEECDDDDDDDEDDDEEDDDDDDDDDDDD#
@5X3
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCN
+
@C@FFFFFFFHHHJJJJJJJJJGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJJJCHHHEHFF5>BDCDDDDDD?BDDDDDDDDDDD#
@5X4
GTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTN
+
CCCFFDDFHGHHHGIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHEHHHHHHFFFFFFEEEEECEDEEEEDDDDDDDDEDDDD#
@5X5
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFDFHHHHHJJGJEGIJJJJJJJJJJJIIJIJJIIJJJJIJJJJJJJJJJJJJJJJHIHIHEHHHFFFFFFEECEEDCDDD8?@DCDDDDDD?AC
@5X6
ATCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CC@DFFFFFHBFDGHEBHIIIGIIIGIIGIGEHIJIIEEIJDHCIGIJIJGGIIJJIFHFEHHGFF>BBDDCDCCCDDDDDDDDDCDDDCDDCDDDDDDD#
@5X7
CTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGN
+
@BCFDFDFHGHGHGJJIJJIIIJIJJJJJIJJIIIGIIJJIG?FGGGHIIJJJJIIIJJIIJJDIIIHHHHFFFCB.;;@@ACCBDDCDDDCCEDDDDDD#
@5X8
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCN
+
@CCFDDDDDHHFHIIGHFHDFAHHEIIIB@@B@8>ACCD>AC@CCCDCACB@>?A8?B?BD?CDADCDDDDC@::>>:@CCC@>B@BCA@ACCCAADC9A#
@5X9
TGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGN
+
@C@FFFFFHHGHHJJJJIJAIHIIJJIJJIHIJJJJJJJJJJJJIIJJJJJJIJJJJJJJIJJJIJJJJJJJJJJJIIJJJJIHHHHHHGFFFFFFEEEE#
@5XA
TGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGN
+
@@@FFFFFHHHGHGIIIJJJJIJJJGIIJJJJJIJJGIJGD>?@@CDDCDDDDDCDDD:ACCBCCDCEEEDDDDDDCCDDDDDDDDDCAAC@BDCBCCDC#
@5XB
NGAACAAAAGCCTTTGTCCTGGCTCCTTCCTGATAATGTTTAGTTTGTAGTAGTGGCGCAGGGCTCTGGACATTTTCTCATAGGTCATGTTTGTTCTGTTN
+
#1:BBDDDBFCD?A>F@BE4CEC;E@;>@E@E<<<?>D49??F9?>D;?D49B*?D1@64@EF(.67?A;67;;>>66666;>A((53>(((:(5,(5(5#
@5XC
TTCATTTATTTTCCTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTACAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTN
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIJIJJJJIJJJJJJJHHHHFFFFFDDDDDDDDADDDD:=BDD#
@5XD
CTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTN
+
@C@DFFFFHHHHHIJJJIIJJIIGIJFEHFHHDFCDGGAHIIIIJIEGGJJDHDAHIIHFHIGGIEIGGBHEGDEHFHGHBBDFDBCDC@C@=BDDCDC:#
@5XE
CTGGTGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTG
+
CC@FFFDDBDHHHI@GHIIIIIIIGHIIIIDGHGGIIIGGIGGIIHHHHGGEFFFDBD??CCDDDBDBDDDCC+:?4>>ACDACDCDEDDDDCCDDDB
@5XF
TGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGN
+
@@@D=ADB?DFFDG?ACGACE8CHEHHIIGHEHIIECFHGIICHGEIIGIEHBHDHIIGGHCHGG@GGAEFHECBB@BC@>@C?>?A>@@CBCCC?:@>?#
@5XG
CCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTN
+
CCCFFFFFHHHHHJIJJJJJJJJIJJIJIIGJIGFHIIJIHJGHGHGIIJGHHFFDDDDDDDDDDBBDDDDDDDBBBBABDDEEEDDDDDDDDDDDDDA@#
@5XH
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
CCCFFEFFHHHHHJJJJJJJJJJJIJIJIJJHIIIJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJHHEFFEEEEECEDDDCDDDDDDDDDDCBDDDDDD#
@5XI
GGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTN
+
@C@FFFFFGHHHHJJJJJJIJIJIIHJJIIJGJJJJJJHIIIFGIHIJIJJJJJJFHJIIIGHIJJIIIHFHHGHDFFFFFEEEDABDBBBDDDDEEDDD#
@5XJ
CGCTCGGTTGCCCATAGGGGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGAAGGAGGGTAGGATGGAGGTGCN
+
8?@;DA:<8CAD?C:CGE31:?E?FCC<*BFAFFDA?D90?9B<DEB88=BCD;FFFI@A<A3.;B;7?>2;@CB;5?(;(((5338><B>>>B>+2++:#
@5XK
CTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAAAATGGACTTAAGCTATAGCTTN
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJIJHHHHHFFFFFEEEEEEEDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEEDDD#
@5XL
CAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGGAGCTGAAGGTGTAGTTCGGN
+
;;;BDD;3CD@DFBEGFIIC>BG???G<FFFID>108BDEF848BFFFF@;.@CFCCCFFECAEE;BDD;?7@@@B?BBB2?<?9?B:>>3>(:::>AB@#
@5XM
AGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGCAGTTACTCTGTCCATATCCN
+
CCCFFFFFGHHHDHIJIJJJCFHIJJJJJJJDGHIJHIJJJJIJJJIJJJJJJFGHIJJJHHHH@DFFFFEDDDDDDDDDDDDDDDDDDDDDDDDEDDDE#
@5XN
CTGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJIIJJJJJHHHHHFFFFDDEEDDDDDDDDD;@DBDDDDDDDDDDDDDDDD#
@5XO
TGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGGN
+
@@CDDDEFDHAHDHEHEHCDIHIGIGHIEIGIIHG?FE9CED<?D:?BFDBGFFH@B4??FDB@B/=BEFBCHGHIDEGCEEGECEHCED@;@.6>AAA@#
@5XP
GTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTN
+
@=?BDDDDFDHHBHAEHCA>HGGA?E@DGEEDGEGGG3B9?GFHIIFIIIGIGHEAAEHEHEEC?B@>CCCCCCCB@B;A5>@C@@AACABB@BB>C?CC#
@5XQ
CCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTN
+
@@@?DADACBACB;EHGHIIECB:CFEHI???DFGIEDCHEG<4?BGGGH;@HG?AC)55;@A@;@CDCAACCC@AC>>CBACCCCC?94(9@4@A382<#
@5XR
GATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
CCCFFFFFGHHHHIJJJJJHIHIJIIJGIJJJJJJJFGHIFGII?BFHDHIJGIJCHIJGHHHHHFFFFDCEEEDDD>BDDDDDDDDDCDCDDDDDDBD
@5XS
TCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAAT
+
CCCFFFFFHHHHHJJJJJJJEHGIJJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJFHIJJJJJJJJJIHIIIHHHHHHHFFFFECEE>ADCBDDD
@5XT
TGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATN
+
CCCFFFFFHHHHHDGIJGIIIIFHIIJIJIIIJIIJJBGHJHHIJ?FHIGHGGGIJCGGFHHHEHFFFFFDDEEEDDD@BDDDDDDDDDCCDDDDDDD?>#
@5XU
CGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTT
+
@@;BDD<DHAACCEAEGGGA?F9A??EGHGGGII)9DGHGII;FF(BFH@@F@ED@CEHAE>BDEEA9>;@CACBCC?:5::@>B?B<<?:A@CCCCAD
@5XV
GGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGACTGCCCATAGGTTGCAGTGGACTGAGCCTGGGGATAGCTG
+
??1D1=@22C?2<EE+,2AAE@<F?+2CF3:?DD?D9*0:BEII>?DE48?<?D8B0''-5(?;;6(>;A(;?;(5((5(,(,,>33+288&25<3+4+
@5XW
CCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGN
+
CCCFFAFFHHFHAGIIH@CDEHIGHADHHIIIHGIGIIIFHIHGIIIEIHCGBF>FEA>FEHIIIGHHIIIIEEHEC?EHCEFDBFEDEEC@ACCECDCC#
@5XX
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@=?D?BDA>FBCFEHIIG@FFH?DHGIGH?DDHIEAGDFAGEGIHIHIIEHDAEHHAHHBDEECC@CACD>CCCCC@>@CCCDCCCCCC>C<@?<9@CC
@5XY
TGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATN
+
=@;DBDDBFA?ACDBGAC:3<AFHHIFF<C?GGFAGF9?B@BBAGIFBA5A9@BD;?>AC@BC>@B=B?AB:=:=9<?>:?BB?9:BB@BA(:>4@>B@>#
@5XZ
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCC
+
CCCFFFFFHHHHHJJJJJJGJJJJIJJJJJJJJJJJJJJJJIJJJJIHIJIJJJJHHHFFDFEEEDCEEBDDB?CDDDDDCDCDDDBDDDDDDDDDD
@5Y0
CTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJHIIFIIJJJJJJIJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJIIJJHCHHGHFFFFFEEEEDEDDDDEEE#
@5Y1
CATAAACATCTCGGGACAAGCCGAAATCCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCTGCCAAGTCCCGATGAACGAGCTTCATN
+
C@@AFDFBHFHDHGIEGAEFCB<<DA?GDHBBGH@BDDDFFGICGGGCHECHE>@CCECCECBCC;@ACCCC>????CCA:ACDB@B@CCDB<BDDDDCD#
@5Y2
CATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCATTTTCTAAATCTTCCTTCAGTTTGGAAAGCTCN
+
?<?DBDDDDEDDDBED@<,,<<E>FE<EE99<<9F<BEFDEACFFCCBD<BDDDDE*?D9?9BDDD40*08B=B=8BAACCE7@C777AADAA3?)6);7#
@5Y3
GTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGN
+
CCCFFFFFHDHHHGIJJJJJJIGIGGIJEHIJJJIJJJJIIJJIEIIJJJJEHIGGHIIGHEEHCHFF?BECCDEDDDCDCCDB2;BCEEDDCBDCDDCC#
@5Y4
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@@7DDDDDHHFGHEGHHIJJIIJJJJIJBGIGGBFDHIIHHIIDBDFBAGEGHIJJJIJGIJIJIGHIJGIIH=AE?BEDCCCEDEDCCACC>C@CBBBD#
@5Y5
GTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGAGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCN
+
==?DDAD>3AAB>ECE@EEF@A3AACEFEDFAEDD9C88):0:B>B9?9DDDDBC?D<CA=BD==C<AACA3933>AAAA?A>5>AAA><<24:>&55;9#
@5Y6
GTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCN
+
C@@FFFFFHHHHHJJJJGHIJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJDFFFEEEEEDDDDDDDDEDDEEDDDEEDDCDDDDEEDDDDDDEEDDDDD#
@5Y7
CTCGGGACAAGCCGAAATCCGAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCTGCCAAGTCCCGATGAACGAGCTTCATCTCGGCC
+
?@@DBADDHFDFHGGGHHIJGCGIGHIHJJGEFIBBHIIJGIIJIJGECCHHFF>DFDDCEECCC@BBDCDDDDCD?@D>::<@DDDCD>>ACCDDDD
@5Y8
CTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTN
+
?<?D;::2)??+<<<<C<<CE9<9A229??<9*:CD>:?DCE9DEIDBCDD?=BDIIEDECD7@;@;AA?C6,99>68?8;8>AA>>AB:B:A::(4>::#
@5Y9
CTGGGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJHIJJJJJJJIJJHIJJHIJJJJJJJJJJJJJJJJIJHHHHHFFFFDDDDDDEDDDDDDDDDDDDDDDDDDDD#
@5YA
GCCGTTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTN
+
CCCFFFFFGHFHHIJJIIJJIJJJIJJJIGGIIJJJJJJJJGIIJJJJJJFHIIIGHIJJJIGJJIJ@GIHHGHHHFFFFDDDEDDDDDDDDDCDEFCCD#
@5YB
CTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTN
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJIGIJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJIIJJIJGIJJJJIEHHHFFFFFFFEEEEEED#
@5YC
GTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
??@DDDFFFHHHHGIIGIHDHHHEHHGIGHJGGFGIIGEHHGHIJGHJIFGHIIIJJJDGHHFEFFEDDDEECCBDBBDDDCDDDDDDDDCD??>@<BD
@5YD
CCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTA
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJIIJJJJGIHEIJJIJHJJJJJJJJJJJJJIJJJIJJJJJHHHHGFFFFFDDDDDDDDDDDCDDDD>A
@5YE
ATCAGCTCTCGTGAGTGGTACAGGACTCTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGN
+
CC@FFFFFHHHHHJJGGICHHJJJIJJJIJJJJJJJJJJIGHIIJJDFGIJJJJJJJJJJJJJ=AHHHHFFFFFFDEEEECEDDDDDD?BDDDBBD>BDD#
@5YF
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCN
+
CCCFFFFFHHHHHJJJJJJJJJHHJJJJJJJJJJJJIJJJJJJIIJJJJJFGHJJJJJJJJJJJJJHHHHHFFFFDDDEDDDDCDDDDDDDEDEDEDDDD#
@5YG
GTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGN
+
BBBFFFFFHHHHHJJJIJJJIJGIJGGGIJJJJJJIFIJJHIJIGIGIIHIJIJJJHJJJJHHGHHEF=AEEDEEDDDDDCDDD@DDDEEDDDDDDDDDD#
@5YH
CTTCAGCACCCCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATN
+
CCCFFFFFHGHHHIIIHIJIIIJJHHHJIJGGJEBFGHIIJJJIHGGHIIGIJJIEGHIGGHIJGGGGGIDHGIJJHHFHHGFFDFFECEDDDDDDEEDE#
@5YI
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
@B@DDFFFHHHHHJIIIIIGHIIJJIJJIJIHIIJJJJJJIJJJJIIJIJJJJJJIJJIJJJH:BDACCDCACDBDDDDDDDDDDCDC@CDDDDDBBDDD#
@5YJ
GGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATN
+
CCCFFFDFHHHGGJJJJJJJJJJJJIIJJJJIJJJHJJJIJIJIJJJJJJJJJJJIJIFIJJIEHJGHHHHFF?CFDCECDDEDDDDDDDDEDDDDDDDE#
@5YK
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJJIIIJJIJJJJJJJJJJJHHHHHFFFFEEEEEDDDDDDDDDDDDDDDDCCDDDD
@5YL
GGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTT
+
@@8BDDDDFFHDADH@FHD<F?<ACF?ABHIHIE<2?@ED?G???C?<?:B?D::?GEB@9D?BDHHIEFB<CB>G@=;7@C===7==AHE>A>CCD>B
@5YM
GAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTN
+
:8?4A?ADFBHHDGIIIEGEEHIEHIAF6GGGGFHEGE9DAGFFCGHEHEGGEAG=@CCCHGGEC@>CE@DBDB>DCACC@?B;@=/89<BBBACCCCAC#
@5YN
GTCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTA
+
@@@DDD>:CF?F<<8@1)8ECDGFFGFE>D@D?DA?DF6AAEE8A9B>DCC1;AB=1;8??5<5<?34:@@:<<<?AADBDEDDBBB>@AA@BB>:AAA
@5YO
CAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGG
+
CC@FFFFFHGHHHJJJJJJIJIHGHIJIIIIJJIIJ?FHEIIGJJJICGGJJJJJJIIBFHIHIFHH?EE@DF9A@ECECCDACDD:>@D,:?BCDDB
@5YP
GTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTN
+
C@@FFFFFHHGHHJIJIJGGIIIIJJIJJIIJJJJJIGGHIHIIJJGEIJFGIJIJJJIJJIJIIGHGGHIIIGGGHGIIEHIJJJIGGFDDDED@BB2=#
@5YQ
CACGAAATCCTTGGTCTCTAATCAAGTCCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTG
+
?@<DB8DBBHFFFBEGG@BEGCHCBHIIHBAFGIIHGGBCFHC1?BFGBF9?GECGHEGGHG>?DGHIIIIHGGHIGEHICDGHH7=E?B@CBDEEE6;
@5YR
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@?@DD1=A:+C<B?E??FGA@EAGFE;CB3??9?FFEGD>B?FGFBDFBBB?F9=F;3@AC=@@1CDAE3CFD:;;;@D??B'388?BBA>BA(48(88<#
@5YS
GGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGGGGAACN
+
BC@DFFFFFHFHHJJJJJJJJJIJJIJJJIIJJJEGHHIJJJJJIFCHIIJJJIIJBGGGIIJJJJJJJJJJJHHFFFFEDDDDDDDDCCCBDD5&&&08#
@5YT
CTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCN
+
CCCFFFFFHHHHHJJHIJJJJJIIJJJJJJIJJJIJIJIGGIHJJJJJGHIJJJIJJJJJGIIJIJJJJIHCHFFD>BDDDDEDDDDDDDDDEDDDDDDD#
@5YU
CATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCN
+
B@@DFFFFHHHHFJIJJJJJJJJJJJJJJJJJIHIJIJJJIIIJJJIIJIJHHFHHFFFFFFCCDDDCCDDDDDDCDDDDDDDDDDDDDDDCCDDDDDDD#
@5YV
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFFHFHFHHHIBHHIJIJJJJIIIJIIIIIEIGEHGJJIJJJGGIIIJJIJIEEHHHFFF9>B;ACCDCCDDDDDDCDDDDCDDDDDDBDBBDB#
@5YW
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTN
+
CCCFFFFFHHGHHIJJJJJIJJJJJJJJJEGIGHIJIHIGIJJJJIJJIIJJJJJJHHHFFFDDECCCDCDDDCDDDDDDDEEEEDDDDDDCDDDDDDDD#
@5YX
GACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAA
+
CCCFFFFFHHHHHHIJJJJIIIJJHHIJJJJGIJIIHIJJJJDGGGIJEFFFEEEEEDDDDDDDDDDDDDDDDEEDDDDDDDDCCDDEDDDDDCDDDDD
@5YY
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGACCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
?;?DDDA2C8ADDEIBBEIAAF33AE9CAB@AE<9C?9<??79?)?BEE@999?DCEC><)==CAACCACDC)77?77=@D?),',;;?(5:AA;>>;;A#
@5YZ
CTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCTTTATCTTTTTCATTTTCCATATATTCACGAACCTGATCCACATGAGTTGAATAAACC
+
BCCFFFFFHHGHHJJIJJJIJJJJJHIJIJIIJIJIGFHIFIJJJJJIJJJIJIJJJJJEHJJJJJIJGIJJJJHHHHHFFFFFEEEEEEDDDDDCDD
@5Z0
TCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJHIIIJJIGJIIJHIJJIIHIJJIIJJIJJJIJJIGHHHGHHHFFFFFFDEEDDCDDDDDDDDDCCDDEEDDDDDDDD#
@5Z1
CTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTN
+
CCCFFFFFHHHGHJIIIGJJJJJJJJJJHIJJJJJJJIIFHIJIJBGIJJJJJJJHDHIEGGIIIIJ5@BHIJHGHAHHFFFFFCDDDDDDDFDDDDDBD#
@5Z2
AAGGAGATTGCCTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCAC
+
@C@DDFFFHHGHHJJJIJJJJJJJGGIJIIJJGHIIIJJJIIJJJJJIJJJGIHIIJJIIIHHHHFFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDD
@5Z3
CTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCN
+
@B@FFEDFHHHFFIJJJJGHJJJJJJHHJJJJJIIJJI@FHIJJJJJGHEHHGFFFFDEEDDDDBDDDDDDDDCDDDDED@CCCDDDDEDDD@DBBDDBB#
@5Z4
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCN
+
@@@DDDDDFFFH8;EDFFGGE9H>AGD>FHGG0?FDEGECHIGIGB;B=@>A4=<3;=??B(;>CCCCC@@9<59>-9>:>:A<<<5<A93::7:4>3>3#
@5Z5
AGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
CCCFFFFFHHHHHJJJJHIJIJJJJJJJJJJJJJJJIJJJJJJJIJIJJJJJJJJJJJJHGFHHFFFFEEEEEEDDC>BDBDDDDD3<BDDDDDDDDDDD#
@5Z6
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFHHHHGJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFF9?B@CDDDDDDDBDDDDDDDDDDDDDDDDDDDDD#
@5Z7
GGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTN
+
CCCFFFFFGHHG@FHIJJJJJJIHHJJIJJJJJJIIIJJGHJHIGGGGIIHIJIJEIIJIJIJFJJJJHHHFFFFDEEDEDDDDDCDCCCDCDEDCDDDD#
@5Z8
CAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAA
+
@@@FFFFFHHHHHJJIIJJJJJJEHIJJIJJJJIHJIEHJIJIJJHIJJJIIJIJJJIGJJIGIJJJJJJGIGJJFFFHHFFFFFF@DEEEEDDDDDDD
@5Z9
TAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCN
+
CCCFFFFFHGHHHIJJJIJJGHIJJJJJJIHIJJJJJIJJJIJJJJJJJJJJJJJIJJHIGIJJIJJJHHFFDDBECDCFCDDDDDDDDDDDDDDDEEDE#
@5ZA
GGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGN
+
@@?DDDDBFBBDFFHG<FHHHEHEEEEHIGGEDDDFFDFGIJGHGA@CECD>EH>B>?B@@CECEDBDDCCDACCDDBDD9>BBBDCAD>:A<ADABCCD#
@5ZB
CCCCCTTCCGGCATGTAGGCCATCCTCTCATCAAAGTGAGAAAGAGGCACTGTATCCTCCTCGTTGATGTGACGTTCCATGACTGTCTTCAGCAGTGGACN
+
@@@DD<DDDC1::?BCE<F9FFF98C@?;9C99D4D?B<*?DB?F3B1;BF>8)))8)@@CC5=1?E@3A)7?=B=;?A>;(;A5>@35,3,(,(53>3>#
@5ZC
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATN
+
CCCFFFFFHHHFFHIIGIJJJJJJJJJJIIJJJJJJJIJIJIJJJIJJ@FHAHIIGHHHFFFDEEEEEDDDDDDDDDDDDDDDDCDDDDDDDCDDDDDDD#
@5ZD
CAAAGCATCCAGTAAGTGTGAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTT
+
@CCFDFFFHGFHHJJIGHJIIIEIHIIJIGIIGJJIIIGIJJIJJIJIIIJIIJIIIIIJIIJJFHIHHHIJJJIJHEE?EEEFFFFCEEDBBDB2;BD
@5ZE
CTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCN
+
@@@DA;D>?DFDFDGHG>IHGFCAGI3FHC?9<F@EGGHIIIGC>D9C<GD>DBD@BGHIICHIFGF<FGGEA=E7.77?>EEE9@D>;@C@AA@C;@CC#
@5ZF
GGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCN
+
@7@DDADBD?BFDB:<AFBHC@GHIGEA?EHIGIGEACGDBGGI):?8B??FHG4F8==F>FG)=)8;DAAAAB2?=B=;,>C@>9AC:>4>>C988::A#
@5ZG
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
CCCFFFFFHHHHGJJJHIIIHIIJJGIJIIJJJJJJJJJJJJJJJJJJJJJIJJJJJJIGHHFHFFECCCEEEEEEDDDDDDDDDDDDCDDDDDACBDDD#
@5ZH
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATN
+
@@@FDDDFGHGFGIJIAFHEHIIECFHG@AFGIEC:BFHIDHIJJIJJJDHIJJIJJABEHHGHFFED@CEDCCEDBBBDDDDDADCDCDDDDDDDDDDE#
@5ZI
GTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTN
+
@@@FFFDDHHHHAFEHIGGGFFHEHGJJJJIJJJJJJJGHGEHHAHGFF@@DEEA>CCCCDDA@DCDBD;@C@BD<BDDCD@CCDDCCDD>C?9A>A?B<#
@5ZJ
CTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCN
+
@B?DFFFFGHGHDIGGIJIJGJJJHCHJJIIGIJJJJJIIJJJJIBFEIIIJH;A?CEEFFEDEECDDDDBDDCDDDCCDCDDDCCDDDDDDDDD?BD?C#
@5ZK
CAGGTTCTGGGAGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCACCAGGN
+
CCCFFFFFHHHGHJFHIJJJJJJJIJJJIJJJJIJHIJJJJJJJJJJJJHJJIJJJJJHHHHHFD@BDBBBDDDBBBDDD@BBBD@DDDDDDCDDDDDDD#
@5ZL
AGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTN
+
CCCFFFFFHHHHHJJIJJIJJJJHIJJIJJJIJIJJGHIIIGIIIJIJJJJEEHHHHFFEFFEDDDBBDDDDDDDDCDCCDDDDDDDB9>BDDDDDDEDD#
@5ZM
GCCAGCAGCCACTGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCT
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFEEEEEEEDDDDDDDD5>BDDDDDDDDDDDDDDD
@5ZN
CCCGCTCATCCGGGTGGTCCAGGGAGCTGGAGTTGCGGCTGCCTCCACTGCCCAGGTAGCCAGGCCCCACTTTGCGGCTCTCGCGGAGGAAGCCCCGC
+
CCCFFFFFHHHHHJFHJHIJJJJIIIIJJJIJIIJJJJJJJHHHHFFFFECEDEDDDDDDDDDDDDDDBDDDDDDDDDB@?C>BDDBBDDDBBDDDBD
@5ZO
GTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCGAGGGCGGN
+
B@CFFFFFHHHFHJJJJIJJIJJJIIJJJJJJJJJJJJIJJJJJJJJJJIIJIJJJJJHGHHHHHFFFFFEDDDDDDDDDDDDDDDDDDDDBDBDDDDDD#
@5ZP
CTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCN
+
@C@DFFFFHGHHHIJJFIIJJJJIJIIJIJGHIJJHFGHIIIJJIIIJGIJIJJJJJIJIJJIIIJJHHHHF;BC3?B9?CCCDCEDDDDACC@@D9@CD#
@5ZQ
CGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCN
+
@@@FFFFFHGHFHIJFJIJIJJIJGJIJJIJJEFFCEEEEDDDDEDFDDDDDDDDDCDDDDDDDBCDDDDDDCDDDDDDCCCCDDDDDDDDCDCCCCDDD#
@5ZR
CTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTN
+
@<;BBDB>FFFHH?GHGGGG>CE<ACEFFBH@FDHEEGHHI>DDHIGDB@DFHIGIIIIHIIIICFGGAGHIGAHDHGIDEHHACHECDBBBDCCCCCCB#
@5ZS
CTGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
CCCFFFFFHHHHHJIJJJIJJJJJJIJIJJJJJJJJJJIJJJJIJJJIJJJIJIHIJJJJJIHADDACCDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@5ZT
CGCATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGN
+
CCCFFFFDHHHHHJIJJJJJJIJJJJJJJJJJJJJJJIIJJJJIJJJJJIIIJHEHHFFFFFFFEEEEEEEDDDDEEDDDDDDDDDDEDDDBDDDDEDDD#
@5ZU
CTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGGAATGAGGCAGGGGGGGTN
+
???:B4AD??:C:AEAEE:?E<ABCEEEECF;;EE8DD@?:DABDC;DDD@?/??8.8B=88=CDI;7;.@7?=CCA<A@;;',;>>AA>;5<=;;>??)#
@5ZV
GCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTAACCTGCCGCCTTAAATCACCAAGGTCTTN
+
@8=ADDBDFFBDFD?FE@IBEHHFEEF><FHABCHGAHHICHGBDHCFH?BFDDDBFCFDHDFDBFDH=BGGACFHIEEHBBBBCBEEECCC@?A?C:@C#
@5ZW
ATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCN
+
CCCFFFFFHGGHHIIJIJJJJFHIIJJJJIIIIGHIJJJIGIJIGIJJJIHIIJJJJGFFED@CECEEBC;?AABDCADCDEDDDDDDDDDDDDDDDD@D#
@5ZX
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@@DABDD??FB;;:CEHIIBHBEFGEBFBB<8:??9FGBH9?D<F8?FH;FH@=35=;@=@>EAHEC>:>;63@A>A35;5(,5,55,:>@>C:4(4
@5ZY
GTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCN
+
@@@DFFFDHFAHDGHGGHG@=HHG?GE<FHGHIGAHGBFFHHHC@BHEHDFFHHAHII=FBFGGGIGGGIEGGHGIHEHEEEEFCBB@DCCACCE;AC@>#
@5ZZ
TTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTTCAGCAAATGAAAAAGTGTTCCTN
+
?@<DFFEDHFHHHIIGHEAHECCH9FFHG;?FBBEHGIIEGGGDIBEGEGHIH@GD@GDFEG@@GGEHGIGHEHIHFCE>ACC?CC>CCCCBBC@@>CCC#
@600
CTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGN
+
CCCFFFFFHHHHHHJFHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJHFDDDDDDDDDDCDDEDDEEDDDD>CDDABDDDD#
@601
GTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTN
+
CCCFFFFFHHFHFGIHHIIIJIIGHJIJJIJIJGIGIGGBGGHIJJIIGGHIJIDHHHFHHHHHFFFFFFEEEDE@C@CDDFDDDDDDDDDDACACCDCC#
@602
CTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGA
+
CCCFFFFFHHHHHHHIJJJJJJJJJIJIIJFHIJGJJJJJJJJJJJIJIJIJIJJJIHIJJJJJIJIIGIHHFGHDDEFFFEDEEDDDDDDBCCDDD
@603
GTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCN
+
@@@DDDDDHHFHBEGEDBGDGIIGIIJJGFGHGGHJICGIEHJEG=FGGGGIIJEAHHECCBEECDEECC@@CCACDDDECCCCA:CCD?BCDCCDABDD#
@604
GGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTN
+
CCCFFFFFHHHHHJJJJJHIHIJJJJJHIJJJJIJIJJJHIIIJJJJJJJJJJIJHHFFDCDDDDBDDDDDDCDDDFDDDDEDDDDBDDDDDDDBDDDDD#
@605
CCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCT
+
@CCFDEEDHHDHHJJIJJGIIIIJHGHIIJFGIGIIGIIJEGIJIJGHFFFDEDEDEDDDCCDDDDDDDDDBDDCDDC>CCDDD
@606
ATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATA
+
CCCFFFFFHHHHHJJJJJHIHHIIJIJJJJJJJJJCHIJGIJJ?FHIJJJJJJJDHIIIHHHHHHFFFFDEEEEDD@BDDDDDDDDDCCDDCDDDDDDD
@607
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
CCCFFFFFHHGHHJJJHHJJJJJJJJJJJJJJIJJJJJJJJJJJJIJIJIIJJJJJJIJJHHHHFBCD@DDDDDDDDDDDDDDDDDDDDDDDDDBDDDDC#
@608
AGATATTTATCCTTGATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGC
+
CCCFFFFFHHHHHJJJJJJJJJIIJJJJJJJJJJJJJJJJJJIHIIIJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJIHHHHHFFFFFFFFEEEDEED
@609
CCTGTTTGCACATAGTTTAACACATCAAGGTTGGAATGAGCTGGATAAGGCTGATGACCAAGAGTTAAAATCTCCCAAATCAGAATTCCAAAAGACCAT
+
@@@DDFFFGHFHHIJGHIJIHIIJIEIGIEIEGJEHIIIJIJIEHJJGIIEGE@FBBDDHCE;CHIIJJJIAHHGDHHGFBC@DDCEEEEEED;??CDC
@60A
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJGHIHHJJJIIJIJJJJJJJIJJJIJIIHHHFFFDEDEDDDDDDDDDDDDDDDEEEEDDDDDCCDDDDDDDD#
@60B
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGGTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGGTTGGGGTGGGTAACTAGTGGGAGGN
+
?@@=DD?1CAAFDG:AB,<A3<F8CFC4?E<C*1:*0*??GF<<BDB89D<B8.=8)=C:8;=CE(=CACEED3;)7;698;3''-)43+:>@(((((+5#
@60C
TAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCN
+
@C@FDFFFGGHHFFHIIHIIIIIJJIGIJGIIJJJJJIEIDGGIGIJJJIGHIIDHEHIJGGIJJJGJGHHGIJFGEHHHFFFFDCCDDCCCDDDEEDDD#
@60D
TTCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTN
+
@@?DBDDDDHFHFEEFHII<@GGIIDDC3DF@HIGGEDG@DFEDHFBCFGAGEIIICGCEDHHHDEABBEECCA=>BBB>ACC><?B><?ACCC@CCCCC#
@60E
AGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGN
+
@BCFFFFFHHHHHJJJJJJIJJIJJJJJJJJJJJIIJJJJJIJJJJDDDDCCDDDD>CDBCDEEDDDDCDDDBDDDDDDDDDEDDDDDDCDDCDEDDDCD#
@60F
GGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTAGTCGGGGTTGGAATTCTTCAGGGATGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCN
+
@@@A7@)0<CD?FEF:A4<A3A1?))??CCD@D*?000*08?0<;F<DE@CE))7?3)6?)5((6(,(3,'5(:((,((+:(+44>(98?2&09@@.??8#
@60G
CGGGCAGCCAGGGTGGGATCCTTCAGGGCCTTCACAGCCACAAGCATCTTGTCCTTGGTCGGGCTGAGGTTGTAGCACTCGGCCAGGAAGACCTTTCCA
+
CCCFFFFFHHHHGIJIIIJJIJJIJIJJJJJJIFJJJJJIJJJJJJJIJJIHJJJJIHHHHFDDDDBBDABDDDDDDDDDDDDDDDDDDDDDDDDDDDE
@60H
CCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTN
+
CCCFFFFFHHHHGJJIJJJIIIJJJJJIIJJIIJJJJJJJJIJJIJJJIJJJJJIJEHIIJJJIJJJJIHHHHHHFFFFFFFEDEDEEDDDDACDDDDDA#
@60I
AGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTN
+
@C@FDFFFFFHDFGGGGGGGGHIGIJJJJJIGGIGHCGHHGIHJJIJIHIHGJJIIJIIIJHEHIJJGCFGGCHGIHGFEFEFFDDFBCECECCBDDECA#
@60J
CAGCTGCAGGTTCTGGGAGGTGACTGTCAGTTTGTCCAGCCGGCCCTGCTGCTGGTACAGGAAGTAGGCGGTGGTGGCCTGGCCAGCGAGGAGCAGAGTCN
+
CC@FFFFFHHFFHIIIJIJI<FHHGIJJIJJJGHIJJIJJJGGIIJJJJIGIGIJ@EHHGHHFFEBDDCDDBBD@@?BBCBDDBCDD<BDDBDBBCCAAC#
@60K
CTAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCN
+
@@@DB:BDFDBHFIIJJEGIIIIJEBHIEHGIIGGIIHIIIJEHIGIGHIFDCGDDGGF@GIGHI=DHIAHFD?@BACD@?CDB5<>CCCDDDDDDB?BD#
@60L
TGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACAT
+
??;DBDBBD?CFHGAHDGE:A<CHB@C+<<<<F?FEGBEDGHBH?GFH<FG?8C=;2=CH76=CD)7;AADBD@D>C@@C>(;5;?B?9@>5,,(,:AA
@60M
CGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJIJJJIJJJJHHHHHHFFFFFEEDDDDBDDDACACDECDCDDDDDDCDD#
@60N
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGN
+
CCCFFFFFHHHHHJJJJJIJJIJJIJJJIJJJJIJJHHIJJJIJJGIIJIJJJJJJJEHHHGHHHFFFFFFEEEEDDDDBDDCDDDDCDDDEEDDDDDDD#
@60O
GCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCAGAGCAGGACACCAAAAGACCATN
+
???7DDADDD<DD+AE2<C9D:?;;>:):D6;B*6?1(B98?)81B<A;A@A->C).)7=@@AA9(-,(9((,(:>A?((2((+8(<98(+8<?A8<??A#
@60P
CGTAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCAT
+
=;?1=DBDFDFFAEGFEFF<<E;?<AFF4?CEE@FCFCEB?DFGICE;@DFFI@FFF.=BBFCGF=FGBE;@@CCE:C?:;;?>?=@;;@,359(5>>A
@60Q
GGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTN
+
??;ADD?DDDDFDGHGCHGGEGIEDEGAGGGHIICGGIIIIIIIIGIGGGC@DDAG<FHGBC4@FGAHGIAEEAEHEHHEED?BCCCCCC;>>CCC@C5>#
@60R
GTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGN
+
CCCFFFFFGHHHHJJIJJJJJJIJJJJJJJJJJJJJJJJJJJJJHIIJJJIJIJJJJJJJJFHIJHIJH?EDFDFFDCED?BDDDCDDDDDDDDDDDDDD#
@60S
GCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGN
+
@@@D?@ADB?FDFHGGG=HAGHIFIGB:D>??BG>98D?DG>F?F>===CF@=FGC>)@4=?CC3=;;;BA;=B@8=855;>C(58<+++4:A::A3@@C#
@60T
CGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCN
+
@@@BDDFFFFHHGIJIIGIGCGGIIJIEGHIJHIJIBHIJJJJIJIIJJIIJGFGGHGIIJIJHHHHECDFFFFDC@EEEDD@BBCCDDBDDDBCECDCD#
@60U
CTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAA
+
CCCFFFFFHHHHHJIJJJJIIIJJIIJJJFGEHGIIJJJJJJJJHGHIHHIJIJJIIIJIJJIEHGIJJIJJJIJGIIHHHHHHGFFFFFFEEDEDDED
@60V
AATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTN
+
CCCFFFFFHHHHHJJIHIJJIJJJJJJJJIJJIJJIJIJJJJIJJFIHGHIIIJJEGHGIGIGIIIIJJJJJJEFFFHHHFFFF@DCEEEEEDDDCDDBD#
@60W
CCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHFFCEFFDDDEDEEDDDEDCDDDDEDDDDACDDD#
@60X
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGN
+
CCCFFFFFHHHHFEHIIIJIJGHIJJJIIIJJJJJGCHGGHIDGHGCAHGG>FHIIIHI8@FD@FGH-=ED>BEFCEDAADDDCACDDDBBC@BDCCDDD#
@60Y
CCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGC
+
@@@;BDDD=ABDHGEFEAEFEGEGIGGIF)?F?FHECAFHGDGEFBBFEFG9DBFCHB=8BA8CF=@FCE=DGGCEHEHD@C?CCCCBC6;B8@><CCC
@60Z
GTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTN
+
@@@DDDDDHHFHHIAHGGGBHIIIIIHAGHHEB=BB@BEDCD?@@B?BBDDDDDDCBCCDECDCDDEDDDDDDD98>?AACDACCAACDD?C@BDDDC@C#
@610
GGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGT
+
@@@DFDEFBH?H?AGHI;GBHIAFDCF3:3?DCBF@G?BBDDBBB??D*BB@3CGG:FH@@F@D7C7@@;CEE,,,6>>>;;53;;;8>@::C:@955+
@611
CCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGN
+
CCCFFFFFFHHHHJJJIJJJJJHIJJJJJJJJJJJJJIIJJJJJCHIIJJJJJJJHHHHFDDDDDDDCCDDDD?BBDEEDDDDDDDDDDDDDDDDDDDED#
@612
CTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGC
+
@CCFDDFFHHHAFDGGHGDGHGGHGHIGIEG<@F9?DFHI@FAGBGHFCGEDGGHIAECEFFFCBDECD9>@DCACCDC?AC
@613
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
@@<DDDFFHFFHGEEGGIGII?:CFHIIIEEGFF?DF@GGIICE4?9BFHEBBGHIIFHA7@CGGHGH7=AEEFD;A@C@;AAABCCCCCCB5>CB:AB@#
@614
CAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCCN
+
?@@FAEDDHHCFFHIICHHIIGGGIFHAHHFHGICCGIGIBFHFGIGIIBHFHIIHGBHCCHGHIIIEHHHFFFFC;>CE>88;?C?@9ABA@C?CB?CC#
@615
CTGTGGCATCGCCTTTGGGCTTTCCTGTTTCCTTGTCCAGGTAGATGTGGATCATGGGTTGCCCAGTTCTCTTGTTCATCTTAACAACCCCACACTGCTTN
+
BCCFFFFFHHHHHIJJGHIJJJJHIJJJJIIJJJIHIIJJJJJJIJJHIJJJJJIIIJJIIJJJIJHHFHHHHFFFEFFEEEEDEEDDDDDDDDDDCDDD#
@616
ATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGCTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCG
+
CCCFFFFFGHHHGJJIJJJJJJJIHHIIIJJJJJJIIJJJIJJJJJJJJJJJJIHIJJJIIJJJJJJJHFFEEEEEEEDDDDDDDDDDDDCDDDBDDDD
@617
GTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTGCTCTN
+
CCCFFDFFHHHGHJIIIIJIJJIJIIIFHIJJJJJJIGGIJGJJJJJJJJJJJIIIJIIDGIGIGIGJJJHGHHHHFFFFFFEEEEEDDDDDDD?BDEDD#
@618
TATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTT
+
@@@FFFFFCFFHHIGJJJJJJJJJJHJJGHIHIIJIJJGGGIFGHIIIJIHIIJIIIJJFGHIIIIJJJIJIJJIGIIFEHHHHFCDFF@DFDDEEEDE
@619
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@@@DDDD?C?BFD:AA:AHIIEFAHIIFB998;CFFF9?<FFA:D>DGF<?*9?F>FFFCFBF>FFDFFEIE?.5==;B@;>;@>3>A>>;3;(::5<@@#
@61A
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCAT
+
??;DDEDEHDFHHGIGGGBBBFEFG>HIFEDDCFEHC>HHGEGIIIGEBGH8?FEFEFGIIGIIIIIGCGEEEECF@BD;?AA=>CC?C?@C@CB@::
@61B
CCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATAC
+
@;@?DADDFF<FD:+:2C?CFADEFDFH?CEBD@BCGDAB?BBBD<FFE;?FFEII=CC=FC@ECEEEFFEFF3=>BDDDCC?B?@?BAABB@ABBB@
@61C
CCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGN
+
=<@DAD@DHHHHDDGIJGGHIGDCGIG1CFIJIJGIJJEGHGGHBHGIIJDHDEGIJGH@EEEEFFCEEECACBDDDDDCCCC@CDBB09<9:@AC:A@B#
@61D
CTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGN
+
CCCFFFFFHHHHHIIHHIGJJJJIJJJJJIHHIJIIIJJJJJJJIJIJIJJJJJJIHIIJJJIIIJHFDDDDCCDDDD>CCDDCDEDDDDDDDDBDDDDD#
@61E
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFDFGHGHHJJJIIJJJJJJIIJIJJJJJJJJIIIJJJIJIJJJIGHIJJIJIJFEHHHFDD>BB@DDDDCDDDBBDDDDDCDDCDDDDDDBDDDD#
@61F
CGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTN
+
CCCFFFFFHHHHHHIJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJIJGHIJJJJJJJIJJIGJJIJJIJJJIJJJJJJJIHHFFHGDFFFFFCEEEDDD#
@61G
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGA
+
@BCFDEFFHHGHHJJJIJJIIJJJJJJJJJJJJIJJIJJJJJIJIIJJJJJJJIIJJDDDDDDDDCDCDDEDCDECCDDCDDDABDBBDDDDDDDDDD
@61H
GGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGN
+
CCCFFFFFHHGHHJJJJGHHIIJJJJIIIJJJJIJIJJ?DGHHJIIIJJIJJJJJIIHIIIGIGIJIIIJEHIGEHHGGGFFFFFFEECCBBDDDDDCCD#
@61I
AATGTCTCTAGGTACAGAAGGCATAACACTATGCCACTCACCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATN
+
@@@DFFFDHFHHCFFHGIJGEGGIIIIJJJJJGIJIJIJGIJIGJIIGGIJJGEHIIHIJIGHGFIJGGHIEFHHCHFEDDFFE@CEEEDDDCACCCDAC#
@61J
CACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATC
+
CCCFFFFFHHHHHJJJJJJJJJJJJIIJJJJJHHIJJJIJIJJIIJJJJJJJJJJJJJIIJJJJGIJJJJJJJJIJJIGGGHHHGFFFDFFEEEEEDDD
@61K
TCACCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGN
+
@C@FFFFFFDHGGHHHIJJJJJJJJJJJJJJJGIJJJJJIGGIIIJJHIIJHGJIGIJJJJJGIIJJJJIJIIGHIJJFHGHHDDEFFFEEEECEEDDEC#
@61L
CAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIIIIJJHGHHHFDFCFEEEEEEDDDDDEEFDEDCDDDDDDCA#
@61M
GCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTN
+
C@CFFFFDDB?FHHABHIIEEGGHCBGGGIGDGGGIEGGGGCHGHGIEDFFHGGIGGGGHHBFFCCECBBBBCBCCCCCCCCCCCCB9@B2<AAB<BBB9#
@61N
GTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATAC
+
CB@FFFFFHHHHHJJGJIHJJIJJJIIJJJJJJJJIIJJJJJJJIJJHFHFHHJJJJIIGHHEHGIGIGIIIIJJIAHHHHHHFEFFFFEEEEEEEEEE
@61O
CCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTN
+
C@@FFFFDHDFHHHGGIIIGHFGGIGFGFIJJHHIJJFGIIJIJJJIIJJJJJJEGIHHHHHEFDACD?ABD@BBDCDCBCDCDDDDDDDDDDDEEDDDA#
@61P
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@@@DDDDDBBDFD<ABEFHIEHHDHDHICDD;??FFFBHIBDHGE@BFHHCFF>GBBHDFA>=FG@@=7C@@@7:?=BDAEACEEECA>@CACCCCCB@?#
@61Q
GGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGGGCCATN
+
?;::DDADFBCFHIGGAGDHIGEHGHHICDGGHIHIII@A@FBGGIG?BDGIFHECEECEC@DCEC>=@DEECCACACBB?@>ACACC?@?<@B(85@B?#
@61R
GTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGGGTTCTGCTGAGAGTA
+
?@@=;B?B,A:+22@<EB=BFHECAEEF9@E>CDDCBBFECFCF@B@B@<DCCBACECC>F7@DDA:@7@EE=>B>BCCC>>>(98;9:@ABB,2+4+4
@61S
CACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACAAATCACATCN
+
@@@DDBDDDACADF<?FA@HHE>CH@FHBA:?F9CEGCBGGC?BBF?B9083?FGD@BBHHG@=FEGCC;;C==7@=A??=?AC?D;@?AAC6A;AC>>;#
@61T
ATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATN
+
@@@FFBFFHGBHHGGDGHEGIIJGJIJJFGIEHJJIIHIJGIIJJIIGIJIJJIIIHHHHHDFDFEEEEECDDEEDCDCDDDCDDDCCBBDDDDDDCBDD#
@61U
CGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTN
+
??;ADDBDDDDDD@AEEEE3ABC2A+:?B?EEDEFEDEIADCEDDD>DDD;CDCECAEEIIIIICDDACDDDDC@ADD@AAA@AAA>>AA?5=??AAAAA#
@61V
CCGCCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGT
+
CCCFFFFFHHHBHHIJJJJJIIGHJJIIIJJJIJJIIIJ?FGHIIIGGIIIJJDDDBDD@BDDDD@@BDDD-9?CDEDEDDDDB>BDDDD3<B@CDCCA
@61W
CATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGA
+
@<?DDDDDBFHFHIEIIIIICGIEGICFGGBFCCFHAG?F?BFHGIIIEGHGBGHIIIICGGIGGGE?CECEEEDE>>7;;@CBDCCC@CAD>AAA5>
@61X
CTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGGGGTN
+
@@@FDDFDHGHFHIGIGGGGIJHIIHEGGGIIJIJIJIJHHHHHGIIJJIIIIGGGIGIIFAGGIIEIFEHFFFF6=B3=?;@DCDDCDCDDD@CD(5<5#
@61Y
CCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACN
+
?@@D1@DDFDFF?4??<A++<+=:BC3A?A9?FGCB<?<*?BB?:?*909(??C9.=83().>).==)=C).??C)7?;?@@?76;6>?.;ABA(5(,(,#
@61Z
CTGGATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGTGGCTCCAGTN
+
@@<DDFFFHHHGHIJIBCEECEGHGGHGGHEAGIJJIJGGHCFDHDGGHJGIJGDEGHIJGIEHIGGGAEFCEFFFFECCEDEDDDEDC>@<BBBCDD:A#
@620
TCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCATTGCAGCATCAGGCGGTACATCTCCTCGCTGCAGTTGTCTGN
+
@@<D=3=BAFDFHGIEH<<CEEGIIGGIIIE>FHGIIHIHIIGIIGGIGGFHEHHHDEDCEEAC@>ACCCCCCBB><BCECCCCCC3>B5<CACCC>4>>#
@621
CTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATN
+
BCCFFFFFHHHHHJJJJIIJJHHHIIIIIJJIJJJIJJIJGIIIIHIIIHJJJIIIIJJIJJJIJJIIIJJJIHHHHGGFFFFFFFEEDEEEEDDDDDDE#
@622
CGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTT
+
@@@D?@BD?<BB>F<FHD<A;F><?8AF4?:GEG:?9DF@GID@D??8??DBGA@EH;CC;C;AH;7?@??>@@C@;@@A>CCB55>>:>35::>:9
@623
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
@CCFFFDDFHHGHIJJJJGHIIJJGHIEFHCFHIJJJJJJJJJJIFFGIJJJJJIIHIJIJJJGHHFFFFDEDEEEDDDDDDDDBDDDDDDCDCCCCDD
@624
CTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGN
+
CCCFFFFFHHHFHIJIJJIIFGIJJIJJIJIIGHIIIEGHHIII?GIGHJIJGHEH@GIIIIJIJIHHHHHEFD;@CFECCCEEDDDDDEDDCDDDEDDD#
@625
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHGJJJJJHHHIIJJIJGHIIJHHJJJIIIIGIJJIIIJJJJJJIJJIJJJHEHGHHFFFEEEDACCDCCDDDDECCDDDDCDDDCDD
@626
GGGCTGTCCATAGGTTCCATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGN
+
;?@DDDDDHD?FHIACGHGHIBGGEIGHGAHEGGG8EGHIII<?DHH9DCGG@C<G<DGHGIIIIFEEG>CE@EDHCAEDDCC>6@CDC>ACCCACCC@C#
@627
CGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
CCCFFFFFHHHHDIJIJJIJJIJIJIIJJJIJJJJIJJJJHHIJJJJIHDHIGIGIEFGGIFGEGCG@EHHHHCAEEEFFF;A@CECCDCCCCCCCD
@628
GGCCCTGTCTGCTGACCTGTGTATTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGN
+
CCCFFFFDFFHHHJIIIIJJIHIJJIIJJJJJJJJJJIEGHJGJIIIIIIJJIJJIJJIJJJJJGIGGIJIIJHGHFHFFFFFACEEEEEDDDDDDDDDD#
@629
GCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGA
+
@@@DDDDBAAF+2CFCEFEGFCHIEGGGAHHIBBFGHHDGBC>@FIGHBD9DACDHHBDH?@CBDHCF>GHGGGIIFDHGGGEEEHEEEEEDDCAC3
@62A
CTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTN
+
@@<DDDA?<?FF<DG=GB:@G@FF::??GE<:DB?BDBF?DF0?BBFFFFF>FFAAC@DE>E>??EFBDBDA@ACCBB=><<@9:;@AABBBBBB@<>BB#
@62B
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGGGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
@@@DDD1D<FDCDEEIEHIH<CFGGHHGFBGGCC*?<GH@A;?388B@CEH>DCGF@ECGAE(?BDB6@;@C>>>?CCCCCC?>C>ACA(59@?A018+)#
@62C
CCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATN
+
CCCFFFFEHGHHHJJIIGJIJJJJJJJJFGIIHIIJJJJJJJIIJJIJJJJIJJJJJJJJIJJJIJJJJIJJJIEHHHEFFFFFFDDD@?B@CDCCDDED#
@62D
GTAGGATCCAGTTTGGGGGGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
?==DDDDFFDFFFHGIII)0:B7BCCDCC@@???BB?B@?CCCBBCCCCCCCACCCCCCBCCCCCCCCCAC@C:A:@CCCCCCC>@@>CCCBBBBCBCC
@62E
CGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATN
+
@CCFFFDFHGFHHJJJCGEFHHIJJIJJIJJJJJJAHFHIIIJJIJIIGEEDEFFFCEEECDEDCCDBD@CDDDDB>CCDDDDDCDDDDEDACCCDCDDD#
@62F
CTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCN
+
BCCFDFF?FFFHHGHDHIIIJIIJJHIGGIGGFFFHJGGHDIIJJGEIJJIGGDCHIIIGHHIGHDHAGHEHFEHHFFDEFFFFFECEEECCCDDDDD?C#
@62G
TTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCT
+
CCCFFFFDHHHGHIJJIJJJJJIJIJJJJGIIIHJJJIIIJJJJBGIIJJIIIJDGHGIHIIJIJJHHIIIJJHH7?EHFFDFDDCBDDDDFDFDDDB?
@62H
GCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACCTCTGAGTCATATN
+
@@@DBDDDBFHF<FF>>3A:CCEAD4CF>HIIIEEC3??C?BBB:;?BDH@<<FDHFH=F@@>FCHCGG;CC>.6??DDEBC>A>;((-5;(((5>:>@5#
@62I
CGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGN
+
@;@;;0@DF>CFB@AFEBHF>;78<CFFCGFFFCFCD?GEGF@>BBB?CFACFIIF6E>>6=??EF:??B;@@@@>ACAABBBBA@>AA::??BBBB955#
@62J
TAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCCCCATGTTTN
+
@@@BDDDD?B<AA<EGG<<AF:A:ADEHBBF+CAE@?9???F@?F<9::B99??FCBBGB9B@?BFDGC@BC@BB@AD7C=@7C@@EF;=>)=9@;@.6>#
@62K
TTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJIJJJJJJJJJJIIJJJJJJJIJJJJJJJIJJJJIIIIJIGGIIIJJHHHHHGFFFFFFECECCCCDDDDD
@62L
GCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJIJJJJJJJJIJJDDDDDDDDDDCDDDDEEEDDDDCDDDBDDDDDDDDDEDDDDDDDDDDDEDDDDDD#
@62M
GGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTN
+
@@;DDDAA<D<AD@EGI+AABBCE@@???;DBGIEHGH?G:FHIICCCC;.==C=@=DE;=?;@;C?>CDDDCCCCA>@AC>;>CD@CCCCC?@BBC>B<#
@62N
CCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCAAGCGGCGCCCCCAGCCCCCTGAAGCCCAGGTGAGGGCCGAAGCCGCCCATCCCCATCTTCATCCTC
+
@@;::DDDD8D?:CFG:CG@DFGH?HADE<?CG>DGG0@@@AEBBED;;?<>9(;@3>@<5??,>5<<?>B959<B?5<B99ABBBBB@94>:4>:>@B
@62O
GTCCGTAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFGHHGFJJJJIJJJJJJJIIGHHHJJJJJJJJJJIJJJJIJJJJJIJJJIJJJJJJGGJHHHFFFCEEDEEDDDDDDDDD?CCDADDD8ABD
@62P
CAAAAAGGGATTCAATTGCCATCCATTTAACTGGAATCCGACCCTGGCTCCTCTTCACGTAGGAATCCTCTTCATAAACATCTCGGGACAAGCCGAAATCN
+
CCCFFFFFHHHHHJJJJEIJJJJJJJIJJJJJJJJJJIJHGJJJJJIJJJJJGIIIJJJEHIFHHGHFFFFFFEEEDEEEDDCDDDDDDDDDDDDDDDDD#
@62Q
CTTCACATTAGATGCTGTCACAAATGGAGGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTCGAATTGAGGGCAGTCTGAGTAAGGAT
+
B@@FFFFFHHHHHJIIJHIIIJJJIJJCGHCFHIHIIIJIIJIJEEIIIJHHIICGHGGCEHHIFGFCDDDDCDDDDDCD@CDDDDCDCDCC:@CA>CC
@62R
TGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGN
+
@@@FBDDDHHHCFEEGGFCIHIIG<@EHGGHFGGGIIIFEEGIGEHGIIIGGHGCHIIICGIIIIGGDBBEFCCECECBBBCCCDCCCCCCCCECCCC@@#
@62S
CTCCAGACTCCTGCCCAAAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
@??DDADDHFHHHBE?F+AGGGGA;??@FDFEGHIIFBF?(@<8=CH>;BEGHEHECD@;7?;;@A;?B@??C>AAAC55>>AC>1>CC@D@BD@C@CCC#
@62T
CACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTN
+
@@@DADDFAHHDFFGHIHHG:CBGGCFCD@FDBD@BDB?BBGHDGI@F@DG;;DEEHH3?B@DFBAC@C;@>CACC;@@:ACBAC@>@?BCCA>AC9@CC#
@62U
AAATTTGCTCATCAGATGTGCCTCCTTCAGGAATTCAATCTTCTCCTGGTCTGTGGAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTN
+
@<@DDFFFBFDHHIEHEIEHGGCHGGEIGIB@EHIIIIIIIEGCGHGIGFGGEFGHIIIIIGHGIIIGAEC=@DHGDDCHHFHFHFBDCDFECDEECCCC#
@62V
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
CCCFFFFFGHHGGJJIJJJJJEHIIEGIJJJIGIHIJJIJJIIIGHIBGIIJJJHFHHJJIHIJJJHHHFFFFFFFCCECEDDBDDDDCDDD:ACDDCDD#
@62W
NCCCTGCTCATGACTGGTTATTTCTCCACTATGTAGAGGTCTCATTATTGTAGATTCAGGAATCACAGTTGATTGTACTCTCTGAGAACTATTTATGTACN
+
#11A;DBD>8:<DEEBBB<>>4@A4,<AD4+<A9<EDF):CB4:**?B<B?><9?49?<<<?39=@==))=))))/87).==;7)===.77773;);;@6#
@62X
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
?;?7;A?D<CFFB:F<EF@EGCCHAD*988?DF<GBD?:BDB9?AF(.<C9F=F)@E1@A=AAAEDDBDBA;(6;@B((;:<@BBA?<>@(+:@@4<?<
@62Y
GTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCCFFFFEHHHHHFFHEGIFHIIJJJJJJJJJJJIJJJJIIJJJJJJJIIJJJIJIJJJJGIJJJJJJHHHFDDDDDDDDDD@CDDDEEEDDDDCCDD
@62Z
CTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGN
+
:??DDDDFHGHF?DHIJGGIIGGIJJJJIGHIGHEGGGHIJJIIIIJGIIJGIJIGEHEGHHGECAEEFFEECEDDDDDDDDCCCDDDDDCBDD<>BDDB#
@630
GGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGN
+
@@<AD?>DHA<<D?E<:AC?<FHB?FGGBBEEFE?C:CFEHGGGH<'-8=C@HE.>A;6;B?DE56>AA@>>>CA:C<CC>C559@>@A>CC=CA>@>:@#
@631
CTCATGGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCN
+
CCCFFFFDFHHHHJJJIJFHJJJJIJIIJJGIJJJIJJJJJJJJJJJIIIIIJJJIJJJJJJHHHHHHHFFFDDDDDDDDDDDDDDDDDDEDDDDDDDDD#
@632
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
@C@FFFFFHHHGHJJJJIIJJGIJJJJIJJJIGDDFHIIIIIGIIJHHIJIIJIJJJJJJJJJJIIIE@GHFHFDCCCEEACBDDCDCCDCD<ACD@CBD#
@633
GGGCCTCTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCCTCCCTTTCTATAGTAGCTCGCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATN
+
@@CFFFFFHGFAFHGJJJCIJJJJJGGIJIJJJGIDHIIJHIJGHIGHIGGIJJIGCEEFHH<DDDBB>@CDECDCCCC@?BDBCCDD@BD>8@DCCCDC#
@634
CTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTN
+
<@@FFF@DFHHGHJFFHGFHHGIJIIIIJJJJJGIJIJGHGHEHJJJJJJGIE?EHHHHGHFFDDEFEDEEEDDDADBBDDDDDDDCC@CDCDBB09>@<#
@635
GGGTGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGAGGCGTTCTCTTTCAGCATCTTCACGGCCACCGTGGTGTN
+
??@+B@8BD;<?DFE<:+?499AF8BF=F*1::?D>3BAF;2(?8?;;AFFF;D7@E7(-,39??838(2:4>>>AA:AA:>AA>:?B30>@BB?<<B<+#
@636
ATCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGN
+
CCCFFFFFHHHHHIJIJHHIJJJJIJJIJJJJHIIIJIJJGHIIJIIJJJJJGIJ;CHFFD@BDDDCCDCDEDEDDDBDDDDDDDDDBDDDDDDCCDDDD#
@637
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGCAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTN
+
?@?=4B?D=C??FGEBBDHB@DF?BCFDBHC@FFGII8BD9?<D@GEEFIEB?88=DF<CFF'5:A?;@D3@C(;>@;@BA@@BB<3?1::>??B09BA3#
@638
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATN
+
;=?DDDEFHHHFDFFGHHII@FGHE?EFB?DGHCB>FGIEIIEB?F;CD=CAFHGFI@EGHFE>EFEC;BCC@>555;;@C5:>C@;>>?>:>>CCC?CC#
@639
CACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGGAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGA
+
@<@==AAD0@@CFBBGGBC38?@A>'3,88?<B@775733&)608>ABBBBBB078857&55(34>A3>B:+4:(++49B390?A>@9A?BBAABBBB?
@63A
CATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAA
+
:?+4=BAB?DFHDIDDGABHHGI>>??GAE@HCEBDFEGFDAFD<?BHGIEGDDGCHHIGGGCGHGHIGHIIGAECGE==A?>C@?>;;@>=?/9=:A
@63B
GTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGN
+
BB@DFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJHIIJJIJJJJJJJJJJJJJJJIGGIJJJHIHHHHHHHHHFFFFFFD#
@63C
TCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTN
+
???7BDDD???A:B:4,:<:<,:AE;1)+*11?9C80):6?DCD;@ADB>BB;1BA=((().===?AA>>7..);?);3>(.6((;A:1>AA>>;,5,:5#
@63D
GTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTN
+
B@<DDFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJIJIJJHFFEDEEEEDDDDDDCD>AB:>CDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@63E
CCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGN
+
@@@BDAA:CBBBFHDBDFE?@@/?C=CB=C@@FG<;5:;=;;?B@A>@C;5;A>@B;B7B8@@CACCCCCBBBB><B3>9B3:8<98<<@@89>B88<AB#
@63F
GGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTN
+
@B:BDFFFHHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJH:BDDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@63G
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFDFHHHHHJJJJJJJJJJGIIJGHJJCGHHGIJJIJIDGIIJJJJJJJJJJJIJJJHHHBFFFDEEDDEDCDDDDDDDDDDDDDDDDEDEEEDDD#
@63H
CTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTN
+
CCCFFFFFHHHHHJGIIGJIJJGGHIFIIIJJJIGGIIDHGIFIIIJIJJIGIJJGIJJIIIIIIJJGCHGHGJJIJHFHEFH@B@@DFFEEEECEEDED#
@63I
GCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCN
+
BCBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHIJJJJHHHHHFFFFFFEEEEEEEDD#
@63J
CGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGG
+
:B+4=BDFHHGHHJJJJJJJJIIFHJJIJJHHIJJHIJJJJJJJJJIJJJIIJJJIIJJJIIIFJIIHHIDGIIIIJJJJJJHHHHHGEFDDDCEEDDD
@63K
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTN
+
CCCFFFFFHGHHHJJJJJJIJJIJJJJJJEEGFIJIGBGHHIJJJJ@GIJHIGIGJICHHHFHDEDEDCEDDDDCDDDDDDDDDDDD@DDDDDDCCDEDD#
@63L
CCTGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
?@8=4B?:ABFF?G@GFF?:CFC@HFCHIF?9CHDFI3BFFF7DG=GDDEEGFFE@9BF<=;A'5=9BBB;@@>6;>9?5'55<@A(5<?BA>AA439@A#
@63M
GTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCN
+
@B<DFFFFHHGHHJJIJJJJJJJJIJJIGIJIJIJJJJJDDDDCDCCCCACDDDEEECCCDCCDDDBDBDDDDDDEDDDDDDDDDDDEDDDDDDBBBDCC#
@63N
CTGTCATCTCCCCACATGGCTCCTGAAGAGCCTTCCCAGGGCACTGCTAAAGGCTCCTTCCCTTGAGGAAGCACTCCACGACCCCCTGTTTGTTGTCCTTN
+
@?@D=DB?:ADDFEAE:AD@+C@DECC9C?;E@?<;?D?:D=DDB83DA@F@<8CA@C=FF@AE>;AE==B?>>BC6(6=BBB8@;<<@ABB<?<@4:AB#
@63O
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
B@?DDDADFAHHFGHGIJHIJIJIJJJHGGFHIIJJJIIJIJJJIHGGHIJJJJJJJIIJIIIHFFEFFFDEEEDEDDDDDDDDB<BDDDDAC4>C>CC
@63P
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTN
+
:?:AADEFHHGGFGJJJIGGHIIGGEGEGEDHHGHIIJJJIEHIIIJDDFGDHHGGIGGHIGGGDGGI=FGGGHAHGIJJIJJJICHECHFBFB@>;AED#
@63Q
ATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGN
+
?7;B12A;AC8+CBD@3<<CD?G>FCGB3?C<FEFBDFGE9D9FFG>GI@>D?FAB)=BC=FFA;7CDFEE>E;B?D@?>=5;ABBB,9::5::>:33<5#
@63R
GTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTN
+
@@:DDDDFHFHGGJGJIIIJJIJJIJJJIIIIIJIGHJEEIIGIIIFHGJIGIEHGJIGGEHGDHGHHHFFFFFEC>ACBCDDDDCCDCC@CCCCCCDCC#
@63S
CTCCTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGG
+
@C<DFFFFHHGHDHIJIJIJJJJJJJIJJIJIJIJJJJJGGGGHJHHHGGGGIJJJIJIJIJDD>BDDDDC?CDDCCDDDDBCC9?CCDDADE>CCDDD
@63T
CGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCN
+
=8?4A@DAC:3AD>ACGF4CHE>EFBBGE<CFDAFGEFEABB@@DFFFFBBBBCEFF@AD7==CF>>>35;BDDDB>A(;?@B?8?:;@8AB58A@>@DB#
@63U
GTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTN
+
@@;4ADDDFBDFDBHCFHGHIIHEHGGGHBBGHHGE;FD0?BDFGIIIEGGIIG@CECEEHHF=?DEEDECCCAA>@@@CCECCCCCCCBBB>ACCCCCC#
@63V
GTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATN
+
C@@FFFFFHHHHGJIJIIIIIHJGHHIJIIJJJJJJJJJGDHJJCGHGIJJIJIIIHHHHFFFFEEDEEEECDDCCDDDCCDDDD>CDCDCDDDDEEDEE#
@63W
CTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
CCCFFDFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJIJHIJGIIGGHIJCCHGHHGIGIFHIJJJJIGHHHFDDDFFFE@ACEAC;ACDDCDDDD
@63X
GTTCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
:?+=ADDAHDHFHGGBFHAFHIIEGH@GCGDGHIIIGIIIGBFHIIGIFEIGCHHBD@HH@EAC@EA>C<BECEEDCACCCACCCA=,5:?>CBB8??B
@63Y
CATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGN
+
????AADD<?FHHEEB:EGFFEFDHGHECFFHEFDFHDEADHFDBBB@FHGD;=CB=CGIH=EC@EEEC????@@?A>>A>>C@;;@@=-98?CBB>::<#
@63Z
CGTTGAGGGAGGGAAGCGGAAGTGGCTACCACCCGACGGCACTGGCGGGGCACTCTTGGGCACTGCACCCCCAACCAACCCCACATCAATGAATGGGTA
+
@@=DDFFFGFHGH@HIJIJIGIGHHIGIGIIIJJJEGIGGFFEEEDBBBD&023+3(3>B89<<>3((9?DD-(+58?()9@850+4>C@3(>3:AB+4
@640
GCAGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGN
+
:=144?DBFFB<::CEGB:CGHHFIIFHECFIECCFGEFFEBBFDFIFEEEDGC=DDFI5@C>@D>EFE;?>A;7?@.??;;639=@B@5<5ADB@A<@>#
@641
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
=@+=BDDDDFHDFGIIGHHHHIGGIIJBHHGGIBGFHIJIJJIJIEGIJ@FEHIEHBFHIGGGHGIJJHHHF?B95<9@CC@9@9@@@CDDDDCDCCDD
@642
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCC
+
C@<DFFFFFFHDDHGIJIGGIGIJGIGIEGIIGEGIGIJIJIGGIGIBBHGIJEGHHHBEDEEDDEDEEDDBDDDCCCDCCCACCDBDDDDCCDDDD
@643
GTCAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTG
+
?=+BDDDDGHACFBHGGHEFF:FEFHGGCFGIFIGGEGHIEHGGIIIFHIGGFHIIIIBEEHEGIIIIIGIIIIHBDE>AA=BDCB@BDCCDDCCCCC
@644
GTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCN
+
@B+BDEFFHHHHHHIJJFHJJIJJJJJJGIJJJJJIJJFHFHIJJJJJIIIJJJJJIIIJJJJJJIJJJIHHHHHHFFFFFFEEEEDDDDDDDDDDDDDD#
@645
TTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCN
+
@C?FFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIIIJFHIIIJJJJJJJJJJJJJJHHHHHHFFFFFDEEEEFEEED#
@646
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@@@FDDFFHGGHHJJIIGJJJIHGHEIIJJJGIIEGFHGIIJJIIJFHGIHIEGIIFHHEHIJ;ABE9@@@ACDCCBBBDDDBBDCDDBDD9C@CA>CAC#
@647
CGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCCCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACN
+
8?<?:DB:C?:AFG@@FD?AF><A;?:8)?0)00909B?7C17)88)..).--5'',..6.-5@;@>:=/=85((+4:>39:AB(>@3>B?8+993(>:2#
@648
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCN
+
@<@ADFFFDHDDFCGIIIDG@CFEGGFGGEHIIIIB@GIIIIGEBFHGEFAAHEHIICGFFHA@=CC@DCECH;=B.;?);?C>@C@C@CCCCCCD,89A#
@649
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
BC@DFFFFHHHHHJJJJJJJJJJJCFGFHGIJHIIJIJJJJJJIIJJJJJIJJJHHHFFFEDFDDEDDCCDDCDDDEEEEDDDDDDDDDDDDDDCD?ACD#
@64A
CTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
@B1DDEFFHHHHHJJJJJFHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJFHJIIJEHHHHHHFFFFFFFEAAD;CCDEEDDDDDDDDDCDDDDD
@64B
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCN
+
@@@FDDDFHHHHHGGGHHIIHIJGGIHGHHJDGEIIIIIJGCFHHGGHGGIJJIIJIJJJHGHGHIIHEEHHHFFDD@@CCACCCDACCD?ACCCCCC>C#
@64C
TGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
@@CDDDFFHHHHHIGJJIJGIJJJJIIJFHJJGIJJIIHHGIGHHIGEIIIJJDHIJGGGGGGIIIHHEAE@BBEC7>CEDDD3=BD<CC@DDCACDB
@64D
GACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATN
+
@C@DDFFAACC:CFBGGEBHBHCCEECEHGBDFF:?DBGAGFFHIDE>F@8BDB@4BFBEHG;FH@GIGE>A=C;CA=A=?C@CFBC@C@3>@CCA;335#
@64E
CTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJHIJIJJJJJJJJJJJJJJJJIIJJJJHIHHHHHHHFFFFFFFEEEEEEDD#
@64F
CGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTN
+
BCBFDDDDHGHHHIJIHJJGIGHJJJJIIJJJIJAGGBFDFHIFEGIJIJIIJJJIIICHH>EEHFFF@>BE@CEAEDDDCDDDD><C@CCDD>CCCDDB#
@64G
GGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTN
+
CCCFFFFFHHHHHIJIJJJJJIIJJIJIJIJHIJJJJIIJJJIIJJJJJIJJJJJJIJJIJJHHHHHHFFFFDDBDDDDDDDD>ADDDCDDDDDDDDDBD#
@64H
GTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTN
+
?:?ABDEEDDDF?CBHIIHHIGHFGHGHEGGHI6D8?FA9BGFFEHCE@@FHGG7@E@EHHHEEFCDEFCC@@@C;@CCCDDDDDCCCCDD>9A:@CCCD#
@64I
GCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
?7<A?D@D8A<BD@8@EC3<CA>4CACE@EB<41:CDA<D<<BDE<DBD>49BD4??CD:8546;;;??@@A;;AA3>>>3>>;A?(5>9:>>AA:>><
@64J
CCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATN
+
CCCFFFFFHHHHHJJJHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJIJJJJJJIJJJIJJJJJJJJJIJJJJJJJHHHHHHFFFFFFFEDEDDE#
@64K
GCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAAT
+
??+:=B;DB?<DFEBF>B>CFEHEHF>HEAHF@@ECBEF>BDDE>DFEACEE@B<DFAFGFGEIGEFBE=CFIAA<C;@D;B?B>;;ABBB;;(-;5;3
@64L
CTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGN
+
?@@DFFFFFFDHFGIIGEHGHBHIGIFGEGDHGGHCGGGIIIIIIIEHCEDHHHIIIIIIIIIIIIDGCCE;=CHDDD?CDECCB;?B=9CCCCC@+:AB#
@64M
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@C@DFFFFHFHHHIGIIJ<FGIGHIIJHIDGIIJJJJJJIIIGGIJGIGGHJJHHHHHHFFFFFEEEEEEDDDDDDDDDDCDEDDCCDD@CBBDDDDDD
@64N
TGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTN
+
@<@DFFFFFHHHHJGHIGGEEGHGHGHEHIJ<DCDHHGHEDH?GH?DHEHGICHGG@CFFCGIIIII@CAHFEF@C@CEAABBDCDDDDDD?CCB>C@B+#
@64O
GGGGATGCTCCCTTGGTGAGAGGCTAAGATTAGGGGGGAAGACGCAAGCAAAGTTGGAGGGTTCCTCATCCTTTTCCTATGCTTCCTTTTTCTTTTGCTCN
+
=??++=A3CDD?++22AECFII18<+1@*?**1*)))&)&(((&&&))((((39((:(9()+(+((4::(4+(+(+((((+((+4(((4(((+4((((+4#
@64P
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
@@@FFFFDHHHHHJJIJJIIJJJJJJIIJIIJIJJJFHDIJGIJHHIIIGHHIFGIIGHHI5BGHHDHFCEF;ACEE@CCDDDBDDDBDDDDDDDDDDDD#
@64Q
TCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTGTN
+
@@BFFFFFDHFHHJJJJIIJIJIGEGHIIGGEDDBGGIJIJGHIIIJHGIIIJJJHHJJJJICEHHHECBDBCFFACEEEDCCDDDDDDDDDDDDBDDDD#
@64R
GGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGG
+
@C@FFFFFHCFFFGFIJJJJJIFHJIJIJJJJJJJGIJJJJJJJJJJJJJIJIHIJJJJJIJJGGIJEBHGIHHHHFHFFFFEDDEDDDDDDACDDEDD
@64S
CTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCN
+
CCCFFFFFGHHHHJJJJJIJJJJIIJGIIIIJIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJIHHIHIIJJJHHFFDAEDEDBDBDDDDDFEDDD#
@64T
CACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAAC
+
@CCFFFFFGHHHHJJJJJJIJJJJJHJIJJJJIJJJJJJIJIJJJIJJJJIJJJJIJJJJJJIJJJJJHJIJIJHHHHHFFFFFFFDEDEEDEEDDEDD
@64U
CTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIIJJJJJJHJJJJJJJJIJJJJJJJJJJHHHHHHFFFDDEEEEDDDDFDDDEDDDD#
@64V
GGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTN
+
@@?=D??DDDHFDHGHIGD>HHEAHEHEHIIGHGHGCCFGHIIICCGIIIIIGHHGICFGBBGGICEHGA@C@HH;=AEHHHHEEEBBCCCCACBBCCCC#
@64W
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@BFFFFFHHHHHJJJJJGHIJIIJJJJIFHIJIJJJJJJJJJJJJJJJIJIJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDCDDDBBDDDD
@64X
NCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
#114ABDADD?D>8?BEB@AEF@BB?CE@@B)?@DECCDEDEC@@D?DEDE9B@;CC=CDAACDD=@DD16>(;>A35;>>???>&09((4>(3(+:(+(#
@64Y
TATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTN
+
@@@FDFFF?DHBFEGCHGEGII>GGGHCGHDFBFHIIGED@C?:?BGGADBH?BEHIIIIIC@GG=CGEGE=C@DE>CEH@@CB@@;;>>C6>=AAC@AA#
@64Z
CTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATA
+
B@<DDFFFHHHHHJJJIIIJIJJJJJJJIJJJJIJJIIJIJJJJJJJJIJJJJIIJJGGGIJJIIIIGHEHHHFFFFFFDCE(>CCEDDCDDDDEDEDD
@650
TGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTN
+
@@@DDADDDHFADDFDBAAC<FHCHF;EE@F@GHIGGBG<G<DFDFDHDFGHBF3BC=FHC)=7=CGI@;?=?;A@B>=A@;>?AA>>C@>?A:>=B555#
@651
GTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAA
+
CBCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJIJJGJJJH?CEHFFFFFFFEEDEEEDDDDDDDDDDDDDDDD
@652
AAGGACCATAAAACGTTGCCATCCGGGCTTTATGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGC
+
<1:B72A?DFA<4C8A:CGB4:CA?EE0?=@0*:*?<F*?D40*9??@)8).)/))=DF3.5))=)7.7?>@);;>>;365(53>@;6@@B>3>;>3(
@653
TGCTTTCTTTCCCTCCAACATAAGACTGACGCATTAAGGACACCATGGCCTTACCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATA
+
@C@DFFFFDHHHHJIJJJEHJJGJIIIIIGIIIGGJJJIIJJJGIIJIIJJJJCHIGEHJJJDHIJFCEFFEFEFFDCCDDDDDDDDCDCDDDBB?>@
@654
CCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCN
+
?@@ADDDDFGGHHIIIIIHIIIIIIIIIDHGIIIIIIIBGHIIIIGIIIIIIIIIIIIIIII@GHEHHFFDFEEECEEECCCCCCDFDCCCCCCCDEEEC#
@655
CACAGATCACTGGGATGCCCTACGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCN
+
@@CFFDDEFHAHAGEEGGEGGCEEF;?:C**:<?C?D?:B@FHG@FGHJHJJICEEE;BBF@FA;.5=BEC'6@>?@CBDB=>>A?C@A:>:<CCBB3:9#
@656
CCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATN
+
CC@FDFFFFHDFDGEHGHIHIHIJEIGGEDHGAGGAFFHIBFCGCHIHEHHFC@DDBBGEEGGIEGHIIIHGGIIJIEGE9CEAD;BEDFACECDEDBDD#
@657
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTN
+
CCCFFFFFHHHHHJJJJHIJJJJJJFHIIJJIJJJJJJHIJJJJJJJJJIJJJJJBFGIIIJIIIJJIJJJHHGEHEFFFFEDDDDDD9@@CEDDCDDD@#
@658
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
@@<DDBBDF8ACBDAEGHIHADE<CFHFEGGFGBC?DFHCG@GGGED>DGFEGEGGAEEHDEHDEEEE;@CCCCCCCCCCCCCCCC?BB(+:CC:@CC?
@659
CATGTTTCTGTTTCAATTGTTCAGAAAGATCTGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTN
+
@?@D?BD?DFFFDBG:ACFA@EC>:F?<CEF?B9CGHEFHG<<?49<HGC>F@F?BGGHEHB8@FGF=;CGHIIIE@EE=C>;5;BDDBDE6@CDC;:>?#
@65A
CTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTN
+
@CCFFFFBDFHHAHHIJGIJIGIDGIJEHCCGEIEIJIJJJJAFGIIIIEHJIHHF@DEACCDEDCCC>CBA@BDDDDBBCBDDDCA?CCBD@CCDDBD9#
@65B
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
CCCFFFDDDHDBFHGCFGIGHHJJJIDHGIJJGEIGIIIGGGHIFIJJEHGIJGIIGEHIHE;ACE@DFB@CCCDEECDDCCC?CDCCDCCDB?>?BD(5#
@65C
CTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCN
+
@CCFFFFFHGGGHIIGHIJIJJJGIIJIIIGIDFDDDDD?CACCDCDDDDDCCCCDDCDDAADACDDBBDDDDDDDBDDDCCDCB@BCACC::@@?CDCD#
@65D
GTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTA
+
@@@BDB??DBHDDCBEFH@;FE@HFF?HAHHB9?F3:D9DFHIIIGIIE39???9?FCCBFG@@;FFCC7=D=CHEE;3)?C;BEEEAC@AB?;A;;@C
@65E
GTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
B@CFFFFDHHHHHGHJIJJHHICGHFHIJJJJJIGIJJJJJJJJJJJJJJJJJJJIJJIJJJJJJHHHHHFFFFFDDDDD
@65F
GCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAAC
+
CCCFFFFFHHHHHJJJJJJJJJJJHJJJJJJJJJJJGHIJJJIJJJJJJJIIJJJJJJJJJJJJJJJJIJJIIJJJJHHHHHFFFDFEEEEEEDDDDDD
@65G
CTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCC
+
CCCFFFFFHHHHHIJIJJJGJJJJIJJIJJJJJJJJJJGJJIJJJJHGIIIIJIJJJJJIIJJIJIHHHHHHFFFFFDEEEEEDEDCDDBDDDBDDDDD
@65H
GCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATN
+
@@@DDDDDHHBBC<A?EFHDCFGGDBFFIEAAEEEDHI?EC@HGGGIC?@GDBHEGBB?F?B=F=BBCDCGIIII=AH=)?E9B>9<A@ACDC@CCCC:A#
@65I
CTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTN
+
;@@D=:ADFDFDA>@<CHHCFHEA<?EC<FFGIIII>DDH7C0)??BB??BBFEBHCCH<48=C@(;=BG=69;?BBCDCC>9>C>@4>:>38?C>C>B>#
@65J
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
<@@DADDDHDDH:EEHGHHB@HGHIIIF9CFEEGIIIIIIIHIEGEGICHIGAHHG@DHFHFFFDECCCCACCCCBB'8;5ACCC>@?BB@?ACCCCCCC#
@65K
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCN
+
B@@DFDFFHHHFHICFHGHJJJJIJIIFJJIJGGIIIIIJJJJIJJIJEHIEHIJIJIAGHJIJJJIHHFDBBDDDDDDD4?CC>C@DDDCBCDDD?@BB#
@65L
ATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGG
+
CCCFFFFFHHHHHJJIIJJJJJJIJJJIJJHHIJJIJJJJIJJJIJJJJJJJJJJJJJJJJJJJJJJIGJJJIIJIJHHGHHHHFFFFFFEEEDEEEDD
@65M
AAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAA
+
??<DAABDH?DB?ABB>FHHDHGGH9EA<?CFBHGIII>*?@FCBDDDDDHEFFGCGHE<8DDHBBFHBHGC=FH:7.7@@CC:A>EE;;@B>B36(;
@65N
TCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCN
+
CC<DFFFFHDHHHGIJJHIGHFHGIJFHGGIGGIGGIIGIIIHIGDIIIIIIJGEGGHHJHFGHFFFB;ACEDEEADCDDDDDDDCDDCCDDDDC>CDDD#
@65O
CCTTTTTGTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAAGGAAAAGCGC
+
@@CFFFFFFHFHFIIJIIIJJIJJJGGIIJIJJIJGIJJJJIIGGGHJJJJJIIIJIGGIIJJJGIJGIJJJ@@EGIHHHFHFDFFFDDDD?CDDCDDD
@65P
GGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGG
+
@C<FFFFFHFGHHIGIIJJIIJJIIGJIIIJIJJJIGCHIIIFHIFIGGDHGIGGACHIGEHIGIIGIIIJIIJHHHGHFFFDCB@@@DECC;>CDDD
@65Q
CCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTT
+
<?@DDFDDFB>C?G@@EH@FEHIAFGGGFGHGBFHB@BDFGIIEEHGI<??DHGDD@=CFHGG@@>EEEEECH@E;?@DFBDEECCB>=CCBC?<:>AC
@65R
CTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATA
+
@C@DDFDDDBFHFIIBFHBHIHIIBEHHGHGEHIIIIIIIIIGEHIIGIGHIIIGDBCFGIGBHIHCCECHEEFEFCFFDCC>AACDDCCCCDCCCDDC
@65S
AGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCN
+
@C@DFFFFHHHHHJJJIJIJJJIIIJIIIJJJJJEGHIJIIJIDHGG@FGGIIJIIIHHEHHFFFDDFEEDEEEDDDDDDCACCCCDDDDDC@CD@CCBD#
@65T
GTCCTCTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTGCTCTCAGGCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJHHHHHFFFFFEEEDEDDDDEDDDDDDDDD#
@65U
CAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTN
+
@CCFFFFFHHHHHHIJJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIIJJGHHHHFFFFFEEEEEDDDDDDDDACDDDDDDE#
@65V
CATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGN
+
@@8D<??D?FDADFE@F:<:C+<C1?CEB;BC@@BF>3*BBFF>=@FF<F@=7@7.;@;?EAB)7;@BC693',5>>B5@?<@B<44>@A:4(4:(:<?5#
@65W
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
@@@FFFFFHFHHHJBGHIJIG@GIJJJJJJJJJIJJIJJJIJIIGGGIGIIHEHFHHFFFCACDDDDDCDD?CCDCCDCCDDDDDDDCDCDDDBDCDDDA#
@65X
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
@@@D=?BDFDDDHEF:C?FGDFCHHHGIIIIIEDBHBBFHGIG@GFI@DHIB7=C>7?AEEFFDEEEEE>ACC>CCCDCCCDAC>CBB?@@?CCCDCDD>#
@65Y
TGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACN
+
@??DDDDD<DDDDHBHE?EFEBHHBHEHGHEEHGGCBF@BDBFE@@:BBDGHC)74AFC5;??EE?CA@;@7?@65=35@CD@ACC3>?<??5>C@:>CC#
@65Z
TTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTN
+
==1ADDDBBCFFF?@CFBG>FHIIIIIG<H?DFBHI@F08B?DFBFE@B8B6;=====DGCEEECCBB;7;C6>===?;?CCC5@A:>C>>AA3@4::C>#
@660
CCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTN
+
CC@FFFFFHHGGHIJJJJJJBGHIIJJJIIIIJJJJIHGIIIIIJJGIJIJJDFHHIG6BFHHIJJIIHIIJGHHHHDB;@C@C@CDDDC@ACCCCCCDC#
@661
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
CC@FDFFFHHFHHGJIJIIIEGHJJIIFIIIJJGFGHHIIJIEGIIJJJIIJHHHHFFFCDDDDDCDDDDCCDDDDDDCDCCDDDDDBCDDC>CDDCCC
@662
TGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGN
+
@@CFFFFFHGGHDGIJIIHIGIHGHIIIGIJJGCHIJJJIIIIJJJGHJIBFHIIIIIHIEHEHEHBDDEFFDDACBCCDDDD@BBCCDDDDDCACCDCC#
@663
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
??;DDD++=CCD72:CEEEE<@;ACF><CCED1@D:C9D@D@@9??B4?DEC8*?D?8BD>CC9=@4.=CEII.:<'7@;;AA@;A;3>AAA:(,:<9=?#
@664
CGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGN
+
BB@FDDFDHHGHHJJJJJJJJJJJJJIIIJGHIIJJBGHIIJGGHIJIIDHIJHFHHEFFFFFEEEDEEDDCDDDDDDDDDDDBDDDDDBCDD:@8?BDD#
@665
GGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTN
+
@@<BBDDAF?DDBDE<CFE<F=HE@@BDF@):?BDHCGGFABFH?GGGGH@75;CEHIDGFEF=BC:?CE?A?';C;>;>CCCA>3>@CAC<@C@CCCE:#
@666
CCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGAAGGATGGAGGTGCAGTGACTGGCTN
+
@@<DDDDADDDFD<EFEAEHEAC:CA??FHHECGEGFIIFFFIIIFFFFFEFFIG@FEC@=CFFGII==@A;CFD/;;=>ABBA@@<?ABBABAABBB<@#
@667
CTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTN
+
@??BD=D?A??BDFGBFHFIG;??FBC?C?CF<C@::?BB?D9DHIGIIFBGA;FHIGAGD@=D;6==EBB339CC->5@(;@::CA989<?4>CB??84#
@668
TGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGCTTCTG
+
BB?DDFFFHHHHHIJJJJJJJJJJJJJJJJJJJIIIJJJJJJJJJJJJJJJJJIJJJHIHIHHFDDDBDDDDDDDDDDDDDEEEDDDDDDACDDBDDDD
@669
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFFFFGDDCFHFHIIJJJJJHHIJGIGJJJIJJJJJJIHIJHDHIIHIJJIGGGHHGHHHFFFFF@A>BCD;CC>CCDDCDDDDDD(>>CACDDDD
@66A
ATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGA
+
@@CFFFDFHHHHFHIJJJJJJIJJJJJJJJGHGHJJJIIJJGIHHIIJJJJJIIJ@GHGEHDHIGHHHHFFFFFFDEEEEDDBDD@CCD?C@ACBDDD
@66B
CCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCCCTGCCTCTTGACTGGCTTC
+
CC@FFFEFHGHHHJIEIIGJJJJGHJJJJIJIJIIIGIGGIGIIIIIJJEHIIJIJJGIIIJIIJJGJGHDHGHIHHGHFFFFFFDEEEEDDDBDDDD
@66C
CTGGGAAGGTACATTTTCCGCCATCTCGTAGAAGATCATCCGGTCAAAGTTGCTCGTGTGCTGCCATTCCCGCATGGCCCGCCACAGTCCCTCCTCCAGGN
+
CCCFFFFFHHHHFIJJJIJJJJJIJIIIGHIJJJIIIJIIIIGHIHJJIGHIIIJJIGGIHHHHHFFFFEFDDDDDDDDDDBBDBDDDDDDDDDDDDDCD#
@66D
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
=?@DDDADBFD?DAHGIEGCHICEDHHIGI9FGHDCCCGIHFCCGHBHBBFEHCHGGGEHI@FEHIICHAHEEHEECEC7=A8@@CCCACDC;ACDCC
@66E
TGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTN
+
BC@FFDDDHHHHHJIJIHIIJJJGJIIGGHIJGIJJJJJJJIIGIJJJJJIIJIIJJJJJIJJIJHIHHHHHFFFDDDACCDDDDDDCCDDDDDDDDDDD#
@66F
CTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJFHIJJJJJJJJJJJJJIIJJJJJJIIJJJIJJJHGGJJIHIJIGIJJJHHHHHHFFFCDCCEDDFDEE#
@66G
CCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTGTTTTTGGGGGGTTTCTCTGTAAACCAGGAGCGGTACGTTGGGTTCCACA
+
?;1B?:?+2AC:A@C+:3A<)2<<:)*:?9C@AD44??@:B**9*90/*98)9BAD4AA3&)+:A:(4:>4:(9<<>8(+&0&)09<<8<>+8<A44:
@66H
TTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTN
+
CCCFFFFFHGHHHHIIIJJFHHHJJJJJJJJJIJIIHIJGHIHIJIGIIIIJHIIIHHFHGFFFFFEEEECEDDDDDDD8@ACDDDDCDBBDDDDDDDDD#
@66I
GCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTAACCTGCCGCCTTAAATCACN
+
@@@DDDDA<CDDDGHGIGIHC<AHHCHHIGGGIGIE?FGI9?F@GGGHHCGGIGGGIE*8=FDGEBGGAGGGGCEGC@CEHHEC>2@DACBBBCCCECCC#
@66J
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCCGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
@C@FFDFFHHHHHJIIJJIJJJJIJJHHIDFIJJJJJJJGIIJJIJJJIIIJJJJJJIJIJJIHHHFFFDDCDDCDDDDDDDDDDDDDDDCC>CDDDEE
@66K
GTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCN
+
@=?DDD;DFDHHFFFADGHHEFIEHGDCH?C>??CDBFCDDHEDFHHI<?FGGEHII@6C;EHEDC=AEB@A@AACC99@CCC@CDDDDCCDDCCC4@AC#
@66L
CTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCN
+
CCCFFFFFHHHHHIJJJJJJJJJJJIJJJJJJJJIIIJGGIIJJJJJJIJJIJJJJIIJHHHFBECCCEDDDDDDDDDDDCDDDDDDDDDDDDDDDEDED#
@66M
AAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGN
+
?@@:ADFBHHDFFIJIIGHGGHIJEGGGGGED@FFHIIHBDDDCFBEHHEGGH@AGIIIH@ECECHEFDE@>BECCEEDD@CCB@?B8;/?>CCCDDDDD#
@66N
AACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACN
+
@C@FFFFFGGHHHJIIJIIIIJJIJJJJIGHHHIJJJJJIJIJJJJIBIIIJJIJIJJJJJJIJIGIJIIIFHHHIJGHHHHHFEFDEFEDEEEEEDDED#
@66O
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCN
+
@@@FDADDH?FHGFHBFG@<GBBGCHIIIF@F:?DHGI?BB9?DGAHIGIIGI@EGEHICE>EHEFDB7?CCBCBBCCCDCCCCCCCDECCC5;A:CCA@#
@66P
CTGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAG
+
B@@FDEFFHHHHHJJJJJJJJJJGJJJJJJJJIJIJJJJJJJIJJIJJJJJJJJJJJJJJIIJJJJJJJJJHHHFFFDEEEDDDCDCDDDDEDDDDDD
@66Q
ATTACATGTGGGTGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGAGGCGTTCTCTTTCAGCATCTTCACGGCC
+
?@;BDFFFADBHHIIIIGGCHIIIIIIIIGIIIIIIIIIIIIGIIIIIIIIGIIGGIIGGHHFFEFFCDBBDBBDB@DDDCDCCDDDDDDCCDACB<BD
@66R
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
CCCFFFFDHHHGHJIJHIJJJIIJJIJJJJJJJIJJJJJGIIJJJJJJJJJJIJIJIIJJEIJJJHHHFFFFFFEEEEEEDDDDFEDDDDDCCDECDCDD#
@66S
TGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCTGTGCATCCCTCTGGGGCTATCTAGGGCTTGCTCCTGCN
+
CCCFFFFFHHHHDGIGIJIIIJJJJJJJJJJJJJJJJJIIJJJIJJJIGIFGHHHIIGHHHHFFBDFFECECCCDDDDDDDDCCDCDDDDDDDBACDDDD#
@66T
GGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCN
+
CCCFFFFFHHHHHIJJIIIJJJJJJJJJHJJJIJJJJJJJIJJJJJGIJHIIJJJIJJJJHAHHHFFFFFFEEEEEEDDDDDDDDDDEDDDACDDEEDDD#
@66U
CTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGG
+
@@@DFFFFGHHGFGGBHGFGIGHGJEHGJIGA@FF<DFGGGGG@GIGCHIHG>F@AB?;EDF>BDFEDDDDDDACCDDD<CCDDDB?BDDBBDDDC?B<
@66V
CAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTN
+
B@<DDDDDHHHHHJJIJIJJHIJJJIIGJGCHJGIIIIIJJJJIIJGIIIJIIIIIJGFHGHFDFFFCDCEDDDDDCDDD8=B9CDDCACBBDDDDCCDD#
@66W
TTCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTN
+
@C@FFFFFHHHHFGFHGJJJJJJIJGIIGHIIJJGIIFIIGIGGHGGGGIIJHJJJIJJJJJGIIJGGHDGHGGI@CGEEEEHGFFFFFECEE<ACCDDC#
@66X
GTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGN
+
B@@FFEFFHHHHGJJIGIHIJJJJJJIJJJJJJJJJJJJJJJJJIJIJJJJJJJHIIJIIIIJIJJJJJHIGHIJJHHHHFFFFD9??BDDDDDDDDDDD#
@66Y
GGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTN
+
CCCFFFFFHHHHHJJJJJJJJIJJIJIJJJJJJJJJJJJJJJJHHHHHHFFFFFFEDEEEEDEFFEEDDDDDDDDDDDDDDDDDDD@DDBDDDDDDDDDD#
@66Z
CTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTN
+
@@@FBEFFHHHFHGFG?EHIIIIIIIIIIIIIIIGIIIIIIIIIIIIIGIIIIGIIGEGGGIIIGFHFFDDEECACCDCDCCDDCCCDCD?CCCDACDBC#
@670
CCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTN
+
@@@FD<DDADAHFGGEGDHGGD>EEGHACEGIIDCEHCEHIIGGIGGIGAEDCGAGICGIIIHEE?EEF@DFFD;;ADCCAB;B??AD>ABC>CBCDDC:#
@671
GTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTN
+
@@@DDDDDFHHFFGHJIIIIIJGIIIIJIDHCGIJJIJJIIJIIIIIJGHIIJIIIIJIIHEAEHHGHHFFFEFDCEDDCCCDDDDDCCCDDCDDE@@CA#
@672
GGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTN
+
@@=DFFFFHHGFFGIIEHDGHJIIIJJJJIGHEHJJGIIJJJJIGEIJJJIJJFJD@<<CDDDC<A>ADEDCBCC>A:ACB<BDB?ABDDCCDDDD:>CD#
@673
CCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGN
+
=;@DD;DBDD::AFHAE<CBHEFBBGFHHCFGBEGCGD@FEFHCCFGFGIBFF@CDCCF=;==CCCEHEEEA>B?CCDCC9<??B?BACD>ACCCCCABB#
@674
CTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTN
+
@@@DFDDDHHHDBBGEDBEHHBFGHGHIE@FGGGEG?EGGEHIBHEFHHEEBGFBEHCFHEIIIB@EFGBAGIBAFH;@@GHCBD59;;A>BCDEACCAC#
@675
TTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACN
+
@@@FFDFFHFFFHJIHEHGGIIGGHGGIJGIJFHIIIGDHIGHHGEHIIIGIIJGIJJJJIEHIIGHIGGCGHGEEHHHFFFFFFDECCCEECC?ACDCC#
@676
CCTGGCTGCAGGCCCCATACAATTTGATGACATGTGGGTGGTTGACCTGCTTCAGGACGTTGAACTCTGACAGCAGGTCTCGCAGCTCACTCGGGGGGGCN
+
???:DDDDDDD:C<<E:?F>FE92ABECEAEDDC1:?DD::D6(BCADB@7@DACAD<A5;6;?;?AA;;>6>??>?5>>>A???;>:>::42+5.&059#
@677
ATGGGAATAACTGCTCGAGGGCTTGGATGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATN
+
+=?DAD8DD<CA<@?E=13@FED8E7*9?8?BBD@<B@<@B?BD<B.)88=BACCC>@:35;5?5;(>@:>A6(;(;35;-,(:>395;;><>AA>(8<A#
@678
CCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCN
+
@CCFFFFFGHHGHGIGIIJJIIJJHGGIIJGIIJJJGGGIHHGHGHIIEHGIIJJJIIICHICHIHFHHIIIGIIIJFCHHHHHHBDFFCDDEEEECC>@#
@679
GCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCN
+
BCCFDFFFHHHHHJJJDDDDDDDDDDACDDDEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDBDDDDDDDDDDDDDDDDDCCDCDDDDDDD#
@67A
CTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGN
+
@;@DDDD<A<:DFEIIFBGIIIFFCFGFFBFFEFEGIIEFCFBEFFEECBEDDCCCCCA@B@BB?@B<?ABBBBB>?BBBAB@BBBBBB?<5>B9>:@BB#
@67B
GAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTTGCTGGGN
+
@@?DDDDDDB<FB<CFHBEGCBHIBFEEHI;C?FBGH<DCBD@GGC@FEAHEBEEDDDBCCAC@@@ACCCBCACCCCC?CCACA:9@@B?CCCCCCCCCB#
@67C
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
CCCFFFADHHHHHJIIJJJIJJJJJJJJJJJJJJJJHHIIIJIJJJJJJIJJIJJJJIJJJIJJJI@FHBEFHHHFFFFFFFEEECECDDDDDDDDDDD@#
@67D
GCCCATGCTACTGGGGTGGTCCTGTCGGAATGAACCTGAGGAAAGAGTCACATTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTN
+
@@CFFFFFHHHHHJIJGHHHIJJJJJIJJJJJJJIIJJIJJIIJJJJHIIAHIIIIJJHHHHFFFDDDEDDDDDDDDDDDDDDCDDEEEDDDDDDDDDDD#
@67E
CTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGN
+
?@@B;ADD?@+2<8CEDDB;81CGFFEAGBF;DF>FFCFFFIEICC7@FFEEFD9?@B;BBAAA@<+4::>BBBB55?A:A?:>>BBE3+::A<:3><@<#
@67F
TTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGN
+
@C@DFFFFHGHHHIJJIJJIIIJGIHHJJJJFGIJJJJJIHGJJJJJIIJJIIIIIJJJGH=CBBCCDCEDECDC;CCDDDDDDDDCDDEDECDDDDDDD#
@67G
CCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGTGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGN
+
@@@DDDDBD?DFD@8)2<<F?DFB?CB<BGI;DFBG?F;F9@@@AGDCA;:??@D@D@>;ACCC5>?;?@>>:588@CC@398><BBBBCCA????BC<<#
@67H
GGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
<;?DDADDDDD2<CE7E@CAED4?EEC<C?DDBBDDEEEEEDEDEADDCDC=AACAA7A@DDDDCDDD??AA@???>>AA>AAA?????;599:>A:9(
@67I
CTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCN
+
@@@FFFFFGHHHHJJIJJJGGIEGHJIJIJJIJJJJJIIIIIJJIIIGIIJIHIGIJIJIGIGIJIJJJJIJFHHHHHEFFACEEECDDDCDDCCDDDCC#
@67J
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCC
+
@@@?BDBBDD;FAGGIIIGG:?ACB@FHE@DH?@:6@?FEFHI==@D9CBEAACH>CBDDECCCCCCCA@C5?5>A@@CA(:5>>:@ACCACCAC
@67K
CTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTN
+
@@@DDFFFHHHHHJJGGEHGJJJJIIIIIIJGIJJJIIIJA?DFGGBDGHIJJJGFHFGHIJJJJIHGGAGIIEHEHFCDFDFEFECEECDCC>CCDDCD#
@67L
GCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
;<@?D=BBFCAD<CC<:@@3<?<F:?<?*:C?GGI<?8DGB@<6966BBF@=;=FF:)7@;?7=AEFD>28;6>@(;;;;AA;;;>@:9::,55@BA3:
@67M
TGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTN
+
CCCFFFFFHGHHGGJIJJJJJJJJJJJJJJJJJIJJJJJJJFHGIJJIJJIJIIJIJGHIHHHHHFFFFEEEEDDBDDDEEDEDDDDDDDDDDDDDDDDE#
@67N
CTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGN
+
@@CF@DFFF?HDHDGGFDHGGCEIHEGHAD<FHGHGDB@GGIIIIIIGGIIEIEECECEE?BAAE@@CDFDCC@CC3:?CCCC@C@A@CCCACBC4:CAB#
@67O
GTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCN
+
CCCFFFFFHHHHHJJJJJJJJJIHIJJHJJJJJJJJJDEHHIHHHHHHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDEEEEDCCDCBCD#
@67P
TTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
CCCFDFFFFHHHHJFJJIJJJGIFBHGGIEHGGGIJJJJIIGIGHIJIIIIHCHIG=FGEIJJCDGGIHH?EHFFFFDECECDEFDDDCDDD;@DDCC
@67Q
TCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGN
+
@CCFFFFFHGBHHEHGIIJJIIJJJJHHGIFIIJJJJIGGIHIJJIGGEHGIFF=CBFFHIGIIIDEGIJJIHH=?EACEDDDCD5@CCDDDDBBDCDDD#
@67R
CTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTATC
+
CCCFFFFFHHHHGIJJJJJJJJJJJIJJJJIJJJJJJJJIJIJJIJJFHJIJJJIJJJIJIJJIJJJJEHHHHHFFF?CFFEEDDEDDDDDDDDDDDFD
@67S
TGAAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCGGCTGTCCATAGCTGN
+
?@@DD?BDHD3ACGHCGDC@<FFEB9AFHIHE@?F9B?@GFBFGHCCHICH==A>6?7;?C@@CCCCCC;5=>CCCCCC@>CCC>(28(58@@CACC>CC#
@67T
CCCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTN
+
C@CFFFFFHDHHHIIIJGFHHJIIEGHIIIIIGIEFGHIJJJJIIIIJGIJJGJGIIIIHGJJEGIIGGG>ECEHECEHHHHBEEDEFCECEEEEDCDD?#
@67U
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
@@@D??,A:BFBDEFFFE68EAFACFFFIIFI@AFII>B>):?BDEFF7B@EC9@@FE?-.=A?77?@@B==>?=>;@;5;,88AAABB?><4>:@@ABB#
@67V
CTGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGN
+
@@CFBDFFGHHHHJJJJJJJJJJJJJJJDHIJJJJJJJJJJJJJJJJJHHHFFDDEEEDDEDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDD#
@67W
GTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTN
+
@@@FFDEDDDFHHEGIGBHIGIGGHIGFGEGHHFDFAEHGGGGGIIIIIIGGGCE@AGHIGIIIGFFHHFFFDDCECCCDDDDDCCACEDCCDD:ADDDC#
@67X
TGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTN
+
CCCFFFFFHHHFHIJJJJJJJHJIIJIJJJIJIBGHHJJJJJ?FIIJJJIIJIIJJJJJJJJJJJHHHFFFFFFFEEEEEEEDDDDDDDDDEDCDEDDDD#
@67Y
GGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGTTTTGATTTTCAAGCACTGCCACTCTGTTTTCTAAACATTTCACATATTCTTTN
+
CCCFFFFFHHHCFIJJJJJHIJJJJJJJJJJJJIJJJJJJIJHIIJJIJJJJIJJJJJJJJJJJJIIJJJIIJIIJJJHHHHHHHFFFFFFFEEEECEEE#
@67Z
AGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTN
+
CCCFFFFFGDDFHIIGJIFIGIEGGIJGIIJIIGIIHIIGIHGIIFEGIIIIIIIIIIJIIJGGBEHEHJEGHJGGHGIJGGIGIICEFHFHFFFFFDFE#
@680
CAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTN
+
@<<DDBDDDFFGFEAGFF?DGIIIIIEIIIIGGHHGIGI?AAAEECD>BEFCEC6=ACBCCCCCC@AACACBCCCCCCC@CACCCC@BB@@:@ACCCCCC#
@681
CCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTT
+
CCCFDFFFGGHHHHIJIIIJJIIJEHHIJJHGIJGGHIJJJIIIHIIIFIGIJJJIJJHGIJJJGIIJJIIGIIGIJJIJGHIHHGFH?@DFFFFEEEE
@682
TGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGAATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGG
+
=??B;DA+2A::?BC<CEE@:FB:<FAFCD*:9E@DDD)))?9:DEA6/7B@=C<@)/8.==;;=A7=.=.7=?3;.7>;2(.5;>>:(5;(,5,:
@683
CTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTCCATGATGTCAACATACTCCTTCAC
+
@@@DB;BDDA3+ABFD>AFHCBF44FDHHBEF9F@<F1::DEFEB>)?DE6BEFDB88B)87@FEFFDEFFF7?A@B;;7@BBA;>ABBBB5>5>@AAA
@684
CCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATA
+
CCCFFFDFFFHGHJJJJJJJJIJJJJJIGIJIJJJGIIIJJJIJGIIGJJJJIJJJJIJJJJJJJJJIJJIIGHHHGHFFFFFFEDDEEEDDEDDDDD
@685
GTGCTTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATN
+
?1:BDDBAHFHFDHIIIGH>EHDEGGIGHGIEHIG?GHGIIFDCC@DGIIF@F@FHIIIBFBEHIIGGGCHIGHGGIGGGFEHEHGACFDFCEECCACAC#
@686
GGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATN
+
????B8BDDBDD:,<<CDAFIIC?C@?4CFEIII<1?EECECDBDBDDDCC/9D</8<==B8B;)8ACCEDD)==3==CAD;@DD6>A..;;5(-;5>A>#
@687
CCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATN
+
@@CFFBADDAHHFEGGGEIDFHIGHHGGHIJJGGDGGGGHGHIJIGGHHGGECGHDGGIBHGHIEIGC=FFGGHGGIGECDHEHEEEEFFCFDC;>6>>C#
@688
CTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTN
+
CCCFFFFFHHHGGIJHGHIJJJIFIJJJIIJJIICHIIEBBFAD@GGJGICGHEHFFDDCEEACDDDCDCCDCDDDBCDDDDDCDDBDCCDDCCCCDDD.#
@689
TTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGATTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHHHFFFFFFFEEEEEDEFD#
@68A
CTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTN
+
@@@==??DBBCFHIHB<CFHIIB>HHIGGGIBEB?CGB<DHHG>>FGEGHI>DEHFB:BDHGFFGH3=FFFA>=FHIEDH@DEEE>C?CDEDCCDCC>>A#
@68B
GCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTN
+
???AD;B?DB<?D:;3ACFDEFA0?D;:BBD?@BDE@6@DCEEE1@;-/?A@A(.6(66>;;8>'5>ADA?=9>?A34448<7><A3<<A>A9A>8A><<#
@68C
GTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTN
+
CCCFFFFFHHHHHJJJJJJJJJJHIJJJJJJJJJJJIJJJJJIIJJIJJHIJJJJJIJJJJJJIIJJHHHFFFFFEEEEEEEDDDBDDDDCDDDCDDDDD#
@68D
GGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTN
+
?;8A;DD;FFFADF;:FFGAFBFFE@@FGF09?GFF*?BFFEE;CFB=9;5=;7A?>>@BCCC@C3(;??BBBB@@:3@A?08A>?292<??<A?BA:@>#
@68E
ACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGT
+
?@<DBDEDGHGGHJIIIHIIJEGGHGIJJJIGFJIHC=FGHIHHBF?FGGHGBCFHGHICEEHGEEHDGCGHE;C>?AEH@B@DFFCCCCC>;CCC;
@68F
GGGGTCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCN
+
@@@D=A:A:CFDAGA>AFB@@FH<EAEFFECD>@GIIIEEICAF@B8B;;@>D@ECEFEEEFEABB>?>@A@@;@5;?8,8<5@>BB:AB>5?7>>ABBB#
@68G
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
?<;?D;=AD??D4::CEBG@F<AC3CF12AFF@9:C?9C?@BFBDF>GFFE2DFFIEFD:<CFC;5.;6=E>)=ADD>@DD:@BCC>65=???BB?B?9&#
@68H
GTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGN
+
@@CFFBDDFHHFHJIJGHIIIJJJIIJJJJIJJJEHGIFJGJIGIIJIIJIGGFHGIIJIGIJGCGHHBCCCDFFCDCEACDDBDDDDCDDBBD5?CCDD#
@68I
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
@@@FBDEDDFHAHIJJGIIEHFFHHEDHHJIIDFHG:DGIEEHFGHI@FHI;AHEHHEFEFFEEAEA@CCDDDDDDD@CCAC@CDCDDDCDD>@CCDDCC#
@68J
CCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACN
+
@@@FFFFDHDAFHIIIIJJFHHIIEGHGG?EB?DDGHIGEDFFGHJJJGHIGHIIHH>BEDDDCCCCCEDCCADCCDDEDDC@CCCA??CDC@AACDD>B#
@68K
GTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTN
+
@@@DFFDBDBDB?FBFGBFBGIIIIIC@FHGIGHIGID@GEHB?@FHG<FGGHBHIIIGADH@<BBEFB?D>CC>=;;?BBBBBB?C@ACCDECCA<<BB#
@68L
GCCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGT
+
??@F=DDFHGDFHHEGGEHHAFGGFHHHHIIIIIGGHHHEBHIGIIIBHFFGADGGGHHIGIIIIGIII@HGEHGHEHHIIIA@EHFHHHACDFDFFCE
@68M
CGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGN
+
@@CFFFADDHGHGFJHGIIJJJJJJIJJJIJJJJGGGIIGJJJIHIIJJIJJJJIHGHHGIJJIJHFFHHDFDDDDDDD;ACC@BCDDDCDDDCACCDCB#
@68N
GTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTN
+
@@BFFFFFGHHHHIIFGHIIJJHIIIIIJJFDBDDDDDDDD9BBDDD:@?CDEDEDDDDD7@BDDDBDD2<@AC@CDDDACDEDDDBB@BDDDDDDDDDD#
@68O
CTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATC
+
@@@DD8DD?CFHHBHIG>CGH@@EHD?EEFA?AGGCHHGEAHG:BDFHIE988BFH>FACFDFFH>@.77@;AC7A:B@CBEC;=AA@@ACAACCCCC:
@68P
GAACAGATTCCTCCACCATCATAATGGCTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJIIGIJIGGCHEGEGGEGHIGIJIGFIJBCGEG@FEFHIGGH@CEFHCEBEFF>CCCCEEDDDDDA?@C#
@68Q
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
BCCFFFFFHHHFFIIIIIJJJJJJJJJJJJJJJJJJJJJJJHHIJJJJJJJJJJIJJJJJJJJJJJIJJIJ=EFDDFFFEEEEEDEEEDDDDCDDDDDDD#
@68R
ATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACAT
+
@@<DDFDEFHHHBHHE@BGGHIIEHIIIIIGIGHIGIIGIIICGHGGEHDFGEGHGG?FFGEIIIGGFGHEGGIIIIGIEIIIHHGFFFDE@CCECCC
@68S
GGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGC
+
CCCFFFFDHGFDFHFGHGHGHIJGGGIJJJJJIJIBEHGGIJJIJJGHJIJEGGIIIIGGBDFEDEDDDDDBBDDCCD?CCCCDECDCD>CD<@BDBBB
@68T
CTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTN
+
==?;7=ADFHDD0CA?A?:C@AGHA<49CBD??*:BF3?BDB;?BD@GI??3=6B=F@A...=DHH3774=,99>>-5@>-55,(:ACB55?::@0?<24#
@68U
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTN
+
CCCFFFFFHHGHHJJJJJJIJJGGIJJJJJJGIJIJIIJJIIHIIHIIIJJJJJIJHIJJIIJJJJJJJJJGGHHGHFFFFDDDDACDFDEDDDDDDDDD#
@68V
CTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
?:?=D?DDBF<ADAFG?@GCHHHGH@HGEHIIGGGIEG@>CA8:@DEHIIIGEEAFGC9FGIAEEEG3=CH@;;BCBCCCC>AA=CA><=B<2?:@AA
@68W
GCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCN
+
@CCFFFFFHGHHHJIIGIGJJJJJJJJJJJJJJJJIIIIJJJJHIIJIGHIIIHHHHFFFFFCEE>B>@BCDDDDCDD@@CBDDBDDCDDDDDDDDDCCD#
@68X
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGN
+
CCCFFFFFHHHFHJJJIIFGGIGIIHIIGIIIJJJJJJJJJJJIIJIJJIJJJIIHEHIJJJAHHGGDEEHHGEFFFFDDEDDDDDB@DDD9A>CDDDDD#
@68Y
GTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGN
+
@@@DDDFFDHDDBGBHEFHEGIIFEGHFHJJJHEIJEIJCGIDGIBBGIIJGHJJFCHEFHFFFF5?BDCCCDCCCCDDD?CDBBB>@2<>BBDBBCDDD#
@68Z
CCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCN
+
CCCFFFFFHHHHHJJIJJJIJJIJJJJJJJGIJJIJJJJJJJJJJJGHHIIHHFFFFFEEEEDEDCDDDCCDDDDDDDDDBBDDDCDDDDDCDDD<<B@C#
@690
CAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTG
+
@@@DDD<DHHHD>4<AC?FHGHC>FEHH7FHH4DFBCGAHI<2@?FGAEG=B=@=75@D;=A;77?;B1@B@ACCC;@BC::5<?BC<?:34<AC??B
@691
GGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTN
+
CC@FDFFFHHHHHJJJIIFHIIIJJJJJFHJIJJJJJJJJJFIJJJJIIIJJJJJJJJJJJIIHHFHHFFFFFEEEEEEEDDDDDDDDDDDDCDDDDEEE#
@692
GGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTN
+
CCCFFFFFHHHHHJJJJJJJJJJGIIJJJJJJJJJJJJIJJJJJJJJJJJJJJHIJJJJJJJJJJJJIJJJJJJHHHHHHFFF@BDDDDDDDDEEDDDEE#
@693
GTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTA
+
C@CFFFFFHHHHGJJJIJJJJIIJJJJIIEHIJJIIJIJIJJJJJJJJIJJJIIHGGIJHGGIIJHFFFDEECDEDDD@BDDDDDDDDDCD?CCCDDDD
@694
CTCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTN
+
@@@D??DDFCADDB?AFGCGDHICFEEEAEEAEDHEGGEHGGEGEHIBFBAG5;=?AHE>6?DCCC@>C>CC@>;;8=?>:::9>>34>@@BBBBCCCC@#
@695
CAGGGCGGCACTAGGTTTCATGCTCATATCCGGTCCCGGCAATGCAGATGCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCN
+
@?@=BBDDFHFHHIJGHIJIIJJIJJGIGDBBGIIIIGI<?EFFDECCCEDDDDDCCBD<BBC@D>ABDB@DDA>:?<8?ACCDBCCCDCABCDCAC@CD#
@696
CGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTA
+
BC@DDFFFFGHHHJJJJJJIJJJIJJJIFGIIGIJJJJIIJJJJJGGJJJJJJIEIIJJJJJIJJIJCHJBFGCHIIGIE?EHFFDDCDCD@CC?BDD
@697
GTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGN
+
B@@FDFFFHHHHHIJJGIIIJJJIJJJIJJJJJJIJJJJJJJJJJJJJJIJIJIJCFFGHGCGHIJIJGIIIHHHHHCHFFFFFFFEEEDDDDDDDDDDD#
@698
GGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGT
+
@<@DDDDADD>DFGHEDH?FEGHBGHIIIIIIICEEIIIIGCCFIGHEGFFHIIIGGGGHAGH=AGHAGGEEHF?EFBBDDD@C>ABCB?@BBBBB095
@699
CAGGGGCTCGACTGCATCAATGCTGGGCGCAGGACACAGCAGCTCCACAGCCCCCGGCGGGCACAAGGGCCCATAGCGACAGGCAGGCTGGCCGTCAGC
+
????;DD)<0@C1<<39?BF>GCD?F=GA?6@FF@F==(==DC===..7A=;583,',3;@@<8?<<(8?BB8(+::9005>BB8<<08?@(8005<.4
@69A
CTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTN
+
@CCDFFDDHHHHHJGIIJGGEEHGEIGIIIJJGIIIGIJIIJ9@FHIJGJEHHFFFDDECCDDDDDDDBDB>BBC>CCD8<?CCCCDDBDD@BBBD@BDD#
@69B
CAGGCATGGAGGATGGGTGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGAAGTCAGAAGGGTACTTGTACATGG
+
=??;12ADDBD7A?EB+CF8?ED<DI@;DBA88==8)88888@ACD37)5ADDD@;(((;(-;??>:?5>>AAA9(5:344>>A<929:A>A4>>>>:3
@69C
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@CCFDD?DDHFHDGBDHEHGIDHGHGHIIIHHGGII<GGIGHIEGIHHHIGCHI>FHIIGEHG@EHF=@AAD>@;ABBA?BBBBBCCCBCACCCCCCCCC#
@69D
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCN
+
@@@DFFDFFFGHDHGGEIIGIGAEGEH@F@GBFHIEGGIEHIGGIJIEGGGG;CFHJIFEEHHECDEEHHHD>?DCDDEDDDDDCCDAC:A>5>:ACCCC#
@69E
GGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGN
+
CCCFFFFFHHHHHJJJJIJJJJJIJJJIJJJHHIJJJJJJJIJJJJJJJJJJJIJJJJIHHHFDDDDDDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@69F
GCCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTN
+
@@@FFFFDHFFHHIDBGFHIEEIEGIGIIFFGHHIIIDGGDHIGHGGIGGGIEGEDEFHFFCFFDEEEEDEDCCDCDCDDDDDDDC<?B@A@@:ACCDDD#
@69G
AACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACN
+
@?@DDFADFHFHBHAEHGAHHIHGIIBEGG9CBFGGDBF@EHBGG9DHG8DGG-=CGDHGGCEHACBCDFF<AACA??BBCDCBDD=;8ACCC@?CD:AC#
@69H
GGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGN
+
@@@DDFFFHGGDHIICFEHGIIGIIIE3<CHI:EHCFHIFGGGEC@@FGGAHI9DFHIIIIIFEA>BBADCACDDC@CCCDCC@BDCDDBDB>CDDDDDD#
@69I
CTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCAGGTCTCGGTGCACAAAGTGCTGGGAGGCC
+
@@CFFFFFHHFHHIJJBHIGIJJJJJJJJJJJGIJJJHGIJIJGIJIGIJGGIJJJIIJIHHHEHFFFFDDCA@CDD=@BCDDDDCCCDEDDDDDDDD
@69J
CTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATATGGACAGAGTAACTACAGTTATCCCCAGGGACCTGGGAGCT
+
:?@DDDB;?DF>8CF>EAG@CHE,,A?@3+A1:CD02?88/(-((--(6@;)=3?;)=;@33.7,....-((;35((,;>5:AB?@1&888?9288(0<
@69K
GTTTTTCTTGGCAGAAATCTTTGTCTGCATGTGGTTCCTTCTCTTCTTTCCTCAGACCACAAGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTN
+
?@@DAD?A==DAFACGIDFEHFB3AA9?<CAC<C?E?DCF@GIB@<DFFBB@DF;?@FEDBGCBC=@FGGEIIG@G;C65=D>?CC;6@BBB;=<:5:@@#
@69L
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@@@DDFFFGHHHFIIDHIFEHGHGHHG?FHIIDFCFFHIGIJJEIJIGGGGD@@DDAGHIGHHHHHGFD>>BB@CCCDCCCDCCA:>ACCDDDDAD?A
@69M
CTTTTTCTTTTAGCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTN
+
BCBFFFFFGHHGHJJJIJIJIIJIJIJIJIJJJJHGIJJIIJIIJJJJJIJHIJJJJJJJJJJJIJJIJIIIIHHHHGHGFFFFFEEEDEECEDCDCCD@#
@69N
GTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCTGCATCTTCCTCCTCTTCCAAGGCCATGAGTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTN
+
CCCFFFFFHHHHHJJJJIJIJJJJJJJJJJHIJJJJIJJJJJJJJJJJJJJJJJJHHHHHFFFFEECCDDDDDDDDDDDDDDCDDDDDDBDD@CDDDCDD#
@69O
GTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGG
+
CCCFFFFFGHHHHJJJJJJJIHIJJJJJJJJJJIJJJJJJJJJJJJIJJJJIGIJJJJJJHIIJJGIIIIHHHHFFEFFEEEECEDDDDDDDDDD@CCD
@69P
CTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIHHHHHHCFFFFFFFE#
@69Q
ATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCN
+
@B@FFFFFHGHHHJJGJJJJIJIJJJJJJJJIJIJJJJIIIJJIJJJJJJHHHIJJJIJHIJJIJJJJIIJJJJJJJJJJJHHHHHFHFCFFCCEEEEDD#
@69R
CTTTTCAAACATACAGCCTTCTGTTCCGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCGAGGCACTTCTGAGTCATATGC
+
:??A1DD8A=?CD<2A3AA4CC+33<,)1))?D?CB?D>C*0B8?;;(/=3=BCD@C>78=@CCE=CC)?CC=?>;(',,88<9(:4((+4++((44(+
@69S
GCCTTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATN
+
C@CFFFFFGHGFFGFHHHHIJIJJJGHHHJEGGBHHGIGHFG@FHGHEEFHEGIJGGGIIIJIGHGEIDEDHI;AEEE?D>C>@C>A9AC@@A::AA>@C#
@69T
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATA
+
CCCFFFFFHHHHHIJJJGIIIJJIJJJJJJJJJJJIJJJIIJJIHIJJJIJJJJJFHIIIJIJJIGIGIFHHHHHHEFFFFFEEEE
@69U
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHJJJJJIJJJJJJ@FHGIIJJJJJJJJJJIIJIJJJJJJJJIJHHFFFFFEEEDEEDDDDDDDDDEEEEDDDDDDCDDDDDDDD?<
@69V
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJADDCEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@69W
AGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJIIJJJJJJJJIIIJJJIIJFHIJJJJJJJHH?EFFFFFFEEEEEEDCCDDDDDDDDDEDDDDDDDEE
@69X
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGN
+
CC@DDDDEHGHHBGGHIJJEICHEGGHJICEGHHGHIEHI8BFGIFCGDHHIIGIG;CEHGI:=ADBCEFDEA@CACDDDDDDDDCDDD>CA@DED@A>A#
@69Y
CTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTN
+
@@CDDFFFHAFB?GBFHHGEEBFEHIGGFIGEDA?FGIIIIIEHII?FHGIIIEGGGIIIIIIIIIIIIIIGHGGHGHDHH?CDFDFFFFACEECCEEDD#
@69Z
TTTCTATAGTAATCATTTTTATAGATGTCTCTGGCGAGTCCAAAGTCTCCAATCTTCACTATCCGTGGACTGGTATAGTCTTTCACGGAAACAAGGCAATN
+
@@?DDDDAFC?D?EEF@D>?CBFH@FHEG@@HEGHGGG@;G@DBBFG9BFGDFHIGGEICFHCEGFGHIEHCE=ABEC;;@DECCCCBBBBCCBCBBBBC#
@6A0
CGGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATG
+
@@@DFDEFGHHGFIJFIJJJJJJIJJJJJJIIJJJJJIJIJJJJJIJGGHJJIJJIJIJIJJJJJGIIIJCHIGIIJH=AAEFFFDEFDEEEEDDDDDD
@6A1
CCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGACCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGN
+
:?8:=2B:D??<D;CC;@)@@@@:D9?D7)::?)*000*09(--';8..7=.)=(.=,'9,3,5;;55:=(,8(,:54482+>A>A>((8;2>?>(+(::#
@6A2
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGGGCAGTGGN
+
@<@DFFFFGBHHHIIFI=GEGBH;FF>CGGEGEIGHEH@D<BDHADGFIBGEGGHDCFCAGGGBHCEAE;CDFFEDC>@;ABB8=@CCCACC09<5<?CC#
@6A3
CTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCAC
+
CCCFFFFFHHHGHJIJJJJJJJJJJJJGJJIJJIJJJJJJJJJJJJIIJJJJJJHIHIJJJIJDFFEEEEEDEDDDDDDDDDDDDDDDCDDDDDCCDD
@6A4
GTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATN
+
??<DDD4ADDD?D:C:B:CE<<CAFEFDE@?F<CEE@EC?D;:B9?:DDCB;?D9DDEIE(8B9.;;@;C@CDDDD>7?A>;?.63>>A??5;=>>>5>>#
@6A5
GGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJHHHHHHHFFFFFD>C#
@6A6
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGN
+
C@@FFFFFFHHGHGIG@GCGHIJJIHEGGGIJIGIGGGHCIIGIBFHCFHIBGHHF@GH?B>CECDCACCC;59?AC:>C>A>?>C@CDDDD3>ACCACD#
@6A7
CTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCN
+
@@@FDDDFFHGAHGEHIIIJIJJIGDHGHGGIGGIIIIGGIJFGIIJJCEHGIJIGGGEIJJIGCGHHHHFDDFECEC@@CDD@CADDDC?5>>CCCCCC#
@6A8
ATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGN
+
CC@FFFFFFHHHHJGFHGIJIJJJJJJJJJJJDHHJHHGI?DGIHHIIIJJ@FHIIHJFHHHHHFFFFEEEDD>@BDDDDDDDD@CDDDDDDDDDDDDDC#
@6A9
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
BB:BDFFDHHHHHJJJJJJJJJEHIJJJJJJJJJJJJIJJJJJJJJJJJJJJHIJJJJJJJJJJJIJJJJJJJJHGHHHHFF@BCDDDDCDDEEDDDEED#
@6AA
AGGAGATTGCCTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCAC
+
@CCDDFFFHHHHHIIIHJIHGIGCFHJFJIIFHGJJJJJIHGGIJIIGJJIJGGIIIJJJJHHHHHFFFFFFEEDEECCDDBDDDDDDDDDCDDDD
@6AB
CTCATACGTGGGAGGGGGCTTGCTCTTCATGGCCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGG
+
=:;?;DB:2:?1:<E))8:@D?9D4B<*99*9(.-;';;5=.,;A@;.(;>AAAA>AAAAA>>A<>5>>A>ADBB>>:>AAA298<<AAA>9A>9>?<.
@6AC
CAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGN
+
@@<DFFFFHFFDDFHEHAEIEGIGIGGGIGGGEFHIIGHGGADBFDHGGEGHECCDHHIGGIGGIECHFEEHFFEDCB?AB?BDCBB=B><??A@BDBDD#
@6AD
GGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGGGGTGGGAAGGGGATGTTN
+
@@@D?DADBBFDFG@<GHGGGBG:FH<>?9@@BDFB*?8DB8BC@HAFEGG7@ADC=ADB33?>>A5>;A>;:;:A@C(:@C(2<)55<<CBBBB3<B4:#
@6AE
CACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTN
+
@@??DBDBACFFHBEHHHG=@GHD=ECFFHGD?GHHDGG@?FBH@5599>CC@C(+3:@3>C>:CB4>CB8?>@1<<C@CDCCCCCCAA@CCECCCCBCB#
@6AF
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
CCCFFFFFHHHHHJJJJJJJIIJJIIJIJJJIIJJJJJHHIJJJJGIIIIJIJIJJJJJJJJIJJIHEFFFEEEEEEEDDDCDDDDDDDDDDCDBDDDDD#
@6AG
CATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGN
+
@@@FFFEDHHHHHIGFGGGIEIGGGHHHGGG?<DFGGEHIIJFIJJJ?FH@C@EHGIJJJIJIIGG:CGGHEEHHFF@DDC@>@AAD;BBBDDDDDCACC#
@6AH
CTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGN
+
CCCFFFFFHHHHHJGIJJJIIIIEFEHGHIJDFHGHIIIIIJGGIIJ@FHIGAEHIHHFFFFFEEEDDDDDDB@DDDDDCDDDDDDBDD9>9@DACCDDD#
@6AI
ATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGA
+
CC@FFFFFHGHHHJJJIIJJIFHGGGHIGIJIJGIIJIIJJJHIIIFHIJJJFHIGIIIJJJHGHHGHHFFFFFDEEEEDBDDDDDDDDDD@CDDCDD
@6AJ
CTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACC
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJHIJJJJJJIJJJJJJJJIJIHIJJJJJIJHHHHFFFFFFEEEEEEDDEEEEDDEEDDEEDDDCDBDDD
@6AK
CTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCN
+
@@@DFBDDDB?CFEHBA@HE@@DFHGCDGGIGGGIA?B?D6F8@@=B?B?BA=ABDEC??@==<?ABD<BC@>A>CDBBB>A>>>@DCDC:>?AC<?C@@#
@6AL
AGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCN
+
@@@DDDDAB>FFF:GAGBCHIF3?DEEHI9?8DF8@@4=EAHFDEB??;3=@A?;55:3:@DC(:;>C@ACACC@<<?9?B?<>CACCCCA::>::A@A:#
@6AM
GATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTG
+
=??BBDEDFFDADAFGCEHIIIGEBHHIGGIJIIJJIJ@HGCGHIHIJJJIIIHCHGEHGHIAG@HHDAHEHHHFEFBCDF@CCCA=BD
@6AN
CCTCCTCCAGTTAATAACATCCCATTGCTCATCTGAGAAAATGTGGAGAAACTGCCATCATGAGCTGTGGTTTGTTTGCTGATTTGAGAAACACCTTT
+
??<D?D3B+<<C,,A4<AAE3<CEB+++22+<+*****19)*11**:)0)**09**093?4=4B38)8=)81((6?)))7?3)...((((.-(5>3((
@6AO
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
@@@DDDDDB?FFHHG>DBFHHCG@GHDF9GC@FHA<DFGGHE0?F>7=7)=4@CE;6@;ADF>;66>AC;?;>@@CCC@CC@CBCACCCC:>@:>C>+44#
@6AP
CCCTGCCTTCTCCTTGGGGGTCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATN
+
@@?DDDDEFFFHFFHGJGGEIHIGHIJJGHHHGHCEEIDC?FGEGHEB=@GGIGIGHFHFFFDC>CEECCDCDBD@ABDBDDCCCDDDDCDDDCC@@>AC#
@6AQ
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGTN
+
BC@DDEFFHGHHHJIIEGCHIHIIIJGHHIIJJJJIJIIJJJIIJJJGIIIIJCHIIJJJIJIHIJGJJJHHHFFFFFFEEDEDDCDDDDCDDEDDDDDD#
@6AR
AACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
@@;DDFFFHGFHFJJIHHIJIJIJJJJJJIJIJIIJJIIIHIJIIJFHGIIDHIIGHFHH>DFDCFEEEEDD;CCEEDCDD?@CDCDACDDBC@?CCCD
@6AS
GTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGTAGCTCTCCGACTCTGAGGACN
+
?@?=DBDDF<4<+2<C:CF?CFAHEFE9C?9C><B0C@BFFFIFCB:??/===FBFFFE@A:=3;C(((7;@;;;(;@(((-5;3(5>=6=05:4>4?(2#
@6AT
TGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCN
+
@@@FD?DBHHHHHIEHHG@HFHHHIIIHIIIIIFHGGGGIFHH@F8@ACAGIIIIGFHFEHEDFF7.6@ACCCCCCCC>@:>@CB@9',:::>>>@ACCC#
@6AU
CGTGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGG
+
?@1=BDDDHFHHDHBH@BEEHEHIEIIIIIIICHGBGFHIIIGH@GHHIIGGHHBFGHGIIIIGIEHBH@D;EBHEEACCCC>@C@>9;AACCC<AAAB
@6AV
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATN
+
CCCFFFFFHHHGHJIIIJIJFGHIGCFHEGHHGGIIIJJJJGGIIHIIIJIJJEGGIJJJIHEFHFEBCFDDECDB@@CDDCDD@CDACDCDDDDCDDDC#
@6AW
CGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCN
+
CCCFFDFDHHHHHIJJJJJJJJGHIJJJJJGHIIIJJJJJJJJJJHIIJJHBEFDEEEEDEEDEDDDDDDDDABDDD<BDDDDDDDDDDDDDDEDDDDBB#
@6AX
CCACCCTGTAATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCC
+
CC@FFFFFHHHHHJJJJJIJJJJHHCIIJJIJJJIJJJJIJJJJJJJGIJJJJJJJJJJJJJJJJJHHHHHFFBCDEEDDDDDDDDDDDDDDDCCDDD
@6AY
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
??::ADDAFHAFB@9EGGIIIBHIIC9C@F??GAFFGIIIIIFHGI@FCEHEHAGIIIHHEEEDCCCCCCCCCC@CCCCCCCC9AACC:CAC:ACAAC:3#
@6AZ
GTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGC
+
BB8BDFFFFHHFHIIJJJJJJJIJJJJJJEHJJJJJJJJJJJJHIJJJIHIGHHHHHHHFFFFFFEEDEECDDDDEDDDDDDCCDDDDDDDDDDDCDBD
@6B0
TGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGN
+
@@@DDDBDF?FFDIIFBECGIACA?<FFGEIGHCDBFADGGHIGGGGEGGGGHHGIIIIBGACEEH?CC@DEEBCCCCCCCCCCB(5=@(58?>@AB9??#
@6B1
ATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGN
+
@@@DDDDFHHBBFFHIIGIIGJIJJJIGGJIIIIIEGFGGGIGIJJJJJEIIIJIJIJJJIEIDFGIGIGJIJJJGGHGHHGHFFFFFACCDEEEDDDDC#
@6B2
CAGTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGA
+
=?+=B?;BFFHFFIIHGGGGGGH>HHIGBH>CFHCHGI??FHIH?BGDDCGGFHII=CEHIIHIBHHHFF?BDEB;@>CCCCCBB@5>@@ACBBCBBBC
@6B3
TATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCN
+
BB1BDDFFHFHHGGHJIJJJJJJJIIJJJJIIJJJJJJJJJJJJJJJJJJJJIJHIFHHHHFFEFFCEEDEDDDD;AADDDDDDDDDDDDDDDDDCBDDD#
@6B4
ATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTT
+
@@@DDDDBFHD:@FEHCAFGEHHIEGFE1)?FGHIIFIIFG@@0BGHCH==F=C@FHF=;=@CH=A?A==A7;7;.7?C;ACCAAC(555>C:>=;??8
@6B5
GCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGN
+
CC@FFDEFHGHFHJJIJJIIJGGIJHIIIIJJJJJJDHHGIJJIJHIJJJJJIJJJIJJJJJJJJIJIHIJJIHFFHCHFFFFDDDDDDEDDCEDDDDBD#
@6B6
GGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCN
+
@CCFDDFFHHHHHIJGHIBH@A@AHEEEDDDFE@@CEECD=@;@CCDEDCDDDBB>ACDCCDBBDDACCC8?B@ACCCCDD?CA?CCDDDDDDDDC@CDC#
@6B7
TCCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTN
+
@@@DDDDDFFHHFIFI@FHCG@GHHIIIGGHIIIIIIIIIIIIIIIGIGIIIIIFHHFFHDEEEECCCEDEECCCCCCACCBCCBCCB<ACCCCCCCCCC#
@6B8
GCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGACAGCAGAGCAACTGGN
+
CCCFFFDDHHHHHJIGJGIJJIGIIJGGHIIIHGIJJJJJJJJJJJJJJJIIJIJFFHII@EE:CEHDFFFCDEEEDBBDDDDDDCCC?CDDDDDCDDDD#
@6B9
GTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTN
+
@@BFFEFFHGGHHJIIJJJJIJJJJJJIJJJIGIJJJGIJJJJJJJJJJIJJJGIJGGIIJHHHFHFHHFFFFFFEEEEECEDEFEEDCDDDCDDEDDDD#
@6BA
TTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCT
+
CCCFFFFFHHHHHJJJJIJHJJJJJJJJJJJJJJJJIIJJJDFIIJIJJJJJJJJJJJJJIJIJJJJJJJIIHHHHHGFFFFFFFDEEDEDDDCCDDD
@6BB
TTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGT
+
CCCFFFFFHHHHHIJJIJJ4FIGHIHIJIJIIJIJJJJJJJJJJIIJJJJJJIJJJJJJIJGHJIJJIIIIJJIJJJIIJIIJIJIHHGHHFFFFFEEE
@6BC
GTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTN
+
C@CFFFFFHGHGHIJGGGCBHHHJJJJIIIIEFEBD>DCFDEHIGIIBHHJGFGHGIGHIJJIDGDHFHF>EEEDFFFDE>CCDCCDDDDBDDC@CDCDD#
@6BD
CTCGAACAGAGACCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJGHIJJJJJJJJJJJJJJJJJIIJIIJ;FHEHIJHHHHFFBEDCDDDDDDDDDDDDDDDDDDBDDDDDCDDDB#
@6BE
CTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTN
+
@@CDDFFFGFHGHJJJJIIJJJJJJIJJIDGHIJJIJJJGGIGJJJJJIJJJJIJGIJJJJJIIJJJJIJIIIJJJHHHHFFFFFEEEDECEDEDCDDDD#
@6BF
CTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTN
+
CCCFFFFFHHGHHJJIGIJIJJJJJIJJIJIIJJJJJJJJJIJJJIJGJIJJJJJJJJJJJJIIJJIJJJIJJJJJJJJJJHECHEFFEEFEEECCEEDD#
@6BG
GCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJGJJJJHIJJJJJIJJGIJEGGHIJJIJJJJJJHHHHHHFFDD?CDAB@CDDDDDDDDDDD#
@6BH
GCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCN
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJGHIJIJJJJJJJJJJJJJJJHHHFFFFFEDEDDDDDD@CDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6BI
GGCCTCAAGCAGCGTGGTTCCACTGGCATTGCCATCCTTACGGGTGACTTTCCATCCCTTGAACCAAGGCATGTTAGCACTTGGCTCCAGCATGTTGTC
+
?@@DFFFFHHHDGGEHHIGIJIIIJJJGGICCHIJGGIGHJEDGDG?FGIIJJGGHIIIGAHEHHHFEDCECECEECCDCCCDACCCDCDCDDDDECDC
@6BJ
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJIJJJJJJJJJJJJFFIJJJJJJJJJJJJJIGJJJJJJJIHHHHFFFFDD>BD?BD=BDDDDDEDDDDCCD>@#
@6BK
GTCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJIIJJJJJJIIJIJJJIIIJJJJJJJJJJJJJIHHHHFFFFEEDEEEDDD>BDBDDDDCDBDDDDDDDDDDDD#
@6BL
GGGTGGCAAGACCCCAAAGCTCATCTGTATGACCCTGTACTTCTATTTGGAAGCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACN
+
@@CDDFFFHHGHHJJJJJIJJJJIIIIGIIIIJJJJJIIIIGHIIIJIJJIJJJJIIIIIJIJJIJIJJJIIHHHFFFFFFEEFEEEDBBCCDCCDDDDD#
@6BM
GCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGN
+
@@@DDDD;?CDFHEGEGEGHIIEEHIGHG@EFHGIIIIIGIEHDGIGIGGFHDFGDFDEGGHHEFGHEGHGHIEAHFEEEBD?CDCDC@ACCB@-9:@@C#
@6BN
CTGCCGCTGAGGGTGAAAGCATCCAGTTAGCATATACACTATCATTTGGATATCTTGGAAACCCAGTGTTAGTGCCATCAGCTCTCGTGAGTGGTACAGGN
+
@@@DDD?@F8<DA<AA<E9C??:???:?C9DC<B?FBDHI;BG<BGIB??FCC<=BFHICC@=;5@CEEA;7.7?BE?)7.>;>CC@B=35,,<@:@C><#
@6BO
CCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCN
+
@@@FFFDDDFHHDIGIGHHEGIGEGHIIIIIIJJIJGHIJGHIGGHIGIGAHGEGGHHHHIEDGIIIIGGGIGDGGGHGICIHEEEHHGGHEFFFF@CEE#
@6BP
GGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGN
+
CCCFFFFFHHHHHIJJJJJJJHHJIJJJJJJJJJJFGIJJJJJJJJJJJJJJJJJJJHHIJJJHHHEHFFFFFFEEEEEED=CDDCDDD8ABDCDDDDDD#
@6BQ
GTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACN
+
CCCFFFFFHGHGDIJIHHIJJJJJJJJIIJIIJJJJJJJJJGJIJJJJJIJHIEHHHHHFFFFFEDDDDDDDDDDDDDDDDDDDD<@DDDDDDDD@DDBD#
@6BR
CTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGAC
+
<@@DDFFDHHDHHGIGIFEEHIEIIGIBE@DGBH>EEEEIHGIEGGIJBGI@<DDEDEECCDDDCDCCCDD:CCACD>CDD@98?<@C
@6BS
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
BB@FDFFFCFHHHJGJGIJJJJJJIJJJJJJJJIIJJJJGIGEIJIGGGIBHGGHGHFHIIJFGFGGHGGHEFFFFFEDEEEDDDBDD?DD?BDBBD0<
@6BT
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCN
+
CCCFFDEFHHHHHJIJIJJFIIJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJIJJIIJJJJJJJCGHIEHHF;@ADCEEDDDD=ACDDDDDDDDDDDBD#
@6BU
CCCGACGGCACTGGCGGGGCACTCTGGGGCACTGCACCCCCAGCCAACCCCCCATCAATGAATGGGTAATTGACCAGCACCAGTTTGTTGAAATTGAACTN
+
@@@DDDDDHHHFFIIEH;B>/;6;>>ACB6=8(5>>:?BBB1(2?0<8<BB07&(3:>:>(::@C?+4?4>(+:>(+2(8?22+:A@?C1(:@>C3:@:4#
@6BV
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCN
+
C@CFFDDFGHHFHJIJJIJJJJIIJJJJJJJGJJFGHJJJJJJJJJHIJJJJIJJGHGHGHHFFFFD;CEDEDDDDDDDDDDEDDBDDDDDDDEDDDDDC#
@6BW
CTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGN
+
CCCFFFFFHHHHHJJIJJJJIIJJJJJJJJJJJJJJJJHFEDDDDDDDDDDDEDFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6BX
GTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCN
+
@B@FFFFFHHHHHIIIIJJIJGIIIJJJJJIIIIJJJJJJIIJJIHIJIIGIIGGIJJJJJJGHJIJIIJJJJHHHGFFFFCFEEEEEECCDACDDCDDD#
@6BY
CATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCN
+
@@CFFDFFBHDHHIEIIIIIGIGCHEHIIDGGIGH@F9BFCFGEGHHGGIBGE;CEH@DGB:7?CFCF@CB?B8>;>@BCAC?C@ACCCC?CC@C>CCA@#
@6BZ
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCN
+
CCCFFFFFHHHGHIJJJJJJJJJGHIJJJJIJJJJJJIJJJJIIIIHIJJJJJJIJJJJHHHFFFFFFECDD3>BDDDDDCCDDDDDDDDDDDDDDDCCD#
@6C0
CCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGA
+
CC@DDFEFGFHDHIIIIGGG@HI?FEHGHGGHGICGIIFHEHEGFIIICGDEGCEEFDCCAC@CB;ACCDCCC>C@@BCBCECECCCBBB@>@95@<@C
@6C1
ATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTN
+
@@@BDFEFHGGHAHIIIIGGDDFE@EDHEHHGGGD?=B??F?FB4?FCH>?@?BAGCHHGDGIEGG=;C4CC?EHF<BD?EEEA<??@B@@BB<25>:4@#
@6C2
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCN
+
CCCFFFFFHHHHHJJJHHIJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJHFDDDDDDDDDDDDEDDDDDDBDDDDDDDDDDCDDDCD4>B@CCCCD#
@6C3
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CCCFFFFFHHHHHJJJJJIJHIJJJJJJJJJJJJJJJJIJJJHIJJJJJHIIJJJIJJJJJJJJJJHGIJGHHF;BCDCEEDDDD8ACDDDDCDDDDDDD#
@6C4
CAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGN
+
@@@DFFFFHHGGHGHJE@HHGIIJIJIJJIJJJIJJGBEGG6BB8ACCCAC>ACB@CDDDDDD:@???B@@ADBCCDDC@CACCAACDDEDDCCDD<BDC#
@6C5
CTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCG
+
@@@DBDD;DFD?DEBFBECBHGEHHIIDFB@DBBDG9F@CDECD5;6/4?=ABE;=5;;;@>CCC;A>CCCCCBBB>>5<<58?8>A@ACB
@6C6
GGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGAAGTGCAGGGGATGN
+
@@<DDDDDDFHGGJJECEGIJJIIJGHGICBHGII1?GDD@GCDHHH9<FI4@H=EHFF;@DD=C=ACDDDDCC5<@D8@5?CCDDBB@>ADCCDBB>BB#
@6C7
GGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTN
+
CCCFFFFFHHHHFHIGIJFHIIJJIJJJIJJJIDGIFGIJJIJJJJJJJIJHIJJJJJJJJHHHHFFFFDDEEDDDDBDEEDDDDDDDDDB@BCCDDCD:#
@6C8
CTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGN
+
?<?B=AABA<CA::<AE3:33C732+<*?CED99*?D9:CE@B008B@B?<8??DB8B3)88AD;ADE7=;@D>=?;@D;3?;7;>9;?AA:5;A>35:=#
@6C9
TGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGC
+
@@<DBDFB?FBFHIEDAEHCH@E>CC??AF?EEDEC:?C:DDBBD9DHHHGGHBB8B>B:/:9??B??CE==????A<<C@C::@:A3:3
@6CA
TGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAG
+
@@@FDEFFHGHFHJJIJJJJJEIGIJIIJJIGIJJJJJJJJJJJJJJIJIJJHIJJJIIJJJJJJJIJJJGHHHFFDDEDDDDDDDDDDBCEDDDDDD
@6CB
TGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJIJHIIJJJJJJJJJIJJIIJIJJJJJJJJJJIIJJHHHHGHFFFFFFEE#
@6CC
GCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJGHJJJJIIJJJJIJJJJJHHJ@FI@DHIHHHHHHFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDD#
@6CD
GTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGN
+
@B@FDDFFHHHFHJIJJIFIEFHGGIIIHIHIJJIIJJHIHIGJIJIGGIHIIIIJGIHIJJJJJIJJJJJJJJHHHHFFFFFFFCECD>ADDDD;ACCD#
@6CE
AGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAA
+
CCCFFFEFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJBFHBGFHIJJJJJJJJJJJJJJJJJJJHHHHHHHFDFFFFFEEEEEEEDDDDDDDD
@6CF
GTCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJIJJJIJJJJIIJJJJJJJJJIJJJDHHHGHFFAEDDCDDDDDDDDDDDCDDDDDD#
@6CG
CTGATTTGTGGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGTTTTGATTTTCAAGCACTGCCACTCTGTTTTCTAAACATTTCACN
+
@@@DDDDDCDFHHI?FGIG>HHAEHGHG@FAFFIGHI@D<<CGCG@GGFHIF<??DDDHACHHIIIGHG=CFCE7=@EEEH;B)?@D>B@@CC;CCCDEA#
@6CH
GGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCN
+
@@@FFFFFHHHHHJJJJDDDDCCDDCD>ACDDEEECCCD8CCDDDDDDDDDDDEDDDDDDDDDDCDDDDCDDB>BDCDDDCCCDCDDDDDDDDACDDDDD#
@6CI
CCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
CCCFFFFFHHHHHIJHIJJJJJJJJIJJJJJJIJJIJJJJJJJJJJJIFDHIGIIJJJJJJHIJJJJJJJIJJJJIIJIIAEHHFFFFFFEDEEEEEE
@6CJ
CTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTN
+
CCCFFFFFGHHHGJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJHGIJGHIJJJJJJIJIJJJJJIIIJJJIIJJJJJJGIIIHHHHHHFFFFEEDEEFE#
@6CK
GACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTN
+
CCCDFDFFHHHFDAFHIIIIG?CFHIIIEHGGICGIIIIIIIGGAHGHGHHGGGGFFF?A@@@?@BBC<@B@CCBCCCCBCDCCDCCBBBB@BC@BBBCC#
@6CL
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
CCCFFFFFHGHHHJJJGIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFEEEEEEDDDDDCEEEDDDDDDDEEFEDDD#
@6CM
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJJJJJJJJHHHHHFFFEEEEEEDDDD=@BBDDDDDDDDDDDDDDDDDDD#
@6CN
TTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCN
+
@CCBDDFFDHHHHIIJJIIJGCHHG@F@HHIJGBGHIGECFGGIGIIIHIJEHGIJIIJIIIEGGIICEDHEA@HIHHAEHAH>@@CB<AAECECCCCC@#
@6CO
CAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCACAGGCN
+
???1BDADCDD10CEA@EEE;CD90BDDDA>@DCCDAB8=CCC937>D3ACDA=>?@@A@???=??<<?==???>>?9?>A<39<A:>>8<>?<:<4>>>#
@6CP
GTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGN
+
C@@FFFFFHHHGHGIJCGGIJIHJJJJJJJJJJJJJHIJIJIHHHHHFEFDEEE>AABDCBCCDEEEDDDDDDD<CD>BD?CDDDDDDDDDDDDDCDDDD#
@6CQ
GGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTN
+
CCCFFFFDHHGGFGIIJJIJJJIJJIJJJJJJJJIIFHIIIFGGGIGJJIJJJJIG?EEFDD=CCDDDDCDDDDDDDDDDDDDDD?@DDBCDDDDBDDCC#
@6CR
GAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCN
+
@@@DBEDDHHDHFJEEHIHIJJJJJJJIIIIIIJIJJJGGIIJCHGHIIJJGFIJIGGIJIIIIHHFEDFEEDECDBCBCACDDDD=@BCDDDECDDDCD#
@6CS
CCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCN
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJIJJJJJJIGIJJFIIJJJJJIIJIJJJIJJJIJJJJJJJJJJJJIJJIHHHHHFFDEFCEEEEECCDDD#
@6CT
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
@@@ADDDBFHHDHIIIGEBGFHIIHGHG:CD6BFEFFGHGIIGIIEGC@FHIGGEDAAAB??CC>>@C;@>35>AACAD>@>@A@>ACC>:9C<CA73>@#
@6CU
GCCGACCGCGCATAAACATTTTAATGTATTCTCCTTCTTGGTTGAGGATGGCATCTTTATTTTTGTCTGCAGTTTTGGGAACTTTTGGTATTGATTTCGGN
+
=1=++0)))<<C1C4:9?DBDD4*?*009?*****0*08DD)=B3).)8)()77?C7=A>).7;,6;3>@>6>>>>=?/9:8(::3(&((4((((44((0#
@6CV
CTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGAC
+
@@CFFFFFHHFFDIJIJJGHEHGEGIJIIAEGHJJIHIIJGGGEGIJDHIIEGGGHAFCHHIHGIBEEABB?CCEEA6>CABDDDDDDDCDDACDDDDD
@6CW
CTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCAC
+
?@@DFD<?FHHDBHBEGGG?FEGGIIIIIIDDBGGDFHEGEHCBHGCBFFHIGHGIGHGGGD>5=B@CEE@>;@DCCC:;;@C3@3@@595?:@::AC
@6CX
AGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGG
+
@@@FBEDDHFFFDHG<FBGGEDC0D>BDBFHB99DFGG<8)?;;CCF<BHBFDC>A6;;@ACCC:>;C>:>AA9@95<@:@:@:>>>C@:9@BBB?<98
@6CY
GTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTTTAGCA
+
@@@FFFFFHHHHHIHHHJIJJJJJJJJJJJJJJIIIIGHJJJJJIJJJJJIJJIIJJJJJIIJJIIJJJJIIIIGHIJJIJEHHEHEEFFFDDDDDCCD
@6CZ
GCCTTCTGAGAACACAGCTCATTGATGTAGCTCAGGAGACCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATN
+
CCCFFFFDAHBHFGHEGGIICGGGCHHIGIG@HEGG@FCFEFHEFFHDBFDBFGGIGHIGIJJJJGEDGEHHGFGHHHFFFFEEC@@CEDCD@CCDDCCD#
@6D0
CTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTN
+
BC@DDDDFHHHHHIGIGIHIJIIJJIGCCEEGFGHGHIIFFGHGGIII9?FFGIHJJFIIJJIJJJEGHFFFFFCCECCCEDDEDDECCCDDBDDD>CA>#
@6D1
CGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGN
+
@@@DDDDDBDCDF<CGBFHHGGHGGHIGGIIGGEHGEGBFBFG=FGIIIFEAHFF;BB>ACEC;A??=C@@DCD>@CA8?<><B09@>CDCDADCACCCD#
@6D2
CTGATTAGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATN
+
@@@DDDDDF?ACBFCEGBFEB?+<AEEDBCDFF@CFC???:6DBBGCDG9DFDFFIBFDCFEBFIIC;CF@AEIIIECAEEBB;7?7;>A>6@@@A@5;;#
@6D3
CTCTAATCAAGTCCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJGJJIJJJJJJJJJJJJHIJJJHHHHHHHFFFFFF#
@6D4
GTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCTAACAGAGGAGAAAAGGAATTGCCTCTGCTCCCTGCCTCTTGACTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIIJJJIIJJJJJJJJJJHIJJJJJJIIJJJJIIJJJJJIJJJJJJJJHHHHHFFFFFFEEEDEDDDDDDDDDDD#
@6D5
GCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTGAAAAAAAAAAATN
+
;88BB??DFDD>?FB?6E8ACFBEFFGICB4CF@BGBF?DADF?F9;DEFFEF<=CB;F1---6=)7=76?B>;6>?>/28::5@BA:(:A>?0505&5(#
@6D6
ATCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
?@@BDADDFD>DF9EHHCFGBHI8HE9C<<DGF<D=9DCG3?>F<)B=CE>CAGG@G@ECCCCEB?,=?>:5@CC>?BBBBCCCCCCA@CC:AB<<B5(2#
@6D7
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
CCCFFFFFGGGFHEGIIIIGCFGGA<EGHC?D@FFCHGIGFGDHHEHGA@FHGHEGHCEDEEFHDDE3>CCCCAEED@A@BCCDCDDDCDDACDDCBDDD#
@6D8
CCAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATCCTCTTCCTCTGCTTCCTTTTTCTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTN
+
@@@DFFDD:CBHFGDDH<AHIIIIC<F<EDH@BFIIIGIIGEHGEGICHGABHGEHIIICCCFHGIICEFII@A3@DEAC=?C>B7).>;AC;@@=?CAC#
@6D9
CTCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTTGCTGTCCTAAAATCTCATGATTATAATN
+
@@@DFFFAHFHHDHHEHGHGHICHGGIHGHGIIIGGGIGHGIFHHIIG?FGIIB;FEA=BFEG=C>FEGGECCHEEHHHCEFFFFFEECC>CCCDDDEED#
@6DA
CTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATN
+
CCCFFFFFHHHHHJJJJHIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFDEEEDDDDDDDDDDDDDBBDD<ACDDDDDD>BDDDCCD#
@6DB
TGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGG
+
@CCFFFFFHHHHHJJJJJJIJJJIHIJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJDGIIFHHHHHFFFFFFEEEDDD;@BD>CDDEDDCCDD
@6DC
ACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTAACCTGCCGCCTTAAATCACCAAGGTCTTCTAGCAGATCGGAAGAGCACCGTN
+
@CCFFFFFDFHHHJJJJJIJJJJJJIBFHHIJJIJIJJIIJJJIJHIJJIJJJJIJJJJIJIJJJIIIJJJJJ@CHHHHHFFFFFFEDDDDDDDDDDDDD#
@6DD
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATN
+
B@@FFFFFHHGHHJJJCGIJDHIJCGHJGIJJGIJ?HHIJIJJJJJJIJJJJJJJJJ@EHGGHHFFFFBCEEEEEDD@BDDDDDDFDDDEDDDDDDDDDE#
@6DE
CTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCN
+
CCCFFFFFHGGHHJJJJJIJIJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJHHHHHHFFDDDBCDDDDCDDEEDDDDDDDDDDDDDDDDDDDDDDD#
@6DF
TGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGN
+
CCCFFFFFHHHHHJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJFHIIJJJJJJIJJIJJJIJJJDHIJHHHHFFDD=BDDEDDDDDDDEDDDDDDDDD#
@6DG
CGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTN
+
@@?DDDDDHHHHGEEGIII>CHHIIIEGGIFIIEIDFHIIIGICEHIGGGEHGGEHIBECF>FGBCGGGCG@HGAGG@DEECHFECDEBDD@CEE@CACC#
@6DH
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGACN
+
<@@DDDDDFFDHFAFFGGGG@BEFGECEIEEHDDGGE?HBD>DFHG?BDDGHGIFDHGIDHIIIIGIIIACHEE>BBBCCDCB?@<?ACCCB@B?BB???#
@6DI
CGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
CCCFFFFFGHHHHGHJJJIJJIJIJJJIJJJIJJJJIJFGIHGIGIIGIJJHIJIIGHJIIIJIIJIHGHHFFFFDD6<B3<?8?@ACCCDCDCC:@C@B#
@6DJ
CTGGCTCCTCTTCACGTAGGAATCCTCTTCATAAACATCTCGGGACAAGCCGAAATCCGAAAATCTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTN
+
??=ABDBDHDFHHGBHEFAGGEFIGGIGGGHIHGGGGIGHIIFEAHDDGIGGGGGHGCEHEBFCACCDAD@AA@C3>BBB?B?9@CCCCCCB<C>:@@>@#
@6DK
CAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAGCCATGGGGGTACCTCTGTCATCTCCCCACATGGCTCCTGA
+
?@<DBD?DHBF?DBFEFHGEEIG@GHHCADGGGGGGGD>9B?/?B>>A>BFIGCFFEGHECCCCACD=@CC;>A>AACD@@CCCB?BBA@AB?C?CAC
@6DL
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATN
+
CCCFFFFFHHAFFIGGHIG<CFHEIIGGHGIID<DCGCDFHCHBFIEIGHII@CDGEDHGHHHFBBEE@EDCECACCDDCCCD<CDDDCDDDDCCCC@@C#
@6DM
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFDFFHHHGHJJJFGHHIJJJJIJJGIFFHIJJIJJIJJJEIJIJIJJJIJHJJGIGHHGIIIIHHHGFFFFF?ACCCEDD(:?B>ACDABD8?C
@6DN
GGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTN
+
@C@FFFFFHHHDHHJHIJJ<CGHHIJJJJJDGIJHHIIJJJJJJIIJJJJJJBFHIJJJJHHH7?CFFFFDDDDDDDDDCFDEEEDDDDDDDDDEDDDEE#
@6DO
GTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGG
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJJJJFFGGIJJJIJIIJJ@FIIJJJIHHGHHHHFFFFFFECEDDDDDBDCDDDDD
@6DP
GTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTN
+
@@?DDFBFFHFHFHIDHGHIGHIEHIIGJJCFBGHHGFEEHJIIIGDFEFHIIIGHJGIIIIGIG;AGEBDF8;@=A@>>;@CCDDC@>:5>AC5AC@CD#
@6DQ
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJIIIJJJJJJJJJJJJJFHIIJJJJJJFFHAAHIJIJIJJJJCEHHGHHFFFFFFEEEEEEDDD;@BDDDD?C#
@6DR
CGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGN
+
@@@ADDDDHDFB<FH@GBDHGGEGB?G<CEGIIIIIFDFG?FD8?6@@FGGCIH;;@G?CDE?B;>;@A?CACCACAACCCA@?<:@CC@CC@>@::@>@#
@6DS
CTCGGGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATN
+
@@@DDDDAFHHFDGHGGEHGGIHGEGIGGGGDHIGDHIIIIIGFFBFHIIIEHAHAGAEHC=AC?C?BD@CACAEDCD5;>=CD>CCCA@BB??>CDD@C#
@6DT
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
CCCFFFDFHHHHHIJJJJIJJJJJHIJGHJIHJJJJJJJJJJJJIHIIJJJJJJJJIJJJJJJHHHFFFFDEEEEEDDDDDDDDDDDDDDDCD@CDDDD
@6DU
CATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGN
+
CCBFFFFFHHHHHFHIHIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJHHHHHHFFFFFFEFEEEEEDDDDDDDDDDDDDDDDDDDDDDDDEDD#
@6DV
CATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTA
+
CCCFFFFFHHHHHJIJIGGHJJJJJJJJGIIJFDGHIIJJJJHGIIHIIJJIJJJIIJJJHHHHHHFFFFFFFFEEDDBBDDDDDCDDDEEEDDDDDDC
@6DW
GGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTN
+
CCCFFFFFHHHHHJJJJJIIJJHIJJGIII1CGGGIJJIIJFHIIJJJJJJJJJJJJJJJIJHAHFFFFFDEED@CDDDDDDCDDDDDDDDEDEEEDDCD#
@6DX
AATGCAATGATATGTGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGCATAATTN
+
C@CFFFFFHGHHHJGGIJJIIJIGIIEGIJJJJIGIIIJJJJJJIIJIJJJEIJJJJJJIJIJJJJJIIJJJIHDEIJJHHHHHFFFFFFEEEEEEECCD#
@6DY
GCCCCTAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJIIIJIJIIIJJIJJJJJJJJJIJJJJIIJJJJJGIGIIJ>EHHIEHHHHDFFEBCEEDEDEDDDDECEDDDDDDDC#
@6DZ
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
CBBFFDFFGHHHFIJJJJIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIIJIIGIJJJJJJGHHFHFFDDDDDDDDDDDCCDBCEDCDD
@6E0
CCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJIJHGHHHHHHFFFFFEEEE#
@6E1
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATN
+
CCCFFFFFHHHHHJJIJIJJIJHIJHJJJCGIIJIIJJJJJJJJIIJIGIIJJEIJJJIIGHFEHFFCCCCCEEBD@CCDCDDDDDDCDDCDCDDDDCCC#
@6E2
GGCTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCN
+
CCCFFFFFHHHDFGEGIHHIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIIJJJIIHHHFDDDDDDDDCC@CDDDDEEDDDDCCDDBDDD#
@6E3
GTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATN
+
<?@FDAFFHHHHFJJGIEHJIIIHEIEIJJJGHAHGGHGCFHGGDEIIIBFEEGDGI>BHG<DGIGGGGGIJJIGGGIGGFCHEHH@@DEFFCCDEDC@C#
@6E4
TGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCN
+
CCCFFDDDFBDFHGHIIBHDEHGIDHCFHHIEIIIFHGGGHGF>GHEIIIGHGEE@CFHD@GIGHIGHICHHHG?DDDFFFECECCCCC?BB;@B,>@>B#
@6E5
CCCTGCCTGGATGGGAGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGN
+
@@@DDDADF?FHHFI+AFGDGIGBEEGGGIHIIGIGGHEHGGIIIIIIGI@FGEHGHIGAA@@CGCHEEFBDC>B@CDCC?BBB8AACC@DACCCA?CBB#
@6E6
CCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJGIJBGHIJJJJF>BDDDDDDDDDDDDD?BDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDDD#
@6E7
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
@@@FFFFDHFHDHFHJIJIJIJJIJJIJIIJJIJJJIJJJJDGGHGHEHIFJGIGHIJJIIGGIGIFHEFHDFFFDDEDD>?B88:>@C>@C:4>>AC4?#
@6E8
CGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAA
+
CCCFFFFFHHHGHJJJJJJIGJJJJIJJJJJJJJJIIJJJJJJJIJJJIJJJJJIIIJJJJJIJJIJJJIJJJJJJJIGHGHHFDEDFFEEEEEDDDDD
@6E9
CCACACCCAAGGGTCCCGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCTGTGCATCCCN
+
@CCFFFFFHHHHGGHIJIIJJIIJJJJJIJJJIJJIIJJJJJJJJJIIJJJIIHIIJJGHHHFFFFFDDDDDDDDDDDCCDDDDDCCDDDDDCDCDDDDD#
@6EA
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
B@BDDFFFHHHGHJHGIDGHCFHJJJJJJJIIJJJGIIJJJJJJJJJIJIJIIIIJJJIIJHIIJGIJHHHFDDDDDDDDDDDDDCCDDDEDDCBDDDD
@6EB
CCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJJJIJJJJIIJJJJIJJJJHHHHHHHFFFDD=@DDDDDEDDDDDDDDD#
@6EC
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
CCCFFFFDHHHHHJJJJJJJJJFHGJJJJJJJJJJJJGIJJJJJJJJJJJJJHIJJJJJIJJJJIIIJJJJJJIHHHHHHFF?DCDDDDCDDEEDDDEED#
@6ED
CTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGAC
+
@@@DDDDDHH>F?FHAEHIFCGHDHBHDE???GD@D:??BGGB8?FHDDFGAGHCB;AFC=).7=C=;CDD2;ACCC(6;-;?BCA@CCCCC:@@>5>4
@6EE
CGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGG
+
CCCFFFDFGGFFHIGIJJJDHGEHIGHJJGGG?DHGIHIJJGI=FGIJJIBEEED;BCCDD;?;CCDCCCDCACCDCDDDDDDDDDDDDCDDDDCCDDD
@6EF
CAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACN
+
CCCFFFFFGHHHHJJJJJJHIIJJJJJJJJJJJJJJJJJJJJJJJHIIJIJJJJJJJJJJJJIIJJJJJJIIJHHFFDEDDDCBDDDDDDDDDDDDDDDD#
@6EG
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
@@@FFF?@HHDF@EBFEHHIIIIIEEFEF7?CFDHHIIBHHIIIFFGGHIJIJIJGGIIB@CEHEFEFEF=@CACEDCDBD@B@@BDACCDCDCDD@CC
@6EH
AGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGN
+
BCCFFFFFGHHHHJHIJJJJJJJJJJJJJJJJJJJIJIIJJHHHHFFFFFDDDDDDDBDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6EI
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCC
+
@CCFFFFFHHHHHJJJIJJJJJIJJJJJJJJJJJJJGIJJJJJJJJIJJJJJFHGIGIJHHFHFFFFFDDDDDDEEDEDDDDDDDDDDDDCDDACDCCD
@6EJ
GTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACN
+
CCCFFFFFHHHHHHHIHEHHHIJIIIGIGIJHIJJGGHHIIJJJIJIIJGGHJJIIIIHIGGGHHFHFFFFCEAC>CCDBCBC@C>CCBBBB<CCCDDDD#
@6EK
GTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTN
+
CCCFFFFFGGHHGJJJJIJIIIJIJIIHGJJJJIIIHIJJJJIIJGIJIIJJIHGGEIIIIIJIJJJHEHEIJJIJJFIIJEHIJIEHHEHHEFDDECFF#
@6EL
GCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGN
+
@@<DDDDDHF<D??BFHGGFHHIGDE?FGH?<BDDDF8BBHHI:@G>GC@GHBHFEEDECEDCCCCCCCCCCCCACCD@@>@ACCCCCCCECAA@3>AC?#
@6EM
GGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTN
+
:=1=B33?AB:3:;;@6C@EEEE>E>D:?DABDC099BDD@2228<A@A>>;7?CDD;?))7@>;>',;?2892:3>(4:>:>4>ADAAAA>>>>58(3>#
@6EN
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTN
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJJHIIJJIJJJIIIJJHJJJJJJJJIIIJJIIJJHHHHHFFFFDEEEEEDDDDDDDDDCDDDDDDDDDEDDDD#
@6EO
TGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATN
+
CCCFFFFFHHHHHJJJCGIJJJJIIJJJJJJJJJJIJHIJJJJJJJJJJHHEFFFFFEEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDEEDACDDDDEEE#
@6EP
TGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGCCTTGGAGCTTGGCTGTAGGATN
+
;??DD8=B>D84DE9+A:AB+A;4A3A+)):9?DD6DA@DDDDBBBBC=BCA4;@7)=A:?>3?)).6>=@@AA3>>3(-5>33:<395:59>083:>(:#
@6EQ
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGN
+
CCCFFFFFHHHHHJJJJJJJJHJJJJJJJJJJJGHJJJJJJJHIJJJJJJJJJJCGIJJHHHHHGFFFFFFEDDEDDDDDEDDDCDDDEEDDDDDDDDDD#
@6ER
TCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJIJJJJJJIIJJJJJJJJJJIJJJJIJIJJIIJIGGIJIJJJHHGHFCDFCFFEEECE#
@6ES
GGGGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATN
+
@@@DDDDDDHDDF;FEFBFHHBFAECFDGFHHGIIC@?F@GAHGGGIGGGGEH@B<@;;@EGDEEEDB>DE@C@AC@A>@:>>CB>AACC@DCCCACCAD#
@6ET
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
BCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJFHIJJIJJJJJIJJJIJJJJIJJIJJJJJIHHHHFFFFFFDDECDDDDDDDDDDDD@CCDCDDCDD
@6EU
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
@CCFFFFDFHHGHGHIGIJJJJJIJIJJJIJJJJJJHHDGGHIJIGIIIJIJI?FFGFHII;CEHEHHHCFF5?CEECCDDDDDDCBD>CCDDD<@DDDD#
@6EV
TGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCN
+
CCCFFFFFHHHHHJJGIIHIJGHJJJJJJJJJJJJJJJJJJJJJGHIJIJIJJJIJHHHHHFFFFFEDEEEEDDDDDDDDDBDDDEEDDDDDDDDDDDDD#
@6EW
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@C@FFFFFHHHHHJJIIJJIJJIGGIJJJIIGIIIJJIHIJJJJJJJJJJJJIGGIJIJJJHHHBCDDDDDDDDDDDDDDDCDDDDDDDDDDBBDBDDDC#
@6EX
CCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACN
+
?@@DBADDFBFAD<CFHGFFEDHHHGGGG?EF=GHA?FGE9BFHIIIIHGIDHGGHBH?BEEEECCCCCC@CCCCCCDCCDCCCCCAACCADDD@CCCCB#
@6EY
CTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACAGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTN
+
CCCFFFFFHHHHFHIIJJJJJJCHHIJJIJJJJJCGHIJJJJJ?FIIJJJJJJJJJJJJJJJJ@GIJIHHHHHHFFFFFFFEEEEEDDDDDDEDDFEDDD#
@6EZ
GGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCN
+
CCBFFFFFHHHHHJGHIJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIJJJIJJJJJJJJJJJJJJJJJJJJJJH?EFEFEEEDEEEDDDEEDDDDDDDDD#
@6F0
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJ=BCBEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDC#
@6F1
GTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCN
+
CC@FDFFFHHHHHJGGIGGIGIGIGGIJIJIGGGGHJIIJJIIGIGGIJJJJIGIIJJJJIGIF<@?CEDDDDCC@BCCDDD@BCDDBDDDBA>CCDDDD#
@6F2
AGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGN
+
CCCFFFFFFHHHHJJJJJJJJJJIJJJJJJJJJJIJJJHIJJJJJJJJJJIIJJJJJJJJIJJJJJJJDGHHHHFEFFFFFEEEEEEDDCDDDDDDDDDD#
@6F3
CGGGACTAGGCGTGTGCTGCTGGACATGACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJDDDDDDDDDDDDDDDDDDDDDDDDDDDEEDDDDEDDDDDDDDDDDDDDDDDDDD
@6F4
GGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGC
+
?@@FFFFFHHHFHHJHIIJIGIEIIIJJJJEDGIIIIGGGIIIJJIIHIIG.=C@GEEFFFDDADDBBDB@B:?CE@C@CDDDDD@CCDDBB?B><9@B
@6F5
TGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
???DBAB;D?D?D:E?E??BF4:F:9F<<+@9E4:E??881)000?9D?90?//?D@E:=CB8/8.=).).)..?7=?=@D8,,(5;-5--(;(:(>:5
@6F6
GCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGN
+
@@@DB?BB??BBAA<A21<FGE?CGGIB::?BF90?;9BB7D?B9??FFFF@@F6FC=@77CC>C?;5??BC5;===?BB8?@@B@A::9<<95>BB34>#
@6F7
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@@CDFFFFHFHGHJIIIJJJIIJIGIEGGHHIJIGJJIIIIIIFGIJJIJIGIIIJJJJIJEHGHHHEFFEEA?>CDDDCCCDDDDCDDDDCDDDCCD
@6F8
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@?@D?@DA;DHDBCAEDCHGE@:?CF@??FDGHIIIDHIHIABB=FACBDG@FAGHCHAHHHHEEDB>:3:>CACC?B5?BCCC@:A>CC@>CB@<95<8#
@6F9
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
@@@DB:D2222<AFEE@EGBGA<C9C<C2CA?C??<?11*1:DG)BDB<F@FF8DF?488.==48=FFCFAE9C=..7.7?;BD?9>5?B@>ADB>B>AA#
@6FA
CTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJJJIJJJJIJJJJJJJJJJJIJIJJJJJJJJJJJJJIHHHFFFFFEDEEEDDDDDD#
@6FB
CTCTGGTTTGTGAAGGAGCCATTGCCTCTCTCTCCTCCACGGTCTTAGGGATCCCAAGGAAGAGAAGTGAGTGTGCGACCGAGCTCAGGGCCCAGGCTGGN
+
CCCFFFEFHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJIIJHHHHEFFFFFFEEDDDDDDDDDDDDDDDDDDDDDDDD#
@6FC
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCN
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJHHIIJJJFGIJHIJJJJJGHJJIIHHHHFFFFFDEEEEDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDD#
@6FD
GGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTN
+
@@CBDBBFHFHDHH<BFHGFHGGGGHDGGIEGACHG?@GIGG?FHHGDFDHGIJJGCHEHHEEA?EHHEDBDEFCCACDEEDDECDC?@BDD?CBBCCBD#
@6FE
TTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTN
+
<@<DDDDDFF<:A?CGAGCC>BEBFGHII?EHE>DFHCH?FHEDFGIIIICHI?FBHIIAEFHIGIIGGGGHGGEHEE7?=CDB;AACC>A@?;==?:?B#
@6FF
TAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGG
+
=@@;DB?==FAHD<@@8?AGAHGHIH?D>?BBEB*:BFF9B?F8BDGHGCH=8CD@FGEIIIFH==BEEEC?;>@B=@9AAC@@ACABBBB<@59@CC
@6FG
TTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGN
+
CCCFFFFFHHHHHJHHJJJJGIJJJJJJJJJJJJJJJJJJJHHHHHFFFFEECEDDDDDDDDEEEDDDDDDDCDDDDDBDDDDDDDDDDDDDDDDDDDCD#
@6FH
GGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGN
+
@@@DDFAD<CFHHIGGEEEIIGGDFHCF:<E:CFFGIIIIE:?;BC<FAFFC@GAEACCEHAEF9<AB5;@@;>C@:A=8=??3@CCC@<CC::>5??5>#
@6FI
CCTGGGTATAGCTGACATCAGTGGGCTGTCTATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGGGTGGGCTGGGCGGTN
+
???DAD:BDD>D,:AEEEEEEC4:CF>62<**1*@C1?*9D*:BAD<B?009*00??D<B)=<<BC)5@5=A7=AC:7;);7.>A(6(39=79=818>9)#
@6FJ
GCAGTGGTCTGAGCCTGGGTATAGCTGATATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
BCCFDFFEHHHHHJIJJJJFFHIIIJJJJJJJJHGIJIIJIJJJJJIJJIIJJJJIGHIIIJGHIJJJJJJJJJIJHHHABCACECCDDEEDDDEEDD
@6FK
CGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGN
+
@@@DDDDFHHHGABCCFFHHHHHIIGCHIHIIJCHBFGHEDH>FHIJBHEDHH<GGGHIJJEADDHGHC>??E@7;CB>@AB(;??CCC?CD<8A@CCCC#
@6FL
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJHHJJJJJJJJJJJJJJJJHHHHFFEDDEEDDDDDDCCDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@6FM
CATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGN
+
@CCFFFFFHHFHHGIEGGAFIHIJIIGIJIJIIIHIGGGIIJJGBHHIJJIIHIJJIGHHHHFFDDFFDCA?8?CDDC@CDDDDDCDDD>AACCC@@BDB#
@6FN
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
???DDDD:CDD?AEB;BEIII8CEE9??DC:?9::0:BDDC=>EIIA@B=CC>AADDDD@C@D>CA@A;@@@<>;;?55-55>:5>A>(59:>+4>499
@6FO
CTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGN
+
CCCFFFFFHHHHHJJJJHHIJJJJJJJJJJJJJJJJIJJJJIIIJJIJJJJJIIHHFFFDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6FP
CGCTGCTGTAAATCTTTTAGCTTTGAAATTTCCAAAATTAATTGATTCTGCTTCGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACN
+
11+4482?=4?BFGGCFBB+3<3,A3++2AA?<A@?B<EGGEGF49?DF?>?B*009DA>?FG8B>==<CFGII>G:C)=).7?6=3?@@B@DEECA;=A#
@6FQ
CATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTN
+
CCCFFFFFHHGHHEIIIJIIJIIJJJJJIIJJIIIJJJJJJJJJJJJJIJJJIIHJHIIJIJIJIJJIIJIJJJJJJHHHHHHHFFFFFDEEEEEDDDDD#
@6FR
AGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGC
+
@@@FF=BDHHHHHJIIJJIJHIJJIJJIJJJJJJIGIJJHGIIJJIHGHIFHIJJJGFHHGHFGIHIJJHHFFFFFFCEDEEEEDEEDDDEDCDDDDDD
@6FS
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
CCCFFFFEFHHHHJIJJJJJJJJJJJJJJGIJJJJJHHGGIJJJJJJJJJJJJFHIJHIJJCGHHHHHHFFF=AEEECDDDDDDDDDDDDDDDD@BBDDD#
@6FT
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHHHJJIJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJCHIJJJ:AHHFFFFFFEEEEECBD;CCDEEDDDDDDDDDCDDD
@6FU
GCCGCCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTN
+
@CCFFFFFHFHHDG?EFHIIIIIIEHAFGHIIIIIIGGHI8@DHGIIIIIIIIIDDD<@B;@DDDD08BDDD9>BCEEDEDDDDD9BDDDD9>@<?@C@C#
@6FV
GCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHGHHJJJJIJJIJJJJJJJIJJJJJJJJJJJJJIIJJJIJJJJHHIIHIJJIJJJJIJCEHFHHFHHFFFFFFEEEDEEDDDDDDDDBDC
@6FW
CCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJDHIJJJHHFFFFFFDEEEDDDDCDDDDDDDDDDCDDDBDDDDCDDDDDD<BDBDD#
@6FX
CTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTN
+
@@@FDDBEHBFHGBBHIBHIIGEGHIIIHGHIEHHGGGEGHIGDGGIIIIIIIIHIIIFHHCHIIIIG@FECGHGGGGGGIEACEGFFHHHEECFFFFED#
@6FY
CCTTGACCACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTN
+
@C@FABDDFFHGHIIGEGIIBHCHHGIIGHGGII@D:CHHEHIGA?BDFDHIIFBBFIGD@HIIHGDEEEECCCACCCCCC;;@@CACCCA@C@CACAA4#
@6FZ
TGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGN
+
BBCDFFFFHHHHDHIJJJJJJIIJGJIJJJJJJJIJDHHIJJJJJJJJJJJHHHHFFFFDDDDDDDDCDDDDDDDDDDBDDEDDDDDDDDDDDDDDDDDD#
@6G0
TTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTG
+
@CCFFFFFHHHHHJJJJJJJJJJJIIJJJJJJJJJJJJJIJIJIJJJJIJJJJJJJJJJJIJJJJJJJJJJIJIIJIIJJJJJHHHHHFFFFFFFECEE
@6G1
CGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTT
+
CCCFFFFFHGGHGJIGGGJJIJJJJIGIJJIJJJGHIJJJJJIJJIJIIIJIIIJIIJJCHFJIIJGIHJIIJJJIIHGHFFHEEDEDFFECEEEDDA
@6G2
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFDFFGDHHHJJIJIJIJJJJJJIJIJJJIIJJDHIGJGIIJJJJIIIIJJJJIFIJJJJGGIIHHGHHFBEDDFFDDB3=BDDDDDEDDACBDBDD#
@6G3
GGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCTATTGTGTTTATATGCN
+
CCCFF@ABFHHHHIJJIJGGEHGIJJJJIIGIHJJJIIIJIJJJGGIIJIIGDHHGIJIHHHHGE@EFFFFDEEEECCCCB@CCCDEEDACCCDAACDCA#
@6G4
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
@@@DDDBD?FFFHGICAFCD<29ABEE@9CD@=?D?FHG?AGH3B@@;==@87=;=AA>:77==?CB62;=AC<@;;5555((;<35>(55:?3@>@>
@6G5
CATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCN
+
@CCFFFDDFHFFBHGJJJEEFGGGIIIEHDDHIIEGGHIIGIJHIJEHDHIJIHDCHFBFCEHGIGDED@@BDDDDCCDCCFDCDDDDBDDCD@BBDDCA#
@6G6
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@@CFFFFFHFFFGIJIJJFHIIGIGEIIIIEHIJGGIIGHGIJCHJIIJJHGIIIIBGIIJJJ@EHF3>CCECDCDDDB@?BDDDCCABDDCCCCCDDCC#
@6G7
GGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTN
+
CC@FFFFFHHHHGIJIJJIIJHHJJJIGJJJJJIIHHIJJJJJJJJJJJJJJJJJIHHEFDACEEDDCDDDDDDDDDDDDC@CDCBBD<CBDDD9<?@CD#
@6G8
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
@@<BDDDEHHD?DIGGGFAFFFCHHEII>FHEIIIEEIGB@9DDHCCDG:FHHBHI.;;;;;-;=?@>?CCFEE>@A;=B;@>>CD>>CCCDDD@DDCD
@6G9
CTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJIJIJJJJJJJJJIJJGIJIIJIJJJJJJJJIJJJJJJHFBEE@DCCEDDDDCDCDDDDDDDDDDDDDB#
@6GA
GCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCC
+
CCCFFFFDHHHHGIGGIJIIIGGIIJCHIIIJJJHIIIJHGIICGEHHIGGIIJJIIHIIIEHGIGIJJJJJGIJIHGGHIFGHCEHFFEFDDCEEDE
@6GB
CCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCN
+
C@@FFFBBCFHHGGI>HBFHEEHIEHEGIIIEGCHGDE??DHHGDCG?FHHHGGGICHIHIII>GIIIEGIICHGC@EE7A??CDFFBE;@>CEE@EECC#
@6GC
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATN
+
@@@FFFFFHHGHGJIJFGHIDFGJAFGIEGHIGHGFDHIJJJDIJIJJIJIIIJIIJAEHHHHHFFFFBEEEEDEDDDDDDDDDDDDEEEDDDDCDDDDE#
@6GD
GGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGN
+
@@@DD:DDDHFHGI@GHCGCHCFHGGG?DFHGGIIIGIBDGIIEHEDCGA;AGGAGHHFHHH;BEEFAACC;@;CCACCCBBB<>:@CCCC:AC>ACC:@#
@6GE
CTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACN
+
CCCFFFFFHHHHHGIJJJJJIIJIJJJJIJJIJJIIIJJGIGIIIIIIJJJHHFDEEEDEDDDDDDDDDDDEDDDDCBCD>BCDDDDDDDCCDDBBDDBD#
@6GF
CGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
@C@DDADFHGFHHJGDDGIIIJIIEGGGHHIJIEHGGHG@GGIGIIIJJICHIJIIIIGGEHDEBDFDCCECACCC@CCCCA;ABAADDDC:CCACAB
@6GG
GCTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCN
+
CCCFFFFFFHHFHJJJJJJJJJJJHIJJJJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJHHHHFFFFFEEEDD9?BDDDDDCDDDDDDDDDDDDDDDDDD#
@6GH
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@B@DFFFFGHHHHJJJJJJJJJJJJJJIIJGGJJJJJIJJGIJJJJJJGGGIJIGGGIIGEIJJIDGHHGHHFFFFFFFDDD;@BDBDDDEDDCDDDBBD#
@6GI
CCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGN
+
CCCFFFFFHHA<AAEHHIIJJJJJJJJJJJJJJJJIJJJJJJJJJJIJIJJJJJIIIJJJJIIJJJJJIJGIEHGHDFDDEEEECEDDACDDC>CDABCC#
@6GJ
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJJJJJJIIJJJJIGIIIGJJIJIJJJJJJJJJJJJJJJJHHHFFFFFFFEEEEEDDBDDDDDDDDCCDDDDDD#
@6GK
GGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTAT
+
CCCFFFFFHHHHHJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHFFFFEEEEEEEDDDDDDDDDDDDDDDDDDDDDCDCC
@6GL
GTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
@@CFFFFFHHHHHJJJIJJJJJJJJJJJJJJJIJJJIJJJJIIJHGEHHIHIGIBFCGIJGGGIJIIGCEHFHGFDEF?EEDDDDEDDDC>@BB@BCDA
@6GM
GCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATN
+
CCCFFFFFHHHFFHHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJIIIJJJJJJJIJAEHHFFFFEDEDCBDDACCCD>ACCCA#
@6GN
GCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACN
+
C@CFFFFFGHHCFEHIGHGHIJJJJJJJJJJJGGDHIDGIJJJIJJJJGIIIJJJIJGIICGHG?@BEDD8>@CDDDDDDDDDDDDDDDDDDDDDDB8@C#
@6GO
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
@@@DDEFFDFDHBHGHCHIIEGHGGGCFHGGGGGGGBFGGGIIJIGGHHDEGBAAEE@CHEHCH7@DDDC@CDBDCDDDBDDCCCDCCCCDACD8>CCCC#
@6GP
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
CC@FFFFFHHHGFEGIIIGCHIIIECIGIEECFHEIJIJIJIIJJGIACDHEHEDFBCFGIJJ-:AD9AC@AAC5>ABABBDDDBCDDDBCCAC@@CDDD#
@6GQ
CACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGGGGAGCACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCN
+
1?8D?=DB<<<AD<,2A:C:<FFII?8C:8)C;D*91)000*9DDD?A7-54)=@3A;77?'53'3'(5,8?953>:><20-58>?A(5>?;00<9:(:9#
@6GR
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTN
+
@@@FDFFFHFHG?FIIGHIGA<CFBBBHG@FFBHBFHGFFHCGIG9BF:?BFG@DDHHBFBDG>F>B@G>CGH>GEHHIDDEHIGHEEHHEBBB@CCCEE#
@6GS
GGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCN
+
@@@DDDADACFDHHFHBHEHI?EGIICGIIIDGFGGDH;DDD9BBBFBBAG=FGGIIBHCGHHEEHHEFEFFFFFFDCDECEEDBBBB??B?CB@CDCDD#
@6GT
CCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCN
+
CCCFFFFFHHHHHIGGIJ@IEHIIGIEGIIJJJJJIGJJJJJJJJJIJIBFBFHIJIIJJIJJHEHJJJJJEFFFFEDEEDDDDDDACC>CDDDDDDEDD#
@6GU
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
CCCFFFFFHHHHHEGHJHIJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDEDDDDDDDDDDDDDDDDDDDDDC#
@6GV
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJIJJJGJJJJJJJJIJJIGHJIJJJJJJJFHHHIIJJJJIJJJHHHHHHHFFFFFFEEEEEEEDDCDDDDDB<C#
@6GW
GTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGC
+
BBCFFFFFHHHHHJGGHJJJJJJJIJJJIJJJJJJJJJJJIJJJJIJJJJGIJJJIIJJHIIJJIJJHHHFFFFFEDDEDDDDDDDDDDDDDDCDDDD
@6GX
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@C@FDFDDFFDBAGHB><FEHG6<?CCF>FAHICGGGHIIEH>BBCEHIIIGIGHEH@@BB>D@E:>CEC=@;;>@;B>5ACCCC>9C?C3(>>28>>>
@6GY
CGCTCTCCAGCGCTGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATC
+
@@CDDFFDHHGHFIIJJJJIIGHIJIJJIJJJIJIIJJJI>EHHGHFFFFEDACCCCCD@CDCCBBBDDDDCCDDDD@BDDDDDDCDDDDDBDBDDCC
@6GZ
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
CCCFFFFFHHHHFHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJHIIIJJJJJJIHIJJHH=ADD@DDDEDDCDDDDDDDDDDDDDDDDD#
@6H0
GTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTN
+
CCCFFFFFHHHHGJHIJGHIJJJJJJJJJJJJJJJJJJIJJGIIJJJJHIGHHIIJJJJHIJJHHHHHFFFFFFEEEEEDACDDDCACDCDDDDCDDDCD#
@6H1
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
@@@DDDDDHDBFF>AEHDFGIF:D*9:?DB;;;@<)9?<B<FG;;FEG)))7.==)).7=/9=>C;AC3>9A335>A>A3:??@+>@>@:?B<<9<(::@#
@6H2
GGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
CCCFFFFFHGHHHJJJJJJJJJJJJJIIJJJJJJJJJJJJIJIIJJIJJIIJJJJJJJJJJIIJIIHHHGHFFFFFFEDDDDDDD9;BBDDBBDDDDD
@6H3
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCN
+
CCCFFFFFGHHHHJHHIHJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJIJJIJJJIJJJJJJJJHHFDDDDDDDDCD>CCDEEEEDDDDCDDDBDDD#
@6H4
TCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCN
+
CCCFFFFFHHHHHJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJHHHHHHFFFFFFDEEEDEEDD#
@6H5
CTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTN
+
BCCDFFDFHFHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJIJIJJJJJIJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFFEEEE#
@6H6
GCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGN
+
CCCFFFFFHHHHHJJJJGIJJJJJJJJJJJJJJIJJJJJJJIDFHIIJFHIIIJIJJJJJHHI=CEAHFFFFFFFEDEDDDDDDDDDDDDDDDDDDDDDD#
@6H7
CTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTA
+
CCCFFFDFFDFGHJJGJJJHGIGJJJJJJIJIJJJGIIHHIGHIJIIJIJIEHGE@DFGGGJIJIJGIIIIJJIEGIJJIJIHHFFHH@CBDEDFEDCE
@6H8
CCTCAATTAAGGCCAAGGGATCTCTCTGTTTTTCTGGGGACAGCAGATCTGCCAGAAATTGAGGGTGAATGACAGCCTCCACCTTGGAGACAAAGACCTTN
+
CCCFFFFFHHHFHJJJJJJJJIJJJJJJIJJJJJJJIJJIIIIJJIHIJJJIJJJJJJJJJFIIJ?EHHHFFFFFDDEEDDDDDDDDDDDDDDDCDDDDD#
@6H9
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCN
+
CC@FFFFFGHHFFIEGHEIHIJJIJJJJIJJJJJIIJJJJJJIJJIJIJJJIJJIJIJHJJJIJJIJHHFDDDDDDDDCDCDCDCDEEDDDDCDDDB?BB#
@6HA
AACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTN
+
?@;DFDEDHHHHFGIEAGGHGHIIEGHHABFGHIGE@HIGGCFDH<F<BBGHGGBCGIC=)8CFHBHGIHADBDCCECECC3>C@C>@C:(5(55,5@@A#
@6HB
ATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCN
+
CCCFFFFFHHHHDBFHGHIIJGHIDFHEGGJFIJJJIGIJGJJIJJJGIIIJJJJIIJJJJGIJIIEGIJIGGHEHHHGDCCDFCEA@CEECCCCDEEEC#
@6HC
GGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCN
+
CCCFFFFFHHGHHJJIJIJJIIIIIJIJJJEIJJJJJIJJJHHIJIJJJIJJJJIIJJJJJJJIJJGHFFDDECCCDDDDCDDCDDDDDDDDDDDDBDDD#
@6HD
CTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGN
+
BBCFDDEFHHHHHJJJJJJJIJJJJJJGHIJIJHIJIJJJIIJJIIJJHJJJFHGHJJJIJIIIIHHIJHHEHEEFDFCDDEEDCDDDBDDDDD@BBBDD#
@6HE
CATAAAACTGCCTGGGGCCCTTTTCAAAGATACAGCCTTCTGTTCTGCTGGGTTGAGCCAGTAAGCCTTCTTGCCTCATATAATTGGAGTGGCAGCTAGGN
+
;:?1A+BA+=<2+<EE:EFD?EEDD?E?*1*1*?D3)):**?0?094?<**(/(-)).87A).7A)??C==);@A3;(.6;>:(.;;3=-,5(9?(((5(#
@6HF
TGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCN
+
CCCFFFFFHHHHGJJJJJJJJJIIJJJJJJJJJJJJJJJJJIJJJJIJIIJIJJJJJJIJIHHJJJJHBDDDBDDDEDDACDDBDDDDDDCDDDDDDDDD#
@6HG
GGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGN
+
@CCFFFDFHHHHDGGIGGIIGGIJIJEFEHIGGIGFEFEHGIGBDDBDDDDBCCD?BDB<@BDDDDDDDDDDDDDBDBBDDCB3>CDDACDD>CCCCCCB#
@6HH
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
@@CFDDDBFBFDDHBAFFFACEHBHB<A?AG>)1??@FEEAFDBBB?9D@)?BFFHABGIICH=@7.-56A??;7???C3;(6;-;CCCCCC5:@CA:@
@6HI
CTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTN
+
<<@DADDD:1ACAF<>FCF>E4FCEA4??EE<CFDF?1:?BGGEF=DFGAF;=3=CD;4)7.).=CE:=C?ADDCB8;8?>BB>:(:@BB@:::44:>::#
@6HJ
GCTGCGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGN
+
CCCFFFDDFFHFHJIJJIJJIIJJIHIJIGIIJIIFIGIJJIGHIIIJAHIIJJGHJJJGEHHADFBDFEEEEEEDDDDDD@CDDDDDDDDD@@BDDDDB#
@6HK
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
?@;=B=A?DD:B<CAF>ACFHIBGD?CGBGIBBDHICHIGIEFGGDEDHGIGGIIGII@)7@CHICE;??=?B;7@;>A>>ACC@;A;88@>???(59)2#
@6HL
TGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGN
+
@@?DDDDD?HHD:<?2A=HGCAFFBHFH4FHEBBCGHGHEE?DGCECD@HHIIIIIHAGFFEG@CHGA=ED>9>B9AAC@?4>>:@CCDCCC<(+9<<?B#
@6HM
CTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTC
+
CCCFFFFFHGHHCGIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJHGDFHFHIIIJJJJJJJJJJJJJHHHHFFFFDEDEEDDDDDDDDEDDDEDD
@6HN
CTCTGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@@?B??2B4=<AAEG<<<I?88@8:9:::DB?F?GDGF9?*000B?FF><FFBF18.)...=7A?=B<3,5-;--:8/3<(,>3+>(+++(++2?5&)++#
@6HO
GTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGCN
+
CCCFFFFFDFHHHFHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIIIJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFEEEEEEEEDDBDDEEEDDD#
@6HP
GGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGN
+
@@?DDB;DFB?<:F@EGF@<IEHEBH@HH@A<FDHHI@HACGHCHD<BBGDHFIIDGIHI@FBFHECHFCA;=CHE@=???B@BCC@C;??55>A@>CCC#
@6HQ
GGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATN
+
CCCFFDEFFFHFBHFHIJGIEFFHHGAFGGHIJJJ?FHDGIH@DHGGIGIJIGG@ACG<FFEAHCC;CAA??CB@?>CCB>?BABBB>CD><34>C>?AC#
@6HR
GTAGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACC
+
@BBFFFFAFHHHHIJJJJJIJJHHIHIJJJJJIJJJJJJJHIIJJJJJJJJJJJIJJJJJIJJIJJHHHHHHFFFFDDDDDDDDDDCDACDDEEEEDD
@6HS
CTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTN
+
@BCFFFFFHHHHHJIJGJJJIIIIJJJJJJJIJJJJGIHIIJIJJIJJJJJIJJHIJJIJHHBFGHGHIJJJJJJIIIJJIGIGGFHGEEHHFFFFF@DE#
@6HT
CGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
CCCFFFFFHHHHHJJJJJHHJIJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJIJJJJJJIHHHHHHFFFFEEEEEEACDDCCDD5?@DDDDDCDD<AD#
@6HU
GATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGAT
+
CBCFFFFFHHHHFIJIJJJHGHHHGIIIGJJJJJJIGHIJHHIJ?FHIHIJJJJIDHHIHHHHHHFFFFDDDEEDDD?BDDDDDDDDD@CDDDDDDDDD
@6HV
CTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGN
+
@@@DDD;DFFFHADHGBGGHIHHGGBFHIFH:?F?D>FHFEDGGEGGGHGGGGGEAA@CEBB>;;@CCCC<@>AC>ACBCCCCDDDECCAC>@:ACBCCB#
@6HW
TGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
@@@DD?DDDAF:DHG?C<ABH:CF;::@BB6<ACCCC388BBCC@A>CBCCCBB?5<?B@A>>@CCCCCC4:ACA4>>C@@@)5&+>A?CAA>::ACB
@6HX
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
@CCFFFFFHGHHGJGEEHIIJJIJJJJGGGGIIIJJJFFHGHJIGJJJIJJGHHFGHIIFHHHII=DHFHHFFFFCECEFDEDCCDD?BBD@CDDD:AC
@6HY
GCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCGATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGN
+
CCCFFFFFHFHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJIJJIJIJEGHJIIGHHHFFFFFFEEEEEDDDDDDCDDCDDDDDABD@DD9B#
@6HZ
CTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCN
+
CCCFFFFFHHHHGIJJJJJJJIJJJJIJJJJJIIJIIJDGIGIIJIJJJIJIJJJJJJJHHHFBFFEDEEDDDDDDDDDDCDDDEDDDCDDDDDDDEDDC#
@6I0
TTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGGGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGN
+
@<?DDDDBF>D?422222C@G9,<AFEEAE><FE9CDC)??@CGB9080?:?<=)=8).87=;).@77==AE>77>B>;>3333,;;5>;;(;5(,,55>#
@6I1
CTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGA
+
CCCFFFFFHHHHHJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJGIJJJ8B@EHIJHHEFFFEEEEEEDDDDDDEDDDDDDDDEDDDDDDDDDDDD
@6I2
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
@@?DAD>ACFHDHII9EBHHGECAE@CG?E><GHIBC000?(9=<BBFHAGCG9A>ECEC@C?;;@AAAB<@@AC5,:3>:55;>?>AAC@+(4(:@CCC#
@6I3
GGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCN
+
C@CFFFFFGGHGHIJJJJIIIJJJGJJJIIIJGGEGIJIGIGJJJIIJHHJIIHIJJIJJIJJHGI?EHBDCEEEEEECDDDDDDDDDDDBDDDCDDDDD#
@6I4
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
@@CFDFFFHHHHHJJJIGIJJIGGGIJGGHIJJJEHIIIFGIGGHGEEFGHJIJJJJIJH=AEHGFFFFFFEEEECACBBDDBCCCDDDD@ACCCCCDDD#
@6I5
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHHHFFF>BDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6I6
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJ@GIIJJJJJJJJJJJJHHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEEEDDDDDD#
@6I7
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCC
+
CCCFFFFFHHHHHHIIJJJJJJIJJJIHJJJJJJJJIIHIJJJJJJHGIJJJJJIJJJJJIIGIIJJJJEHHFFBCDDDDEDDDDDDDDDEDDDDDDDD
@6I8
GGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTN
+
??7DDADDBBD?A<CAB;F+C;FE>ECE9EBC99?9?DDI@B908?DD<8).88487;7@@@=;@CE:A=C815;;@@;3/',8'8>>>:ABA3::>AA(#
@6I9
CTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGN
+
CCCFFFFFHHHHHJJJJJJIIJJJJJJJJJJJJJJJJIJJJJJJGHJJJJJJJJJJJJIJJJJJJJHHHHHHHFDFFFEEEEEEDDDDDFDEDDDDEDDD#
@6IA
CTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTN
+
@C@BDDDDGHGGDAFHGHGIIIIIEGGGFHH>EGIICGHIGICHCGGDDDFDGEGC3EEGGGGFGGIIFCCGIIGIIAEEHHGDDEFFEEDECEC@C>@@#
@6IB
TTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGN
+
???D;DDDF>FAF@HEGG@9?BAEGHGIGCD?FDHIIIGFGI@F@GGGACCE8AB>D@@CC@>A=AA?CCC:@C9<ACCACACB?BBCCCCC:>@>B<))#
@6IC
CTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGT
+
CCCFFFFFHHGHHJJFGHJJJJHGIJIIIIJJJJJIIJJJGHIJIJJJJJJJJIJJIJIJJJHHHHHFFFFFEEEEDDDDDDDDDACDDDDDDDD?CC
@6ID
GGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCN
+
B@@DFFFFGHHHHJJJJJJJJJIGJJJJJJIJJJJJJJJJJJJJJJJJJIJIHHHHHHHFFFFFFDEEDDDDDDDDDDDBDDDDDDDDBDDDDDDDDDDD#
@6IE
GGAGCCACCTCGCTCTCCAGCGCTGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCN
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJIIJJIIJJJJIJJIJJJHHHFDDDDDDDDDDCDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDCBDDD#
@6IF
GGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJIJJJHJJJJIGIJJJJJJJIJJHHHGHHHFFFFFFFEDDDBBDDCDDDDDD#
@6IG
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CBCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIHIHHHHHFFFFFFFDDD9?BDBDDDEDD@CDDDDD#
@6IH
GTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTN
+
?@@DADAAFFBDAG?4CABD<IBFHE4:EDDGG9+<:E*1??D94*:1:?<BFH9?**?*9B49*00?)B4)=C<7@@7=C-7@G77?A77?=);@>C;;#
@6II
GTTGTAGAGACCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGN
+
@@@D??=DFFHHDHGIIGBHGGIGHIIFEIJGIGIGIGIIDFGBGBFHBFGHGGHG@FHDHH==8CHE@EDEHHGCECEEDD@C@@A@CCBB>>CC;@AC#
@6IJ
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
@@CFFFFFHHGGGJIHIJHHIIIJIIEIGGBGIJJJJGIHHHGIGIJJJJIIGIIIJIHGHHHHFFFEEEC@CDDDDD8=B>CCDDCCBD@DDCCCCDDD#
@6IK
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
CCCFFFFFHHHHHJFHGHHIIEHIJJIJJJJJJJIDHIJJJJJJFHI@EHHHFEFFFEEDCEEDDDDDDDDDDDDDDDDDDCDDDDEED@@CDDCDEDED#
@6IL
CCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGN
+
@@BFDFFF<DFHHGGIJBGIIJJJJIIHGGJG;CEFFFDFDEDDDBB?BBDDDDDDCDDDDDBDBBB>BBDDDDDDDDCCDD@BB<BDDDDDDDDDBDDD#
@6IM
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
;=@DD8ADHHDFFHHE?FBFEHGGGGGICE<F??FHHDD??@FADGHHGG?@8=CC<@FFG=C=DCEEHFFHHBBBCC6?CC;ACAACC>8>ACCCC
@6IN
GGAAGAGTATGCATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTC
+
@@@DADB2ACFFB@EE>DHHBHGIIEFGHGEBB??;;)1:BGAFHFG:F@GHII5C@.;BEH8)?@A366@BC@CC@>C@CCCB?CB<>@C@::ACC4>
@6IO
CGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTN
+
CC@FFFFFHGHHHIJJJEHFHHCHIJJJJIJJJJJJJIIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIHHHHHFFFFDEEEDDDDDDDDDDDDDDDDDD#
@6IP
CGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGN
+
CCCFFFFFHHHHHJJJJIJHIJJJJJJIJJJJJJJJJJJJJJJJHFDDDDDEEDDDDDDFDDDD@BDDDDDDDEDDEDCDDDDDDDDDDDDDDDDDDBBD#
@6IQ
GCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATN
+
CCCFFFFFHHHHHJJJJ<AAAFHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFFFFEEEEEDDDDDDDDDDDDDDDDDDDDEDDDDDD#
@6IR
TGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
CCCFFFFFHHHHHJJJJIHHHHIJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJIJJJJJJHHHHHGHHFFFFFEEEECEDDCDDD8>@DCCDDCDD?BD#
@6IS
CTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACTGAGCAGGAGTCTCAGACATGTCN
+
@@@FDDDDFFHGFHGGHIIIICFIIFDGGIEHIIIIIIIEEHGEHHGFFHHFFCDFFBCCCEDDDDDDDEDDDCDCDCCCCDCABB@39ACDDDDBCCDD#
@6IT
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTN
+
@??<DABDHHHHFGGHEDFCHHIHHICAFBGIIE;FHIEEGEECHGCHB:4=>CEEEC?@@CCC5>A8A,899CDDEC@>CCCC(9<@B9+>@C@A:4:>#
@6IU
GTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTTTTAGGCTTGGACAGATCAGGATCCACCCTGN
+
@@@DDDBB?CADFHGG<BHIIEG;CFFHEHA>GB:DCGHGE@?BHDCFDF?GED?B@DFC;CGEFCG=@ECEHEHADCBD>AACCCCAC>CCC9CAB?59#
@6IV
CAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGG
+
@??ADB;BFFFF8:E;F9<F?A?E>:<CF<2A??4EC?FF?DG<FG<0:F@?B??<9<?BFB===F<88@F@7C;7=C37?6A7?C?;B7??@(;@3((
@6IW
CCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTN
+
CCCFFBDFHHHHHJJJJJJJDD6<BDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDEDEDDDDEDEEDDDDEDEEDDDDDDD#
@6IX
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
C@CFFFFFHHHHHJJJJJJHHIJJIJJJJJJJJJGJJJJJIIJJIJGHIJIJJFGGIBHHHHHHHEFFFDDDDDDDDDDDDDDDDDDCDDDDDDADDDDD#
@6IY
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCFFFFFHFHHHJIJIJGIJIJJGEAHIJGI:@FEDFIGGGH=FGDGGGGGEECC>BEFFFACC@CCDDDDDBDCCDDDDCCEDDCCDDA>@CDDCCDC#
@6IZ
CTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJIIJJJJJJJJJJJJJJIJJIJJJJJJJJJJJIJJIJJIJJGGHHHFFFDDDD=CDDDDDDDDDDBDDDDDD#
@6J0
TGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTN
+
CCCFFFFFFFCFFGGIIGIJJJJJIIEGGCHIJIIHHIIJJJJJJIJIIIJJIIGHIJHIJHIJIJJJ=FEAGHJIGIIGEHHBBEDDDE@CDCCDDCDD#
@6J1
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
CCCFFFFFHHHDFHIHIJIIJJJJJJIJIIJJJJJJJJJJJGIJJJJJJJJJJJJJJJJJJIJIJJJIJJJGHHFFFFEEEEEDEEEEDDDDACDDDDDD#
@6J2
CCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTN
+
BC@DFFFFHGHHHJJIJJJJJIJJJJJJJHHGIJJJ@FHIJJJJJGGIJIIIJJJGGJIIIGGGIIIIHHHFHCDFFFFDEEDEEEDDCCCCCBDDDBDD#
@6J3
CCTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGN
+
@@@DDFFFHHGFHIIIIIGIDHBBDFHIIADHIGHIIBFHCHAAH@EHDBDEDCBD?DCBDDDDCD?AACBCD@ACDDD2<4@CDACCACCDDB>CBC@>#
@6J4
TTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCCTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJHHHHHFFFFFDDDCDDDDDDDDDCDDDDDDDDDDDDDD#
@6J5
GGCGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCC
+
BCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIJJIJJHHHFFFFFFEEEEEECDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDD
@6J6
GCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJIIIIIIJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJFFHJJIJJJJHEFHHFFFDDDDDEEEDCDDDCDE#
@6J7
GTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTN
+
B@@FFFDDHHHHHJJJJJJJJJIJJJJJIJJIJJJIJHJGHIIIJJJIJJJJJJJJIJJIJJJJJCHIGIFHGGGGIIJIJJGIHHGHFFFFBEECEEED#
@6J8
CTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCN
+
@@CFFDFDHHFHGGGJGICEHIHFIFJIJJIGIGHGGGDGFGIIIIDDHGIIICF@GHIIIIJEFAEEEDDDDDB?ABDDDDDD@@?CCDCCCC?<CDDC#
@6J9
CTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCN
+
?@;B?4BDD<DFDE:A9E@<?@HH@HB3E9AHEHBDFECFCFF*1BB3*?*?9BDAFEI:?FE8FC@FFIDFC>C>77??AEFEDD:7@;;ACCBAB:3;#
@6JA
CTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTN
+
@@@DDFFDFHDFHIHHIIEIIHIGHIIIJIFGGIJIGIGIIJIJGJJIIECEIIGGDDFGHGGIIIJJJIJEIJCHIIEEGHIJ;?EHGHGHDFFFFFFE#
@6JB
TGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGN
+
@CCFDDD1AFHFHEEEGBHGGIECDACGAAFGHCHEHIGHIIHIIIGH<BCGHIIGHGGGIGECHAHCED<ABCCACAC(;>C:@CDB9?BACCB<@?@>#
@6JC
GGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGGGCTGTGCGGGATAGGGGTTTTCCGGTTGGN
+
CCCFFFFFGHHHHJIGIJGGHIGHI;AEEHFCDFFFFCAB?@BCDDDBDABBDDDDCDD?;@BBDDDBCCDBDDD<>CB<B>BCCCBDBDDBCC@>9@BB#
@6JD
TGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATN
+
??@DD>DDFDFFHIGGIIIIIIEDEEGIGHHGEHIFGGIGDC?DBGHHECGIGIIGEDD05<A@A?BBCD<@??CCDAB?C@@CCDDCCDCCCCD<@BDB#
@6JE
AACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTN
+
CCCFFFFFHHGGHJJIIJJJIIJHHIJJJJIJJJIJJJJJJJGIJJIJJJJIIJJJJIGICFCHIJJJJJJHHFHHGFFFFFFDCEFEEEDDDDDDDDDA#
@6JF
AGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTN
+
BC@FFFFFHHHHHIJJHGIJIJIJJGIIJIJIJJJJJGIJBFGIJJGJJJJJJJJFHICHIJIJGIIIHGEHFBAC6>CBDBDDDBDDDDDD><@?BCA>#
@6JG
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJIIJJJHJJJHIJJJGIJJJJIJJJJJHHHHHFFFFEEEEEDDD@CDDDDDDDDDBDAACCCC
@6JH
GCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJCHHIJIJJJJJEHIJIJJIJJJJGIJIJJJJJJIJJJHHHHHHFFFFDCCEEDDDCEDDDDDDDBDDDDD#
@6JI
CTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCN
+
CCCFFFFFHFFHDGGIIJJJIIJJJJIJJJIJGIIIIIJJJIIJIIIJGIIIJIIJJIJICHHHHFEFEFCCCEDEEDECDDEC;@CDCDDBDBDDDDAC#
@6JJ
GTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
?==DDBDDFHHFDBGHIB@EHEDEHIIGHI<C@DGBDHIB>FGGEBHEHCCF@CBF@FF;F;>EGGEAEHA@B?>BEEEECCC;@>@B@6'8555@94>
@6JK
CTCATCTGTATGACCCTGTACTTCTATTTGGAAGCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJHIJIJJIJJHHHHHHFFFFFEEEEEEEDDDD#
@6JL
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJ@FIGIIJJHHHFFFDEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6JM
TTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTA
+
@CCFFDFFDHHGAGIEGIGCHHGHFFBEHEIIGIJJJICBBAGIJJIGIIIJIGIAEEEHGGIJJA>DHICHEEH9BBACE@CA?A->C@@CC>CCCCD
@6JN
GTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTG
+
C@@FFFFFHHHHHJIJJGHEGIDIIIJJJJIIJJJJJJIGJIJJJHGJJJJJJJIIIIJJJJIJJJJJJJIJIIJIHHEHHHGFEFFFEEEE
@6JO
GCCATCCACAAAATAGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACTGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJIJJJJGIHHHHGHHFFFFDEEEEDDDDDEEDDDDDED
@6JP
CAGAGAGGCCTGGGCGGCTGGCCAGGCAGGCAGCCTTCCCGAAGGCGGGACTAGGCGTGTGCTGCTGGACATGACTAATCCACCCCGGGGGACAGGCCC
+
CCCFFFFFHHHHGJJJJJJJIIJJJJJJJJJJJJHHHHHFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@6JQ
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJ@FHFGIJJIJIJIIJJJJJHFHHHHFFFFDDDDDDDDDDDDDDDDDDDDDCDEEEEDDDDDD
@6JR
GGGGCCCCAGGGCGCCGGCCCAGCATGGGCAGTTGCTCATTGTTGGAGATAAGGTCGCGCTGGTCATCCATGACTGGCTTCTGATCTTCCCGACAGCTCCN
+
@@@FFA?ABHDHFDGDHDGEDEHGIIFHIEFHEEIGGEEEHEHHFFEFD@CACA55;?BBDBBCCDDDDDD>>@3>ABDDC>CDD:ACDCCD9BB7?(>C#
@6JS
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
@@CFFFDDFHHF>EGGCAB=<C?EEHI@E?FGFHGGD?GF@FBDDFIGGIIGHI<F<8CA@FEADGGEHGBEEB>;;>;>>;A??AA@3;53A@A@(:@>#
@6JT
CTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTN
+
@@@DDD?DH?FHHFGFGECCGH>H<BHDHGIGIGIDHGHGAF<FBCD=@DGHGIIEHGEGEEHEH?@CCDE@@CC<ACBBCCC5>C;>ACC??CCCCCCD#
@6JU
CACGGCACAGCCTAAGATGAGCGGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAAAGTCATTAATTN
+
@@@ADDADH>D;CFGEBG>HEHIA8D?=DBFE?B9BFE9?CH9=3==C;FAC@DDHGFE>EE:;?BCCAC;@ACC<>CA@CCB?BB(:9A>:4:ACCC>A#
@6JV
GAAGGATTCTGATCATAACTCTGAGCCATGGGGGTACCTCTGTCATCTCCCCACATGGCTCCTGAAGAGCCTTCCCAGGGCACTGCTAAAGGCGCCTTCCN
+
@;?;D:=DFCF>DBFFFBFAH<IH<FFAFFIIIE0:?B<DDDFFD<D?=FEEEFFIIIFEF;7AFD@B;>ACCBA6>>=;?<@9A@B<AB:>@&0599>?#
@6JW
ATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGN
+
@@@FFFFEHHFDFIGEFHEDEECDEGGEGIGHEHGEGHDCGE?DCDDHCD?DGGIGGHIIIIIEEHI@GHIIG@=CA??EHHHHBCDFECCCEAACA@>3#
@6JX
AAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGA
+
@@@FFFFBFHGHFJGAFGIIJJGHEHIJIHIIIGIIHHGCAECFBDDEEEDD?BDDCDDCDDCDCC5:>>CCDCD?B9?B@?BDD<>B8A<<ACCDDB
@6JY
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATN
+
@@<DDBADFFFDFIIGIIG?CFHEEGBGGEGEHEHDGAAFFHEGGGGEIEGEGHI)<A4@E5?AAHE>ADBBD;@C6=@';>CDCCCCACC??A5>ACC>#
@6JZ
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
@C@FFDDFHDHFHGGIGIJJIIJIJJEBHIIJGIJIJIIJJJJJHHFGIIJJJGJJAGEHHHHFDCFF>@CAEC@CDCCAC<CCCDDDD5@ADDDCDDD
@6K0
CGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTN
+
B@BFDFFFHHHHHJJJJJJAFHFHHJJJJIJJJJJJJJJJJJJJIJJJJIJJIJJJIJJJJJJJJJJJHHHHHHFFFFDEEEDDDCDDDDDABDDDDDDD#
@6K1
GTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTN
+
@@@FFEFFHHHFHIIJJIJJJIJDHIIJGIIJJJJIIJDDGIFGGIJIIIICHIIJJIJIIIJIIIIIJJJJIIIIIJIIJEHHHGHHHFFFDDFFEEEC#
@6K2
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCN
+
@@<DABD;FBDDAB9EB?C;E:A4B<CHFAC?3))1?DFADBFFIIIIAGE<FEDFG*BF>C<CFF@FCEFI<9?2?C;BD;@@B>@B?'(,8?,98@4:#
@6K3
GCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
@@@FDDDAF@FHHFHIIIIHHIIGGGGIGGIGFHGIGHIIGGIIIIIIIGHGIHHIIIIIHIIEHEDFFFEDAEEEDDDDDDDDDDDBCCCD@C49A4>B#
@6K4
TTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGN
+
@@@DD?DDAC2A?A+C?1C<?CC?FF<?F<:BFFG???BD<BD??=F=BCF;@FFE=@===BB=89B;;2658(,;A:AB>(;@B9@>(3++:AB<55+4#
@6K5
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@?@FD?DDDHHHHGHIIIGIIIICGAFHGIIIG?FHICGIHG@FHH@E;=EECHEAB<>A>>6>CC;>5@CB:@?<CCCCCCC<>CB>ACC>ABA>9?C
@6K6
GAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTN
+
CCCFFFFFHHHGHJIJIIJJGGIIJIJIJIIJJIJJIJIIJJIJGGIJIHIIJJJJJJHHHHFDDEEFDDDDCDDDDDDDDDDDDCFDEDDDDDDDDDDD#
@6K7
GTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGGGATGCTCGAATN
+
@@CFFEFFHHGGHHGEGHIEHAEFHEGGIJIHIIJJHIIC?FFFHIFCHH@FDGIIIJCBFDHI@FGAHCCE?EFBB@CDDBBB@AC?'89>BACDD@?C#
@6K8
CCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIHHIHIJJIGIIIIGHGIIJIJJJJJJHHGHFFDDEEEDDDDCDCCDCBDDCDEEEDDDDDDDDDDDDDDD#
@6K9
TCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTTTTTCTGGGGACAGCAGATCTGCCAGAAATTGAGGGTGAATGACAGCCTCCACCTTGGAGACA
+
<@@DDABDFB<CF?GDB+3;A@B@F;+2:11@GFG??GB??D499?1?B?(B=C887)..=7(7)=@=CF>5,5?CD;6>;.==?;;9?<<>>?:<:??
@6KA
TGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTN
+
B@CFFFFFHHHHGJJFHHIJJJJJJJJJJJJJJIJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJIJJJJJIJJJHHHHHHFFFFFFEFEEDEDDDDDDDD#
@6KB
CGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGN
+
@@@DD@DDFBB=F2AGGGEHICFF?GEHCGHIGGHIGGFGFHC>FIBH@=E;=?>@DEA@ACCCCB?@CBCDCCCCCB??>>BB59BBCCC@CDDCECCB#
@6KC
GCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTN
+
CCCFFFFFHHGFHIGIJIJJJJIJHJGIIGJJIIJGIJJJJIGHIJJJJIJIJGIJIIJGGHIGEHHIGHHHHFFFF@DF@CCECEEDDEDEDDCDDCDC#
@6KD
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFDFHHHHHIIJIJJJJJJGHIJHIJJ1?GHGIIJIJJDHHIJIJJJJJJJIJJJJJHHHBEFFEEEDEEDCCDDDDDDDDDDDDDDDEDEEEDDD#
@6KE
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
BBBFFFFFFHHHHIIHIIIIJJJJHIJJJJJJJIJJJGHIJJGIIJFHIJJHHJIJFIJJJJJHHHHHFFFFEEDDDBDDCEDDDDDDDDDBD@CCDCC
@6KF
CCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTN
+
??;?B:=<<<DFAG?D8FBGE<CEAFGEGGCA:::BGIIIEEFFEAFF@@7;B;A6;=;?B9@:ABBADABB?BB-9<5:@@:A>B<@B8?9:4<4++(+#
@6KG
CCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTGCTCTCAGGCTGGA
+
@@@DDDBDHHAFDDGIBABI@E;FEGHGIIGCB@?1CFHGEGEGGIEGDEEGC/B@FFG;CCFDH>GGEHHCC(;?DFC@CCC9?A?B
@6KH
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@CCFFFFFHHHHHIIHGGGHHHIGGIEHIJJJIIJGEGCEGIIGIIDFGIIEHIGFHIGIJJJ;BHE>@CEEEDC@BBDDBDDDDDCCBDC?CCDDCDDD#
@6KI
GCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCN
+
@@@DADDDBHFACGGBBGE@FBHIIIHIIIIBGCGE>GII>F9CFHFGGG@=DBFHGIGIICGA=FC@;@C>FCHGGFE;=;7?@CC?A8;?CD>>:5:?#
@6KJ
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJIJIHJIJJJHGJGIIFGIJJJJIGCHIGJJJIIIJIJIJJIIJGIGIJGGIHIHHFHHFFFEFFDDDD;@BB8@CCDDD:ABD?BD#
@6KK
GCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGT
+
@C@DDDDFHHHHGJIJGGJJJJJJJACDHGIJIGFFFDGHI@GGIIIJIIJHIJIGGAHGID;EGGGFHCHEHFEBCD@AC?A?AB@CDDDC
@6KL
GTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATN
+
@@CFFADDFFGHGGIGHGHGEGHHIIC6FGHGGGGGGG:FGBBE88BCDACCCCA@B@CCDDD@BDD8;9CCCDDDCDDDDDDDC?BBB9>@BBB@DC@@#
@6KM
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGN
+
CCCFFFFFGHHGHJJIGIJIHHIJIJJJJJJJJJJJJJJIJJJJIJJJJJJIJFGIJJIGHHIIFGIIJCE?EFEEFFFFFFDEEECCCCEDDDCDBDCD#
@6KN
CCCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTN
+
@@@FDDADDHFDFFHHGIJHDHEEFHGEGGHIIJG@FHGHGIGGFDBFDFIBBGIFBFHIIEBCGHGHAFGIEC@DECEAACE;;B@CF@AC;AC@ACC;#
@6KO
CATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGN
+
C@CFFFFFHHDFHIIIJJJGGEHIJIIJJGGEHJJIJIIJIJJJGGJJIGHIJJJJJIHGHHFFFFFFDD=@D=CCCDCCDDBDDDDCDDDDDCCCDDDD#
@6KP
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
@@@DFDFFHHHHHJDIIJIJIGBHFHFH<GGIIGIIJJIIGIIGIEGGIIHIGIIGGHIEIIJIEGHEDEDEEEEC@ACCCDDDDDBBDCDDDDBCDDBD#
@6KQ
AATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATC
+
CCCFFFFFFHGHHIIJJIHIFIGGHIIHIIIGIIIIJJJJJIEHHGD@FGIGIHGIJIIIIIIJCFGIEGIIIHIJGCHDF@>?CEE@CDCCDFEDCCA
@6KR
GACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGC
+
@@@DDBDDDHHFFFHGGIEABFGHBHGIIGB@FCFDFHEGBDGEH?B@DAGGIEEDHIGGIIGI@BFH@=F@HIIGGEAEE?ACCH@?CDEECCCC@C@
@6KS
GCCTGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
CCCFFFFFHHGHHJIIGIIIIIGIJJJIJJJIIIIIIHGIIJJJJJGHIIIJIJJIHHJGGIIJ;EHFBDDEEEE>CDDDDDDDDDDDDBDDDDCCCDDD#
@6KT
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTN
+
@@@BDEFFHGHHHIIHGIIGGIHHDGIHI@@FFHGHIIFHIIIIIIIIIIEHIIIIICIIIHHHDHFEDFD>@DCEDDCDB<ABDCCCCDCC>CCACC?C#
@6KU
GTGCGTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATN
+
@?@FDFDFHFFHHGIJJGIIIIJJJIJJIIIGIIGIIJHEGGIJJGIIIHGHIJJIIGIHIGIJIJGGIGEGCGHJFEEEHHHFFD>DEECCCCEDCCDC#
@6KV
AATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGN
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJHHHHFFFFFFDD=@DBDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6KW
GTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJIJJJHIJJJ?FGIJJJJJIIJJJHHHHHFFFFFEEEEEEDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6KX
GTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTTCAGCA
+
CCCFFFFFHHHHHJFHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJIIJHHHHHHFFFFDDDDDDDD
@6KY
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
CCCFFFFDHFGHHJJIJJJJJJJJJJJJJHGIJJIJGIHGIGHIIJIIIIIIJBFHJGHJJ5@EFCHFHDFF?BCEEEDDDDDDDDDDDDDDDD9@BDDD#
@6KZ
GCCTAAGTAAAAAGTAATCCCCAAATCCCTCTGCCCATTCACCCATTAGCTTCCTGTTACACAGAATAAATGTTTAGATTACTCCCACCCACCCTCAAATN
+
@@@FDDEDHHFFFIFHIIJGHIIGCHIIIIJJJIJJGHJIIIIJJJJJIGGIHIIIIEEGHGHGIIJJEGGIGEGDHHGHFHFFFFFEDDDBB?BBBCCD#
@6L0
AGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTN
+
@BBFFFFFHHHHHJJIIJIJJJIJJIJJIJIJIJJJJJJJJJJIIJJJJJFIJIJFHIHIJJIIJEHGHFHHHHFFFFDDEEDDDEEDDDDDDD8>BCDC#
@6L1
ACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGN
+
BBCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJGHIJJJJJJJIJJJJJHHHHHHHHFFFFFFEEEEEEDDDCD#
@6L2
GCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTN
+
@@CDFFDDDHDFAHFGBF@HDDHHHIHIEGGIIIIIIIIIIIHGIGIIIGHIIGDHHGHGFFFFD?@CDCA?@D?=<ACCCAACD@C@?@?B?CCDC@DD#
@6L3
GGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJFGIIJJJJJJJJJJJJHFFFFEEDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDE#
@6L4
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
@@CFFFFFHGHHGJJIIGJJIJIIIJJJJJJIJJFGGJJJIJJJGIIFDHIJIJHHGHGIJHIJIIHHHFFFFFFEEDEECDD;@BDDCDDD>@@CDCDD#
@6L5
CTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
@@@FFFDDDFDDHGHGGHIIJGIGIIJFEHIJHFFB<DGFHFIIIIGHIIJFDHHI=BFHCGGJ-7?C=@BF@ED=A>CDCCCDDDDB?BDDDDBDDB
@6L6
ATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGN
+
CCCFFF;DHHHHHJHIJJJJJJJJJHGIJJJJJJJDGHGJJJJJJJJJJJIJJJIJJJJJJIJJJJJJJJHHHHHHFFFFFFEDDDDDDDDDDDDDDDDD#
@6L7
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
@@@ADDDDH?;FFAHHIE4FCEGG?EECGGIEDHGHGIIIIIHIIIIIIGFGIIFHFECDDEECCCCC@AC?>>ACDECCCCCCC@:??BCCBCC@?CCC#
@6L8
CTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCN
+
CCCDDEDFGHGHGIJGHIIIGHJJIIIGGGEGIHIEHIGHDGBFHIEGIGGIIIIIJIHIIIHEHFFFFEEDBEDDDDDECDCDCBDDD<@DDDDDCACD#
@6L9
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJHIJJJJJJJIIJJJIJIIJJJJJJJJJJJJJJJJJHEFFFEEEEEAEDDDCDDDDDDDDDDDDDDDDDD#
@6LA
GTCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCN
+
@@@DFFDDB=AFFEHA@EHGIFFDFHGEG@FG<FDBEHIEIEE@6EEHD;BDEEC=9@AA>A>5;:::@ACDCC=,8<<ABBB9?CCC>CC@:9ACA>>A#
@6LB
GTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCN
+
?@@DFFFFDHHHGHGIIHIJGHGGGJIGIJJGGGIIJJJIJJJJGIJJJIJJJJJ>EHHHHDBD>CCEDCEEDDDD;@CDDDCDDDDDDDD4@CBDDDBD#
@6LC
GTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCN
+
@@@DDDDDFFBHC?EFG:FFHB@ECBE?C:DFHG@DHAEHDFHGGGFFGGG<?B?=B@CCCCC8??=>BB3598@>BC?@CC4:B>4:@:>38@>CC?3<#
@6LD
CCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
CCCFFFFFHHHHHJJJJJIIHIJJJJJJJIJIIIJJJJJJJJJIIIJJJGIIJJHBCDDDDDDDDDDDDDDDDDDDDDDDEEDDDDDDDDDDDDEDDD
@6LE
CAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTN
+
CCCFFDDBFFHDHDGHHEHFECBFGBFHEHGHA@GFB3?C@:?BD<D@9FH@;-.===@@=CE;??EBF3=?>B>@>>88:A:::5::<@B>5?12?AD>#
@6LF
GGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGN
+
@@@FFFFFHHHHHJA<<<FFHIIJJJIJJJIJIJIIIJJJJJJJJIJJJJJIIIIIHGFHHHHFFFFFFCDD@DDDCCDCDDDDDCDDDDEDDDDDDDDD#
@6LG
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@<@DDDDDFF6CDDFFII><<F12::0??G*?F60)00*/.>BFI878C7=C85-(;);@;@D;>AC>ABBBAB>;,>DB:3;3:599B@BB9(2+44>
@6LH
GGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTN
+
CCCFFFFFHHHHGJIJJJIIJDDDDDDDDDD@CDEEEEEDDDDCDDDDDDBDDDDDDEDDDDDDCDDDDEDDDDDDBBDCDDDCDDDDDDDDCC>CDCCC#
@6LI
CCTTCATCCATGGGTCCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJJJJIJJJJJJJJHHBFDEEEEDDDDDDDDDDDDCDDDDDDDDDDDDDDDCD#
@6LJ
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCN
+
CCCFFFFFHGHGHJGIIIJJIJJJIIJIJJJJIJJJJIJIJJJIFIIGJJJJIIJGIJJJIIGHEHIJJIEEHHHHEDFFFDEFEEEEDBD2=BDDDCDC#
@6LK
CTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGN
+
??8?ADDBC?FHFGBHHBHIDG@FE<:CDGIE@GH@?EHA<HHII@FHAGHGIGDGHGEGGHCFFE@@@@=EG@7?HEHD<<6=C>C5;BCCCCA:3;?0#
@6LL
CAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGN
+
@@@DFBEDFHHGHFHIJEHGIECGIICHDFGGGIGIIGIJIGHGIAGIGBHHHHH?BDACEEEDB?CCCCCDB9<ACCACCCDCDC?BB9<B@@<:>D:A#
@6LM
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGN
+
BBCFDFFFHHHHHJJJJJGHIJJJGIJJJJJJJJJJJJJJJJJFHGHIIIJJJJJHIJJJJJFIFHJIIHHHHFFFFFDDDDDDD?BBDDD>CCDDDDDD#
@6LN
GCCGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACG
+
CCCFFFFFHHHHHJJIJJJJ:CHHEIIJIGGHIIJIJJIJIIIIIGHGGHIGCHHIJJJJJIEHCEGIGGGIIGHIEECE>CHFFFDFFFEEDED
@6LO
CATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCN
+
CCCFDFFFHHHHGJJJJIIIJIIJJIJGGIJJJJJIJJIJJIJJIIIIHJJIJJIIJJJJJJJJJHHHGHFFFDEDEED@CCEDDDDEDECEDDCDDDDD#
@6LP
GCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCN
+
@@@FBEDFHFHHGIIFDDDDDDCDCD@CDDEDEEDDDBCCDDBDDDDDDDDDDDDCACDCDCCCDCDDDDD9@DCCDDAC?CCC@CB@AACC@>CC3@CD#
@6LQ
GTGGGGACCAGTTGAGCAACTGGTGGTGGAGGCTGAGGCGGAAGGCCTGGAGGACCCTCCTGGCTGACACCAACAGCCTTAGAGGGCAGAATGGTCTTC
+
CCCFFFFFHHGHHGJJFJIJIJJCFG?DFHIIIJJJJIJJIIHEDFFFDDDEDBDDDCBDDCCBCDDDDDDDDDDBDDDCDCDDDDDBBBDDDDACDDD
@6LR
CACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTN
+
CCCFFFFFHGHGHFGII@FGAHIJJJJJJGIJJIGGIJJIJEHGGGIHIJJJIIGHEFHFDFFFFEEEEEDDECDDDCDCCDDDDDCCDAACDCDDDCDD#
@6LS
CTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGT
+
CCCFFFFFHHHHHJJJJIJJJJJJJJIJJJJJJIJJJJJJJJJJJIIGIIJJJJJIIJJJJJJJJJJJJJJIJHHHHHFFFFFFEEEEEEDDDDADEF
@6LT
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJHIJJJJHIJHIJJJJJJJJJJCHIIJHHHHHHFFFFFFEDDEDDDDDEDDDDDDDEEDDDDDDCDDD#
@6LU
CTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGN
+
CCCFFFFFHHHHHJJHIIIJJJJJJJJJJJJJJJJJJJJBFIHICHIJJJJJJHHHHHFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDEDDDDDDDDEDD#
@6LV
GCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGGGGGN
+
???AA=8AA2A?:22A?A<::<AFFI<???18?D:DD9D@@9D@?D9*9BBC>8;A@@2.))777A7..;7?>@@A3.665;;>5((5,88=A79>&09&#
@6LW
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGN
+
@C@FFDFFHHHHGJJIJGIIJJJJIIGHIIJJJJJJJJJJJJJIIGIJIJIJGIIIIIJGIIIIJIHHHHHFFFFFFFDEEEEEEEDDDDD@CCDEDDDD#
@6LX
GGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTN
+
B@@ABDDDHHFFFIEGHGHIIIIHGHDIIGGHIJJI@FGIIIIJJIIHHGGHIIIGIFHIIHHHHGHFFFFFFFEEDCDEDDDCDDCCDDDBBCDDCDDD#
@6LY
CAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATCCTCTTCCTCTGCTTCCTTTTTCTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTT
+
CCCFFFFFHGHHHJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIIJJJJJIIJJJIIIJJHHEEHFFFFFFEEDCECDDDDD
@6LZ
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHHHHHJJJHJJJJJJJJIJIHIJJJJJJJJJJJGGIJJJJJIJJJJJJJJJJJJJJJJJHHHDFDFFEEEEEDDDDDDD9CCDCDDD2?@D
@6M0
GTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTN
+
BBBFDFFFHHHHHGHJJIJJJJJJJJJJJJJJJJIIJJJJJJJIJJHGIJIJJJJJJHHHHHFFDFFFEEEEEDDDDDD<CCDDDDDDDDDDDD@CDDDC#
@6M1
CTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGGGGTAACTAGTGGG
+
?<@A?DDADADBDCAE@EE@EF>FGDAHB>GG>F?<DAG@CHE@A@>A@<DAB@CCE>D=@>AE@@C6=AC@:77;@;@>ACBB'5<>-5>:34>(4<?
@6M2
GGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTN
+
@@?DFFDEHHDDFIHIIJFIIJEGHGDGHGCCHGIEGIIJIIJDCHEHIJGDGGGDDBB<CCDDCCDCEDDDEDCDDCCCBDDDD@DDCDDEDDDCCCCC#
@6M3
GTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGCATCCN
+
:?8D:B33<?:AFFEBA<CIH9)3328CC;B@D3?GFFA4C9D4DF@994?BGF9D*7B)8@=CC==FE7==CFCEB@;B3?3;66;;(;(;;?5(((5>#
@6M4
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
BCCFFFFFHHHGGJJJJJJJJJJJJJJJJJIJHIIJJIJJJIIJJIJJJJJIIJIJJIJIIGGHHHFFFFFFDDEEEDDCDDDDBDBDCCCDDDDCDC
@6M5
CGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTN
+
BCBFFFFFHHHHHJJJJHICHHHGHIJGIIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJHHHHHFFFFDEEEDDDDDDDDDBDDDDDDDD#
@6M6
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFFFFHHH<DFDGHIJIJIJHHIJEGHJJIHIIJJIJJIGGHGHIJJIIIIIIAEHEFEHCEDFC>@A@ECACC>ACCCCDDDDD@5>CCACCCCC
@6M7
CCTGATCATAACTCTGAGCCATGGGGGTACCTCTGTCATCTCCCCACATGGCTCCTGAAGAGCCTTCCCAGGGCACTGCTAAAGGCTCCTTCCCTTGAGGN
+
@@CFFFFFGHGGHJIHJEEIEEGICCEGFDGGIJGJIEGGIIHIIJJIGEIGGGIGJJJAE6?EBEFFFDCAABDD?;AACDD>:?@ABDDDDDDDDCC?#
@6M8
GTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGN
+
@CCFFFFFHHHHHJJGGGIJJIJJJJJJJJIJJJJJJJJJJJJJGHDGIEHIFHGGHIHJJ=FHIDHIG;CBFBFFDEED;=CDDCCDDDDDDCDDDDDD#
@6M9
AGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGG
+
@@@FF<DDHHDAFGFGGBCGGHCHEHCFEHGDFDGIGCGIIGIHIJIJJIIIJGGIFIGECADBC>BB?C?AD??ABDDB<ACDCCC
@6MA
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHHHJJJJJJJHIJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJFHJHIIHHHHFFCEFFEEEEEABD>CDDEEDDDDDDDDDCDDD
@6MB
CGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTT
+
CCCFFFEDFHHCFCFHIEFHGDHIGIHJJIFGGIIJIGGGFIIGIIIIJJJJIHHGHGIIJJIIGEII@CEHEGGHHHHHFFC@CDD@AEEEDDDDDD
@6MC
CACACACAGCCGGAGGTCATACTGCATCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCN
+
@@@D?AAD?:A80<E@:?EGGB?:?D??B0:BGDD9DFII>89C>BFCFA@CF@@@7=DCEAABDDC;;=;;A?<=BBBB>>BBB3>:+49@BBA@><?B#
@6MD
GTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTN
+
@@@DDDDDHHHDDBEDDHE+?@CAEFGIGIEGI>GFHGIIGCFEH0BD8BFG@7@GIIB8??@CEECCCCCCAA@AA>AC;=BBB8A@ADEC@C><50<@#
@6ME
CAGACATCTGGCGTTGGAACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGN
+
@@@DD?DDDFFFFFGFF+<9<CE@B?BGDG?FF?F9FFAFBFFFBBFFFBBEFFF(;BC@BC@=B@?@>AA@@<@B>A:@AB?AB9@BB<BBBBBB@>@A#
@6MF
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
CCCFFFDDFHHHHJFIJJJJIJJJJIJJJIJJJJJJIJJJJIJJIJJJJJJJJJIJJJIJHHFHEFFFFFFEDDDDEECCDDDDDDDDDDCBDDDDDD39#
@6MG
CCTCAACAGAACCAGAAGGACTTGAGTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCTGCATCTTCCTCCTCTTCCAAGGCCATGAGTCGCTTCTGN
+
@@?BDDFDFHDHHGFEHICBGD@CFFAEGDFA?9:DGHHEFHDHDGBFHIDFAH?C:=BDBFCCAACACAC@CCDC>:>ACD@<9<AC>::4:>>9A5>@#
@6MH
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
C@CFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJHIIJIHIJJFHIJJIIIJJJJJJJIJHHHHHFFFFEEEEEDDDDEDDDDDDDDDDDACCDDC
@6MI
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
CCCFFFFEHHHHGJJJJJJJJJJJJJJJJIJJJJJJIIHIJJJJIIJJIJJJJBFHIGHJJ;EHHFHHHFFF;ACEEEDDDDDDDDDCDDDDDD09?CDD#
@6MJ
CTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTAAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATG
+
@@@DDAADDFFFFBDH>?IDHHIABHGID9FHI@HHGIB?CFGGFHIIEBFIII>?F*0?GFGHIGGEFDGHI<=CCCFCAGCHGG=CA=?EEE)7;>?
@6MK
GGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTN
+
@C@FFFFFHGHCDFHDHGI3<FHDEFHCGG?CGGIGIIGIIIFIGIIGIIGIFEHIGIIIHHF=?DEFDFDCDBCDDDD>>A@CDDDDDDCDDDCCDDDD#
@6ML
CCCCACACAGAGTCTTTGGATTTGGACTTAATGGAGTCTAAGAAAATCAATCTTTCTTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGN
+
?@@A?D?A:A?CFHDHBFEHIIIII>EC?C9CC4*?:1?DDHBGDBGHIGG@BBFHDGIIGG=CD=@;;CCHHAA?E7A?BBD;CE@>>>;(6;CDACC?#
@6MM
CTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTN
+
@CCDFEFFHHHCFIFHHGIHJIJJJJHIJJJJGJIIIFHICGDGHIIFHIIJIIJJJJJJIJJJIJGHGIJJJJGGIFHHHHHGFFFDDFEDCCCCDCDD#
@6MN
AGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCATCGAATTTTTCTGGGACAACACAGGTGTCATN
+
CCCFFFFFFHHHHJJJJJJJJJJJFHIGIIJJHIIJJJJGIJJJIJHIJIIJIJHGHHGHFFFFFFEDEEEEDDDDDDDCDCCCDDBDDDBDDD:ACDCD#
@6MO
CTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTN
+
8?@DDDD?CFFF8CCGIBFB<FDFEB,<+AFDFAGDAFG?CFDGF??F>9?F???/0?BB<BCCFGE-5;CEBEFE>AEB?DBB?C??BAB@@BAAB:'3#
@6MP
ATCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGA
+
@C@FDDABCFFDBGGGEHIIEDEEFFHHGC>?EGGIIFIIJDHIJIJJIIIJJIGGIJJGIICHIJJ@GH@DGGHEEA?;C>A@CEFEBEEECAA5@C
@6MQ
TGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJHIJJJJIJJJIJJGGIJJJJJJJJJJJJJJHHHHFFFFEEEFEEEDDDDBDDDDCCDD>CC
@6MR
GCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGN
+
?@@F?;ADDFHHDGEGAEC@>EGIHGIIBEHHG@GG?DD?GDHEIIIHC>BFBFGHHHE;FEAHGH@@EGE;=C?AH=773798>@:@;:@>>CC>CCDB#
@6MS
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTN
+
@@@AD=BDFBFBCECCBD@F<,:AC@3AF@FEII?DDFF==)..;FAC8=4=B6;;6659;;>:,,,5<5899::@AABA4@8<+3)&0<2::@AA>>(:#
@6MT
AGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCN
+
<1?DDDB?FAHF>H@F<FGG@DEHGIFGGFFEGGIEG@FHHGIFBEGFA=A8=;BEDDC<8;:=08@;B;BB-5CA>CBB3<@@@?B889ACCCCC9C:@#
@6MU
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAGCTCTGN
+
@@@DDDDDHHBCCEFGGCFF<E@GHCCA?EDF@GGGGHGFHGCEHBBFGEHCHGDDGGIHFFHEBBDCC;@>>CCB@;?B9ACCACCBBBBB@>>AC:>:#
@6MV
GGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAA
+
@@@=DDFDFDADFFGDDFGIGFGGDFFGH@E@GDGHHIGGIEHAHEH@FDEEHDECEHHEFCFD?;9>?==<A9A?<<A>8ADB<AA>AACB9A<A@CC
@6MW
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@@@DDDDDFH8ADFB<CB@A<CDGG<F<:?C?BBGHIBGGC3BDG969*99?DGGBFE@<4C8;A:8='.6;>3;(;55<B@8(58:(4?B333(((43:#
@6MX
CCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAG
+
@@@DD:BDBBHHHBIDEF>EAE?CCEHIII@GGHE<CDB?BBFG<B@BECBBFFFGII@CCF;F@@;CDGGE<EEBDCC;CACDCCC=@9<099@CC
@6MY
CTCAGCCTCAAACTCCATGAACCTTTCTGCCATCTCATAAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCN
+
@@@DDD>DFDBD?@DAFGHCHCEAEEFCEHGCCDCHEEEIIG@?<<DCH>AG?DHGGG=@GF>FH)=(;AAEHHEDDEECCCCCCCBBBC9ACBCBCCCC#
@6MZ
GACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAAAATGGACTTAAGCTATAGCN
+
CCCFFFFFHHHHHIIJJJJJIJJJJJJJJJHHHHFFDFFEEEEEEFEDDDDEDDDDDDDDDDDDCDDDDDDDCDDDDDDDDDDCDDDDDDDDDDDDDEED#
@6N0
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
CCCFFFFFGHHFFIJIIJIJJJJJIIIIIIIJJIIJJIJIJFHJJJIJIIJJIIIIJIIJJJJJJIJJJJIHHGFFFFFEDEEDEEEEDDDDACDDDCBD#
@6N1
CGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJIIIJJJHHFFFFFFEEEEEEDDDDDEEDDEEDC#
@6N2
CTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGN
+
CCCFFFFFHHHHHJJCGHIJJJJJJJJJJJJJJIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFFFEDCEEEEDDD#
@6N3
GTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGN
+
?@@7=DDDFDDBFIII>BEFB:F?CADBH4<E9?+1CEGF?9CDF>FFFFFIC?FFEE?D<@F8*.)==)7)5)56)7@A:EAEFD37?@@;;>@B(6((#
@6N4
CTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCN
+
CCCFFFFFHHHHFIJJJGIIJIIJIIJJIJIJIJJJJJJJJJJJIIIJIJJIJJIGIJGCGGIIIJIJIIJJJJJJIJJJJIIJJJJHHHHFFFEFDDED#
@6N5
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCFFFFFHHHHHJJIJJJJJJJJJHHIJJJICFIIGHHJIIJCGIJJJIJJHHHHHFFFFFEEEEEDDDDDDDDDDDDDDDDEDDDDDDDDDDDDEDDD#
@6N6
AGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATN
+
@@CDDDDDDFHHFFHGGEHHIJIJJJJIHIHIGGJJIIIDHHJIIICGBHHBFHGGJJICFGGHIIJIIGH;?BF>@CDEDD;?CDD:ACCDDDBCDBDD#
@6N7
CCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGCAGGCAGGCGGATCGAGTCTTCCTCCATCCTGAGCGCTCGAGGCACTGGAACATGAAGTGGCGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJCGGIJIJJJJJJIJHFDDDDDCDDEDDCDDDDDDDDDDDDDBBD<BDB?BDDDDDDDDDDDDCCDBBB#
@6N8
CTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGN
+
CC@FFFDFHFHHH>AHIEHFGHICHIIIIEGIIHGCH?DG7FFHGGGEEFDEEFFEECECECCCCCCCCCC?@C:?>CCCCCCCCCCC<BBCBCCCBBB>#
@6N9
GCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATN
+
@?<DD?DD:?FDF?@AEGEEAB+<CEGA8?F?::??CFDF?BF*B@??BDBFEIA5;8?7???B>BD7;@@C;.555>@=3::A><<B553@::@443::#
@6NA
CTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTN
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJJJJJJJIJIIJJJIJJJJJJJJFHHGIJIJJJJJJIJJIJHHHHHHFFFFFFEEEECEDDDDDDDDD#
@6NB
GGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGN
+
CCCFFFDFHHHHHJIIJGIIGFFHGHGIJIJJJJJBFHJIJGGIJJJIJJJJJJIIIJIIIJJGEHHHFFFFFFDCECCED;CCD>CDD<?@DCDDDCBB#
@6NC
GTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTN
+
@@CFDEDDHGFHDHIHGBHHIDEHIIIIIECGHHGGIDEEDHFFEDDFHHGHIJHEHGHHGJGIJCFGGIIGIJIIID@EHCEHHG>CHHD@B@;AEDEA#
@6ND
CTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCN
+
@@@BBDDDFHFHFGBHGIHIIGGEHGCFBHIIIIIIGIEIIIGIGHI@@FGHGFHIGCECEHHEH5?CHFFFFEE;AAAACCCCCCACCCCB?BBBCBBB#
@6NE
CTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCN
+
@@<DD;BDFFHFHIIFHBGEFG8EHEGHI<@F<?BFFCG@FGA@D??FHGIGHCAE;8;@;CEHHE>CHF:??@BC?AB;AB=8;<?2222:@>A@A?<<#
@6NF
CTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTN
+
@@@DDDADH8?FB@>EC?FEC?1?BGA?BGGGBB9BHGGIBAGIIICDC;=ACHHCEE7766>6;;5>@C;=;>:>:@@>3>::354+44:42499?C1+#
@6NG
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJHIIJJJJIIIJJJJJJIIJIJJJJJJJJJJJJJIJHEFFFEEEEE@CDDDCDDDDDDDDDDDDDDDDDD#
@6NH
GTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTN
+
CCCFFFFFHFFHHJJJJJJFJIJIHGIIJJJIIJIEGGIIGGJIJJJIHIGJIJJJJJJJJEHIGICHGIIIJIIJJIIJHFHHHFFFFFDACEEDDCCD#
@6NI
GTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCAATATTCA
+
@@CFBDBDFHHDHHIJJIIHJIJIIIGHIJJJGJIJHJIJJJJJJJJJJIJIJJIJJJJJJJJJJFFCGIJIIJJJIJGIGIJIJIIIGHHHGHHGFFF
@6NJ
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGN
+
=;8B4=B:CD?DFA<C<EHHAFHEE>FHC??G>@>:?FBDGCFHIIIBE-;FHHEH@EEHH=A>@@;DC9;;>C(;;>;?BB,55;;:ACACCC>4@(4?#
@6NK
CTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGG
+
@@@AD@DDDHFBB@2CFH;FHGII??F@FF<F@G7CFEH@GEEB<;(6;;;A>;@>@C::>A>A::@CCCCCC@3>AC@BCDCAA:AC@+2<BCC>BCC
@6NL
TTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCA
+
CCCFFFFB=ACDHHGIJJJJIJJJJJJJJIJIIIJJJJJJIEIIGIJIIJIIJJJJJJJIJJIJJJJHGHIIHHHFFFFF@;AECACC>ACDCDCDDDE
@6NM
CTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJIJJJHHHHHHFFFFFFEEDECBDDD>ADDDEDDD#
@6NN
GCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGACACCAAAAGACCATN
+
@@@DDDDDHHHHDD;@<CGGGGICHIG<DDGGHIIIIIIGIGGIFGEGCGGHHAEAHHEEECCCC(;?C??BBB@>CCBB?29<<<?CB@B@@BC@C?9@#
@6NO
GCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATGTTGAACAGATTCCTCCATCATCATAATGGCTTGGATGTACTCTTN
+
CCCFFFFFHFFGHJJIJJJJJJJJJJJJJJJIJJIJJJGIIJIJJJJJJJIGBHIEIIJJHIJJJJJJGIJJJJIHGHHFHFEDFFFEBAC@C;@@B5>C#
@6NP
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
CCCFFFFFHHHHHJJJIJJJJJJIJHIHGHIJJJJJJJJJGHIJGJJJCGHIHIJJIJJCEHHHHFFFFFFDEDDDDDDDDBBDDDDDDDDDCCDDDDDD#
@6NQ
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJGIJJJJJJJGHJJJGJJJJIJJJJJJIIIJJJHHHHHFFFFDDEEEEDDDDDDDDDCCDDDDDDECEDDDD#
@6NR
CCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTN
+
@BCFFDFFHHHHHJIJJJIJJJJJJJJJJJIIJIJJJIIJJJJIIIIIJJJJJIJJJIIJJIJJJICEFHGGHIIIJJHHHFHHFFFFFFEEECEDDECE#
@6NS
CTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFEFFFEEEEEEEEDEEEEDDDDD#
@6NT
TGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATC
+
@@@FFFFFHHHHHJGIIIIJJJJHIHGGIJIJJJICGHIGIJIGIIIJJIIGIJJJJJJJJGGGIJJHHHH?BDCBB>@CDDDDDCDDDCDD:?B9CDD
@6NU
CATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTN
+
@<@DD=AB?F4<3B@FHGHEHIBBBFFGCGGB<?*BBFHG>88C==@ADE7@E=57?AEBDE@>CAACCCC>;;;;;-;(,5>5>CCBB9A@@>CCCA58#
@6NV
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTN
+
CCCFFFEFHGHFFIIJGIIJJGEGGIGIJGEGGIIIJJJIIFHDFFGIGIJJFGIGBCGHIIIJGIJGHGEHGHGHEF@@DC>B>;?;@CCDDDDCCDDD#
@6NW
CCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCTGCACGN
+
@C@DDDEFHHDDBGIIIGGIIECGIIIGEHGHJFIEHICFAF@B;FHEG:=;BDDAEEEECC@B@BDDCCCDDC?ABDDCBCCCCDDDBD@BDDDDDCDD#
@6NX
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
@B@FFDFFHHHHFHIIJIJJJJJJJJJJJJIIIJIIIJJIJJJJJJJJJJJJJIJJJIJJJJJJJJJIJHHHHFFFDDCDDDDDDDDCCCDDEDDDD
@6NY
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCN
+
CCCFFFFFHHHHHJJJJJJJJJHIJJIJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFDDDEDDDDADDEDDDDEDDDDDDDD#
@6NZ
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@@@DD:DDFDHFF@FEG<:CGFEHIBHGE>DFH3BDC?B@GCEF>;FGG>FGAHGIC@>>;CAC2<'389>A@::>?B5?BCCC:>C>CC<>@@BBB<BB#
@6O0
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGN
+
@@?DFFFFHFHDABHGHIGIIIII@FIIIGIIIGGEHHIIIBHIIGGGBBFDHG;;@EBDFFCE>CA@BDDDDCCCC@ACC@CABBDDDD:A>:A@ACCC#
@6O1
CTATTTGGAAGCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTN
+
CC@FFFFFBDHHHGGIGIJJJJJBDHGICIIGIGHIIJIHJGEGGGDGIHIACCCDFHGIGIJGGIHIJIIIIIIHIGCH>CE>CED@D:>CAC>@CDC;#
@6O2
GTCCGTAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
@@CFFFFFHGFHFIJIHIJIGIJIIJGFHFIJIGGIJJGFG?FHIJJIIGIJGIIIJIJIGIGGGIFEEDBCEFECCEBBDDDDCCD9CCDCCDD<A@D
@6O3
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATN
+
?@@DDDDDBHFHHIIHIIIGHDF9CBHIIHGGGG*??@?DDGGIED9?<BDCGGIDII<CA@FGEGHHEF79>AC?/=;@CA@@>5:@5:?,5<&:>ADA#
@6O4
GCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGN
+
@@@FFFFFHHHDFGIIJJHIJGGIJGJIJJIJEHIIGGJHGIIIIJJJJJIJJJJJ8@G@FIIHIGGIIJHGHHHEFBEBDDCCDDBDB09BCDDCCDDD#
@6O5
CCCATGGGCAGCGCCTGCATCAGCAGCGGGGTGGCCATGCACATCTTGCTCACAGGCTTGGGAGGCTTGGGAAGCTTCATGCGCAGGTTCTCCAGCTGC
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJIJJJHIHFFFFFEEEDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDD
@6O6
GTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGN
+
@@@FFFFFGGDDHHIGIIEIFHHCFHIIIIIIGGHIIIGHGIEGGIHGIIIIIIIIIEIIIHEIII@FFGHEIIIIFHGGGDEGHHHGGFDFFFFFCCEE#
@6O7
CTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGN
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJJJJJJJJJJJJEIJJJJJIIIDGHIIHIJJJHIJJJJJ=DDDBDDDEDD@CDDBDDDBBDDCDDDDDDDDDC#
@6O8
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHIJJJJJJJJJJIJHHHHHDFFFFCEDEEDACDCDCDDDDDDDDDCDDEDDDDDD
@6O9
GTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGN
+
BB@FFFFFGHHHFIJJEHEHJJFDGIHIIGGIGIJIJIJDGIIEGFHIJJIJJJJGEHGIEHJI@EAGEEEHHH;@@ADFFED@C@BDCBCDDDCDDDDD#
@6OA
GTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCN
+
@CCFFFFFFHHHHEHJIEDHIJGFHGEIEGHGHGGHIJJEHIICHIJFIGG?BEFDDEDABCA=?CCCCCDDDCDCDDDDACDDDDEACCCCCDDDCDCD#
@6OB
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
C@CFFFFFHHFHBHIIGGHEIGIGHDHHIJIJGFFH?FHIIJIBGGBGGIJJ>EFFCBEFFFCCEEEDDCCDDDDDDCCDACDCCDCDDDDDCCDDEDDC#
@6OC
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@?=DD1A@F>FHDEG>>AAAB??AC?CGGHC9CBDFGDG4?F@FG>DBB?@?DFD@BE?GGHGIC:7?C;>BD;C@>.6>B5>@B,58?,>@?CB@28:
@6OD
CTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGN
+
@BCFFFFFGHHHHJJIJJJJJIIJJJJHIJJIGGHIJHHIJJJJGEHHDHHIIJJJIDGIGGIHIJJJJJIEGIJIIIJJHFFEEEFDDCCDECDE@CDA#
@6OE
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCN
+
CCCFFFFFHHHHHJJJJIJJJIJJJJJJJJJJJJJIIJIJJJJJJJJJJJIJJJJJJJJJGHIJHJJIIIEHHHHHGFFFFFFEEEEEDDD@BDDDDDEC#
@6OF
CTCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJCFHGIJJJIIJIJJJJJJJJJIIJJJJJJJHHHFFFFFEDEEDEDDCDDDDDEEFEDDDDDDCDDDDDDDDD<
@6OG
CCTTGGGTGCCTCAGGAGCAGGAGGTCTCTGGGCTTTACGCTGACGCCGGCGGGGGGCCCGTGTCTTGGAGGCTGCCTTCTTCGGAATGTACACTGGCTGN
+
?@@DDDDAFDHFAAGEE7FHHC@EGFAB?CDCHIHIIGGIDGFAEGAFGEECB@@BB8B@55;??CC3A>A?82<0<:@:CCC<>08?>4>>CCCC??CB#
@6OH
GCTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
?<@DFEFEDHHDHHG@EG:ACBACHA?C<ABFH8DE@<?BB90?BBFB*07BBGG=FGIGE@>76==B;;7?>;96;>;;>@CB=AB<<,::>3@@ACC
@6OI
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTN
+
@@CBDADEFDDFHEGFGIIIGIICGHHDECCFHHGHIGHFHGIIIG6DFFAGIIIHDEHHHB?DDD@AAEDBDDD?@CDDCCDCACDBDDDCCCDDDEDC#
@6OJ
CCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGN
+
CCCFFFFFHHHFHIJIJJJJJJJIJJJJIIJGGGIGJJJIHJJJIIHJGIJJIIJHHHHHFFFFFEDCEEDDDDDDDDDDDDDDDDDDD5@BBDDDCCDD#
@6OK
CCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGCGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCN
+
@;=DDB;D;<FA??AAF:3C:<F?H<+<AFFFCC?F1*11:BGII=800(.<F@F===CFDD;.@777=6545=C=;>55;A;55:A:@3>995:AB4:3#
@6OL
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
@@@FFFFFFFHHHIIGGIFBHFHGFHHIBCFDFGEHIH;BGIA99DCEEHHGEHHIJIAGIGHCHI/A?BF>>;>CAACDDCCADDDDD>C?C?BDDC@B#
@6OM
CTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCN
+
BB@FFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFEEEEEEDDDDD@CDDDDD#
@6ON
CCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCN
+
CCCFFFADFHHHHJIJIJJJJJIJIIIJIJJIJJJJJJIJJJJJJIJJJJIJJJJJJIIJJJJJJJHHHHEFFFDFDEEEECBDDDDDCCCDDEDDDDDD#
@6OO
CCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGACTTCGGGTGGGACTCGN
+
CCCFFFFDHHHHHIJJJJJJJJBFHJJJGIJIJJJJHHHHFFFFFEEEDEDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDDDDDDDDDDDD?BDDDDDDD#
@6OP
GTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTN
+
CCCFFFFFHHHHHJJJIHIIHHHJJIIJJJHIJJJJJJJIJJJJIJJIIIIGIJJIJGJJJJHHHHFFFFFFDECECEDDDDDDDDDDDDDDDDDEDDD?#
@6OQ
CGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTN
+
CCCFFFFFGHHHHIJJJJJFHIHHIJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJHHHHHFFFFDEEEDDDDDDDDDDDDDDDDDD#
@6OR
CTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCAC
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJHJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJDFFEEEEEEEDEDDDDDDDDDDDDD@BDDDD@CCD
@6OS
CTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTN
+
@C@DDFFFHHHHFIIIIJEHHJJJFHGEIGGGEHIJIGIEFBBFEHIIIGCHCBFFHG@HGAGHGJFHDEHHEFFFBEAEDCCBBACCB959<A3@C@A4#
@6OT
CGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGN
+
CCCFFFFFGHGFGGJJJIIJJIGHIJJJJJIIGIEHGIIBGIGJJIJIGGGJIJJJJJJJHGHFHFFEFFECCCC?AABEDCDDDCDDDCCDDDDDEDCD#
@6OU
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@C@DFFFFHHHHHJGHIGHIFHIIJJJJJJJJJIJHHIJJJJJJJJIJIIIIJJJIJJGGIHGJJJJIHHHFDDBDDDDCDCDCCDBDDEEDDDD>@CD
@6OV
GTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGN
+
@?@DDDD?FBFFHIIHGGIII<:<CAF>CDHGIGEGDFHGGH4CDCGFHIIB*0BDGEH>FAEFHIGIIDFAG;FHGGHGE;@=@HHFC)7@DEE>DCC>#
@6OW
CAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
@@@DFFFFDHHHFIIGHGIJJJIIJIGIJDHHIJ?DFGHIJIJHIJIJJGIGJJHHHHGFDFEEFEEEDEDDDDDDDCDDDDCDBDDDDDBDDDDDECD
@6OX
CTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGGACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTN
+
@?@D7;DAA;:CF<C?CFCFEEGIGGDA<@:BB):?FF@(8?D@B<FB@FAAF=DAEG>=A=??BBBCCCB89@@5@>A?A3>:>@AA:@@:@CB5>B18#
@6OY
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATN
+
@@@FFFFFHHDHHGIGBDGEEFFGGIJIIFCGGDGFGDGIHGHBGGGIFGGDHCG8@B@EGEEECEEFFFEFF3>C;?B/>CCCDDCAACCDBBCDDDDC#
@6OZ
CTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCN
+
@@@DDBDFHHBFHHIGHGIBDHHHHAFCEGHGIIGGDG>BGHBGHFGIIII?HIIIGGGGI>FH=@GCEIEEEHFFFFFFCCEEEDDDDDDDCCC>A?AA#
@6P0
CTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTN
+
@CCFFFFFHHHHHJHIJIJHIIJJJJJJJJJJHJJIHIJJJJIIJJJJJJJJJJJJGIIHHHHHHHGFFFEFFEEEEEEDDDDCACDDDDDCDDDDDD>C#
@6P1
GGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCN
+
CCCFFFFFHGHFHJJJJJIIEIIIIJJGHJAFHHIJJJJJJGIJIJJJIGCIHIGGGHIIJIIHIGHGFFFFEDECCDD@B?CAABCCDDDDDCDDDDCD#
@6P2
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGN
+
@@CFFFFFHHGHHJJFIJJIIIIIHGJIJJGIJJJIJJIHHIIJIJI7CHHHIIJJIJCGHHHHHFFFFFDEDDEDDDDD;?BDCDDDDDDCDDDDDDDD#
@6P3
CCATCATCATAATGGCTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATC
+
@C@FFDFDFHHHHIIIIGIIBCHEHHEHCHIIIIGIIEBGCFHG9B<GDGHHIIICGIIIIEG>FAFGHGIFIIIGCEEHECDFFDDEEE@:A@C;@
@6P4
CTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJIIIHIJJJJHHIJHIJJIIJGHIJGHHHFFFFEEEDEDDDDDDDDDDDDDDDDDDDDDDDEDDDDDDD#
@6P5
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
CCCFFFFFFHHHFHIIEHGGJGIJJIIIJJEHIFHIGGHIJJJJJIIIIBHJJIGHEGHIIEHHHHFFFFFFDCEDCCCDDCCDDDDDEE@C>CCCCCC
@6P6
CCCTTCAGCACCCCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTC
+
@<@DBDBDFF?DD>FDB?FF:CFHHE4C?EFHHG@DFGAG@<DDGHB4B;BFBDCH=FF@=CCDFHI;7@@DHGHHHF@EE
@6P7
CCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTTTN
+
@@@FDDFFHDHBF;GHIF<FHGEHGBHIIIIICGGHEGGGGGEHI6FCC=CGGGIF)=CGCAAAEEEF@D@BCCCCECBBBCCCCBCBBACCCCCCB?<@#
@6P8
CTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
CCCFFFFEHHHHHJJJJJJDDDDDDDDDDDDDEEEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDCDDDDDDDDCDDD
@6P9
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CCCFFFFFHFHHHEGHIGHJJJJJGIGHIGIJIJJIIGIGGGIJJJJIIJJEHGIIII5ADBEECDCDDDDDDCDDDDDDDDDDDDDDD<?BCCD>>CCD#
@6PA
TTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGN
+
CCCFFFFFHHHGHJJJJJIJJJJJJJJJJJJJJJJJJJHIJJJDFHIJJJJJJJFHHHHFFFFDEEEEEDCDDDDDDEDDDDDDDDDDDDDDDDDDDDDD#
@6PB
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATN
+
CCCFFFFFHHHHHJGIIJHHJJAFHIHIIJJJJDHIJJHIJJJJIJJJIJJJJJJGHIJHHHHHFFCFFEDEEDDDDDDDDDCDDEEEDDDDDDDDDEDD#
@6PC
CACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTN
+
@@<DDA?DH>FHHIE;AFFHBFHG<<A3+<AGFFCB>AFHCCBFEEGIIFI>FFEGIIGHDFH8=BFCFGEAHEGAEHGHHHGEF>7;@BEE@;@@>@DC#
@6PD
CCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGAT
+
CCCFFFFFGHHGGJJJJJJFIJJJJJIIIJJJJIJJJJJJJJJJJJJJJIJJJJJIJJJJIJJJGIJHHHGHFFFDEEECCDDDDDDDDDDDDCDDDDC
@6PE
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATN
+
@@@;BDDDFFFFDEFFF<F+A??EHF@@EHBFD<DG>F9?*00?DG99?;BFEA?FE65CE4;CAEF7;;@@D@>;;=??ABA@;@ABB:9<B@(>>ABB#
@6PF
TCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACN
+
CCCFFFFFHHHHHJJJJGIHIJJJJJJJJJJJJJDHIJGJJJ?FHIGIJJIIJ@GHIJHHGHHHFFFFDEEEEDD9?BDDDDDDDD>@CDDDDDDDDDDD#
@6PG
ACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTC
+
@@CFFFFFHGGGHIJJGIIJJJJJJIIIIIJDGIGIJIJIDIJJJIHIIHIJJJFI>FHGHGFEFHFFFEEFFEEEDCDDEDDDDDDDDEEEEDDDDDC
@6PH
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGN
+
C@CFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJHHFHHGFFFDDDDDDDDDCDDDDDDDDEDDDDDDDDDEDDDD#
@6PI
GTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTA
+
CCCFFFFFFHHGHIJJIIJEIIJJIIIIIIEIJJJJJJIGIJJJJIGJGGEHECHGIGHGHJJGIIGDIIHHFFFACEEEDDC>AC@CDDDCDDBACC@
@6PJ
CGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGN
+
@@@FFDDFGGHFHJJIJJJJIJJGEIIJJIJIIIGGHGDFHIIIHIJIIJIJIJHFDDDBBDDDDCDDDDDDDDDDDDDCDCDDDDEDEDDCDDDDDDDD#
@6PK
GCCATCAGCTCTCGTGAGTGGTACAGGACTCTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCG
+
B@@FFFFFGHHGHIHIGICFHAFHIIIIIGJGIIJIJIIJGIIGIGGIJCFHIJJJGJIIGIHHDHHHHEBEEFEEEEECCCDECD@CCDDDDDDDBBB
@6PL
CTCTAATTTCATGTTTTTTATTTCTTGGCTCTTTTAACCAATCTGTTCTTGTAATTTTGCTAGAACTTTATCAGGAGTTTTTAATTTATCCTTTAGCTC
+
?@@DD+2B?,A<BAE:CD6AF><4A<<3+?*?*:?***1:?:???09*99<0*0***0*)/)))))/8@)/...)75A>)7;(77;37@(.(((.(5>(
@6PM
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGN
+
@<??DAD22C?1?FG;E3A@EFCDF8B<:CDEFCFGECFE<DD(?*=;CB@CCDCEEF6?@D:6;@=;>BB:@A>AABAA@A<285><?<>A((4::AA:#
@6PN
TTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTN
+
@CBFFFFFHHHHHGGHJIJJGHIGGGFGGHIJJJJIJG?DHIIIHGIHGIGIIGIIJJJJJJHHGHFFDFFFBCCDDDDDDDC5>ADDDDDDD?CCCCDD#
@6PO
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFHHGHHIJJIJGHIJJIJJIIIJJIJJJJJIIJIGJJJJIHEHGIJJJGGIHHHFHFFFABBDDDCDDCBD@BBCDDDCCDDDCCDBBB>BBD#
@6PP
GCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATAC
+
@@@DDEFDDHADFHDGIGGIGHIAF@DHGHIIGGEHHGCHGEGHGGHEHGEHIBHGHEHGDC.=@CFHIGIFE<BCCB(;>@;>AB;CBCCCCCB@<9<
@6PQ
CAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTN
+
CCCFFFFFHHCFHJHIJJJJJHIJJJJJJJJJJJJIJJJJJJJJIJJJJJJJIHHHHHFFFFFFEDEEEDDDDDEDDDDDDDDDDDDDDDDDDDDC>CDD#
@6PR
CTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGTGAGG
+
CCCFFFFFHHHHHJJJJJJIIJJJIJJJJJJJJIIIIJJJJJJIIJJJJJJJIJGHIJIJJJJHCHHHFFFFFFEEEEEEEFEEDDDDDDDDDCDDDD
@6PS
GTCGGCTGTGTAGAGGAATAGCTGGAAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
?=8A?DDDHFCFBGGHGGGABHHGC+?EB):CA0??DGIEG?F@C=>FHGH;CE@@AHHHEHEFDE3=AE;CC?AA?(:AA@C?BB<>?@C>:ACCA@>C#
@6PT
CGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTGCTCTCAGGCTN
+
CCCFFFFDHGGGHIJJIJJIIJIJJIIJJJJJJJJGIJIJGGGIIJJJJIIHFJJJJGGHHHJGIJIJJJIGEGHHFFFFFDDEA?B?=?A@CCCDCCDD#
@6PU
GTTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGGCTGCCCATAGGGTGCAGGGGTCTGAGCCN
+
@@@DA=:B?:FFFIIABB@08>ABBB(3>333>883@?+8A82()++823+(93(33+9(+::34:@BB5@&&&5(+<3+(+((+2+(+()0&)++(:@B#
@6PV
GGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGN
+
@@?DFFFFHHHGFHFFDDBDD;?BDDD6:BDEEDEDDDDB<@BDBDBDD8CCDDDDEEDACCDDCDDDDDDDDDDCDDDDDDDDDDDD>CCCDDDDBCDD#
@6PW
CGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTN
+
CC@FFFFDDFFHHIEGGGIIGGDFGIHFGE?DGIIDHGGGHGIGHECFHGDIDGGEEHFFDECCECE>ACDCCDDACC@@DDDC:ACDAAA?ACD@CDBB#
@6PX
GCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTN
+
@@@ADBD?ADH8FEEHIICAG<FFG@F09BEG@?9BBCFGHGA>GEC@EBHDECA:ACCB95ACCCC5;@ACCDADA>>28<?>59@9?CDAD>44@3@>#
@6PY
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
C@CFFFFFHHHHHCGHIIJJGJIJJJJJIJJIJIJJIJDGJIGFHIJJGIGIJJJJGIJJJJEIHIJJJJJII?EF?BBECECEECCDE@CDCDDCDDDD#
@6PZ
CTTGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFBDDBFFBDGHADFFEHIIGIIIICGEGFIGIGIIIIHGHIHGGIIIIIIIIBDFHG8CE;DEDGACEHHFF3?CBAECC(5<@CCCB5??+<@
@6Q0
AGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCN
+
@@CDFFEFHHHHCEGIEHIJAFFGHIJJGHIHHJIFHIJIIGGICHGIJJJJJAGHIGGIEEHH>BEFFFEDDDBDDDDDDDDDEEDCDDDCDDDDDCDE#
@6Q1
TGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTN
+
CCCFFFFFHHHHHJJJJJIIJJJJJJJJIIJJJJJJIJJJJJJIJIJJJIJJJIJJJJJJJJJJJIIIGIJJJIJIGJIJJJJIJJJIIJIGFEHHHHFF#
@6Q2
CGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCN
+
@C@FFFFFHHHFHJIHHIEGIIJJJJJJJJIJJJJJJJJFHIIHHHJGFEHFHFHHGHJGIGHHHHGEFFFFFDCEEEEED;ACDD>:@CCCDCDCCDDC#
@6Q3
CCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTA
+
CCCFFFFFHHHHGJJJJJJJJIJJJJJJIIIJJJJJIJJJJJJJJJJHHIJJJJJIIJJJJIJIJJJJJJJHHHHHGFFFFDCDDDDDDDDDDCDDD>>
@6Q4
CTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATN
+
@@@DDDDDFHHFDF@CFBHHGIEIACFHGIIIGGDBFFEDGHFBFGIGIGIBGFIIGGIIIEHGIIGHAGEHHHHHCCEEEEECCCCCBCCD@ACCCBAC#
@6Q5
CAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTN
+
@1;;=D>A;D7CC@FAAEH?;F80-57+8ABBB@A838@8>A>+8>AAB?BB7<@?AABEBBBBA9>@::A:AAAB@<@>B?<>?493:A4>?@AA(4?@#
@6Q6
GGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGAC
+
CCCFFDBDHFHAHGBGGGIIBGHEIGGIIEHHCGHIGGGGIIIBGGHGCAFAGIGGGGCGH7@D?AC:?C@BEFFEDCCCBB;@CCDCDDDCDBDDD@
@6Q7
CTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTC
+
@@?ABDBDD>?F;ED<<<:<FHF<GECFAF;:?D@FG@FCF@*90??GE??D8DDFFFF@F;.8CFC>A77=97?A>7A7;;@?BDB6;@CB;@?AD
@6Q8
CTGGTGCTTCCGGCGGTACACTGCAGGTGGGTGGTCAGCTGCAACATGGCCTGGCAGCCTGGCCCTTGAAGCACTAAACTCTATTTCTCTTTCAGGATTCN
+
@@?DDDDFGHHHGJJIIGIGHJJJIJIBFGHHFHGHFEHHHFFFFFEEEEEDBDDCBDDCDDDDDDDDCCCCDCDDDDDCCDDDEECDDDDDDDDDDDDD#
@6Q9
CGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTN
+
@@:DDADD@D?FFAFHIGGIGHC69;7?BBCC69BB6B67@>AD>>@CBB@BB@8<8077++>C@C4>C@DA3@C>>@5@><>>>A>8>>ACC8A@<A8>#
@6QA
GTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTACTTTTCTAACTCTTCACA
+
????D>;A,AD?A:2A<E,:CECBACEDEEAE4?EEB9*1?DDAD3?3?D*?4?<<89<?/B4))-@A@(.=C))).7=?))..)7>6;;>>(--;55(
@6QB
CGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCN
+
CCCFFFFFHHHHHJJJJIFHIIJJJJJJJJJJJJJJJJJJJHIJIJIJHHHGFFFFFEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCDDCDDDD#
@6QC
GTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACA
+
BBBFDFFFHHHHHJJIJJJJJJJJJJJHIIHIIJJJJJJJJJJJIJJJJJJJJJIJJJJFJJIJJJIJJJJHHHHHHFFFFFFEEDEEEDDDDDEDDDD
@6QD
TTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAA
+
@@@AD?DDB<FDFIAFGGGII<CEEHDBCHHIIIIIEGHH>F?FD@CEGHIIEG@FHBE9B?DGEHGDHGE@CGIGGGGEGEGGGGFFE<DEEEEBACD
@6QE
CTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTN
+
@CCFFFFFHHHHHJJJJJJJJJJJHHJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIJIJJJJJJJJIJJJJJIJIIJJIHHHHHFFFFFEEDE#
@6QF
GCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATN
+
@<@ADFFFHHGGGIIIIIIIIIIIGGIIIIIIIIGIGIIIGIIIIIIIIFIIEHEGIIIIIGIIIIIIIIIIGIGIIIIHHGHHFFFFFFFCEECECCBB#
@6QG
GCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTC
+
@<@DD;DDFHD???EAFH>>GH@FEGCA>DD)6)0?B889<C8=.=366.85:6'..;;@;>@6;@A@C>>=;>:@C?55?52?B?@70084>C9?AC(
@6QH
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJGHHIJJIJJJJJIIGHJJJJJJJJJJJJJIJJIJJJIJJJHHHFFFFFEEEEEDDDDDDD<CDDCDDD8ABD
@6QI
GTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTN
+
CBCFFFFFHHHHHJGHJEGIHIJIJJJIJJJJJJJJJJFHJFIIIJJHJIHIGIIIIJJIJJJHHHCHFFFFFFEEEEED?CDDDACCDCDDDACDDDCD#
@6QJ
GCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCN
+
CCCFFFFFHHGHHJJJIJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIJJHEHHFFEFFEEEDBDBBCDDDDDDCCCDDDDDDDDDDCDDDDDDCDD#
@6QK
GTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTN
+
@@@DDDFFFFGGHIEFGGIIGIGBGE=GEEHHGEEEEGHIIIGGIHEGIGI>9<DFHCA2DFG=8FHIGAA@GIDD?A?CEEHFFFFEFBCCCEED@CAA#
@6QL
TCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCN
+
@@@BDEFFAFDDDDDEHEGIIIIIIHGHGIEF@GIIEGIFEFGCHIIEIIIDHIEH?F=BBHGGIGHHC6AEHGEBDEFECCC@DEDEDDDDDCC@CC;@#
@6QM
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
?8?D?ADB;CDDAEEDE<3@CA8CD9D@D?DA?2DDCDDDD@@>@@@CA@DEIDD>=AC2?ADDAA>@@AA>;>AA>A>>>>BA>>>A>>>>-(09<AA
@6QN
CTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCN
+
CCCDFFFFHHHFFGGIGHIIGHHJGIIEIIGIJEIJIJJIFFECHGGIIGGIIGHHHGFEHFFCDDDCCBDCCDDDEDDDDDDB?@BDBBDDDDDCCDDD#
@6QO
GCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFD<@DBDDDDDDDDDDDDDDDDDDDDDDDDDDD
@6QP
CCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCG
+
@@@D?DDDFD=AF:EAE@H3ABFFFEFIFEGII@GFF6@F8;@EEFEEEFFF=BD@CACCCB(>=?;>5<9@BBA>@?05>9>B3><B(8@BBABB@?<
@6QQ
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
CCCFFFFFHGGHGGJJJJJGIJIJIJJJJJIJJIJIEGGIJJJJJJJJIEIJJIJIIIHIJJJI;BDD>CCEEDDCDDDDDDDDDDDDDDDDDDCDDCDD#
@6QR
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTA
+
B@CFDDFFFHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJJIJIJJIJJJJJHHHHHHFFFFFEEEDEDDDDDDDDDDDDDDDDDDD9BDD@C
@6QS
GGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGN
+
@CCFFFFDHHDHHIBGHHHIJJGIIJIHIHIJJIIJIJJJEAAHGIIJHGHHFFFFFFECEEEEEDEEDD@CDDDDEDDDD@CDEDDDCDDDDDDD?C>A#
@6QT
CCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAG
+
@@@DDD?4A?FAFFHB@BBFFGDHC@DE?EB*CGHG@DG?BB4<DHG@D<BFBGHB<B488=CC@FD@E>GHEEE9?<?@CCC>>ACBBBB0502(3
@6QU
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJHHJIJJJJIJJJIJJJJJJIJJJJJJIJJIIJJHHH?BDABD?BDDDDCFDDDDDDD@BD9ACDEE#
@6QV
TTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGA
+
CCCFFFFFHHHHGJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJIIJJJJJJJJJFFIJJJIJJHHHHHHHFFFFFFCEDDDDDDDDEDEDDD
@6QW
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJHHIIJJJJJJJIJJIIJJJJJJJJJJJJJJJJJJJJHIHHFFDEEEEDDDDDDDDDDDDD?CDD
@6QX
GGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCN
+
@CCFFFFFHHHHHJJIIIJJGHGHEHGGFFFFECCCEBEDCDDDE@CDECDDDBD@CCCDDDBBBBDDACBDDCDCCDCCBDC?ACDCCCDD>ACCDDCD#
@6QY
CTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTN
+
@BCFFFFFHHHFHIJIJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIIJIJDHIJIJIJIGIJJJJIIJJEHHHHHHEFFFFFFEEEEE#
@6QZ
CGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCN
+
BCBFFFFFHHHHHJJJJJJJJIJJJJJJIJJJJJJJJJJJJJIJJIJJJJJGGHHHFFFFFFCEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDCD#
@6R0
ATTTATTTTCCTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGN
+
?@@DADEDDHHHDIIGBFBGGEECF:CGGB>DHIDEH@?CDD>9DB@<GIG@FAGC3?9??1=CHGGIIEHFHDEEEBD>C=B;CDD5;@?B:=;?CD@B#
@6R1
CTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTN
+
CCCFFFFEHBFFDCHIJJJJJJIJJJJIIJJJJJJIJJJJIIIIIJGGGHIIIIIIIJJGIIJJIJGGIEIIIJJJJJGHHEHFFFFFFFFCEECEDCED#
@6R2
AGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGGGN
+
=?:B?DDAFDFFFIIIIF9EFDDBFE3?DFAFC?39BFD@DFICFD??DFA@FF@FFEFI@DA@D3AEFFFBDBDCCCCB59==??BB@:@B>:4:(:(5#
@6R3
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
CCCFFFFFHHHHHJJJJJJJJHJJJJJJJJEHIJJHIIJJJJJJJJJIIJJJJJIJIJIIIHHGFFFFFFDDDDDDDCCCDDDDDDDEDDDCDCCDDDC
@6R4
GTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATN
+
BCCFFFFFHGHHHJJJIIJJJIJJJJJJJJJJJJJJIJJJJJJJJIIJJJJJJJJJIIJJJJJJJJJJJJJIIHIJJJJJIIHHEHHGFFFFDCDDEEEF#
@6R5
GTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCN
+
@?@DDDBDFHHHGIJIGGHIGIIHIEEHEGGHGGHFDE@DBHHIGGI@??BGHIJDGGGHIJEIJIGGEGDGGIJJEHAEGEEHCAAE>BE@CCCEC@CE#
@6R6
GGTTGCAGGAGACAGGCCCTGAGACCCATTCATCAGCTGTGTGTTCTGAATCTGCATCTCCTCAGCCTCAAACTCCATGAACCTTTCTGCCATCTCATA
+
;??AD;D?DAB2:C@72A@EFDEE>EEDEEIEB4DBDEC999BBD@DE?<@DDEIC>C:ACED>;@>;@CD=7=?AD>AAAA@AAAAAA;AA>AAA>:>
@6R7
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@CCDFFFFHHHHHJJJJJJJJJJJJJJJJIJJGGJJIIJJIGIIJJIIJIJJJJJJIJJIJJHHHGFFFFFFEDDCDDDDDDDDDDDDCCDDDDDDDD
@6R8
GTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGN
+
CCCFFFFFHHHGFIIJIJIHHGIJICHIGGIFDHJIGIFHIGHJJIJGGEFHG@FDGEHGHGIHIIIIJIEIIFHEEHGGFFFFFFAECCDEEDACCCDD#
@6R9
GTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCAGATTCGCTCCAACCAGGCAGTTCCTGGTGGCCAGGTCTCGGTGCACAAAGTN
+
<?@DDDFDD?FFHDAGGIIHHIGC?@8CFG;?DECH?FDGHGGFGHGIIE@FGIIIIDEC@EAACHFDDFFDAAC@>;??AC?9@ACC>?589@ACABC4#
@6RA
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACCTGAGGAAAGAGTCACATTCTGCTGN
+
CCCFFFFAFHHAFBHGGHHGEHHGEGHIIIIIIIIIIAFHGEGEIIGDHIIHGCHI5:B=@@ACCC?9>BBCCCCBCB?C?C<98ACCCCCACCCC>CC@#
@6RB
GTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGN
+
?=+=:BDDDCBFA@A<EFHGII<HGGGGCDF>?DGBFHHEGH>GC9*9B<FC@8B1@FEECA:EIHHHB>B9?=AC>A->CACDC>A@CCAC>:@CC>??#
@6RC
GCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCN
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJJHHFFFFEEEEEEFDFDDDDDDDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDDDDDDDDDDDDDCD#
@6RD
GCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTG
+
?@@FDFFFHFFFHI<CEFCECHIE@BHF@FE93?FE7?GGHIFII@BEGHHGHIIIHFHHD=AHEF@D;BBD;AB@??BDDDDDACDCCDDCDDDDCDA
@6RE
CTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTN
+
???D?D?DD>:DC<E::EE??FBB:AEEFFEEI@93E?ED@DAB@DDDA?9?9B<//99?<B;BB)@CCCDCE>AEE;?A?;)=@@A<A@(.6@(6>BAA#
@6RF
TCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGN
+
CCCFFDFFHHHHDGIJHJJJJJJHIJJIJJJJJJJJJJJJJJIJJJJJJJJJJHHHHHHFFFFFEEEEEEEDDDDDFDDDDDDDDDDDDDDDDDDDDDCD#
@6RG
CGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTC
+
CC@DFFDD?HHHFIGHIIIGGIIIIIF@DGD@FH?FHIIGHIHIGIIIGFGEHIGIHAEG5?CFDECACDBBDBDCCCDCDDD@>?C>A@@C>>@BBC
@6RH
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@CCFFFFFHFHHFGGIJFFHHIFHGGGCFHGHF>CFGGJIIHIIFIJJJJICHGIJJJIJIFHHHEABDDEDEDECACDDDDEDDD@BCDA@C@CDCA
@6RI
CTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTG
+
CCCFFDFFHHHHHJJJJJJJJJJJJIJJJJJJJJJIJJJJIJGHIJJJJJJJJJFHGIJJJJJJJIIJJJJJJJHHHHHFF
@6RJ
CGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAAC
+
@@<DFF?DHDFFFGACG@FGHIBHDBB?BD@BBBBBB6@BDDDCBD@B@BDDDDB?BC??ABB58BCDEDAC@<@>?CCC>CCCCDA?BBCDDB@BCCD
@6RK
CGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGN
+
@@@DDF?D>FFHHFHHIGIIIHGIGIIIHGHIGIGEGGHEIFHCHIIIGHGIIIIIIIIEIIIIHGHGGHFFFDBACCD;@@CCFDD>CDDDD:CCCCDD#
@6RL
CTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCN
+
CCCFFFFFHHGHHIJJJJJJJJIJJJJJJJJJJJJJHHIIJIJJJIJJJJJJJJJIJIJJJJJJJJJHHHHF@DDADD9?CCDDDFDDCC>CD>@DBDDD#
@6RM
AGAGGAATAGCTGGTAGGAGGGTAGGGTGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATN
+
CCCFFFFFGHFFHIGHIIGIIJAFFGAFFHGIJDHHIEGGJIJIJJGIIJJJJJJ;BEFHFFFFED>AECEDDDBBDDDDDDDEDEEDDDDDDCCDDCDC#
@6RN
CTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATN
+
B@@FDFFFHHHHHIJJIEIGIGHHIJJJIJIIJIJIIJJJFDGGJIJJJJJJJHGHJJIIJJJGIJJJJIJJIHGHHGHFFFFFFFDECECEDDDDDDDC#
@6RO
GCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGN
+
@?@DADDAD<CFDGDBDED;B>AEHG=FEB1?@?@@?DGDDGG@;0:0099@@>3>?C+3+::344<>>A82<9?88+>@CCCC:(+3@@:44>:C@C79#
@6RP
CCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTA
+
CCCFFFFFHHHHHIJGGCFHIJJJJJJJJIJFFGIGIIIJIJIJIGIIIJJIIIJJJGIIHHDHHHHHEEHFFEFDE;>CACCDD?C
@6RQ
GAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCN
+
@@@DFFFDFFFFHJIGEEHGHJJJFFHHGIGIHBGHGEGGHIJGEBHGGDEGHDCBBEFF@CEDCEE@CD:@B?BABDDA@?CDDDDDDDACCDDD?C?B#
@6RR
GCCTTCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCC
+
BCCFFFFFGHHHHJJJJJJJJIJJJJJJIJJJJJJJJGIJJJJJIJJJJJJJHHHHHHHFFDDDDDDDDDDDCDDDDDDDDDDDCDDDDDDDDDDDDDD
@6RS
ATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCN
+
==?DD?DDDFFA:2AC:CH?<B<FEH??C<FC?FF?0@D9*:?FGDE?B?FF?CCCFI;FF;EECFFFFDBDBD3>ACCCB=@BBBBB:>5,5,55(+:@#
@6RT
GTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACC
+
?@@FBDDDGHHHGAFHHIG>EGBFHFHHGIJIJJIIIGGIHGHGGIIGHIIIFIDIIIHAAHIIDEHAEEEDFCDDCDBDDD?:@C@A:>C(4>BD>A
@6RU
CCTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGGGGGAC
+
CCCFFFFFHHHHCGHGGGIJJJJJJJGIGJJJIHIIJIJJGIIIJIIJJJJJEIIDIEHIIJGHHFFDDDDDCDEDDDDDACDDDDCDDDDDD(5@D>B
@6RV
TGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCN
+
??;DDADDFFFHDHEBHEFAHCIIGIICIIBHHIIIIIIIGIBFIII@FGEGII;?F:DG7;A;@FDEHE@9>EC>EEDEEECBBCCD>@CCCCCCCA>>#
@6RW
TTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCG
+
@CCFFDFFHGHFBEGGGHGGGIIIHHGHIGIJJIBGGGGEIJIIJIIFHIDFHGHJJEIGIGIJJGEGGIIJCHCEE?EEFFDEFDDCEEEEDDCA@CB
@6RX
CTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGA
+
CCCFFFFFHHHA<<AEHIJJJJJGIJIIJJJJJJJJJJJJJJIJJJIIJJJIIJJJJHHHHHHHFFFFDDDDDDDDDDDDDDDDDDDEDDDDDDDDDE
@6RY
GCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCN
+
CC@FFFFFHHHHHJGGGIIIJIIIJJJJJJJHHFHIEHIIIIGHIEIIIIJJJJJJGGIJIIJJIHIIJHHFDACCDCBBBDCDDDEDDDDDDDDACDDD#
@6RZ
CATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTN
+
@@@DDD=AD?ADFFGHDHIGH>CAEBDGHGHHCEEEEBF@DDDFDCD<B??FBD<FGDAHCDHHEHDDGE=@@=DHH>A;A:;;A@C@;?@;;@A>?;BB#
@6S0
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJCHHHIJJJIJJJIJJJJJJJJJJJJJJHHHFFFDEEEEDDDDDDDDDDDDDDEEEEDDDDDDDDDDDDDDD#
@6S1
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCN
+
CCCFFFFFGHHHHJJJIIJJJIJIIJJJJJJJJIIIIIJJJIJJJJIGIGIHJJIIJJJIICHJGGIJJIHHHHGFHFFFFCEFDEEDDDDDD@DCDDCC#
@6S2
GGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
@@=DDEFDHHHHDGIBCHIDHIBDHGHFHI>GEHEFGIIEIIJIGGGIEGAECHIGGHGGGJICCE=AEAEC>DDCDA<ABCBD@5;8?BB-<@>>3@
@6S3
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFDEDEEEDDDDDDDEEEDDDDDDDD
@6S4
GGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGN
+
??<DD:AD<A?:DEEDA<CAFCCEFEIIEEEEE?DAD8BDBDEII>?9?8BCAD@;5@@CDIE;C;:(',??A@@88?;>A>>A?9895>9<1>>>AAA1#
@6S5
GGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
CCCFFFFFHHHGHJJJJJJJIIJJJJJIJJJJJJJJJJJJJIJJHIIIJJHIJGGIIHGHHGFFF@CCEEEDEDDDDDDDCCDDDCDDDDDEDDD@CCD
@6S6
CTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACN
+
CCCFFFFFFFFHHJJJJGHIJJJIJJJFGHIIHGIJJJIIJIIJJJJJHIJJJJJIJJJJIJIIHHHFFFFEACDDDCCCDDDCCD?CCDDDDDDDCD@C#
@6S7
TTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACN
+
CCCFFFFFHHGHBFHIEHGHFHIIJJIIIGIJJIEIGIGGGIJFGGHIIIIHIIIAAFGHGHEEGGIIHCH@DFCF@DEEEEECDC>ADDDDCCCDDDED#
@6S8
GTCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCN
+
CCCFFFFFHCFHHIJJJJJJJGGIIJIIJJJJHIHIIJJJJJGGIJGHFFFFEEEDEDDDEED>CCDDDEEFEDD@BD@CDDBDDDEEEDDCDDDDDDDD#
@6S9
TGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGAC
+
CCCFFEFFHHHHHJIJJJJJJJJJJJJJFHIJJJJJJJJJJJJJJJJJJJJJIIIIJIJJJJJJJJJJJJJIHHHHHHFFFFFEEEEEDDDDDDDEDDC
@6SA
GCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCN
+
CC@FFFFFHHHHHJJIJJJGJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGGJJFHIIGHIIIHHHHFFFFDDDEEDDDDDDDDDDDDDEDDCDDDD#
@6SB
GTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTN
+
?=?1AB?;D,=CF9BF4EFDAE<BC+CE+AD442CF1?9C3DFFIEF9?*0**0??D*/9BBF@A>>CC:(8=CE3(7))77?BD>B3))6>@>6;(;>>#
@6SC
CTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGN
+
CBCFFFFFHHHGHJJJHHJJJIHIJJJJJJIIJJJJJJJJJJJJJJJJJGJIHDEHHHHHHHFFFFFEEEEEEDDDDDDCDDEDDDDDDDDDDDDDDDBD#
@6SD
GGTCTTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTN
+
@CBFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIHIJJJJJJJJJJIJIJJJIJJJJHHHHFEFFFFDEEEEEDEDDDD8?@D<ACDEDDC#
@6SE
GCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACC
+
==?B::DAFFHBFGH4EF>IIGHEGEBGGGGFFHGDDHG?DC9CDEEEGIGBFAB8<BG?>E@DEBD@@@@@@;;->@5@@DCCACCCDECCC3@5><9
@6SF
CCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAA
+
+1:DADBDD?C8822<CEDFF4CCF9A+2+++<AC4?E*?D3*?B?*?9?49DD;D?*/9BDEIE48.@C>@;=7)7))667)7;;;7>(6;>:;>;>A
@6SG
CAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTN
+
@@CDDDFFHHHGGGIJJIJGEHEHIIJIEHIIIJJJJIJJGGGIIJIGGJIIGGIJIFHFHHFFDFFDD@EDCCCDCDDD==<<CDDDDDDDDDDDDDDA#
@6SH
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTN
+
@CCFDFFFHHHGHJHIIIJIGIHIIJGIJJGHIIEIIJGIJJJIJIJJIEDHHIJJJJIEHIJIGIIGCGHIJHIIGIJGIIIJJHHHFEEBDFEECCCD#
@6SI
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BBBFFFFFHHHHHJJJJJFGIJHIJJJJJHHIJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDDDDDDDDDDD
@6SJ
GTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTN
+
@@@DBDDDH?CFBBGIIBFFBCGDHIFEEHHFFEHEBBBDDH<D?GFCFGG?BFGHAEGGIACFHEIICEHE?<?BBACDA>A?A?CCC>@ACBBBB>9?#
@6SK
CTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJ?HHIIJJJJIIJJJJJJJJJJDHIIJIJJHHFDDDDCEDDDDDDDEDDDDDBDDDDDDD#
@6SL
CGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFFHFHHIJJJJIJJJJJJJIHIJJJIJJJJJIIGIJIIJJGIIEIGHIJIIIJGIIJIJHFHFFFFF@CEECEDCDDDDDDDDDDDDDCDD
@6SM
CTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCN
+
@C@F?DDDHHGHABHIIECHIIGGGGGIIIIGGEGG:BFAEDFCHBBAHFDHGGCHEGIGIGBAGIDHHHGF;B>9=B9?CDCCADDBAC:>?4<?9ACD#
@6SN
TGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIIJJJJHIJJJJHHHH?DEFFFFEEEED?BDDD
@6SO
GCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
@@@DDAAADA>FFI>?FHI>IBHIGGIIIBH?G;C@FGEH@DA?FGHHG:<(7/@;;3?EFE=A6;6?CBCB?;@CB9:A?CCCCCCCCA4?84:CCC
@6SP
AATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATN
+
CCCFFFFFGHHGHIJIJJJJJJJJJJIJJJJJJIJIIJJIJJIJJIGGIJJJHHHGHHHFFFFEFDEEEECDDDDDDCCDDDD<CCDEEDDDDBCCEDDD#
@6SQ
CGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGG
+
@C@FFDDDFHHHHIGGGGFDH>@FBFGGCHFHBEEHFF;<8?BBBC@BBBBBCBBBCCCCCBCC@DCCCDEDCCCCC?@A?<B9CACCCCCCCBB8?B@
@6SR
GGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGC
+
CCCFFFFDFGFHHIGJIIJHIIHGJJJJIIFGJJIIJIJJJGIJJJJIIHIIIIGIIJGHFFFDECEDDDDDDDDDDDDDDDDEEDDCDCDD@BDDBBD
@6SS
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHJJJJJJIJJJJJCGGFIIIIHJJJHJJJJJJJJIJJJJJJJJHHFFFFFEEEEEEDDDDDDDDDEEFEDDDDDDCDDDDDDDDDA
@6ST
TAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTG
+
CCCFFFFFHGDHHJHIJJIJJIFFFGIJJJI9EHGIJJFIHIJJJIJJJJJJJJJJJIJJJJJJJGHHHGHFFFFDEEEDEEDCDCDDDDDCCDDDD<?
@6SU
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
@@C?DFFDDDDDFIIBGEGIIIIIHAEHIIGG0?FH?DHGIGEFGG;DFBEIHHFFEFFEEFEECCECCCCCDDCCCCC@CDCDDDDCDDDCCCDDEDDD#
@6SV
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
@@@DDADDFD;DD:CCCBD8:ECCFDCGCFHHGG>CGDDB?D@A455=;EEIICA=;>BECBB9;@@@CC3(:<:::>>:@83>AA@C>?BBBCCC:@@C#
@6SW
CATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTC
+
@@@FFFDFDBFFDIIGGECHDIDHHIBHGF@@DFHGGEGEEFGGGIG4:?@F?GAFFBGGICBDDGHCA4CGCBFGHEG>@FH@DD=DD>E>CAA7?7@
@6SX
TGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATN
+
C@CFFFFFHHHHHJJJGHIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJIHJJHHHHHHFFFFFFEDDE#
@6SY
CTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCN
+
==??=2=4,22ABEEA<EEB1<C?F?:9AF@CF>BED98DDCDEEIEDDDICEE?D<DB<?8)=CE>;CCC@CEC4@7=7??DD@DDEADAA>AA>;>;5#
@6SZ
ATCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTN
+
@CCFFFFFHHHHHJJJJJIJJIJJJJJJJJJJJHJJJJJJJJJJJIJHHHHHHFFDEDEEDDDDDDDDDDDDDDDEEDDDDBDDDCDDDCDDDDDDDCCD#
@6T0
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGN
+
@@CFFFFFHFFFH<EGEGIHGGIICHIIIIIGIIIHGIIIGIIIDGHIIIGIGIGCDGH=@;F=FEE-?EEDDFFE>A;?C>C>;@CCDDDDDBCDDDDD#
@6T1
GTGGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@?@D?D?DHBCAFEADA:<@D?:CFHIGEDG@;???FAFGDIIIGCGEHIG@EEEFHEDEEEE;>CAAC;A>>;@CA>@A>ADCCCCCC@CBBBB5<CC
@6T2
TGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGN
+
@@BDFFDDHHHHHJIJJJJJJIJGJIJIJIIIGDHIJIJJJIIIHGGIIJJJJJIJJJJIIIGHJJIFGGIJGHJIGGHIIGHHGHH;BEEFDEEEBEED#
@6T3
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJGHIIJJJJJJJJJJJJJJJHHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDEEEEDDDDDD
@6T4
CCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACAC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJFHIJIJIJIJJJJJJJJJGJJJJJJJHHHHHFFFFFFEEEEDEDDDDDDDDDDDDDDDDDCDDDDDDBD?
@6T5
GAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCN
+
CCCFDDFFGHHDDGIIGGGGDHDCAFGEEBGICIDGEEHEGGHIAFEHIICCCGIIGGIDCFEGGGIGHICHGHGFFF39>=8@ACDCC;ABBBBBBD@@#
@6T6
GGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
CCCFFFFFHHHFFIJJJHGIIJJJJIHIIJJJJJJJIJJIHCHIIIJIGJJJJJGIIHHHHHFFF;CCEEEEECDCDDDDDDDBBCDDCDDDDDDDCCC
@6T7
AACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGN
+
CCCFFDFFHHGHHJJIJJJJJJJJJJJJIJJFHIIJJJHHJIIIJJJJJIIHIJJIJIIJJJJJHIJJHHHHFHHFFFFFFDDEDDDDDDDEEDDDDDDD#
@6T8
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGGN
+
::?D+B=ADHFCF88EH::CB?DB<?):::86DD?G>FCEGHC;3@C@G@C=7?AEECC@DC:?6;@(;;;@5;;>;B(55@>C:,55?B>?A@((++((#
@6T9
GTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCN
+
@@@FFFDFHGGHGCGGGFJGIIIHIIJHHI@HEBHIIGIIGIIIIIJGGIJIJJJIFGIIIIIJJHHHHFFFFFFCDCE=BBDDDDDDCCDEDDDDEDED#
@6TA
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIIIJJJJJJJJJHHJJJIJIJJJIJJJHHHHHHFFFFDDDDBCCCCCCDADDDDDC#
@6TB
CATAAACACCCATGCTACTGGGGTTGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHGHJJJIIIIIJJJJJJJJJGHIJJJJJJJJIIIIGIJJIIJIIIJHHHHHGFFFFFFEEDCEDDDDFDCDDDDDDDDDDDDCDB8@CD
@6TC
GCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGN
+
CCCFFFFFHHHFHIJJJJJJIIJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIIJJJJHHHHHFFFFFFD#
@6TD
CTCTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCCTCCCTTTCTATAGTAGCTCGCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGN
+
@@?DDDDAFFDHHEHGIIIGIGIGIIIIJJEHGHIIGGIEGGHGIJFHGIIJAGHGGEHFFFDDEEEEEAC>>CCBBDBDDDDDBBDDDDEDDCDDDDDC#
@6TE
GGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATN
+
@@@BDDDDFHGGGHIEHIIIJGIIIIHGHGHIHEHIGIEGIGIIIIJGGGIJIEIEGFCCHGHGIHHHHHHFF3?@BCEEECCDDDD@CCDDDCCCACCD#
@6TF
CGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTN
+
@@@DDDDDFDHD?FGHIIIAEHIIIIBEIGHIIGHDAFCIGDHG>BFHHHEHEIIIIGGCG7==@CAGCDEHHEEHDEEECC;;@BCCC@BCCC>ACCCC#
@6TG
CCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGT
+
??@B+=DDB2=DFEDGBEFI@EFEFFFE@B@FCBDFFG*0?GFEE<=CFF3=55@EC7=35;;?>>:8;??<A5:@>ABBB?:@A3@@++25?93<<+
@6TH
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
:??DB;A2:CDDA:E32A:F:FFB?<A@2+A?E9C11:DD8D0?:A-)..>84/.(..?A?(;?(;6;>-(;53>:A::>355(55554:(4(44(>((+#
@6TI
GCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGC
+
CCCFFFFFHHHHGJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJFJJJJIIJJDHIIJHHHHHHFFFFDABDDEEDDDDBDDDDDDDDDDDDBDDD
@6TJ
TTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATN
+
@CCFDDFFHHFHHEIJJIJJJIIGGGHHGIJGJIJGIJJGIJJCHGHGCGGHGHJJIEIGDHGEGGIIJJJJJIIIGHGGIDEGIEHFHHEFFFBEEDCE#
@6TK
AAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACN
+
CCCFFFFFHHHHHJJJJJJJJJIIJJHJJJJJJJJJJJJIJJJIIJJJJJJJJIIIIHHIJJJJIJJJIIJIJIIJGIJIJIIHHHHHHFFFFFFFEEDD#
@6TL
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGGGN
+
@@@7A6=DAFFCFEGC3<?EAA<B3;8??DDEGFFFBC20?;?F>ADFBFAAFEFC9@@EE6.=:;;@B@;?:;>>BCBAB@A5>>@BABBB??BBB?&5#
@6TM
TTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCN
+
CCCFFFFFHFHFGHIIJJHHIJFEGIJJJJJJIIIJFIJJJJIIIJIJBCEHIIIJGHHCGHEHABBBEEACECEDCEDDCCBDCDDDACDDD@CDCCDD#
@6TN
GGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJIIIJJJJJJJJJJJJJJJJJJIJJJHIJIJJJJJJJJJJJJIJJJJJJJHFEHHHFDFFFDEEEEEDEFEE#
@6TO
CCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGGG
+
@<@DDBD?ADAAAE9B9<:CE9EFCDDF@FBFIF3:66;@A';;=>B?B855:<:>3:@B@B@:(587595805@9>@<9<&59<5:@@BB@)08?B(0
@6TP
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJDDDDDDDDCDCCDDEEEEDDDDCCDDBDDDDDDDDDEDDDDDDDDDDDEDDDDDDDDDDDDDCDDDDACCD
@6TQ
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGA
+
?@@D:ABDFDFFFI4E3EFHEHHFFIFCGIFIIFDFGDIIIIFIIDEEFDFIEFFEE@7;;?::@:?4?B>B@BABB>@ABB?8?>@?B@BBBEBBAB
@6TR
CTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATN
+
CCCFFFFFHHHHHJIGHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJHHGHHHFFFDDDDDDDE#
@6TS
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
CCCFFFFFHHGHHJIIIIIIJGIJJJJJJIJIHHHHJJJIJIJIIIFGHJJIIIIIIIJJJIJJJIJJGHGHGFFEECECCCDBBDDDDDDD<CCD>CDD#
@6TT
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
CCCFFFFFHHHHGJJJIIIJJHIJJCHHIIIJJ?DGIGIJJIIJBFGIJHIJIJIJGJJHHHHHFF=ACEEEDDDDBACDDDDDDDDDDDDCDCDCDDEC#
@6TU
GGTAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
@@:DDEEFGFHFHIGIIJJJIJJDGHIGIGGIGEHJIGIIIIJIIIIIJIJIGEIIAEHHGHGFFEEFEEEDCECCC@CCC@CDDCBDD?CDDDDDDCD
@6TV
CCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTN
+
CCCFFFFFDDHHFGIJEGGIBBGGHCHGGHIJIIJIIJI@?@DB@GGGBFFGCHGIHFC??B?>CCDCADCCDDB<>>B?CC@DCDDCC>@ACCDDCCCC#
@6TW
AGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJIJIIJJJIIIIJJJJJJJJHJJJJJJJJJHHHHHFFFFFDDDDDDDD
@6TX
TGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCN
+
CCCFFFFFGGHHHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJGIJIGHIIIIJJJJIJJJJJJIJJJJJJJJJJJGIJHHHHHEEFFFFFEEEEEEED#
@6TY
CCCAGCCCCACTGAGGCAAGGGCCCCCGTCCCCTGTCACCAACAGTGAGCTGGGGAAAGCAGAGAGCATCAGAGGGTTGTCTGGAGAGAATACTGAAGGCN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJCHIJJHHHHFFFDDEEEDDDDDDDDDDDDDD?BDDDDDDDDDDDDDCDDEDDDDD#
@6TZ
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
@@CFFDDFHHHHHIIJEHGEHIIJIJHIJIJJIIJJJJIJIIJJIIJIJJJJJIIJJIJIEHGFF8>B>CDDDDDDDDDBDDDDDDCDDDDDDDDBBDDC#
@6U0
GTCCCCTGTCACCAACAGTGAGCTGGGGAAAGCAGAGAGCATCAGAGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGCGGCTCCCTGN
+
@@<D;?DBC?B>?<E?AAE:<<;<ADFDHDBC@?CFCH;?FB909D?FB;BA8@FE@CEHCAEAD;;;B3;;;@AB@A>>??38?A<59((595<B@@33#
@6U1
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATN
+
@@@FFFFFHHGHFIIGIJJIIIEGIIIIIEAGIIIGEFDGHIJJJIGIIEEEEGCHHHEFDDDCEAACCDDDDDDDDB8?@BCCCCACDDDDCACDDDDD#
@6U2
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCN
+
@@@FFFFFFDDHHGFHIHCHICGCHIIIIDDBBCDDDCC>?A8BBADCD@B9>CBBDB@BD8>>@CDCC>CC@CCCDEC>@ABB9<<?CCBCCC@C44?B#
@6U3
GTCCCGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCTGTGCATCCCTCTGGGGCTATCN
+
CC@FFFFFAADFDHGBAFHIGIAGIJGECFIGEDGIGIGJFIIIJIDGG@EHIGGII>>BF@CDCD@ACDCCAACDDDDCACADDDDBCCDCDCDBDDDC#
@6U4
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCFFDDDFHHGFCGEHGDE@GGBGFHFHIGI1?FGFHGDAGG4=FHGEGCHEHHGFBDFDBCCEEEDDDDCCBDDDDCCDDCCCDDCDCDDDCDDB@CC#
@6U5
TGTTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGN
+
<@@DDFFFHFFFBBBGIHHIGHGIIIIJIGHBEEHICHGBGHCHGGI6@AGGFFCDACAC??AA8=@B@CABDDBDBDCCDCCD?:A:4>A3@CDDDA(4#
@6U6
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFEFHHHHHJJJJJJJJJJFHIJHIJJ:DHIHIJJJJJBGHJJHIJJJJJJJJJJJJHHHDDFFEEEDEEDCDDDDDDDDDDDDDDDDEDEEEDDD#
@6U7
GTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGG
+
CCCFFFFFHHHHHJJJJJJJJJJHIJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJHHHFFFFFEE
@6U8
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
CCCFFFFFHHHHHJJGIIJJJJJIIFHIJJIJ?FHIHIJJJJJHHJJJJJIJHHHHHFFFFFEDEEEDDDDDDDDDDDDDDCDDDDDDDDDDDDDDEDDD#
@6U9
CCGCTCGGTTGCCCATAGGTGTTCTGCTGAGGGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGAAGGATGGAGGTGN
+
;?;DDD??FFA;<E@G>A2+A1CGCGA4C*:):):;9*?D<B>F*98C9)=<C=FC>88'5=67;;@;;@;@3(>@5>?5558A:2;&(22++4<+8<(+#
@6UA
CTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACN
+
CCCFFFFFFHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJHHFFFFEDD=ADDDDDDDDDDDDDDDDDDDDDBDBDCCDCD#
@6UB
CAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJEHIJJJIFHJJIIJJJJJJJJJHIHIJIJIJIJHJJJIJJJJJJJHHHHFFFFFFDACDDDBBDDDDEDDDDDD#
@6UC
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCN
+
?8=??D=AFDHA?FGBF;FFHIGCHDEGI<<G?)??DFBHIE6DGHG<C>AHGHFCA=?CBBC>AACAACC<@999BBCCCACBB00?B>A>:8+:>3>A#
@6UD
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJHJJJJIJJJJJJJJJHHBCDD>CDDEDDCDDDDDDDBDDDDDDDDD#
@6UE
GACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCAACATAGGCATCATTTCCAG
+
CCCFFFD?FFHFHIIJIEHHGIJIIHIIJJJJJJJJJJJJJIJJJJJGIJJBGHIIIIIIIIJGGHGIJJJIJ
@6UF
GTTTAACACATCAAGGTTGGAATGAGCTGGATAAGGCTGATGACCAAGAGTTAAAATCTCCCAAATCAGAATTCCAAAAGACCAT
+
@?@FFFFFHBDHFHJIAEFGGEHHIEGIJJGIIGGEHIIJJJIIIJGGEHGIHIIIJGGGIGIJHGIHGGGHHFHHHHFFFEFEE
@6UG
GCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTTTCTCCAGGACCCAGGGAAATGTTGCCCCTGGAGCCCAGTCCCTGGCAGCCTN
+
@@?DA=D;?;DD??E9EAHEH?BFHFA?E8:?BD@AHIB3BF>D>D?8?F>D=8=8=;=DE=E;B5;??;7?@ACC?@@5;==?@B?,:@C>>8<?BBBC#
@6UH
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
@@@BDDDDH>DHHCCEEHIAFEHCHGGIGIIIHHFCGHIGICGGEGGHIIDGHCDDF@GICFGEFGCDGHEHED7@DDECCECECBCC>CCAB55>C::
@6UI
GCTGCGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGN
+
@@@FFFFFDFHHHGIHIJIIIIHJJJIJJJJJIHGIIJIJJJGHIFHEAFHIIIHIJGJHHHHHEF?DFEEEEEEDCDDDDDCDDDDCDDDDDBDDDDDD#
@6UJ
GTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAA
+
@@@FFFDEBFFHHGBH2ABEEGIFHIIGIIGCEGGHGHIIGHIIIIEAGHIIHIHGIICHE?DFEHDFHGH@HGIGIEGCGB@DEHEHFEDDFFFFBCA
@6UK
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJHIJJJHIJJHIJJJHJJJJJJJJJIJJJIJJJJJJJJJJJJJIHHHHHHFFFEEEDCDDDDDDDEDEDDDDDDDDDDDDD
@6UL
TTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATC
+
CCCFFFFFHHHHHJJHJJJJJJJJJJJJJJJJJJJJJJJJJJGHIJIIJJIJJJJJJJJIJJJJJJJJIJJJJJJJIJJJHHHEEFFFFFFEEEEEE
@6UM
TAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTN
+
@@@DFFDFBDFHFIIGHCA<CB>FHGCGHFGHIEFH>?@?BDGHGGIIIIGFGGBHGHCDHCDHGGECCC;=FEHGII>EC>EE@BD???AEDEEEECCD#
@6UN
CTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCN
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJIJJJJIJIJGIIJIJJJJJJIIGHIJHHHHHFFFDDEDDEEEDDDD#
@6UO
GTTTTTTTCAGCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTN
+
CCCFFFFFHHHHHJJJJJJJJJIGHGIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIGJGJJIJHHHHFFDFFDEEEEFEEDDDDDDEDDCFDD#
@6UP
GGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTCTCAACGN
+
@<@DFF@DFHHFHEEHIFHEHGGGGGIJGIGIGJJJGIJJJEGHHHGH7AEHFHFFFFFCABADDDDBDDDEDDDDDDDDDDDDDDCDDDDDDCDCDDDD#
@6UQ
CTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGN
+
CCCFFFFFHHHGHJGHIIJIIJJJIHIJJJJJJJJJJJJJJIJJJJIJJJJIJJJJJIIJJJJIJJJJHHFHFFFFDDEEDDDDDDDDDDDDDDDECDDD#
@6UR
GTGAAAAAGTGCCTTGAATGTAATTTGCGCAGAGCGCAGGCCTACCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAA
+
CCCFFFFFHHHHHJJJIJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJIJHIJJJJJJJHHHHHFFFFFFCDEEEDDDDDDDDDDDDDDDDABDDDDDD
@6US
GACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGGGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGGGTATTTGGAGAGGTTGTGAAGAGGGCTN
+
@<?BDB>DBFBBFI:E@>FHAF@F:=BA>FCDCEGG@):D@B6(8AC>9A9>3@>@@CA@>C(8+3:C@34>(3(44:@DC39(8?:1<5?::::??9&(#
@6UT
CTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGCAGGTGCGN
+
CC@FFFFFFHHHBHIJJIJIIIGGIJJJJJJIJJJJHIJIJJJJJJJJJIJJJIJJIJJJJIGJJJJIJHHHHHHFFFFFFEDEEDDDDDDDBDDD8ACD#
@6UU
CATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTN
+
@@@BDEDDDHHGHGGECGHIIAGG@?EGFGEEHGEHIIIGHGGG<FFGIIEEGIBFBGGFG@FGCGGGI@@EHHECCEDDC@CECECCCCBBCCCDCDCD#
@6UV
AACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCGGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTN
+
CCCFFFFFHHHHHJJJJJGHIIJJJJJJJJJJJJJJJJJJJJJJ?FHIJJJJJJJJJJ'=EFFFFDEDDBDDDDDDDDDDDDDDDDACCDEDDDCDDDDD#
@6UW
CAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGN
+
CCCFFFFFHGHGHIJDHIIJJJJJGGIJIIJIIHIJJFHIJIIJJJJJJIIJJIIIHFFFFFFFEDEEEDDDDDDDDDDFDEDDDDCBCCCDDDCCDDDD#
@6UX
TGTTAACAAATTGTACGAACACAAGACTTAAGAAATAAGAGCAGATGCTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTN
+
CCCFFFFFHHHHHHHJJJIIGGGJHIIJJJJJJJIIIIGIIJJJJJGIIJJIJJJIJJJGHIIJIIIJIHHHHHFFFDFEEEEDEEDDDCDEDDDDBDDD#
@6UY
ATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
@@@DDDDD;D4F<EFBB<ADEAFCB9FEFBF>DFFFECGDFGEFBFCCDCBFF9FFE>FCDEE>CEF:AE7;;?DBDACCCCAA@>@A>BBBB<?(8558#
@6UZ
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTA
+
BBCFDDFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHHHHHFFFFFEEEDEDDDDDDDDDDDDDDEDDDD5@DD9C
@6V0
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
CCCFFFFFHGHHHJJJJJJJJJJHGIJJIJJJIIIIIIJIJJJJJIGHFHHIJJJJJIJIJJJJJJIJJJJJHHFFDCECEDECDDDDDDDDDD9CCD
@6V1
CCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTN
+
@;?DDBBBB?CCDF?<A<C<EB<:A?+2AEF@?E>GC>@?F6:D?DD??D?/9;F@;@FEDCCDBEF;)7;373@@A?9/;11,5:3(55,,(:55@A43#
@6V2
GGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTN
+
BCBDFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJDDDDDDDDDD@CDDDEEEDDDDCDDDDDDDDDDDDDEDDDDDDCD#
@6V3
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFDEHHHHHIIJIJJJJJIFHHJHHJJDHGIIJJJJIIBFHIJHIIJJJIJJJIJJJHHHBDEFEEDDEED@CDDDDDDDDDDDDDDDEDEEEDDD#
@6V4
GCCTTCCCCAAAGCATGGAGGATTTTGTAGATCTCCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTAC
+
@???DD?B?:?A<:AFGAFBGGIEIA?G>F@DBF>?*9?<B>GBDFFEI<?FFA>FFFI=5=CEFAFFE@;;5?;;?35;?3@B>>A:5?592
@6V5
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
CCCFFFFFHHHHHJIJIHHJIIJIIJIJFGIJJJJJJIJJJJJJJIIJJJIJJJJJJIGHHFHHFFFEEEEEEDDDD8?B<CCDCCDDDDDDDDDDDDDD#
@6V6
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
CCCFFFFFHGGGHIJJJGIJJJJJJJIJJJIJJJIJIJJJJJJJJJJIJJJJIIJJJIJJJJJ;EHEBEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6V7
GTCCGTAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
BBCFFFFFHHHHGJJJJJJJJJJJJJJGGHHJJJJJJJJJJHHJJJJJIJJIJJJJJJIJJIJHIJHHHFDECEEDEEDDDDDDDDDCDDD@CDD2?@D
@6V8
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCC
+
@@@DDEDFFBDHHIIIHGIEGGGGGGGGIJJIIIIGIJJIIIIGIHIBGGGIGIIGECBDDFDCCEEDCBB;??CCCDDCDC>@ABBBBBCCCDDDC
@6V9
CTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGN
+
@@?DDDADBBDFF:CFBDDDHIIIGEHGEGH)0?8?D<<?DDBF@CC@C;DAA@CCACE=9B>B?66;>5-55>CC@>9:>>C;ADCC@CC:A:3?BCC@#
@6VA
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
@@@FDEFFHHHDHEGIIJJJJFIJJJIJDDDDDDDDDDACCCDEEEDDAA9ACD?BD?DDDDDDEDDDC@CCDDCDDCDDCDD@B@CCDDDCCDD@CCB
@6VB
GGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJIJHIJJJJJJJJGIJCHGBEFFEEEDEEDDDDDDDDDDD?CD>B:@CCD#
@6VC
ATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATN
+
CCCFFFFFGHHHHJJJJJJJJJJJJIJIJJIIJIJJIJJIIIJJJJJIJJJJJJJJJJJJJIJJJJJEIIIHHHHFFFFFEEEDEEEEDDEDDDDDDDDD#
@6VD
GGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGACAGTACAGCTTCCCTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTN
+
CCCFFFFFHFHHHJHIGIJIJJJJJIJJIIJJJJJJJGIJIIJIJJJJJJ@GIHGFFFCEEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDD?BBDDDB#
@6VE
GACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCN
+
CCCFFEFFHHHHHJCGHFIIIJJJJJJJJJJJHIIJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJHHFDDDDDDDDDDACDDDEEEDDDD@CDDBDDD#
@6VF
GGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATATCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTN
+
1?=++A+B?D?DDEDEACEF<A?38)1:;C<B9*1**9?3?B99?<9?8DDD@B4B88@)8@ACD)=4=A)=AAD/,;@>3-;5(-(51;>>>A::=:3+#
@6VG
CTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTN
+
<@@DDDDD:FDBHGHGI>HBFHIGIIGHGDGGGGHCGHE?:BDGHD@FGHG?DHIICG>G@HHG@@EGG>;CCE;;8;5;>>>CCCCC>?5>CCCAC>CC#
@6VH
CTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATN
+
@@CDFFBDGHGHFHIIIIGGGIIEGIGIJJJJJIIJGGGJJJIIEGGEGIGGI@BCHIJIGAFHEHG7@@AEE?CEAD;@BBEFEDDAADDDDCCCCCCD#
@6VI
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
@@@DDDFDDHHFHIIIHG>EFDHIGCH?F?GCHGIIIGIEHDGHIGGIGFHI<FFDGHIEGH;==AG=;E?BEF@A@ABACCD>;@C<>@B@CBB(38?
@6VJ
TGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGN
+
@@=BBDDDFFDHH:CGH=DA9?;;?='86;@:)0<A8>8>A<5<8:00:B@055(3:@C:3@>ACC@>4>9955>BC>:9A?>+(49ABB<<8>4::>4<#
@6VK
TTTCTGTTCTCAGCCTGTCCTTTTCTTTTTGAAGACTGTCAACTTTTTCTTTTAGCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCN
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJJJJJJJJJJJIIJIIJJJJJJJJJJJJJJJJJJJJIJJJJJJJJGHHHHHHFFFFFFFEEDEEEEDDDCDED#
@6VL
CTGGGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGGGN
+
@@@FFF@DHDHHDHH?EGGIBHGIGGGGGIIIIIEDFHDGGGGIFHIIIIGGIGIGGEGEAG=CHFHHFF>CDC3>@C>@CA;>AACCCCCBCCCCB@&0#
@6VM
CTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTC
+
CCCFFFFFHHHHGJJJIIIJIJHIGJIIJIIIIIIIJJEGIIIIIHIJJJJJJJJJIFHIJJIIIJJJJIJHEHGCDFFFEEEEDEDCCDEDDDDDDDD
@6VN
CTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTA
+
@@@DDDDABBH?FHHEHHBDBHI9CD@GHGE@EFGEBEFFEIBHAGCGGHIC>GHEHEH@>D8;@CG@FDCGGE;D=3AAEA;BE;;>;(;>@CCD:>C
@6VO
GTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCN
+
@??DBDDDFDFHFIIBGHGGGHIHICHHHGHGGHFHGCGEHGHEDDGGIIIIIIIHIGIGGBFB8@@FHEHGIGHEFAAAB?@@BDDCC@AA>@8A?@DC#
@6VP
GTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGACCTCTGCAGCTN
+
@?@DDDEDHFHHHEGAE@AHHIIGGHIBHFBGA@FHIIIG<@GAGDBB@G<CFEBCHEECEFBDB=BDD?<C>>CA9229+8??B?>9A(2>C:::3+>A#
@6VQ
TTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTN
+
CC@FFFFFHHHHFHIJIJJJJIJIJJIJJJJIJJIIJJIJJFHHGHGGGGHJJJHHIJFGHIHHJJ-=CDCDEFCED;ACDDCDCDDDDBDDDDCDDDD9#
@6VR
CATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGG
+
@C@FFFAEHDDHHIIGIJGGIIICCGHAEEEHEGAFHI9?GFGHJG>FGIBEBFHIJJIACFCFA>6AECEA.=@DFF=6>CCECED@@>5;@A5:5:<
@6VS
GAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJHIIJJJJJJIJJJJJJJIJJJJJJIJJJJJIJJJJIJJJ=CHHGHFFFFFFFCEDDDDDDDDDDDDDD@CCDDD#
@6VT
GCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACN
+
@CCDFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIHHH?BDDDDDDDDDDDDDDDDDDDDDDCDDEEEDEEEDDDDDDDDBDDDDDDDDDDDDDDBDDDDD#
@6VU
GGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CCCFFFFFHHHHHJJCGHJGIJIJJJFHEIIIJJJJIJJJJJJJIJJJJJJJJGHHHHFFFFFFEEEEDEDDDDDDDDDEDDDCDDDDDDDBDDDDDD
@6VV
AATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAA
+
CCCFFDDFFFCDFHIJJJJJJJFIIJJIIJJGFIIJIIIIJJJJJJIDFIIJGJI8>77@EHHGHFB?ACDDDDDDDDBDCCDDA??ACDDDDCEEEED
@6VW
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
CCCFFDEFHHHHHIJIJJJJIJJJIJJJJJJJJJJIJJIJJIJJJIJJJJJIJJJJJJIJJJJJJ@FHGIGHEHHHFFFFFFFEEE>CBDBDDDDDDD5<#
@6VX
CTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGN
+
<@@BDDDD:DD;DBECF3+9CEEBFFC?BDFF<DBFFF0B2C@BCCF=FCEABDC6?B-?ABA+:?<@B4>A?@B59?AB>A>BD9>A:>@4>@BBB?BB#
@6VY
CGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATN
+
@C@FFFFFHHHHGJJJJJIJJJJJJJJJJJJJJJJIJJIIJJJJJJJGHHIJHJJJIJJJIIIHHHHFFFFFEECEEDDDDCEDDDDDDDDDDDCCDDDD#
@6VZ
TGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAG
+
CCCFFFFFHHHHHJJJJJJJFHFHHHFIGJJIJHIIJJJJJJDHGGIIJJJII@GIIJJJHHFFFFFDDDDBDDDDDDDDDDDDDD
@6W0
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
CCCFFFFFHHHHHJJJJJJIJJJJJCGHIFHJJJJJHIJJJIJJJJJJJJJJHHHHHHFFFFFCEEEEDDDDDDDDEDDDDDDDDDDDDEDDDDDDDDDD#
@6W1
GGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATC
+
CCCFFDEFHHHHGJJJJJJJIJGIHGGGHIHIIJBGCGHIEIJDHDFHFGGGGIIJJIIIJIIJJIIHHFFFCECEDEEDDDCDDDDEDDCDDDDDADD
@6W2
CTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGN
+
CCCFFFFFHHHHHJJJJJJJJHHJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIIJJJEHIJJJHHHH=BBDFFFEDDDDDDDDEDEDFEED#
@6W3
ATCAAGTTTCAAAGGGGTTGCAGGAGACAGGCCCTGAGACCCATTCATCAGCTGTGTGTTCTGAATCTGCATCTCCTCAGCCTCAAACTCCATGAACCTTN
+
?==DBEBBFFHDDHIGEGHAF@BGG=EHCIGHGGIIIEEHIGCF<FBFGCGGEH;C==@@DDGACCCCA>BCCD@DCCCCACDDCCCCDCAA>>ACDDDD#
@6W4
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJFFHHIJJJJJJJJJJJJJJJJJJJJJJJJIHHHFFFFFFEEEEEEDDDDDDDEEEEDDDDDDDDDDDDDDDDDDDD#
@6W5
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
CCCFFFDFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJCGIHHHHHHFFFFFFFEEEEECDDDDDDDDDDD>#
@6W6
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJIIJJJIIJJJIJJJJJGIJJJJJJJJJJIIJIJIHHHHHHHFFFFFFFDDEEDDDDDDDDDEDDDDDDD
@6W7
CTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTN
+
CCCFFFFFHHHFHIJJJJJJJJJJJJJJJJJIJIIIJJJJJJJGIIJIIJJJJJJJJJJJIJHIIIJJJJICGIJJJJJJIIGIIHGGHHDFFFDFFEEE#
@6W8
GCACCACTGTACTCCAGCCTCAGCCCCAAGAGTGAAACTCCATCTCAAGAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACN
+
@@@FDDFFDHFBDHIGE@GIJIGEGIGGIEHHGGCIGIIIJJJJJIIGHJIIIJIIJIJGHGIIIFHHGFDDDBDDDDDDDDD@DBDADDDDCCDDD?AA#
@6W9
GCTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTGGGGGTCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCAC
+
;<@D??DDDA;ABG?CGBG@?C?CC;FEHFEIACDFG?;??FAFIIIIGEH;DA;DGCHEE?C??BECC655;>CC;;@@:CAACAAC>::>:9??@BB
@6WA
GTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTN
+
??<DBDDDA+<CA@E:;E@DCB@BDEE>DEID=D?;;0??BD(?;BCBECD=AE=A;C@AC<1?@@?AA@@AE>>AB>>A5;>A>A>ADDA>A?A???19#
@6WB
GCCTTCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCC
+
?@BFFFFFGHGHHIIJJGGIJIJJJJJIJIJJJIIIJGHHGIIJJGIGIGIIHHHHHHHFFDDCCDCDDDDDCCDDDDDDDDDDDDDDCDDDDDDDDDD
@6WC
TGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATCTTCN
+
@@CFFFFDFHFHHIJJJJJJGHIIJIJJIIIJJIGIDGHIIFIICFGGIJCHIJJJGGHGHHFFFDDDDDCDDDDDDD>BDDDDDDDDDDDDCCDDDDEE#
@6WD
GCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGN
+
C@CFFFFFHBDFHIIIIIGIIGGGGIJGGIIJGEEHGIGJBDHIIIIGGCEE>FCGEIEHHCHGJIG@=B;;CFDDCA?8;<?BCCDCDEDDDD:>A:?B#
@6WE
GGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGAC
+
@CCFFFFFHHGGHIJIJIJIJJJEHJIIIIIIIIEGGJJJJII:@DFGIFGGHGIHGIIGHGHHHHH=BDFFFFFECEEDDBCCCCCDCCDDDDDDDB
@6WF
CGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJGIJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJGHHHFFFFEDCEEEDDDDDDDDDDDDDDDDDED#
@6WG
GCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
@@@DFFD;FHHHGCFHHHIJIJJIIHIICFHDGGIIIHIIJJJJIGHIIIIGIJIJJIJIGIIHHHFFEFEDAEEEDDDCDDDDDBDDCCDDDD>ACDDD#
@6WH
GTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGN
+
?@@BBDD8FDAC:CCF:C:CHHIE@:4<CFDEF8CC@@@CDFEAC97===@<5(;)7;??B'3,>AB>:(:5;>A<8?BBBA:A(5599:@>::<(81?A#
@6WI
CCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAA
+
CCCFFFFFHHHGHIGIJJIJJJJJJJIJIIIJIJIIIJIJJJJJJJJJJJIJJIJJJJJIJIJJJJJJJIJJIIJJIJHHHHFFFFFFEEACBBDDDDD
@6WJ
GCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCN
+
CCCFFFFFFHHFHJJJJIJIJJGIJJIHIJJIIJGEIJJJJJJEHIJJJJJJJJJGJGJHHGHFFFFFEEECECDD9?BBDDDDDDDDDDDDDDDDDDDD#
@6WK
AGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CCCFFFFFHHHHGJJJEFIJHIJJJJJHIJJJJJJJJIJJJJJJJJJJJJJJJHHHHHFFFFFFEEEEEEDDDDDDDDDDEDDDDDDDDDDDDDDDDDD
@6WL
CTAGGCGTGTGCTGCTGGACATGACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGA
+
@@@DDD:@@8CFFFBBGBFF9C@4<FBEE@GCFFI@?6DEA/=;?@BBBBB?B???B>>3?ABB:@>>BBBAB@>>>AA98:9AAB::@BABAA:><<5
@6WM
ATGCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCN
+
@@@DD??DDBAAFB>@62CFF<CCB=CG>G@@FGE??FFC39)0?9*9BF;FACFDEF))6@AEB?AADDBB;;;6;>8;;@ABB::>(5>>>+4>88<?#
@6WN
GCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJFHJJJJJJJJJJJJJJJJJJIJJJJJJJIIGHHHHHFFFDDDDBDDD@BDDDDDDDDDDDDDDDDDDDDEEEDD#
@6WO
CGGGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGN
+
1=;DBAD2<<AFFCFHHEH?HDCG@FGBFHGGGEGHH<FGIGHHGEHGGFHGFHFA4=FHGH7;@>7??EH>D=9CCC@CDC;>CCCEDCCC@>A>C>A@#
@6WP
CTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIIIJJJJJJJJGIHGIGIJJJJJJJJJJJJJGHGHHHHHHHHFFFFFFFEEDDEEDDEDEEEEEEEE#
@6WQ
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
CBCFFFFFHFHHGJJIJJJIJJJJJJJJJJJJJJIJJJIIJJHIJJGHIJJHIJJJJIJJIJJHHHHHFFFFEEEEEDDDDEDDDDDDDBDDD@CDDCD
@6WR
GTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTN
+
CCCFFFFFHHHHHJIJJJJIIJIJIJIIJIIJJJFHGIHHIIGGIJIGGJJJJIIIJGIGHIIHIJJJHHGHHF?DFEFEDDEDDDDEEDDDCCDD?5<A#
@6WS
GCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGTCTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGN
+
@@@ABBDDD<73?ED;ED@@>FCBFD::1:?:9B>DCHIG>FDD??FH<CEG@<F;@F@DHIFHEEHFEDEE;;;9>'9;CC:ACC5:@>:CAA@<<<:A#
@6WT
TGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTCCATGATGN
+
CCCFFFFFHHGHHJJJIJJJJJJJJGIJGIIIJIJJJIIJJJJJIJJJJJJIIJJHHIIIJJJGIHJIIJJHHEHHFCDEFFEDDDDDDDDDEFEFDDDD#
@6WU
TTCATTTCTTGCTCCTTGAATATGTTTAATTTCTACAAAGCTTCCAGTTGTGCCCGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACT
+
@@;DDDDDFC<FDFIIB4<3C<EFFFFEE@BC?CHHIEI93?:9CD11::D@*?9@?DF@FCFF=@7@7@CDEFEF:7===AC>@@@DBA;;>;@>5
@6WV
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGN
+
CBCFFFFFHA<AAFHIJGIJJJJHHJJJJJJJJJJJIJJJJJJJJJJJJIJJJJJIJJGHHHHFFFDDDDDDDDCDCDDDDDDDDEDDDDDDDDDEDDDD#
@6WW
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
CCCFFFFFHHHDHIJJGHGIHGIJJGIIIJJJJJIIJJIEHGIJIJJJJGIIJEGIJIJIHHHHFDDBCACEDDEEDEDDBCD<@ACDDCCDDDCCDDDC#
@6WX
TGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGN
+
B@@DDFFFHHHHHJJHIJHIJHHJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJIIIIJJHHHHFDB559C@C@:?49:(++:>C>:<+:AA#
@6WY
TGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCN
+
CCCFFFDDFHHHHJJJJJJJJJJJJIJGHIJHIJJIIHIIJJJIHGGIJFHIHIJJJIIJJJJIJIJHEEFFF@CEEECDDDDDDDDDCDDDDDDDDDDD#
@6WZ
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CCCFFFEDFHGFHGHHGIGHCFGJJIJFIIJIGIIIIJJIJIGHIIIGIHHFGDDDDHIEHJGGHGEHIJ?EHD;BAA>@EBDB@?AC>C@ACCCDDBCB#
@6X0
TCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTN
+
@@@FFFFDHGFHHIGIJIJIJJEIIIIFGGHIEHGIJJJJJHJIGGJIJJJJIIJJIIJ=?BAEECD>CBBDDBDDDDCCDCCCCDBBDBBDDDD?@A>>#
@6X1
CTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCN
+
?@@FDFEFFFHAFFHIIIEEIGFICBGEFGA@GEEE:?H?BGDDHIGDFIGDBCGBGFGIGIFDDDCHCH=AAAH@7?B;A@B8ACCDCA;>BDDABB<5#
@6X2
CATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTN
+
CCCFFFFDFHHHHIJIJJIIJIJFAFHIIJJIJFJIJIJGIJIIIJJIGIGJIJJJJJJGJJGIJIJJJDGIHHHHHHFDDDFEEEEDDBDBDDCDDFCF#
@6X3
GCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAAC
+
CCCFFFFFHFFHHJJJJJJJJJIJHHIJJJJJJJJJHIHIJJJJJJJJJJGIIIIJJJJJJJJJJJJJHIJJJJJJJHHHHHFFFFFDEEEEEDDDDDD
@6X4
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
CCCFFDDFHHHHHJJJFHIHIJJGGIJJJJJJJJJJJJGJJJJIJJJIJGIIJGIIJJIGEHFFF=ABBDDDDCDDDDDDDDDDDAC>CDDDDDDBDDDD#
@6X5
ATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATA
+
CCCFFFFFHHHHHJJJJJHIIJJIJJJJJJJJJJJFHHJHIJJ?FHIIJJJJJJGHIJJHHHHHHFFFFDEEEEDDBBDDCDDDDDDCCCDDDDDDDDD
@6X6
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGN
+
CCCDFDDFHHHGHJGIGFHIHIJIJJJGDHIIIJJHHHEDFDDCDDECDDDCCDDDDDDDDDDDC@CDDDDDDDDBDDDDDCDDDDDDDDDDDDDDDDDC#
@6X7
GTTTATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAA
+
??@BDDD?FF;C<FA>@FFHCHG9F@>BHI<HGEIGGGEFFCGEHIGIEIIIEBHEHG@<FFEH:4BAGCHGIGCAE4@DC;?AEEECDDEBB?;>@CC
@6X8
GGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAAGTGTAGGTGCTGTCACATTCAACATTTTCACTGN
+
CCCFFFFFHHHHHJHIJIJFHIJJJJJJJHJJIJJJJJJJIJJJJJJJJJJJJJJJJJJIJJIJJIJJHIGIJIHHHHHHFFFFFFFEEECEEEEEDDDD#
@6X9
CCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCN
+
CCCFFFFFHHHHHJJJHIJJJJJJJJJJJJFHHIJJIJJJIJJIJJJJJJJJJIJIIJJIIIJJIIGJIIJIIJJHHEHFFEFF@DDCDDDCCDDCDDDD#
@6XA
CCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTN
+
@BCFDFFFGHHHHJJHHJJJJJJJJJJJJJJIJJJJJJIJJJJJJIJJJJJJJJIJJJJJIIHHHGHHFFFFFEEEEEEDDDDBDDDDDDDDDDDCEEDE#
@6XB
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
@@@BDDADFHB8DD9DDEHBFEHCECGHHIE:?DEF@DGB>FFHFGICHGECHEH@ECHAGHCE?<BBCCCCCCB;@ACCC@BB<?CAC@@@@@>ACCC>#
@6XC
TTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCN
+
CCCFFFFFHHHFHJJJJJJJJJJJJJJJIJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJ:@EAEEEECDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6XD
GTCGGGCTGAGGTTGTAGCACTCGGCCAGGAAGACCTTTCCAAAGGCTCCCTCACCCAGTTCTCGCTTCAGCACGATGTCTCTCCTCTTAATGTGCTGC
+
CCCFFFFFHHHHHHIIIJJJJJJJJJJJJJJJIJJJJIJJJJJJIGIIJJJJJJJHHHHFFFFFDDDDDDDDDDDDDDDDEDDDDDDDDDEEDDEDDDD
@6XE
GGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTN
+
BBBFFFFFHHHHHJJJJJJJJJJJJJJJJJHIGHJHIJJJJJJJJJJJJJIIHIJJJJJJJJJJJJJJJJHHHHHHFFFFFFFFEEDDDDDDDDDDBDDD#
@6XF
GTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCN
+
C@@FFFFFHHHHHFHIJFGGIJJGIJJGHIIIJIHJII?FBGHGEGIIGJIJJIJIGIHIJJJIIGJGIJHGHFEEFFFFFFEBEEDDDDDDBDDDDDDD#
@6XG
TCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGG
+
CCCFFFDFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFDDDDDDDDDDDEEDDDDDDDDDDDDDDDDBDDDDDDDDDDDDDDDDD>BDDD
@6XH
GTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTN
+
CCCFFFFFHGHHGIJGHJJJJJIJJJJJJJIJJJIGIHGJJJJJJJJJJJJJIJIJIFHIIJJJJGIEEHHHFFFFFEDEEDEDCDBBDDDDD<@D>BD@#
@6XI
TCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTN
+
CCCFFFFFHHGHHIGGHHEHGJIIIJJIIJIGCHGIIII?BGGIJIIJIIIJIIHGEFFDADDDDDDDDEEDDDDDDDD@BBDBDDBDDDDDDCDCCDDD#
@6XJ
GTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCN
+
??8==2=BA==2ACC?<CEE?EE:<3<C:+<CB?9??EE???D;16:6BBBBBD9*9?B?/88BC=CEIA;7@DCA7====C.?=7?.;?;);AAAA>;>#
@6XK
GGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGC
+
<@@DDFFFHDDHHEHEBGAHFFBEEEBHFHGIGDCFEGDH??9??DGHHIHEG:GGGEEFCCACE><CHEEFB;@@?A(3>?CDBDD>5:A<A93?A21
@6XL
GCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCN
+
@@@BDDDFHHFDHEGHIEGGGEHIIGGGHEIIDHGIJJJBCHIIJJIIJIJIJJJJJFHGIIJEHF:?B?AAEEECEDDDCCCC@?B3@ACEDDCCDCDD#
@6XM
CTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTG
+
CCCFFFFDHGHHGJIIJJFDDDDDDDDDDDDDEEEEEDDDDCDDDBDDDDDBDDDEDDDDDDDDDDCEDDCCDD@BBCDDDDDDDDCCCDACACCAACD
@6XN
GCCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGN
+
@@@DD:@:AAFD8DH?@B@DFHG7;=@=7@@EEC;=<BC>B@5>A;;?B=ACDCC5>>CCCC@?BC;>09>>CCBB:ACA>AACC>BB8?@B088::C>C#
@6XO
AAGACAGAAAAATAATTCTGTGGGATCATGATCTGAATCCTGAAAGAGAAATAGAGGTTCCTGATCAGTATGGCACAATCAGAGCTGTAGCAGAAG
+
@@BDFFFFHHHHGJJJJGGJFHIJJJJJIJJJJJIJIJJIIJJJIJJJGIJIJJIJIGIJIJJIIJJJHEHIGFHHHHHHFFFFFFEEEEEEDDDD
@6XP
GCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATN
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJFHJJJJHHHHHHFFFFFFEEECCDBCDDDDDDDDDDDDDDDDDDD#
@6XQ
CTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTN
+
??@?=DBDA?C?DDBGGGGGHGD9B@DACFG9F@@F;BHHEC1;B??ACC9@@CCCCCCCCCCC@>ACCA@A>CDDDC9CCC?C08?C@C?CC:?B88<8#
@6XR
CTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTN
+
@BCFFFFFGHHHHJJGIJJJHIHGHGHGHJIJEGGGIJJIIEEGDGGHCG;FFHHIJIJJIIJCAHGGGICHIGFHHHFFFFFFDC>@ACBB5?=BACC:#
@6XS
TCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGN
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJIJGJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFEEEEEDECCDEEEEC#
@6XT
CACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAG
+
CCCFFFFFHHHDHGIIIJGHHEHGGHGIFIIJJJIJJJJGIJIFIIGEIGHHJJJIGGGGCHIIIJJIIJIEHIGFEEHEHFFFFEECEEDEDEDCD:
@6XU
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFFFHHHHHJJJHJJJJIJJJJJJDDDDDDDDDDACDDDDEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDBDDDDDDDDDDDCDDB
@6XV
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
CCCFFFFDHHHHHJIIIGIGJJIJJJJJJIIHIIJIIIFIJGGGGIGGHHIHJBGHGHHII;@DEAEEHFFF??CEECCCCDDDDDDDDDDDDD05@DDD#
@6XW
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGCGCAGTGGN
+
CC@FFFFFHHHHFIGIEGHJIGHJGHHIIIJIGIHDHJJJGIHIFFFFHGIIJJJHIGHGIEGGGIHGHFFFFFFDEDECEDDBDDDDACDD(5<BD?CD#
@6XX
CAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTN
+
@BCFDDFFHDHHGGIIJJJIGIJJJJJIJJIIIJIIJGEIGGIIEIJGIGHHIIJGGIJIIEGIIJHHHGGFEFFFFDA><BDCDBD3;B3?B9?CCCCA#
@6XY
CCCGTATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
;@@DDDBAHDHHHI:CG@A?BAECEBFHIIGGDFBGHGDGI:@GGG<4=5;@E?;CCC>@CC@A;A?CCC;=B@BCA@CCCBCCCCD@C44>:>@>>BAC#
@6XZ
CAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTN
+
CCCFFFFFFHHHHJJJIJJJJIIJIJJJJJIJIJIGIHIJIIJJIIJIGIIJJJJJJJIJJIIJJGIJJJIE@FHHHHIIIIJJIGCEEEHHFFFDEFFD#
@6Y0
GCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGAGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTN
+
<??D1?DD:CADCE@@2A3A:CDE;EB??B?CEA;8:0??@DDD@DDC4BB>;AA@=@6AC@>A>C(,56@5>9?9'55555(:3>A3:><>>>AAA500#
@6Y1
ACCGCCTCTGCTGCTCTCACATGGGGACTGGGCCCAGATCCTGCTTGGTCACACCCAGCCCAGAAGACGGGTCCTCCAGTTCCAGTGACTCTTTCGGTGGN
+
@CCFFFFFHHHHHJJJJJJJJJJJIIIJJJJJJJJJJJJIIGIJJJJIGIJJIJJJJEGHHHFFFFFEDDDBDDDDDCDDDDDEDDDCDCCDDDDDDDDD#
@6Y2
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCN
+
CCCFFFFFHHHHHJJJJJIHJIJJJJJJJJJJJJJJJJJJJJJIJJFHICHIGIIEEHHHHGFFFFDAEEDEDDDDDCDDDDEDDDDDBDDDDEDDDCDD#
@6Y3
ATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCN
+
CCCFFFFFHHHHHJJJJJJJJHHJJJJJIJJJJJJJJJJJJJJGIHIJGIJJJJHIJJJJJJJJJIJJJJHHHHHHFFFDDDDDDBCDEDDDDDDDDDED#
@6Y4
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@C@DDAFDDHFFDEFGHJIIEHGIJJJJEGHIIJJHIJGIGHJIGHGGHGIIJJJHHGGIIJIJIIJJJJIII=AB?DDECCCEEEDDEDDDCCCCDBDC#
@6Y5
GTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCN
+
CBCFFFFFHHHHHIIJJJJJJJJJJJJJJJIIJJJJJJJJJJIIJJIJJJJJJJJJJJJJHIJJJJJHHAEHHHFFFFFFFEEEDD@DDDDDDDDDDDDD#
@6Y6
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
@@@DDA)AFHHDFHIAEEEDAB;;<EHGGGDIGIGEBAGEFHEEGGHIH<=@F9@FDGGIHAEE;@?B@BDDDCCCCCC>>;ACCAC:35:@?@CBB?+9#
@6Y7
CAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTC
+
@@?7DDDDFDF8DFIIFIIIICFFIIIFIEEFDFGFIBFIFIIIFEFDFFIEFIFFFIFABDDDDBBCCCBBBBBBBDBADABBBBBAAABBBBBBBBB
@6Y8
TGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGN
+
CCCFFFFFHHGHGJJJJFFHIIIJJJJJGHIJIJIJJGIJJJJJJIJHGIJIGIIJJIJJJGIIJJIJJHHHFFFFDCEDBCECDDDDBDDCDDCCCDED#
@6Y9
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
@C@FFFFDHHHHHJIJJJJJJJFHHIJHIJIGHIJJIJJJJJIIJIIIJJJIJJJIGJJJHHHHFFFFFFEEDDDDDD5>CCCCCCEDDCDDCCCDDDDD#
@6YA
TGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATC
+
@<@ADDFFHHHHBHGID>GEGCHGIIIACBFGGIBC?BFGGEGGHI@FHGGICBBFHICHGIEEEHE=CHE@>A>?=3;CCDCCD;@CC5>C>BB5@AC
@6YB
GTTGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJIJJJJJHJJIIGHHHHFFFFFDD=@DD@CDDEDDCDDDDDD#
@6YC
CAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGT
+
CC@FFFFFHHHHHJIIIIHIJIJJIIJIIJJJFHIIIJJJJJIJJIIIJJIJJJJIGIIHHFFFFDDDDDDDDDDDDCDCCDDCDDCCDDDDCCCDDDD
@6YD
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
@@CFDDFDFHGHHBHIJJIFHHIJJIIGIJJJJJIGIFGIIGGIIIIIIHIJIIJIIJJJIIHIIIJJJJJIJGFHFFH@DDDEDDCCCDDDDDDEDD
@6YE
GGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATC
+
CCCFFFFFHDHFHJGGIGHHIIJ?FHIJIJJJIJJJIIGJJJJIJJJJJJGGIJEEHFHHFDFFFEDDECDEDDDDDDDDDDDDDDDDDDDDDDDDCD
@6YF
AGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CCCFFFFFHHHHHJJJFHIJHIIJJJJHIIJJJJJJJJJIJJJJJJJJJJJJJHHHHHFFFFFFEEEEEEDDDDDDDDDDFDDDDDDDDDDDDDDDDDD
@6YG
CGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTN
+
@@CFFFFFGHHDHGIGIHIIIJIJJIJFHIJJJJJJIJJJJIJI8@FHHIIIJJJJIIHGHFFFEDEEEDDDDD@CDDDDDDDDDBDCDCDDDDDEDCDA#
@6YH
CTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGG
+
CCCFFFFFHHHHHJJJJJJHIJJJJIJJJJJHIIJJIJJJJJJJJJJJJFIJJJJJJIJJJJIJJHHFFFDCDDDDDDDDDDDDDDCDDDDDDDD
@6YI
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCC
+
@@@DDDFFHHH?FGIIIGIIIIIIGIBHFHGGIGCHFGCHHEGGIIIIIHIIFHIEGIEH=?HFDDEFDDBDDDEEDEDDDDDDDDDC@CD<CC>@DDA
@6YJ
CTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTN
+
@BCFFFFFHHHGHJHIIIJEFHIJJIIJJHIJCHIFHIHGIJJJJJJJJJJJJIJJEHICEEHGFFHDCCDFFEEEECEDCDDD?CDDDDDDDDDDDDCD#
@6YK
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
CCCFFFFFGHHHGJJIJIIIGHIHHHIJGHIFGHIJJJJJGHGHFHIICGIIGIGGGHG;AEHHEEFFFFFDCDDDDCDDD8@BCDDDBCDD>CDCDDDD#
@6YL
CGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTT
+
@@@D?DD>FB?2<2<A:AIC?CCC?<ACHHED@<<?9EECFD@????BB9?BBB?FGFB<<F;F;4=;.@==@=6;.?E=;;;BBDB;AA>BB;;;?=
@6YM
CACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGC
+
@@@AADB+2=?D4AEDFFFE@FHIE??+<ECBFE<0::@('''-:=@@>@A@C?BB8@?A/;;;@8:>:@>@?AA?::>A>@AAA(:4(:>:@3:39(2
@6YN
CTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTC
+
@CCFFFFFHGHGHJJJJFHIGGHJJIJJJDHGHIJJJIIJHIJIHIJIIIIHFDFFBECEDDDDDDCDCDD@CCCDDDEEACDBDDBCDDDDDDEEDDD
@6YO
CAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATN
+
?@<:=DBADFF8>FEFB<>I<+<3AC<4?EAFGECB;FCG>??FBG6DGGIF>?D=@CBFGD3).==77;AE65=B?(;;;5-;?8?9:;@(<B>>B3@:#
@6YP
GTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTN
+
@@@DFDFFFFHFGIJJICEFHGHGIIBHDGEEGH<FGGEHIIEGIGGEHHFEEFDFFDBDDBBDDC>C@9B9BA>?(:<:>@CCCAC:@ADDCDACDDDD#
@6YQ
TTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACN
+
=;@DBD;=:=<?D<FC?AA,3<CH?A::A+8AF;9:CFG>C9D1?0B9B?<99?D??DFF88.BCF@F:3=..)6@;7=E>;7.)=7.;BBD3.6@BA;5#
@6YR
GTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCN
+
@@@FFDD?FHFDDHIHHEC<?=B?B6=??BB0:?CDCCBCCBBB79BB8B5<@2?CCCCCDDC>AC@CCBBBBBBCCCCCBCCCCCCBBBBC4>@CCCBB#
@6YS
CTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATN
+
CCCFFFFFHGHHHJJJJJJJJJJHIIJJJIIJJJJIJJJJJJJHIIJJJJJJJJJGIJJJJJJJJIIJJJJIJHHHHHHFFFFFFFEEEEDEDDEDDDDD#
@6YT
CTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTN
+
@@@D?BD;AACFFE=?E)C8?FFFFGCB9:?DGGGAGBBB@DD2D9=8====FCAFEADF==CCAEAA@B?B>@A>6;;=@B899>?5>AB@>:::A+4:#
@6YU
TGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCN
+
@@@DDBBD==<?DHEHID@EGCFEFBB??AGIIIGEACIEB:9?DAGIIGEFHDGCHGHIG>GEGE@AECE9?<ACBBBB=899:?8<?ABCCCCCCCCC#
@6YV
CCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTTTATTTCTTGGTTCTTTTGCAC
+
@@@DBADDFBDAFF>FF@I4A<B@BH>BE@?CBCHFE<CB?D6C*:BDC9D>GBDE:9BFFA??/=8BCACFF@FEAB<=AC>(;@A@5=A@>:53(,(
@6YW
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJIJIJJHIJJIJJJJJJJJJJJJJJIJJJJJJJJIJJJIJJJJIHHHHHHFFFEEEDECDDCDCCDDEDCDDDDDDDDDDD
@6YX
TCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJIIIJJJJJJJJJJJJJJJJJJJGJJJIIJJJJJIIJJJJJJFGIIJJIHHFDBEEEDDD=@DDDDDEACCDD#
@6YY
TGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCTN
+
@CCFFFFFHHHHHJJJJJJJJIIJJJJJJJJHHIJJJJJJIIJJJJJJIJHHHFFFFFFEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6YZ
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGN
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJHJJJJJJJJJIJJJJDIJJJJJIJGIJJJJHHHHFFFDDDDDDDDDDDDDDDD@CBDBCDDDDEEEDDDDDDD#
@6Z0
GTTCTTGTCATAGTAGTACCGCAAGGCCCGGCTGAGCTTGTCGTAATTCATGTTGGTCTTGTTCTTGCGTAGCCCCCAC
+
@@@FFFFDHHHHH?EGIGHIJJJJJJIIJGIIIJHGHGFIJIIGIJHGHGHEGHJFACHHFFFDFFFFDCB>@CDDBBD
@6Z1
CGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTN
+
CCCFFFFFHHHHHJJHIIJJJJJJJJJJJIIJIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJHIIJJJJIIHHHHHFFFFFFEEEFFEEDDDDDDDDD#
@6Z2
CTCGTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCN
+
@@<BBADDBBFDFGGHG<@FDCGCHEEG3?88?FHGIGGGG@B==DG7@6@EEDEA?EHDDDEDC?AA>>@>@@CCC>@CCCA(:>B?:A:>@C8AC@CC#
@6Z3
CCCATCCCTGTGCATCCCTCTGGGGCTATCTAGGGCTTGCTCCTGCCCACCATGCACTTCTCTTGCCCGTTTTCCTGAAGAAGAAACCTTTCCAAGGCA
+
@C@FDBDDHHHHHIIBHGIGEEEGIIIIIIGIIEDHIGHH@GHBHIIGHIICHFCFHIEHIIIIEFHHFDFFDECCCECDDADDDDDDCDDDDEDDDDD
@6Z4
GCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCN
+
8?7?+AB:2+ADDE;C+<AF<<?E:CFEC992CD)?CDDDEEAEBBE*990B9*/?BDBEE<8@5/(@777=?;?A@??;>;@A;>(;5(-;>A559(,5#
@6Z5
TCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATC
+
@C@FFFFFHHHDHJJIJJHJJIGIIIJIIIJIIJIJGHIJJFHIJGIIJJJJJJJJJJGIIIIHGGIGJJJJJIIGHFHHHFFFFEEEEECDDDCDDC
@6Z6
CCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTTN
+
:::B=B:BF<FFDIIEFB@FHF4<I3<<<<,2+22AF<<?CFCGCGFD???C??D<B?BBGE:*B?*==BB88B@)@A).88=D@EE@;A=C:CDB;7A)#
@6Z7
CAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTN
+
?<1BDDFFHFFH>CFFEHACFHHIGHHF<BHGAC<@EFHGGHGEH@GGBDEIGHAEHBFGGIGB<88BG:@GGGHAFAEHADHGC?CCCCDF@DDFEE@C#
@6Z8
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGN
+
CCCFFFFFHHHHHIJJJJJHHIHGIJJJJJJIJDHIIJIJIIIJIIIJJHIJJJJCHIJIJJJHHHGFHFFFFFDEEEE>ACDCCDD<ABBCDCDDDD<A#
@6Z9
GGGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATCTTTTAGCTTTGAAATTN
+
@@CDFFFFHFHHHGGIJIIJIJIIIJGJJJIHIIJJJJJIJIJJJIJJJJJIJFIJJJJJIIIJJJJGIFGIJGIIJIEHIIJJHHHGHHFFFFFFEEEE#
@6ZA
GTGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCTTGCCAGCAAAGCAGTAGTTGGGGTTGTAGTCGGTCATGATGGTCGAGGTGCN
+
@??DDFD?DFHHHGIIGAD?FFGCDHDHEBGC?FGEAA=BC@5(5';7@EEHH@@DEFBC@>;.-(>>@>?B;;85@C>4<@BBBC@>@C:(:<<9<&8:#
@6ZB
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJBHFDEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6ZC
GTCAGGCTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTN
+
C@CFFFFFHHHHFHHGIJIJJHIIJIIJJJJJJJJJJJIJJJJIJFHIJJJJJJJJIJJIHHHFFDFFDACABDDDDDDBDDDDDDDDDDDDDEEEDDDD#
@6ZD
GCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTN
+
CC@FFFDAFBBHHGBGHIIIGDHGHFFEHCAHIIIIIGG?@D>BBEEHIFBHHCADGF8?F==CFGFDGG@;CEGIIB=;CEEHDDD)?BED>>CCECDC#
@6ZE
GGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGT
+
@@8DDDADHHHGGEFGIJHGGHGHEIJIJJJJJGGHHIJIIIJJEC?DHIIJFGIGJGJJJHHGGHHFHFFFEFFEEEEEEEEDDCDDDDDDCDDDDDD
@6ZF
AGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
@CCFDDDFHDFHHIHHIJEGFHCHHHFEEHDCDHHEIG>FBGFDHEGCBD@FGGIGGGBEHIG;>AEEH@BCCBA@CCCCCBDCDB<ABB:ACB9?@BDD#
@6ZG
CTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCACTGTAGCTAGACCAAAATCACCTATTTTTACN
+
@@@FFFFFHHFFHGHIGIIGIIGIIGIJIGHIIJJJJJJIIDIIJJIJJIJGIIGIGIIIIIGHGGHA>?C@CHDBDFCDCECDDDDCADDCCCDEDCDD#
@6ZH
GTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGN
+
@@@DDDDDHHHF:EEHIIEHH?GHDHGIGCCH@FGHIIHDFHIIIIIIG@FHGIGGIIHIIIC@FGIIIGICHA;CFF@EHHIIHHFFHEEEEEEEE@DC#
@6ZI
CGTCCTTGGAAATTTTAGAGCGGTCACCTAGGGAAGGCTTGGATAGAGTGGCCACAGGACCTCCTTCCCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTN
+
?@=ADDDDFDAFHIEB@@+C9?@FHGG9EDGE3BF<DFFH:;D<B>G>8.11@=FEHIHH=C@DDB@D@CB>>@@@@>>@CA>3:<ABBBB?ACA?@CCC#
@6ZJ
CTCCGGTTCTCTCCTGGTCCGGAAATTCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFHHHHHJJIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFBCBBCDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@6ZK
GATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTTTACN
+
<@@DDDDDD<FFHHGHIGHEIGC<CFHCFGHBBFHE@FAGHHI9?FGCGEEHEGG?GBC:*BBF@DFGGIGG<CHG=@C=FCAHGGEGC>?CEEFEEEED#
@6ZL
CTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCC
+
@@@FDDFDFFFHGJJGIJJIIJJIJIIHJJGIGGDGIGIIGIJGIGIGIHIIIIJJJIIIGIIHICEHEHGGEFDFFDC;>ACCCCCCCDB?BDBDDDD
@6ZM
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJHHHHHFFFFFFFDDD;BDD@DDDEDDCDDDDDD#
@6ZN
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
CCCFDDFFHHGHHIIGEGIIJIJIIJHHJJJJJIIJJJJJJHIJIGFFGIIJIJGIJJJJJGGHIJGGIGC=BEEFFF>ACECCEEEEDCAC@A?BBDDD#
@6ZO
GTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGN
+
@@@FDDBDHHFFHIIECFFIGIIIDHIIIIIIIIEEGIIIIGHGEHIGIGICDFB=FHGFG@FFHIGDCGEHGGHHHGHFFDFFFFCECCECCCCCCCCC#
@6ZP
TCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTN
+
??@DB?=BCDHHFBGEFGIC>FHC>HHGIIGGGICGIIIB6BF9D=3=@FE@@ACEEEC;B>@@@C@CCB5?;8=?=39>@:@:>:CCCACC:>::@:@:#
@6ZQ
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
@@@FDBDBFFHHFHIGHIGIGGI<CD?DFGEHEHIDHIIIIEGGGIIIIIIGHIGHGBFFCFE@ACCCECBCDCDEEFD>ACDDD>ACDCCDCAB?CCA
@6ZR
GTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGGGTAAGCACTGTAGCCCTGCTN
+
8?<B7BDDFAFFF9FE:AIEFH@<EHEFEH;FCB<FD:CFAA<?;6:D:(9/9.)8/)8CFIE=;FE@:5=EEF>B=@B&009A>A:?BB:@3>@A9+<>#
@6ZS
GGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCN
+
CC@FFFFFHFHHHGIHGGGIIJJJIJIJHIHIJJJJJIJIGIJJJJJJJJJIJJIIIJJIIJJJJJJDHGGHGHHFHHDFFFFDFEEEECEDFEEDDDDD#
@6ZT
CTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCN
+
@@@DDDFFDBDHGGGGGGIHGHEGHEIJHGCHEGHIJDDHIGFFEDGFIJJJJGHGGGFECEGHGF@DDGHIEFEAHB@BBBCEEC?CCAC@CCCDDDCD#
@6ZU
GAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTN
+
@@@FFDFFDHHBBHGF>DEHGGIDEEHIIGBBGGGI9BFEIIEHJJGIHFFDAEEECDDBBDBDDD;@BDDDDDDCACEDDDC@?CADDDDCDD@DDDDD#
@6ZV
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJIJJJJJFHJIJJJJJJJJJJJJJJIJJJJJJJJJJJJHHHFFFFFFEEEEEEDDDDDDDEFEDDDDDDDDDDDDDDDDDDDD
@6ZW
CCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJ@GIHJJJJJJJJJJJJJJJHHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDEEEEDDDDDD
@6ZX
CAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGN
+
@CCFFFFFHHHHHJJIJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJIJJIIIJJJJJHHHHHHFFFEEECEEEEDDDDDDD?CCEEDDDDDDDDDDDDDD#
@6ZY
GGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGAGTTCTGCTGAGAGT
+
@@@DDDB?FDF;FFEHGEGDAGI;;:3C?*CCFG>4BF;G4??<BF*?????BCB:8=F=@A=CGH47)..;B?8>>@;;?5(((-5>5;5:>(5(,5A
@6ZZ
CCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATAC
+
CCCFFFFFGHGHHIIIJJJIJHIJJJJIGIIGIEHIIGJIJJJJGGFHIHGGGIHEIGG7==CHGGGGHHHHHHHFF@CFDDCDDDDDDDDCCABACC
@700
CGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATN
+
@@@DDD>=DFFHDGDGGG@DA:<:CDHGGIBDCHE?G@9?DD??F=BCDFHDGEHAHBH<BBB@??>CACCCC9A2=02<CCCACACCC@4@AB@CC::@#
@701
CTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCN
+
CCCFFFFFHHHHGIJJJJJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFCECEEEEDDDEDEDDDDDCDDDDDDDDDDD#
@702
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@@FFFDFHHHHHJJJJGEHGIGIJJIGGIICFHJIJIGIJIIJJIJJJJIJJHIIIIIJGGEGHHFGHFFFFFFDE6>@?>ABD8?BDDCCD<BD2<A
@703
CGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJHIJJJJJJJIJJJJJJJJJIIJIJJJJJHHHGGHFFFDEEEEDDDDDDD=@B9CDDDCDBDDDDDDDDDDD#
@704
GGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTN
+
@??BDD6@C??F?G?DD::3*?GIBB?7FC=@FFFF7@7=.77=97?72;?'.=<(;=/;2=,9:?BBBBBB??<2<?>B0<BB9(4>A?B(8&4>3+>@#
@705
GTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCN
+
;??1A8?AADCA:<?@EEDFF4:<94+<+?EBB08?;B))0?DB*8.(=@)@3==CDADD<AA'99=(65AB;5((-,38(<A39<A><<(:((082&59#
@706
GTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCCAGTTCCACAGAGAAGCN
+
CCCFFFFFFGHHHFHGIIGGJIJJIIIHGHHIGIIJJJJJJJJJJJIIJJJIJJJIJJJJGGIGGIJJGGHIIGGGHHHHHGEEEFFFFDEDDECCDDCD#
@707
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@@@DFBDEHDHFD@DGD<GHIICHHIEH<?DDD@DH@:?BFFFCGG?@A?F=CF@;F7;CA@>ACCC@?;BC;>>CDCCCCC?@BBBBAACCC@A:AA
@708
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJFGIHIIJJJJJJJIJJJJJIJJJJJJJJJJHGFFFFFEDEEEEDDDDDDDDDDEFEDDDDDDDDDDDDDDDDD
@709
CACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTAGCTGGGGCCGTTGCTCTGTATTCTTACN
+
???:D;:=+<+ACC4C;)@C1<94*)1):C6*0?)?3?(7'-)@A)8@8AAD<==?7?(-;(55(:(8('->(4:(4<?>-00;5>-:3((>:(4:4:3:#
@70A
CCCAAATTTAAAAAATACAAAATGAGGGCCTGAAAGAACAAAAATGAACCAATGTTAAATGATACCAACCATTTCACACAGTCTGTATGGCCCAGGTAGTN
+
CC@FFFFFHHHGHJJJJIJIIJJEIIJJJJJJJJJJJIIJJJJJJIJJJJJJJIIIJJJGIIIJIHHHHFFFFFEEDEEDDDDDDDDEEDDDDDDBCCC@#
@70B
GTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGN
+
CCCFFDFDHHFHHIJJIIJJIJJIIJJIJIIJJJGIJJIIJJJJJJJIJJEHIHIJJJIJJIIJJJHHGHHFFFFFFEECDCDDDDDD<=B2?B5@CDDD#
@70C
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
=:?DDDDDDBA::EE?CEF<3AADEEEED)CDD<6@@D*//)8)8BD6@ACCCCDDCA>DD>A36>;;AAAA=?B>:>>A>:>AAA>>>3>(++++:>>:#
@70D
TCAGTTTTGACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJIJJJJIJJJJJJJJJJHHHHHHFFFFFFEDEDEDD#
@70E
GCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGN
+
CCCFFFFFHHHHHJJJJJJIJJHIGIIJJJIIJJGIIJJJJIIJHIIJIJJIJJJEHIJFIIJJJHIIIHIIIIJGGIIGEHGHIIHEHHHEFFFCEFFE#
@70F
GGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGN
+
@@CDBD1ACFDFFIGGGCHCHHGEHHIFHIBBFFG@HGGEF@CDDGHIIIIIIGHIIHGEEDEDCC5=ACCDDCA/;<?@@>?CDDD1?<<<AD>?CDDB#
@70G
CCTGGGGCAGGGCTCCCATGGGCAGCGCCTGCATCAGCAGCGGGGTGGCCATGCGCATCTTGCTCACAGGCTTGGGAGGCTTGGGAAGCTTCATGCGC
+
@C@FDDDAHDHDHHGIIJHIJGGIJJIEGIEEHIIIGIGJGHGGD9??ADC?CDDDDDB@CCCDDDDCCDBDDDDDB<9?BCBBD2>?BACCCDCC9<
@70H
TTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCN
+
CC@FFFFFHHHGDFGEIIJJJHHHJJJIIIIJJCHGGIJIIJIJGIGIJIJEHIEGHFGGGIGIHJGHGHICGHGHHIJCGIGGIIEIHHFHHHDFFFFD#
@70I
TGGGCCTCACAGGCACTTTCTCTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATN
+
@@?=DDDFHGHAHGGIIIIIIIHGIIJIJIJIIGJJJDGIIJJJJIIIEDHIG?HBHGGIIDEEHFFFFDEEEEEEEBBBDDDDDDDA@BDD>CCDDCDE#
@70J
CTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGN
+
CCCFDFFFHGHHHJJIIJJIJJIJJJJHIJJJJJJJJJJJHJJJJJJJIJIJJIIIJJJJHIIIJJIJHFHHFFFFEEEEEEDDDDCDDBBDDCCDDDAC#
@70K
TGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGCTGAAATTN
+
CCCFFFFFHHHHGJJJJIJJJJJJJJJJJIIJIJJJIIJJJJJJJJIJJJJJJJJJJJGIJJJJIJJJJJIJIHJHJIJHHHHHFFFFFFFDEEEEEDDD#
@70L
CCTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTG
+
@@@DFFFFHHHHHIJFFGHIIIIGGJBGGGIIJIGIIIJJJJIJJIHJHJIJGGHIIJIGIIIGIDHGGFHHFFFCCDAEEDDDDDDD@CCCCCDDED
@70M
CACTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
CCCFFFFFHHHHGIIIIJJJIHIFGFHGIJIJJIDFIIGIIJJGHIGIJIJJJICGHJJHGGGHIJHIGIEGHFFFDCC>CCDDDDBDDCDDCD<CDD
@70N
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
C@@BDFFFHFHFHJGIJBHHHHIIGCHFFEIIDBGHIIIHECGGICFHGEHBFFAHFFBBCC=AEFFEEFDDC;;;A6;?,;CCDEACCCDDDDDDDDD
@70O
TAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCN
+
@@@DFDDFHHHGGIEDFHIJICFHGHIJIFHIHJGIJGGIIJJIIIIIJJJEHECAHEFFEFEDEEEEDDDDDCDDECCCCCD>CCBCDDDDDACCC@C?#
@70P
CTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTTGTTCN
+
B@CFFFFFHHHHHJJIJJIJJGIIJJIIIGHHGGHIJJJIIIJJJJFHIIJJJIJJJJJJJJJHHA?EHCEFFEDEEEEEEEDDDDDCDDDDDDBD@DDC#
@70Q
CGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGAGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGCN
+
?@@DDAD;CB?CFFHAE?I:A??F:?F?F9?1::?E:??1110:D:?@@?(=F2C;-(-=D7C7775,5=';6(----=2;;B:A:5(+000059ACC8(#
@70R
CCCTTTTTGTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJIJJJJJJJJJJJJJJJJJJJJIJIGHIFHHHEFHFFFFFDDDDDDDDBDB
@70S
CGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGN
+
CCCFFFFFHHHHHJJJJJJJJJJIFHHJJJJJJJJJJIFHJJJJJJJJJIJJJIJJHFFF?BCEDDDDDDDDDDDDDDBDDDDCCCCBD?BBDEECDCDD#
@70T
CTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTN
+
CCCFFFFFHHHHHGIIJJJGIIIIIJEIJGHIIJEHIJJGHIIIIJIIJJIJJIIJJCEFHHHFFDEDEEDDDDDDCDDDDDDDCDDDDDCCDDCDCDDC#
@70U
TTTAAAGCAAGAGAAAGAACAAGTTTCATTGAGATGTAGAGAGCTAGAAATCATTATTAACCACAACAGGGCAGAAAATGTACAGTCATGTGATACTCA
+
CCCFFFFFHHHHHJJJJJJJJJJJIJIIJIIGHIJJIJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJHHHHFFFFDFFEEFEEEDDDEEFDDDD
@70V
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@@?DFFFFHHHHHJFGGHIGFHEGEFFGBFFGIE?CFFHIEGGHJGJGHJJJJICGFEHHGEHECEGGFHGFDDDDDDDDDCDCDC@BCCDCCCD>ACD
@70W
TGCTGTCACAAATGGAGGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTCGAATTGAGGGCAGTCTGAGTAAGGATAAAGTTCTGAGTTN
+
CCCFFFFFGHFFHJIIJJFFGIGFIJJJJIJJGGIJJIJJIIGIJIIFGGIJGGFHEDCEEDDDDDDDDDDDDDCDAACC@CDDDCDDDCDDDEECCCDD#
@70X
CTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJIIJJJJIJJJJJIJJJJJJJIJJJJJIJJJIIJJIIIJJJJJJJJJJJJJJJJJJJJIJJHHHHHFFFFFFEEECE#
@70Y
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCCGGN
+
@@@FFFFFGHHFDEIJJJJJJJJJIJGGIIIGIGIIJIIIIBDGHIJJIHJJJHIJJIJJJJIJJIJIJJI@EH?CCF7@ACCCCEDDDDAC;@BBB5;@#
@70Z
ATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGC
+
CCCFFFFFHHHHGJIJJJJJJJJJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJFHIEGGIIIJJHHHHHHHFFFEFDDDEDDDDDD@DDDEDD
@710
CGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCAC
+
@@@FFDDDHHHGHHIJJJGFFDFFDFFHEGGHIIEHJIJGGD:BG:BGFFFEGGIGIHIGGDFBFHJIGECCHHEFGFDBCDCCECAACEEDC>CC@CC
@711
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJIJJHHHHHFFFFDEEEEEDDDEDEDDDDDDDDDDDDDDDD
@712
CCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTN
+
CCCFFFFFHHHHHJJJJJJJIHHJJJJJJJIIIJJGIGHJJJHHHHHFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDEEEEEDACDDBCDDD#
@713
CAACAGGACACCAAAAGACCATACATCACTTTGCGTGGTGTAGATATGATCAAAAAGGGATTCAATTGCCATCCATTTAACTGGAATCCGACCCTGGCTCN
+
@@<DBBD8FDFHFBEGAEEFHGGG3C??CEG@GGI0@<F=BDH<?FHAGGAEI4=@F7=@@DCE==?;;B@:B;;>B@C:>>@CCA>;:@?=?<??18+>#
@714
CGTAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
?@??D?DDAD?FFBGE4A:?CFFIEHBECE@?EBDGFFEGDGE>FGEFIEFFFFCCDFFIIIGGCE=;@?3)=D(;?@;@A?A??89@@BB@ABABBBB<#
@715
TTCCAGTTGTGCCCGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCT
+
@@@FFFDDDD;FFHGFFDHGGHJIGGJIGEGGHGIJGHGGGJIJJHIJJIJJHCHIIEIGGGGHFDGBHHEHHGFDDFFFDDEECACCCDDDCDDDBAC
@716
GCATGCTTTTTAATTCAGAAAGTTTCCCTAAAGTCTTGAAATGATTAAGAATACATTTTTGGTATATTAATCAAATGTGTCAGTTTCTTTATGTTATAACN
+
CCCFFFFFHHHHHJJGHIJIIJJJJGJIIGGIGHIJJIJJIJJIIJJJIJJJJJJJJJJJJICGIIIJJIIIIJJIJHGHHIJEHHGHHHDDEDEDDEEE#
@717
CCGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGAT
+
=B@FF=ADFHHDHHJIGIHJIJJJJFJJJGHGIIFEHGGIIGJGIJ@FGIDGGIIHHHHHHF?BCCEEDECEDCCBCDDDDDCCDDCDCDDCDDDDBDD
@718
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
:?@DBDDA?FD><C9F?@3@G<<<99ECFBGAGF@F8??BB3;9BF?8.BF87@@7@;@;2===A)7@;<AA26;@3>55>;>A((5<@A((::?>>:
@719
ATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTN
+
@@@DDDDFGHHHGIIIGIJJIIIGEHIJIIHGIGIIIGIEHFHGIGFGHEGHIIJIGGIJIJIGGCHIHIIHEEDDCECEDEDCDDD@B5909?BDDB<@#
@71A
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJIJHHHHHFFF9?B@DDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@71B
AGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGG
+
BC@FFFFFHHHHGIJJJJJJIJIJJJJJIIJJJJIJJJJJIJGHIIJIJJJJJJJJJJJJJJJJHIJJHHFFFFFEEEEDEDDDDDDDCCDDDDDD
@71C
CTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAA
+
@@@DDADDHBDDDAEFB4IG@FECDAFH9FH>:1?FH?B*?8BDGBABBFDFHCDF*/?F<=FCH7ACHIC>;=AADB>;??;66;@C??5=>ACC?CB
@71D
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
@@@DDDDDFDHAFEB>EEAAE7EAFECHIII>EEBBB:?BF;BAD@BFHGGC?BB?BBFGI@FCA@FHIIII@@EAHHCHEE?B>3;CCC@CDDCCCACC#
@71E
GGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGN
+
@@CDDFFFBHHFFBACFGHIJIGIIJJIGHGJJIGIJIDHFFFFHGHFFDFEFCCC?BBCDCCDDDDCDDD<9@BCDCDDCDCCDDDDDDDDCCDDDCCD#
@71F
AGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCN
+
@CCDDFFFGCFHFIIGGGIJIJJJCHGIGIIIHGJGIJJGHGEHJIIIIJIJGIDGFHIJGIIJIJJJFIIJIJGHHGHFFFFF;>B@CDCDDDEEDDCD#
@71G
CGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTN
+
C@@DFFFFHHHHHJJJJHJIJJJJJJJJIJJJJJJIIIJJJIJJJIJJJJJIJJJIJJHHHGHFFFFFFEEEDDEEDDBBBDCDDDDCCDD<BBDDDDDD#
@71H
GTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCN
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDDDDD#
@71I
CCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACAC
+
CCCFFFFFHHHHHIJJJJJJJJJJJJIJHIJJIJJJJJJJJJJJJJJJJJJJJJHHHHFFFFFFFEEEEEFDDDDDDDDDDDDDDDDDDDDDDDDDDD
@71J
GTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTN
+
C@@FFFFFHHGHGIIJJIJJJJJIJJGJIJJJIIJIJJBHHFFFFFEEEEEECDDDDDDDDBDBDDDCDDD>BD2<ABCCDDDDDDDDDDDDDDDDD>CD#
@71K
TTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTCTN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJIJIJJJJJJJJJJJIJJIJJJJJJJJJJJJJJJJJIJIIIJIJIIJHHHGHFFDFFFEAE#
@71L
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
8=@DDAADFBCFF>GG9EII>HH@CFGE@F>EGG>FG<??BGHIAEH>D?D8DFCF=GC;C=7=FGEH=CA8/;4;>@BCAA?ABCC>>@C?5:>?ACB@#
@71M
GTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGAGGTACCTCCTTCATATTGGN
+
@?:ADDADFFFFDHIIIFEHEBGHG@BFG@HEBFGGDGGIHIIIHE@F@DHIIEGEHCEBBFFECEECB?ABCC@CCCA<>?B5@CC@:ACCCCDACDCC#
@71N
TCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGN
+
@CCFFFFFFH@BHGBHIIG=GHEEG>FGFGEDGHFDGHIDIIIIIIGAFH;BGGGIAH;EFDFE>A@E@BDBBB?A??A?A:>CCCC:>B<>@0<<@A@C#
@71O
CGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTN
+
CCCFFFFFHHHHFIJJJJJJJJJJIJJJJJJHHIIIJJIIJJJJJIJJJIIJIIGJI;FHHIJJGHHFFFDEEEEDDDDDDDBCDDDDCDDDDDDDDDD?#
@71P
GCAGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGN
+
=?144?DDFD?;F<EEFFBD:<C?C<EDFG<?G9D@:?;B0?F?9DBD<FH?FE@B>=C>CC>=4@@=?E=B?=?(.,'9@<'8A35:A;5(4>4(342?#
@71Q
GGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTG
+
CCCFFFFEHHHHHGHGGGJJJIJIJHHIJGIJJJJJJJJJJJJJJJGHJJJIJJJJJJEHHFFFFFDEEE@CCDDCACD@CDDDDDDCDDB?CCDDDCD
@71R
CGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJHHHHFFFFEDEEDEDDDDDDDDDDDDDDCDDDD#
@71S
TGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGN
+
@BCFDDFFHHHHHJJJJJJJJJJIJJJJJJJJJJJIJJGJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJGHHHHHHFFFFFFEEEEEEDDEDDDED#
@71T
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@<@DBDDDFDDHA@FH@B:CCGEGG@DCHGBEGGFBEB?DGCE@DE?B9?B@AF@FBFHHBGB5=:B3>CCDCA;AB?B?;1<<?3:ABBC3?CCAAC>C#
@71U
CCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTN
+
C@@FFFFFFHFGGGIFGGIIIDHGGHFDHHHIGHIGHHEEHGBFHHIGBBGHGCEHHIIIGHHFFFCDCACEC@B3=?3>>CDCCDDDDDDDDACACCCC#
@71V
ATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
@@BDDDFFHHHHHJJIJJIJJIJJJJAFHFHIJHGIJJIIJJIJJIJDHGIJJIJJJJFDACEEDCDDCDCEDCCDDDDDDDDBDBDDDCDDDBDCCD
@71W
GGAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGN
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIIJJJJIJIIIJJJJJJIIJJIHHHHHFFFFFFEDEEEEEEDDDEDDDEEEEFDDD#
@71X
GTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAA
+
@C@DFFDDHHHGHGIJJGIFHGHGHGIJGIJJJJIIIIIGIICEIFHHFFCDCCCACCDDDDDDDCB?CCDDECC>CDDD99>9@DBDCDCDCDCCDDD
@71Y
CCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGN
+
+=8BDDDD8DABF9A<EBHGGH@AFFHIGHGEBGEGI6.7BEBCDE@CG.7C97C)=;=?A?3;;?ABCA.;(;A>C>C<C>3@CDCCB@C<++:@@:AC#
@71Z
GAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
8:?D;:B;DF2@@CEF:E49CB?ECE9?*:?:1:)0:?B<D?<AFFFEF=B=)).==@F=C@=2?7555(;9=>@?B>>@35><@BBBB5<@BAB4?:
@720
TGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTN
+
=?1B1=2A:CD?DEA<E<E<4?+::FFIACBDEA<ECBE??D9::?DBEID>?B??<D8*9*88<8=84ACE@7)=@C@CCDD>=CDD:@A?;..6@AA=#
@721
CAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTN
+
@?@DFFFFHGFHDFGGGHIIGHGGBDHHIIHGIGIGGHHGIGIIIGIFHIIGGIHCFHHIIIGGEGE@;?A=EEEF@@;@@CA>C@DCDDC;;;@CDC<@#
@722
TGGAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCN
+
@@@DFFFFHGHHGJJJJJHHGIJJJJIJIJJJJJJIJJJJJJJIJIJJIJJJIJJIJIGIJJJJJIIICHGIGIJJJJJJHGHFFGFFFFFFDEECDDDD#
@723
GCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTN
+
=81:?+A+A=ADBED@DEDEFEEIIDCDBB@DDDDD99BBBDBD?D??D<BB=@C;ACCEEAEC@;=?CDA@A?@D>@8,;;??>AAAAA>A?AAAAAAA#
@724
GTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTN
+
?@@DAB6D@@DA)AE?<FDF<CB=D0?D9)0*9DAE8B=CD@CAD@CDCD>DE>>)));:).;@>(>>A>C;@@A<@(3>>?8,5>?CCCA(:(:@+2:>#
@725
TGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCN
+
CCCFFFFFHHHHHJJJJIJJIIJIJJGIIJJIEHJJIJIIJJJIIJIIIIIJJJIGIJFJJIJJJHHHH;@D7@CEDEEEDCDCCCDDCBDDDDDDDDDC#
@726
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@@@FBD;DCHFHHHG@FHIIECHGHIIGIH@GHGGGHFFCGGGBIB?GGI>FDGHI=FHGIID5:=<>>A@CA>;ABDBDBDBD@CCCBDDDCDDDDAAC#
@727
GTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCTCCTCTTGGGTTGGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGN
+
@@<DFDFFHGFHHHJIIGBGIGGIGGGIIGGGDHIHGGIIGIIECHHIGGGHICIHFF=ADFABCCDFEEDECED??BCDC@CCC<@BDDCDDDC?@B>B#
@728
GTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTN
+
CCCFFFFFHHHHHJJJJJJJHIJJIJJJJJJJJJIJJJJJJJJJIJJJJJJFHHJIIJJJJIHHHHFFFFFFEDEEEEDDDBDDDDDDDDDCCDDEDDD?#
@729
TGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGN
+
B@@DDFFFHHHHHJIIJJJJJJJJJJJJIIJJJJJJJJJJJJJIJHIJJJJJJDHHHHFFFFFFDEEEDDDDDBBDDDDDDDDEEDEDDDDDDDDDDDDB#
@72A
CTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCN
+
CCCFFFFFHDHHHGHHIIJJJJIIIJJIJJJ?FHHJJJJJJJDHIJJJJJJJJJJJHHFFCEEEEEDDDDDDDDDDCDDEEDEDDDDDDDACDEEEDDDD#
@72B
GGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCN
+
?<8B?AD;?FCFA@D?ABBEFD?<GE@EE<BGFCEF>D@CFFEBBFE@<<BDF?DFFC.=AB37C@@E@:=/9??6>.6;@>@>A>AB:9??3>:?35;(#
@72C
CTAAAATCTCATGATTATAATCCAAGATTCCTTTTAAAATTTTCTTTAAAATGCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTN
+
@@@D?DD:DCC:AA?FFIF<:A<:ABG3F><<C?CDBB??CC?CDFDF<9*?DGDG4??FD<?9B8?88B;=F>FCFIGIICFACEE.7=??;;?;?>>A#
@72D
GGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGN
+
@@BDDDFFHGHHHIIIJJJIFHIJIGGGEGHIJJIGJIIJJJJJJGIIIHHH@GIJIIJEEHFHIIJJJJGGHHHFDFD=>BB8@CDEDDCDDBBDDDDD#
@72E
CCCCAGTGTGGAATCACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCACAGATCACTGGGATGCCCTACGGTTTCACAGCTCTGTTCTTGATTTTCTN
+
@@@DDDABDFBFHG><3:C:C?FAG@FAH<@>*8E?8C;DGH@FFG9>DGGDF;=)8CAACEE<;C2@?AHCBDEC>CDC@>@>;5>5,:>@C>5;@C@>#
@72F
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
@CCFFFFFHHHHHBFHIHIJJJJJGHIJIJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDFDDDDDDDDDDDDDDDDDDDDDC#
@72G
CCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTT
+
@@@DBDB:A??DD@C?AAEGDH4FGI@GII?F@?F@F?DGGIIB@?BF8?9BCCCCBB@@CF@F@8.=C5?=?=??EDE;BDB@;?AC;;;55555:A>
@72H
CCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCN
+
CCCFFFFFHHHHHJJJJIJJJIJJIJIJIJJJJIIIJJJJJIJIJIJJJJJHHFFFFFFEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD<BBDDD#
@72I
TCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCN
+
C@@FFFFFHHHHHJJJJJHIJJJJIJJJJJJJJJJJJIJJJIJJJJJIJJJJJIIJJJGIIJJIHHHFFFEEEEEEDDDDDDDDCDEEDDDDDDDEEEEC#
@72J
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@@@FDDDDHHDHFIJIJJJJIIJJJJIJIGHEIEHIFHIIJIIFIDEGIFIJHJGHIIHHIJG;AHFACEEECC;@?BD??BDDDCCDDDDDDCCDCCDC#
@72K
GGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCN
+
CCCFFFFFHHGHHJJJJDDDDDDDDDDACDDDDEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDBDDDDDDDDDDDACDDDD>CDADDDCDC#
@72L
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJGIIJJJJJJJJHIJJIJJJJJJJHIJIIJHGHHHHHFFFFFFFEDEEDDDDDDDDDEDDDDDDD
@72M
GGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTN
+
@@@FFFFFHHHFHIIIIJJEHGIJJICFGB@GDHGIHIJIBGHIIGIHCEGGHHGHICFIGIIIEEHFFFDFDECCAEDCCDFEEDDEEDDDBAADDDCD#
@72N
TTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGT
+
CCCFFFFFHHHHHJJJJJJJIJJIJJJJJHIIIIIJJJJJIJIJIJIJJJIIJJJJJJJIIIJJJJJJIJJJJJJHHGHFFFFFEDEDDDDDDEDDDC
@72O
CACATGAGTTGAATAAACCAGAGAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFEFFFFFEEFEEFFDDDDEDEDDDDD
@72P
GGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCN
+
@@?FDDDDDFDFDFEGIEGIJJIJDHIJJJJIIJJIEHGDEHFFFFFFD>ABCDDDDDEDDEA:>CCC@CCBDD<<>D>??B9@B(842>>C?BDDBDDD#
@72Q
CCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTN
+
:?BDFFFFHHGHHJJJJJJJJJJJJJJJJIJJJJJHIJJJJJJIJJJJJIJJJJJGJJHJIJJJJHHHHHFFFFDDCDDDDDDDDDDDDDDDDDDDDACD#
@72R
AAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCN
+
CCCFFFFFHHHGHJJJJJJJCGHFHIJJJJIJGIJIJJJIIJIJJJJJJIIJGHHHHFFFDFEEEEEDDDDDDEEECDDDDDCDDDDDDCDBBDDDDDCD#
@72S
CTACATGCCGGAAGGGGGCTGCTGCAACCCCCACCCCTACAACGAAGGCTACGTGTATTAACACAAGTGACAGTCAAGCAG
+
@C@FFFDFHHHHHIGIIIIJBGGIJJIIJIIIGAHJJIHHHHGFFFDDDCCDDDDCCCDCDDDDDDD>CCDDDACDDCCBC
@72T
CTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGNCTGTGN
+
@C@FFFDD?FFBHIIIHIFHEFEGIGIJIADDGCGCGHJJIDHGIGGFGIGBFHI==FF@GHGFA=CCDCECAE>HFDCFB@CCCCCCE(;AC?#,588?#
@72U
GCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCN
+
?;@B;DD1@:BDHCGGGIGD<C<FHIEF<DGEEFDB:D;:8)=.=8=C7))7A)7A3=?@DA:>CCA;>A:@;5;C@C53225<:@AC8+9?3AB>B39>#
@72V
CCTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTG
+
@C@FDFFFCFHHHHIJJJJJJJJJJJJJJJJJIJJJJJJJJJIIJIJIJJJJJJJGGHIIJIIJJIIGHHHHFFFFFDEEEEEDDDDDDDD9=B<BD>B
@72W
ATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGC
+
@@CFFFDFFFHFHJJGGIGGIJGFABDFFDCEDEDDDACC@CDDDDEDEEEDDDDBDCDDDDDDDB>BCCC>@@?:?CDDCCDDDDCCCCDDDDDDDDD
@72X
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTAT
+
CC@FFFFDDDDDDDDCDCCDDEEEEDDDDCCCDDDDDDDDDDDEDDDDDDCDCDDECDCDDDDDDCDDDDDDDDACCBDDDCD@CCDDCACDDDDCDC
@72Y
GCTCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTTTTTCTGGGGACAGCAGATCTGCCAGAAATTGAGGGTGAATGACAGCCTCCACCTTGGAGACN
+
??=DDD;D:ACD:EEIIDF@:A+3<FA1+@):::?9CDDDDDA?DA90B?66(B(.@=8).@=)=@DDF>777;??6;;;@;((5;5;95<95:5>>33<#
@72Z
CTCTTTCTATAGTAATCATTTTTATAGATGTCTCTGGCGAGTCCAAAGTCTCCAATCTTCACTATCCGTGGACTGGTATAGTCTTTCACGGAAACAAGGCN
+
=?@DDDDDHFHH:AFF<FGGHEEH@HIB<@A@<FABEE@C8:?DCGHIHIEEGEGI<FGHEEHEGCHC;@AH>CHC7?@E;);@DC@@;AB9==:??C<<#
@730
CTGCCATGATGGTGGCTACTTGAAGGCTGCAAATTCTCTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTC
+
@@@DDDFFFDHH?FHFGHGGEIIEHIHGHGGGECCFGGGCHIIIGGGGGG8BF==FFGGEEDHF@CEGDCCCECEBEFBBECECCCCCCCCCC>@CD3@
@731
GTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCN
+
CCCFFFFFHHHHHHIJJJJJJIJIIIIJIJJJJJJJJJJJJJJIJJ???BGHIJJJJJJJJJHFFDDEEDDDDEDDDDDDDDDDDEEEEDDEEDDEEDDD#
@732
GTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACN
+
???D?:,=2AC::?E<:<CA:C:@2+<AF<????C810?B;*:9**0?DDEDD16A;7=C7=4A)@4'45?77?6666;;>>A;;;559?=AA3>3BBDA#
@733
CGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCN
+
CCCFFFFFGHGGDIJIJJIJIJIIIJJJIIJJJIHIHIJIJIIJJJJIJJJGJIGGHHHHFFCDEEDDCDDDBBDDDDDDDDDDEDDDDDCDD@DBDDDD#
@734
CTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTTGN
+
@@CFFB4ADFHBFHEDAFHEGHGGGBF<CEFG?CFC9?DGEFHIDGDGIEFHHIIIIIIIFFFA=B>@;CC>C@CCCAC;>@C@CC5>CCDDCCFA5:AC#
@735
GGTCATGTTTGTTCTGTTCTTATGGTTTCCCCACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGN
+
@@BFFFFFHHHHHIJJIJJJJJJJICHHIIJJJIJGDHGIIIJIGHIIJIJJJJJJJJJJJIIGHHHFFDEEEFEEDCDDDDEDCDDDDDDDDCDDDDDD#
@736
AGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGN
+
@@7D?DDDFHHDDFGEGGHIHGIHEGDGGCHHGIIGGIGGIGGGGIHCGHHGIIEHHEIHIGFIEAH>ADDDEEC6@>ACACCCCABAC:@CA@C>ACCC#
@737
CATCCACCGAACTGGGAGCAGGCCTTCCCCTCTCTTTCTATAGGAATCATTTTTATAGATGTCTCTGGCGAGTCCAAAGCCTCCAATCTTCACTATCCGTN
+
:?8:4BD:DDD::<<+A11<A:?1C?*:1B9:99BDD??8999*9B..=8=B@7.>=C)).@;C@.7A7?89',5>A;((935<?>5,,5;>>>:4>>>+#
@738
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
CCCFFFFFHHHHHJGIIJGCHJGIJGHJIGIJJIIIGEGHGGHGHIEGGGEIGHHHFDDCCECECDDCAACBBBDDDCCDDDDDCCDDDCCCCDDCCCD
@739
ATGGGAAGCAACCTTCTGCCCACAGATCACTGGGATGCCCTACGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTN
+
@B+ADEFFGHHHHJJJIIJJJJJJJIIIIGJGIIIJIJIJJJIJGGIIJIIJJJGIIJFHIIJJIJHHHHHHHFFFFFEEEEDDD;?BDDDDDDDDDDDD#
@73A
CTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATA
+
@@?DDDDDHHHFHIIBEB??FBEGEECEGDBFHIIGIGIIIGIHIHIHIGB?GHIIHICHIIICCAACEHGIEIIAHHIIGIH;CCEFFFFFFCCECCE
@73B
CCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACACCGGCCTTTTGTCCGGCTCCTGCTTCCAGCATTGCAGCATN
+
@CCFDDFDFHGHHJJJJGIIIJGICGGFBDHIGHIJJGIHJHGGGIIGJIHHGIJIJIEGIJJIHHEEFFDFEEDDD?BBDDCDDDCDC?CCD(:CCDBD#
@73C
GGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATN
+
CCCFFFEFHHGHHIJJJJJJJJJIEGIIJIJIIIJJJJIJIJJJJJJJJJJIJGHHHHHFFFFDEEEEDDCDDDDDDD@BDDDD@CCDDCDDDEEEDDDD#
@73D
GGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAA
+
?@@FADDBHHHFDHIGIJGGIJGGIICFGEDIIIJJHGHHFFHFDDBBDDCDDDDDDDDAB??B?CDCCACBD?CDD:AB8?CDCDCBDD<@BBBB?B
@73E
CGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCN
+
CCCFFFFFHHHHHJHIFGGJJIJJJIJJHIIJJJJJJJJIIIJJJIJJJJJHFFFDEDEDDDDDDDDEED:@CDDCFEEEDDBDDBDDDDDDCEDDDDDD#
@73F
GTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAA
+
@B@FDFFFHHHHGIJJIIJJJIJJFGICFHGIIHJJJJJGIJJJJJFIJFIJJIIJJJCGEEFF;@CEDEEEDDD?@DDDDDDDDDDDDDDDBBDDDBD
@73G
CAAGAGTGAAACTCCATCTCAAAAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTN
+
CC@FFFDFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFDEDDDDDDDDDDDDDDDDDDEEEEEEDDEEEDBDDDDDDDDD#
@73H
GGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCN
+
?@@BDEDFHFHHGGGHGIHBDHIGHGGC@CD@HIIEC>BEFHCGIADGHGGHGCDF@?FHIEIGGICGIGGECEAB8B7@>@@A;AC;ADCCC@CCCBBD#
@73I
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTN
+
@@@DDFFFHHHHFEGGIIIICGHIIGGIEAHBEHFHGGHGGGCAGF@G?DHEHGHCEHGGFAFG@FEDCCFHCFIFGI7CGGIIGE?HEHFFDFCC@ACD#
@73J
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJIJJJJIJJJIJJJJJJJJIGHIJJJI7@GIHIGHHHHEFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@73K
GGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCACAGATCACTGGGATGCCCTACGGTTN
+
BCCDFFFFHHHHHIJJJJIJJJIIIJJJJHGIBDGIJJJJJJJJIJJJJJJIJJIJJJJIIIJHHHHHFFFFFDEDDDDDDDDDDDDDDDDDDD?BDDCD#
@73L
GTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGN
+
???=?D?D:AFF?DFDCF>F:3:CB94AF<EGC9**:800??FB5=8;B@;@>>@598???ABBBB0?>@:@AB@B((44>A>+:ABBB+::::3+:99<#
@73M
CGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
CCCFFFFFHHGHHJJJJJJJJJJJJIJJJJJJJJJHIJJJJJJJJHIIJJJJ?FHIHIHGHHHEFFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@73N
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCGGTGGG
+
?@:ADDFDHFDFBFEFGAAB@EEHIIIIGHIIIIGECGGHGIHGIIGIICGCHECBGHGIIEHEIIGEEFEBCC<B>?ACC:<4>:>BCCC@@@>5<@@
@73O
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTN
+
CCCFFFFFHHHHHJJJJJJIIJIJJJJJJJJJJJIJJIIJJIJJJGGIJJJJJJJJJJJJJJJJJHHHHFFFFFFEEEEDDDDDDDDDDDACDDDCDDDD#
@73P
GGCTACTTGAAGGCTGCAAATTCTCCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACC
+
@@@DDDFFHGHADBFHIIJJIIJIFJIIIJJJJJIJJIIIIJFHHJJ9@DFGIIDGCGGIJJGHHHFFFFEEECEECEDDDEDDDDACDDDDDDDDDD
@73Q
TGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGN
+
::;BD=A==AAA<EH@A?IGIH3AF@FHB@9?9C@B9DHI<BB<FHCH?HA??B==CHAHI@88C=7C@CC>AEA7@;3?C@C>.;AD@;;-5>BB??@<#
@73R
CTCCCTTTCTATAGTAGCTCGCCCTGTAGATGTCTCGGGCCATCCCGAAGTCTCCAATCTTGGCCACTCTTCCAGGGCCTGGACAGGTCAAGAGGCAGTTN
+
@@@FFFFFFHFHHGBEHHIGEFHGGEBEBFEHGHFHDGIGEHDHGGGGIJIIJIIJIIHHFCCCCEB?CCCCCE@=??BDBA??C?@4@CAAC?<?BBC@#
@73S
CCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCAGCAGCAGGN
+
@@?BDD<BACFDFDB@FHIDHEHIDHBHFABCDF3CGDFFDG@<DHFGFBHGD>FHI@FCGGEIGIC==DE=EH<4=93>CC:>C>@A?,:>ACC9A?BA#
@73T
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGN
+
?;:BBDFFGGHHHGHIIIIIIHIIIIIIIGIIIIIIIHIIIIIHDGHGIIIIIGGEHGGCAFIGHGE?EEBBDDDCECABCCCCCCCCCCCC?BCCCCCC#
@73U
AGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGAAGGCTGTCCATA
+
;=1DDD=BFHFDBGIGG@B?CH?DHGGECHGHCEIDHBFCHGGGAGGD<FFA@GIGEHGB7<;?CCAA<ACC>CDCD@AC?:@A::9?<C88ACA>A
@73V
TGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCN
+
1?14=DBDHFFHFGHIIFI@FFHGHIIIGIHIIIIIIIGIIIIIGHIIIGGIGHHFHHHEDEEECCCCCCDCCCCCACCCCCACCCCCCCC>@BBB<BCC#
@73W
CTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTN
+
CCCFFFEDHHHGFJIJIJGGIJJIIGIEGEHIGJJJIJIJJJIJGIIIJIJJJJJIJIJIJJIIJHHHHFFFFEEECDEDDDDDCADDCDDCDD@CDDCD#
@73X
CTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCC
+
@?@DDDDDHHADFGI:A?DDHEIIIG@HH;CCFEEECGG@FG@FBADGIDDFFCGGIGEGIDGB;CHGH8=<=A;@;>?;@CCC@C:CCCCCCCCC8@B
@73Y
TCTGAAATCTGTCTATGAATGTTAGTCTGTTCTTTTGGATAGCATGAAGCTTTTACTTACTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGN
+
?@+A?DBDFHDHFIIIIGGAIEHHG:FHHEEHIGHIH>GBCGEIIIGDGGIIIGHHIIIIIIIIIGIGG;CEC@GDHHFDEEECCBBCFF>ACEECBBB=#
@73Z
GATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCA
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJIIJJJJJJJIJJJJJJJIJJJIJIIIIHHHFDFFFEEEEEEDDDDDDDDDDDDDDDDDEDEEDDDD
@740
CCGGTACATGATGCTTTCAGGAGGCGTCGAGCGAATGTGGAGAATGGGGTTTCCGCCCACCCTGTAATAATCCGGGGTGTTGACATCTCTGGACATGCCGN
+
+=?B+=)+2C:22<CEE<FAF3+@A11))0)0('-;=))))6)6)7A(;''(.((,,38532((,,55>3>(+)&0&&)&(((+4((+(4(:4<44+>35#
@741
ATGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGN
+
@@?D?DFADAHHHHGGHGCHGHGHIIIIIIIFI?DDGGGEGGIIHIEDFGIHCHFDHHIIII@AAEH>EFBBDCEAEEE6>CB@ABB85?@>@CBCB??A#
@742
TTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCC
+
=@1ADDEDHHHHHJIJJIJJGGIJIIJJHHJJIIIJJIIIIJJIGIEIIJHJJGIJIIFHIIJJJJIAEHHHHHFFFFFFDEDD@BBCDDDDDDDCBDB
@743
CTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGCTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATAC
+
CCCFFFFFHHHHGJJJJJFHHIJJJJJJJJJJJIJIJJJJJJJJJJJJIJJIJJJJIGHIIIGHHIGGGHIJHH?CHFFFFFFFDEEEEEEDDECDEED
@744
CTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTN
+
@@CFFFDDHHHGHJIIIIFGGGGIGEIIJGIJJFHIIJJJJJJIHHHFFFFDDDEE;AABD?BDDDEEED@CDCDD<CB9<B8A@@CDCCDCDDDDDDDD#
@745
CGCCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACN
+
CCCFFFFFHHHHHJJIHEHHIIJJJIIIJJIBIIJJJJIIJJJJJFFIJJJIJJJJJJJJJIJJJIJJIJJJJJJJJIJHHHHHHHFFFFEFFEEDEEEE#
@746
CAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATN
+
;?@DDDFDBBFFBEBFGHIIGGIIIIIIGEGIGEFHIIGHIHEHGGIIIEGDFH:FHIIGGFHGIFBFACA@GAC7@GIHE<EEHFFD;BEDEECACE?C#
@747
TTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCN
+
CCBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJIJJJJIJJJJJJJJIJIJJJIJHHHHHHHFFFFFFFEEEEEEDE#
@748
GTGTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTA
+
=114=A;DBFFFDFIBFEEFFGIF?FFIIIIIDAFEFEIIIIIFFEIIFFIFIIEEEIFFEIFFFFFEFDDDDDDC>@BDBBD@@@BBAB>>ABB@BAA
@749
CCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCG
+
BC7DDFFFHHHHHJJJJIJJJJJJJJJICGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGHIJJHHHHFFDDDDD@CDDFEDDDDDDDDDDD
@74A
TGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGA
+
BB@DDEFFHHHHHJJJJJJJJJIJJJJJJJIJJJJJJJJJJHHFDDDDBDDDDDEEDDDDDDDDDDDDDDDDBDDDDDDBBBBDCCDDDD9BBDDCDD
@74B
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
@C@FFFFFHHHHHCGIJIHIJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDFDDDDDDDDDDDDDDDDDDDDDC#
@74C
CCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGACTTCGGN
+
CC<DFDDFFHFGHIJJJFGIIGIIIGHHJJJG?ADDDEFFEEDDDBBDBDDDDDDDDDCDDDDDBBDBB@DDDDDDDCDDDDDDDDBBDDDDDDDDDDBB#
@74D
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
@@@DAD?BFFFA;;@BAC@FGF6D?DD@9D=FFG@DF9<<D@F6FF@FCE;@D>9?AE88>BB;>@BAABBBB?BA@AA,<?:>>:A@:8<<?A9>AA@>#
@74E
CGACTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTT
+
=@+4BDDFHHHCFFHIJJJJJJJJJJJJJJJJJJJJJGIJJJJJJIIIJJJJJJIIJIGIIIIJJIJJIIIIJFHGHFEFFFFFEFEEEEEDDDDDDD
@74F
CCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCN
+
CC@FFFFFHHHHHJJHIGJJJJJJJJJJJJJJIIJJJJJJJJJJJJJIJJIJJJJJJJIIIJHHIHIIIHHHHHHFFFFFFEDEEEDDEDEDDDDDDDDD#
@74G
CTTCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGACGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTN
+
?@+=BBDA>FDFHGHGGICEEFBHGHIIGFH?FD??CB<DFGGHGGGBFGB-=FC;FEEEE>5=>CA>>;@AA?BD??CDDDDD058@>CABCCB:>CCC#
@74H
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTN
+
???BDDFFHHHHHJJJJJIIGGIIIIGIIEGIGGIGIIJHIIJJJI?FHIAGHGIGG;@EHFHFEDEDEEDBDDDDDDCDDCDDACDDDDDDDACCCDDD#
@74I
CCTTCTTCCCCTGCCCCGGTTATCGGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGN
+
@B+BDDFDHFHDHIJGHGGHHIIJJBHBGHGIGGJJGGIHGG8EEEFHHFFFFFCCEDBDDDD>@CACDDDDDDDDDDDDDDCDDD>@ADB?CCD@CA@C#
@74J
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJBHFDEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@74K
GTTGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BB+ABDFFHHHHHJJJJJEHIJHHIJJJIHHJJJJJJJJJJJJJJJJIJJJJJHHHHHHFFFFFEEEEEEDDDDDDDDCDDDEDDDDDCDDDDDDDDDD
@74L
GTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGN
+
CB@FFFFFHHHGHJJJJHJJIIGGIJIJJGJIJIJGHIJIJJFHIJJJIIIIJIJHGIIJJJJEHIJHFDDDDDDDDDDCDDDDD@DBDDCDDDDDDDDD#
@74M
GACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCN
+
CCCFFFDFHHFHBIJIJJIIJIGIIHGIJIJJIJCGHIJGEHJHIIIJIJIIIIGHJJIGIJHGHHHFFFFFDEEDBCDDDCCDDDBDAB>@CDDDCCED#
@74N
CCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGN
+
@<@DBDDD?FHHFGE<@FHEHIGEGGGHDFH<FBF>BEFFHGIHG<FEBDEHH<CC==CCCHIECGCCEF>@D;B@CCCCDCBBBBBBB9C?:A@CC@?B#
@74O
GCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTN
+
CCCFFFFFHHHHHIIJJJHJJJJIJJJJJJJJJJJJJJJJJJJJJJJIIJJGJJJJJJIJGIIHFGHHHFFFFFFEDEEEDDDDDDDDDDDDDDDD<BDD#
@74P
CTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTGCTCTCAGGCTGGAAGCCTCCCTGCCAACAAAGGGGCAGAGCN
+
?<+ABDADBBD<A<,A<:+3:+3<B;9CAE<9?9??*10<?*:B9*09B?8B*?(=1-(8=====@@A?>/;;;??>A@((5=5;>=8=?3<??.058<9#
@74Q
CGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTN
+
@B<DDBDDDDHHHIBHFGIJJIJHGHGHIJCHHIGIGIEGIGIHIIJIJIIIAGEGIIJIJJJJJEHHFHHFFFFDDD>@C5AACCDDCD<5<3>A@C3>#
@74R
TGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCN
+
CCCFFFFFHHHHHJJJJJJIJJJJIJJJJJJJJJJJJJJJJJJJJJIJHJIJIJJJJJIJJJJJJ;ADDBEDDEDD@CDDDDDDDDDDDDDDDDDDDDDD#
@74S
CTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGN
+
@@=;DDD;CFFHHIGIIGGGDGGGGGIIIFEGGCHCHFGGDGHH<@GEGDGHBHIBGEGIGCHGHE@>AEH>ECBDBCEEEC:>CCCCDECCCCB@BBBB#
@74T
GCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFBEEDEEEEDDDDDDDEEFEEDDDDDDD
@74U
CCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTN
+
?@<4BBDBFFFFFEEEFIDCEB<CFHICF:CG0?GGF?FB>FFDAFDFEFFFIEIEFABDD=B>AC@@A>ABBAAB<@B5@>AB@3@::AA:9??:??A>#
@74V
GTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTN
+
@@CDDDDDFHHHGIGIEGHJGIHHIIIJJHGGGCHHIIIGHGIAGIEHJGII?EBF9BFHGGHHGGIGGGEHIIIIHHFEH?@BEFFCEACECC@?AACD#
@74W
CTCCAGTTCCAGTGACTCTTTCGGTGGAGCGTCAGTGGGCTTTTGCTCCAAGGAGTGCCTGCTCATTTCAAACAGGAGCCAATGGTGCATCCAGCTCTC
+
@C@FFFFFHHHHHIJJJIJJJJJJIJJJJIIIIJJHJJJJJJJJJJJJJJJJJJJFGIIJJJHHHHHHFFFFFFEDEDDDDDDDDCDDDEDDDDDDDDD
@74X
CTACAAGGTCAACCAAGGTGAGTAAAGGACCATAAAACGTTGCCATCCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATN
+
CCCFFFFFHHHHHJJJJJFHIJEHHIJJJJJJJJJJJJJIIJJJJIJJJJJJJJJJIIHHHFFFFFCDEEEEDD?CCDDDDDDDDDDDDDDEEDDEDDDD#
@74Y
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGN
+
@@=DDFFFHHHHHJJIEGIFJJIIJJIIIIJIIJJIIIJGIJIJJIIJJJJJJ?FHHIJIGEHIDCAHHHEE:EEE=@CDFFEEEDA;ACDCDDCD<CCC#
@74Z
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTN
+
BCCFDFFFGHHFHEHHJJJHIJJIJJJJFHIIGFHG?DHGIJJIIJG<FHGJGHIIIJHHEFFFFFFDDA>BDDDDDDDDCCCDCDDDDDDDDDDDACCD#
@750
GTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGN
+
CCCFFFFFHHHGFHJJJJJJJJJJIIJIIJJIJJIJHIIJJJHIJHIIJJJJJJIJJ@DEHHHHGDDEFEFEEEEDDDDDDDDEDCDCDDDEEDCDDDDC#
@751
CTGCTCTCCGTATCCCCAGGTACTAGGGTTTCTCCAGGACCCAGGGAAATGTTGCCCCTGGAGCCCAGTCCCTGGCAGCCTTCCTGATACTCAGTTACACN
+
CC@FFFFFHDFFHJIGIJIIGHHIIJJJJIJIIJJIDFHFIIGHJIIGGJGEGFHIIJIIJGEEEHFFEFFECEDEDBDDDDDDCDCDDCDDDDDEDDDC#
@752
CTCTCCGTATCCCCAGGTACTAGGGTTTCTCCAGGACCCAGGGAAATGTTGCCCCTGGAGCCCAGTCCCTGGCAGCCTTCCTGATACTCAGTTACACACTN
+
?;;D;D@=CDDDDDEIEE<A<C4CE9CE<DEA><))?D;B;D:;(//B=<)=BCD6A26==AC=D.?>@DD@A@>=??AA>>AAA:>>AA>,,5>33+9<#
@753
CAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTN
+
@@<ADBDDBFFHAHI@GHIIIGHIDGHHGC@9?DHEAGGEBA@GGICFGGGDEGDHHGGFECFCDD?FGGIIIIIIHFFF;??ACBCC>BADACC@C@CC#
@754
CTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCN
+
C@CFFFF=DHFHFGHGHHHHIGAFHGHIIIGIGJIIIHDEGHIGGHGGIIGJIGGFDDBBBBBBBDBBBDDCCCAC?ACDDDBBBB>@BBDB><B@BBBB#
@755
CTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCN
+
@@@DDA;DHAFAHBDA@AFH@EFDBCCFFHEFDEC??EBBFHIIGHFGFDCCEHGHIB@FCCEACHHGG@GHAHGGECHEHFFEECEE@DEE@BA;>ACC#
@756
GATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTN
+
CCCFFFFFHHHHFGHIJJJJJJJJHJIJJJJFHHIJJIIJJJJJJJJJJJJJIJJJJJJJJIJJJIJJJJJJJJHHHHHFFFFFFFEEEEDEEECDDDDD#
@757
CTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAAC
+
@BCFFFFFHHHHHJJJJJGJJJJJJJJJJJJJJIIIIJIIIJIJJJIHIIJIIHJIJHIJJJJJGIHHHHHFFFFFCEEEEDDD;?BD9CDC
@758
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
@@@DDDDD<>?FFEFDDGIGI:A<:CDFHIC<CGHGHC@HBGGIIHA8276@@@@CHCHHEA>'08)08@C>C?BB@8>>CC4>>@>@:@ABB<BB?>@>#
@759
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
@CBFFFFFHGHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIEFDDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@75A
CAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTN
+
CCCFFFFFHHHHHJJJJJJJJJJDDDDDDDDDDCDDDEEEEDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDEDDDDDDBDDDDDDDDDDDDDDDDDCDDC#
@75B
GGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTN
+
@??DDDFDFDDHHDFFGHGIGGBHGGHJEIIHEEIGHGHGBGI@=FGGAG@@DEEAEH;?@;>>@>CC@A=@@B<BDDDBCCEEDCDCD:@CCDDB@DDA#
@75C
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJHIJJJJJJJJJJJJJJJJJJHHHFFDDEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDD
@75D
CTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCC
+
CCCFFFFFHHHHHJJJJJJJJJJGIJJJIJJJJJIHIIJJIJJIHIIJIJIJJGIIJJHIIEIIHGHHGHFFEFFFFFDDEEDDDDDDCDDEDDDDDDB
@75E
CCCCTCAGCTACCAGGATGTTTCTGGCTGCCAAGTCCCGATGAACGAGCTTCATCTCGGCCAGATACTGCATCCCCTGTGAGATCTGCCAGGCAAATG
+
@@7DBFFFGHHFDBHIEEGIIIGG2AFHGGGEEBGGEGHGGHIHGEAG@FGDDAAGCDHEFHHFFEFEDACEDCDDDDDDACDDDECCC:>A?ADDC:
@75F
CCTATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
=?+=ADDFFHBFHIHGICHGGGIGI1?FFAAGA?FGIFGGGEHEEEG>@GIIIGHAB=;@CECEACECCCC@ACCCCDDEACCCC::@CC?CC?AC@<
@75G
GTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACAAATCACATCGCCATCTTCACCTTCAAAGCTTTCATTTATGACTCCACTGTTGTTTGN
+
@@BFDFFFHHHGHGIJJJIGJJJJJJJIGIGJIJIJJJJJJIJJJIJGIJIIJJJJIIJJJIIIIIJIIJIJIIJHEEHHHFFFFFFFFEEECEEDDDDD#
@75H
GTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGN
+
?;?DBDDD<<:D@2@8AEBD?EE>:*:???D?DDB9BBDDECBC=D=@;)7==;@;@CCA=7?CD73?A@A:@>>A5>>>ADA>AAAA:;?<AAAAA>AD#
@75I
TCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTN
+
@BBDDFFFGGHHHJIJJHIGHJJJJJJJJJIIJHGIIJJJIJIJIJIIIIIIIJIIJJIIIJIJJIIIJJJIHIIHIGHGGEGHIIHHHHHHHFCDFCFE#
@75J
CATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCC
+
@@@??=?D?FHHBB@AGHBBC?ACCG?GB?9A2CHBFBBGF?CGCGIEH>F@B@G;??DHBHBFCGCHI>=66CH
@75K
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CC@FFFFFHHGHHJJJJJIGBHHIJJJJJJJIGIJJJJJIJJDHIIJIJGIFGHIHGGHIJJIJJJ=CEHHHHF5@BDEEEDCBD8?CDDCDDDDCDDDD#
@75L
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCN
+
@@@FDDDDH>CFHDDDHDEIIC@AHFICHEA4CGDDGHA@:B?6??FCAFDB8==8CBFH@7=C=CEGC;CHA>ACEFFDF@@3;;>CCC@',244@C:@#
@75M
CCTGCTTGTCATGGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCN
+
?@8DDAFDFFFHDHBFGFBIIGIGCHDHEEH@HHAHIIGIEGHGGHIBFDFGGDGCEHEGFHH>FEGIGEAFHIEIIGA=AC;BCFCCED>;ACEC@DCC#
@75N
GGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGC
+
CCCFFFFFHHHHHJJJJJJJJJJIIIJIJJIJJJJJJJJJIGIIJJJJJGIJIJJGIIHHFFFEEEEDDDDDDDDDDDDDDDDEDDDDDDDDDDDDDDD
@75O
AATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFF9>BD?CDDEDDCDDDDDDDDDDD#
@75P
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFFDFDHDHFFEGGGHIIIIGIIAHIIICHDGHAGI@DG7?FG@HGCAGGHGHHCEEHHFFDEFDDD@BBCCCACCA@CCCDDDCDDCDDDD4:@CCC#
@75Q
GCTGGGGTATGGCATATATCCAAGAGAAAAGATTTCCCATAGCAGCACTCCAAAGGACCATGTGTCTGTTTTAGAAGTGAATATTCC
+
BC@DFFFAFHHHHJJJJJJIJJJJIJIIIJJIIJJIIJJIJGIIIJJJJJJJJJJIIJJJJJHIEHIGHHFHHEFFF?BCFEEEEEE
@75R
CTGGGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACN
+
@@@FDDFDHDDHHFEGDGHII>HHEGHGIFGG<DFGHFHIDFGIGHIDGGDHHIBHGIGGGEEGEHHEHFFFFBDD?CCC@A@B=;CCCC@8A<?BCCBD#
@75S
GTCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@@8DDDDFGHHGGHHIIIIIIGHGIIIGIIIEHIIEHEHIFHGGIIGHIIIEIICHIFFGGGGI':BE9@CEECA;@BDDDDBDDDDDDDDDDCCCDCCC#
@75T
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
=?+4:BDD?8DDDID<ACC@8CE892<?CB3D?C>D<BD?):?10?@@(.<B=.=@@AA5(7?C);7;77?@>?=;>>?>>?;?>;>A??><(4:A:A>?#
@75U
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
?;;;;DDDHHHHDEIIIIIIIIGIIEIGG@@FCFEGFEGGGCBB=FCGHI>CCHIIHHHFEB>>A>CACDDD@AC?C@C:;ADD:55;>:ACC?CCBDD<#
@75V
GGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTN
+
@@@D?ADDDFABAG:ABGGII>HFHIBHHHHHIGF?CF@G?:BGBD:?FHD?GD??F>*?7CDEBHB<A;>A>AC>CCA?B@B85-559@AC>85@CCCC#
@75W
CTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATAC
+
??8+A4DDAAD>D@EEE@A<CCA?CDFE;E>C?89??<@3)?DD9?DA<DCB<BBCAC9@:@C=4=CC<@CCDD=3=);>A@@>A@@AAAA>>>;A(;5
@75X
CTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGN
+
@?@DD;ADHHA=CCGGGFD@>A@:DHHCHIIC9BG@GAFG@FHFCEGHC9=@;7=@DHDD>9>;@C:@C@CD>@AC88>B@<?@@BB8902:>8?CC@A@#
@75Y
CCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATN
+
BB+ADDFFHHHHHJJJJJIJJJIJJJJJJJJJJJJIIJJJJJJJJJJJAGIHIJJJHHHFFFDEEEEEDDDDDDDDDDDDDDDDDDDDDDDCDDDDCDDD#
@75Z
CTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGN
+
CC@FFFFDHHHHHIJJJJJJJJJJJJJJHIJJJJIIJJJJJJJJJIJJJJHHFFDDEEDDDDDDDD@CBDDDDDDDEEEDDDDDDDCCDDDDBDDCDDDD#
@760
GTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCN
+
BBBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ=AFHJJJJJJHHHHFFFFFEDEEEDEDDDDDDDDEDDDDDDDDDDDDDDDDDDDD#
@761
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIIJJJJJJIIJJJJJJJJJJJ@GHJJJHHHHHHFFFEFFDDEDDDDDEDDDCDDDEFDDDDDDDDDDD#
@762
CAGGACACCAAAAGACCATACATCACTTTGCGTGGTGTAGATATGATCAAAAAGGGATTCAATTGCCATCCATTTAACTGGAATCCGACCCTGGCTCCTCN
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJJIHJJDGHIJIGIJJJJJJJJJJJIJHJJJIIJJHHHHHFFFFFFFEEEEEEDCDDDDDDDDDDDDDDDD#
@763
CGCAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCN
+
1=1=1AA>FFFFFFGF@:?3A@CCCHICGG<EBFGFFEFEI9DAFGEIFFGFBF<<D?FBD3=FCC;FC4).=CDFEEFFE3?EBB@B@C(6@ABD@;@;#
@764
CTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTG
+
@CBFFFFFHGHHHJJJJJJJJJJJJJIEHIIJHIJIFGIJJHIJJJJJJJJJIJJIJJJJHHHHHFFFFDCEEEDDDDDDCBB5>CDDDDCEDEDDDDC
@765
CCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCN
+
@CCFFFDEFHFHHFIIIJJIIIIGIHJHGIJIJIJJIIIIIGGEGGJGIIJJIJIIIIIGIIGHJIJIIGIGEHHGHHHHHFFFFEEEDEDDDDDCDDDC#
@766
GCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATGCCCATTGGGAGAATAGCAGACTGTAGACTGCTTTGGGATTACGTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJIJJJJJJJJJJJHHHHFFFFFDEEDCDDDDEDEDDDDDDDDDDDDDDDDDDD#
@767
CAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCC
+
?@?BDBBBHFDDHGDGGGGGGGGGEGIGGHGEGIGGIFGEECDAEGGEEEEEGFCE<B>FCECGCGCECBFCGECCHHCC@@EHEEEACEB7@B@DCA@
@768
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
?@<BDD=BC<?BFB?F@FHDEHI2CFG9CEF::CCFGFBIAF(8B*0=<=<BFEFF==)7==AE?BDDA:A?>BB5>A;@A?@?B@<A>@BBABEA44:@#
@769
AAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGA
+
@@CFFFFDFFFHHJIDGGIJIIIIJJJJJJIEIIJIHHFHHHFBFFFFEDDDB@DDDCDCDEDDED>>CCCCCDDDBBBDDAABD>BB2<CDCDDDBB
@76A
AAATAAACTATTTCCCCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGC
+
@@1DDFFFHHHHGGIHIIIHIIGDFGIIIIDGGGIIGIIGGIIIIIICHHIIIGIIGIIHGHFFFFFFEEEEECB?CCCCCCECCCCCCCACDCCC@BB
@76B
GTTCAGAATAAGAATCATCAACACCAAATTCTTCTTCCCTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACAGCAACCATTTACCTCTGAACTN
+
BB=DDEDDFHHGFHHHIHIIIIGGHGIIIJIIGGIIJIIIJIHIJJFGIIGBFHIIJGIIJJJJIIGEGGIIIJIJIGHFCCEBDEFEEEEEEDDDDDDD#
@76C
GTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
@@?DDFFFHAADDGHIGGIEHIIIHIIHIIIHEHGIGIIIIIGDDFCHGGBFCHCGG@AHGIIF@C=DEEH>HGFFFFDAEEDDDEDDCDCBD;;>CCA
@76D
GGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
;@?DDDDDFDBD?CDD;GBFEHGEHIGA??DGHGHGEH@GG?DFGIIFH>CGFGCCEGH>EHADDBB;?CCCCCA;;@CA?@?=?CCCDCCC5>ACCC
@76E
GTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCN
+
@@@F?DDFDHFHFGHGGGIJIIIGGGHJIJJJIJDEEDGIJJHGHJIJIHGIDGEGEGGHJGEFHGGIJIGEEHFFHHGHEFEEFFECECEDCCD>CD@@#
@76F
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTG
+
CCCFFFFFGHHHHJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJIJIJIJJJIIHHHHFFFEEEEEFEDDDDDDBDDDD
@76G
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
BCBFFFFFHHHHHJJJJIIJJJJIJJJHIJJJIJIJJJJJJJJJJJIJJJJJJJJJIJJJJHHHHHHFFFDEEDCDDDCDCCDDEACDCDCDDDDDDD
@76H
GGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCTTTTTGCTTTCTTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGN
+
@B1=DDFFHHHHHIIJIJJJJJJIIIJJIJJIJIIJIFHIJJJJJIHIIIJJAFHJJJIJIIJIJJGHGEHGHIHHHCHHFEBCDDCE@EDEEEDDDDDC#
@76I
GGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTCCAAAAAAAAACGAATGCAAGAACTTN
+
?@==ADDDDHHFFGBEHI@FHHHIIIIIE2AE@GHGBFBDFHIIH>GGEHG?BBDFFBBGG@=FCFGC<AEGGGHAHHFEEC??B'95+8+4@C(<A?CC#
@76J
TGCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCN
+
@CBFFFFFHHHHGIJJIIIJJIJJIJIJJIJJJJJJIJJJJIIJJJJJIIJJJJHGIJJJJIJJJIJJIIJJJJJJGIGJJJHHGHHHFFFFFEDEEEDD#
@76K
GCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCACCTCN
+
CCCFFFFFHHHHHJIJJJJJHHGJJJIJJJIHJIJJJJJIJIIJJJJHIHEEHFFFFFFDEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@76L
GTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGC
+
@?<DDFFFGHFGFGEIGGHIGGIEHHJJJJIGHHIGHHIIGHGGGEGGFGIFIJIFIBFGIBGIIGGGHGFFFFFBFECEDECDDEEEDEEDDDCADD
@76M
ACTCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTN
+
@@?DDFDFHHHHHIII@CGCGHIGCGGGHIIIFIIIIIIIIIIIIIGIIIIAGEHFHHHHEFFFFFECECDECCCCACCCCCCCBCCCAC@CCCCCCCCC#
@76N
GCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACC
+
CC@DFFDDHHGHHJJIFHIIJJGGHJIGGIIHHGGJIJG?::?CDHGHGGJJIGBHIJIHHHHFFFCDDEDDEEECDDDDEDDDEEDDEEDCDCC@<BD
@76O
CCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATN
+
CCCFFFFDHHHHHHIIIJJJJJJJJJJIGHIJJJJJJJJJJIJFHIIIJJIJJJJJJJIJJJJJJIJJJJJJJJHHHHFFFFFFFEDDCBDBDDDCDDEE#
@76P
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
CCCFFFDFHHHHGIJJJJJJJHIIIIJJJJJJIJJJFHIJJJJJJJJJGJJJIJIIJJJJIJJJJI=FGHHEHHHFFFFFFFEEECEEDDDDDDDDBBD<#
@76Q
CTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCAC
+
CC@FDFFFHHHGHIJIJJJIJJGIGDGFHEHIBGHHGIJIJJJJIGJJJJJJIIJJJJJJIJIGIGHIIIJJJJJJJHAHHHGEFFDFFFEEEEEEDDD
@76R
GCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATN
+
:?@DDDDDFFBFFGEGHIIBE@HC?FFGEGIIIHGIBFHGIBGH@38?0?FHIIIG@GGIIIIIIFI<DEIGHCEEFD=D;@CAC3;5;5;;>C:>C(5;#
@76S
CTCATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTC
+
??<;DD?B:DFFBD@C:2<I?E:CGIBAEC<CHDAEE?CEBBF<F<?:C@??B>>AG3DBF@FIAB9=4=CFGFA;F;;F@;=CE=E>;=777ADB?B>
@76T
GTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTCCAAAAAAAAACGAATGCAAGAACTTCATACGTGAACTTN
+
CCCFFFFFHHHHHJJJIIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHDDDDDDDDDDDCDDDDDDDDDDDDDDDDDD#
@76U
TCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGG
+
??@DDDDB13?D?DHHIBEE@>AEGIDCEBH3?D<FEDFD?<FDGIEG99?D66:@AFHII;C=C7==>>7;@?;;ACCDCCC5;ACCB?AB>AA>CB8
@76V
TCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTN
+
?@@D1=ADDDAF?F@G?GHGIIIIEECADD<F;FC?BE?D<CHEGIGEHHIGCHGGE>GI9DH>@GIECBFEEG@DC=CD7ACAEE?BB@;?;@CCCCCE#
@76W
GCCCCTTTTTGTGTATTATTATTTAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGCN
+
CCCFFFFFHHHHHGIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGJJJIIIJIJJJJJJJJJIJJHIGHHHHHHFFFFFEDDDDDDDDDDD#
@76X
GTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJIHHJIJJJJJJJJJHIJJJJJJJJHJJHIJJJJJJJJJHHHHHHFFFFDEEEDDEEDDDDDDD?BDDCC
@76Y
TGGGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGN
+
@@@DDDD<?D?FFAGFFFB;:CA3AH@EG9FFBC=??0?BDF@DDFFIC;FAFD=CDFAFEF=@ECE?EAC<?59A;ADBDBDEA>;>@>>BBAAAAABB#
@76Z
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGN
+
@@<DDDFFHHHHHIJHHIIIJJJGGGIJIJIJIIJJJJIJIJIHHIJJIJJIFJIIJGHHHHGFFFFFFFCEEEEDDDD@BBDDDDDDDDDDDDDECDDD#
@770
ATGCAGTATGACCTCCGGCTGTGTGTGTATAGAATTTCCAGGGGGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGN
+
<?@D?DBDHHHFDH?CGE8A@CFA?:???DFCDBGHI@BB<GD)75@@?ACCCC3>@:::A77@BCCA;?BBBBCCCACCCCCCACCCC>>CD>CCCCC9#
@771
GTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGN
+
CCCFFFFFHGHHHHIJJJGGHIJJIGIIJJJIJJJJJJHHHFFFDDDDDDEEDDDDDDDDDDDDEDDDDDCCDDDDDDCDDDDDDDDDDDDDDDDDDDDD#
@772
CCTGAACAGAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCCGGAAGTCTCCCAGTTGCAACGTTAGGTGGGAC
+
?<@D7DDD>DBF<EHEGEEEGIAGCBFHDDBHGGIGGHGBHB@FA?D;CGEDGIFIC=@C@@AEHFBA@;?;C:@CCACACCCCCAA>A?ABC@@<<<A
@773
GAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATN
+
@@@DDDDDHHHGGIIBHHIHHIIBHIIIIGIHIGIIIIGIIDGIICHGIIIIHGIIIIIGDHIIIIIEHHGF?DFEEEEEECCCBCCCCCCBBA?ACCCC#
@774
ATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTN
+
CCCFFFFFHHHHGJJJJJJJJJJJJJGHHFHIIJJJJIIHIGGIIIJJJJJJJJJJJJIJJHIJJJJJIJJJIJHHHHHHFFFFFFEEEEEEEEEDDDDB#
@775
GGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATN
+
@C@FFFFFHHHBFIIIFHIHIJJGJGHICGHIIIFFHIJJIGIEGGIIJIGIIIJGHGDHIIJJIICGCHIIH=CCEHF>CDF>AACCEEDDBB@BDDCD#
@776
GTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATAC
+
CCCFFFFFHHHHHJJJJJHJJJJJJJJJJJJJJJIJIJJJIJJJJJJJGHGHIJJIJJJJIJJJJJJJJIJJJJJJHHHHHHHFFFFFFEEEEEEEEEE
@777
GGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTN
+
@@<BDBDDABFHDDHHIGD??EIIIIIEC9EFHI6???GBGEDD9D;FHGIICCEFDGIGCG4==EE;CGIEE;=A=ABEB??BDCC?6,8<ACC@(4>@#
@778
CTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTN
+
@C@DDDDFHHHHFIJJJJJCHJGGHIIJIIIFGIJJJJJIIJJJIJJJJJIJIJJIIIJHJIIIHHIIJJIIGEIGI7CHFHHDFFFFEDECEEACCCCC#
@779
CTGGGGAAAGCAGAGAGCATCAGAGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTC
+
CCCFFFFFHHGHHJJJJIJJIJIIIJIFGHHIHIJIIHIIIIIJJIJJIJJJJJIJJIJJIHHGHDFFDCDDEDDDDDDD<@BB9>BBCCDD>CBBBD
@77A
AGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGAT
+
CCCFFFFFHHHHHJJIJJJJJJJJJJFHIJJJJJJJJJJJJJIJJJJJJJJJIIJJIJJJJJJJIJJJJJJJHHFDDDDDBDDDDFDDDDDDDDDDDDD
@77B
GGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCN
+
@<@DDFDDDABFDEFEHGGGECHI@GEE??DEG@GGIIHII?BFHBHIIHBGFGEHBB07@>AA?DBCCBB>?+:A9??CCDDCCC?CCDDCCBDDDDDC#
@77C
CCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGN
+
??<DADDDHFFHAG;EHGGEDH@BHHHG@HA@FE?DADF@AFDHCGIIGC=@=<=D>=BDDED:>@CCCCACAACCCCB888<@C9>?@?BB59<CCCC@#
@77D
CGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJ=DFDADDDEDDCDDDBDDDDDDDDDDDDDDDDDDD#
@77E
GCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCC
+
@@@DDFFFHFHDFEDBEGHIIEHHEHIIIBCHIGGBEGHBEHHBAHGHIIIIDGIII=FG@BGAHEFHCFG@CAGEC2?EHEBBDCCEDECCDBDDECA
@77F
GCCACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCA
+
@@@DDDDEHFHGDCEFGFGIII>HIGIIIHGHIGIIGICDDDFGEEFGIIIIIIIIGHIIGHHHHEEFDDDCCCAAC?AC>CCDCCACCDC>CC@@CCD
@77G
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
@@7DDFADHHHHHIIJJJIJJIJJJGIHIIFHIIJIJIJIIIJIJIIIJIJJJJJJJJJIJJIHHFFFFFDEEEEDCDCDBDDDBBDDCDD@C@CCCDD
@77H
ATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
=:+BAADDF<CFBF<EF@9C<@?E@;<@<8?BEC419????D9?BBG9?D2BF>0C;F/,3,(5>;;;>A;,;>@B9?<5>:5-09<AB:3>3<AB:A
@77I
CTTCCTCTGCTTCCTTTTTCTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTN
+
BBBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIIJJJJJJJJIJJJJJJJJJJJJJJIGHGIJJJJJJJJJJJJJIHHGHHGHFFDDDECDDDDDDDDED#
@77J
CCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTC
+
@@@FFFFFGGFFAHIGGHIJJGIIEIJGCGFFHGGEGHJHGHIJJIICBFDGIIJGIJFEHGHIGE-=DFDECECCEB>ABC?=AADADD@CC>>C@
@77K
GTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATG
+
BBBDDDDEHFHHHIJJJEHIIHIJJIJJGIIIIIGIGGIIIJEIGGDGIGGIIIGDGGIGGHFDCBCDDCDDEDD@C@BDDDDCDDDDACDCDDBDDDC
@77L
CACAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
=?+=BDDDHGGFHIGIDHIGHGH@?F?FGGIDHGBHIIIDCHIGHGGH@AHIGHHFFDFDFEECCECCCCDACACDDDCCCCCCC:?CBDDDCDDAADC
@77M
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJJGHIIJJJJIJJJJJHHIJJJJJJJJJJJJJJJIIJJHJJJJJIFHHIJIIIHHHHHFFFFBEEDCEDD5>?BCDDDDDD8?C
@77N
GTCAAGCTCAACAGGGTCTTCTTTCCCCGCTGATTCCGCCAAGCCCGTTCCCTTGGCTGTGGTTTCGCTGGATAGTAGGTAGGGACAGTGGGAATCTCGTN
+
@@@DDA:AABBFFAGE2ACCBEEHH<CG<CGG@BBD<?0BDF=6BBF4.=DE)=).?E1@D@;;@:@9>@=9ABB,5>5(55((32(2A438898A>B(2#
@77O
CAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCCTGTTCTGATTTAAGTACN
+
?@<D4ADDHHDD?EBGGA@B1)6<@CC?@?8CBB><@CC?<?ACACCCC<CCCCCC?<@<BBCCC@CC:>4>@C>C>@@@4>@CCCCC>@:CCCCDA>A:#
@77P
GCTGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGGGGTN
+
@@1BDDBDHFHFF<CAGGFGGCGIG>GGGIIIICHIIHFDFBCEBDACBFGHDCCEH;6@GGIHGHE?ECEEHEBEEECCCCCACCCCC?BBCBBB'090#
@77Q
AGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTN
+
@BBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJGIJIJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJGHHHFFFFDEDEDDDD>A@DDD#
@77R
CTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJGIIJJJJJGJJJJJIJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJIIHHHHHHHFFFFFFFFEDFEEEDDDD#
@77S
CCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGN
+
@B+ADDFFHGHHHJJJJJHIJJJJIIGJJJJJJJJJJIJJIJJIJJJJJJJJJJJFHJJJJ?EFFFFFEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@77T
TGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGAGATTCTCGAGCAGGTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATN
+
=??D7?B=CD18C1<AABC:?<9CEB<<4?9?1??4:**1*?B<9D*@)(./))8)7;8''.(677?7)=))7?1((.>A>6-;;;3;>;;3(5:>:3;3#
@77U
CTCTGGCGAGTCCAAAGTCTCCAATCTTCACTATCCGTGGACTGGTATAGTCTTTCACGGAAACAAGGCAATTTCTAGCTGCCAGATCCCTGTGAATGA
+
@@@FDBDFFHCFDHGGEHHIIIIFEHGGGHIGFIEGG?DHDFGII?BBFF=FFGIEHI=@HG==AHBBBBC>A>ACEACA>??C@ACDDDD<:@DDCAC
@77V
CTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAG
+
B@=DDFFFHHHHHJIJIJJJJIJJJJJHHHIIIJJJJJJJJJJJJJJJJHJJJJJIHIJJJIJJJJIIJIJJJJJJJHEHHHHHFFFFFFEEE
@77W
CTCCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGN
+
1?1=ABDDHDFHHE<CAEHB?DGIE==FHIGEFHIEECHFFB>=>>;;@@BACCCC>C@>CA@CC>@@CCCCCCCB?8AA?@C@@C@ACCCBABCBCC4@#
@77X
CTTCCCGGGCCTCAGTTTCTTTATTGAACAAAATAAAGCATTGGAATAGTTCATCTTCAAGTTCTTTCACCTTTGATATTTAACAAGTCTCTACTTGATGN
+
B@?DDFFFHHHHHJJIJJJJJJJJJIJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJJIIIJJJIJJHHHHHHFFFFFFFFEEEEEEDDEDEDDCDD#
@77Y
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCN
+
@@+ADBDDBFDBDFBDHHGIIIIIIIIGGIIIIIIGIGIIIIGCHGIIIEGHI@C8B@FGHIGCHGIG>EEA>;C@BBB@;?6;ACCAC>AC@CCC?B9>#
@77Z
AGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
@@@DFDDDFHHDHEBFHIJJAEGFH<DAFBFHFFHIIJ9DG9BG@FHIHIJIJICHGGIDEIHHFHGHFFEFDACEB?=ABD@DDBDDDDDDC@?BDD@
@780
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJI@EEFEEEECDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDD>A#
@781
AGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATN
+
@@<DBBDFHDAHHIIGGGGHGDFCDHIIIIIIDEGGGGGHGIFFIGHGFGIGHIIGICFGIBHGFFHIGEGEDGFEEBDFCECECECECB=ADDCDBBDD#
@782
CTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCN
+
@@@FFFFDHHGFHIEFGGHGIGEGHIGI@GHIIJIJIJJGGGIIJEHJHHHHFFE@CACCD?CDDDD@CCDDD?B<B9@BDDDDDCDCDDBDDDDDD9<@#
@783
CTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTN
+
@@CDFFFFGHHHHJGHIHIJEHHJFIHIIIJJHGIJJGGEFAHHGGGGHIIHIDFIGIJJGIDHHIGGIIJIGIIJJJJIEGEHIIGIJHHHFHHFFFFF#
@784
GTATGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAA
+
==1=ADDDHHHHF@GHGIIIEBEEDG@DEADGD:FD@G<FGGG8:88CCCDD@@C:BCCCCBB?<57&55@:>C@AC?CCCCCCC<?BB>BBBBBBECC
@785
CCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCN
+
BB:BDFFFDD=A<CFGHHIJJJJJJJJIJJJJJJJJJJJGJJJJJIIIJJJJIJIIJJJJJJJJJJJJJJJDHHHHFFFFFECCEEDCDC>C@CCDDDCD#
@786
CAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTC
+
@C@FFFFFGHHHHJJJJJJJJJJJJJJJJIIJJJJJJJHHHHEFFEEEEEEEDDEDCDDDDDDDDDDBDDDCDDD@BD<ADDDDDDDDDDDDDDDDBD
@787
CTGGGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATN
+
@@@FFFFFADFHHIGHIIIIIJJJIJIGIGIIIIJIJJGGIFFHIJJJIIJJJFHGIIJIEHJDEGIHEEHHFFEDEEEEDDDDDEDCEDDDDDDCDDDD#
@788
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
B@<DDFDFHHHGHIGHIJJJJHHHHIEHJIIGIFGGHIIIJIHGJIIFHGGHIJJIGIJJIJJIHHECHFFEDEC@CACDCDDDB?BBBCCACCDCDED
@789
AGTTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGA
+
@?1ABDDA<FDHCDFFHGIGBF>ACFHGHCFEHED?BBGCBG>GGIGGEEIGGGHEFAGGHIGH=D=??CECFBD>BACCC>?C>>CBBB??BBBB?99
@78A
ATATACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCCTTTAGCACAGTGATTTCN
+
1114ADDDDDFD8CA?ADHHHHIGIE@HAFHIIIGFGHB<<??FBFHGIFGIIICFH:@FDHGCAHFHFDE77);AC3.;,3,;@AC@CCCC?@CCDEEC#
@78B
CTTAGGCGGAAGGCCTGGAGGACCCTCCTGGCTGACACCAACAGCCTTAGAGGGCAGAATGGTCTTCACATTAGATGCTGTCACAAATGGAGGTGCAGG
+
1:+ADDDDDDAD?<E@EE?DCC8???;D99*0/6BB==;C;1;6.=?CDC=7@D859=A5>>(5>A:(,,5::>A:,,:4A>34>42:>4>28+8>::>
@78C
GGTGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGN
+
1::442AAFHFHHHIJHIGIIJFIGIGHIJJIJJJIIHICCHIIJJHIJGIIJIJGHIHFGEHF@CE?CECECECDDCDDDDCDCDEDDDDDCCACC:AC#
@78D
GCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACAC
+
@@@?DDDDHBHABCDEGHIGBEHBGCFGB?FEH?GEBFH=FHHCEHIIGH<@EGECHCEFFFFFEEECCACCCDCCC:>?C?>9CDDCCC@?B?BDDD8
@78E
CTTCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@@+ADDBDDHHGDGIJFEHHHEEGIIHHIGIEDAFHGGIHCBGHFGIECFHIJJIE;CG==EEHF>59;>CACCCAB?B?BCCDDDCA>@::>?B@>BB?#
@78F
CCTTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGGGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTN
+
@@8ABADBBBBAFE<C?F@?CBAFH<AFE?GIA:DD?:?@)7@D;8CCFBBCGAG84AB?@>;1',288?>C>;@DE>?AA393>?C<:4:::@AC@B9C#
@78G
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@@1DDFFFHHHHHIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHH=ADDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@78H
TTTCTTCCTTCTGCCCGTGACAAAACTGTCACACCGCCTTTTACGAGGCTGTGAGGGTCGAACTACTCCCAGAGCTAGGGGTTTCTCCCTGGGGACCCC
+
=@=?AD>DHDDHD@<:EE<1C?CFBACGGH<?9?@FGGGGIICHEEHIAF@6@=;6AE7=816=;>CA>59@<9>:>CBB@BB?@CCAA?CBBB?>@@?
@78I
CTTTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCN
+
?@+DDDD?F<CFHIG;C<AGG@HID>:CAA<??HHIBHC@??C1??BGEDB??9?BFFDFHBC@@FHIGGHG@@@@ECHEC>>?BEEE@@CC@CCCC>8@#
@78J
CCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGN
+
@@@DDB>=C?FFAE<D?@:DFACG8?D??DBB<4BBFFIB=CDFEE<B8BDBAC@@>@B>@ABBAA@@A>?8<ABBA:A>AABA:ABBBB-559>A@4@?#
@78K
TAGCTCTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGN
+
?;?DD+ADADDF?DFFHI@DADHEH:<E?BEH9C@CDBGDDGGEGH?DDDGDGBA;FB5=3@CCCCA@CCCCCCCCB?::3<>@B@CCC?CCB>>CCDEC#
@78L
GAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGG
+
CCCFFFFFGHHHHJJJJIJJJJIIIJJJGGFHIIIJHHIJJIIIJJJJJJJJIJJJIJHHHHHHFDACDDDDDCDDDDDDDADDDAC?@BDBDDD<BDD
@78M
CGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTN
+
B@@DDDDDHHHHHJJJIJJJIJCFHGIIFIJJJDGIHJJJJJJJJJJIIJIHIIJJJHHHHHHFFFFFFEEEEDEEDDDDDDDDEEEDDDDDDDDDDDDD#
@78N
GATTTGGAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAAT
+
@@@D<DDDD>FFBF<CG<BHEFEGE><CHHIIIIIFADGFFIF@AGFIFEAFDE:<B<DFGEEAEFF@FAEFIEFE@DE>CF;?BDD@;BAACCCCBB?
@78O
GCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTN
+
CCCFFFFFHHHHHIIJJIJIJJJIJJJJJHHIIJIGJJIJGHGHIGIIJIJJJJJJIEGIJGFHIGGIGIIIJIIIHHEHJHGHHFFFFFCEFEEDCEDE#
@78P
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
@@@DDDDDHDHD:2@@FHEG<GAHBFC=;FGEHGEFHGGGHEGHGGHGGHIIGECAECEDEEEEECCCCCCCCCACADCCACCCCABBB9@BACCCC@A:#
@78Q
CGACATCGAAGGATCAAAAAGCGACGTCGCTATGAACGCTTGGCCGCCACAAGCCAGTTATCCCTGTGGTAACTTTTCTGACACCTCCTGCTTAAAACCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJHFFDDEDDDDDDDDDEDDDDDCDD?ACCEEDDDDDEDDDDDDDDDDDDDDDDDDD#
@78R
GCCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJHJJJJJIJJJJJJJJJJJJJJJJJJJHIJJJJJJJIJJJJJJJJJJJJJIHHGHHHFFFFFFEE
@78S
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BB@FFFFFHHHHHJJJJJCGHGCGGIJJJIHIGIJGHIGJIIJJJIJGDHGICHGHHHGFFFFE@CCCCDDCCCCCACCDDCCCDDDDDA@@BBBBDDD
@78T
CTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGN
+
CCCFFFFFHHHHHJJIJJJJJJJJIJJJIJJIJIHIIJJJJJIJJJJIJJJJJJJJJJJJJJJGGHJIJJJJJJJJJJJJJIIHHHHFHHFFFFFFEEEE#
@78U
CTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
B@@DFFFFHHGGHGIJJIJJJIEHIIJJIJIIFGHIJJJJJGEGIJHHHIJJIJJJGIIGIJHHHHFFFDDDCDCCDDCCCDD=BBDD>ACDCCDDED
@78V
AGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGN
+
?@?==BDADD?BDFHGAAFHFGHIEFGIICEH==CEIGIHH-5?>;@AC@A>;ACCCCCCC>C?<?;ABB?BBB9>@2<A<9:C<@BA<?BBBB<BB9CC#
@78W
AATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATN
+
CCCFFFFFFHHHHJJJJJJJJJJJJIJJJJJJJIJJIJJJIJJJJJJIIJJJHJJJIJJJJJJJIJJJJJJJIJHHHHHHFFFFFFEEEEEEDDDDDDDC#
@78X
GACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAAT
+
@?@DDADBCFDFBFGGIIIGIIIIIGGI9>GHIICGGGIEGEHHG?FGGHIBGHIAHCAFEHIIA@EHIIIHHHHHHCDCDDDC@BB@;?C@5,:?BBC
@78Y
CTGGGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCN
+
@??BBBADH?DF>F?EB4;ECFFHHG+<CEHG?*:8??FHI?@G@BF7BCD@7=;DFAG)7)7;;:;>CCEEC@C:@??;5>CCC>:A<ABB??(2:??B#
@78Z
GTCCACCAGGCTTATTGAAGCCACCTCGCTCTCCAGCGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCN
+
CC@FFFFFGHHHGJJJIJJJIJJIJJICGIIJJJJJJJIIIFIIJIJJJIJFEHFFFFCEEDDBDDDBDD@BCDDCDDDACCDDDCDBDBDDDDDDDDDD#
@790
GTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGATGGGCCTGTCTTCAGGCTGATGGTGCCAGCACTGAGTCATTATCCGGTATACAGGCN
+
;??D;?DB+C?:AAA4,AEAEF34:392CE<;9C>EE*::CDE***0?;0((/9@CE:)8=;6@)=).)=7?C1A2737);(;>A>@AA<>'8=A:;A?=#
@791
AGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGG
+
@@@BDEDDHHHFHEFGIHHHGHIIIIHB=7@;@BDDD89BBDB@BBDDEDEDDDDD5@BDDD<<B?CDD@:CDDC@@@CCC>BB9BDDDDDCBCCCDD
@792
AGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATN
+
CCCFFFFFHHHHHJIJEGIHIJJHIJJJIJJJJJJJJHIJJJJJJJJJJEHFFFFFFEEEEFEDDDDDDDDDDDDDDDDDDDDDDDDDEED@CDDDEEEE#
@793
CCATACTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATN
+
@@@DDDD?B?CAFEBHEFHI@EGHIGIHDGGIIIBEECCFC@FGACHHG@GIGHGHIIGGGIIEIEIGHIIGHAGGI>DHEHHBEB@CEBDCACCCCBCC#
@794
CAGGTCAAGAGGCAGTTTCTGGCAGCAATGTCTCGGTGGATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGA
+
@@@DDDDFHDFDDGEFGGIIEDBEDHIIIHIGBEFHCDFHIIG@D?DD?FHHGIIGGGGAG@HGCDEAHHEHDD@??AAAC@CCC?8;=;CCBBBBB@C
@795
CAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGN
+
@CCFFFDF:CDHHIJJGIJIGGHIIICHGIJDIJJGHIIJJDAFHIEHIIJJFCHGHGCHHHFFFFEEECEDEDDDCC@CDCDEDDDEDCDDCDDDDACD#
@796
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
@?;BDDDBH<BDFAB;FGI<EDED@<93CGADGGD;FECA@?;0-;CGGHII<;;)=CDD>AB?CCC@CC9,55>@>A:@@BC<AA>C(8@B8ACC3>A@#
@797
CCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCCAAACTGGGAGTGCTCTCAGGCTGGAAGCCTCCCTGCCAACAAAGGGGCAGAGCCTCTGN
+
@@@DBB;:=F4DFEDGAA<ACGII<AAAGEGIIDD<??CFB?BBBGGF@(07088=F@FE;@@@=;=D?EACBDBB(=BABBBBBB@??=B@?89<A@BB#
@798
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CC@FFFFFHGHHHIJIIIIIGJIJJGIHHGHJJIJJJFHIIHHGIJIJIIIIJIIIGIJJJJJGIJIHHHDE?CCEEC@CDDDDDDDCCCDCDDD8?@B
@799
GAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTA
+
@@<DDDDDHDBFDEHIIII<HHGICEEHGEHIIIIEIHIIIEEBDCEC>CCB<BDACC,:?5,:A>A@CCDCEDDDDDDDCD>@BCBDD?CACCD@>@A
@79A
AGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACN
+
@?@DFFFFHFGHFIJJJJJIHIJIIJJJJJJJJIJIJIJJJGIGIIJJJJJJIGIAHHIIGIIIJJJJJJJIIJJJIIJJJJGJEHGHHHHFFFFFECED#
@79B
CCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTN
+
@@1BBDDFGBFFDGDEHGCFHHGHIHCAFHEHIGIIIEIGHC@GIGI@GHDBGC<BGBEDHI>FCA@FG@CF>CACE@AAE<<BBAEE@ACDEECACCCC#
@79C
CTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGGTTN
+
=@+BAA???CCAFAEBBFG@ACGHIIIECGCEGEGHIIIEEEGDD?DFBFHIIEGCCFIGBEI?=<=DCCCCCCFCCCCCBBB<??B?9BB@CC?BBBBB#
@79D
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
@@@FFFFFFHFGHGIHIIGGIJJJJGHIGEGIIIJHIEGIEGIJCHIJIEHIIIIIGGGIGIGGGIIJJHG/=A@DCCDEDD@>?BBBDBDDDDCDDDDD#
@79E
CTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCN
+
?<<?;DD;=:A<D)<)AEE<EDE?E@<9??@D<DBDDBDDD88=BB3.@C9;@CD<>>A@D=AAA:>;A?=>??AAAAA:AAAA>>:A4:>;902:AA>:#
@79F
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
@@?DDDDD?FHHHIIIIIEIEHGGICHHGEHI:DFHIIIGCHICEGC@EEHGHFEEHEDDEEC@CCCCCCCCC?CCCCCCCCCECCCCCCCCCCCCDC@>#
@79G
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCAT
+
CCCFFFFFHHGHHJJJJJJJJJJJIJJJJJJIJJIJJJIJJJJJJJIJJDDDDDDDDCDCCDDDDEEDDDDCDDD@BDDDDDCDDEDDDDDDDDDDDE
@79H
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
CCCFFFFFHFHHHJIJJJJJHHJJJJIJJIJIIJJJJJJIJJIIHIIIJJJIJHHEHHFFDDBDDDDDDDDDDDDDDCDDDDDDDDDDDDDDBDCDC@CD#
@79I
CTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGTTCCGTTGGCCTTN
+
???D=D==AD;DD>A2:AF@+<3C@9A9AFCEIIII@?D??90??B?CI9CEIEEII>D=).=C3AD;?AD>;7;7AAAA>;A;,''',(,'442+44:>#
@79J
CCACACTGCTTAAAGAAGTCTGCCAGATCATCTAGAGTCACACTGTCATTTAATCCTTGTACATAAATTGCACTGTTGTCAGAGTCTTCATCTGGATCT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJHIJJJJJJIJIIJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJHHHHHHFFFFFFFEDEE
@79K
GAGGCATCCTCAGTCCCCATGATAAGGAGATTGCCTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTTTCTAGCAATGN
+
@@?DDFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJIJIJJIJJIJJJEHGGIJJJGHIGHIJJIHHHHFFFFDDCEEDDDDDDDDDDDDDDDDEDDDDDD#
@79L
CGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTN
+
CC@FFFFFHHHHHCGGIJJIJJJJJJJJJJJIJIJJGHIIJJ@GEHHHHHHHHFFFFFFDEEEEDDDEDDDDDDDCDDDD@@BDDDBBD>BBBCDACDD>#
@79M
CAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFHFFFFFFFFDDDEDDDDDDDDDDDDDDDDCDDCCDDDDDDDDDD@BCCDDDDDDD#
@79N
CCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAGCCATGGGGGTACCTCTGTCATCTCCCCACATGGCTCCCGAAGAGCCTTCCCAGGGAACTN
+
?;:4BD3++:+A<ACFAG63C+ACE@GGF@FD*:*9*?D*0*::D*9B@F'577=)==?)=7).)7.9@3(..,=(;?(',3'0((89349(4(+)(8+:#
@79O
TAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGGGGTGACTGTN
+
@@<DB2=DDC8BAG@;FABFFGH9A?GHGIBFHE>DEG@FHAEE?B?F2BD.84=CCHF@DG>A=;A>=??B;BD@@A>@B?5@@B?,22&)))02:@A3#
@79P
GGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTN
+
@@1BDDDDDHHFFEGHGEEFFGFHGEGIGGIDHD@DHEEFBDDDEFCCEECEAC@CDDDC>>A?@BBBD>?B>BBB2<A??CC??B>B@DD<>B<BB<AC#
@79Q
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
?@@FFFFFHGHHGJJJIAHIIEGIGGHIIIHGGGJJJIGEGDHGIIIIIJIIJJGIIHGIJGHEADFDFECA?EDDDCCCDCDDDEDCDDDDCDCCCC?
@79R
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
CCCFFFFFHGHHHJJJJJJJJJIJCHIFHIGIIIIIJJJJJJIJJJJJJJJIJJHHHFFFFFFEDEEEEDDDDDCDEEEDDDDDDDCDDDDDDDDDBDDD#
@79S
GTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTC
+
@@+BDFFFHHHHFGIJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJIJIJIJIIIIHIJJJHHFFFFEDEEECCDDCDDCDDDDDDDDDDD
@79T
TTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGGGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTN
+
@@@BDDBDFFDFFBGGFG:+<FHFHEIBHE@HEH@GFFF8@)8BAGBFI@CEEFEBBF=CFD<CEE-7?B>@CC;A@=;;;>A>AABABBBB@A3>@BBB#
@79U
GCGGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
==+4A?D:<A2A?CECEEFIEAEEIII:DD9?DDD?8?D*?=B)B=CD7@ADEC)@)?CD=?>)?>A@AAA>@A>(5>?>??=AAA>(:A,:>A(44>(>#
@79V
AGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGG
+
;=@DBDDDAH>@:FDBFF@EGB?:CFA?DGAGEGA9?FB?BBCHI=HBEEDE@B;>6>>66>>@@A>;@@CCC@C?C@ACCCCCC@@>CC@9<9>?@C@
@79W
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
@C@DFFFFHHHHHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJHHHHGHFFFEEEEEEDDDDD;@DBDDDDCCDDDDDDDDDDDD#
@79X
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
@@?DDDDDADF8FHGHIHEEGHIBHIIGEGHAHGIEHEGFEFHIHIGGHIIGIHEHH<CEEFCCFD?B9;?BCCCCCC>CCC@AC?CCC@CDCCACACDD#
@79Y
ATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCN
+
?@@B;DDBFDFDHCGEHEFFHGGBEDEF9CEAGEDA@DFHHIGIADFGHBBFBDEGGI7CGHAGCHAEBCEC@DE7;BC@CC@C@>?ACCCADDC5>A@C#
@79Z
GTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCN
+
?@1ADD?D;CDFDFGEE?CHHFHAHFFAFBDFEE@?GDFCDFBFDEFBDEIIE@CBCFFII9=E;A?;C>>>?7;@BCCBBB?;5:@B>AA:3:>>:ADB#
@7A0
CTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGG
+
@@<DDD=1<8:CBECGF<C??9:CEFIEBGBD?D=F?D=CBC@DF@)8=CEADECE<A@EC?D?;?BC;@>@>ABBB??@>A33:9@@AB@B?@B0590
@7A1
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGN
+
?@@B?BDFHABFHAFBEHHEHIIIIIIHIHIE<HEHGGIEDEHGIBFAGAFHICFCH<CF>FH=@EE-=?DCDDE9;;;5>A>5>CCACBBCC?A@ABB@#
@7A2
AGGCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCT
+
=@1A;BDD<CFA>>AE;C33<<BDEF@BCHHHECCCFIFEGFFFFECEI@DFIIIIIIFFIGDFFFG>BFEAFI@3@EFEFFF3?;?@BCEE@@A;@@A
@7A3
AGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCN
+
B@@DFFFFHHFHFHIIIJJIIJJIIJJIIIJJHHIJJJJJIGIBGIJJJJJGGGHJIIGHIJJHHHGEHEEFFFFFEEEEDEECDDDDDDDDDDDDDEDD#
@7A4
CTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCC
+
@C@FFFFFHHHGHIJGHGJJIIJJJFGJGIEGFFGGHIIJICGHGIIDGIIIJGIIIGHIFGGIAGHGF:<DACCEEDDDCCDDDDDDDDDDDDDDBDB
@7A5
CACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCAATATTCAAATCATGGTGTGCTGACACATCATGTTTACTGN
+
CCCFFFFFHHGHGJJJJJJJJIJJJJJJJIGIGIDHIJJJJJIJJGIJJJIGHIIIJGGIJJIIJJIJJJJJJIJIBDAGIIJJIIGHGHHHHEFFFFFF#
@7A6
CCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTCTGGGTGGTCTN
+
@@+ABDDDFHHFHGAFAHBHECHEGGCHEB@FHDFHCBDCFEDAHCHIFHIHHHIIG@B==BFGCF;FG=@DHEHFHFEDEED>7;@@CCCCCC5;=;@C#
@7A7
GGGGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
==14ADBDDHFDHIFFHCHIHHIIIDHIJJJIIJIFGHGICCCHGIJII@2BFCEIGGIHI@GHIFEEHHFFDDDDDDCDCDD>?C>@@CEDDDD:@CB
@7A8
GGGGTCTTGCCAGCAAAGCAGTAGTTGGGGTTGTAGTCGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTN
+
@@7BDDFFGHHHHIIIIEE>DF@HHHIIIIFHGHGIIIIIIIIIIGIIGFGIHIG4AE?BABBBCCCCCCCCCCCACDDCCCCCCBBCACCCCCCCCCCC#
@7A9
ACCAGCACCAGTTTGTTGAAATTGAACTTGTAGGTGAACCGTTTCCCCTTGGTCTTGTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTC
+
@@@DDDBDHH?CFE@FEB>E?FEBGGIIDFHHHIGEEHIIGFHIGGHIIIIGHIHIHBFHEGB;F>DABHEHB@?D?B@DCDD>A>BBBBB@@@B@9>B
@7AA
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CC@DFFFFHHGHHJJJJIIJJJIIJJIJIIIJIIJIJIIJJJJJJIJJIJJJIIIEIJJJIJJJIHHHFGHHFFFFFFFDDD3;BD@CDDEDDCCDBBDD#
@7AB
GTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGN
+
@B<DFFFFHHHGHJJJJJJJIIGHIIJJIIJJJJJJJJIJJJGIIJJIIJJJJJIJJJJJIJJIIJIHFDDDDDDDDDDCCDDDDBDBDDDDDCCDDDDD#
@7AC
CAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCN
+
@@@DDFFDGCDHFFHIIIIHIDFGIDHGGIIIIIGIIIIIIGDFHIGHIGGGHIFHIIEHGEHFFFBDEBCEACD@CCDCDDDDDDD9ACCDDDCCCDDD#
@7AD
GTTGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGN
+
:?:AABDDHFFDAGGGEGBHEHFEHIIIIIIIIIIIICHGIIIFIIIIIEIHIIIIIIIBEG?HGIGHFHEHEEC9>>BCCCCCC:?C:@CBC>CCB:>A#
@7AE
CGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCC
+
@@@DDD?DF?F?;D+A2C@FGH?FFGC*:9CBFC@>3CDGFF>A9D?9938;<;@FCGA(;EEDBED6.>A(;,55;?@>3)09049<<-8?8@C:4>3
@7AF
GGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGN
+
C@@DFFFFHHHHDHIIIHGGIIJGHJIJIJIIJJJJIJDFHIEGIIJIJEIJJHIJJGJHIJJJJHHGAHHFEFFFFFEDEEEDDDDDDDCCCCDDDDCD#
@7AG
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
?@+ADBDDBDDFFFGGGE@FHHICHHCE?FHBGGHIF@DHGFFGIFI@DFEGGIGGDC>GGAFFHCGEGIIIEIHHHCE;?ABCCCCCCDDCCCEEC:
@7AH
GGTATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGN
+
1:14==DDDDDAFHDGHGDBFFHI<CFIGI<<FDHIIDG>DHEGGCBDGHHIIIICGHGIID8FCEEEC>EC?=?CBFC,9>==>CCDCC:>B?BB<?B?#
@7AI
CCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCN
+
@@@DDDDDFBBD<F<EFFHDDHG<FHHEHIGIHIGHIEHIGGIGGGIGICGGD@B?FF>FHAGDHIIIGI@GAHGHIEHEHAEEEEDEEDDBA.66=?BB#
@7AJ
GGCTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCAT
+
@@7;BDDDFHDBHGBBH;DEGCHHIIGAAGIIFI)??A;CGFACC;@GEEGGEFFEDD@>ACCCCACCCACCCCCBC:@C<AC>ADCCCCCCCC:ACC:
@7AK
TGGCTGCTGGCAAACCTCAGAGGCCAGGGGCCCTAGAGGATCAAGTTTCAAAGGGGTTGCAGGAGACAGGCCCTGAGACCCATTCATCAGCTGTGTGTTCN
+
C@@FFFFFGHHHHJJJIJIJJJJJJIIIJJJJJJJJIJJJJJJJJIIJIJJJIIJJHHFFFFFDDDDDDDDDDDDDDDDDDBDCEEEECCDDDCCCBDCC#
@7AL
CACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTN
+
CCCFFEDD>D<ADGAGHHHIEHEGHGHIGIGGHGGHGIGGICGIIIIG@GGGGGFHBBB@EE=A>A@BFFBA@AACC@;?@;@AACCC5>A@@CCCEA@>#
@7AM
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@@+BDDDDHHHHHJJJJJJJJJJJJIIJJJIJJJIJJJJJIIJIJJIJJJHIIHHHFBDCCCEEDDDDCDDDDDDDDCDDCDDDCDDDDDDDDDDDDCD
@7AN
CCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTN
+
BBBDFFFFHHDHFJJJIIJJJJJJJJJJJIIJJJJJIIGIJIJJJJIIIJJJJJJIJIJJJIFGIIJJGHHHGFEFFFEFEEEECCCDCCDCCBDDDDDD#
@7AO
CTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCN
+
=@+ADDBDFHGHGHBHHGGIIEHGEGBF?DFHIIIIIIGIIIGGHGIIHIIGIIII<:BBFECCBBB;BBCCCCCCBCCCCB@BB:CCCCCC@BB@BBBC#
@7AP
GCCTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGN
+
:?1=ADDDHHDDDHBBAGFHIGB@EFHIIIH@:BFGFFHFGIGFGGECAEGHGGHHHEF;@BCDDDDD55?CACD@?BC>@89+2?@@CACDDBBBDBDB#
@7AQ
CTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGN
+
@@@DDDD>D+4CDFIEFBHBFHHI<F@CEH@H@?D9CFD<E<;FBDF<BFA<BFGIIIGG<D@FGIEIGIIIII>FF:DEFEIFFCCED@BB;B>@;6>;#
@7AR
TTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCN
+
?=?DDDDDFDFHH@EBGHIIIGGGGICGGBAGE>?FHHIIDHIGIEAHIIHIGGCGIIIIGG>FCGGHIIHEHIIIIIDHE>CHEDD@;@CCCCCCDCCC#
@7AS
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGN
+
@@@DFDDDDHGA7FFGIIIIEE<EGHIIGGIIIIIHFE<BD>9;@CACCCDCCCDC@CC@CDDDDCCC>CDCCC?B@BACDDDDDACCCDDDDBDAA@+:#
@7AT
CCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTN
+
=81:1?2??CFFFBG>CFEE@EFB@3A<CAB?EBACFBGE<9?:DE>FFFDFB@<F49DF=2@BF;8;6@C?==?EA?DD@BB;6;B;33>AADBA;;@A#
@7AU
GGAAGAGGACAAGTGCAAGCCTATGTCCTATGAGGAGAAGCGGCAGCTCAGCTTGGACATCAACAAGCTCCCCGGCGAGAAGCTGGGCCGCGTGGTGCACN
+
CCCFFFFFHHHHHIIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFDDEEDDDDDDDDDDDDDDDDDDDBD<BD8?CCC#
@7AV
CTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCN
+
CCCFFFFFHHHHHJJJJIJJJJHJJJJJFHIJJJJJIJJJJJJJJJJJHHHHFFEDDDEDDDDDDEDCDDEDDDDDDDDDDDDDDDDDDDDDDDDDDBDD#
@7AW
CCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTN
+
CCCFFFFBFBFHHJJJIBAFHJGIGHIJIIIGHGHGIECGGGIJIGIGIIIECH<FHIIGCHGCHG;=CC?A>?E7;;@BDB@@CE@.-;>A@CC(5?@>#
@7AX
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@<@DDDBD<DFFFII<AC8A:FDEBCGCF<GCBD<:DFEEF@DD9??BF<<??BFBBFGEDFAFDCF@;B6=B;;@B;3>;??A@AB;595:><@:8@(
@7AY
CTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCN
+
?@@D?DBDDHFBB9FHDHGGIF@3AFEGEGH@FGIIEGCCFBHGIIIII@GHIG?DH:'7@F@AGD473@AHFHHC?@;BDDDDC@C@CCCCACCC?C@B#
@7AZ
GGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACN
+
@@@FFFFFHGDHDIJBEHGEHGJIIJGHIICHEHIGFGHGFEHHEIHFGHIIJIJIIIJIJJIGIIIEIGIBEHDDFDCC@CCCC?BBDB<>9???CCCC#
@7B0
ACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATAC
+
<@@DDDDDHBFHFCAEHE@F<HGG:AAC9<9CE9:?*C@F?CCF?BCEAD=??DC2B898/.=C=;)6857=ECD;;.7CHEDDE;ACDDC=>2>C;;
@7B1
CTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCN
+
@@@DDDBDHHDGHJJGHGHFFHIGIIJGIJHHGGEFEGGGHHIFDHIJJGGEFCDBDDBBDBDBDB;?CDCCCCDDAA?BDDDBB@BB9<@DD>B9@39@#
@7B2
GTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGGGAATTTTTGGCAATGN
+
@=;BB?DDAD:CFBEEBHI=CA?AA?F?CCBGBDHBHDBGHHCAB?DGDF@GD@@A;;;;==CHHADEA;;65ADC3;;5>,8@')558@@C4<5:@>CC#
@7B3
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTG
+
@B@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJHIIJIJJHHHHFFFFFDDDDDDEEDEDDDDDDDDDDDDD
@7B4
CCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJIIJJJJJJJJFHHIJJJIJJHHHHHHHHFFFFFFEEEEDEDDDDDDDDDD#
@7B5
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
@@CFFFFFHHHHGFGIJJJJJJJJJJJJHIJEIIJJJJJJJJJIGJJJJJJJJJJIJJJJJJJJJJJJJIJJJAHFFFFDEEEEEEDDEEDDDDACDDDD#
@7B6
CGACATCGAAGGATCAAAAAGCGACGTCGCTATGAACGCTTGGCCGCCACAAGCCAGTTATCCCTGTGGTAACTTTTCTGACACCTCCTGCTTAAAACCCN
+
CC@FFFDFHHGHHBGEGHIJHEGGGIHEGGIGH>EGIFGIGGGHCED<ABCDDDDDDC@CDCCCDDACDCCDDEEDDCCAAACDDCDDDCCCDCDDDCDB#
@7B7
GGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTTGCTGGGGTATGG
+
@8?DDDDDFF??:2<1E@BFBFEGAGE@:FCGCFFF9B?BFFCDFFFFIE>EFFAEA;?77;;>BDD>BCCC@?,3>><
@7B8
TTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATN
+
CCCFFFFFHHHHHGHIJHJJJJJJJJJJJJJJJJJJJIIJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJHHHEHHHHEHFFFF#
@7B9
TTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
CC@FFFFFHBHHGJJJJJGEEIJJGIICIIIGHGIHIJGIGGHGGHJIIGGHJIIJIIJJIIA@FHEIJIJEHHHGFF:CEDCAADCBDB38?@@DDCD
@7BA
GGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGN
+
B?=DDFFDHHHHGJJIJJJHIJJCHGIIIJJDHIIIHGGGIJIIGIEEHFGGCHHIIGGIIJJIIIGEFFAEDBFFFDEC@CCCCCDDDCBDDCDCDDDD#
@7BB
CCCCAAAGGCGCCATGGCCCAGACCCCGAATGAGGGTGATGTTTTTCCGCGGCACCTCCTTCAGGTCACTGATGGAGGAGGTCTTGCCAGCAAAGCAGT
+
+=?DDDB:B<1@DC=FHBGAFDEDABAGEGCHEDHEBB@888@CAGHIDE8<9>>8>9?CC>3:5,:>>@C>3::+8<2?>23>:4:9+4<?CC>C99:
@7BC
CCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGN
+
??@BDB?DDFHDHBA@F:<?<A?<AFFFHG6&07<>CC8<(833>CBD@@A<39>B<<5<A2+:AC@>@43>>::>A:CCAC:9>05<<ACBC?3::4>9#
@7BD
GTTGAAATTGAACTTGTAGGTGAACCGTTTCCCCTTGGTCTTGTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCN
+
CCCFFFFFHHHHHJJJJJJJIHIJJJJJJJJJJJJJJJGIIJJHIIIIJJIJJJJJJJJJJJJJGIIIJJJHHFFDDDDDDDDBDDDDDDDDDDDBBDEE#
@7BE
TTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTG
+
<<@DB::AFFDHA@AFFHHEIIEGF<H9ABCBHEFC:EHHGID99??B*??B)8BD@CCDFECGHFHGH>C==DG>E>=EA>E@>>?BB6>@@AC
@7BF
CCTCAATTAAGGCCAAGGGATCTCTCTGTTTTTCTGGGGACAGCAGATCTGCCAGAAATTGAGGGTGAATGACAGCCTCCACCTTGGAGACAAAGACCTTN
+
CCCFFFFFBHHHFGHHJJGGEHIJIGIHGIJJIEHGGIFBB=FEIGGIDIIIGGHEHGHHGIEGI;AHFHDCDFDBDCEDCDBBDDDCDA?CDDCCDDDD#
@7BG
CTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTN
+
@@@FFDDFFHFBFGGHIEHHEH@HH>GHBAG;CGHIGD<F?FHIHCEABHIGFFIIGGGIGGGBGDFFDGHIEGIIIF>A?ECCDFFFFDEEEADCEDCD#
@7BH
CACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCC
+
CCCFFFFFHGHGHJJIIJJIJJJJJJJJJJJIJJJJJJJJIIJIIIIJJJGGIIJJIJJJJIHIJJJJIJJJJIIIIJIJGHHHHHFFFFFFEDEDEEE
@7BI
CCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCTGTGCATCCCTCTGGGGCTATCTAGGGCTTGCTCCTGCCCACCATGCACTTCTCTTGCCCGTTTN
+
=@+=ADD?FDDFFBHGGEDHHDGGGGFGEHHGGGHII@DEHHFEGGIDHGCE@BHHCE>AH?B@>A<AECCC>CBC@B8<CCC:A>@A>CCCACCC@<AC#
@7BJ
GAAAGCAGAGAGCATCAGAGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTCAGAAGTTN
+
@@@FDDDFHFCFHIIGIGIGII8CGCCGHIIIGBHFDBDFDHECHCDH>=FBGIGIG6@>EHG(=A@DDBCCCB1,9==28<@@C?9+9?B@<??:4?:C#
@7BK
CCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATN
+
11:=??D?ADD>?E@E@:F??4FE?FFEE>FIIEIE<?EDBBD9?<@*0??DCCDECEAB>DA**??<BCDDCDEEII@AC;A@C..773=.7?BD3).6#
@7BL
GGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCN
+
CCBFFFFFHFHHHJIJJJJJJJJJJJJJJJJHIIJJJJJJJJGHJJJJJJJIJJJJJIIJJJJHHHHHHHFFFFFFFEEEEEEDDDDDDDDDDDDDEDDD#
@7BM
AAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCN
+
CCCFFFFFHHHHHJJJJJIJJJJJJJIJJJJJDHIJJJJJJJJJJJIJJJJJHIHHFFDEFEEEEDDDDDDDDDDDDDACDABDDBCDDDDBDDDDECBD#
@7BN
CTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGN
+
CCCFFFFFHHHHGJFHIIIJJJJJJHIJJJJIIJIJJJJJJIJJIIJJJJJJIJJJJJJJJJJJIJJJHHGHFFFFDDDEDDDDDDDCDDDDDDDEDDDD#
@7BO
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
@C@FFFFFHHDFHGGJJJIGJIJIIJHGIEHIBEGGGIGE<?FGIJJIIIIIIDIIIIJJIIIEAGHGGIE3=EBDFFECAEEEDEEECDDD>CB?B<BB#
@7BP
CTTCATCTTCCGCCCCTCAGCTACCAGGATGTTTCTGGCTGCCAAGTCCCGATGAACGAGCTTCATCTCGGCCAGATACTGCATCCCCTGTGAGAGCTGCN
+
@@<A?D>==?CFA@1@A@E?99?G>G>1)??90BGGG@3BGAG@?8*/><AHII:C).-''5@;(.6@;.5(935(,,(5>:@C::88(++::(:(++9?#
@7BQ
GTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGC
+
CCCFFFFFHHHGHJGHIJJJJJJJJJJIIJJJJJJJJJJJIJJJJJJJJJFHJJJIJJJFHIIJHIJHHHFFFFFDDDEDDDDDDDDDDDDDDCDDDC
@7BR
GCTTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
??+AB1D=C1<;C@EEEIFCEEFEDEIIDDD?DDIEDDBDEEIDI@DECDEEECD@ADCCD@CDDDDD@@A?>ADA:;;>???=>?>>?AAA>9A9>B>:#
@7BS
ACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATC
+
@@@DDDDD@@@FB@EHIGHEFHA?FDBFFGIIIDCDGIII<=CEEDGAHEH;EEHE>E=;BEECCBB=BB@B:ACCC@:CCC:AA>CCC?CCCCCCCCC
@7BT
CCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
CCCFFFFFHHHHHJJJHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIIJHHHHHF=ADBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCD#
@7BU
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
??@;DB=BBFDHHEF?EF3CEGGHGI<GGG?DHCHGIIGIIIIIIIIAEIGGEECFCHEEEEDECCCCCEACCCCCCAC>CCAA:@CA>@CBBB@<?CC
@7BV
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTN
+
@@@FFFDFHHHGGJIIIJIAEGFGGHIHIGGIFHIHDHEGIEHHIAGCHIHH=CG@=CHGIJIIIHGAEFFFE@DCCC@BB;;@CDCDDDCDDDD:@CDB#
@7BW
TCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCN
+
@@<DDDFFDHHH@BDHGGCHGIIIIEGGGIIGIIIEG?FFHHDHHIGIIIIGGGIIIIIJHHIEGHGIIIIJJGEHHH?DFECAAC@CCDDDDBCBCB?B#
@7BX
TTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTTGN
+
CCCFFFDAFHHHGGHIIIJIGIGGGIIJBHGGHHGIJIFHHIGGII?DHGHHGIIIIHGGCGGGGGBDHHJIJIIIIIJIJIHIJHHHGFBDCC@ACEEE#
@7BY
CATATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGN
+
@@+=ADDEHHHHGIJIIGEGGIJJJGGIGDHHIIIIJIHGGIGGGHD?B=BCCCC<<?CCCCACDCD3<CCC>@CD>@CCB@DDCCCDDD9B>4>AA??B#
@7BZ
CCTTGTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTCCTTGCAGAGGAGCCAGCTCTGCAAGTCCAGCATCC
+
?@+ADABDAHD>F>BDGE4CHHI@HEEG<A;?E@GFDHHIBHCFBDHA8?G?88/?8DHFHA@@GC@CGGEHHHC>@;.;?>>@;6;5
@7C0
GTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTA
+
@?@D@DDAFDDDF??@,<;E=>FCF<EHIIG9<EHIIC*9?FGB?DFHGIBH@BFB@BGH@8;@ECHG;CAEEC@AA?>@CB@>ACACBB=B?<09@C
@7C1
ACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTN
+
=:+=BDFFDHFHDGBG@EECGEHECGHHHGIIFIII@FHGIEECHIIGCECGHC7;=C>?BCDFBCC@D>>>CCCCCC:?<<@C<CCBCC>>C4>CC>CC#
@7C2
GGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTN
+
CC@FFFFFHHHHDHIJJJJJJJJJJJJIJJJIIIIJJJJJJJJIGHGIIIDFGHIJJIJHHHHFFFFFFEEDCDDDDDDDDCDDDDDDDDDCDDDDCDDD#
@7C3
AGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGA
+
@@BFDDDFHHGHFHIIJIJJIJJJIIHHIJJHFHFGGHHHHHGIHIJIIJHIIHIIGBFHGIJIJJGHHJJJIGIIJJJIIJJEHEHFHHFFDFFFFAC
@7C4
GAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCN
+
CCCFFFFFHHHHHEGIIIIJJCFHIGIIIIJJDCGGIHGIJJIJJJJJJJJJJJFEHIIIHHHHF@DFFFEEDDDDDDDDDDEDEEEDDDDCDDDDEDDD#
@7C5
GCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTN
+
@<7D=@<AFAFHFHGGDEE@?@AA3AE@FBH@>D??F>4BDHBEDFB@:<<ADHIBEC;CA?;8?BBBBAB(4(4@CCACC<?B<9<9094<>CCCCCC@#
@7C6
GTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCA
+
@@?DFFFFHHGHDHJJJJIIJJJJJIEFIIIIJJJJJJIIIIJJJJJIIJIJIJJJIIJJJIIIJJJJIJJHHHGHHFFFFF?ACDEEEDDDDDDDEDD
@7C7
AGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGTCN
+
CC@FFFFDHGHHHIHHIDGEHGHIIJIJJJJJIJJIJJJJJJJJJJIJJJJJIJJGJIIIJIEHIJGJJHHHHFFFFFFEEEDDDDDDDCCEEEECDDCD#
@7C8
TTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGT
+
<B8DDEFFFHHHHJJJJJJJIIJIJIGJJJGHGHIJJJIGIJIHJIIIJIIIIJIJGHIJJJJIIICHHHEHGFBFFDEEECDEEDDDCCDDBBDCCC
@7C9
GTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCTTAAATTATCTTTAAGTTTTN
+
?=;BBBDDABDD3BEE>2<+ACFBEC<FE>ACCEEE93??D?D4?*90??<<?))?39?B/9*8?B)=..88@=;)@D)=)7A@=@>.==>;AA3.?B7?#
@7CA
CTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCN
+
@C;DFFFFHHHHHJJJJJIGJJIIJJJJJIJJJJJIJJJIJJIJCHIJFJHIGIIJGGEHIGEEHHGHHGFFFFFFFECEEEDDDDBDDDDDDDD;:;5>#
@7CB
CAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGGCACAAGTATCTGCTGTN
+
@@7DFFDFHHHHHJIJIJCGHHIIGIIIJGHGJJCDFHIJJGIJIIGGIJIJIJJIGIJJIJJCGIGGGIBHHFFFFFEDDEEDDDDDDDC@CDDDDDBC#
@7CC
GGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGN
+
CCCFFDFFHHHFFGIJIGIIIJJGFHGIGIJJIGGHHGHIIGHIEIGIIFIIJIIFHHHEHFBDECDCCCE@@CCDDDD<CDAADDDD?ACCDC:@DDDD#
@7CD
GGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGG
+
CCCFFFFFGHGHHGIIJGHHIIIGIJJIIIJICGHJJJJGHIGGHIJJJIIGHIGCHHIACHHIJJJIJGIBGGACHHFHFFD@;@CEEDDCCCADCD
@7CE
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
CCCFFFFFHHGFHIJJIIJJFGIJJIJIJIJJJJIIIJIJJJJJJJJJJJIIJJGJJIJIGHHHFFFCEEEEEEEEDECDDDDCDDDCDDDDDDCDDDDD#
@7CF
GGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACTGATCGTTTGTGCCCCTCCAAGGGGAGGACTTTTN
+
CCCFDDFFHHGGDGIJIIJIGCFHGHIIDECGIIGGGH@GIJEGIEFHEDDBBC@CAACCDADECC>ACACBCDD@ACDDDDDDDDDCDDD>BBBDCDDD#
@7CG
GCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGN
+
BB@DFDFFHHHHHIJJCFHHIJJJJJJJJIJJJJJJJIJJJJJJHIJJIJGGIJIIJJJJJJJJJJJJJIJJJJJJHHFFFFFFFDDECCCDCDDDDCDD#
@7CH
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
@@@?BDADFAFA8FF<<::A?:3AE<11:?BDFBF>DDEICF>?F)8C/8=@@4;CEEEF7?3=3?37@@D>@((.6>;?BB5>A@B<A@:@ABABA(:+#
@7CI
CCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGAC
+
CC@DFFFFFFFFHIEHIIIIGIGGGGGGIEHI?CHGHEHIGGIIEHGIIIIIIIGFHGECGGF>E;=/9?9<CC>@CCD=???BCDDDCC
@7CJ
GGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGN
+
CCCFFDFDHHHHGJHHJJJJDGHJJJJJJJJJJJHHFDD>BDBDDDDCDDEDACDEDDBBDDDDDDDDCDCDDDDDDDDDB4ACDDCDDDDDDCDD@CCD#
@7CK
AAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTN
+
@@@FFFFFHHGHHJHJIIGGGIGIJJIIIJJCGHIGHGIIJIIIIE9BGHHIIHIHAHDHEHIJGEGGGIIHHFHHH@>@?>CCCDDED;@CDDC>CCDC#
@7CL
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFFFFHHHHHIIIJJJJJJJJIJJIJJJJJJIJJJJJJJIJIIJJJJJJIJJJHHHHHHHFFFFFEECCCDDDDCDDDDDDDDDDDCCCDDDDDDD
@7CM
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCCTAGGTTCCATAGCTTTGTTGCN
+
@@<AAA?DCDFD?FB:?EDA??E>GHGFB9<D*9DH3099?FCD8B9=FCHAGGDGA@CC>;?HCDEE>;CB169;>A(;(,::3>@@B>(5>>AA:<8A#
@7CN
AGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATC
+
@@+=D?DDDADFD?AGHEDDHCEEHCABHAFGHEGBC:1:?:DAGDFGCGFHC@F>8D;F@@GIEEDHEHHHFC?DDEC@C@=CC5@CCD@>ACC@@@>
@7CO
GCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCN
+
B@:BDFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJGIJJJIJJJJJJIJJIJJGHJHHJIJJIJIJIHGHHHHFFDD?CDCDCCDCCCDDCCCDD#
@7CP
GGGCAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTN
+
CCCFFFFFFGHGHJEGHIIJJJJJIJDDDDDDDDDD3?CCDDEEDDDDDDDD8?@BDDBDDCCCCDDDDDDDDDDDDCDDDD><<AC@@A?AA::??:C:#
@7CQ
TTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTN
+
CCBFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJGIJJJJHHHFFDDDDDDD-?CDDDDDEEDCCDDDEE#
@7CR
CTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGN
+
@C@FFFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJIGHIIIJJJJJIJJJJJJJJJIIJJJJJIIJJJIIJJJIGHHHHHEDDEFFFFEDEEEDDD#
@7CS
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@@@DFFFDFFBDAB?BFHHGGIIIGGIIIIFHIEEIIFGEGEHIIIFGIIIDDHIIGCFGIIIIBAECA;A@ACC;CBABBBBBBB:@CBBCACCC@@AC#
@7CT
GCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCN
+
:B+=ADEFHFHFHIHIIIIIGIIIJIIIGHGHGIGIIIJJJIIH:BDCACDDEEECDDDCDDDDDBDDDBDDDD?DDDDDD>CDDECCDDDDCBDDBB<C#
@7CU
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
@C@DFFFFHHHHHJJJJJIHJJJJJJIIIJIJIJHIJJJJJJJJGIJJIJJJJJIJIIGIGJGHIIIIFHGHHDEFFFDEEEEEDBCCDDCDD:@CCDC
@7CV
GCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGT
+
CCCFFFFFHHHHHJJJIJJJJJJGGIHHJJJJJJJJJJJJJIJJHJJIJJJJJIJHDFDEEEEDDDDDFDDDDDDDDDDDDDDDDDDDDDDDDCDDED>
@7CW
GTTTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTN
+
?@8ADDDAAH:C<C?CD;<ADCHIGIGHH<9*:CFHECCHGIIG>BFEIIGGBFHC@F>A>AGDD7?)=??@DD>@DCCC@CC;(;;?BC?B@(35<@?>#
@7CX
ATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGAAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGN
+
;:1=:2=2=?,+A<?DDE?EAC3AAB<F?+2CE;*1)1111*9?0:6?)0?:55&)883<=88=38>9(+4>32+9>:A(:A3+4(:9:2()00(:A3>A#
@7CY
GTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTN
+
@@?DDADDABHFDE;EFED;@FHGDDEEGEGHGDGIFFHIGFBFGA<F@?BCH<B@FHGIICHHGFHAAE>DDE@@@@CBCC<B?BBBCCAACCCCCCCA#
@7CZ
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
??@FDFDFFHGHFGIIB@BCCBFHGGEEGBFGFFH@F?EGABEGIGE;8EAHCD;7?@AC>CCCDB@CACBB@@BC9@CDDDDCCC>ACA@ACDEE@>C@#
@7D0
GTTGGAAGCCTGCGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGGGCN
+
@CBFFEFFHHHHHJJJJIJJJJJJJJJJIJJIIJHHHHFFDDDDDDDDDDDDDDDDEEEDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDCDDDD#
@7D1
TCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACN
+
@C@FFFFFHHHHHIJJJJJIGIIJIJIGHIIIJJJIIIJJJJIJJJJJJJIJHIIIJJIJJJGIGAEHHHFFFFFFEEDCCCCCDDDDDDDDDDDDCDD>#
@7D2
CCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTN
+
CCCFFFFFHHFHHJJJJJJIJJHIEGGIJJIIJJBGEIIJFHIFGHIGIIJJFJJ@DGGHGHGGHFFFFF@CEDDCBBDDDFDDDCDDDEDDDDDDD<CD#
@7D3
CGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGN
+
C@@FFFFFFHHHBGGIIICCDFGGJGIHHHFHIJIEIIHID7BEHEHIIIJEGJHHHFECCDDCCDD>BD8?;@BD@ACDD:CACCCB:<>CCDDEDA:@#
@7D4
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
@BBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJIJJJJJIJJJJJJJJJ=DDBEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@7D5
CCAGTTCCACAGAGAAGCCCTGCTCATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGN
+
?@<DD:BBDBFDC?FG;BCFFF@FHBHE@AFHFHI>FHDB<D@GFHEFHIGE@DBDDF@DDECFHG=B8=@C@C==@GGGIFEHE?EEEEB>BC;@6>CC#
@7D6
GCAGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCN
+
:B+4ADFFHHHGHJJJJJJJJJJJJJIJJJJJJIJIJJJJJJCGHIJJJJJJJJIIJJJJIIJFHIIJJJHHHFD@BDDEDDDDDDDECDDDDBDDDD@D#
@7D7
TGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTN
+
@B@DDFFFHHHHHIJJJJJJJJJJJJJJJIJJJJJJJJJIIIJIJJJIIJJJJJIJJJJJJJJJIJJIJJHFFFDDEDDDDDDDDDDDDDDDDDDDDDDE#
@7D8
GTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTC
+
BBCFDFFFHHHHHJJJJJJJJJBJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHHHHFFFFFEEE
@7D9
CTTGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
=@+AD2BDFHH@=FHIGHGHIIGDGHCFGHIIIIIIIIIIIIIHHGGGIHIIIIIIIIIIIIIFGHE?C?D@DDCEEECCCBBB<@CCCC:A:?CDC:C
@7DA
CATAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGN
+
=@:ADDEFHHHHHJJJJHHIIIJJJJJIJIJJJIIIIIIIJJJJJJJJIJIJJJJJJJJJJJJJJJJIIJJHGHHFFFFDEEEDDCDDDEDDDDDCDCCD#
@7DB
TCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATA
+
BB+BDFFFHHHHHJJJJJJJJJJJJJIHJJJJJJIJJJJJIIJGJIJJJJJJHEHHFFFDDEECDDDDDCCDDDDDDDDDDDDDDCDDCCDCCDDDDCD
@7DC
CTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCN
+
@@@DDADDHH?FBEGEGACFHIAFFAHBCBFHEGF?EECG?GFHIIH?HGBF<;BA7BBBFDA@FHGE@ADCHEHECCCC5;>CCCCC5:>5:@CCC@;4#
@7DD
ATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGA
+
CCCFFFFFHHHHHJJIJJJJJHGIJJJJGIJJJJIHIIJJJJIJJJFHIIIJFHGIIIJJIIHHHHHHHFFFFFDEEEED=CDDDDDDDDDCDCDDDD
@7DE
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGGN
+
??@DDF+AFFDDHIIIBHGEHHHGIDHIIGDEE@GG*?FGCFHI@HCGH?FGGGIEAF@FEC:BFF8@GAE:AEH>DB@?CEECE3;6>?A@C@BB?=B&#
@7DF
TCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCA
+
?@?DD:ADFFDHFHHGHIGJCCFGGCGIG<<<:EFGIGIJIHGHIHIGIGJ@GAEEEEHH@DDFDFEE@BDEEDDDCCCACCCCC=;?@D?:ACAC?8A
@7DG
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
CCCFFFFFHHHHHJEHIJJJJHIIJJJJJJJJJIJFHIJJJJJJJJJHFHHHFFFFFEEFEEEEDDDDDDBBDDDCDDDDDDDDCCDDD:ACCCEEEEED#
@7DH
GGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTN
+
CC@FFFFFHHHHHJJJJJJJJIIJJJJHIJHGGCGIIJGHFFFFFFEEEEEEE>ACDDDDDDCDDBDDADDDBDD(<@BDDDDDDDDDDBDDD9><CCCD#
@7DI
CTGCTCCTTTTGCTTTCTTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAA
+
CCCFFFFFHHHHGJJJJJJJJJIJJJJJJJJJJJIJJIJJJJJJJJJJJJJJJIJJIIIJJJJJJJJJJJJJJJJJJJIJHHHHHFFFFFFEEEEEDDD
@7DJ
TCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTTCATTGATTTGAAGAGTCATTTCTTCTGACTTTGAATTTACAAGAGACTGCTGTAAATN
+
@C@DDFFDHF?BFHGGIGIGIGGGFBHGFGGEHIGHGEGIIBGGBFDFGIHGGHGGIEIIIIGGHEGGGHGHGIIIIIIIIFIIIHEEHE@DFDFFCEDA#
@7DK
GTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTG
+
CCCFFFFFHHHHGIJIJJJJJIJJJFIGHIIEIIIJJJJJJJIHJJJIIJIJJHGHFFDCEEEDCBDDDDDDDDDDDDDDDDDCCDDBBDDDBDDDDDD
@7DL
GCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCN
+
CCCFFFFFHHDHHIJJJJJJJJJHJIGJIFHIIIIIJJJJJJJGIJJJJJHIJJJIJIJJIJJJJHHHGFFFDCDDDCDDD@CDDDCCDDDDDDCDDCDD#
@7DM
CCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGN
+
CCCFFFFFGGHHHJJJJJJJJJJJJIJJJJJJJJJJIJIIJIJJJJJJJHIIJJJHHHEHGFFFFFDEDD;CCDDDDDDCDDDDDDDDDDDDDDDDEDDD#
@7DN
CTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGGGGCCTGGGAGGTGGCGACTGTAGCAGTGGTGGTATCN
+
=?;=:D:D2A<<CAAG?:<3A:<2AH99?)C8::DF*0*0:9?FGIII9FF<?88B8).@;FE(;8/',;55((8(<8(3005>:B:(+++4((28)4+(#
@7DO
ACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
@CCFDEFFHHHHHJIIJJJJJJJJJJIJJJJJJIIIIIIJJIHIJIJHIIIJJJIIIIJIIJHHHHHFFFFFEEDECDDDDCCBBDBDD@CCDCACCCD
@7DP
CGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAG
+
@?@D?DBDHHBHBD@?EHECBBFHAH=@@?DHIIEHI8?B9F;BBCHII;FCAFD===C;=CHB9BACCE=39@=2>9@A8?CC@89?AC88CBBC
@7DQ
AGAAGTTCAAGAATTACAACTTAAAACAGAATTGTTAGAAAAACAGATGAAGGAAAAAGAGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAG
+
@BCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJIJJJJJJGJJJJJJJJJJJJJJJIJJJJJJJJJJIJJIHHHHHFFFFFFEEEDEDDDDDDDD
@7DR
CTTGACGTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTN
+
CCCFFFFFHHHHHJJJJJJJJJJGJIJJJJJJJJJJJJJJJIJJJJJIIIJJJHHFFFFEEEECEEDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@7DS
CTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTN
+
?@@DADDDFBFH?CAEA<3CAA??FCF?F<F?;00??F:';4==?B@2(;65933?C3,''8<8+:+4442(+34:4@C:::>>3@4@(:4?3(+(+<2(#
@7DT
CTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAG
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIEHHHHHHFFFFFEEEEEEDDDDDDDDDDDD
@7DU
ATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTN
+
CCCFFFFFHHHHHJJJJJJIIJJJJJJIIIJJJJIJIJJIJIGIIGHIJJHJJJIEHIIJJJJJJIIIHFHGHHHFFFFFFFEDDDDDBDDDCDDDDDDC#
@7DV
CCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCN
+
CCCFFFFFHHHHHJJJJJJJJIIJJJHGIJJJJJJJJJJIIIJIJIJIJDHIGGIJJJJIIIJJIJGHGHHHFFFEEEEEEEDDCCDD=BBDDCCDDACD#
@7DW
CTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATN
+
@@@ADBDBFB?@@GIGGHG@EG1:CGEG?GGGI?DDHHBHIHGCD:8(=CDAG=BDECCCCCCB;?CCCCCC>ABBB@@>>CD@CCB?2<99909>BCCC#
@7DX
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
@@CFFDDDHFFHFIIJGIIIEFHGGGGHIIJJGIJHHIJJJIGFGIIFIIJJJIJJJICHGIIII7@EHGFE?EFGFFFFFFFDEECCBDDDBD@DDD<@#
@7DY
ATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIHIJJJJJJHHHHHFFFFFFEEEEEEDDDDACDED#
@7DZ
GTCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
CCCFFDDFFFHGGGJIJFIIEIGIGIJJIJJJGHIJGIIJJIIIDCEDGGGFGEDFF=CFIIIJ@ADFDDEEEEDCCBBABDDBDDDDDDBCD?CCCCDD#
@7E0
CGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACTGAGAGAATGCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAG
+
@?@DDDDDHFHH<AFEGGGGGECF:FD>DDHDEBHIBDHEHG@FHIGGHIGGGAG@6@GHHHEE>;>@CCAB;=@BBBBB??:@CBCBBCB?C@BC
@7E1
GTCCTGGGCGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGCN
+
???D?D?::@CDD22<AA+CFCF?EDE?CCCDDC>D@DDEIDDDE<<68BC;7=ACA@A=C26=CCAD;A>;A>A@AA(5>>ADA>>A>82'8<>::33<#
@7E2
CTTACCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACTGN
+
CCCFFFFFGHHHHJJJJIJIJJJJJJJJJJJIHJJJJJJJIIJJJIJJJJJJIJJJJJJJJIJJJIIJHHHHHHHFFFFFEDDDEDDDDCCDDEEDDDDD#
@7E3
GGTCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATGAACTCTGN
+
?@?DDDDDHGHDFIJIJAGHIJJIEGEFFHGGIJEEGHGGGICHIIIJIG4@FHGGGJJIHDHHDFFDEDEEEEDDB/9>5>A@CCCBBDBBCCA>CC@A#
@7E4
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
@@CFFFFFDFDFHIGIIIIFCFDGHIIIIGIEHDDDAGEGIEGHGCHHIIDGGHGH>CBCCCCCABBCBCBBCCBCBBBB@CCC>AB?CCCCCCCDCCC
@7E5
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHGGHHJJJHGIIJJIJIJJJJFEGHJJJJJJJJJJIJJJJJJIJGHIJJJJIGEHGHJJHHHHHFFFF?CCD@CDD,:?DCCCDDDD@?C
@7E6
CCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGAT
+
CCCFFFFFHHHHHJJJGIJGIJJGJJHGIJJJEIJJIJJJIIHIJJJJJIIIIJIGGHIIJJJIGIJHHHHHFFFDEEDCCDDDDDDDDDCDDDDDDBD
@7E7
GTCCGTAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
@@CFFDFFHHHHHJJJHIIJIJGHIGHEFHHGJIJJIIJIJHIHHGIJJJJIGHIJJJJIIIIIIJHHHFFFCDCECEDDDDDCCDD9>AB>CDD2?@B
@7E8
GGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTN
+
<@@DD;ABFC?FFBECFHECFDEHHGEECGGHDHIIDDFHEGIGIIGEAEFEHGHHAFHE<CGFF=7@FEH;>AE<?ECCECCB:BB>C5BADCCDD>:4#
@7E9
GTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGN
+
B@@FFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJIJJIJJJIGJIIJJHHHHFFFFFFEEEEEEDDDDDDDDBDDDEDDDDDDDDDDDD<BDDDD#
@7EA
GGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGN
+
@@@DDDDDFDFHFIACB<FGHIIBHIFGHHIIBFHBFF>FEHIGCFBFFEHIIGGIIIF/=A@@>ACCACC@@C<AC:@CA>>CCC=CCABB3:>>>ACC#
@7EB
CAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGN
+
@@@BDFDFFBFHHGAHIGGIIJIIFCHGHIIIJIJ1C<FEHJIIGGHIFDHIIHIBG@FDHHIIIHFHEEFFFDB;>CCEEEDDDACCCC@38BBCCDDB#
@7EC
GGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTCAGGGTCCTTGGGCCTCAC
+
@@@DDDDDHHBHBEHI>FG=DHE?DFHGDA@@?CFBCGD;A@EEHHEHEC7;;B7?CAAAC?;A?BB<5<@BBB?<9<B>A>A?9AAC>39222+2:A
@7ED
CCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCN
+
CCCFFFFFHGHHHJJJJIIIIHHIJJJJJJJJJIIJIJJJJJJJJJJJJIGGIJIGJJGJGHHEFFEF>CCEDEDDECCDDDDDACDCDCCACDDACD?B#
@7EE
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
@@CDFFDFHHHHGIIGJGHHIJJGJCEHGCHIIGIJJIJGGHGIJJIJGHIJJJIHBGHGIGIIEGGGIII=AEBBEDDEEECCCCEEDD@CCCBDDDDC#
@7EF
GGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTN
+
BB@DDDDDHHHHHIEHIIJIIIJJJIIJJFGGJJJJIJJIJIJJIIJHJJJIIJIJIIJJIHHHHFHHFFFFFFCEEEEDEDEDDDDDCDDDBDDDCCBB#
@7EG
CTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIIJJJIJJJJIJJJJFGHIIJJJIJJJJJJJJJJJIJJHHHHHEHFFFFF
@7EH
GGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTN
+
CCCFFFFFGHHHHIIJJJIIHIJJIJJJJJJJGIJJJJJJIJHIGJJJJJIJJJJJJJIHIGHIGCHGHGHHHHHDEFFFFEEEDDDDDBDCDDDDDDDD#
@7EI
GTCCTTAAGTGCTTTTAGCTCCTCAATCAATGTCTTGTTTTGATTTTCAAGCACTGCCACTCTGTTTTCTAAACATTTCACATATTCTTTCTTCTTTCT
+
CCCFFFFFHFHHHJJJJJJJJJJIJJJJJIIJIIJJJIJJJJJJJJIIIJJJIJJJJJJJIJJJHIIIIJJJJJIIJJHIGGFEHGFFFFFFFDEDDDE
@7EJ
CGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCCGTTGGTCCCCTCCCAGGTGATN
+
?<1AADD>C<<<CE;@BFDFFDFHEFAFGIFCFFFIFI@FFFI@;DA?CE;BBDBCCCB8?@BBBBBBDDBBB@@@BB9&08<8?ABBB?BBBBBB+:>B#
@7EK
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@;?DDDDDHHHD?FGGG@H:?EEE<8?EBD>B??<?::?9:BFB?DFHGIADC=CHGEG;=(7@==@>AECA.;@;?BCAB>38;B8@?C@+>43812<9#
@7EL
GAAAAGCCTAAATAAAAAGCTTCAGTTTTGACCTTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTN
+
CCCFFFFFHHHHHJJJJJIIJIHJJIIIJJJJJJJJJJJJJJJJJJJJIJJJJJJIJJJJIJJGJIJJJJJJJJJIIJHHHHHHHFFFFFDDEEFFFEED#
@7EM
GTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGN
+
@@@FDDDDHHFFHIAGF<DIEFFHGIEGHFHIIGGIIGGDGGIHIFEIEHIIHD=FDFFDHCD@FHHHIDGIHGHHD?EEFFC?;BCEAC6?CCCCCCCC#
@7EN
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
BCBFFFFFHHHHHJGIJHHIGHIIJJJJJJJJJJJGIIJJJJJJJJJJJJJJJJJJIIIJJIJIJJJJHHHFDDDDDDDDDDDCCDDCDEEDDDDACDD
@7EO
CCGCGTCCTCCTCCTCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCN
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGEHFFFFFFDCDEDDDDDDBCDDEDABD@DCCCDCC>CCDDDB@@A:C#
@7EP
CAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTN
+
@?@FDDDFBDHBFBGFGGGIGGICB@B?CCCCC8>A8>>CDCCA?8@CB?BB@BBAC@@CCCCCCC>:C@AAA@A@BB5<>C>ABC??@C34<<@C(:?:#
@7EQ
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
CCCFFFFDHHHHHJJJJJJJJJJJJJJJJHJJJJJJHIHIIIIJIJJJJJJJJBFHIGIJJ5@DHEHHHEFF?ACEECCDDDDDDDDDDDDDDD<BDDDD#
@7ER
CCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCN
+
CCCFFDFFHHHHHJJJJJJJHIJHIIJJJJJHHIJJJJJJJJJJJJJIJJJIJIHHIJJHIJEHHHGFFFFEEEEEEDDDDDDDDDBDDDDDDDDDDEED#
@7ES
GGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGCGGGTA
+
=1:A+@D@A2<+CEBE@8?E?EECD@<D<DA@D?88DD<DB===BBAAAE;6==CAC=C>=7.7??>;@;;(((5(,---,,555:A:;:=?>&)0;&)
@7ET
GTTGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFFHHHHIIJJIJGGJJJIIIJIIJJJIJJGIIJIGHIJEGIIEHIJJIFGIIIIIIJIIIJIJHHHGFFFFFFDD3;@B?CDDDDD:@AB?BD#
@7EU
GGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGGGCTGTGCGGGATAGGGGTTTTCCGGTTGGN
+
?<@D?DFDDHDHHHIAGGHIIIIIB4=CEHHFFFFFFCBBBCCCCCCCBCCCCCCCCCCC;?<BB@BBCCC?@CB<CCBCC@BCCCCCCCCCCC8@BBBB#
@7EV
CCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCN
+
CCCFFFFFHHHHGJJHIIGIIJJJJJJJJFGHIJIJIIIJJIJJJJJJJIJJJIGHHIJAGHGHEHHHFFFFDFDDCDDDDDBDBDDDDDDDDDEDDDDD#
@7EW
CGGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTN
+
@@@D;A22@DFFDFIIF>H?EEFFG<;CGA93?8BFIICEB=9;BF9)B<FEFA;1;E=6=7=;?@BD7?;@AA@CEBBABB;>??BB@ABA(>A@AABD#
@7EX
TTTGGAAGCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCN
+
BC@FFFFFHHHHHJJJIIJJJHIJJIJJJJJIIIJIIJFIIGIFHIJJJIJJJJJJJJJJGIJIJJJJJJJJJJIJHHHHHGFFFFDFCCEECDDDA>AC#
@7EY
AGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGN
+
@BCFDDDFHHHHHJJFHIJJIJJJJJJJJJJJJJJJJHIJJJJJJJJJHHJJJJJJJJJJHHHHHHHFFFFFFFEEEEEEEDDEEDDDDDDDDDDDDDDD#
@7EZ
GGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTN
+
@@<DDFFFHHHHHGGIGIIGHJIHJJJIJJJIJIGGGIIJJFGG?DDEGGIJIIIJIIGGIIIIIJJFGHHGHHFHFFFFFCAEEEEAC=AABDDDDDDD#
@7F0
ATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTN
+
???ABDDDC+CDBEEEEEFDEED+::+<@CCBDEEFIDIIIDD)?DD>DDCC8)=;@@DADDDDD:?CD?DDAAA@AAAA>>;???ADA3>A??><<?<(#
@7F1
GTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTN
+
@C<DFFFFHH4<F@EFDHGIIBHIEEFFFFCB<@DGC@G>BDDDFDFHIIH?FDFHEGIEFG>FHFHGEC=;;A55==AACEEA?BCCCCCC>A:;95<A#
@7F2
TTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAA
+
@@CFFDDDHHGHHJJIGJIJJICHIIBHHJJFGIJIJIJJJJJGGDHIGIJGIJIJIIGGJJJ=HGEIHIJHHHHFFFF;@BEE>CA;AACCDAFDDDC
@7F3
CTTCCTCTTCCACAAGTGGACCATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAA
+
@@@FDEDADFBB?AEH?EFCB@FHIEHEHIFHBEGHBB@F:AHGGHGDHGICD@DA@E:BBB;;@=(9ACC@@@BB@AD39>A@?CCC>A>CCCCCCCC
@7F4
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@@?D=A@DHDHHGG@CE<CCEDHDG<FHD?CEHIICEDEGBFGEDGGEHIH8BFG6;;.===ECDHEE@AE:BEE7>>A;A@B;ABBAC>?:?<+8@
@7F5
CCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGC
+
@@@DDFDDHDHDABB?EEHHIIIGHA@FFBB<CFE@=CD<GAHDBDGEEHDHEHGHHIIIIFGGIIIIHD8>=CCD@@ACDCFCC@CCBDDCCD>BB@
@7F6
CGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTN
+
?@?DBDDB?<FFDEFGD<C<CF@FH@??FA???FFGGBH1?BG0?BBFHGEBBGABGDHI@C@D8BEB<@AAC>?@BCE::??2@@C59@@???>8><C@#
@7F7
TTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGT
+
@@@FFFFFFDHBDBDDDFFBHIBEEHDHEFHEEIIEGE?CFCFGCDFHGIBF?DH@DH=@DFHDAF-;ACHC?=@?DCBB>BB35<02?BBC05<>B<)
@7F8
CCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTN
+
CCCFFFFFHHHHHJJFHHJJJIJJJJJIIHIIJJJIJJJJJJJJIGHHIIJJJJJJIIJIJJIJJJJGHHHHHFFFFFFFEEEEEEDDCDDCDDDDDDDD#
@7F9
AGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGN
+
@@@DADDDBDHBHGG:GDGFH<BE?FFDHIIIIIGII>?BFDHIIGIIDHEG=FCHIIIHI;=C>EEEEDDDDCCCCC?ACC=;ABBBB<CCCCDA@<@B#
@7FA
CTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCN
+
@@@DDDDDFFHHDGCFHIIIJGIEHIGFDGHGHGG?DFFHE:@GDFHDD@BDH@GEEHG=DH=DEAACEFDFFFFEE@C?CACCDACDCCBB@??BCBB?#
@7FB
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTN
+
@@@FDDDDHFHFAABGFGHHDEBG>F=FGGHGFHIGIIIIG>CFHHIEHHIIIHFFAEC@DDD>A>>@CCC;ACCBCCA;@CA@?@8>9?ACC?AA@44:#
@7FC
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
@@CFFFDD>?FHHFHAFHIIEBFHHEBAH@FHIGGGCCGGGGGEBBDHGG0<@FE83=>BCCCB<ABBBBB@CC00<9>A@CD:@CA3>9:@@>@DCCC
@7FD
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
@@@<DDBDHHAAHGGEBD>BHFGEHEHGIIII?FGGIGIIIIICHEGG?HGIGFHHHBDFEF@CCACCDDC>CBDCCDDDDDCECDDDDCCCDCDD@CCC#
@7FE
CATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATGTTGAACAGATTCCTCCATCATCATAATGGCTTGGATN
+
CCCFFFFFHHHHHIJJJJJJJJIIJJJJIJIJJJJJIIIIJJJFFGIIJJJIIIJJJIJIGGJIJJIIJIJJJJHHHHHGDFFFFFEDEECEEDDDDDA@#
@7FF
ATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCN
+
@BCFFFFFHGHHHIIJJJJJIJJIJJHHHGIGIIGIJJJJJJJJJJIIIJJDGHGHIIJIJJJGJHHHHHFFFFFFEEEEEEDDEDCDCBBDDDBCCCDC#
@7FG
TGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATN
+
CCCFFFFFHHHHFIJHJIJJJJJJJJJJJJJJJJHIJJJJIJIJJIIJJJJIJJIJHIHIJJJJJJJJFHHEEFFFFFEEEEEEECDDDDDDDDDDDDED#
@7FH
GGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTN
+
@@@DDDDDBDH8AAEAEAFIGHIIGGCHIIIII9CFHGHGHIGIEFIIG@F9DFBFEEHI=B=DEDEDCCCCABBABBB@<CCCCA@@<CCC@:<@ACBA#
@7FI
AGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJHIJJJJJJIJIJIIJJJJJGJJJJJJJIJJIJJJJHAHFDDD>CDDDDCFDDDDCCD:?B;CCDEED
@7FJ
CCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAA
+
C@@FFFFFHHHHHJJJIIJJJJJJJJJIJJGIJJJJJJIIJIJJJJJJIJJIIIJIIJJJIJJJJIIJIIJJJJJJJJHHGHFFFFFFECEEEDDDDDD
@7FK
GTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGN
+
B@BFFFFFHHHHHJJJHIJJJJJJJHJJJJIIGIJIJHJIJJHIIGGIIGJJGIHIJIIHGIJIHIGGGGGIGGECDHGIHEFHHEFBDFFDEEEEEDAC#
@7FL
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGN
+
@@CFFFFFHHHGFJGJJGIJIJIJGJJJIIIJJJIGJJJJIGHGIJIGGIJJGHIJIGIJIJGADCCEHDDFFFFEDEEEEDBDDBDDDCDDD:@CDCCD#
@7FM
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
CCCFFFDDHHHHHJIJJJJJIIJJJJJJJJJJJJJJHIJIJJJJJJJJJIJJJJJJJJJJJJJJJJHHIHHHGEHFFFFFFFEEEEEEDDDDDDDDDDD@#
@7FN
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGA
+
BBBFDEFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJDDBDDDDDCDCDDEEEEEDDDDDDDDADDDDDDDDDEDDDD
@7FO
CCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGAT
+
C@@FFFFFGGHHGIIIIIJFHIJJJJJHIJGJJIHHGGIJJHIIJIJJJJGIJJIHEHJJFHIG=DHHHAEEFFFDCEECDDDDDDBDDCCCDCCDBB:
@7FP
CGGCAGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFADFHHHHJGHIJJJJJJHJJJHIJJ?FHIHIIJIIJBFHIGCEGIJIJIIIIIIIHHGDEFFDEEDEDDCDDDDDDDDDDDDDDDDEDEEEDDC#
@7FQ
CTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTN
+
?;?=BDD;CA:A?:EGIIIBHFHGGCFEG<CFHIICH@HGCIGIIDGGGIGEG=F0?A-=@F@A@E>CHIIFHHEH?@=?=>ACBBBB&0<CDCCC?CC>#
@7FR
ATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJIIJJIJJJJJJJHIGEHHHHFFFFFEEEEDDDD=CDEEDDDDDDDDDDDDDDDDDDDD
@7FS
CTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCN
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJGIJJJJGIJJJJJIIIJJIIJJIHHHHHHFFFFFFFEEEEEEDDDDDDCCDD#
@7FT
CCCAGGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAA
+
8=@=BDDDAFF?F<E2<:<EHFCHFF@CFHHFBFEFFEB?4?F@D??FA@FBBDFADFF=CD;=F>C;==7.=@@EEF>?D>8=<>5=(;-->:?BBBB
@7FU
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAGATCAGTGGGCTGTCCATAGGGTCCATAGCTTTGTTGN
+
=<?DBA<D;,2ADB<BCD@D?8::C?<B<?>DC*9B;3B*930?=BADB7=@CD;;).==.)7?@));3.);>(;>(-(5;>>A(,(,,5>:(4>:>4(+#
@7FV
CAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACN
+
@;?BDDEBFD8CFGGHIGFGBFBHICHIIG;ECBDE:BF8BD1DFD=F@=BF8C=<A=BD1>>CCBC?;3;8???CCCCC@5?ACBB@CC>C>C>:1:8<#
@7FW
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
@@@BAAD:===DFIBGG:8:<<AAA??GG??C?GGBGB?F90??FD?F899D4B=<FCAFA=./.5A<A:6)..7A>A;>;A55@@=,5:8:?=;(+28
@7FX
CCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTN
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHJJJJJHHHHHFFFFFFFEEEEEEDDDDDDDDDDDDDD#
@7FY
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFDFFFGHDFGIAHIIGGGGFGHGGIHGGIIBFG?GEGEIEGDHIGGHHJIGCGGAFFIBGGEHHHHHHFCEDEFFBDB>=BD;ACCDAC:CDDBDD#
@7FZ
TCCAGTTGTGCCCGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCTA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIIIJGIHHHHHFFFFFFFEEEEEEEDDDDDDDDDDD
@7G0
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@@@DFDADFFHGDGDHHCHHFDFHEEADDEIGHGGGGIIIDHHGIIHFGGGIIIIIIGCHCAEFBD=?B9@ACCCCBB@B@CCCCCA@4@>CCBBBBBBB#
@7G1
TGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCN
+
CCCFFFFFGHHHHIIIJJJIIGIHJIJJJJHHIEGIIIJGIIGJJFHHIIJGIJJJJIGIHIJII=FHIIIJJJHHHHHHFFFFFFEEEECACCDEEDED#
@7G2
ACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTN
+
?=?DDDDB?AFAFG9FF@A@E?CFEGGIGEHIDBDGCCEE<BDEI@@;FG;7C@EE>C=7@372;>@CCDDE;>CCCCCCCBCCBCCB9>CC4499A>::#
@7G3
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
@@@D?>DBFHAF>GGEHGEHG<EAFGC;CCEEG<<FFHB@DDDHDF:BDGGEE06;B-==?C>E7?BEDC>AB@BC;>??@?CCACCCCCAACC?@>A3@#
@7G4
CTCGGTTCTTCGTTTCCATTAAAGCAACTGGCATAATGTCATCTGAATTCAAACAAATCACATCGCCATCTTCACCTTCAAAGCTTTCATTTATG
+
@@@DDDDBFHB?AEEHIGDEDDEH@CEGBDFGGAGEGGFHIGEGIIECHICAHCGGDDBDGCHICC@;CGGEAAEHEEECC@?>@CCCCCDDCCC
@7G5
CCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJHIJJIJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIHHHHHHFFFFFACEEEEEEEDDD?@DDD#
@7G6
GACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACA
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJIJHIJJJJJJJJJJJJJJJJJIHHHHFFFFFFFEEEEEEDCDDDDD
@7G7
GCCAGATACTGCATCCCCTGTGAGATCTGCCAGGCAAATGAGATGAGGTCGCCCATGGTGAGGGCCCGCTCATCCGGGTGGTCCAGGGAGCTGGAGTTGCN
+
1;?BDBABFD?:?CF>CDDDA?CHEH@@9F3C9CC;CG<1?BAB99*??FFB=EBFFF=@FFEEE=<B@<;3>BBB?B',90+:@><9<@0<ABBB>(>A#
@7G8
CCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATN
+
CCCFFDDDHH?CFFHFHEEHGGFIIIIIIEEHD?EFD?GDHGHGHIHCFDGIGGGIHIDHIIAHHIIIIIIIIIIIIHIIGGICGHHHFCCEHE@BEDFD#
@7G9
CCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTN
+
CCCFFFFFHGHHGJJJJJJJJJIJJIJJIJJJJIIJIGHHIJJGIHGGHJJJJJJJJJJFGFHIJIGIJJJIGHHHHHHFFFFFFDEDEDDDDDDDDCDD#
@7GA
GTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCN
+
CBBFFFFFHHHHHJJJHIIJHHHIIJIJJHIJJJJJJI:BFHIJJJJJJBFHIIJJJHHHFFFFDDDDDDDDDDDDDDDDDDDDDDEEDEDDDDDDDDDD#
@7GB
CTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCN
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJGHIJJJJJJJJIJJIJJJJIJJJJJJGIJIJJHHGHHFFDDDDDDDDDDDDDDDDD#
@7GC
GCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTG
+
CCCFFFDDHHHHHIIIJIGGIJIEHEEHGEGIIJIJIHJIIIIIIJIIIIIIIEGIB@FHEHGGFFDE@CECCDBDBDDCDCBDDDCDDDDDDDDCCCD
@7GD
CTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCN
+
BC@FDFFFHHHHHIJIJJJJJJJIJJJJJIIHJGIIIJJJJJIJJJJJIJIJGIIIJGIJIIIHHHHFFFFFECEEEEEDDDDDDDDDCDDDDDCCD>CA#
@7GE
CTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTN
+
?@@FFFFFHHHGHGGEIGHGEGGGIIIJJJJIFHEGHGIIAHEFFGGGJFGIHHIEIIIHJ8@FGEHIIJHFEHFFFFFDDDCA;CACC@CBDCCCDCD;#
@7GF
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
@@@DFFEDFB<?D@FCFGCGHG?CHIHHIGABEHGHG?FGGGIIGFGHHG>DHHIIIGIGGH@G>8CGHIEDG@C3AEA>BD7=B3;CC@CCC;@CC>>C#
@7GG
CTGCTCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
@@@<D>DDBDDBFG?@C:<33CHH?98FEDF?0:D<FFC>((-==8C4=7@F)@7=;A:8BEDCC@@:;5-5((55(5>@;(;@>AC>CC49(8@3<>>8#
@7GH
CGCTGCTCGGTTGCCCATTGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGN
+
=?1::)AAD<<1C@E:2A?EAF8??1?9?>>??BD*?D4<D3DAA88B9DCC@BADI=A/'-;<=?A:@37?AA@(..;;?;>A?5>'85>>?:(:8A80#
@7GI
CGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGN
+
CCCFFFFFHHHHHJIJIJJJJJJJJJJJJJGHIIJJJJJJJJJJIIIIJJJJJJHFDDDDDDDDDDDDDDDDDD<BDBCCBDDDDD@CDCDCDDDDDDDD#
@7GJ
GCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGAACAGGTACCTCCTTCATATTGGCAGTCAGCGAAGAGGGCTCTAGGAGCAGTGAGGCCCCN
+
@@@FBDFFHHHHFIJJIIIGGIIEEFEEEGGGIHHGDFGIDEFGFAGAGGFDHGGJGGCAHEIHJJCCHHFDFF<A?BDD?BDDDDCC@A?AAC><@DDD#
@7GK
CCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTN
+
@C<DFFFFGGGHFHG>GGHIJIIIJIEGGFCHHIIGBGFEGIGFAGIJJIAGHIG?;@FHHGHGEHEAEHHGHFFFFBDEC@>CECAC?ACCDDCDCDCD#
@7GL
CTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTN
+
CCCFFFFFHHHHHJJIIJIJJJJJIJJJJJJJJJJJJJJJIJJJHHHFFFFDDEEEACDDDDDDDDEEEDDDDDDDCDDBDDACDDDDCDDDDDDDDDDD#
@7GM
AGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGCGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGN
+
+1??BDDBAF7DFBEFEE?<<AFD3?HFEHF;F;DG;F3??0:0?0**088(--';@@4;E(5::?B:77@B>AA;>A>@B>>@>@:(5,,:@BDA<35?#
@7GN
CCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCA
+
@@@;D;DDDFDDBA?FBCHIGBIIEGAD<?E?B4CFHI<E<99?CGHH>4?FGGIFHGEBD:9?DFBFICEG8=BCGGIEHGGECHGIE@A>CEHA@@@
@7GO
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJIJJJJJHHIJJJJJJJJJJJJJJJJJIJJJJJHHHHFFFFDD;AB;@D?BDDDDCFDDDD@CD:?#
@7GP
GTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCN
+
CCCFFFFFHHHHHJIIJJJJJJJJJJJJJIIJJJJJJJJFHIGIJIIJJJJJJJJJJJIJHIIJIJJJJHHD>BBDEDDDDDCDEDDDDDDDDDDDDDDD#
@7GQ
CGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGT
+
@C@DDFDFGGDHHJGGHIJHIJJJJIDIJIIIIEHGIGGDGHGGIGD@FHGIJJJIHHGEFFDDDDDDDDDDCCDCDDDECDDD9<?CDDDDDEDDDDA
@7GR
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
CCCFFFFFHHHCFHJIIJJJJJJJJJGIJJJJJJJJJJJJJHIJJJJJJIJJJJIJJJJJIJJJIIJJJJJGHHDEFFFEEEEEEEEEDDDDCDDDDDDD#
@7GS
AGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATN
+
@@BFFFFFHGHHHJJJJJJJJJJJJJJJJJJJJJHGHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIHHHFFFFFFEEEEEDDDDDDDDDDDD#
@7GT
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGGACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
???>B<BBDDD<DEI22AE<CFECFEDCE>D@DDBDCBDIEADDBDCDDABEEDDC'-;CDCDDAAD'5=@@????72<>AAA>>AAAAAA>AA:AA>4
@7GU
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCN
+
@@@DDDFFD?FDDHIGGBGECHGGGIJIJGEFHGGGG?DDDACHGHGI@FDGIIEHAADCDBBAEECCCDDDDDDDCDDDDDDDD>A@CCCCCAC@CDCC#
@7GV
CAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGN
+
?@@D:=DD?CD<ACAEGH@DHFDCFFHD?F@G4D@HIIFGIIDII6ABH@E;D@)76AEHEE7@>6@66.3(5;@ACBACC9@C:55@CCB?8222<+2<#
@7GW
CTGAGATCTGGAGACAGGTATCCACGACCCACCATAAAAATTATCTGGACCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATAC
+
????DDDB?:22<;CE?C<A:AA,3A)))))1?)*??>D9?D8*?***)..(...8=;A2@A)?.=C3)7;AAA.6(>@6@;;(;>>;>>A>>;(:A>A
@7GX
CTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTN
+
CCCFFFFDFHHFFGIJHHIIJJJJJJJJJJIIJJJIJJJJJJJIIJGIIGEHIHIIHHJJDEGIGDHGJJJIIGGHGJJGHHHHHHHFFFFFFFEEEEEE#
@7GY
GGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCN
+
CCCFFFFFHHHHHJEHIJJJJJJJJJJJJIIIJJJJJJJJJJJJHHJJJJJJJJJJJJJJJJJJJJJJJJJJJH?EFEFEEEEDEEDDDEEDDDD@CDDD#
@7GZ
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCC
+
@@@DAD@@DDDF><ACFHEE?A9CH9?FC??EGCHCD4CF3B?BFFHHIDHABDBHEIIGICHIG@DHG@5;=?3=>>A;;598?C@@>:C>ACC@C@@
@7H0
CTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCN
+
CCCFFFFFGFHHHJJIGIIJJDHHJJIIGJJGIIJIIJHGJJJIJJIJJJJJJJIIIIIIIGGHIEGIJJJJJHHHHHFFFFDFDABDDDDDDDCBDDDD#
@7H1
GCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTN
+
CCCFFFFFHHHHGGGJJFGIJJJJJJJJJJIJJHIIJJJJJJJJJJJJJJJJJJHDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDD>CBA@CDC#
@7H2
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCCFFFFFHGHGHJIJJEGHFHIIJIIIJIJJIJJIJJIJIIJJJJJJJIJHJJJJJJIGHCEHIIJGHHHFDDBDBACDCDD:9ABCDCDDDDDCCDD
@7H3
CCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTT
+
CCCFFFFFHHHHHHHIGIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJGIJJJJHHHHFFFFFFFFEEEEEDDCDDDD
@7H4
AGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCN
+
B@@FFFFFHGHHHJIJJJJJJEFHIJJIGJJIIIJJJGJIJJGHIIJJJJJIIJJJJ8AEBGEEHFFFFEFFECECEC>@B;CDCEEDDCDDDDBDCCCC#
@7H5
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGN
+
@@CDDFFDDFDFHGIIJJ?FBGCFDGHGIIHIIJJHGGIDHBFGI@FHHIDIIIJJCCHGCHEIJJFEHFDFFFFADECCEC@B38?CDC@CC@C@@C:A#
@7H6
GGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTA
+
CCCFFDFFHHHHGIIIIIICHIBGGIIIGIGIIG@FGBFHBCCGHEGI>GE@F>@=EGGGGGF;>?B<?C?>CCCCC;>@ABCC@>ADCBBCCDDCCCD
@7H7
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
BCCDDFFFHHHHHHIJJHIJJJJJJJJJJJJJIJJJJJIJJJIJJGGHJJGIJJJJJIJHHGIIIHFHHGFFFFFFFDCEEEDDCDCDDDDDDDD9>B9@#
@7H8
AAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCN
+
@CCFFFFFHFFHFII@FHIIIJJJIIGHGIGIGIGJJJBHHGGHIDGGICGGHJJGHGGIJIIIJJJIHEHHFFDFFDCDDDDDDDDB@CC@ACDDC?BC#
@7H9
TGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJ@GHFHIEHHIIJJJJJJJJIJJJJJJJJJHHFFFFEEEEEEDDDDDDDDDDDEEEEDDDDDDCCDDDDDDDDB#
@7HA
CCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGN
+
@@@DD80ADFD??CGFIIIIIEECFFB@FDA?@?@FFEE@*?D<B<AAF7=@;C=3=?;=BDB;?@C@3>BBBBB==?B<>(5>AABBB)0-9:@AABA<#
@7HB
CGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGN
+
@<@DDDD6???BFBGIE@6?0:D:@;:7C=..5;5777..?B=75666.6;@BBB@5(99?38;2+4:4944:>B@:444?:A44:@+88>832(.9.90#
@7HC
GGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTT
+
@@CFFFFFHGGHHJIIJICFBHHJJIIJJJJGIIIIJJJJJJGGHFHHHBDFFFFFEEDEECEDDDDDEEDDDDDBBBB?CCCDCD?CDDDDDDDDEDD
@7HD
GGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGTTN
+
BCBFFFFFGHHHHJIJJJJJJJIHIIFHIJJJGHHHHGHIHIJJHHIIJJHFEGIJJJIIJJJJHAHEHF@@CFDEEEE@ACDACCACDDDD?CCDC?AB#
@7HE
ACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJJJJIJJJJJJJHIJJJJJJFHIJIJJJJJJJJIJFIGHHHHFFFFFEEEEEDCDEEEDDDDDDEDD#
@7HF
CACCCCAGCATGACATCGTACACCTCTTTGGGGCATAATAGGGCCCGCTCCAAAACACGACCTTGGGCAATGAACTCAAAGACCTCCGTGGTTGAGAGCTN
+
1:==A@;BB8+:2++,<C+A+<+A3:**11*):?0)9*0**0?3(7''''-)=A2.??'9/''((;9,5<:3(,::5+34+9+(+480<(&2029:((((#
@7HG
CTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGN
+
@@@DDDDDFAFFHAGHIBEH?E<CBFFHIEGHGDGEEHGGIGIDEGGII@AH<?FAHCGH<8BDGHGIIIIIIIHGGHHFEEEEECCED>>@>@CEDCCC#
@7HH
CCAGGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAAGTGCAGTGACTGGCTGN
+
CCCFFFDDHHHHHJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJIIJIJJJJJJJJJJJDHHHHHFF5@BDCDDDDDDDDDDDDDDDDDDDDD#
@7HI
CTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACC
+
CCCDFDFFHGHHGIFJJJGIDHIIIGIEHIGGGIIJJIGIAHIJJIFGIHEGIJJJIJFIIGIGGGHGIFHEEEFDFFFDDDED>CDDCDCB<??BCDD
@7HJ
GTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATTAGTCCT
+
CCCDDDDFHFFHHGFGHGFHGIGJIJEHHHDHGIHGIJIHIJGIIIJIHC?BGHGIJGHGGGDGGIIJIGFGCGHIGIIJGEHHCEHFFFFFFC>@CC
@7HK
CGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTTCCGCTCGCCCCAGCGCCTGGCCACCTCATCGGGGTCCGTCATTTTGAACTCCCN
+
???BB88ABD<?):CE9ED>@DD<?;28B9DDD?BB2AAD=A<>CAC@>D<<?9>=;????=?<7<?<>38<88AA49>>?&089><<8A>DA<AAA>A<#
@7HL
CTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTC
+
@??DDFEFDFFHFFHGGGG@FGHBCHEFHFGHGAAHHIDHIG:?D>;5@FHICIFFHCEHC@;C>CC??@B@BACC:4>@A>CCBB7@8ACC:8<<B0>
@7HM
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
CCBFFFFFHHHHHJHIJHHJGHIJJJIJJJJJJJJHJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJHHHFDDDDDDDDDDDCCDEDEEEDDDDCDDD
@7HN
CTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTN
+
@@@FFFFFHHHFHIIIGIHHJGJIJIIGGIGIGJJGHIFIGHGHJJJIJJIIJIJIHIJEGEIGIGIGIJJJJEGHGIJJGHHHFHEFFFFFEEDEECDE#
@7HO
GGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAA
+
CCCFFFFFFHHHGGHIJIJJJJJJJJGIIIIJIJJIJJIJIIJJJJIIIJJJIIIGJJJIJJJJGHJIIIIJJHHGHCCDFFFDDDDDDDEDDDEDDD
@7HP
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGN
+
@CCFDDFFHHHHHJJJJJJIIJGHJJJJJJJJJJJJIHJJJJJJJJJJJJJJJJJJJJJJJJJHIIJHHGHHFFDDBDDDDDDDDCDDDEEEEDDCD@CD#
@7HQ
TCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCN
+
CCCFFFFFHGHHHIJIJIJJJJJJJJJIJIGIIJJGHIJIJJJGJEHIJJJIJIIJJJJJJIJJIJIIJJJJJJIJHHHHHHHDEFFFECEDEDDDDDFD#
@7HR
CTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGN
+
@@@DDDFFHHHHFIJIJIJJIICHFHGHIIJJEIGIGGGIJJGIJJJGJIEIIIGIJJGICHIJGGIIJJIGIGIJJJICEGHGHHHHHFFFFFECEEEE#
@7HS
CGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACN
+
@@CDDDDEHHGGHJIJHHGHIIIIJIGGIGIIJIJFGGGIGIIIIIGIJIJEGGHIIIEGGGIGGGGIGIJFIGCHC>EEEBDEFFFBEDEDDDD@CDDD#
@7HT
GCCGCCTTAAATCACCAAGGTCTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATN
+
@@@FDFAAHHFFAFHDGG9F+2AF>CB?BA>FGHGCHGBFGIHIE9DBDGGIIICFH@H48BFHIIGIEEHGI)@7@@EHHE>B@@CC>CED(6/,;;=?#
@7HU
CAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTN
+
CCCFFFFFHHHFHIJIJJJJHIJIJJIJJJJJJJJJJJGHJJJJJJJJJJJJJJJHJJJJIJJJJJJJIIJIIHHIJGIJIJJJHHHHHEHFFFFDFEEE#
@7HV
AAAGCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCN
+
@?<DDD?DDDBDFE@AEHGEIAHHGHG@HG@?;AAHHD@GGFEEHEBDCCCAAB?B@BBCBB;<>CCCCDC@>CCCCDCCCCBBCCCCCCBB<<<<A?B@#
@7HW
CGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
@?@DDDDFHHHHHIIFGFICGHDHIIJGGIJFDDEGBGDEHEIJGIGIIGGGEIJJGIJGHHHFDEECCCCEDBBDBB5:ACCDDDDDEDCDDCDDDDCD#
@7HX
CTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGN
+
C@CFFDFFHGFHHIIJJJJIIJGEGFGDGIJ@FGHIIIJBHIIAHCGGJJJJJJJJHGGHFBDDCEECCDCCDDDDCCDCDDCDDDDCDDCCC@CCB@CD#
@7HY
ATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTN
+
?@@DDDDBHDDBDGIDFE@BA??@BB<F+A?<?FHICGDE>DBCEFGEEIGHGBD@???DHA@D>FFCHAFIAHIEHGICG7=@AEA?ECCHEEE>;BCD#
@7HZ
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
???DD?ADFB?HDF<+<?CDFG@=@EG@<@GFCDFAB@GFGBCBHGIGGGB>FHIC?BEHH?EE@B>;@B;B3>(;CC5;>A;(5>C::((;??3<?B9@#
@7I0
CTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJFHIJIJIJIJJJIJJJJJJJJJJIJJJJJJHIJJJJGIJHHHHHFEFFFFEEEEEDCCDDEDDDDDDDD
@7I1
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
????D::B+1CDD6<A<EB>EFC@F<4?D9:C@9:C:D1:???4?DDIDDDD:.88BD3'5;)(=?7=).;;A@@=3(.6>A:;>>3>;>3>AAAA:,,
@7I2
GCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGGAACCTCTATTN
+
C@CFFFFBDHHHFIIIFHGGCGEGGFHHGEGHGGGIIIGEHGGIIIGGDFFHGEGICGCBFFHDHIGIIHIIJC@=?EA?;?DB>DDDDCACCBDCDCCD#
@7I3
CTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGN
+
CCCFFFFFHHHHHJEGIIJJGHGJJIIJIIJJJJJHHHHFFDDEDEEDDDDDDDDDDDDEDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCC#
@7I4
CTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTN
+
<@@DDDDDAC<?<A<:A@BHHGIIBEFC@FD<GHIE9CDDHC>FA?GDH>GHIGBHGEH<?B).8BCHGI>A@;DHG;37=CC>A?C3;7?3@;;6>A;@#
@7I5
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@CBDFFFFHHHHHJHIJFHIGHIJJJIJJJIJJJIHIIJIJJJJJJIJJJJJJJJJJJJJJHIJJJJJHHHFDDDDDDDDDDDCCDCDDEEDDDDCDDD
@7I6
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIIJJJJJJIJJJJJJJJJJJJJJJJIJGGIIJJJGIJJIGGEEHGEEF@DDEDFEDEEEEC@CCCACD?BDC#
@7I7
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
CCCFFFFFHHHHHIJJJJJJJIJJIJJIJJJJJJJJJJJJJFHIJJJIIJIJIJJJJJJJGJJJJJJHHHHFFFFDD;AB>BD=BDDDDCEDDDD>CD:?#
@7I8
CCAGGTAGCCAGGCCCCACTTTGCGGCTCTCGCGGAGGAAGCCCCGCAGGGAGCCGTATTTGGCGTACTCCACGATGAGGAGGAGCGGGCCATCCTGGCTN
+
@@CFDEDDBHHHDHGHHGIGHIJGIIGGHGIJJIJGGIHFHGFFFDDDDDBDDDBB<BDDDEDDDBBDBDDDDDDBDCCDABDDBDDDB<>BDDDDDCB?#
@7I9
GTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCN
+
@@@FFDDFGHGHHGGIJJIIGEFHIIGIIIIGIIGGIHIIJGEIJIFHEGGGD>GDAEEEHFE>DFD>>CEEDDDDDDDDDC;@CDDDDACCDDCCC:@C#
@7IA
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
CCCFFADFHGHHHIJIJBHJIHGEGGIHGIGIJJGHGGHIEHIHIGIGHIIIIJJJIJJIJIJJJ@F@ADC97?EECDEFFFFDEE@CDDDDDDDDD>5<#
@7IB
CTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATN
+
@@@DDDDDAHHHHDIGIIGB@<FFEGHIEEGDBGIIIGGIIIIIDIGEGBDDDGIC@FE=88B@GIIDG@A=A=D@GCHEFECEEBDCCCCCCCCCCCCC#
@7IC
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@CFFFFFHFHHHJIGIGIIIJGEG2CGIIJJIFGGIDGGGIJJDHGIIIGHGIIHHDFFFFECECEC@ACDDDDC@CDDCCCCCDDCDDDDDDDDDD
@7ID
CAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAAC
+
CCCFFFFFHHHHGIIIJIHGEHIJHIJJJJFHIGIJJJIIJJJJJIJIIJJIIJJJJJJJJDGHIJIIIJIJJJJIHGHHHHCFFEFCEEEEEDCCDDD
@7IE
TTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGN
+
@CCFDD?BFFHHHEEGFHFFEB;FFHIGHDFHHIGGIGIEHB@?FHGIGGGHIIGE@FHIGHGAEEHA??E;@BCCC?CCCC?BBCDACCCCBBAA??@A#
@7IF
CTTTTCTAACTCTTCACAACGTATTCGATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAA
+
???BB=AA=:A??:??:A?F?333:CC<CC:9:1:11???*:B6D<<9?49D9??@D??/=C)BBCEI>C;==6.77?D;)=A73?D>.)((.6.55;>
@7IG
CTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCAAAATCAACTGTTCTTGCTTACTTTCTTCTCCAACAGTCATATTTTN
+
CCCFFEFFHHHHHJJJJJIIIHIIJJJJJJJJJJGJJJJJJJJJDHIJIIIJJJJJJJJJJIJJIIJIIJJIIJJJJJJJJJIHHHHHHFFFFEEDEEFE#
@7IH
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFDDDHHHCFHGHIIJHIHHHHIJGIGIGGIIIGHGHIEFGIIJJJJJJJJJJEHHHHHHFFFDDCEDCEDCCDCCDCCCDDDBBD<A@CDDDDDD
@7II
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAGTCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
CCCFFFFFHHHFHIJJJJIIJJJJJJJJJJJJJJJJJ>FHJJJJJJJJJJJJJJJJJJJHHHHHFFFEEDEEEDDDDDBDDBDDDDDDDDDDDDDDDDDD#
@7IJ
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJIJJIJHHHHHFFFFEFFDDD>BDD@CDCEDDCDDDBDD#
@7IK
GTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATAAGGTTCACATCAGGAAGGGTAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJHHHHHFFFFFFEEEEEEDDDDDDBCD
@7IL
CCTCGGTCGTGTAGCGGTGAAAGTGGTTTGGTTTAGACGTCCGGGAATTGCATCTGTTTTTAAGCCTAATGTGGGGACAGCTCATGAGTGCAAGACGTCTN
+
<@@DADAADFDB>CFGGI11??C?C@10?BB?B@BBFG6-<B;@@8467.7777?C;@@>BAC3;;>@::@5;@?>0<@@?CC<4+4:(::4:@CC5+5<#
@7IM
GTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACN
+
@@@DDDDDHHDHFHIEAG??C;CB?HH@9FFFBC:FDCB?9DB<BG@9??;BBB9CCCB=8=FHI37767CH=7;6;;;7;;>C@6;@CBBB,859&43>#
@7IN
CTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTN
+
???DB4B42C:<<2CE:A<:,3<ACFFE;?F?A<2AE?99:E1)11?:0?:::D@DBDIIIA?88BC8C)=8CC@.@A8....)=7AA=C7.=?;A>?DD#
@7IO
GCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTG
+
CCCFFFFFHHHHH<<>AFHIJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJHHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDEDDDDDDDDD
@7IP
TCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGN
+
CCCFFFFFHHHHHJJJJJHIJIIJJJJJJJJIJJJJIJJJJJJBFHJJJJJIJJJJIJHIIHHHHHHGFFFFEEEEECDDDDDDDDDDDDDDDDDDDD9A#
@7IQ
CTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCC
+
@@@FDFFFHFAFHHJGGIGIJJJEIEHGJJJJJJJJJJJIGHHIJGEAFHJJIHIEHEEFFFCECECEEDBDDBCCACCDDD>CCBBDBDCDDDDDD
@7IR
CGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJHIJJJJIJJIJJJJJIJJJJJJJJJJJJJJJJJJJJEHHHHHFFFFFFFEEEEEEDDDDDD;ACDDDCDDDDDD
@7IS
TCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGN
+
CCCFFFFFHHHHHJJJJJHJJJJJJIJJJJJIIIJJJJJJJJJBFIJJJJJJJJJJJJJJIHHHHHHHFFFFEEEEECDDDDDDDDDDCDDDDDDDDD9A#
@7IT
CGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGN
+
@@@DDDDABDDHHIIIFGGIIGHGEBDHHBFIDHDHHIFEDBEHBGHE4BCHIGFH>=CFCCHDGHHHFHEC@D?CCDC?;;@,8?;BCDCC:@CCAC:@#
@7IU
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHHHJJJJJJJFHIJIJJJJJJJIJJJIGIIJJJJJJIJIIJJJIJJCFGIJJEHFHFFEFFFCECCE;?B;CCCEEDDDDDDDDDCCDD
@7IV
GACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCCCTGCCTCTTGACTGGCTTCAGGCAAGGAGGAGGCATCCTCAGTCCCCATGN
+
CCCFFFDFHHHHHJIJJJJJIJJJGIJGJJJJJJJJJJIJJJIJJJJJJJJJIIIJJJJGIGIJJJIIEHHHHHFFFEDDDBDDDDDDDDDDDDDDDCDD#
@7IW
TGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTN
+
@BCFFFFFHFHHHJJJJJJIHIIIJJIIIJIJJIGHIIJJJJJJJJJJJJJJIJJJJJJGIJJIFHIGIIHEFFHHHFFFFFFEEEECDDDDDDDBD9@<#
@7IX
GGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTN
+
CCCFFFFFGHHHHJIJIJJJJJJJJJDDDDDDDDCD>CDDDEEEDDDDACDDBDDDDDDDDDEDDDDDDDDDDDDDDDDDD>BDCCDDDDDDDCCDBCDC#
@7IY
CTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGN
+
???D4B?BC8DB32A?EBE<;FAAAA?C@D86)?6)9?@B;BD1@;CADAA7.).=;>A@DA>83;8>BAA>A(,5;>A<??188<<<::A(2(8<>:><#
@7IZ
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
CB@FFFFFHHFHHJIGGIJIGJHJJJJEHIGDFDHIDHIJGEBGHIGAEFIJJIJJJGJJHHDHFFFFFFDDCCDDBADADDDDDDEDEBDDDDDDDDCD#
@7J0
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGCGGCTGCTGGCTGCTGCCCN
+
@@@DDADDFFFBB;@:G=G>C>A2+A??FBD:;;1:::D??:09D0?BBBFEF==B8CF>F@EEDB<45=>@CCA3((--((,2;>9?:@+038<(+:<@#
@7J1
ATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHFFFDDDDDDDDDDDDDDDDDDDDDDEDDDD#
@7J2
CTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGN
+
CCCFFFEFHHHGHIJJGIHIGGHHHGIJIJIJJJJJJJJJJJJIIIJJJHIIJFHGIJIJIGGIE@EHHEHECHEDFFFC>CDEECECACDCDD;?ACC@#
@7J3
CTGGCATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTN
+
C@CFFFFFHFFHGJJIIGICHIIIJHHIJIIJJJJJJIIJJJIIIJIIJIJIHJJ?DHGHGIHIGIIIIIFFHHEH;BDFDDDDDBBD09>CCDCDDDCC#
@7J4
CACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTN
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJFHIIHIIGJJJIJJJJJJJJ=@EEHFFFFFE>CEEEDDDDDDDDDDDDDDDD#
@7J5
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
@@@FFDFFHHHHHJJIJJEHJIGIBHIIGHIHIIIIJJGHGIIJGHGHJJHIIGIIJJIIIJJJGIHEDFFDAAEE>CDCD>CCDDDBDCCBCDDCDDDD#
@7J6
GACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTN
+
@@@DDBBDFHDAHGHIIIII?FGGGIIHGGIFIIIGCHIIEBC?BBCC?CBDDCDDDCD@BCDCBCCACBBDDDDCAA@C>AC:@CC?>CCCCCC9ACCC#
@7J7
CAGTGGTCTGAGCCTGGGTATGGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTN
+
@@CDFFEDHHHHGGIGHIGGICHIDFEGGHGEGGIIGGGICGHGHHGJDFDHC>FHIEFG@GHEHCGHIGGGC>EEEBEFCACCC@CDEEACC@DDC@C>#
@7J8
AGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCN
+
;=@DD>@DF??DF?AEAAF@39C?92:9C8)CDADGF<<D?FEFGEG@F:6;A;@F@E==DF2;?9@883<-<@4>4A4>:ABBB9B-&2+:8>:AB:@:#
@7J9
ATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTCAGCACCCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTN
+
CCCFFFFFHHHHGJJIJJIJJJJJJJJJJJJIJJJJJJJJJJIJJJJJIJJGIJJJJJJIIIJGFGIIIJJIIEIHHGHFFFFFFEEDDECCCCDDDDDD#
@7JA
TTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCA
+
CCCFFFFFHGHHGJJJJJJJJJIJJJIIFFFHIJJJJJIJIJJJJIJJIIJJJJIJJJJJIJJJIJJJIJIGHHHHFFFFDDDECEDDDDCDDECDDD
@7JB
GTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGAC
+
CCCFFFFFHHHHHJJJJJJJGIJHIJJJGJJIIJJJJJJJIJJJJJJJJJJJJIJJJJJJJJJJIJJJJGJJJIJJJJJHHHHHFFFFFFFEEEEEED
@7JC
GTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTN
+
CCCFFFFFHGHHHJJJIIIJJJEGHJJJJJJHJJJJJGHIIJJJIJJIJJIJJIJJGJIJIJJHGHHHHHFFDDDDCDCCDDDCDCDDDCDDCBDDDCDD#
@7JD
ATATTCTATCGGCAAAGCGGTGTTGATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTG
+
@@@FFFFFGHHGGIIDDEHGHGIGIIIGGIIGIGFFIDFGGIJJ@AEGIEGHJGHHHHFFFFFDDEEDDCDDDDDDDDACDCCDDDBDDDCDDDCCD@?
@7JE
GCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGN
+
@8?DBA?=AACFFGGGDFHC?FCHG9FEGH>@F@BDGDGBGCHEHEHCG*BFGGCHIIIIIEHEGII7;A4AAE?;@>BCDCCDCC6>5@BB=CBBB?@B#
@7JF
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGN
+
CCCFFFEFHHHHHJJJJJJJJFHJJJJJJ?HHIIJJJJJJFHIJJJJJJJJJJJJJJJJJJJBEEFFFFFEEDCEEDDDDDDDDDDDDDDFDEEEDDDDD#
@7JG
CACCTCGCTCTCCAGCGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCN
+
@@@D?DBDF?D+<E@GGAGHHIGGGIDEFBB?@@;@BFB;@<8BEDE?A@ACCBCCCC(;@CAAC9?218;@@(44:<<-0<@CCCC<?<??8@95.5@@#
@7JH
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@@FFFFDAHAFHGEGGCHHGHGII@FH?FGGHHHGIGGBGGGFGGEHGGIGGHGEEF?CDDCEEECCCCCCBACCCCCDDCC>>AC@C38>CB>@?(
@7JI
GCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
CCCFFFFFHHHHHJJJJJJJJJJIJJIJJJJJJJFHIIJJJJIIHIJJJJJ@FHJGHIHHHHEHFFFFDDDDDDDDDDDDDDDDCCDDDDDDDDDDDD
@7JJ
CTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
@@@DD?DBDH?@A:E@D?E>F<FE<<<C@H@GB@BB<DEC9?*:DGH@B?8B8=CBB88@3=FCDEHI>-5=B3;;;A>>3:<958-?BBB:4>?BC>
@7JK
CCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCACGCTACTGGGGTGGTCCN
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJJIJHIJJJJJJJJJHIJJJJHHFFFFFFEEEDDDDDDDDDDDDDDDDDDDDD(5@DBDDDDDB5>B@CD#
@7JL
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJHHIIJJJJJJJJJJHIJJJJJIJJJJJJIJJJJJJJIJJJGHHDFEFFDEEEEDDDDDDDACDDACDD8ABD
@7JM
CTGCCTTCTCCTTGGGGGTCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTN
+
@@@DDDADHHAFHHGB@@CFEEHCDFHGCHHI@EDBGIDBFIGHBGBFHGGEEGIC>EECDEECC>CCC6?;?@B@BA>CADCCCCCCCCCCCACAABC>#
@7JN
AGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTA
+
;?<DB3D;==??F@@<F;:??A<2CCEEBEDB8:?8:9?;;??@FAF@=76@;66:B3=9?;;;?BBB;A>:A:ABBB?B?B?@2<>2?B>@BDB>ABB
@7JO
GGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTN
+
@@@FDFFDGHFHDIIIIGGFHHIJJIGIGGIGIGIJJIJGIFGDHHGIIDHGIGJH>CDDCDDEEDDDDDCDDDDDDDBCCC>CB3<BD8??@BD<BBAC#
@7JP
GCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJIJJJJJJJJJJJJIIJIJIJJJJCGIJHHHFDDDDDDBDDCDDDEDDDDBDDDDDDDDDDDDDDDC#
@7JQ
CTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATN
+
@@@D?DDAHBFA>E@:?AFAEHAFFGIIGI@CFFGHC?9:C?F3:D?D?DBD?*9BGEBFCFE<E=-7??ECC>7@C;B@;3;;;3;ACC:;@>ACC:;;#
@7JR
GGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGN
+
@@@DD@'38>>AABACCBBCA>@<88?C>>8>@CA>CC><CABBBBBAA@>CC>@CCCCADCA>CDACCCCA>:@:@CCC@CC>>CCBCCC@@@>AC>C:#
@7JS
TTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGN
+
@@@FFFDFHHDFDHEIIEGGHIHIIJIIIIEFGHIG<BGGGHBDGIIGIIFHHHIGGIEHIGHGHFEEFFEABEEDDDCCCACE:>ACCCDACCCCCDCC#
@7JT
TAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGN
+
BBBFDDFFACFHHIIIHIJCGIGJHIJJJJIJJJGIJJJJJFHHIJJJJJJJCFHIJJIHHHFFFFFEEEDEEEDDCDDDDDDDDDDEEDDDDDDDDDDD#
@7JU
CCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACA
+
@@BFFFFFHHFFHJIJJIJJJJJJJIJGGHIEHIJJGIJJIJGIHGIIIHIIJJIBGIIIJJJJJIJIJJJIJJJJJHEHHHEFFEFFFEEEEEEDDDD
@7JV
GTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATN
+
@BBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIIJJJJJJHIJJJHHHHHHHFFFFFFEE#
@7JW
ATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTAAAATT
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJIJJJJIJJJIJJIJIJJJIIJJJGJIJIJJHIJJJJIJJJIIGIIJIIGHHHHFFFFFFEEEEEE
@7JX
GGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCTATTGTGTTTATATN
+
CCCFFDD:BDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCDDDEDEDDDDDCEEDDDDEDEEDDDDDDDDDEADDCCCDDDDEE#
@7JY
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
CCCFFDFFHHHHHIJJJJJJJJJJJIJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJ@FHHGHHFGHHFFFFFFFEEE@CDDDDDDDDDDBB#
@7JZ
TTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATGTGCCTCCTTCAGGN
+
@@@DDD?DHHHHF2AEGIIIIGHEFDHIIB>DD?DDHGEGBEFBGGIGEDHHIEGFGHGFF@AHIGDDEEA=AHF>:CB?DCCCCCCACCCCCBCCA@>C#
@7K0
CTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGG
+
CCCFFFFFHHGHHJIJJJJIIJJJJJJJFHIIJJJJJJJJJHFFDDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDEEEEDCDDDDCDDDDDDDDD
@7K1
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCN
+
@@@FFDDDFDHFFIIGIGI?BEFIIGHGHGGGIGGHJIIEBFEGIIHBGGG@GCHIGJIEIIIGBDAGGGHHF5?AACEEDCDB5?CDCCCCCCCABCB?#
@7K2
AGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTN
+
@@CFFFFFFHHFFGEHIJJIIIEGIJIHJJJIJGHHEGIIJIJJJEIIIGGGIGBFHJJJHHHFFFFFEEEEDDDBBDBDBDDCDDDDDDDDCDABD?@C#
@7K3
CAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGTGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTN
+
???1A+2=CA?B12<+A<BB<FFEDEE@<DDDDDBDB933@A3?D@D'@8;(737A7.)7;;6=??>?5;&++:2938<>79<)50(+2>8000;??;;&#
@7K4
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
C@CFFFDEHHHHHIIJJJJJJJJJIJJJJJJJJJJJHGIIJJJJJJJJJHJIJJJJIJJJJJJJJJ@GIHGHHGHFDEFFFFEEEDECCDDDDDDDDDDB#
@7K5
GCAAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHEHFCDFFDDDDDDDEDDDDDD#
@7K6
CCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJIJJJJJJJJJJJJJJJIHIJJJJJJJJJJJJJJJJJJJIJJJIHHFFFFFEEEEEEAEDEFDDEEDDDEDDDD<#
@7K7
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
@@@FFDDFHHDFHJEEBGGIAECHGGBEIIGGGBBD?DBBG@GDFHI@DGCFGEGE=ABGG75??;B>?CCEEECAA.=;9>ACDD@CCD@????@@C@
@7K8
ATTTGTACAGGCAGCTCCAAGCCTACAGCATCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGN
+
CCCFFDDFHHGHHJJJJJJIJIJJIJJIJJJJJJJJJJJIJJIJJJIIJIIJJJIJJJJJJJJJIIJJHHHHHFFFFDDDDDDDDDDDDDDCCCDCDDDD#
@7K9
GCCTGGGGGTCCTCTGGACACAGTTATCTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJHHHFBEEECEBFFEEDDDEDEDEDDD<@DDDDDDDDD@C
@7KA
CCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTCCAATCTCGTCGGGGTTGG
+
?@@DDDDDAFFH?AFHBGIIIII>1?CDF@GHG<GGDFHCCC8BHDHI@;@.=;DHB:<AACC@CB(5<ACCCCCCBB<CCDCCCCCCB@8<<<5909@
@7KB
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
@@@DDFFFDHFDHIGIIGG<ACFIGEIBED<?EBDFBGFHIICGGGGIC9DDF>FGHIFFGGCGE:=@EHHHHE@>BFE>C@CEC;>?>AA:9::>::@
@7KC
GGCATCATTTCCAGCAGAGACAGGAGATTCTTTACTCATCAGCTCTTGAATGGCTGTCATGACAACATGTTGAACAGATTCCTCCATCATCATAATGGCTN
+
@?@DDDDDDDHFDDBDHIJJGEHDEHBFHEGGAAGH@GIGIGFGFGGHEHIJHC@FGBE=FHIGIEGIJ@HCHGA=??EHC@BCDECA>>;;@ACDCC??#
@7KD
GGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCCCCCGCCATGAGCTCCAGCAGGATGAACCGGGGCAGGGATTGCAGGCTCN
+
CCCFFDDDDHDHDEFGHIGIJJD;>CDDDDD?98<BA??ACCCDCC8<CDCCDBBDDDBBCDCD<CDDDDD@BDCCCDDDDDD<BDBDDB?CDACDDD?B#
@7KE
CTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCN
+
CCCFFFDDFFHHHIIJJJIJIHHJJIIIJCHCFHGIIGGHIIGIGGIJIIICHIIGEHID=@G@FHGEHGHEFFDHHCBBEFEFFDEC@CEEDDDDCC?A#
@7KF
CGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTN
+
@BBDFFDDHHHHHIJJJJJJJJDBDDDDDDDD:BDDDD6<BDEEDEDDDDDBDDDDD5BD<CDDDDDEEC@CCEDDDDB@DDDDDDDDDCDDD?BDDDD@#
@7KG
GTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGG
+
CCCFFFFFHHHHHJJGIHIJIJJJHIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJHGHHHFFFFDCCEEDCDDEDEDDDDDDDDDDDDDDDD
@7KH
AGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCN
+
BCBFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFEEEEEEDDEDDDDDDDDCDDDEDDDD#
@7KI
CCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGN
+
@@@DD?DDHHFHDCDE?CHHIIIHGIE8HHGGDHFIEIIEHIBEBC;B@BDDACACCD@CEDC@BDDABCCDDD9>BDDDDDACCCCCC>CDDDD:CCCB#
@7KJ
AGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCAT
+
@@CDFDFBHHFHHJHIIJJIEHIJJGIIIJJIIGBGIHDFG<FEGFHFDGFGEDHGD@DEHH=?@>BDFFEDECCED@CCBDDDDDCACC>AAACCCD
@7KK
GTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGN
+
CCCFFFFFGHHGHIJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJIJJJJJJJJJJ=BDAEEEDCDDDDDDDDDDDDDDDDCDDDDDDDDDDDDC#
@7KL
GTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGT
+
@@@FFDDFFHGDHIGGFGIFHHGGIGIIGEIIIFHIFIIIIGIGGIGAHHAEC?CCHEFCDBBCECCEDCDCDDCDDDBDBBBCC@CCC<ACADCCDD>
@7KM
AATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCN
+
???DDBD;?:D>DE+??@E@?ECFEEIIIEE>EI;??BDIIIEEC@DEECEA89BCB=BCDIDACC>DEC7@CDDCC><4??@ADE>AA?AAAA>AAAAA#
@7KN
CTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGG
+
C@CFFDD?FFFHGICHGEDGCGGDGGEHE<CGFHGECHHIGHHG>?9BGBHDBDGGCGGGIHHIGGGGFEFFH>BEDEFFFEEEEEECDDCDCDDD
@7KO
GGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGN
+
<@@BDAD?F?DFFIHGIGGHBFHGHGGG>BHGGIFHG@FGC@=FHECFA>DDH@GCHEEEEE@CCDBBCAAC;ACCCA>BC@@ACCC:8,5>@DEEEE>>#
@7KP
GGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATN
+
?@:DDDDDFDFFH@BEEGGHCGIGIEICEEHECEBEDFFGFGEFE@F9BGGGGECGCGGCHIEDC7A;???@.>@@:C?B@3;@>CCC9;<9A8>:CCCC#
@7KQ
GCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGN
+
=;=DA2=BB=CD?EBEECAEE??B::EDDIEEDIE@DDID?DD;BDDABAEACCCCC7>?DCCD=/(=>;>@A;B>>>>>;>>AAAAA>;5:;5>>9>A?#
@7KR
GCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
BBCFFFFFHHHHHJJJJJJJJHHJJJJJJIJJJJJJJJJJGIJJJGIIGIJJJHHGFHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDD#
@7KS
GTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
;@<D;D)8AF<FFG9EFAEGG<GFHIIBFDE>DCDE?<??*0?88CBFBA9@54@D=AC>;E>BDE/5;9;8::>@?BB??44:(4::::4(:@B>99<<#
@7KT
GTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGN
+
@CCDFFFFHGHFGHIGAFICHG3CFFGIIGIJJJJGIJG?FEEIG1BDHHIJGHGIJIGGBFHI=C=CEEACEE@@;;BDDCCEEEDDCDC=@CCCC?BD#
@7KU
TTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATN
+
CCCFFFFFHHHHGJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFDED>CDDDEDDDDDDCDDDC#
@7KV
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJDHIHIJIJJJJJJIJJHHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEEEDDDDDD#
@7KW
AGCTGCCAGATCCCTGTGAATGAAATGCATCCGTTCCAAGTAGACACAGCCTTTTGAAATATCTACACACAGGTCTACAAGGTCAACCAAGGTGAGTAA
+
@@CDFFFA>FHDFCHIBHEIBHHIIGGFBCHHIGHIGGAGDEBDFGIADHHIHIJCBEGIJIJ@FAEADHIHCHEEFGFFFFFDCCE@BDA?AACB>>C
@7KX
ACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGN
+
CCCFFFFFHHHHGJJJIJJJJJJHIJJJGJIJJHHHFF>BBDEEDDDDBDDDEDD@CDDDDDDDDDDD;BDDDDDDDDDEEEDD>CDDADDD@BBDDDCD#
@7KY
CCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACA
+
CCCFFFFFHHHHHJJJJJJJJIJJIJJJJJIIJJJIJIIIJIGHIHJJJJJJJJII@DHGIHHHHHHFFFFFFEDDDDCDDDDDDDDDDDDDDDDDCD
@7KZ
GTTTTCCAGGCATTTCACATATTCTTTCTTAGGAATCAAACACTTTTATTGGAATAAAGATCCTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTN
+
CBCFFFFFHHHHHJJJJJJJIIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJIJJIJHHIJJJJGGGIHEHFHHHFDEFFFECEEEE#
@7L0
GTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTC
+
@@@DD?DDB;AF<<AACADHD?CFFEEC?ECGFF@FDGGFHB?D<?FDDBBG@FGHIFAFH@FD;@==CE<=BD7>;;CC>CD@5>?C?<A@@CCC@CC
@7L1
GGGTGAATGACAGCCTCCACCTTGGAGACAAAGACCTTCTGAGAACACAGCTCATTGATGTAGCTCAGGAGACCTGGATCTGGATACATCCCTTCCTCCTN
+
B@CBDDFDDHHHHIJJJIJJJIIJIJJGIJJIHHIIIJIJIHIIGIJJJJFIJJGHHCCHFHIJJIJJJIJFHHHFF@DCCEAEEDDDEDDDDDDDDDD?#
@7L2
GCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGN
+
@@@DDFDDDHHDHIGIIIIIJIHHGHHEHGGIJJJJJIIIIJIBFDFGIIIIJIJ?EHGIIIIGIIIIJJJIIJHHHFEEEFBCACEECCCDDD>?>CDD#
@7L3
CGGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGG
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJIJJJJ?DFHJJJJJJIJJJJJJJHHHHHFFFFFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDEDD
@7L4
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJHGHHDFFFFFEEEEEEEDDDD8?BD@DDDEDDCD#
@7L5
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGN
+
C@@FFFFFFFHHDH@FFFB@FADDFHIBHEEH<EGE<CFBAGFHDGIGGGIEGIIIAHFEHDBD@@B?=CCCCCB@BCCCCCA?B??<?CDDECCCCCBC#
@7L6
AGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJHJJJJJIJJJHHEDFFFEEEEEEDEDACDDDDDDDDDDDDDDDDDDDD8ACDDDDDDDDDDDDDDDDDDDD#
@7L7
CACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTGGGTCGTTGGGCATTCCGGACACCTGGCCTTCATACACCTCCCCAAAGGCGCCATGGCN
+
@@@FBDDDF?>D=CEGHIIIIGGGHFGEED>DFCGIGIGH@FHIG57:9B@B>;CC>@@C:6?B?8>9A<<CCC4@ACCCCCBBBBC@BA9<99>>8@>A#
@7L8
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGTGGCCTGGGCGGTGGTGACTGTAGCN
+
@@@DB=D?::22:C:2CGIIII@8F?F??*:CC@GI4D00?00)//?8*/=.=B=8/7)/@6C7).?.77=)..7..,>6>5;5(')5&952++:3((+3#
@7L9
TCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGN
+
CCCFFFFFGHHHHJJJJIJJGJJJJJJJIIIJJJJJIJJJIHIIJIJJJJJJJIHIJIIGIIJIIIGJJHGHHGHFFFFFFEEDDD9?BD@CDDEDDCCB#
@7LA
CCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTTAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTAATCCTCCATCACCACGA
+
?8?D+ADD?<<,C<E?G:EGIIII<H32A<<*:*1C*11CG<C8B<DF?*00)(/.7'')&)0(+:A(+893?2A2>BB(+(4@BB3@3?:3(:(+8+9
@7LB
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGN
+
CCCFFFFFHHHGHJJJJJIHHIIIJJJJJJIJJIIJIJJJJJJJJJJJJJJIGIJHIJJJJIIHHHHHHFDFFFDEEEE>CDDCDDD5?BDDDDDDDD?B#
@7LC
CTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGCTATGTTTGCATATCTCCTGATN
+
<;?7?DB?A;A;+<CFFF>F;31C>E9C>FFFEDCG8C1?DB:06BF7(8?B=.88<=)8).@8=7777=CC/?BB>.(.6;;5;>->>>;@AB:@::>>#
@7LD
GTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIIJJJJJIJIJHHHHFFEFFEEDEEEDDDEDDDD8?BD>CDDE
@7LE
GCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJIHHHHHHFFFFFFFEEEE
@7LF
CTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTTGN
+
BCCFFFFFHHHHHJJHHIJHIJJJIIJJJJJJIJJJJJJJJJCGHIIIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJIIJHHHHFHFFFFFFEEEEEEED#
@7LG
GTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATN
+
?@@DDA=BD<FDHGHE@BHCCCHEDHGGIFBCHE6@F67;FAEE58BCC>AC@CCC>AC@:?BB8>7>@5@AC@4<CCCC>>A::?<?<&090<B8@ACD#
@7LH
TGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTN
+
::8:D;BBF>FBFFII<?F<B@:+<F49<?A@G@FDB?GFFEB??@FB?FFI@)=BCF)@C)@DEE<DEAEFF357;A;7@DE;666@D?B=;?>(998?#
@7LI
TGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTN
+
@@@FDDFDHHFFFGIHDHGJGIIJIJIIGIIJGGJIIHIIIIJJJIEEHICGIJJJIJIGJJEGGJIJGIJJJJEHGHHHGFFFFFCCEECCCDADD@C@#
@7LJ
GTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTN
+
@@@DDDD;FF;CAGBGBBFDH<22<F?92?FB9CGEICGFBGEFA???DBB@??FDFCD4B8CCFACDFEFEIAACEC?;;BCCACC;>?;A==(5<9=<#
@7LK
CGGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTN
+
?;;BDDDDFHAHAF@BAC@FFHFEEHBBB:DDBCADBGAGG@GIGGGHGIIIIA>CEEBDE@ECCCCBB?=?>:>::5<?,59@AC<C@>?@9@<ACC>@#
@7LL
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGAGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
@@?ADDBDHDB??CHHGHGEEBBHDH@DEFDGG;FFCBGIIDDHBFHDH@@DF(7;F5=DHIEECHHF??3=A;;5>@BBCCCCC@CCCCC@CCBCCCCC#
@7LM
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
?@@DDDDDFHFAF<BFGHGI@FGGE3CFGGGA<@??FE<BF@B;FBBF@BFHIGG>GH@EIFHB'9>>5;@>-5<==B@CCCC@A@AC<>C?@<5@BBC@#
@7LN
GTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTN
+
C@@FFFFFHHHGGGIJHHIJJJIJIGJJJJIIJIIIGGIGEHEGIJGGIGJHGHIJJJJJIGGGGHIJGEEEEFDFFCEDECCBDBCDCCDDCDDDDDDD#
@7LO
AGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCN
+
CCCFFFFFHHHGHJJJJJJJJIIJJJIJJIJJIJJJIIJJJJIJJJJJGJJJJIJJJ@FHBHHAEFFFFEFFEEEEEEABD@CDDEEDDDCDDDDBDCDD#
@7LP
CAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGN
+
C@@FFFFFHGFHAFHGGHEHIGGGGIJGGHIIJJJJFIJIJIHIIHHGHHIHDECFEFDEEEEDD?>CDCDDB<ADDDDDD:CCDCBDBB9BDDDDDDCC#
@7LQ
CCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTN
+
@@@DDF??FDFHHFGIIIG@@HIBGGCAHGGGIIIHGHIEIEHIIIICGIIIIIIGICGHBHGHIIGGGIIIIIIGDEEHFCHFEFDFFECEECCCCDCC#
@7LR
TTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCCAGTTCCACAGAGAAGCCCTGCTCATGACTN
+
@@@ADD>BFFBDDEH@HGCHHIIIIIICDCBEGIIEAFECG?DFHGGFBCGHHHB;BCGGIIIICHE>FHIGIEGHIIGHHCHFE;;ACECCCCCCCCCC#
@7LS
GTCTCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTN
+
@@@?:=B?<D<FF<?:CF?H+CF><G<<CF@4AEHF<*?<C9DB??D>DDCGICIEA@FFF;B>D<CFDE@CGIEED@AC@CDD;?B;?@AC(666>;;3#
@7LT
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@@DFDDDFDHFHHJJIGCFHICGGGGFHBGIGGHGIJJJJJIJJJJJJIJJJHHHGHGEFFFFDEECEEDCDDDDDDCDDDEDDDDDDDD@D85>BDD
@7LU
CATCCAGTCACGGGAGCCCTCCCTGAAGAATTCCAACCCCGACGAGATTGAAATCGACTTTGAGACCCTGAAGCCGTCCACACTGCGTGAGCTGGAGCGCN
+
CCCFFFFFHHHHFGBEFHHEGIIJJEIGGIGCGIGGIJIIIIJJG@AEEEFFFFFDEBBDDDDDDDDB?CDDCDD@>DDDDDDC@C<9>?BDDACAD?9B#
@7LV
CTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTN
+
@C@DDEDFFDDFFJGIJFIJGGIJJAHFHHIIHIJJIJJJJIJJHHHHDFFFFFEEDCBBBDDDDDDDDCDDDDDDDCDDDDDDCDDCDDCDDCDDDDEE#
@7LW
GGGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCT
+
@@CFFFDDDDFFDFIIGGIEFGEHEHGIGIGFIIGCGHGIIJJ?G@BF?F@DBCGHEHI7=C7=CCC;AEH==;;BB;@=596;=?A>@CC?55>@@A@
@7LX
TCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGN
+
@@@DDDDDHFAA<<CF??@FG<?:?;;FBDHFG=F@HIE<C8@@D@@=DHEEGE>?=EHBBD>;6>>66;A>C@>@DCAAC:::,<=?9>BCC@>CCAA>#
@7LY
GTCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGGGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGN
+
?@;;BBD?<<@8?<FDFACBC<E2?FED81*?D)B=139<BFF3B<B9BAFFCDCEE7)6=2(6;(,9=1>3(-(-(5<@>AB>:3>:3@(>33980:<?#
@7LZ
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
CCCFFFFFHHHGHJJJIIJJJJJJICHHIIIJJ?DGIHIJIEIJBFIIIHIJJJJJJJIHHHHHFF@ADEEEDDCDD>CCDDDDDDDDDDDDDDEDEEED#
@7M0
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@@@DDDDFHHHHHIJIGIGJJIGHIGIIJJIEIGIJJJGIIFDHIJIIGIGGGGGIGIGIJHHHDBCDDDDCCDDBBBDDDCCCDCDDDDDBD@9@BBDC#
@7M1
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHGJJJIJIJJJJFHIHHIJJJJJJJJJJJJJJJJJIJJJJJJJHHHFFFFFFDEEDEEDDDDDDEEEEDDDDDDDDDDDDDDDDDDDD
@7M2
GCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACAC
+
CCCFFFFFHHHHHIJJJJJJJJJJJIIJJHIJIIJIJHHJJJJJJJJJJJJJJJHGHHHFFFFFFEEEEEEFDEDDDDDDDDDDDDDDDDDDDDDDDDD
@7M3
TCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTN
+
@CCFFFDFHHHHHJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIJJJJJ@EEBEFFEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@7M4
TGGCGTTTAAAGTATGATGTTCAGATTAATGTGCAACATTTCAATGAATTTTAATGCTGTATTAGCTGCTCACCTTTTGCATAATTCCTTTCTCATAGT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJIJJJIJIJJIIJJJJJJJJJJJJJJJIJJHIIIJIJJJJJJJJJJJJJJJJJIIHHFHHHHFFFFFFEEEEE
@7M5
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTN
+
CCCFFDFFHHHHHJJJJJJJJJJJJJIIJJJJIJJJJJJJJJJJJIJJJHFFDEEEEEDDDDDDCDDDBCBDDDEEEDDDDDDDACDBDDACDDDDDDDD#
@7M6
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFDFFHHHFHGIJGHHHHHGJJJIGIIGHIJGIJJJJJJIEGGHIEHGIIHGGGIGFGHGGHHIHEHGEBBDF7>CA@CDD5>@BDDCD>A@2<@
@7M7
GTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTN
+
B@@FDEFFHHHHHJBHGFFGGGIIFIIJIJJJGIIJJIFHHIJHFHIJIFIIHIHJJJJIIGIHHHEC@DFFFFEEEEDB>CDDCCCCCACCD>@ACD@C#
@7M8
CGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCAC
+
CCCFFFFFHHFHHIJJIJJJJJJJJJJJCGHHIJJJJJJGIJJJJJJIJJJJJJJJHHHFFFFFFEEEEEEDDDDDDEDEDDDDDDDDDDEEEDDDDDD
@7M9
ATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTGTACGACCACCTGATTGCTGGN
+
CCCFFFFFHHFFHJHIIGHIGHHIJIIIJJJGIIJ?DHIJIJGGJJJJJJIIGHIIIJIIGJJJIIJJJIHGHFHHFFFFEFEDDDDDDDDDDDDDDDDD#
@7MA
TAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATAACGGAGGGCCCGGCTCAGCTTGTCGTAATTCATGTTGGGCTTGCTTTN
+
@@@DAF?DHHGGHIFIGI@EAFEHGHIE3?FDGGGIFHGEIGIGIGCEHHIBHHGIEH<88AEHDFCCCACCCC>;>=@ABBDCCD:@CCCBBCB@?CCC#
@7MB
AGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATN
+
@@@FDEFFGFDFFGACFEHHIIEEGGCGGGHGIIIEIHBHGIIIGIIIIIIGGEH8AGIHGEHFFDCD>CCCCDDDDDDDDDDDDEEEDDCCCCCCDDDC#
@7MC
GTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTN
+
???AD@DDHDC<<CGCGHADDH@??FE3?GBD?B?B9??9B9?<90BDB?==BCFGH@7C@D@C=.56@D7;76>>@CA@@;;>;5>5:><<@=@5<?C>#
@7MD
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
@@@DDD?DCDBACGCEHHHIIGG<AFF<EFE?DGG9BFGBDDDBGIIGH>DFBGGGIIGHIHFF<??DCCCCCCB@@ACCCBBBB8ACCCCCECDEECCC#
@7ME
TGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCT
+
@@=ADDDDFFFDDHEFEGGDE@EG?=GGGHDDFFGIIIIBBFEGGGIIIHIHB<BCCEEECC@CCAC>AC5AACCCDDCACB??<BCB@B>?CDDCA
@7MF
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
C@CFFFFFHHHHHIIIGIFGHHIIJJJJIHHIJJJJJJJJJIJJJJIJJJIIJJJJJJHHHHHGFFFEECDEEDDDDD3=B9CDDDDDBDDDDDDDDDDD#
@7MG
CCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGC
+
CCCFFFFFHHHHHJGIJIJJJJJJJJJJJHIJJJJJJJJIJJJJIJJJJJJJJJIJJJIIJJJJJJJIJJJJJJHHHHHFFFFFFEEDDC@DDDDDCDD
@7MH
GTCGTATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGN
+
@@@FDDFEDDHHHIGHJIJGJIGGIEHHBHEGGIGHGGHEHIDGIJJIJJGIGGJEHHHHEEDECDDDDDCCDCBBDCCDCCDDACBDDDEDDDCCCDDD#
@7MI
CTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCN
+
@BCFFFFFGFHHHGIIIJIIJJIJJGIIGIJJGJIGJIGJGIIJJJHIIIEGEHGEGIIJJJJJJJJIJIJJJJIJIGHEHHHFFFDFFEEECDDEEEDD#
@7MJ
TTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCACCACCAAAACTTTTATTTACTTTAGCAACTGATCCTTCAGCACCCCTGCTTGTCATTTTCN
+
?;:DDD?A;C>:A+AC9,3AB:C<+<+<+AF?<EE?**1**1*0???DC)*****99)/)8B<=7))>88..)7@)).)..7.(5=((.5;(5((-(((,#
@7MK
GTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTN
+
@@?DDD=BBBDHAEBB@D8@CFEGGCHFBC3CBGB?BFDGGB<DD/?B=FH>G2C=7CG=3?=B55998918A<>(5>ACCCC9@C<>@>+989<93(8(#
@7ML
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
CCCFFFFFHHGHHIJIIJJJJJJJIJJIIIIIIIJJJJCHIIIJIHGHJIGEIGFHIJJJJJIJAGHGGFH5=AB;CDDECDDDDD?BDBBDDCCCDDCC#
@7MM
CCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJJJJIJJJJJJJJJJJJJJJFHIJJHFDDDDDDDDDDDDDDDDDDDDDDDDEEDDDDDCDDDDDDEDDD
@7MN
CTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTN
+
@CCFFFFDFFFFHB?AGHHFFEHHH>HGGGCECGIIIIID?F?DCBFF6@FGIG?ACEA@C;?B<8=B@DCD;0>BD?DDEDC:?CDDDDDDCDDD@CC>#
@7MO
GGCTCCTGAGTGGGGTGTCTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTN
+
CCCFFFFFHHFFHJJEGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFDDEEEDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDDD#
@7MP
CCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTG
+
CCCFFFFDHHHHHJJJJJJJJJJJJJJJJJJJJJJJJGHIIGJJIJJJIJJJJJJJJJIJJJIJJJIIHDBBDDDDDDDDDDDDCDDDDDDDCBBBD
@7MQ
GGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJIJHIIIJJIJJGHJIJJJJJJIJJJJJIJJGJIIJIJHHEHFFFFFEDDEDDBCCDDCDDDEDEDCDDDDDDDDD
@7MR
CCCACCTGCAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCN
+
@@@FDDFFHHHFF?CFGBHIBHIIEAFHEHGCGIHIGIIIIIIIGAHGGHFFHEFFFFFEECDCDDCDDD@;C>>CBDDCDCDDDDDDCDBDDDC@BDDD#
@7MS
TCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTTCCCAGGTGTGGGCTCTACAGTN
+
@@@FFFFFGHHHHEHFHIIJJJJJIJJJIJJJJJIIJIGHGEGIJIJJIIIIJHJJIHHGGIJJJJJIJJJJJEHIGIGIHFHHHBDDFDCB?BCDCDDE#
@7MT
CTTGACTGTCACTTGTATTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
CCCFFFFFHHHHHJJHIJJJJJJJJJJJJJJIJJJJJJJJJJJJJDFIJJIHFFEEEEEDDDDDDDDDDDDDDDDDEEDDDDDACCDDDDDDDDDDAC
@7MU
CTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCN
+
@@@FBDFFFGHGHIGIIJJJIJJJIIJJJJJIJJGJJJJJJJIJIJIGGIGIJIGGGGIIGIGGEGHHHFFFDECCCEECCDDCDDDCD@BCD5>ACDCC#
@7MV
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
CCCFFFFFHHFDHHIIIIJJJJJJJFHIJHGJJ:BFHIJJJJJJDGHJIIIJJJIJJJJHHHHHFFBBCEECDDDDD@CDDDDDDDDDDDDDDCEDEDED#
@7MW
ACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGN
+
@@@FDDFFFGHGHIJJIJIIGIJFGHIJGIIJJHGFFFCC@CEED@CB<@CDEDD>ACDCDDDBDC@D;@BCC><ACCADDEDD4@@B?BDDBDDDDD>C#
@7MX
GCTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCN
+
@<<;D?>4CDFFDE4;EAC>HGHIGCFAHGG@C9?GG<GEGGDFHIFFG@FH*99?FBFB4BFDGGIECH@CC@2;DE==@A>)=??=C;@EDCCA;;;?#
@7MY
CCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTN
+
C@@DDDDDGBHDFHIGEHIHGE@@GGIJJECHJJJEIIIHFHGGGFCHBGGBBHHGHHHFFFCDEBCCCCD@?@>ACCDDCDDDDDCCCDDDDD>CBBCC#
@7MZ
CTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCN
+
@<?BADB=CDD<C@FFGIHHBEA@G:?8EC?DF?BGGCDEFEH8?@FBB>DECFAD;=AE=??;@BA@BBCCAAB5>CC@C@C4:<B?A@CDADCCC?<<#
@7N0
GGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
CCCFFFFEHHHHHJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJFGHIGIJJJIJJJJJJIHHEHHFFFFFFEDDDDDDD9@B;@D9BDDDDD
@7N1
CTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGN
+
CCCFFFFFHFHHHJJIJJJIJJJJJJIJIJJJJJJJJJJIJJJJGHHIJJJHJJJJIJIJIJJJJJGJJJIJHHHHHFFFFFFFEDDDDDCDDDDDDDDD#
@7N2
GGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTN
+
CCCFFFFFHGGHHIDGGHFHJJJGHHIJIJJGEHJIJJIFGHDFHGHIIIJIJIIHIJIJGHJGHGGGDHHFEEDACEDEDDDDD@C>CAC>ADCCCDCB#
@7N3
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGN
+
B@CFBDFFHHHHHJJGIJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHHHHHFFFFFFFEEEDEDDDDDDDDDDDCDDDACDDDEDDCD#
@7N4
CATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCN
+
C@CFFFFFHDHHHHGIGGJFIIIIJIJIIJIHJJGIIGHIIJJJJJBHIJJJJJJIHHHHFFFDDDDDDDDDBBDDDD>CDDD??CDDEECCCCDCDD?C#
@7N5
GGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATN
+
@@@DFDFFGHGHHJIGIEIIHIGIJJIJIFHGGIFHIJJIJJIIIJJIICHIJGHGIEECAHGHHEBCFFDBEC?BACCCDDDDEDCCC?CDDDDDDCDC#
@7N6
CCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATN
+
@@@D?DB:CD?+AG@CF<<<CFA:CFHIB+A+@G@9EC<C?CFB*B9??FEF???999??B89B?B<BB=)=4.8CF;FFFII@7=C=7)77);.;?DD>#
@7N7
CTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJIIIIJJJIJJJHGIIJJJJJJJJJJEGIHHHHHHHFFFFFFEDEEEEEDDDDDDDDD
@7N8
GTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTGN
+
@??DDBDFHHBAFHGIFIIIBHIIGHGGEHIIGIGGGGHCBGIIGGEGIIIECHIICGHIIGIFGGFFFDBA;@CEADD@DA;@DDCA?CCCDBCBBACC#
@7N9
GGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATC
+
@@@FFFBBFHHHHGIEG8FGHGHIED@<>?FHE>FGGIIC;DDHGIJJJJJGCHGHBEBHFFBBDCCCEAEDEDD;=CDCDDA>?C2;5AB>ACC?<CC
@7NA
TGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGN
+
@@<DDDADF?DA6ABB66CC@8><>>@8@>@>@88<@@CBB?<@BB@>C@C>AC3@?3@+3>CCCC>@B-5>9@A@43>AC:@C(+(>CA4443>:AC><#
@7NB
GTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCN
+
CCCFFFFFHHGHHJJJIJJIIIIIJIJJIJJJJJJIJJJJJJJJJJIJIIIIGHIIIGIGIIIJJHIIJIJJEGGGHIJHFFFEEEEDDDDDDDDDDDDD#
@7NC
CCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGGG
+
?<;DABD??FFHFEBFEEFCACFHGIE@G?F:DFG<@49;36:<33>899@AC@CBBBB7;85;058585>;9&)&:489<905?AC32?<CABBBB&0
@7ND
GTGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTG
+
B@@DDDFDHHHHHHJJJJIIIGIE@FHIJIIJJIJGEHGHHFFFDBDDDEDDDDDDCDDDDDDEDCDDDACCDDDDDDDD<?DDDCCDCDDDDDDDDDC
@7NE
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@@@DBDDDHFFHHIEGGFI:EEH9?FHFCGGE?DAFFHDH>G<D;1BCEII3=@FGCGG<E)7=AEECDD>@;?65;C@35;>@ACC<@CC3:@CC>(
@7NF
CGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCA
+
C@CFFFFFHFHHGIIHHGGIIEIGJEIGIJJIJJIIJGHGIEGIIIIHGJGIHGIBHHJIHJDHGJIIJIFGHCHIIAGHGICCEHHHFFFDDCCECCD
@7NG
AGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCN
+
CCCFFFFDHGHHHJJJJJJGHJJJJIJJJJJJJJJJJJJJJJJJGIJJJIJIJJJJJJJJJJHHHHFDDDDDDDDDDDDEDDDBDDDDDDDEEEEDDEED#
@7NH
CATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTC
+
@<?DBDBDA??:AFHBFGGADHEHCBFBAHE>AFE4EBGEFC<DDHBAFEGGFAEHIEGH>FFHCC??)8BGCH<88=.87CC@7@==;A?EAA.7@3
@7NI
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
==@D==DDH?HDHGAE<EC;DHI@EFGFGE??>FDGHEBADGDEHGGGDAAF/?F6A;A@F)=7@CEE>;AHEEEED>>?;69>=5<85:@?:<<8<A
@7NJ
CTCTCGTGAGTGGTACAGGACTCTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGAGGGGN
+
@C@FFFDDAHHHFFEFGEGGHIGGIJJJIGECHIIGGHHIIB@FGIIHIJJIJIIGJIGII@@GHEEECACCCDEDECEDCDBBB?;@B@<@DDD3@BBB#
@7NK
CTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATN
+
?@@DADEDDHHHHHHBGGIGEFEICEEHHEGGDHHIIIIEHDEHGEHIIIGGGHIHII;C>CAHCEIGGHFGE?EAD@?BDBCEDEDFDE@CCCBCA@CC#
@7NL
CTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCAT
+
@CCFFFFDHFHHHJJJJAFHIJJFHHIJJJGIIIIGIIJGJJIJIIIHHIJHIGFGI@FGHIGHIJJJJIJHEHECEEFFFDDDDDCCDDDDFEEDCED
@7NM
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJHJJJJJJJIJJIJJJJJ@FIJFHIJJIJHIJJJHHFFFFEEEEDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDD#
@7NN
TTCTTTTTGAAGACTGTCAACTTTTTCTTTTAGCCGCTTATATTCAAAATCTAGTTTATCTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJHIJIJJJJJJJJJJJJJJIJJJGHIGIIJJJJJJJJIJJEHIIHHHHHEFDDEDEEEEDDDDDDEEEE#
@7NO
ATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTT
+
CCCFFFFFHHGFHJJJIIJI<FHIJJJJIJJIJJJJJIIHIJJJJJIIIJJJJJJJJJGJIJJIIGGHFHHDEFFFFFEEEECCEDCCCCCCCCDDDDD
@7NP
CTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCCAGTTCCACAGAGAAGCCCTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIFHIHIJJJJJJJJJJJJJHHHHHHHFFFFFEEEEEDDDDDD#
@7NQ
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGACTGAACTCTGCTGCCCGTAGCN
+
@@8ADDDDFBFBDGF@3ACF:<8?C3DDFIE>@*:?G>FDBAFC<BFFE37@;4C7)@=;AFFDD8'389::5(535/)&)+::@:3>A:>AB@BB5&(2#
@7NR
GAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTA
+
CCCFFFFFGHHGFJJJIJJJJJJJGJJJJJJJIJJJJJJJIHHBEDEEEEDDDDDDCD>ABACDDDDDEDDDDDDDCDDDDDDDDDDDDDDDDDDDDDD
@7NS
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGA
+
BBCFDDFFGGHHHIJIJJGEHIIIJJJJJJJIJGIHIIIIJJJJJJJIJJJJJJJJJDCDDDDDDDD>CDDEDEEDDDDCDDDBBDDDDDDDDEDDDC
@7NT
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
@@CFDFFFGHGFHIEEHIIIGGJJJJGGHGIJGGIJIJFIJGIFIIIIGIJGIEIJJIDIEEAC;?@CFEFFEECCECCCDDCCDDDDDACD?BCBDD39#
@7NU
TTCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
?@@DD;@DHA?DDBHEHGAHIGGGIGHEGDBBHHIIIDBCGEGIGIIEIIGFII@GECHGFEFFE=<>9ACCCCCBBBBBCCCCCCCC@CCCBBB@BB?:#
@7NV
CTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTN
+
@@@FFFFFFHDHDGHIJIGIEIGIIJCB:CFIHEHGGJJIGGGFCGE>FHI7=CEFGGF@EC?CEHDDDFFFA??CDDCDABBB;BDCDDDDCCDCCCDD#
@7NW
CCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCN
+
@@@DDDDDADFCHEA@GEHIGGDBGGHIIGGGIGGIGEIGIGGF@BGBFGFHAH@@GCGG@@FFEIIGCGHGCGFH@@G@CE>CDECDE@BCCCDCCACC#
@7NX
TGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJGGIJJJJJJJJIJJJJIJIJJJJJJHHHHFFFFDDD6;@=BD@DCDDDDEDDDDCCD4#
@7NY
CTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCAT
+
CCCFFFFFHHHHHJIIIJIIIIIIIIHGJHIGIJIJJJGEIJIJJFEGIJIIIJ8@GFHIBEFHHGHFFFFF);A;?B?CDDEEDDDDDDDDD@CDDCD
@7NZ
CTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGTTCTGATATGTTTGCATATCTCCTGATN
+
CCCFFFFFDHHHHJIIIJJJJJJJJJJJJJJJJJIJJJJIJJIIJJJJJJJJJHHIJJJJJJJHHCGHIHHHHFFFEEEEEFEEEEDDEEDDDEDDDDDD#
@7O0
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
CCCFFFFFHHGHHJJIJIJJDGHIJJJJJJJJJJJJJJJJIJJJIIHIIIIIHHHHHFFFDDDDDCCCDDDDDDDCDDDCDDDDDDDDCCBDDDDDDDDD#
@7O1
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCC
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJIJJJJJJJHHJJJJJJJJJJJJJJFHJJIIJHHHHFFFFFDDDDDDEFDEDDDDDDDDDCDDDDDDDDDDC
@7O2
ACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
CCCFFFFFHHHHHJJJJJJJIJJJJJGIJJJJJJJJJJJJIJJJJJJJJJDHIIIHEHHEFFFFFFEEEDDACDEEDDDDDDDDDDDDDDDDDDDDCE
@7O3
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
???DDDDA?D:42AEAEECEED>82?EEE@B@>D?0?DD?9BDEIII@@BCBCAC=@AC<CCDDDDD)?AAA<A??(3<A:>AAAA>>>:>>AAAAAAD
@7O4
CTTCAAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCG
+
CCCFFFFFDFHHHIGJJHIIHIJJJJIGHHHIJJJJJIIJJJJJGHIJIJJJJJJJJJJJJFHJJJJIJIIEGHHHHHHHFFFEFFFCEEDEEECDACB
@7O5
CCCATGAAGAGTAGGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTC
+
@CCFFFFFHGGFFIJIJIJJJJJFIIIIIBGFHIJIJIJIJHHGGIIIJJJJIDIIJJJJJJIIJJIJDHIGJJHHHHGFEFDFEECEEEDDDDDCDDD
@7O6
ATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCN
+
@B@FFFFDFHHGFIJJJJJJIGIJJJJJJIEHGHHIGIIJJJJJIJJIJHIIJJJIJIIJIJIJJGIIJFIJGFGFFFFFEEEEDEDDDDDDDDDEDDDC#
@7O7
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@@CFFFFFHDFD?GHE<AFEBBFEGDGCCBGHIECBG?DHICDFHIGHIIGIIHHDDHGGGCEH4=B3;ACCCCBBBB?ACC@CCCCC@ACBBCBB<BCA#
@7O8
CTGCTGAGTGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGAAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
???=DDA;+=AA<F?4AE?@AH?<CHDH32<22+@:D;8:BG4??BG?GFE@?<B;..=6.8/4'.--=;;;?@?(6>;;5>;(-59<?8(::38?B@
@7O9
CTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGN
+
???D?DD8DDDADAE9+233A;FD9<3C??EEEE>??*:BDDDD?DDEIAD0(((7=CADEC:))72?DD7=A?;?;6;@@@@>((-5(-(;:A555::5#
@7OA
AAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTN
+
CCCFFFFFHHHHHIJIJJJEGGIJIJJJJJIGGIIJGIJJJJIJJJIIJIIJJCHIIFHIIGGHIIIIHFFDC=ACDDEDB@?BDDDDDDBDDDDEEDED#
@7OB
CCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJIJIIIJIJJIIJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJIJJJIJJJJIJJJHGHHHGHFFFFFFE#
@7OC
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJJJJIIJJJJJJJJIJJIFHIJJJIJIJJJBFHJJJJIJJJJJJJJJJJJJJHGIHHHFFFEFEEEEDDDDDDDDD?CCDCDDD8
@7OD
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTN
+
CCCFFFFFHGHGHJJJJIIJJJJIJJIHIJJJJJJJJJGIGIJJJFHIGHIJIIJJIIJHJJJJJHHHHFFFFFFEEEEBDBDDDCDDCDACDDDACDDD#
@7OE
CTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCN
+
CCCFFFFFHHHHHHIIJIHIJJHIJIJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJIJHHHDDDBFCECEDEDDEDDDDDDDCDDDDDDDDCDCCDB#
@7OF
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@@@FDDDDBBBHHGHGFBHHICEGIIIIGHHFGGIIFGDHIIDIIIICGIIIII@DGGHGIII5=EF>CCCEEC;ABB9?=BBBBCCCBBCCCCACCCCC#
@7OG
CGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGN
+
CCCFFFFFHHHHHJBGIJJHJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJDHHHHHHFFFFFFEDEEEDDDDDDDDDDDDBDDDDD39B#
@7OH
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
??@?B@DDFDA?FGIGDCFGGIBFFEHGGIICG>F@FCHIAFHG>FHGIIIGE<@GHIHECEHED>A8>B:>CA@@?=B?@C@C@C>>:>>CC@B<<9@B#
@7OI
GTTAAATCTTCCACGGTCTGGCATGGTGCATCCACATTAAATGTCTGGATCCAAGTGAGGAGGCTCTCGCACAGCTCCGCCCGCTCCAGCGACTCTACGCN
+
@@@DDDEEFFDFG<CGAFHEGIIIIIAEFGHGGEHFFDHEHGGHC>?@GBFHGGHDDH@;F@@AHAGGACEDB@CCECBBBBBB?BB>>CBBB>>@A>85#
@7OJ
TTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAA
+
C@CFFFFFHHGGHJIIJJIJIIGFEEGDGGHHIJJIJIJJIJJGIIIJJJJJIGHHGHHDFEFDDDDDDDDDDDDDDDEDDDDDDBDDDDDDCCDDDD
@7OK
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
@@@DDBDDFDFCDGGHGIDHDFHHEECFFGHHGECDDEEGI?FHJJJGHGIIGIDDGGFGHGIGEDEHJGJ@=EDEDE;6A@CCCA>ACD;;;;?A@CBD#
@7OL
GCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGN
+
@<@D?D?;<AFC<?CCCEA?FE<?:A2<CA<9:E>?9C199C@?99BB99D399?DFEAF@G7/>E=;=D?===C77.;B6?>BCBB@590)+44:A3>C#
@7OM
CTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCN
+
@@?DDDDADF;AFBCACCGDC?CCEF??FDHBBCHID?GICH@G40999FF???BDC8=FDCCC@GAC=@G@GHE;=;6,?@>;>5=;A>;;>:@:A@>A#
@7ON
GCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACC
+
@CCFFFFFHHGHDHGIJGIIIIJJJIJGIGHGGGIIIIIGDDGEHCEI6BGIIJGFHDFFGHJJJHGECFECD@BDFEECECCCCDBBAC@CCDD@@CD
@7OO
CTGCGGTCTTGTAGGTGCAGTGGCTGGCGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
@B@FFFDDFFHHHJGHHIJJJIIGHIIIJGGGEGFFDGIIGIAGEHHG?BDFFDCCAABDB?(>>ACCCCDCDCABDCDDCCDDDC@CA:?B<?CBAB9<#
@7OP
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
@BBFFDFFFHHFHHIJHIJJIHJIJHIIJIGIJIGJJJJIJIJJDIIGJIJJIJIIIJFI>EFEDBB;@CEECEDDCEDDDCCCCDCDDDDDDDCDDDBD#
@7OQ
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
@CCFFEFFHGHHHJJJJJJFIGHHGHJJIIIIIIGJGIHIJJJJIJJJJIIJJGGJHIGHFHHFFFFF@ACDED;CCACDDDDDDDDDD<>CDDDDCDD
@7OR
TCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCN
+
CCCFFFFFHHGHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJIIHHIJIIGGHIIIJJHHIJJJJEIHHHHFFFEEDEEEEDDDCDDDDDDCDCDDACC#
@7OS
CGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCA
+
CCCFFFFFHHHHHJJJJJJJJJJIJDHIHHFIDGIJJIGIIJIIJJJJJJJFGIIJIJGHFEFFE;@CEDDEDCDD@BDDCDDDDDDDDDDDD?AB@BD
@7OT
GGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATN
+
B@?DFFFFHHGGGIJJJIGJJJIJIJJJJIJJGGIGIE9BFHGGEHJJJIJIIJHFFFFEEDEACDDDDDDDDDDDDDCDDDDDBDDDDDDDDDDDDDDE#
@7OU
AGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCN
+
@CCFFFFDHHHHHJJJJJIFHGHGJJJIJJJJJJJJJJJJIJJJJIIJIIIJJJJIJJJJIIHHHHFDDDDBDDDDDDDEDDDDDDDDDCDEEEEDDEED#
@7OV
GTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTN
+
@@@DDADD?FBHFHIHIGG@DHH@EBDFHBBHII>GHIIIIEG;BFEFHGI>G@FHIIIE;BHH9BCCECC;>AA??;@B?<@>AB@CCCCCACC>>CAA#
@7OW
CCTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGTGGCTCC
+
@CCFFFFFHHGHHJJJIJCJGIHIJJJJJIHIJJIJJJIJJJJJJJIJJJIJJIHHIHJJJJJJJJIJGHHHHFFFFFFEDEDEDDDEDDDA@DDDDD
@7OX
AAAAAGTGCCTTGAATGTAATTTGCGCAGAGCGCAGGCCTACCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTN
+
CCCFFFDFHHHHHIIEG<ICIIHGE?CFAFBBCFDHEHEABHADCFG8=@@@@@=DHI>=??;=AEBD?AC>AEE@C@@>;@>;>:><2<BDD>BDB13@#
@7OY
CTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTAT
+
;?@DDDA6?69?ACC@CCC@8>CCDCCCBA>?@<?BB?BBCCCCAC@C@CA@C>C>A>CCBBB;>?348ACCCC4>C83>+:A4:AC:A@3?<@B3::
@7OZ
GCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGN
+
;<?DDB;22=<?CE<E@;3+<F;FD@?:8CD>D:::?<???)??@9::83((399(++:B::3:>:2>AA?>8;82++:>AA:A44>3+4+4:>:+(()&#
@7P0
GCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTCGATAATCA
+
:+=AA=DBD<C<:CEBEBFAF?:C:C,,2A<2A?+1?C<?:8@?:DE99009*?9?*BB4=8=BD7=;CCA4.7=CA=6).7?A3=5@;>
@7P1
CTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGN
+
@@@DDDDD?BFBF@<EA??+<AEGD?FEEDBE>CGGCD6?FAECEHEFA7:FGFB8?/>?8?CCA@C:>;>9?29-&5<<:<?>CC@>>A::>:>C@@@>#
@7P2
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCN
+
CCCFFFFFHHHHHIJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFFEEDD?BDBDDDDDDDDDDDDDDDDDDDDDDDD#
@7P3
TGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGN
+
CCCFFFFFGHFFHIJIHIJIHGHIGIIJJJJGHIJJJIJJJIIIJFHIJIJIJIJJGGIIJFHIJJGJJJIJJIHHGGHFFFFFFEDEEDD;?BBCDDDD#
@7P4
CAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTCTGTAGAGCACACTTTTCTTCTA
+
==@BDDDD?=AA?G??F<@?<CDIIIIEIG?AHA9CHFEHEHE?:FB?999BBBBDHIEDD@998B=CC=F@CCC@CEA7CGIHHHE;;;;;?>;A66A
@7P5
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGN
+
@@@DDDDBFCCA<AF;?FHIGH;CG:D6FHGGHIGIIIGIAFHGIDCGHGEGII>EEGHA>=C>BDD?<?=5@CCCCBBBCCCC>CCCC:>@CC:4>AA@#
@7P6
GTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGN
+
CBCFFFFFHHHHHJJJJJJHIIJJJFHHIJJIJJJJJJJIJJJJJJJJIJJIJJJJJJJJJJJJJJIIJJJJIHHHFHHHFFFFFFDEEEEEEDCDDFDD#
@7P7
TGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCN
+
BC@FFFFFHHHHHJJJIIIJJJJIIJJJJJJJJJJIHIIJJEHIJCIIJFGHIJJJJJJIIJJIJJ@HIIHIIIIJJGIJHFHHHFFFEFFEEEEDEDDD#
@7P8
GGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATCCTCTTCCTCTGCTTCCTTTTTCTTTTTCTCN
+
?<@FADDEFDHBFGGGEFHHHGCEGIEG?E???C>DGHDDDED?099?9EEH@=E=@HE)5CA;=;C=C=>CHE;;BD@CA@CCCDDDCCCAACCCCA@@#
@7P9
GGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGN
+
@CCFFFBDHHHGHJJJJJJJJJJJIJJJJGIJJJJDGFHHIGIHIJHIIIJJIGEEEHGHFEFEFDCE;CEDD?@BDDDDBD@D@BCD?ACD4>8?BDDD#
@7PA
GTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGN
+
CCCFFFFFHHHHHJJJJIJJIJHIJJJJJJJJJJHHJJJJJJJIJJJJIJJIHIJIIIJGIJJJJJIJIJJJJJJJIIJGJEHIIJJJJJHGHHGFFFFF#
@7PB
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
@@CDDDFFFHHGHHIIIJIIGIJGIJIIIJJJJIJJIJJIJCGEIGGIIIIJIJIBHGIGHGIGIHFHGGHHFFFDFCEEEEDD>ACCBBDABBD59@5<#
@7PC
GTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGC
+
@B@FFFFFGHHHHJJJJJJ?EHGHJCHHGIIIJJGHIJJIIIIIIJGIGDECHDFEGIJJIGHGCDGEGIICHH3=7?@BEDDD??@DDDDCEDCCDCD
@7PD
GTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACTCTAATTCCTGTTTATTTTTACTGTCTTCTAAATCATCTTN
+
???DDD;A=D??:2<C+<ACC?<AA:AAFF@BA<<??E::11??1*?:?B*?BDEDI?99???D<?BD@<B=B<8===@;67=@)...=CDDDDDAA;7;#
@7PE
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATN
+
CCCFFFFFHHHHHJJJIIJIIIFHIGIIIIIIHIIJJJJJJJIGGIGIIJIJJHHGGEFFFDACCCEECBDDDDEDECDDDDDDDCDDDDBCCDBDDDCC#
@7PF
GTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGAAGGAGGTGCAGTGACN
+
C@CFFFFFHHHHHIIIIGHIJJGIHJCHIIJIJJJJJIJJJJJJJJJJHIIIJJJEHGIIGIIGIJIJJIHGHGHFFFFD?CDDDCBD?BD8<CDCAACD#
@7PG
AGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCN
+
CCCFFFFFHHHHFIJJIIJJAFHIIJJJJJJDHHIJHJJJJJJJJJJJJJJJIGHIJJJJHHHHDFFFFFEDDDDDDDDDDFDEEEDDDDDDDDDEDDDE#
@7PH
CTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAA
+
CCCFFFFFHFFHHJIJIJJJJJIIIHFHIJJJGIIJGHIJJGIIJIIJIIJJJJIJJJJJJIJIIIIHHHHHFFFCCEEECDDDDDCCDDBDD
@7PI
CTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAAT
+
@C@DFDE>CFBHGICEBEAGEEHICDBEEG<<BFHEGGIEGIGDDHI@FAGHJJJIIE7@FGGHDDCCAECEDDFE@ACE>ACEDCCDDCADACC@;>B
@7PJ
CGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
B@@DFFDDHHHGGJJJJJJIHJGGIIJFHIJIIIJJGIIIJJJJJGIGEHGIJIJGHGHGFHHFDEFFECEEDDDDDDDDDDCCDDEDEDCDDDDDCCDD#
@7PK
GTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGGGGGCTTGTTTCCATCCTGCGGTCTTN
+
CCCFFFFDFADHFEHEEHIIGHIGEEHIBEGIFBHIIIFGGGGGEI?GADF8BCFH@FHE@CCHDEHA?CCEEF);BCDDDBDCCDCEECBDDDBB999@#
@7PL
ATTTGGAAGCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJJIJJJJIJJJJJJJJJIJJJJIIJJJIJJJJJJHHHHHHFFFFFFDDEEEEEDDDDD#
@7PM
CATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTN
+
@?@7DDDDFF31<11<AE+A:F>HH>?4?E:***:1C6?F67DD@'-5AEEE>?B@.7(;@CB=?@>B:;=;=9A@AAB?>A@AA>:>@3>ABB4:>:&(#
@7PN
CTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCCTTCTGTTGGTCACACATTN
+
=??ADDBDFAD?CBGBHGHHGCHEFFHGE?FEBFHH@DDFAB?BBB<?D>BBF@GGG=BB@A@FEGGEECCHEEEEE>3>CC>C;C@;AC25>@A>>?CC#
@7PO
GGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCN
+
@BCFDDFFHGHHHJJJJJJJJJIGIJJIIJIJJJJJGIJJJJIJJJJJJIJJIJJIIIHHHFFFFFFEEEEEEDDDDDDBDDEDEDDDDDDEEDEDDDDD#
@7PP
TGCTTATACTAGAAATTCCTCAGTACTTAAATTTTAAAAGAATAAAACAAATGAGTTGTGGTTAAAATTACAACAGATTCCACTCTAACAGCAATGTCTCN
+
?@@FFFFFHFHDHHIFGHIEHIGIIIJJJIIIJJIJJJJJJIIGHIGIIJIIHJJHIC@DGHIIIJIJJGIJIJIJIJHHDHFHFFFFFFEEEECCCDEC#
@7PQ
CAGCAATGTCTCTAGGTACAGAAGGCATAACACTATGCCACTCACCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTC
+
11?;::B;4A?,<?CFCCD>@>GFFC>>FABEAF@BE*9?9<BGFG@GB@FGB8?FEG8C=C8;A5;@CE>=3A?C>?7??BB3;;(6.5@5;A@>@5:
@7PR
CTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGAAGTTCAGAGATCTCCTTTTCTAACTCTTCACAACGTATTN
+
C@@FFFFFHHHHHJGIIIGGIGIJIJJJJJJJJJJHGIEGIIJJIIJJJJJJIIIJGIIIIIJCGGIIAEDGGHIHGFHHHFFFEFFECCECEEDDBBDD#
@7PS
TCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATN
+
CCCFFFFFHFHHHJJJJJJJJJJHIJJJJJJJJJJJJJHJJJJJJ<FGIJJJJJJJHHHFFDDBDDDDCDDDDD?BBDEEDDDEDDDDDDDDDDDDDDDE#
@7PT
GTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTN
+
C@CFFFFFHHHHHEHGGJJHIIJJJJJJIGGIIIJGGGHFHIJJJJFHIIIJJJJJJ=EHHHHFFDEDCEDDDDDCDDCCDDDDDCDDDDDDDDCDDEDD#
@7PU
CTCGAATTTGTGGACTTTGATCATTAGAGTGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTTCTGTACCACTTTTAGC
+
@@CFDFFFGHFHHGGIJJJHDGIJJJJIIFHHHIIIIIJJJJJJIJJJHIIIJJJIJJJJJDHHEHHFFFFEEEEEEEDDDDCDAADDDDCDDDDDDC
@7PV
CCGGTTCTCTCCTAGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
BCCFDDFFHHGHHJIJJJJIJJJJJJIJJJJJJIGIGICHIJJJIIJJJJJJJJJIGIHIJJHHADDDDDCDCCDDDDDDDDDDDDDDDDDDDDDDDDDD#
@7PW
CTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCN
+
CCCFFFFFHHHHHIIIJJIJJJJJJJJJJJIIIIJJJIJJJJJJJJJJJJJJJJJJHHEFFFDDDDD>BBDDDCDDDDDDDD8?BDEDDDDDDDDDDDDD#
@7PX
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
CCCFFFDDHHGHHJJGGHJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJGHEHEFCEEEFFEEDEEEDDDDDDDDDDDDDDDDDDDD3<#
@7PY
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@@DDDDDF?FBHB?B@EFEGCGH><?@DGIGGGIF>:DDFH@GBCHGGIIIIIDHFDEEBDC@<CCC@CC>A@CCCCDDEC@CCCC39ABC>?C@BB
@7PZ
TGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTGTGGATGA
+
@@@DFFFFGHHHHJJIIJJIIJJJJIIJJJJJJJIJJJJIJJIIJIIFFHJJIJJJJJJJJIIJGGIJJJHHFFFFFDEEDEEDDDDDDDDDCCDDDDD
@7Q0
GCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGA
+
CCCFFFFFHHFHHJJJJJJJIJJJJIJIJJJJIJJJJJJJJJJJJJJJIIIJGIJJGHIJJJ@FHIJJJJJHGHEFFFFFFEDDDDDDDDDDBDDDDD
@7Q1
GTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGGATGACTTGGTTTTCTGTTN
+
@CCFFFFFHHHHHJJJJJJJJJJJJIJGFIJIJJJIIIIIGIJJIIJGJHJIIJGIJJJJJJJIJIGHHGGFFFFFCEEEE(;ABCDDDDDDDDDCDDED#
@7Q2
CCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGC
+
CCCFFFFFHHHHHJHIJHIJJJJJJJJJJGHIJJJJJJJJJJIJIJJJJJJJJJJJJJJHIJJJJJJJJJJJJJHHHHHFFFFFFEEDD>@DBDDDDDD
@7Q3
CCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTN
+
CCCFFFDFHHHHGJJCFHIJJJJJJIJJJIIJJJJHHHHDFFDDDDEEDDDDDDDDDDDDEDDDDDACCCDDDDDDDDDDDDDCDDDDDDDDDADDDDDB#
@7Q4
ATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTAATATTTGAATATGACCTTAAAGCATTCTCCATTTCTCCCTTATGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJIJJJJIJJJIJIJJJIJJIJJJGHHHHHHFFFF#
@7Q5
CTTTGAAATTTCCAAAATTAATTGATTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACC
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJIJJJJJJJJJJHIJJJIIJJJJJJJJJJJJJHHHHHGHHFFFFFF
@7Q6
GTCCAGGGAGCTGGAGTTGCGGCTGCCTCCACTGCCCAGGTAGCCAGGCCCCACTTTGCGGCTCTCGCGGAGGAAGCCCCGCAGGGAGCCGTATTTGGCGN
+
@@@FDFFFFFHHFGII@FEHEGGGIGIGHIGIJAGDFFCEGGIIIIF=EHEHEEDFCEECDDDDCD=<?@55>@BBBADDB@@BB@D<@BB59ACDCACB#
@7Q7
AATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAG
+
@@@FFFFFAHFFHIIJIIIIGGGGIJJIIEDDGIJGIIGCGHJGHGIIEHHFHHHHFFFFDCDE@AAC>@>>>C
@7Q8
CTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGG
+
@@@FDFFFFHFHHED8<CDHGIJGH@HIJHBE?FB@GHIGAGIG@DHG@;ACA;CDEEEACD???ABB:@DBC?>ACDDD@BD>BCC>:>:+>@AC@?
@7Q9
CTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTN
+
CCCFFFFFHHHHHJJIIIGGJJIIJJIHIJJJJJJICGIIIIJJJJJJIIIIJJJGIIJJJGIIFGIIIEHJIIIHFEECEHHFFFFFFEEEDDDCDDDD#
@7QA
AGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCAAGAGGTAAGCAAAGTTGGAGAGTTCCTCATCCTCTTCCTCTGCTTCCTTTTTCTTTTTCTN
+
@@@FFFFFGFHHHIJJJGBHDHGIGIEGHIGIIJGIIGGHIJJJDIIIIIIGEHHIIIIGIG@ECEEHCHEFFCDDBCA>CCC@CCDDDDDDACCCCDDD#
@7QB
CTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGG
+
C@@FFFFFHGHFDHACGEAEGIIJJEHIHEGGGHEFGEEFHIICGGHEGGHDHEDEEHABBDDDDDDEAAC?CACCCDDDDDDDDDDCCACCDD::@CD
@7QC
CTCTGCTTCAAGTTGTGCAAATTTTTCTTGAAGATCATTCTCTTTTTCCTTCATCTGTTTTTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTN
+
CCCFFFFFHHHHHIJHIJJJJJJJJJJJJJHIJIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJGIHIJJJIIJHGHHGHHEFFFFFEDEE#
@7QD
GGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGN
+
CCCFFFFFHHHHHHIJJJJJJJJJJJJJIJJJJJJJJJJJJJJBGIIIJJJJJJJJJJJJJJIJGHJJJJHHHHFD=BBDEDDDDDDDEDDDDDDDDDDD#
@7QE
AACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJGHIJGGIJ;FHIHIIJJHH?EEFFEFEEEEDDDDDDDDDDD=@BDCDDDDDDACD#
@7QF
GCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCN
+
@@CFFFFFHHHGGHIIIIJJJJIHGIIGIGIIJIIIIIIIJIJIGHJJGGFHGGHJIIJJJGGIJHFHGHFF<ADDDCCDDCCCDDACCBBBBCA><C?B#
@7QG
CTTCCATGAAGGCCTCTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCCTCCCTTTCTATAGTAGCTCGCCCTGTAGATGTCTCGGGCCATCCCGA
+
CCCFFFFFHHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFFFFEEDDDDDDDDDEEDDDEDDDDDDDDDDDDD
@7QH
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGGGGTCTCTCN
+
?@@DDFDDFGHFDGHA<CDEGBFHBBCCFF?@0@GFGEFIIIIEIIIGIIGGGHEC=B?=BBCCACCECCCBB>5@59@A@CA<<?BBC3<(59)0<>>:#
@7QI
CTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCC
+
C@CFFFFFHHHHHIIIIJJIGGGGHIJJJGHIIJJJIJJIIJIJJGIIIIBFHIJJJIGHIGGIJIJJGCFGFGHGHGEFHEEHEFFFF@CEEEACCD
@7QJ
GTTTTTCTCTTTTTTTTCTGCTTCTTGGAAGGACTCTGCCCATCCGACTGAGCTTTTCTTTGTCGAAACTGGGCAAGCTTGGCTTTGCCGGCCTCCAGCTN
+
@@@FFF>DDHHHHIJJIFHHBHGGEIJICDBHGHEE@GCFFDG3=AHIGIJFFEHFECDDD;@@C?C?BAAC@?CDDB>AC@CCBDDDCBBDBBBAD>>>#
@7QK
TTCAAAGCTTTCATTTATGACTCCACTGTTGTTTGCTTCATCTCTGGACTTATAAATGCTATTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTG
+
CCCFFFFFHHHHGJJJJJJIFIJJJJJJHIJJIJJJJJJJJJIJJJJIJJJJJJJJJJIJJJJJJJJIJJJJJJJJHHHHHHHFFFFFFEEEDD?CDDD
@7QL
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGACCTCATTTTCCTCTATAAGAATTTCTATTTCTTTTTCCCACACAGAG
+
8@@DDFFAHBHFHAHEHBEHIBCDFH<E:A@HAF<?A?G>EHIII?FD*8B;?9?FBDHIHII@CGI@)//==CGGGIE>DHGEHEHE;@55?266
@7QM
GTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTGCCGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJHHHHHHFFFFFFEEEEEEEEEEDDDDD#
@7QN
CCAGGGCACTGCTAAAGGCTCCTTCCCTTGAGGAAGCACTCCACGACCCCCTGTTTGTTGTCCTTTCTGCAATCCCAGGACTTGCTTTTCTAACCCTTGTN
+
@@@D=:DDHFHFFIIIIIIIIIIHIIIIIIFIIIIIIIIIIIIIFHGGHIIBHEGGHHEHBEEEEECCCCFCCCCCCCBBBCACCACCCCCEECBBBCCC#
@7QO
ATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTN
+
CCCFFFFFHHHHHIJIJJJJJJJJJJIJJHHJJJIICFHEIJJIJGGIJJGIIIJJJIIIJJJJJJJIIJIIJJIJJIIJJJIJIJJJIHGHHHHHFFFF#
@7QP
CGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIHHHFFFDEFFEDDEDDDDDDDDDDDDDDDDDDDDDDD
@7QQ
TGGTGACTGTAGCAGTGGCGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAG
+
<?@DDDBDDFBBBFHHGI+@@?C7FDBDHGEG?B?FG>?DCEGHFEFFGD;@@EG76?E?D?6;BC@CCAAB@@B>59ACCC4<+9>
@7QR
GGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGN
+
CCCFFFFFHHHGHJJJJGHIJJJJJJJJJJJJJJJJJJJJHFHHHFFFFFFFEEEEEDDDDDDDDDDDDDDDDDBDDDDDDDDDDD@CDBDDDDDDDDDD#
@7QS
GCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGN
+
CCCFFFFFFHHHHJJJJJJJJJJIJJGGIIHIJIJJJHIHHHIJJEIIIJIJIJIIJIFHIGHGEHGIJHHHHFFFFEEEEDDDCDDCDDDDCEDDDCCD#
@7QT
GTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGGGGTAACTAGTGN
+
@@?AAAD:=80+A:<+C::<C<F<9F3:)11):9;0:*99?9D<9F@?*.BF<=F)/883)...7CE=;-..77@;6(.(..5@=@B'0<B))>4:@>(+#
@7QU
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTN
+
BB@DDFFFGGHFHGHIGHGGGIJIJIII:EGGDGGH?BDC@FHECHI7C@HIGHIGEEEEEHFDEDECD>B?<CDDDDDD@CDDDDDDDDDDDCCDCDDD#
@7QV
CTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGN
+
?@<D;BDBFFFFF@FBFGI9?C3A<2C22<C<@GF<CFFIF6@80/9D?9D>-5.@;/4'9;=9(>(::>;5>A<?B3))&8<:?A@44:>4@B>::@B>#
@7QW
GCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCN
+
@@@FFFFFHCBFDHIHGGEDHEHIIJIFHGGFGFHIHHHIIDFEGHIDEII@FACHH=CCDCHEEHEB@DEC;CDACCDDDCDDCCEEDDDDDCDCCCDD#
@7QX
CGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCATGGAGGATGN
+
CCCFFFDFHHHHHJJFHIJJJAFHIIJJJJJHFDDDDDDD@DD?CCDDCDEEDDDDEDDDDDDDDDDDDDDDDDDDDDDDDD@CCCDDDDDDDDDDD@DD#
@7QY
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@CBFFFFFHHHHHJJJJIIJHIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFDDDDDDDDDCDACDEEDEEDDDDDDDD
@7QZ
ATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGGGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCN
+
???DDADAB?<CDDEA1<A?FDEA39<C<C?EE>B0CDDAA;=BCD<@)=A</98;>;;;(;9?>A>:>>>::>A:4<8>:>>>:(4:>:(4::4>:>4:#
@7R0
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
CCCFFFFFFHHHHJJJJJJIJJJJJFHIJHJJJJJJHIJJIJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDEDDDDDDDDDDDDEDDDDDDDDDD#
@7R1
CAAATCAGAATTCCAAAAGACCATACATCAGATTGAGTAGTGAAGATTCCATCCATCAAACTTTCTGGAGCCATCCACCGAACTGGGAGCAGGCCTTCCCN
+
BC@DFFFFHHHGHJGIIGIJJIIIGIIJJIJEGIJJJFHIHHIIIEIIJJIIJIEIGGICHIJJGHIJJIGIJIIJIJHHDFDDEED?@BBAABDCDDDD#
@7R2
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
CCCFFFFFFHGGGJJJJJJIIJJJJIIJJJJJJJJIHJJJJJJJGGIIJJJJJDFGIGHHHFHHCFFFFDDDDDDCDDDDDDDDDDDDDDDDDDDDDDCD#
@7R3
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
CCCFFFDFHHHHHFGIJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDEDDDDDDDDDDDDDDDDDDDDDC#
@7R4
GTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGT
+
@@@DDFDEHHHHHIIIGI+CGFHGIHGCHGIEHIIIIIGIFGDHGIIGEHI:BBBBCCEECCEDCCCCCCCCCCCCBBBAACCCCBCCCCDEC:>ACC>
@7R5
TGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJHIJJJJJJIJIIIIJJJDGIJHHIIJJJHIJIHHFFFFDEEEEDDDDDDDDDDDDDDDDDDDDDDDDDEDDDD#
@7R6
AGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCACAGCCAAAACAACTTN
+
1?:BBADDD?D:@F@<BFGB?FCBA@?DGCD>D9D>*???FHFH<6D:@=4=B>F@FE@CGGI;)@=@ECECAAB(,66;;CCCAC@;???<CB@BB<CC#
@7R7
CCAAAGCCGCCTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGC
+
@CCFDFFFHGGHGEFHHCHIIHGGGGIGIFIIIGEH@?GHGGECHHHI?BDHIIGIIGGGIEEHIIIFHFFCACC@@CCCCCCACCC5@ADD:@@@C
@7R8
TGCTCTCCTGCCGGGGGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGN
+
CCCFFFFFHHFHHIJJJIGJJHIIGIIJGJGH=ADDDEEDDDBDDDDDBDBDDB?B<CCDEDCEDDDDDDDDDDDBBCDDDDDDDCDDD<>@BCCCDDDD#
@7R9
GCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGN
+
@@@BBDEDACFHF@GHGGGEHEGEGIIIEHCHIDEHGGIGGIIIGDDHCHIIBDGGEGGICADGHIIGHFFEEF?=.9@9?B3<CCCCCECACC34>4<B#
@7RA
TTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGAAGCTCTTCATTAAGTGCTTTAAGTTTACTTTTATACN
+
CCCFFFFFHHHHGJIJJJJJIJEJJJJJIIJJJJIIIJIJJIIIJGIIJIJJJJJJJJJJJIJJJJJJJJIIJIJJJJCHIJJJGHHHHHHHHFFFFFFF#
@7RB
CCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJGIJJJJJJJJJJJJIJHIJJEHFHGHGHHFFFFEEEDDDDBB
@7RC
GTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCA
+
CCCFFFFFHGHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJHHHHHHFFFFFFEEEEEEDDADDDDDDDDDDDDDDDDDD
@7RD
TGATAATCTTCTAATAAGTGGTCTTGTTCTTCAAGCTGCTGTTGATGAGTGAGGATCTGTTGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATG
+
CCCFFFFFHHHHHJJIJJJHIGIJJJJJJJJJJJJJJJJJJJJJJJIJJGIIJJIJJJJJJJJJJJJJJJJJJJIJIJIHHHHHHFFFFFFEEEEEED
@7RE
CCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGN
+
@CCDFDBDFHHHHJJIJIGBHCHIIGEGIJIIJGHIJJJJIIIHGHJIHHHFFFDFEDCDDBBDDDDDDDDDDDDDDCBDDDDDDBBBD>@CC@CDABD>#
@7RF
GTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGT
+
C@CFFFFFHGHHHIIIJI<FGGHIJDHHIIGIJIJJJIIFHGIIJIJIIJJEBBDFDCEDCECDCDDDD@BCDDDDDDDDDDDDDDDDC>@CC+:@CCD
@7RG
ATTCCATCTCACTGCTCAGCCAAACTCCTGGGCTGAGACAGACATCGTCCCTCTCCCCAGCTGCTCTAGGGGAAGGATTCTGATCATAACTCTGAGCCATN
+
CCCFFFFFHFFHHJJFIIIIJJJJJJJJIIIJJJJIJIJJJIIIJJJHIJJHIJJJJJJGIIJJJHHHHHFFFDDDDDDDDEEDDEDDDDDDDDDDDDDD#
@7RH
GCTTTTCAAGGGAACAGATTCAGAGAGCTAGACAGACAATAGCTGAACAAGAAAGTAAACTTAATGAAGCACATAAGTCCCTTAGTACAGTGGAAGATTTN
+
C@CFFFFFFHHGGJJJJJIJJJJJJJIIJJJIJJIGIJJJJJJJJJJIJJJIJJJFHIIJJJIIJIIJJIJJIGGHHHHFFFFFFEEDEECCDDDDDCDD#
@7RI
ACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCC
+
CC@FFFFFHHHHHJJJJIFHGHIIJJHIJJJJJDHIGHGJJIIIIGJIFHEGHHHHHHFFFDFEECEDEDEEEDDDCCDDDDCDDDDDDDBCCDDDDD
@7RJ
GTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTN
+
?=?DDFDDHHFDFHIJGHGHGHFIGEFGHJGCHHIHEGCFHDFEGIJG:BGGIJIGIJJF7;@FFCGHI=DHGIIFEABEFCEECCEA>B>>BBD>:@>C#
@7RK
CCGTTGGTCCCCTCCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGN
+
@@@???8DFHHFBGGIIGIHGIIIIIIIGGEGIHG>CGBEGGHGIHG65;?BDD;@C@C@A?@BBCCCCCCC@A@C>?BCCCCCCBBBBBBCCCCB9AB5#
@7RL
GTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTN
+
=@<D:BBDF?DF?><<A4:AE<CF>C:3C39CHGCB@BFEGEEFIFDGFC)???<?B@F<<F<DAFCBCBBFCAFIGIA;D>;?E7?>E3);7;@A@AAA#
@7RM
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
@@?DDDDDFHHDFIIGD8:AFGHIIIHGGG;FGGH6D@B@82C1@FGGHED;EEA44?>ACC@>>A;9--;;/2;9<CC>3:A?C@8:@@C::?8@ACC
@7RN
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJFGIIJJJIJIJFGIGHEHEEFBECDBDEDEEEEDCCCDDDD?BBD#
@7RO
ACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTT
+
@@@DDDD?FHFADHEGFEC=:<?CHGCGEAEGGEEGEG>@HIGHIIGEGHGIGHEEGHIIIGIIGIIGIIEEGHGEEGIGIGECHHFEEEEBEBDCCDC
@7RP
GCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGN
+
CCCFFFFFHHHHGJEGIIJIJIIIJJJJGHIJJJJJJJJJJJJJJJIIGHGGIJJIJGIHIJIEHIJIIJJJIJJGHGGIFFHEHFFCCCEEDDDCDDDD#
@7RQ
GCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGN
+
CCCFFFFFHHHHHJJJEHIJIJHIJJJJJJJJJJJJHHHHFFDDDDDEEDDDDDDDDDDDCEDDDDDCCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@7RR
CTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATN
+
CCCFFFFFAFHHHJIIJJJJJIJIJJJIJIJJJJJJJJIHIJGGJJJJJJJIIEGGJJJJJJJ@EHHIJJHGHFFDEEEDEEDEEEDDEEDDDEDDDDDD#
@7RS
CTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGN
+
CCCFFFFFHHFHHJJJFGHJJHFHIJJIJJGHIIDGHIJIJJIIJJJJGEHGEEEHEHEHHGEDDFFDECDECDDDCDDCDDDB@CCDDDCCDDCDDBBB#
@7RT
CCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGN
+
CCCFFFFFHHCCDGHIJJGIEGFGHJJHIIGHIIIECGGHJGHHGGGIIIEFGCHIHGCFHGGGIIGEHEEHBAEACDB>?AC3;2=C5;>A@;5>@>C;#
@7RU
CTGTCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTN
+
BCCDFFFFHHHFHIJJJGIJIHJJJJJJJJJIEGIIIJJIJJJIJJJIJJJJJJJJJJJJJIIJJJJJJJIJJIIHHHHHFFFFFFEEDEDD;@BBCDDC#
@7RV
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
@@@FDDFDHHHHHIIGAFFHFGIJJIGGIJGIJIIIIJJIIJIGGIGGEHGGEGGGIIGIEEBEDF?@@C@CEAECDDCCDDCCCDDDCDCAC@CCBDDD#
@7RW
GAGAGGCAAATGCGTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTN
+
CCCFFFFFHHHGHIHIJIJJJJJJJJJJJIGIJJIJJJJIIJJJJJIJIJJJIJJJIIECHGIJJJIJJIIIJJHHHFHHHFFFFFFFEEEEEDEDDDDD#
@7RX
CATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTGTGTTGACAGGTTCTATGGTTTCN
+
@B@FFFFFHHHHHJJIJJJJIIGIJJJEFIIIJJJIJIJJJIIIIIHHIJGIJJGIIJGIIJJJHHHHHGFFFFFFF;6>@CDCCDDDCDDDDEDD>CDD#
@7RY
GGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAA
+
CCCFFFFFGDDHHJGHHIIIJIIIJJGIJJJIGHIJDGIJIJIJJIIIIIJJJJJHHHGHFFFFDDDDDDDBDDBDDBDCDDADCCDDDDDDDBDDDDD
@7RZ
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
CCCFFFFFHGHHHJIJJJJJJJJGHIJGIJJCGHIHIJJIJJBGIJJJJJJJJJJJJJJJJHHHEEFFEEEDEEDCDDDDDDDDDDDDDDDCEDEEEDDD#
@7S0
CTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTCGGTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGN
+
CCCFFFFDHHHHHJJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJFHIJJJJJJJJJJIJJJHHHFFFDDDDDDCDDDDDDDDDDCDDDDDDDDDDDDD#
@7S1
CTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATN
+
CCCFFFFFHGHHHJJJIJJJJJJJJJIJJJJJJJJJJIJJJJJJJGGHJJJJJJJJJJIJIJJJJJJJJJJJJJJJJHHHHHHFFFFFFEEDDDDDDDDD#
@7S2
GGTTGATTAAATTTGCTCATCAGATGTACCTCCTTCAGGAATTCAATCTTCTCCTGGTCTGTGGAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTN
+
B@BDFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJJJHIGIIJJIJJIIJJIGIIIJIGGIJIJJJJJJJIJJJIJJJJJHGHHHGHFFFFFFEEEECEEE#
@7S3
CTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATN
+
C@@FFDFFFHHHGJGHJGGGHIHGCFHGCFIGIIJJIIIIEGIHIJIJJJJIGGDFFFGGDDDFGHE@F==FBFC4CHGACDGHI>EHHHA@B;CE>C>C#
@7S4
CCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATN
+
CCCFFFBDHHHHHJJJJEHIGIIJJIJJJJJJJJJIJJJJJJJJJJJJJJJJJJIIIHHHHHHFFFFEEEEEEEEDDDDDDDDDDDDDDCDDDDDDDDDD#
@7S5
TTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATGATTCCTTTGTTACAGATGGTAAGTGATCCN
+
CCCFFFFFHHHHHIGIJJJJJHJJJJJJJJIJJIIJIJJJJJJJIIJJJIJIIGIJJIJJIJJJJJIIJJJJJJJJJJIJGJIIIIHGHHCHHGFFFFFF#
@7S6
GGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCN
+
CCCFFFFFHHFHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJJJIJIHJJHIJHHHHHFFFFFFFEEEEEDDDDDDDDDDEEDD#
@7S7
CTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTN
+
CC@FFFDDHHHGFHGIJJJJJJJJJIGJJIIJIIIIIJJIJJJJJJJIJJHIIIJHIJJIJIJJHIIJGGIJIIIFGIJHHHHHHFFFFFFCEECEECCD#
@7S8
TGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGN
+
@@@DDDDDDBDH?FG:EB8ABHGBGGIHIIIII<FGHGGIIIIIDIDFGEHGHGIIHBH;CAGEHIGFHFEB7;<9>AC@C39>3::>B>>>?:AC@<@B#
@7S9
ATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTN
+
CCCFFFFFGHHHHFGGIIJHHIIIJJJIJJJIJJIIIJGGJJJIJGHEIJJJIJJJJIJEHIIJJHFHFFFFFFFEEECDDBDBDDACDD:@CDDDCDDB#
@7SA
GTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGA
+
BB@FDDDFHHHHHJIJJJJFGIJJJIJJJGIJJIIJJIJIJJIIIIJJJJJJJJJJJDDBDDDDD@C>CCDDEEEDDDDDCDDABBDDBBDDDDDDDD
@7SB
CTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
???DA?B?D>FHFE;FEFFBF@CFH@CHEG>B?<9:FD;?B?6DG?DG8D<B?4===;(66=D@;;@;=>3??BBBC>CCC@CCBCCCBBBBB@CCAC
@7SC
CTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTN
+
?@;;DDD?DDF8<?@F3CA3:<AC<ECFHCHFIAA?DGBED6?@@=ACC7==C>CCD@A=7=A;3=?>;?);7.6>;;.>B;5;AA@;AB>;5@>?:@A>#
@7SD
GGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATA
+
=@@=DDD4CFB?F:AAFHEHEAEEFEHHGA<9ECFCDB>1?*::D)*00?<DHI=77@GEHEEEEGEHCH=CE;CE?CC;A>>3>;A25((,5@CCCCD
@7SE
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGGGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
<;@BDDDDHDBBFCHIII@HHCC=FGG@F@DEHEGIII)6<56@CC8A?@9?BCCCCCCCCCBCC<<>@BBBCC>>CCCCCCCCCBCCCCCCD@:@CCCC#
@7SF
CCGGAGTTCCCTGTGGAGCTGCAAGTTCTGGCTGCAGGTCCCAGCTGCTGGGGGATGGCAGAGTGTTCCCATCCCTGTGCATCCCTCTGGGGCTATCT
+
@@@=D@DDBACFDFE@G?@GEEGIGBB>FG3DDEBFABD?FF<<FGHBGCDG@FBB;CEHED;7;>@>>>ACCBBAC>@:AACC9>C<ACC@BB?CA:
@7SG
TCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJ@EFDFFFEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDD#
@7SH
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
@@@<BA::0CD8CFFBAHEHGGICFC:CF:BBCF?FG@@BGGHED?DHHGIGIGGIIGG2=EEEHFEDED@6;>C@>@=?:;-))5A>:A:?+(4+4(4
@7SI
GTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTN
+
CC@FFFFF<CFDFGGIIGHEGGIIJGIJIIIIIIIFHGIIIJJJGJJGIIIIFHHHGEDFFEFFCEEEEDDDFDDDDDDCDDDDDDDDDDDDDC:ACDDE#
@7SJ
CCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJHIJIJJJJJJIJJJJJJJJJJIIJIJIJJHHHHHFFFFFFFEEEEEEDDDDDDD
@7SK
GTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCN
+
<@@FFDAEHDHHDGGGBHJB@FHGIGHDFCFEECGDHFHI@FHIFGGHIEGEFBDCBB>>@;@@@BBDDD>BDDCD<>ACACECECCDBCCA@CDDCDB<#
@7SL
CTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGGGGCAGCTGGGCTGCGCTCCTCCTCCCGTTTTGCCTGTTGAGAGACCAGGAGAGGAGGAACCCCCTC
+
@@<DBDDDDFFCFH<E@GGGHBGFECE9CD:DGAAD@@;BF;FEIIIEEEDDECCCCC?B?BC@AA>>ACACCA<@?C@CB??B8?B?<>@A?BBBB9@
@7SM
GTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTN
+
?@CFFFFDHHFFHGDGIIIGGIGFFHIIIGGGHGIGGIIGIIEGHIEGHGCF;FHGHHGIIII;=ECEHHFFEFDCCDCEEC:>@;;=CD@>CD:@CCD@#
@7SN
CTTTTCAGTAGGGGCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGN
+
@@@FFFFDDFFF@GGIIHIIIEIJIEIIGD@BHIIIFIGGGICHGHGGHFCHDHCEH;EEHCHCEHDFFFBDEEDDD?@CDD@CDCCDCCCBDB<>B?CB#
@7SO
CACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCN
+
@@@DFFFDHHHHHFIGIIJIJJJJJIIGIJJJIJJGIJJICHIJJJGGHHHFFFDDDEDDDDDDDDDDDDD@DDDDEDDCBDDDCDCDCDDDDDD@BBDC#
@7SP
CCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGN
+
BCCFDFFFGHHHHJIIIJJJJJIJIIJJJJJJIJIJJIJJJJIJJJJJIFHIIJJHHHHGGFFFFFEEDDACDDEDDDDDDDDDDCCDDDDDDDDDDDDD#
@7SQ
ATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHHHEHHFFFFDEEEEEEEEDDEDDDDDCCDDD#
@7SR
GTCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATN
+
C@CFFFFFHHGHHIJJIJJJJJFIJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJIJJJJIJJIIJJJJJJIIJJJJJIJIIIJJGHHHHHHFFFDFEEEE#
@7SS
CTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCC
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJHHHGHHHFFFFFFEDDDDDDDDCDD
@7ST
CCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJJJJJJIJJJJJJJJJJJJJJJIJJIJIJGJJJJJJJIIJJJHHHHHFFDDEDDCDDDDDDDDDD
@7SU
TGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACN
+
?@@D=DDDFHDFHGIGFFHIII?GHCGG?DFEHGHGIGIIIIHBGGHGIIIIIIIIGGGIIIHFFFEEEBCCDCCCCBBBBBBBBCCCCCC:?C@C>CDC#
@7SV
GTCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
BBBDFFFAFHHHHIIIJIJIIJJJJGFHGHIHHJJJJJJJJGJJJJJIJJJJJJJJJJJJJIJHHHHFFFEDEEEEDDDDDDDDDDBDCDDDADACDDEE#
@7SW
TTTTCAAACTGCATGGTTTCTATCTTTTAACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCA
+
@B@FDFDDHHHHHJIIGFHGGIJIJJJJJGIJIHJJGIIJJJJJIIJJJJJHEHIJJJJJJJJIIIJIJGJGIIHIGGIIIJJGGIHHHHFHHDFFFFF
@7SX
CTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGN
+
@@@FDDFFGHFHHIIFIIJIGHIFIGHGHGIIGIJIJIIJGHIGIGIJGIIIIGGIFGGGIGHHHGHBABDDDDDBBDB<ABBDDCDDCCCCDDCDCDDD#
@7SY
CTCCGAAGGACCATGTGTCTGTTTTAGAAGTGAATATTCCTTCCATGAAGGCCTCTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCCTCCCTTTCTN
+
@@@DFFDFDDFHHIIGHGIIIGHHGJJGIIHGGIGIIGIIGIJJJIIGGFGEEHIEDEEGGHFHFFFFFFEDDE@C=CBBBDDDBC@?C?A?CBDDDDCD#
@7SZ
GCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGN
+
@B@FFFFFHHHHGJIIIJJIJIJIIIJIIJIJJJIIJJJFJBGGIJIFHD?BDDDCDDDDDCDDD<@?CDDDDDDDDDDDDDBDDDDDDCDDDDCDD?BB#
@7T0
CTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTN
+
CCCFFFFFHFHHHJJHJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJIJJJJJJIIIJJIJJJJJJHIJJJJIHJJJJHHHHHHFFFFFFDEEDEEDEE#
@7T1
TGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGN
+
@CCFFFFDHGHHGHGIJIIIJIIFHIIIJFFHDG@FGGIJJCGGGIJJJFIJHHHHHFFFFFEEEEEDDDDDDDDDDDDDDDDD@CDDDDDDDDACDDCD#
@7T2
CGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGN
+
@C@BDDFFHHDFFIBFHIFHG?FDGHIIIIGBGFG?DF@GGIFHIIIGIIIGFHGCHHIIBGIH=CHHFFFFFECEECACC5;@@:??B,58?::AB>A?#
@7T3
GTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCATATCTCCTGATGCAGTTTN
+
@B@FFFFEHHHHHJJJIJJJJJJJJJJJJJJIJJJJJJJJJJJJJJHIJJJJJJJJCHHIJIIJIJJJHHHHFFFFFFFEEEEEEDFDDDDDDDDDDDDE#
@7T4
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
CCCFFFFFGGHHGIJJJJJIIJJIJCFHGHIJJHIIJGJIJIJGIIIJJJJJGGIHHFFCFFEDDDAECDDDDDDDDDEEDDDDDDD>CCDDD??C?B
@7T5
GTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTN
+
CCCFFFFFHAFHHIJJJJJJFHIIJIJJJJJJJJJJJJJJJJFFGIJJJJJJJ@GIJJJHHHFFFFFEEEEEEEEDDDDDDDDDFDDDEEDDDDDDDDDD#
@7T6
CTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCN
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJIJJJJJJJJHHIJJJJJJIIHGIJJJIJJJJJHIGGIGHHHGHHEECCDECEDDBDDDDEFDDCCDDBBB#
@7T7
CCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGG
+
CCCFFFFFHHHHHJJJJJJJJJIHHJJJJJJIJJIJIIJJIIIJIJJIIJJIJJJJJJJJIJHIJJJJJHGHHHFFFFFFEEEEEEDDCDDDDDDEEDD
@7T8
CTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGN
+
CCCFFFFFHHHHHJHHIJJJJJIIJGHIJJJJJJJJJIJJIJJJIIJJJJJIJJJJJJJJJJJJIIJJHHHHFFFFDDEEDDDDDDDCDDDDDDDEDDDD#
@7T9
CAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCN
+
BCCFFFFDHFHHHHJJJJJJJJJJJJJJJJJIJJJJJJJJIJIIJJJJJJIJJJIJJJHHHHHFFFDFEEEECCDACDDDDDDDDDD?CDEEDDDDDDDD#
@7TA
AGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCN
+
@CCFFFFFHHCFHJJIIJJJJJJJJJJJJIJJGHIJJJJJJJJHIJJJJJJIGIJJJJJJJJJHHHHHHHFFFFFFEEEEEEEDDDDDDDDDCCDDDEDD#
@7TB
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGACN
+
CCCFFFFFHHHHHGHIIJJJHIJJJJJJJJJJJJJIIIIJHIJJJJIHJJJJJJJJJJJIJIJJJJJJJEHHFFCDDBDDEDDDDDDDDDDDDDDDDDDD#
@7TC
CTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGN
+
CCCFFFFFHHHHHJJJJJJIJJIJIJJIJJJHHIIJJJJJJJJJJJJHIJJJJJJJHHFFFFFFEEDDDDDDDDDDDDDDDDEDDDDDDBDDDDDDDDDD#
@7TD
CTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGAC
+
@@@FDDFFHFDDHIFHIIIIIIHGIGHHEFIGIJJGGGIIIJIGAFEHIJJGIGHGEIGFHIIJGIIIGHFGIDGIJJHDEHIIJFHFHADCFEBDFE
@7TE
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
CCCFFFFFHHHHHJJHIJJJHJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIIJJJJJJHGHHHFFFFFFFEEEEEDDDDDDDDDDDDCDDDDDDDD9@#
@7TF
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHHHJJJJJJJHHIJJJJJJIJJJIJJJJJJJJJJJJJIJJJJJJJJBFIHIJEHHHFFFFFFEEEEE@BD@CDDEEDDDDDDDD9@CDD
@7TG
CGCAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTN
+
@BCDFFEFHHHGFIJHJGHHGIJJJJIIJJJJIIIIIJJJGIJJJJJJJJJJIJJJIHIEIJIIG=FFGIGIIIJJJHHHHGEFFFEFFEEEE>CDEDED#
@7TH
GTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTC
+
@@@DDBBBFDHBFGGBDGFEGFEEECGGGEGAEGGHGGEEGEHGGGEEGCHHIEG>FCFEAAB@FBA@AACEEEGC>7;?AECBCDDCCCCCAC?@>B=
@7TI
AGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTN
+
CCCFFFFFHHGHDIIJJJIJJJJJJIJJJJJIIJJJIEHGGIHHIIIJJIJJJIGIIIJJJJIJIIGHHHHGGFFFFFDCEEEDDDDEDDDDDDDDDDDD#
@7TJ
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
BCCFFFDFHHHHGJJJJIHJJJJJJIJIJJJIJJJFGIJJJIJIJIJJJJIJIJJIJJHHHHHFFF9>B>CDDDDDDDDDDDDDDDDDDDDDDDDD@BBD#
@7TK
GTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCN
+
@?@FDFFDDBHFHGIIIAFDHIFHC9GHBHGGHIIGIIEDHDGAH?GIIIIDFHIGIEGHDHIFEHEAEHFEFFDDDDDDDCD>A>CCDC@DCDCDDDDD#
@7TL
CTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CCCFFFDDFHFFHIGIIIFGGGIIJJJJDDDDCDDDCC8ACCDDDEDDDB9ACDBDDBDDDDDCEDDDDDDDDDDDDCDDCDD>B@DDDDDCDCDCAC@
@7TM
AACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCAT
+
@C@FFFDDFHHHDGHIHGIGIGGEGIJEGGEHGGGEHJJJIEHIJIGIGGHCEHEFECCHHFF??CCCEBBD=@C@DDDDDCCDDDA@CCBBD@DDDDC
@7TN
ATCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTN
+
CCCFFFFFHHHHGJJJJJIJJJJJJJJJJJJJJJJJJHIJJIJJJJJJJJJJJJIJJIJJJIJJJJJJIIJJHHCHFFFFFFFDACEEDEDEEDDD<BDD#
@7TO
CTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAAAGCAACTGGC
+
@CCFFFFFHHHHHJJIJJJJJIHIIJJJJJIIIHIJJJJIJJJIJJIHHIJJJJIIJJJJJJJJJJJJGIJJJJ
@7TP
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
B@@DFFEFHHHFFCFGIFGGJJIJFGIJIIJIGFFGHIIJIIJJGIGIIGIIIHHEHHGFFFFFEECCECDDDCDDCDDDDDDC@CBBDDDDDDDDCDD>#
@7TQ
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJIIFHHJIHIJJHHIJJGIJIJJJIJIJIJIJJIGECGEHGIIIJHHHHGGHFFFDEEDCCDDDDDDEDEDDDDDDDDDDDDC
@7TR
GTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACN
+
CCCFFFFFHHHHHJGGIJJJJJJJGGHJIIIIJJJJDGIIJJJJJBGIJJJJJIJJIIJJJJJIJIJHHFFFFFEEEEEEEDDEDDDDDDDDDCEDCDED#
@7TS
GCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGN
+
CCCFFFFFHHHHHJJJIJJFHIJJJJJIFHGIJJJIJJGIJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJJGGIIJJGHHFGFFFFFFEEEEEEDDDDDD#
@7TT
GCCCCTTTTTGTGTATTATTATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAGGAAAAGCGN
+
CCCFFFFFHHHHHIJJJJJJJJJJJIJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJIJJHHHHHHHFFFFFFEEDDDDDDDDBB#
@7TU
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
C@CFFFFFHHHHHJJJJJJIJJJIJJJJJJJJJJJIJIJJIJJIJJJIIJIJJJJIJJJJJJJJIGIHHHHHFFFEEFFDDD9?DD?CDDEDCCDDDDDD#
@7TV
AATTATATCTAGTCTTTAACCACACAAGTGTTCTTTGGTTCACCTTAAAAAAAAAAGAGAGTATTTTATTCAATTTAACATATAAGCAAACATATGTTC
+
CCCFFFFFHGHHFIIJJJIJJIJJJJIHEHHHIJJJIIHIIJIIJJJJJJIJJJJHFEEED>ACEFEACDEEEDEDDEDDDDDEECDDDDADCCDDCDD
@7TW
CCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCCAGTGGCCAAGTGAGTCCCCACCAGCCATTN
+
@@@FDDFFHFHBHGHIIIIGCHIIIIEGE@GGEHHEHIGGEIIIIIEIDGIIIIGGGIEGCFHCHIGIIIGIICHEEDFB?@ACC@AEDBCBBBDDDBDD#
@7TX
TGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTN
+
<?;DD3A3D3ADDEEE>EFDEF>CEEI>928CEEDAEDIDIDEI@@ADDDD>>CDADEBA;A@@=4=@7@4@C.?5.7?@:7@DA3>>>33>5;->>???#
@7TY
CTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCAAGAGTTTTCTTTTCTTCTTCTATTATTTTTGTGTTTAATTCTTCAATGATTGTCTCN
+
@@@?DBD=AC???A::AAFAAIIHIIBHHEI?CACHBGEHGABC?C1:FFCG9?DGGIBFDBFH@FH>===FHD@.=8=@E@D@7===A?A?DE>;7...#
@7TZ
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGN
+
CCCFFDFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIHHHHHDFFDFFFEEEEEEDEDDDDDCCDDEDDDD#
@7U0
AGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFGHHHHJJJJJJJIHJJJIJJJJIJJJJIJIJJJJJJJJJJJGIIJJJJEHIEHIBEHHFFFFFFFEEED>@D?CDDEEDDDCDDDDDCDDD
@7U1
ACCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCN
+
@@@FDB?DHHHHGIGIGGFDGIGHGGIIGHIIHHIIIIIGGGHIGGIEHGFHGGAHGGIGIIIGHCHFDEAAC>CCCCCCCCBCCDDDCCCCC>CD@BA:#
@7U2
CTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTN
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIIJJJJJJJJJJJIJJIJIIJHHHHHHFFFFFFFEEEEEDDDDD#
@7U3
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHIJJJJJIJJJJJIJJJJJJIJJJJHHHHFFFFDD>BDBDD;@CDDDCFDDDDDDD@?#
@7U4
CTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGGGACACCCTCCCGGGGGN
+
CCCFFFFFGHHHHJJJJJHIJJJJJHJIIJJJIJEGHHIJJJIJJ?GGHIJJJJJJJJJJJJIJJIJEHHHGFFFFE@CEDDD0&&)(+2&++(()9>@>#
@7U5
CCTCAACAGAACCAGAAGGACTTGAGTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCTGCATCTTCCTCCTCTTCCAAGGCCATGAGTCGCTTCTGN
+
?@@DDBDDDFFHHGG@B<+<<AAHFH9AFB?::CGE>):8DFHCGG><CC=88CHAAA995;;;66;AACC@CCCC:>:>>>>89589@C>(4<@5+.(4#
@7U6
CTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTN
+
:=8?DDAD8FFFFEEB<FFFDIFF<AFFFIIFFG@CGGIBG<9B:?@7BFE@>FE@FCD;D@C;;@EEI9?B<>8;'883)<AB@AABBBDBBDEEDD@>#
@7U7
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJGIJJJJJJJJJGJJJGGJJJJJJIJJJIJJJJJIJJJJJJIJJJJ@EHDFFFFEEEEEEEDEDDDDCDDBDDDD#
@7U8
GCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGACAGCAGAGCAACTGGN
+
CCCFFFDFHHHHHJJJJJJJJJIHHIHJJJJIHIJJJJJJJJJJJJJJJJJJIJIGIIJJHIHHHHHFFFFEDEEEDDDDDDDDDDDDDDDDDDDDDDDD#
@7U9
GCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTAGCCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJGHHIJIIIJJIIJHIJHIJJJJJJGIJJJHIJJJIJJJJIJJJJJJJJEGIJHHHHHHFFFFFEDEC#
@7UA
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@<BDEFFFHGHHGEGIICADHFHHIIEGHHIIGJDH9CGGHHIIIIIEGIEGEEEFHFBCEDFDECEEDDCCCCC@CCDDDED:@ACCDCDDD<BBCD
@7UB
GAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCN
+
BCCFDFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJIFHHIJJJJJHJJJIJJJIJJHHHHHHFFFFFFFEEEEEDDDDDDDDDBDDDDDDDEDDD#
@7UC
CTCCGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
@@@DDDDDHHFAAAEEDGB?@BEHBFCAFDHB8BB?4DFH?<BFBD<FC;@7@EHGFCEC=CECEACCACA=?BBCCC?BB3;BC:>@?CC<A>CCCCBB#
@7UD
CTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJFIJIIIJ;FHIIJJJCHIJHIJJ;CHHHFFFFFD=BEDDDDDDDDDDDDDDDDDDD>
@7UE
GGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGN
+
?@@FDDFDFDHGHJGI@BC=FG>GHEIJIJJJJGIIGCFHHIJJJEHIIFFGHIIIHHHEE=A@@ED?CC@ACCDDCDCDDDCDCCDC>CCDACDC>:@A#
@7UF
CCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTN
+
CC@DFFFDFDHHFGGIEHEHGGGIIIIIAHIJJECD@FHGGHIIIGGHHHIIHGHEAHFFHFFFDBAECCCD@@CDDDDBBDBBD:ACDDDDDDDDDDDD#
@7UG
CCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGATTGATCA
+
@@@FFFFFHHHDF<CFHGIEHGDIIAHCHIIIGHGCHIIIIEGIIIIIIEDBFHGEFHGFHGGIIGHIDGHI@FHHGGGGGHGGEEGHIGHFGHGFFDF
@7UH
CTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGGACCACGCGGCCCAGCTTCTCGN
+
<8=DBBB3A2A:A4CD<AEDEFF<?9A99F?CD?6?:?@?03BBDC;A;@D@C@<</=(.5,9,,;8>A?A>>>(;5>>A>9<<80;;9;>78<A>>:4<#
@7UI
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJCHHFHJIJHIIIIJJJIJJJJJIIJJJJHHHFDECEEEEEDDDDDDDDDDDDEEFEDDDDDDDDDDDDDDDD#
@7UJ
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CCCFFFFFHHHGHJIJJIJGEFHIIIJJIIJJHJIIIIJJJIJJJJJGIIJJJJJJCGHHHIHHHHFFFFFFEEEED;@B>CCDEDDDDDDDDDDCDDD
@7UK
CGGGTTGGAAGCCTGCGTCAGGACCCTCGGGGCGTACTGGGGCACGGGGGACGGGTAGTACTGAGCCGGATGCACCTCGTAGACAGTGGGGACCACAGTGN
+
@@@DDAD<D?FA;<EB:188CACFBFGIIF<FFB=/???>6>??@;@@@BB5:@5)08>B@ABB@>?B@50;@A@398<8@?<:>@::A8&20?BB(84@#
@7UL
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
@@<BDDD?FBA+:<AFHD>GEGGEGEH@BFECFDFE<BD@DHGDCE>9BCDHCEEHG7=CDC7CEG@A=?BD>CDD@CAC@BB3;/>>5:@@,:@>C4:3#
@7UM
CCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAA
+
?@?DDDD;CF<DDA2<CGEFFDHB9:EC;GDG<8@:F49BFF=C=CA@AEA@EEF45,9566(.53>;>>;;;?B93>AA3:>@BA?@:@:@ABB<?AB
@7UN
CTTGGATGTACTCTTGCTTCTGTTCACAGTTCACAGCACAGCCTAAGATGAGCTGAAGCATCCTTCCAAGCTCTGCTGCATCAGAATGCTCCCCAATA
+
CCCFFFFEHHFFBHIIIIJGIDJIJIIIIC@FFGCEGEG@CFHIHGFFG@>DHGIJJJJJIJIIJJJIGAGHIJGGGFHFGHF@CCD?CCEEDDC@CC
@7UO
CGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCN
+
@@@DDADDDDDHH<FGFBBC<AFAFF*?1C?<*1:C@<3BDDHBDGDH?BFH?=BBBFCHCFAGG'998,55@C:5--9?B@/<2(+:ACBB@A94:@(>#
@7UP
GGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATN
+
CCCFFFFFHHHHHJIJJJJJJJIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJIGIJJJJJJJHHEFHFFFFFFEEDEECDDDEDDDCDDCEDED#
@7UQ
AGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCN
+
CCCFFFFFHHHHHJIJJJJIIJJJJJIJJJIJJJJIJJIJIIJJJJIJJJJJJJJJJIHHHHHFFFFDEEEEDDDDDDD;@D5ACDDDDDDDDDDCDDDC#
@7UR
CTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGN
+
CCCFFFFFHHHHHIJIJIJGHIJJJIJFIJJJJJJJJJJJIIJJJJJJJJJIHHHFFDFDDECDDDDDDDDDDDDABDDDDDDDDDDDDDDDDDDDDDDE#
@7US
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGN
+
CCCFFFFDFDHHHIIHIJJJIIJJIIHJIIIJJJJJJJIJJJJJJIGGIJJJJJJJAEEBDFEECACDDDDDDDDDDDDDCDDDDDDDDDDDDDCDDDCC#
@7UT
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@CCFFFFFHHHHHJJJJJIJJJJHHJJHIIJJGIGJJJJIIJJJJJIJJJJJIJJJJJJJIGHHHGGFDFEEEA6>CCCCCDDDDDDDDDDDDCDDDD
@7UU
CGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGA
+
@@@FFFFFGGGFFGIIJII<GGIIFHHIIJIJJDECHGIEHIIFDHICD=CEHEHF7);BD>ACBDEDDDDACCEDCDDDDDD?BDCDDCB8?ADDC?C
@7UV
GCTTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
@@<DDBBA88C?:2<FFFFHFEH99F?9CDFFFFCBBAG<FBFDDEBBFF>F<BF>=;;CD;AA?E>@?5@?6.5;AA;@@B=;599<BA>A>?>BBD::#
@7UW
GAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCGAGGGCGGGTCTCTCGGAGGAAGGACTTGAGGTCTCCCCCCGCCATG
+
CC@FFFFFHFHAHIIIIFHHIJJGHIEGIIJGIGHG?HIGHGIJG@FBABBCDDDBDBDD7@C@CABD>B>@B?@BDDDCDD?>ACCDDDBDBDBBDD
@7UX
CAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCC
+
@@?DBDBDH?DAHHH<EEHE@FGIHIIGHGIGBGCCGB?E9CD>FGEGD<FD?GGGIHHHGF@?DB=CFEHI@FCHGCGDEH@DCAA;?CHD@@C@A@A
@7UY
GGGTGGTGGCGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCN
+
?@@=BD@BB+<DAH@CDHIDD?CG:DF0?DDHHAGGHEGIHGEFCGG>@GHHGIEICEEHDEBD>CCC;@@>>>CCBBBBB<>B<:CA3?+3>4::CDCC#
@7UZ
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
@@@FDEFFHFHGGJJIJIIGHJIJJJJJGIDHEGIIGIJJJJGHFGIJJJJJIIJGIJIJJJGIJIGGIHHGFDD@BCEEEDDDDDDDDDCCCDDDDB2
@7V0
CGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
18?DDDADA?:<<E;:C<FDAFEA?AD+?FF)?CFEGIIBFI(8*9BBF<<=F=2@;7C@DE?A9/,;;;AB@A?;A>@AB<@:?89@A:ABDB:>>::A#
@7V1
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
CCCFFFFFHHHGHJJJJJJJJJJJJHIJJJIIJIJHIIJJJJ?GHIFFHGJJJHGIJJHHFFFFEEEEDDDDDDDDDDDDDDDDDDDDDDCDDEDDDDCD#
@7V2
GGCTGGATGGCTTCGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGN
+
@@@DFFFEBHFHHEHE<GIGDGGAGHGBFH;FEBFBBEHGHAE3=@CDBBCDC;>@A?5?;@=A>CDC:AC?BD0>BB:>>CD:>C(+<02<>BCCCCDC#
@7V3
CCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCN
+
@C@FFFFFHHGHAGFHIGFIHIJIIGIJGEHIJJEGEHHIIJJEIAHII?DHHIIJIIJJJJICEHGHGGE<EEDFEEEEEEEABDCCCCDDDCCCDED>#
@7V4
GGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCC
+
CC@DFFEDHHHHGGGIGGGHDEGHGHGHIJCHHGHIGIJJJJJJGHIIGIGFGIJI3@GAGI<C>EFF@DFFEA;@E>?B@@CCDDDDDCCCDB<>CCC
@7V5
GATTACATCCGGGTCCTGGGTGCAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCN
+
CCCFFFFFHHHHHJJJIIJJFHIIJHIIJJJJJJJJJJJIJJJJJJIJJJJJJJJJJJJJJJJGHHHHHFFFFFEEEEFEDDDDDDDDDDDDCDDEEDED#
@7V6
CTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIIJJJJHIJJJJJJJJBGHIIIHJJJJIFHIIJIJJJ=EHHHHFFFDDDDDDDFDFDDDDDDDD#
@7V7
TGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCC
+
=?8A4@)<C????CFEFFBAEDH@9CHGCEGI<7?FA6;4==CEFEEEAC>=;?DB=@>AC@;2;AB>ABBBA@AB>A:ABB@A:@AAB>98?7?>935
@7V8
CTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
CCCFFFFFHHHHHJJIJJJJIIJJJJIJJJJJIJJJIJJHIIIJJJJIHIIJIJJJHIIJJJJJ@EHHEFFFFFD;ACDDCDDDDDDDDDBDDDDDD>
@7V9
ATTTTTACTGTCTTCTAAATCATCTTTTACTTTGAGAAGGCAAGCATACTCCTCTTGTAACTCTTGATAGTTAACTTCAAAGTTTTTTTCAGCAAATGA
+
CCCFFFDDFFDCFEHHIIJJIJGGIIIIIJIJGHCHIJIIJIGIGIHGJJJIIGIJJJIEGGA@HHIICIIIEGDEGHIGGFEHHHFDBDCCDCCCCCC
@7VA
CCTGTGACTCTCACCTCTCAGACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGC
+
@@CDDDDEFFFFBEGGHHEHCHEFHG?FHA>EGGAHIJC>:::D@?DGHIC@C7BG@@G@GFHHI>EEIHHFEF8BFBCEEEEDDC>>?8;<;CC>@88
@7VB
GTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTN
+
CBCFFFFFHHHHHIIIIIJJHIIJJJJJJIJJJJJJJJJJHIJFHIJIJJJJJGIIHHHHHFFFFFEEEEEEDDDDDDDD?CDDEEDDDDDBDDDDDDDD#
@7VC
GGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCN
+
CCCFFFFFGHHHGJIJJJIGIJJJJJJJIIJIGIFIIIJJIJGHIGIIJJJJJJJGFGEG@FCFHHEHEEHHFEEDFFFFDCECEEDBDDDDDDCCDDDD#
@7VD
TGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACN
+
CCCFFFFFHGHHHJJJJIJIIIHGJJIIJJJJIIIJJJJJIIGIIJIGGIIJIBFGBHIGAAEHHHHHFFFFFE;AC;ADDEEDDCDDDDDDCCDDCDDD#
@7VE
CTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGTTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGCTCCAGTTTGGGGTGGGCAACTAGTGGG
+
@@@DDDDD?BFADFG<<?B><<3BC:??D9F;?9*:*????4)?/*09BFA48CFD<)88CA=C));(=?:))(,);;>6;,39,82<(((234>+488
@7VF
GGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCN
+
CCCFFFDDHHGHHJJGIIGGHGIIIGGIGIGG?GHHGIIJHHIIJIFHHIJJIIJIIIGGGEGIIJHFDDCEC;>CE>CCDDACDDBDDCCCDDB@CDDD#
@7VG
GCTCTTCAATCTCATGCTGCTTCGCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACN
+
@C@BDDDFHHHFFGIIIIIGGIG1@FCFHGIGEHGGGIIJIIGIGIFIJJIJIJGHG=F@BHGHIHFEHAA;;BDCDEEECEECCDDDDCDDDDCCA@@?#
@7VH
CTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGN
+
@@@BDBB;C=CDFDH<<<AACFHIGHE@@A1CB@FCGIGDF?F;0B3867?FH;=;FFGA;D@@GEHB5;B;3>>@:<CCC+>CD::>4<4@?8A<<22<#
@7VI
CCCAGGTGATACAGCTGGCGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGCTN
+
CCCFFFFFHHHHHIIIJJJGGHGHEEHGIGGHEIGGGJJGJGGIJIJIHHHGFFFFFEDEEDDCDDDDDDDDD=BDBDDDDDDDDDBDDDDDCDDDDDDD#
@7VJ
CTCCGGACTCCTGCCCATAAACACCCATGCTACTGGGCTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDEEEEDDDDDD#
@7VK
TCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATN
+
CCCFFFDFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJGIIJJJJJJJJJJJJJJIIJJJJJJJIIJJHHHHHHFFFFFFFEEEEEEDE#
@7VL
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
@@@FFFFFHHHHHJJIJJIIJIFFGIGGGGIIGHDGGHIIIJJJCHIGFHIJJIIIIJJGIIGGGIFIJJCHEEBEDAC@@ACC@BDDCDDDDD?CCD
@7VM
GGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTN
+
CCCFFFFFHBFHHJJIJJJJJJJJJJJJJJJJJIIJIJJJJJJJJIJJJJJJJHIJJJJJJJJJJJJJJJJHHHGHHHFEFFFFFEDDD?BDDDDCDDDD#
@7VN
GGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGGAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCN
+
@@<DDBDDF?FDAE9C<:CDIH>FFH9<AC<@E@E131:DF:B?AF4BBG1BFGA8:@&0;<8<<<?C?@BCB>CC38?CA>>>ACCA:::<A<<<B@BC#
@7VO
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTN
+
CCCFFFFFHHHHHJJIIJJJIIIJIJJGIHIJJJJJJJJIIJJGIHHJCHIIIJIJIJJH=CEFFFFFFFFEEEEEEDDDDDADDDEDDDDDDDDECCDD#
@7VP
CAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGN
+
BB@DDFFFHHHHHJJJJJEHIJJJJIIJJJJIJJJJJJJJJJJJJJIIEGGFGIJIJJJIJJJJJJJJIJJFHHHFFFCDD@DBDEDCDDDDDEDDDDDB#
@7VQ
CTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGN
+
@@@FFFFFHGHHHJJIJJJHHHHIJJJJJJCHIGHIJIIIJJIJJJJJJJJJIJIGIJJJJJIGHHHHGFFFFFEEEEE@CDDDDDD8ABDDDDDDDD<A#
@7VR
GCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCN
+
@@@DBDDDDDDFDBHA?@@@@GE9AC;=CD?BD)666>A(=5>AC;CCCCCC@B@>>>@@C7&&)>>>@(28><?>:>@<<C?<C?:>9A?>@@>CD:(2#
@7VS
TTAACTTCTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGN
+
@CCFFFFFHGFHHIIGIIGHCFHIIJGHIIIJJIHEDIIJIGHGIJIIIGGIIIJJIJJIIJIIJIGHIIJGFGFGDIGHGGGHHHHHHFFFFFFDDDDD#
@7VT
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFHHHHGJIJJGHIIIJJJJIIIGIJIFGIJIJIJIJJIJJJGGJJJJIGIJGGHFFFFF=>BDDDDDDDDDDDDCDDCCDCCCCDDDDDBBDD#
@7VU
AACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACN
+
;114=B4:C4A2A<EEEA?FFEEDD?;??CEBCEF3CDDD3*?B9099??8@A(.5;@=AA@CD5=3??A>@@AA;;5??AAA???3;?A>AA<>A<4:>#
@7VV
GAGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTN
+
B?@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJGHHIJIIJJJJJJJJJJJJJIHHBFDDEEEEDDDDDDDDDDDDDDDCDDCDDDBDDDDDBDDDDE#
@7VW
GGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGGGGGAAGGGGATGTTTN
+
@@@DDBDDHDHHDBG;:;<@FH@:D9:CD6:?BD>09?BGHHBB==@GA@=@7=6).:5=9.6>665;;5@CCC@@59>::,,<&099-9@?>5))<@>A#
@7VX
TGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGN
+
BC@FFFFFHHHHHJJJJJJJJJJJJJIGJJJJJJIJJIJJIJJJIJIJJJJJJJJJJJIIGIIJIIJJIJJJJHHHHHGHFFFFFFEDEEEEEDDDDDFD#
@7VY
CCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGN
+
?8?A=D=2++2A<<<AA<<FB<<<A9CE:0:CDE<?3D?9??*?D?(BBCIB5855.=7@?=7ADDD363(;A>6>5,5,,5,<((,,,:(:(+:>A<A:#
@7VZ
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@CCFFFFFHHHHHJJJIJJJJJJIJJJJJJJIIJJIJIIJJJJJJJIHIJJGIIIHHDGHIJII4ADDACEEECD@CDDDDBDDBDDDDDDCCDDDDDDD#
@7W0
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
CCCFFFFFGGHHHIJJJJJJJJJJJJJJJJIJJJJJJJJJJJGIGIIIJJJJJIJJJJJJJJIIIJJJJJIIJJJJJHHHHGHFFFFFFFFEEEEEDDD
@7W1
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
CCCFFFDDFHHHHJJFHIIJJIJIIJIGIJJIIJGJJJJIJIIIJJJJGHIGIIJIIIJIDFEEEFFEFFFFEEDECDCCDCDDCCDDDCCDBBDDDD<>#
@7W2
ATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGN
+
CCCFFFFFHHGHHJJIIIIEHJIIGIGJGIJJIJJJIJIJIGIGDGHGGIHIJIJJIIJFHHIGGIJGHIHGHGEE4=BD=CCCDCCCCAD<BDDBBBCD#
@7W3
GGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGN
+
BCBFFFFFHGHCFGIIHJJIIJIJJJJIJJIJJJJEHHIIIJJJGIJJJJJJIIJJIGHIIJIJJGHHHEFHFD>DFFDDECEDDCCDDDDDDD5=B9@D#
@7W4
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJJJJIJJFHJIIJJIJIJJJJJJJJJJJJJJJJJJJIIHHHFFFFFFCEEEEEDDDDDDEEEEDDDDDDDDDDDDDDDDBDDD
@7W5
GCTGGACCTCCAGCTAGAGCTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTN
+
C@@FFFFFGHHHDIIJIGIGIGHHJIIGHJJGJJIJJJJJIJJJ@HGIIJIJJJHGHGIJJIIEHHFFFFFFEECCCDDDDDDBDDD5>BDBDDDDDCC@#
@7W6
GCCATCATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTG
+
@@@DDDDDD>D?FHFGB>HHIIEI;AEHIECAFEFG?DD@DFH@FFDHGDHDGIII@DG>FGC==FFGFHIIIA=CG@>=AEHHEEEEE;C@AC6>C@;
@7W7
GGATATTCACATGTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCN
+
@@@ADFDFFFDHHIEHGHHFHGIIG@HF9<BFEDHAEDGHGGGHIGFGGIE?DGEFEFH@CCFHIGG7C=C@>7?AAAC?BDBCB>@DCCCCFD;AA>;;#
@7W8
AGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTN
+
CCCFFFFFHGHHHJJJJJJIJJJIJJJJJJJJJJJJJJJJHJHHIIJJJJJJJIIJJJJJIJJJJIJHHHHHFFFDDDABD?BDBDDDDDCDDCDDCDD@#
@7W9
GCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCN
+
B@CDDDFFHGHHHIJJJIIJJJIJJJJJIGJIIJJIIJJJJJJJJJJJIJJIJIJJIIJJJJJJJJJJJHHHHHFFDDEEEEEEDDEEDDDFEDDDDDDD#
@7WA
CTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATN
+
@CCDFFFFGHFAFGHGIIIJIJJJIJIGIJJJJIIJIJIIGGHIEHGGHIJIIHIJHIIHIIIJGGG@DGHEHCHHED@CFFFFDEEEDEEDDCDDCCDC#
@7WB
ACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTN
+
CCCFFFFFHHHHHJJHIJIJJJIJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJJIJJHIIJJJJJJIJJJJJJJJJJHHHHHHFFFFFFEEEEEEE#
@7WC
CTCGGAGGGCGTTGAGGGAGGGAAGCGGAAGTGGCTACCACCCGACGGCACTGGCGGGGCACTCTGGGGCACTGCACCCCCAACCAACCCCCCATCAATGN
+
CCCFFFFDAHHDHJGGFIJJJJDHGIJIIIJGIGGHHHHFFFFDDDDDDDDDDDDDD7@&&2(9:4@C;&&2(+4(:??BB&(2902(5@D&)&(+(4(:#
@7WD
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJJJJJIJJIJJJJJJJJJJJJJJJJJJJIIJJGHHHHFFFFFFDEDEEEEDDDDDDEEDEDDDDDCC
@7WE
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@@@DDDD=DHFFB@?GHGGH@@D>BFEHHIIGGHED99?@@A???BB?FHC>?FG<FBFCECGG-:?B8ACCCCCCA?@??/89?BCCCBBCCCCACCC4#
@7WF
GTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGG
+
CCCFFFDDDDFFHIGHEFHGH?FHIEGCFHGHFIGHGFGGHBFHGDCHAFGHDFHIC<CHGCHFGG;EHE?>CDDCC@>>@CC@5;=5(5<CDDB(38<
@7WG
ATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCN
+
@CCFFFFFHHGHHJHJJJHIJCGIIJJJJJJJJJJJJJJIJJJJIIHHHFFFFEFEEEEEDCDDEDDDDDDDDDDEDDDDDDDCCDDDDDDDDDDDDBDD#
@7WH
CGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGN
+
:@;B?DD6F)8DF@GFFDDG>9??9949B<BFFD884=F;F=3=;-)7@D;CCFAEDDB:BB;;@B;@>;(;;?->@@<6,5;>@;>5()+4:>:::@>>#
@7WI
CCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACAAAGGTCAGTGGGATTGTAACAACCAGAAATATTCCAACTATAATAGTAAGTATN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJIJJJJJJJFGIIHIJJIJJJHHGIJHHHHFFFFFEEEEEEEDDDDDDEEDCDFDBCF#
@7WJ
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
?@@FDDDDHHDD?AEEHDIHGGHGGECHCEHIIIIIIIIIIIIIEDGIGF?FHIIIDFHIIGGGADHDHGGGI=AEDFB@>>@CC@CCCDCA>CCCD?BC#
@7WK
TTTTTGAAAAGAAAAACTGCTTAGTAACTAGCAGAAGTGTTCCTAAAAGAGTCATACACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACN
+
CCCFFFFFHHHHHJJJJJJJJJJJHIJJJJJJJJJJJHIJIJJJJJJJIJJIIJJIJJJJIJJJJJJJIHHHFFFFFFED?BDDDDDDEDDDDDDDDDCD#
@7WL
CCAGGCAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGAATGTGGGTCCTTCCCG
+
;=?1A?AD?FFFDI?AFBI<CHBEHAB<GG>??FDG???C?9BD?@DEFGFBF48=C=F@CF=FD=7;CA@EFE4=B89;5((535:,,8?B?AAA999
@7WM
GGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTN
+
@@@FFDEDFHFFBE>FEGHHHCFHIGGIIJJIEIIG:@EHHGDGDGHI@EHGDGGFDG@@GCGGIEIIIGEEEHECBCBDF@CCCDBDBDBCCCDADC?C#
@7WN
CTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCAAGTN
+
CCCFFFFDHHHFHJIJJJJJIJJJJJIJJJJJIIGJJJJJJJJJJJJIJIJIIHJJJJIIJJJJJJJJJJJJJIJIIJIHHHFHFDFFEDDCDDDDDDD>#
@7WO
TTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGN
+
?;?DDDDD<DD>DDDEE:?;<B::CC<9CF9CEECEE>919*:CC*?@@DDDDE>C)...8;@8@DC@)7==;AACCAA:?/98=;55;>A<3>,,;>;5#
@7WP
CAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTN
+
@C@FFFFFHHHHHJIJHHJJJIJIJJIHIJIJJJIIJJIIJJIJJJJJJIJJJJJJJJJIJIJGJHFHFFFFFFCDEEEEDDCCDCCDDDDDDEEDECDD#
@7WQ
GTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTN
+
CCCFFFFFHHHHHJJJIJJJJJJJJIJIJJJJJJJJJGIJJJJJJJIIIJJIIIJIJJIJJJJJIGGJJJJJJHGHGHFFFFEEECEECDDDDDDDDDDD#
@7WR
CTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGTGGCTCCAGTN
+
?@@DBDDDDDFDF>FHIFBHE<CAEEBG3A@FFGDFGHBDHHCDGGCHFEGII=C@FHIIEIIGEGHIFE;CEHD@DBE?ABCCC@DACC;?89AA@CCA#
@7WS
GTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTN
+
@C@FDDFFFBDDBBH<@FGBHIGGHGAFHIFDB=:9BBBDD057BBD-7BC@CDECDBBB55<BBB&5>23:@C4>CDC>>:@@>5>9-9BDCDD92>>>#
@7WT
GATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACAC
+
CCCFFFDFHHHGHJJJFHJJJJJJJJJJJHIJJJJJJIJJJJJJIDHIJHHIJCEHHHHCDFFFFEEEEEEEDDDDDDDDDDDDDDD9>BDDDDDDDDD
@7WU
CTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCTN
+
CCCFFFFFHHHHHJJJJJJIJIJJJJJIJJIJJIJJIIJJJJJIJIIICHGIJJIGIGFGHHHFFFEFCBCDDDDDDDDDBDDDDBDDDDDDDBBB@BDD#
@7WV
GTTGACTAGGCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGAGCCAT
+
?@;D?B:A:2<D3AA<CFG?EBG?<ECHEE>FAG9FG@6)??B8//?DF>CFFIII((..=17AC;7@@D7((6;35;9,((,5:(5589?(((++89>
@7WW
CAGTATTCAATCCTCTCCAAAATGATGGCAAAGTTGGGCCTGTCTTCAGGCTGATGTTGCCAGCACTGAGTCATTATCCGGTATACAGGCCCAGGGCAGTN
+
@@@FFFFFHHGHAFBHFAEHDCGIIIG@GGHGHHHGDDCHIIDDGGHIIIGIIIIIIIIGHGCIGIIIGIGGIHHHHHHFFFCCDFECCBBBBBCBBBBA#
@7WX
TCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
CCCFFFFFHHHHHJJJHJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJJJJJHHHHF?ADBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@7WY
TCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTN
+
?@?DBEFFGH<FFFHHFEEHEGHIIJJFHIIJIJJIJJEHHJIJJIIJIJJIJJJIJJJIJIIIJGHGIGIIJHCHHIHHHHHHFFDEEECECCCDDCCD#
@7WZ
GTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCN
+
@@@DDDADDHFHHIE<A>AABCBBB;;6@B@0)<A>CCDCCBB7@@BB@B-:@?CCC>:@BC>>@34::;;BB>BCCCCA<?9@CC?B@<A<+:A:@ABB#
@7X0
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@@<DAADDF?<?DA>CCGGBHGAEBA?<GGGHH@BGHC@CCGHHGI<=BFCHG=CE=DCAEH=:B86@;>AACC@6?B@ACCCCC>AC::>A<5058<>@#
@7X1
CTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTN
+
CCCFFFFFHHHHHJJJIJHGJJJJJIJIJIJIIIIIJIJJJJJJIJJJJJJJJJJJJJJHIJJJJJIJHIJJIJJIHJHIJGHGIJGHFCAHEDE@CDDD#
@7X2
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFFFFHHHFFIIIJJJJJIJHHGGIJJJJJJJJIHJJJIJIGHJJJJJJJJJJJJHHHHHFFFFFEEEDED>CDCCCDDCDDDDDDDCDEEDCCDD
@7X3
GTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTN
+
@BCFFFFFHHGHHJJJJIJJIJHJIJJJJJIIJJDGHIJJGJJJJHIJIJJJHHHHHFFDDDDDDDDDDDDDDDDD@CDDDDEEEEDDBDDBDDDDDDDE#
@7X4
CCTTATGCCGTGTTTTCATTTCCTCCATCTGTGCCATGTGTTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCN
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJJIJIJJJJJJFHIIJIIJIJJJJJIJJJJIHJJJJJJJJJJJIJJIJJJJJHHHHHFFFFFEEEEEEEDDDD#
@7X5
CTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGAC
+
@CCDFFFFHHHHHJFIIGIEHIIJJJHJJJJJIIJJJJJIJJJJIJIIIHFIIIIJJJJJJIJJJJJJJJIIIHIJJHHHHHHFEFFFFEEEDED
@7X6
CCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCN
+
@C@FDDDFFFHFFGHGGAC@EFHHHHIIIIIGEHHGGCHIIJIEIGIJIIJJIIJJJIIDHHEHHHFHFFFDDDDDDACDDDDDDDBDBDDE@CDDDDCD#
@7X7
CCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGN
+
?<?DDD>?DAFA=FCF=A:F?GGAHIAGEGGEHGIG@CCBDHBFFEG>=@GGGI=ACADDBAA@>CCCCC::<@CACCCBBC9ACC@@ABB?CCACC>CC#
@7X8
CTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGN
+
CCCFFFFFHHHFHIJJJIJJJJJIJJIIJIIJIHHJJIJJJIJJJIJJJJJJJIJJJJJIJIJJIJJJJJJEHFBDFFFEEEEEDEEEDDDDDDDDDDDD#
@7X9
CGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGN
+
@@:AB=ADFBCFB>?EFB>FGG<HHDHIIGIHAD@GGCADAFHC38BFHF<8CHEHG9C;==AEI<=?>EB?(?(;(6A5;(5;B@((,;AC:5:CCC:A#
@7XA
CCCCGCTCATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTAC
+
@@@FFFFFGGHFHJJIIIIIJJJJIJJIIJJIJJEIJFHGIJJJJJJJJIIIIIJJJJJIJJIIJJGHGIJIJEIJFGHHFHFFFFFCFCCEEEEECDD
@7XB
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ@EFDEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@7XC
TTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
@@@FFFFFHFDFHIFEHHIJIGGHIIJIJJEGIJIGEGCGGGIJEHGIJJ9BCEEAEEDBBDDDDDDD=BBDD<CCCCCDDCDDDDDD(>@CDDDDC
@7XD
CCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGN
+
CCCFFFFFHHHHHIJIJJIJJDHGIGIHIJIJIFBEHGIJJGGGHIBFGIGHHIHJJIIJIIJIGGEHHFFFFFFEEEEEDDB8?@DCCCDDA>CCDDCC#
@7XE
CTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGN
+
CCCFFFFDFFHHHIIJJGGJIIGIJJJIIIJHDFEHIIIFIIHJ?DFGIGGIIIJIJHHIJJIJFEHIGGGFECDFFFCECEC@CCBACDCDCCDEDCCD#
@7XF
TCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCN
+
CCCFFDDDFDDHHGIGJIJJJJIJCHHIIGIEEGEGCFIIJJGJGGHBDGIGGHJGFEECEEACHHEEHEHDDFDB@DCACCDDCCCDDCCDEDCCCDDD#
@7XG
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
7?@DADDDDFHHBEBDHAFBGGGIIBFDA><B?GGG@BA9FGGH@GIIIDIIIIIGIECA;;AEEE'9?35@>C:58@@B7@>A@CC:CCCCCB<>5>@B#
@7XH
TGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAA
+
@@@DFDFFDHGHHJJJJHJIHEHH@FGIIIIGIJHGIIHIHGIIIIGIIJIGHIFGHIIEHGHEHGHHFDDCDDCDDCDDDDDDDDDDDDDDCDDDD
@7XI
CCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTTAGTTCCTCTGTAGTTTTCTTCAGCTGACGATCAAGGTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJIIJJJJJJIJJJJJJJJJJIHHHHHFFFDDDEEDCC#
@7XJ
CTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTN
+
CCCFFFFFHHHHHJJJHHIIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJHHHHHHHFFFFFEEDDDDDDDDDDCBCC@CCCD:#
@7XK
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
CC@FFFDEHHHGHJJJJIJJJIJJJIJJJJJJJGHIIJJJJJHIIJFHIJJIIJIIJIJJJJJJJIIJIJHHHFFACCDECEDDDDDDDDDD<CCD@CDD#
@7XL
CTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTN
+
CC@FFFFFHHHHHJJJHHIEIGIJJGHIJJJJJJJJJJJJJJJIJGIJJHHHHHHFFFFFEEECDDDDDDDDCEDEDDDDDDDDDDDDDDCCDDDDDCDC#
@7XM
CTTCATTTAGAAAACTAATCTCACCATGTTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJHJJJJJIJJJJJJJJJHHHHHFFFDDEDEDDDD#
@7XN
TGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTN
+
CCCFFFFFHHHHHJJJIJJJJJJIJJHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFEEEDDDDDDDDDCCDEDDDDEDEDE#
@7XO
CCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
@?@??=BDDFF:AEDFGDBFHHF>9E><?CH>GFDEEDCFCGA@GEEFFIIFFEFGE3CFCEFDFE@C7?>@B=B=;?>BAB;>>?;AAB?@BBB@BBA
@7XP
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
:?@;4BD?DFD?F?G<<C;F:FFAC@??B1:CD91:BDDCF>DDFE*8DFEADFIDBCBF@@FF=@EI:@;=AB6;>;>6;@>@?BBB::(;>??(:8
@7XQ
CAACAAACTACTTTTCTCTTCCTGCAATGCCGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCAATTAGTN
+
?1=D;=2A32A<DG>FGIECHFI9FFF>GE+)1)????DGEEDD9BD3/**)8==B;3.))7@)()7).=AEEFD);.7;@A3;>@>?;?;3((((((5,#
@7XR
CCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACN
+
CCCFFFFFHHHHHJJIJJJJJHGIJJJJJJIJJJJJIJJJJIJJJHGIGGIJHHHHFFEFDDDBCCDDDDDDCDDCDDDDDDDDDDDDDDDDDDDDDDDD#
@7XS
CTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACT
+
@@;DDBBDBBFBAC<FDCIHGGIGGHICCHHEBFDDDGEDFGAFG>DHIIEGHG@:@BEGCDGHI7@GHEHECE@@??@CCCCECCCCFC@CADCCCCC
@7XT
CTTGATCTTTTCCTCTTGAGCAAAAATAAGCTCTTCTTTAAGACTGCAAAGAGCTTTATCTTTTTCATTTTCCATATATTCACGAACCTGATCCACATG
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIJIJJJJIJHHHFFDEEEDDDDDCDD
@7XU
CTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGN
+
CCCFFFFFHHHHHJJGIIIJJJIJJJJJJJJJJIIIIHIJIJJJIIJJGHIIIIJJFHIJJGIIJJJIGGGIHGEHHCHFFDDDDDBDDDDDDDDDDDDB#
@7XV
CGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGGTACACN
+
@@@DDDD?AFFBADFFIA<FGDAGIFFFIFD?BGGFFI?FEIIFFFIDIFIIIEIFEFCEDDDDDDDACABBBBB@B>AABBB@BABABBB99>@B<BAB#
@7XW
GGGATCCTTCAGGGCCTTCACAGCCACAAGCATCTTGTCCTTGGTCGGGCTGAGGTTGTAGCACTCGGCCAGGAAGACCTTTCCAAAGGCTCCCTCACCCN
+
@C@DBDEFGHHH?BFHGJIJIGEEGGGHIFGIIJJJFGGJJJJIGHIIJIJIJIIIJHGHGHFFFFFACDDDDBBDDDDDDDDDEDDCCBCDBDDDBBDD#
@7XX
CTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIIJJJHHHHFFDDDEDDDDDCDDD#
@7XY
ATCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJBFHGHJJJHIHJJJJJJHHHHGGFFDEFDDCBDDDDDCDDDDDDCDDBDDDDEEEEDDDDDD#
@7XZ
CGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCN
+
CCCFFFFFHHHHHJJJJJJJJIIGIJJIIJIJIJJJJJIJJJJJJJJJJIJJJJIJJHIGHHHHHFFFFFFDDDDDDDDDDDD8ACCDDDDDDDDDDDDD#
@7Y0
CTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATN
+
<==DDDDD?A:@FBFFBF:8<C?<<CFCFF<EFFCAFDA>*0BG??;GF:1?@@9;@=@=@;;@@7=CEC;AA;?'9<@=B=@<8ABB:@>@>:@44>>@#
@7Y1
CTCGAGTCCCGTCTACCAAGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTG
+
@C@FFFFFHGGHHJIJIIJJFDFGHIIIIIJJIJIIIJGHIIJJJICHHJJJIJIJIJJIIGHIJJJCHIGEHEHHGFFCEEDBCCEDDDDD
@7Y2
ATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCAAATTN
+
CCCFFAEFHHHGAHFHGEEEHIIIIIIIIIIIIIIGHGIDHIIIIIIIIGGHGIIIIBECGGCGGCHICHHCHHHGEEFDDFDEEEEEECCCCBBBBBCC#
@7Y3
GTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCN
+
@@@FDDEDFADFHG<?CGIEGIIECCHIGIIAEEHCGHDF@CHEGIIIIIIIGFFECFHGIGGDCBBCECCCCCCA@CCCCCBBCCA5<>BBCCACCCBC#
@7Y4
GGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGGGGTGGTGACTGT
+
;;:BDADDAHAD??EHGHE?AA<CEGIIIG>?GB@F9?F93?FFA@G;FBFCBCAAGE@C8DCGA:;3?==;)7?;7>95;>=@?'35059&8::34+
@7Y5
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
@?@DDDE;;FDHDBGHHEDFHHDHHGEGHGGEBEGDBFED@GDGHGIG@CFCHFHIIG5AD=CCCE6;?;:@<:@CC:@>:>>:@AB5)5+<:>CCC:3:#
@7Y6
GGGATGGAGACAGGGCGGCACTAGGTTTCATGCTCATATCCGGTCCCGGCAATGCAGATGCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTN
+
@@?BDDADFFDDDGFBEGEHBHGCGDCHGHHCGHCEGGIIIIIEB???A?>?CA>@::>>:@@CCC4<;+0?A@C@BB@BBC@C:>?A@@ACC??C94>C#
@7Y7
CTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCAT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJHIIJJJJJJJHJJJJJJJJJJIJJJJHBDDDDDDDEDDCDDDDDDBDDBDDDDDDD
@7Y8
CATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCGTACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGN
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJIJJJJJJJHHHHFFF@DBDDEDDDD;@CDDDDDDDCDB@DDACDDDDDDDDDDDDDDDDDDCDDCBDD#
@7Y9
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJFHIHIJJJJJJJJJJJHHHHHHHFFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEEDCDDDDD#
@7YA
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
CCCFFFFFHGHHHJIJJJJJJIJJJIJJJJJJIFIGHIJJJG?DHIFHIJJIJDHIJIHHFFFEEEEEDDDDDDDDDDDDDCDDDDDDDDDDDEDDDDDD#
@7YB
GTTGGACTGAGAGAATGCCATATTCACGTGTCCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGACCTCTGCAGCTGTGGGTTTCTTTGCAGCCN
+
CCCFFFFFHHGGHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJJHHHFFFFFEDEDDDDDDDDDDDDDDDDDDDDDDDDDD>BDDDDDDDDDDD#
@7YC
CGCTCGAGGCACTGGAACATGAAGTGGCGTCGAGGAAGCGTAACTCGGCACTGGGCTCTCTGGAGGTGTATATGAAATTCGTTCCTGCTTAATGCTACACN
+
CCCFFFFFHHHHHJIJJJJJJJJJGHJJJJJIIJJIIIIJHIHHHHFFFDDEDDDDDDDDDDDDDD?AACDDEEEEDDDDBDDDDDDDDDDDEDDDDDDD#
@7YD
CGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGN
+
@CCFFFFFHHHHFHIJJIJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHGIJJHHHHHHHFFFFFEDEEEDDDDCDDBDCDDD<BDBD#
@7YE
GGCTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGC
+
CCCFFFFFHHHHHJJJDDDDDDEDEDDDEDDDDDDDDDD98BCCDDCDDCDDDDDDDDDDDBBDBBDDEDDEDDDDDDD?CDDCCDDAB4?BDDBBDDB
@7YF
TTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGN
+
@@@DDDFFHFHHHDHIIJJJIIIGJJIGGIIFHIGIIGIJIIEIGHICHIIIJIJJEGHGGIEFDFFDEDEDD?BCDDDDDCD@BDDDACCCD@<?BB8@#
@7YG
TTCTTGGCTAACAGGAGTATGTATTTTCAACATGTCTTCAAGGGTTTTCTTTTCATCTTTAAGAATGCTATTCTCTGCTTCAAGTTGTGCAAATTTTTCTN
+
@@CFFFBFHHHHHGGHHHGGE:CFHGIGGHICHEEDBF>FHIII?FGIIIGHIIHGIGIGGIG<BFFACACD=AG@EADHEHHGEHHBB;@DECCCECEC#
@7YH
GTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCC
+
B@@DFFFFHHHGHFHGHJJJIJJJJJJJJJJJJJJJJJJJIJJJJGIIIIJJHHHHGIGIIJIGIJIJJJJIJIIHHHHHFHEDFFFEEDEEECDDDDD
@7YI
GGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGT
+
?@;DDDDDF?AD:8E;F@8ABGE9C@<DF?:D*:BDB@FGC@DB?*BB@FFCFFGC@=@C2@?E??7?BB@CB=;=(-;A>ABB?<@<>9@BBBBB33(
@7YJ
GTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGN
+
@CCFDFFFHHHHHJJJIIJIHIHIJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJJHIJJHHHHHFFDDDDDDDDDDDCDDDDDEEDDDDCDD#
@7YK
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCN
+
;=?D?DDDFF?DF>D@+A<F:1CCD>FFD9?<FFD;B??BB/??=BBFFEEFE)7@;@:.7)=A773).).==@>;>A5@B>A@@:>A;;(:AAAB><?@#
@7YL
GCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCN
+
???DDDD?DDBDDEE3C:A:<<3<CFFDFEDE@E=<8)?DA>DE3*?@DE<DDD@DD2AD;AA>C3=;)7?A>AAAAAA>>>;55(,(5>>>:>AAAA>>#
@7YM
TAGAGTGGCCACAGGACCTCCTTCCCCGGTTGTCCCATGTGGCCCTGGCCAAGCTTTTTCCAGGGGCACAATGGGGACCAGTTGAGCAACTGGTGGTGG
+
?<8BD,BBF::ADFFABCFGEEHEF@B8?0:DGFGIIEFDFB;=BFA68@;6C@EEFAAEDE>BD8=;?;2>>B??1888<:>A>AAB<<9?>49<0<@
@7YN
GTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGN
+
C@@FFFFFHHHHHGGJJIJGHIJJJGIJIJJJIHIJJJHHGFFDDDDDDDEDDDDDDDDDDDDDEDDDDD@CCDDDDDDDDDDDDDDDCCDDDDDDDDDC#
@7YO
CTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATG
+
CCCFFFFFHHHHHJJIJJJIJJIJJIJIJJJJJIJJJJJJHJJGHIJIJJJJJJJIJJJJJHJIJIJJJJJJIIGIJJJJIJJJJJJIHHHHHHDFFFF
@7YP
ATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGN
+
@@?DDFFFHDDHHGIGGIGIGHICFEH?CFFHIGECDCG>9?GHIEHGHGDCHEHHGGIIIFAEE5??@CE@CCCCECCC5=B2:ACEDCCCC:CBB@:4#
@7YQ
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
BC@FFFFFHHHHHJJJJJJJJJJJJGIJJJJJJJJIJIJJJJ:BGIGIIJIIJCHIIJHHFFFFECEEDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDCC#
@7YR
ATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCN
+
?==?DDAACBHHHIB@1EF=?CDEGE?E?<;GG<<HDHGEC9967C>CAAHGCHIIIDEAEA>B??BC6?A;>CB=@;9?>AC<@C5><4@?BB<5??4>#
@7YS
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
@@@DFDFFDHHHHIJJIIJIGIIIIJJJJJJJJJJJCGIJJJJJGHDGGIJJI7@GI@CEHHGGCDFFFDDDBDDDDDDDDCCDDDDDDDCCCCBDDDDC#
@7YT
GCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGACCATAGGTTCCATAGCTN
+
?@8BADDDHHHHDGICFB@HHIHGC@E:CFHFEFHIEHEHHIGHGHIGCGHHGIGGEGGH)=7?EBEEEEECCCCDCCBBC?(9?CCCAC:ACCEECCCC#
@7YU
GACCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCT
+
C@@FFFFFFHHHGJIGHHGIGIGIIJJJIJGIJIJJIFIIJIGIIGJIIIJIHGHHGBDEFDDDDDCCDCDDCCCDDDDDDDDDDDDDDDCDDDDCCCD
@7YV
CTTGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTTCGTTTCCATTAA
+
@@1=DDDFDFHHHGHIIGIIIGHIGIIEHBBFFHFGDHG@FGBGGHGIIIHHEEIIIHGGGEHH@FGIIGGHGIIHHEFEDF?<BEEEBCCCCCEEDCC
@7YW
GGCGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACN
+
:?+4AD;BDA??DE9<C<FABEFF>93?E>@D@DDDEDCD8?9DECB=)=;<(5@ACDDDDD..;>@AAAA>>A>A?????>?AA>??>?>>>:>AAA3<#
@7YX
CAGGCATGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGGAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGG
+
+=;?:DB?BDDDDB?2+:A?FFEEED<6:?BA99?BCD@D?<CABC>C>;ADDA>A(=;?DA@;;;5>-;;5,>9AAD:A>:>5<><AAAA>AADA>><
@7YY
AAACCATCTATCTGCTGTTTATAGTGAATGCCTAAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAA
+
CCCFFFFFHHHHHJJJJJJJJJJJHIGJJJIJJJJJIJJJJJJJJJJIJJJJJJJIJJJJJJJJJJJIJJGIJJJJIJJIJ
@7YZ
GTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATGATTTCTCTTCTGAAGTTCTTCGACTGTCCCCATTAACTGTTTTATTTCTTCAGAAGACTGTCTN
+
@@CFDFFFHHHHHJJGHIJJIIJGJGIJJIIJJJJJJJJJJJJJJJJJJIJJJJJJJIIHIJFIJIIJIIJIJJJJHHHHHHHFFFFFFFEEEEEDDDCD#
@7Z0
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCN
+
@@CFBDEDFDHFHIJJJIIDHHJIIJIJJIJIGJJJJJIJJGHIJIIJJJHGIIJIIJJJJIJJJHGHIHHGF?DCDEDEDCDD?BCDDDDDDDDDBABB#
@7Z1
GCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACN
+
CCCFFFFFHHHFHIJJJJJJJJJJJJJJJIJJJJIJIHIIJJJJJIJJJJJIJJJJJIJJGHHHFFFFDDBDDDDEDDDDDDDCDDDDDDDDDDDDDBCD#
@7Z2
GTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCA
+
CC@DFFDDFBFHGGEGFHIIIIEGIEDGFHCHGHCGHHFHIJJICEGEGGHHHGHCHH>E>8<=;?CDBCCCCADCDDCDDD<<A<@@BBBA@CCDDDD
@7Z3
GGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGAC
+
@7@DFDADDAAFFBGBACEDCCEECAEDCB>BB69?@DB@@8B6BB5B@BCCBB<8)0<<?:<8?ABD?BBDDD@C43+4<299(4:94>@@
@7Z4
CTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATCAGCCAAAGCCGCCTTTAGC
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJIJJIJJJJJJJJJJJJHHFFFEEEEDDDDDDDDDDDDDDDDDDDDDDD
@7Z5
GGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGN
+
CCCFFFDDHHHHHJJJJJJIJJJJIIIJJGHGIJJFHIJJJJJJIJJJHHIJIIGFHGHHFFFFFFEEACEDDBBDDDDDDD@DBBDDBDDDCC<?BDDD#
@7Z6
GTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACN
+
BBCFFFFFHHHHHIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJGHHHFFFFEEDEEDDDDDDDDDDDDDDDDDDDDDDDD#
@7Z7
GCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTN
+
@@@FFFFDFHHHF<CFCEHEDGEEEGIJGIJEHGGIJIJIEIIIIJGJIJIIGGIJIJDGIJJHFDDD?CDCCACC>CDCC:@?9?ADD?CCC>CCDDCD#
@7Z8
TGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGN
+
CCCFFFFFHGHGHIIIIJGHGHGFFIJIJIIIJJIDFHIJJJIJIIJJJIIJJIIIGGHIJIIHCEAEEDEFFFCEECEED5@C?@ABD5>?BCDDDDDD#
@7Z9
ATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGN
+
@@?DDDAB=A<<CF?;EHGGHHIGIIICF@B1?CF;CCFDHBDHIIHEDFIAH-@C@?HCAE@@?;?ACBBBB=CC5>CC?<(804>:>>>@:44:>A>8#
@7ZA
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHJJJJIJIJJJCGHGHJJJIJJJIJJJJJJJJJJJJJJJJJJHHGFFFFFFDEEEEEDDDDDDEEEEDDDDDDDDDDDDDDDDACDD
@7ZB
CCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTAAGAGTTTAACCTGCCGCCTTAA
+
CCCFFFFFFHFHHIGHGGICGHIJIIJJJJBHGIIIIJJJGGGIBDFIGEBEHIHIIEFHIJGGHIIJHFHFEHHFFFDFDAEEECCDDDDDDDD?BDC
@7ZC
CTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
@@@?DDDAHHH??FG?ECFHEH@DEHBFBBBA?FGGEF>DCHG)=CGG;BAE>EHHHB=@DD>A>C6@CCCACBCCCCCAACADAC>C@@CCCACCDC3:#
@7ZD
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
@@CFFFFDDHF?FHIHIEGIIGGGIIIHGIHHGDFCDDFGEHGEGGGBFHGCHGIIICGGCFA>5:?B>CE>CCACCDDBBB@BD?C>ABDDDCCCC@CC#
@7ZE
CCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCN
+
CCCFFFFFHHHHHJFHIJIJJIJJJIJJJJJJJJJHJJJJJJJIJJJGHHHHFFFFFECEEEEEDDDDDDDDDDDDDDDDDDDDCDEED>CDDDEEEEED#
@7ZF
CTCTATACACACACAGCCGGAGGTCATACTGCATCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATN
+
@@@DDDDDDFFHDGG;EFA::@A:CDEFGIBBCHGGIGG@FBCCBFGHHIGGGGICCEGGFDEAEE?@DCCCB8=;<@?>AB@<<9B<AAACDDCDCC?@#
@7ZG
GGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCC
+
@@CFFFFFHFHHGJIJJJJGHGIIIGJIIIJIFHIJJEIIGIIJJIGIJJCEGGHGIEEEHHFFF7>ADCEEEDDDDDDD>CCDDDDDDDDEDDD@CDD
@7ZH
AGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGN
+
@@@BDAD<DFHDFIIEHIAEGHE?FGGBGHGGHFAHIGIIIGGGIIFGHIGADCGIIIIEEEFFFDFCCEDEEEECCCC@CCDCCCEECCCCCCCCB@BB#
@7ZI
AAGACAGAAAAATAATTCTGTGGGATCATGATCTGAATCCTGAAAGAGAAATAGAGGTTCCTGATCAGTATGGCACAATCAGAGCTGTAGCAGAAGGAA
+
CCCFFFFFHHHHHJJJJJJJIJJIIJJJJJJJJJJJJJJIJJJJIJJIHJJIIJIJJIIJJJJJJJJJHHJJIIJHHHHHFFFFFFEEDDCEDDDDDDD
@7ZJ
TTTCTGTTTCAATTGTTCAGAAAGATCAGACAGTCTCTGTGACAGCTCTAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCN
+
=@@?D?BD>??<ACEC:A<FFC9EE>H<3+<CE9E9CF<1:C?B?DD9>?GEFH><BAFHHE=@F46;78@7@GE@@7?1?ED>BBE77@CC6;;;5>B@#
@7ZK
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
@BCFFEFFHHHHHJJJJJJJJJIJHJJJJIJIJJJJJJJJJIJJJGIJJIIJJJJJJJJJJJJJJJFBDEFECEEE>ADDDDDCB?BBCDDBCDDCCCDD#
@7ZL
CTCAAATAAAGTGCACAGTCCATGGCAGACCATAGAATAATGCAACAGGAAAAGCCCCTTTTTGTGTATTATTATTTAAAAATAAAATACAAACAAC
+
CCCFFFFFHHHFHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJHIIJJHHHHHHHHFFFFFFEEEEEEDDDDDDDD
@7ZM
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGN
+
@@@DBDDDFF??;CE@GIA:CFG<B@ECEFGIFIBGBFCGFDGIFDFE8=BCB<FFIIEFCDD;7;;=CDDDDDDEDA>;@>;;B:8A55>@@4:>BB4:#
@7ZN
GTGAGGTCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCA
+
@?@DFFEFGHHGHIIJJJJJJJIJIJJJIJHHGIJJJIJHHIJIIEHIIJIJJGHIJGIHGGGGGIGIJJJEECHEHHHHFDBBDFFFCCEECEBBBDD
@7ZO
GACTGTAGCAGTGGAGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCN
+
?;?D;BDDBDADA<+<AA3?FBFHH@HEEEF@FGIIIFEBCGCDG?;BDFEF<@FCFEI@CEEFFE2588;@593:>44<+3:@>A@BBBBB@BB@@258#
@7ZP
CTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGC
+
CCCFFFFFHHHHHJJIJJJJJJJJJIHJJJJJJJJJJJIJJJJJHIIJHIJGHJJJJJJJJJJJJIJHHHHFFFFEEEEFEEDDDDD@BDDDCDDD@CC
@7ZQ
ATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCAT
+
@@CDDFDFHBFFFHGIIGIJJIGIGIIAFEHGIJIIGBFI@FHGJJJGGBD8BACDDCD3?C3>BCACCDDACCDBDB@ABBCCDDDDDDDCCC:CCD
@7ZR
CCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACTTTTGGTATTAATTTGGGN
+
CCCFFFFFHHHHHJJJJJJJJJHIJJJJJJJJJJJJJJJJJHIJJIJJJIJJJJJJJJHHHHHHHFFFFFDEEEEEDDBDDDEEDDDDBCDEEEEEEDDD#
@7ZS
GCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGA
+
CCCFFFFFHGHHGJJJJJIJJIJIIJJJJGIJJJJIGHIJJIIIIJIIIIJJIJIIIIJJIIIGIIIIIHHFHHHHFFFFFFDEEEEEDDCDEDDEDDD
@7ZT
GTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCN
+
CBCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJIJJJGHIJJJIIJJIIIJJJJIIGIIJJJDGHFHHHHHFFFFFDDEEEDEFDDDDDDDDDDEDBDDD#
@7ZU
CGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGN
+
@@@DDDDDDDB>DE@<8CGHBB?HHCHGGGGIGDHG@EFGGH@G>BEFDBFHIIGIII@GBF=FEGHIGGAEECEDBDDEEEC6?@B=<5>:@:>C5;>>#
@7ZV
GTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATN
+
BB@FFFFFHHHHHJJJGHIJIIJJCGHJIJJJJJJBGHJJIJJJJJJJJJJJIJJJJBBEHHHHFFFF@CEEDEEDDDDDDDDDDFDEEEDDDDDDDDDE#
@7ZW
CAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTN
+
CCCFFFFFGHGHHGGIIJIJJJJDDDDCDDDDD@CDCDEDEDDDBCCDDABDDDDDDDDEDDDCACADCDDEDDDCDDDDDDDDDDCDDDCCDDDC>CD@#
@7ZX
CAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGG
+
CCCFFFFDGGHGGGGJIGGGGIIIJJJIEGIHGH?FHIJEHCHHIEDGIBFGIJHGHGFADCCHGEBD;@@>CA>AACACCCDDDCDCADFCDDC@A@
@7ZY
GGGGGTTGTCTGGAGAGAATACTGAAGGCATGATGGGCTGTGGAGGTGGCTCCCTGGGTGGGTGGTCTGGTGGGTCAGAAGTTGGTGGGAGAAAGGGA
+
@<;;DDDDADFHHCB@FHCGIDGFCGEIIIII@FHG@DFHHIIABFHFH>CEHGHGFBADCC39'3:@CCAC?5)+294:9CCCC2?@@?B>A?CBB8
@7ZZ
CTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTN
+
?@@DDDDDHGDFHIIIJJIIJGHCGGBGHIIJIIGGIIFJIGGGIIEHIHFFDEEECEBBDDDDCDDDB9?CCCDEDCCDDDDD<CD5>B8@CDDDDCAC#
@800
GCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGC
+
???DDBDA:D?DD:3<2@33<FDDEF<EEFC9?D3CE??CD>>??@0BD9?9?<(<83B.7;-77;C;;?CC;?7);?@A??@;;;:/(;8;;0;AA>A
@801
CACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGN
+
C@CFFFFFHDHHGIHGIIJJJGHIIEFFHGIJJGCHGGGJGHGIIEHGGGIIEHGCAHJIHGCEFFFB@CCEBD@BD?CCCC>ABBBDBCDC@CCDDDDC#
@802
CTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGG
+
?@?DFFFFDFHDFECBGHEGEHIFGECCAEFCHD1?DFHIIBHGGGII?BDBBH@C<@CD@FH@E:CC7==.:A/?36;;;;@A?B5;AC(5><9@C?
@803
GTGGGTTTCTCTGTAAACCAGGAGCCGTACGTCGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGN
+
@@@FBADDHHHDFHBHFHGHIGBFFFGFFHHCGFGGBF?=BFHGGHHFDHHIEEHFFBCCAEC@CCCC?@BB?CCCCCAAC@ACCCC@@@BB2<>BCCCB#
@804
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
CCCFFFFFGHHHHIJJJJCGHJGHGJJJJIIJJIIJJJJIJJJJJJJIJJJJJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDCDDDDDDDDD
@805
CTTCATCCATGGGTCCACCAGGCTTATTGAAGCCACCTCGCTCTCCAGCGCTGCCCATTCCACCGCGTCCTCCTCCCCGCCCACCTCTGCTCATGCCTCCN
+
@C@DFFFFHHFHGEHIIIJJJFEGFHJGGGEIIIAGGIFHIGGGGGGFGHGIGIIIGGHHFHHEFFDA?B@CDDCDDBDDDDBDDDBCAACCDC>@CCDD#
@806
GCCCGGGGCAGTCGAATTGAGGGCAGTCTGAGTAAGGATAAAGTTCTGAGTTTGAGAGGGCTCAGCTGACCCCCCTTCTGTCTTGACTTTGACAATGACCN
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJJIIJHJJJIJJJJJJJJJJJFHIJJJJHGHHFFFDECEEEDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDD#
@807
CTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGCAGTCCTTCAGTCCCATAGGTAACCCTCATTTCTTCCAGCTCTN
+
@C@?D=BBBDHHGB?@FHGIIEAFHIIHIGIFECE1DGEBBD@G9FIH?FDEGCCCFBC9DFGHIGG:=;=FHDH@:)7A;CABD@DFEDDCACCACCC>#
@808
AGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTN
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJIJJJJEHHHHHFFFFFFEECEEEDDDDDDDDDDDABDD;BD8AABDDDDDDDDDDDDDDBDDDDCCDCDD<#
@809
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTT
+
BCCFFDDFHGHHHJIJJJJJIGIJJJIIJIIJJJJJJJJJJJJIIIIJJIJJJJJJIJJIJJGHHHHH
@80A
GTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJIJJJJIJJJJJIJJIIJJJJJIJIJFHIJJJJJHHHHHHGFFFFFFEEEDDDDDDDCDDDDD
@80B
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGN
+
?@?D=ADA<DF???FA><E@@G?FFCCE<FBBFF@B@DFEBFFII*?FF@FIF8@@=F;@EA4=;BDDDDBCC>;;>A>@BBB?BAAB@5>4@ABBBBA3#
@80C
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
CCCFFFFFHHHHHJJJIIJJJJJJJIJGHIJIIIIJIJJIJ@HGIHGIIJIIEHHIJJIJIIEHGIJHHHHFFEFDD;>?>BB;@@AACCDDD@CCCC+8#
@80D
ACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCATCAAAGACAGAACTTTTCATTTTCACTGTAGTTGGATTTATTCTTTGCAAATGA
+
@@@BBD=DHHGHHIICFDGHII@BE@FHHHEBHI?E>DF?FDFCGDGIGFHIII@>DGGGIIGAFGGGIHEBC=AE@ACHEHEEEEEBBDFEDDA@CCC
@80E
GTGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTN
+
CCCFFFFFHHHHHJJJJJJJIJJIJJJJJJJJHHFDEEEEEDDDDCCEDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCCDCDDD#
@80F
TCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCT
+
@@@DBDEFFFDFFBFGIGGGDHFHHIHIIIGGGHGGIIIGIIGIGECFCGHIIGHIEEHHIIIIGGHGH7@FC=CAEGGHGIGFHHAABDCCFFDED;A
@80G
GTCCTGGCAAGCTGCAATAGTTTCTCTTTTCTAGGGCAGCTGCCGCAACTGTGCCTCCACAGGGAATCACACTGCTCTCCGTATCCCCAGGTACTAGGGTN
+
@;=ADB;;BBACDGAFA@AH<FA>HDHE@H>CG*CEHGB?9BFHDEEHIGF4=;;@@CGA7@E=C@D>@>@CCCC@;@C;9???5;A@CBB+>@AACC@?#
@80H
TGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTN
+
@@?DBDADHHHDHFIIIIGIIAFHHIGHIIDIIIGI>F<BGGIAGCF;FGFGEIIEHIIIIII>GH=@CHHEEECHB??BCBC;?C?CCC>CCCACCCCC#
@80I
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CC@FFFFFHHHHHJJJHHIJJJJJJJJJJJIHIIJJIJJJIJJJJJJJIJJJJIIJIJJIIDGIIJJHHHHFFFFFCCEDCCDD;?@BDDDDDDD8AC
@80J
GTGGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTN
+
BCCFDFFFHHHHHIIJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJHIIJIJJIIIHHCHHHFFFFFEEEEDEDDDDDDCDDEEDDDCDDDDDDCDDDDD#
@80K
CGAATTTGTGGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGC
+
@@@DFFFFHHHHGJJJIIJJJJGIJJIIJEHIJJIJJIJJJJJJJJJJIIEGIJHIEHHHEEHCFFFDCEEEDDDDDDDDCCCDCCC@CDDDDDCDDCB
@80L
ATCAGCTCTCGTGAGTGGTACAGGACTCTCTCCAGGCCAGTTCGGGTCTGACATGCCATAGAGTTTGTTTTCAATCCATGTGGAAGGGAGGGCTCGAGGGN
+
@@@DDDDDFHFDAHEIIII@B?,A@GBHFBEHEHEGDHAFFF?DB<G@GHIEGHDE>FH@CHB@?EHHHE@@DECA@>>AD@@ACC?628==-(<<&5>B#
@80M
GCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGN
+
CCCDFFFFHHHHHIJJJJGIJIHIJJJIJJJJJIFGGGHJJJIHIHGIJJJFHIJIJIIJJIJIIJIJJJJJJGHHHCHFFF>CDBBDDEDCDEDDDDDD#
@80N
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCN
+
CCCFFFFFHHHHFIJJJJJJJJIIJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJHHHFFFFFFEEDD;BDBDDDDDDDDDDDDDDDDDDDDDDDD#
@80O
GGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGAC
+
CCCFFFFFHHHFHIIHJJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIHHHHHFFFFFCEEEED@CCDDDDDDDDDDDD<CCDDDCDDC
@80P
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
;??BDDADADAHAF?EFHHIIII8:?CDG@FB?BDBHIAFGCF>GH>FHFF@GGHFE>DCCB3;AA@6;@=>@@C@CBACCCCCC>CCBCAB?:<AC>>
@80Q
TTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCCATCACAACCCCATTCGTTAAATCTTCCACGGTCTGGN
+
;@<D?;?BDFFD<>GB<B33AE<?DHIIFHFED@@4:C81:9?DC4BBGBDFFB>;DFEBF;8BB.@F;CD@E@:;;7A;7??=;;@AA>533;??@=9<#
@80R
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCN
+
;?;?BDBDDCCFDEEG@:CDFGGH<<::??DGFG@D>3BFG8DFH@CECGH<G@CEA44=CHHDC3@B>;@A@>BACCCDAACA@35@;>:>@@C3:ABC#
@80S
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
CCCFFFFFHHGHHJIJIJJJJJJJJFGIJHHIJJJJHGIJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDDDDEDDDDDDDDDDDDEDDDDDDCDDD#
@80T
CTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTN
+
@@@D?DBBFFF;FA:<BC@E<FFF<CGF)?ED<D>;:?D?BBDCBB>DF<=BBFD;@@DEB--;CAB@D@AC>AABBABB@?@<:5>>:@AA@@A>:@@4#
@80U
TCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTN
+
CCCFFFFFHHHHHJJIJIJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJJJJHHHHHADFFFFFFEEDEEDEED#
@80V
CCGCTTAATCAGACCCATCTCCATATCCACTGTGAGTGAGACAGGCATAGTTCAGGCCTTCAGGCTTGCCAGAAGGGCAGTAAGCCACTTGTTTTTCTTGN
+
@@@DDDDDFFHB>BHH=@CCHG>FHHIGECGGBFB@?CFDGGBFHB??3?BF@BF@DHGGC>@FGGIGHE@?EA;?=BEC;>@@CCCCCAC@@CCB>CCC#
@80W
TAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGGAAGCTTTGGCTGGCCGCACTGCN
+
@@@DDDD?H:?CFGEIGE?DFC9EG+2:E>:??EBEB4DDHICC>C9?DB0B??D<.=CFGBG)7CHC=7;=D>9BB&590<@AC:>4(<9?B905>.>:#
@80X
CTGAGTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACN
+
@@@FFDDEHHFHHIJGIIJGIIGICFGIIIHHIGIIGHIIIGJIIIGGGHFGJGGIIHHHGEGFFBCEDDBDBCCCCDBDBDDC:@AB@CDDDDEEE>CC#
@80Y
CTGGTGTTGGCGCTGTCGGAGAGCAGCTCCAGGAGGAATTGCCACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGG
+
@@@FBDDDHFHAFIGJJJJEHHFHGJIGIJIGIHIIIIIJEGFEGGGGJIIHHHFCE@BDCDDDDCACBCBBDC>ADDCB9>@DC@CDCCDB@BDDDDD
@80Z
CCTTGATGTTCAACCGCTGCTGTGGTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCCGCTCCAAAACACGACCN
+
?@;BDFFFCFDDHGGIHIJFIEFHGIIGGHEAFC>GHCGIGGIGDCEHGIJIIJIIEIGHHHDFFEFFFDDBBBDDDCBDDB9@DBDBBDDDDDBBD>BB#
@810
GCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIHHIJIJHHHHHFFFCEFEEEEDEEDDEDEDDDDDDDD#
@811
CTCTGATCATAACTAGTCGGGTGTGTTAAGGAATAGCTGGTAGGAGTGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGGAACACCCAGGTACCTGGGN
+
????D4BD::=CAE4:<+<<)3@1:1**1*****:*?B9B9*9?3*)008BDB>BC=2(((7@)==7?>)(..(((66=??'3'((+()((24(44>><<#
@812
CTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTC
+
CCCFFFDDHHFHHJJJJJGIIJHIIIIFGGGGHIJJJJJJJIGJIIIJJIGIJJHHHHFHFFFFFFEEEEEEDDDDDDDDDDAA?BBD@DDD@DB@>CC
@813
ATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTN
+
@C@FFFFFHHHHHJHIJJJJJJJJJJJJJJJJJJJJJIJJIJJHIJJIIJJJHIJJJIJJJIJJGHHHFFFFEDEDEDDDDDDDDDDEDDDDDDDDDDDA#
@814
GTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATGCGGCTCCAAAGAAGCTGGAGGAAGTGACAGGCN
+
@@CFFFADFDHHHJJJHFDABDDDD8?BDDD37?CEEDEDDDDD:BDBDD8BDBCDDD>CDDC@CDEDDDDBBDDDCDDDDCDDDDDDCDDDDDDDDDDD#
@815
CTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCN
+
?@@AD?DDHHHDHIIIIGII>H@HHCGHIIHBEGG@EHGHHAGHHGGIIIGDGGGGIEEHIGG@CFHFHGGCHGGH@DEHHHHFEEEDE@>@A@CCDCDC#
@816
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
;?@D;:ABAF<4DGGAGEFICCBAGF;?CEAFFFFCBFEFFEAEGAGIIDFFBBF@FEGIG>CEC;.;8:AEF7?>?B@;@DAC@>A;5;?=@==?B=@0#
@817
CACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTN
+
CCCFFFFFHHHHHIJIJJJJIIJIIIIJJJJJIGIJJJIIJJJJDDDDDDDDDDCDDCDDDEDDDD@CDDBDDBDDDDDDEDDDDDD@CDCDACDDDDD9#
@818
GGTGGTACTTCAAAATAGGTTGGCACAAAACAAAACGTGACATTTGGTCTCTGGTTTGTGAAGGAGCCATTGCCTCTCTCTCCTCCACGGTCTTAGGGATN
+
BB?DFDDFHHHHHJJJJJJGGJJJJJJJIJIJJJJJJFHIJJJJJJJHHIIJJJHIJEHGHIIGIGIHHHHHFFFFFEEEEEEDDDDDDD?BDDEDDDDD#
@819
GCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCN
+
@@@:DDDDHHFDA?FFIIB@HHEGAAFHBGCG6GH<:DGGIC@BFDGH@DDFG?2;CAEBEHB7?62?AAA@>@@??B>A?,5<?@C89?A?3>>C>(:3#
@81A
CCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTAGGTCCTTN
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJHIGIIIGJIJJIJJIJIJJJJJIJJJJJJJJJJGIJJJJJJJJJJHHHFHHGFFFFFEEECCEDD#
@81B
GGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCN
+
@@@FFDDADHCDCF>HDDHGEFEHEHGFDHHHIGHHFDHHIIIGIIDHEGHHFEEHFFEDDCEEEAECA;ACCCCACCC>>C<@>:C>CCCBC@CC>>A:#
@81C
TTTTCTTTGTCGAAACTGGACAAGCTTGGCTTTGCCGGCCTCCAGCTTCTTCTGTCTCTCCTCGTCCTCCATGGCCTCTGCAAGGAAGGCAGGGGAAAACN
+
CCCFFFFFGFHF=GHIJJJIGHIJGDGEGHIGGGHGIBHBGHIE@FEHGIIJJHAEGIIJGEHHFFFCDDECECDDD?CCACDDBACDDD@?BD>BDDD?#
@81D
GTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGN
+
CBCFFFFFHHHHHJJJHHHHJJIIJIJJJJJIJJIGIIJJJJGIIJIJJJIIIIDDDDCDDDCD>CCCDDEECDDDCCDDABDDDDBCDDDDD@@CDDDD#
@81E
CTTGGCATGTGGGTGGAAGGGTTTCTTTGGAAGACCCCAGTGTGGAATCACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCACAGATCACTGGGATGN
+
CCCFFFFFHHGHGFFIJJJJJFHIIJJJJIJJJJJJJJJIHIIHIJIJJJJJJJJJJJJJJIHHHHHFFFFDEEEEDDDDDDDDDDDDDDDCDDDDDDDD#
@81F
GCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
@<@DDBD208<C=C@<CCHCFFHDFFAG:CFCBFEBFC?GEEGF@F?BFFDFDF@A@F@EFA@?EEDBD?;@6>>@ABBBBB?=>55<9@ABBB:>@@B>#
@81G
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@BCFFFFFHHHHHJJJJJJIJJJIIIJJJJIJJJJJJIIJJJJJJJIJJJJJJJJIIJJJJJIIJIJGHHHHFFEDDFFDDD9@BD=CDDECD@ABDDDD#
@81H
GCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJIIJJJJJJJJJFGHIJJJJJJJJJHCEHHHHFFFFFFEEEEEEDDDDCDDDDDDB#
@81I
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
@C@DFFFFHHHGDBGHJDGHGEGGIGGGIIJIIGIIGGEGHIFEHIFHIGEHJGHIIGEIIIJIGEGGDCBEHFFAC>BEEAB?A@C>CDCD<@CD>ABD#
@81J
CGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCN
+
@<@DDDD>FDBHBBGGBHGDE+<9CBFEEAAFIGGICHDACEFFF@DGGEHGHGIII8;@AEH=B;;@>>>C;;>CC?;?B,55>>>@@CC@C@<A@3>@#
@81K
CGCCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGN
+
@@@FDFFDHHHFHJJJGGIGIGHHFGIGGDEHGDGHIJJHEGHBGFHIIEIIJJBFGHIJJJIHIIJGJIJIFHHHHEDDEFFDDEEECCDEECBDDDDD#
@81L
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTN
+
@@@ADDA<AF><CCFF<FGE?9EH@DE;EFIBEC@BDFDEEFBD>FF<FFIFFFEEEEFFFED?@DD@C9>;A@;>@?@7,5:>>AB@B@BBBBB@@BB@#
@81M
CTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGN
+
@@@DDABD8FHHHIIGGFDGHEF:FH)?FCABFI7;?;DDB=AAEH<=?.=?3?<,;3@AA3>5-;>C>;>CB<C>A:CC>@>@:@>C4>C?9?.<AAAB#
@81N
TCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCAAGCT
+
:?+4=@@DBBFDFBCAFHCEDC?CCBDH@G???BGBBD@D@FCC@@;4@AGEHHHA?BBC>C>BBC@>>C@??>:?@@@C>@?@A?C@:4@8?BB??B@
@81O
TCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
@@<B;ADD=FHACBBGBF@?C<HFDGHEC?F@H@E?:GG@?B?DD>GII;BB?BFEBHGCHHH:E?>CA@DDE@CC;?;@C;@CC@@?A?87>>@BB?0
@81P
CGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGN
+
CCCFFFFFHHHHHJHIJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJJJIJHHHHHHGFFFFFFEEEEEDDDDDDDDDDDDDDDDDD3<B#
@81Q
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
@C@DFFFFHHHHHJHIJFHIHIJJJJJJJJJJJJJIJIJJJIJJJJJJJIJJJIJJJJJJJIJJJIJIHHHFDDDDDDDDDDD@CDCDDEEDDDDCCDD
@81R
ATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCN
+
@C@FFEEFHHHHHJJJJJJHIJJJJJJJJJIJJJJJJJJJIJJJJJJJJJJIJIIJGJJIJJIJJGIIJDHHF;BBDCCEDDDD?BDDDCDDDDDDDDDD#
@81S
GGATGATTGACTTGGCGTGTAAGTAATCCATGCCCTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATCATCTCAAATTTGGTCTCAATGATATGG
+
CCCFFFFFHHHHHJJJJIJIIJJIIJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJIJJJJJIHHHHHHFFFFFFEEEDEEEDEFDD
@81T
AAAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTA
+
CCCFFDFFDHFDBH@GGGIIIGHIEEEFHJIJJADHGGGGGDBFHFGGIFEFGGEHGGAHIEG@DHIIIHGCEFAECE?CB?BEECA8;<ACECD@<B?
@81U
CCCTGGTCTGTGTAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCTAAGATGTCCACTGCTGTTCCTTCATACACACCTCN
+
<??D;:D?DDD?,<222+AF;F4AC+A4222A+*1@??9C*?D*1*0?49???*99<<D@@?*B.BC8).8))8)/@.@)7?=CC=)))7)7?AA('5;;#
@81V
GTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCC
+
CCCFFFFFFHHHFHHIEHJJGIIIIIJICGGGGIJHIIJIHIIIJJJJJIHIIIJJIJII@DEGHHFFACCDEDDBDD@BCCC
@81W
CTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTN
+
BC@FDFFFHHHHHHJJIJJIJJJJJIJJEHHJHHJJ8DFHHIJJJJIFHIJJHJJJJJHHGHFFFFFDDABBDDDDDDDDCCDDDDDDDDDDDDDDDEDE#
@81X
CATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTN
+
BCBFFFFFHHHHHJJJJJJJJIIJJIJJJJJHJJJJJJJJJIHIJJJJJJJJJJJJCFHJJIJJJIJJJJJGHHHHHFDFFDDDDACCEDDDDDDDDDDD#
@81Y
GTTGGCACAAAACAAAACGTGACATTTGGTCTCTGGTTTGTGAAGGAGCCATTGCCTCTCTCTCCTCCACGGTCTTAGGGATCCCAAGGAAGAGAAGTG
+
CCCFFFFFHHHHHJJJJJJHGJJJJJJJJHIJJJJJIJJJIJJJIIJJJJJJJJJJJJJIJJJJJJJHGHHFBFDEEEEDDDDDDDDDDDDDDDDDD@C
@81Z
CATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTN
+
CCCFFFFFHHGHHIJJJJJJJJJJAHHIIJHHIJJJJIIIJJJJJJJIJJJJIJHHIJFIIIJJGIIIGEHIHHHHHHF?C?CEEEEDDDDDDDDDDEDE#
@820
GCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACC
+
@?@FFFADFDFHHIGGBGIICDIIIGIIIIBAFCGGFGGIIIIGDHHGIIIDHIIIFGIEEHFFFFEFFCCCECECCC>CDDCCDECCDDCCCCCCCB>
@821
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
@??DBDBDFF?CB>BCGF@A<<?@):C:??BF0*?@DBFDFEBFFEFEFFF@@B:A1?>D@7;A>A3;;>A@>5(;;5;>:A:>535(38>??>@7+44>#
@822
CCTGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTN
+
??+A4BDEHFHGFIIIIFGHIIIIIGGIIGIIIDGGEIGIIIIDHFCB>BBCCBCBCCCDCDCCCCCCCBCCCCC5@BCCCCCCCCACCCCCCACCCCAC#
@823
GGGGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATN
+
CCCFFFDFHHHHHJJJIIJJJIJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJGHGFFFFFFEDCCEDDEDDDDDDDD>ACDEDDDDDDDE#
@824
CATGACTTGGTTTTCTGTTTGCACCACTTCCATTGGTTATACAGGACATGGGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFEDDDDDDDDDDDDDDDDDDDDDDEDDD#
@825
TGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCN
+
CCCFFFFFHHHHHJCC<AACGIHIJIIJJJJJIJJJIJJIJJGGEGHIGHHJIIHJJJJJIHJJJJIHHHHGHHDFFFFDDEDDDDDBDDBCCCDCDCDC#
@826
CTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATA
+
@@CFFDDDFFHHHJJJJJJJJJJJIJHIIFHIJJJJJJIIJJJIJIJJJJIIJJJJJIJJIJJHHHFFFFACEDEEDDDDDDDDDDCDDDCDACDCDDE
@827
AATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGAT
+
=@+=BDDEGFHHHJEHIJIIGJIIIJIIJJJJJJIGIHGGEFGGICEHEIIIIEHIIIIJJIGIGGHG?AHHHFFCFFFECEEDEEEDDDDDACB>A
@828
AGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGGATAGGTGCCTCCGGGCCAAGGCTTTGTAACAGATCGGAAGACACACGTTGACAGTCACCGATGN
+
@@@FDDDDDABFDHAFGGIIGCCHDHHGGGGGIIIGI@DHCEBBDGFDFDDFGHIIIAEH>EHFFFFFFF>;;A??B=?CCCBB??B<CCC4>4>CB@9B#
@829
GCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATN
+
@@@FFFFDHFBHFGGGHGGEGHIJHIGHDEHEGCHHI?DGGIJEDFGIIJGIGCAD>FGIGIJJFIJHGGHFF;AB8?B@B:@CDDFCACC:>>:8?):C#
@82A
CTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATTAACTGTN
+
CCCFFFFFHHFHHJJJJJJJJJJJIIHHIJIJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIJJJIGHHHHHGHFFFFFFE#
@82B
CTTGTGCAGAATGCGCTTGTTATAGTAATAGCGCAGGGCCCGGCTCAGCTTGTCGTAATTCATCTGGGGCTTGCACTTGCGAACGCCCCACAGCCGGGCCN
+
@@<D;?AD8A??24@EFGAF@@4AB2<C4?ED)8C)0)?D<G8/;;@@7CEE?A4,66=@C6>ACCCC@>B22(,>@35@9<5<&5<BB25??B?BB<BB#
@82C
CTTAATAAATTTGTAGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCATCTGCTGTGGTTGAAATTTCACTTTCCAGTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJHJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJIIIJJJJJJJJHIJHHHHFFFFFFFEEEEEEEDDD#
@82D
TTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGCGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCN
+
;??DDDABDBDDDA;1CE?+::<C3CF;;:1?DD@@DCCDDA)06;@AACE9?C;AC@>>>9>>>8(8(5<?AA3<>AAAAA>AA><5>9>--;2825;&#
@82E
CTCGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
@??DDBD;<C<FBFC>AF1?8CHH9CE1:?FGDD3BGHIICC(?;1B8BFHIG@=C3@@/C?7AA:;B?6>B@?-5(;5-5@>ADC5<35>@CCCCAC
@82F
TAATAGCGGAGTGAACGGCTAAGTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTA
+
CCCFFFFFHHHHHJJJJJJJJJJIIJJJJJJJJJJJJJJIJJJGIJJJJJJJJJJJJJIIJJHHHFFFFDDDDDDDDDDDDDDEDDDDDDDDDDDEEEE
@82G
AGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCN
+
@@?DDDFDDDDHFJJIJIGHIIIIGGHIJIIGIEGGIIIIIJJJJGEIEGHIGIJJIJIIJGJJIJHHGBDFCEEDDCCEDDD@CDD@?@@ACCCEDDDD#
@82H
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
@@@D;?DBA8<?DGHC@AAEF;CHG@HHEDHGCGGB<CF9?60?89?FD?DDHI@BG<BFC>CHH@GA@>@DD@AEEA;>?B.493(;?A>;;@>@>>@C#
@82I
TCCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJJJJJJJHHHHHHHFFDFFEDEE#
@82J
CCGCCTTTAGCACAGTGATTTCATCTTCTTGTTGCTGAACTCGTGACTCAAGAGCTGACAGGCGATCTTGAACATCAGAAGTACTTGCAGCAGAAATACTN
+
CCCFFFFFHHHHHJJHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJHIIHHHHHHFFFFFEEECCEEFDDDDDDDDDDDDDD#
@82K
GGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGT
+
BCBFFFFFHHHHHJJJJJJJJJJJJJJJJJJIGIJIGIIIJIJGIGIEICFHGGICHGIIAHIIHGEHEHHEEFFFDEDDDDDDD,;@8@@9@CCCDC
@82L
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
CCCFFFFFHHHHHIIGIJJHIIIJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJIIIJGIIJIHJJJJJHHHHFDFFFEDEEEEDDDDDDDDD>CDDDD
@82M
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
CCCFFFFFBFHHHJGIJJIGGHIIIIHIJJGGJJJJJIIIIDHIFIFIIIIJJJHIJGHJIJHHGHEGIFH9>AB;CCDEDDCDDDDDBDABDDCDDDDD#
@82N
GAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACN
+
C@CADDEFBHFDHIIGIGIEBFHGHHIIIIIIIHGG?CFEDGFGGIIIGIEEHGBFIGIGIIIGHEHHHF=9;>AECBBBBCCCCCC@98?BA?BBCCCC#
@82O
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCN
+
?@<DD?DD=DHDFIGGGA@?AB?CFBGI?HCGEHBHIECDGBBFF@@?B?DBBGB99;FBFHC;===;6AAE>;.777?;ADAACC@C:3>ADCCC5??@#
@82P
CCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGN
+
CCCFFFFFHHHHHIJJJJJJJJJJDGGGHJJJJJJJJJJJJJJJJJJJJJJJJJHHHFFFFFFEEEEEEDDDDDDDEEEDDDDDDDDDDDDDDDDDBDDD#
@82Q
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
BCBFFFFFHHHHHJGHJGHIFHIIJJJJJJJJJJHHIIJJJJJJJJIJIIJJJJJJJJIJJGIIIIJIHHHFDBDDDCDDDCDACDCCDDEDDDDCDDD
@82R
GGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCAT
+
CCCFFFFFHHHHHJICGHIHHIIJJJHHIJIJJJJJJJGJJJJJJJJJJIJJJHHHHHFFFFFFEEEEEEDDDDDDDDDEDDDDDDDDDDDDDDDDDD
@82S
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJIJJJJJJJJJJIJJJJJJJIJJJJJJJJJJJJJJHHH=AD>CDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@82T
TTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAA
+
CCCFFFFFHHHHHJJJJJJJJJJGJJJIIIJBHIJIJJJJJJJJJIIIGGIJIGHHHIJJJIJJJGIJJIJJIJJJJJIIIGFHHGFFFDFFFEEECEE
@82U
CATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGGCTCAGACATCTGGCGTTGGTACATAGGACGTCCTTCCCTTGGN
+
@@@DD;?DD3?FDH8EFBEBC>FHGFIFCE>B?DDH?:BG?DGGEHGGG:';;EEHCEA>BC@@DBAACCCCB>=?B,5ACCDCCC:<>B(8>@>9@@?3#
@82V
GCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTG
+
CCCFFFFFHHHGHJJJJJJFHIJJJJJJJJJJJJIJIIJIJJJJJJJJJHHIJJJIJJIJJJJIJJJJJJJIJIHHHHH;@CAEEDCDDEEDDDEEDD
@82W
CCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
CCCFFFFFHHGHDIGIIJJJIHFHIGHIJIJJGHGIJJJGIJJJIIJIJG:FEHIGDDDDDDDDDDDDDDDDDDBBDDDBDEDDDDDDDDCCCDDEDDD
@82X
TAGGAGGGGAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGN
+
@<<D<DAD0)@D?>BFBGF?B<CD<DD99BA@FGFF@DECF--@;@@ECADE;A>E>BBDC=>?A>;A3;>(;@:5::>>>:;>B>>>>>@A<:<BB8<@#
@82Y
GGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGCTAAGTTTAGAGGCCA
+
CCCFFFFFHHGHHGIGIIIIJIGAFHIJJJJJGJJJJJIIIIIFIIIJ=FEHIIIIIDHJGFDFBEEEEDDDDDDDDDCDBBDDCCEEEDCCDBDDD
@82Z
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
CC@FFFFFHGHHHJJIIIJJJJGIJ@FHJDGGIJJJGIIJIJJJJIGIJIJJHGFHHGFFFFFEDEEDEDDDDDCDEDDDDDDDDCDDDDDDDDCC@>@>#
@830
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATN
+
@@?BDDDDHHA=A>EGBGG:CBHHFHFGGII>BDGCCD@GHGHIGGGGGECGI@AGG;CEEECE;>@B2;AABBBCACB<CCCC@@CCCACCAC<>>ACC#
@831
CCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTGATAGACGTAATCCCAAAGCAGTCTACAGTCTN
+
@@@DDFDFHHHGFIHEDHHIEEFHEHHFEFBBBD;FFEBGHIJGH<?;FHB@BHIEEGE>>ECD>CFECCCAA>A?BAA<CCCCA<5?>9@CAACCCD@A#
@832
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
CCCFFFFFHHHHHJJJIJJJJIJJJHJJJJJJJJJJJJJEHIJJIJJJCHHIHIJJJJJDHHHHHFFFFFFDEDDDDDDDD@BDDDDDDDDDCDDDDDDD#
@833
GTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTGATGTCCGCAAACN
+
@B@FFEFFHHHFHIJJHHIIJJJJIJGHIJJIIJJDIIIJFHIJJJGIJHIJIIJHHHHHFFFFFFDEEEEEECDDDDDCDDDDDDDDDDDDCDDDDDDD#
@834
TTCCAGTTGTGCCCGTAGCTTCCTTGAGGTCATTTTCCACTTTCTCCTCTGTCACTAGATATCGTGCGTAAGATATTTATCCTTGATTTGGAAAAGCCT
+
@CBFFFFFHHHHHJJJJJJJJJJJJJJJJGHIJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHJJIIHHHHHFFFFFFFDEEEDEEEDDDDDDDDDD
@835
CGGGTGGGACTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTN
+
?@@FADDFFDHHHJJJIIJJJJJJIIIIDGEIJIJJJIJJJJJGIFIHHFHFFFEEECEDD?CDDDDDDDDDD:?B@BBDDDEDDDDD@CDBDDDDDDDD#
@836
GCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTN
+
@C@FFFFFFFHHFHIJJIJCFHIJIIIJEEGIGHGDFHBFIIGHIIGHJIIJEEGHIG>FHIIJGGGBCEEEFFFFDDDDD@CCCDCDDEDACCDDDDDC#
@837
CCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCN
+
C@CFDFFFHHHHHIIGHIIIHJHIJIJJJJIIJJJJJJHJJJJJJIGIJJIIJJJIIIIJJIHHGGHHDFFFBEDFFEDEEDDDEEEEDDCDCEEFEDDD#
@838
CTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGGTACACTGCAGGTGGGTGGTCAGCTGCAACATGGCCTGGCN
+
BBCFDDFFHGHFBHJJJJJJJJJJJIJJJJIIGCFHIJJJGGIJIIJJIIIJJJIIJJJJDDDDDDDDDDDD9CBD<BDBCDCDDDDCCDDDDDDDDDDD#
@839
GTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGC
+
=??DDDABFDD?C><<CAAEHGIHGEH?CHG=AH?:DGHGIDEGGICHHHGIGHGGIBD@@F@@)=@CHHB37@D6=A>@ABBCCC:>C>ABBCCC:4
@83A
GGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGAATTTGTGGACTTTGN
+
B@CBDFFFHHHHHJJJJJJJJJJJJJJJHIGHIJIJJJIIGHIJJJJHJIIJGHIHH)BFHIJJJHHHFFDDCDDD>CDDDDDDDDDDDDDCDDCDDDDD#
@83B
CTTGTTTTTCTTGGCAGAAATCTTTGTCTGCATGTGGTTTCTTCTCTTCTTTCCTAAGACCACAAGATTCAGATTCCTGGGATCCTAGAGGACCCTC
+
1??D+2A?1AB4AEACEEAEEEDEEB9BFA9C*:?C3?C)*:?*:?9<*0*??*9*0*9*))(8==A@CA;;47=)?=CC=6)5@)((6((,;(=(5
@83C
ACCCACTCCATCGAGATTTCTCTGTAGCTAGACCAAAATCACCTATTTTTACTGTGAGGCCTTCATGAAGAAATATATTATTACTCTTGAGGTCTCTGTGN
+
????4BDD;?<:C:BA1<::3C@H<9+2<A?:4?3CB;<?@3BDGFF@FF9BF*0/8BC(-@73=4@@C:D=CCEC7;7=;AB;@:7;(63(6=A>@A35#
@83D
GGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATN
+
CCCFFFFFHHHHHHHHIIJJGIJIJJJJIJJIIGHIJJIIJIIJJJJJJJJJJJJJJJJJJIJIIJIIJJJHHFGEFFFFDDEEEDCCBCCCDD@CCDDD#
@83E
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
@C<DFDEFFADFFHIIG@EAGCHIDIIGGDEFGIIIGGDF@BGAF<0BDFHGE@BAGHHIBHA@?CEHFCCFBCB=CEADDECC@ACCDEDCCCCCCA@
@83F
AAAGGGCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTA
+
@@@FF?DDHHHHDGGIIIJJJJIIJIIGGEHGGDGGHFIJJJIIIIIIJIIIJIIJIJEHIIGHGHGHJIJIHFFHHHHHFDFFFDBD=ACEDDDBDD
@83G
CCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGCGGTAGGCAGAGGTGGTGN
+
?@@A?8DBF8F1)@?8EG@??FA993DD;(8(.BB5).7.=C).).7====3)..9,;=AAB;-55((95:55>::22+(8<()-995+>42<<8+22&8#
@83H
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCN
+
<?@?DEA?DDFFFGHEGGGGIIIIIIIGCAHGIGEHEDGBHGEEGI@GDBDEHBHIIGCHGGIECGHEA=?CDC;>><AAA@BB=?@=BB>@A@@A>@CA#
@83I
GTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGCATTCTTN
+
CCCFFFFFHHHHHJJJJJJJHJJJJIJJJJJJJJJIJIJJJJIJJJJJIJJJJJJJJJJJJJJJJJJGIJJIJJJJJHHHHHHHFFFFFFDDEDDDDDDE#
@83J
CACAGTCGAGCCAGTCCGTTGGGATCCACTATCCGGAATATTTTGGATTCTTTGTCCTCCCATCGGATGAAGTTTTCGTACCGGCTGTCAGAAAGCAACTN
+
CCCFFFDDHHGHHIGIJJJJJIJGICHGIJIJCHIJIIEGIIJJIGBHHHIIIIGGIIJIHHHHFFECDEDDCDEDCDADDBDDDD>BDCCDDDDDDDDD#
@83K
GGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGTGGTGGGAAGGGGATGTTTGN
+
@CCFDDFFHFBHHJIJJJGHIIGHIIGIIJGCHIDGDHHFHHHIGIJIJIIJEHDHHBBBBCEDCCCCCDDDDDDDDDDDCDB9?BDACBDDDB>@DDDD#
@83L
TAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCN
+
@@@BDDDDHHFHHGGIJJJJJHIIEHGEFDEHIGIIIEHBFGHEAGC@GGGIIHCEEB@D@D>CCEECD;ACC;@CA@@CCCCAC<BAAB>@@(44@@CC#
@83M
CGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAAAGATTTAACTTCTTCATTTAGAAAACTAATCTCN
+
BCBDFDFFHHHHHJJIIJIJJJJIEHGJJIHJIGIJJJJJJJJJJJJJHFHEIIJIIHIJJJJJJJJJJIJJJJJJJJJJJJJJHHHHHGFDFFFFCECC#
@83N
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CBCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIJJJIJJJJJJJJJJIIJHHHHHFFFFFFFDDD8?BDDDDDEDDCDDDDDD#
@83O
TTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTCATCATAGTTGTCAACATCGGAAGGAATGAACATGGTN
+
CCCFFFFFGHHHGJJIJGIJJJJJJIJJJJJJJJJJIJJJJJIIJIJJIHHJJJJIJJJJJIJJJJJIJHHHHHHHFFFDFEDDDDDDDDDDDDDDDDD>#
@83P
GCAGGCGGCAAAGACTAGTATGGCAATAGGCACAATATTGGCTAAGAGGGAGTGGGTGTTGAGGGTTATGAGAGTAGCTATAATGAACAGCGATAGTATTN
+
@@@DDFDDDDHHHGIIGIBFGHGJIGGGEGAGDADCCFFFI@CCAHEDGI/=-=BEBA>AB@AAB5<ACDCC:@5:A@CD@DDECCCA@CBBBBBD@CCD#
@83Q
AAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCC
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHHFFFFFFDD@BDDFEDDDDDDDDDDDDDDDDDD
@83R
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGN
+
CCCFFFFFGHHHHJJJJJJJJFHJIJJHHIJJIJJIIGJJJJGGIJJJHGGIEGJIJGHGHFFFDDDDDDDDDDDDDDDC>CDDDCB?CDEEEDDDDCDD#
@83S
GGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGN
+
@@@DDD:?DFDFFIEEG@:<:<::A:FG;CDEBGGBEFCGCE@)??0B??/BD99C<=CDFGCEFGIE1@:8;9<@22;AAB:@3>?4@@>A>3884>:5#
@83T
CATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGN
+
@@@DD?D;CAHDHGEGF@?2<AAA?9?BGBGHB*B:B;BG>F;?DDBHFH>F@FAD;@;=E8=CDE>3?CCCC>66;@C=AC@CCC:>>>@@>5358@:<#
@83U
GTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGN
+
@C<DFF>DH?C<CGBDBDHIGEBDCAA<?AA:E?C?@G@@G>D@FAHEBBFB?BDFHIBAA;7))8@@@9<?CA<<><4@C3?894443@?C3:::A>2<#
@83V
TTGTCTCCTTTTCCTGTATTTCTTCTTTATTTGAGTTTTCTACTTTTTTATCTTGTTCCATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGN
+
@CCFFFFFHHGHHJJGCHJIJIIIIIIIJJJJIJJHHIJIJJJJJJGJIIJJJJJHIJJIJJJJIJGIIJJJJIGIJJJJGGIJEEHHHFFFFFCEEEED#
@83W
CTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATN
+
@C@FFFFFGHHHHGEGGEHIGIGCHIIIGHGHJGHGHJIIJJBFGGCGHIIIJIIHIICHFHIAAGHIEGHFH?EHBEFFFEECEEEFDF@CCCBDEDCD#
@83X
TCCTGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTN
+
CCCFFFFFHGHFHJGIBGHGGIIIIJJJIIIIHHHGGIIGHIIIJIIIJJJJJJJJIIHIIJJHH=BC9@CDDCCDDDDDADDDCDCDDDDCDDD@DDBC#
@83Y
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFDFHHHGHIEHHGIIJIJIIJJJJJJIIIIIIIIGIJJJIGIJIEIGJIJGGGHHFGFFBD39?BCDDD@CDDDDDCCDDCDDDDCCCDBB>@DB#
@83Z
CGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCN
+
@<@?=860918A38383>3>BDDB>@BB338<887<?8?>83@BB@A>AA>>99A:@A>@B0053:3<@>3@@(4(1:4:AB:>:?B@>9???<3(:44@#
@840
AGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGG
+
@@@FBBEFHHHDHGHDHBGIGIAHGIIIEGHIEEHIIGCDGE;FGHIIHFBDCBD@CC;;CCCC>;A;@CCCC9A??AAAACA@CCCCCCBBBBB?BCC
@841
GGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGG
+
?@=DDFDDHHHHGJIIIHGIFFHIJIJJJIIJJGIIJJJJIJJIJIIJJGGIIIGIJIIIIIGIIIGIHHGFDD@BDDDDDCCCCDDCDDEDDCDDDDD
@842
CTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGT
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJJJHIJGJJJJJIIJJJJJJJJIJJJJJJIJJJJHHHHHFFFEDEEEDDDDDDDDDDDDDDDDDC
@843
CTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATGAGAGAGGGTGATGGGCTTCCN
+
@CCFFFFBFBFF;GFBG@GGGIIGIGBHGGGGEBC<6=C=>AC???A:5;>B99<8A>CA>>C>A9?<A+4>@>A<000<>:>>(+8&+81:@CBBCBCC#
@844
CCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCAGGATCAGAGGGTGCATGATGGGGCTGGGCATCAGCTGGATCACGCGTGN
+
CC@FFFFFHHDFFGIIIGGEHIGHIIGGHGECGHIJ@GH?DFHFGGID=@BCCDCCCDCCCBB2<<ACC@CDDD?>>@B?@?CADDDDCCDADDDBBDBB#
@845
CATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTN
+
CCCFFFFFHHHHHJJJJIHIJJJJJJJJJIIJJ?GHIHHJJ7DGIJJJJJJJFHIJJEHHHHHHFFFFEEEEDD?BDDDDDDCDDCDDDDDDDDDDDDDD#
@846
CTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGN
+
CCCFFFFFHHHHHJJJJJIIIJJJJ@HHJHIJJJJJIJJIJJJJIJJJJJJJHHHHHHFFFFFDEEEDEDDDDDDDEDDDDDDDDDDDDEDDDDDDDDDD#
@847
TAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTN
+
CCCFFFFFHHHHHJGHHIIIJJJJJJJJJJJGHHIHIJJBGIJIJJJIJJ@FGJJIJJJHHHHHFFFFEEDD@BBDDDDDDDDDDDDDDDDDDDDDDDDD#
@848
GCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCA
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJHHFFFFFEDEDDDDDDDDDDDDDDEEDDDDDDDBDDDDDDD
@849
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGN
+
@@@DDDDDFBB?F:CFH@EAB4<FH@BBEHHIGGDBGGEGIIGHFDGEGCBCHGICHHICGHD7@BE5=CEEEEE;AC5;@3>5;:>CCBB<BBCCCBB<#
@84A
CCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTCCTGGTTCCCCTTCTAGGCAAAGTGCTTCCN
+
@@@DDDB;FFHBFBGBFF@?FH@B9A9AFAC98:CEA9?@D@@DGIEFGFE9?8B*@;:B<..8=@AAADEC:;AED@:??@A.;@CA9;??3:>@CC>>#
@84B
GTTCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGN
+
@@@DFDEFHHFHHIJJGHIGIHIIJIIHIIIHIJJGHIGHIGHICFHIJJIHIEGGHIIGIJIGGJGIJJJIGGGGJGFEEEFHEFDCFE@CEEDDCCC@#
@84C
CCCCCTTCCACGGCCGGCCCTCTAGGGACTCGAACAGAGATCTCTGCAGCTGTGGGTTTCTTTGCAGCCTTGCCAGAGGAGGTGGTAGGCAGAGGTGGTGN
+
C@CFFFFDHHHFFGIFGHIJJJIHIJJJIJEEHGCIJJJJEEGIIHCFHHFF?CDC=ABDCDDACDACDDDCCDDCDDDDDD(8?9CCBC>?BBD(8?9B#
@84D
CTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCN
+
CCCFFFFFHHHHDHIJJIJJJJJJJJJJJJJIJJJIJJDGIJJJJIJJJJJJJJJJJJJHHHFFFFEDEDDDDDDDCDDDACDDEDDDCCDDDDDDEDED#
@84E
CCCTGCTTGTCATAGTCACAACTCCATCTAATAAAGAGCTTACTTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCT
+
CCCFFFFFHFFBFHGIIHIIIJJJGGIGIJIIJJJEIGIJIJJFHFGGBFGEIHIIIEGGHHHHGGIJJIHGGGIJJHIIHHHEFEFEEDDCCDEEED
@84F
TTTTAATTTATAAAACTCCACTAGGAAATCCATTTAATTTTTATGCATGTCCACAAAAATATTTTCTTTCTTAGGAATCAAACACTTTTATTGGAATAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJHHHHFFFFFFFEEEEEE
@84G
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJGGIIJJJJJJJJJJGHIJJJJJJJJIJJJJJJJJJJJJHHGFFEEEEDEEDDDDDDDDDDCDDDACDD#
@84H
GCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATN
+
CCCFFFFFHHHHGJJJJJJIJJJJIJJIJIJIIJJGJDGIJJJJJIJJJJJIIEIJIJJIIJJJIJJGHHHFF7>C>BDBDDDDDDFDDCDCDDC@D>CD#
@84I
CGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCN
+
CCCFFFFFHHGHHJJJJJJJJIIJIJJJJJJJJJJJJJJIJJJJIIJJIJJJJJJJJIIJJJJJGGJIHHHHHFFFFFFEEEEEEDDDDDDDDDDDDEFD#
@84J
CCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTAT
+
CCCFFFBDHHHHHJJJJJJJJJJJGHIEGHGHIJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJHHHFFFFDEEEEEDDDDDDDDDDDDDDDCDACDEEE
@84K
GGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCN
+
@CCFDDFFHHFHHGIFGHIIJJJJJJJJJJJIIJIIIIJJJJJJJIIJIIJJIIIGHGIIGIJIJJIHHHFHHFFDDCCDDDDACDDDDDDDDDDDDDDC#
@84L
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
@@@DDFFFGHHHHFFHIJJJJIJJJJJJJIJJIJIJIIIJJJJJIEHIIJIJEIGIGGHIJJF=BC>CCDDCDDDDDDDDCDCDDDDDDDDDDDDDBDCD#
@84M
TCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTN
+
@C@DDADEHGHFFHEHGGIGGHGIIGIIHIHCGEDGAFEHIGIIEHIIGGEHEEHHGGDBBFFCEECACD;?BD@?BD@CDDCCDDDDDCDDCDDDDCCD#
@84N
CTCGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCN
+
:?144@@ADHFABDECEA@@HHGBGIEEHIFD0?@F@=88CGE7=FIGIH=??B;CEEC@@AACC@;A>CCC5?>>CC>>CC>:>AC>@>:C:ACA>@A>#
@84O
CCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
C@@FFFFF?DFDBBGGHIICDFHIIFIIIGG??EFAGI>?CFH:DFGGGDA@FE<59>ACCCBBB?@BBBBCCCCB@B?@ADCAC?CCC>@>CCDCCC
@84P
TGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCN
+
@@CFFFFFHHHHHJJIJJGHHIFHGIIFIJIFGIIIHHIJJIIGHGFIJJIJJJJIIIJIHHHHBDDDFFEEDCBDBDCCACDDCDCCEDDDDD@CCDDD#
@84Q
CTTATCTTTAGCCTCCAATTATCTCCTACTTCAGTTTTGATTCTGTTTAGCCAATTTTCATCAAAATATGCAGGATCTATCTTTTGAAGAACCTGGGCC
+
??@DDADD?F++AA:CEC?C<FHI>@:AF<<22CCBGF)?DFCF9:BFF<B9?@BABBFG8DF<BBBFIGF>F;A7@.@CEEEAEEEDBB?@@>2.(5=
@84R
CTGCTCTGCCTTTCAGATGGAAGGCCGTTGCCTTGACCACTTTTCCAAATTCGCCTTCTCCTAGAGTTTTTCCAAGAACCAAGTTCTTCCGAGGGAATTCN
+
B@@FFFFFHGHHHJJJIIIIJJGIIJIJJJJJIJJIIJJJJJJIJJJI?DFHIJJJIJGIJJJJIHAAEHHFFFFDEEEDADDDDEEACDD?BBDDDDDD#
@84S
CGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATC
+
CCCFFFFFHHHHHJIIIJJJJJGHIJGJJJJJIJHHIIJJJJJJJJHIJJJJ@FHIHFABDDDDDDDDDDDDDDDDDDDDDDDEEDDDDDCDDDDDDED
@84T
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJJIHIIIJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJIJJHGGIGHHHHFFFFFFEECCEDCDDD<CDDDDDDDDD?BD
@84U
GGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGN
+
@@<BDDDBBFFDCGBGHIEHFFFEEFHHIHCGCHHIIGDGGGAHEGHGGG@CGEHHGH7?=??BDB?ABDC>5>>A@CDDDEDCDCBD509B<CCDDDDD#
@84V
GTAAAGGACCATAAAACGTTGCCATCCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTC
+
@BBFFFFFGHHHHEIJIFFFHIIHIIIJJJIGIJJIGJJJJJJJJFGHDHEIIGIIIGFHHHFFFFFDDEEEEDEDDACDACD@CDDCDDD@@BCDCD
@84W
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
CC@FFDFFHHHHHJJJJJJJIJJJIJJJJJJJJJJHHJJJJJJJJJJJIJJJJJJJJJJJJJJJJFGIHGHHHHHHFFFFFFFEEECEDDDDDDDDDD>B#
@84X
GTTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGT
+
CCCFFFFFHHHHHJJJJJGHIJJJJJJJJJJJJJJJJJJJIJJJJIJJJIJIJJJJIHHHHHHFFFF9@B?CDDDDDDDDDDDDDDDDDDDDDDDDDD
@84Y
AGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
??1;DDBDHDBD>GBGHGGGGHGGIIGBFGCGGHHEIGEDHEGGIGGFGIBHCEHIDHBCEAEHFD@DCCCC<@>;?3=;<:@AC4@?BBBBCACCACC>#
@84Z
AGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTTGATGTTTGAATAAGGTAACTGTCCAGTCATCAATTCATACAGAACAATTCCAAATGN
+
BB@DDFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJJJJJJFGIJJJJJJJJIJJJHHHHHHHFFFFFFEEEEEDDDEDDDD#
@850
GTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTN
+
;?@DDED?AFHHHJJJECIGGHEHHEGHG@FADHBDFGBGGICGGDECHGGH@ACCHEHIEFCEHHDEDFDDEEDE@CCD@DD9?5>ACCCCDCCDAC8C#
@851
TAATTTCTCTCGCTTGGTTACCTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJIIJJJJJJJJJJJJJJJJJIJJJJJJHHHHHHHFFFFFFFEEEEEEDDCDEDD#
@852
CCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGC
+
CCCFFFFDHHHHHJJJJJIJIJJJJJJJJIJJJJJJJCGHHIJJJJJJJJJJJJJJJJJIIJJJJJIIHD>@BDEDDDDDDCFDDDDDBDDDDBDDDD
@853
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
CCCFFFDEHHHHHJJJJJJJJIJJIJJJJJJJJJJJIGIIIJJJJJJJJIDIJJJJIJIJJJJJJI8@GEEHEEHFFFFDFFEEEEDECDDDDDDDDDD9#
@854
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
C@CDFFFBFHHHHIGHGIGGGGACHFH?FHIC9CCFGEGGGIIICG@BGGIIIEFEEEHGIBECEEFFFBCA>=6;>;AA@;@>>@>?CCCCCCCCCC
@855
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@@DDDFDDFDHHIIDIIFHGDCGIIJJJJIIIIFGDEHDHIIJGIIIIGIGDCEEHEEFFFFDECCCAEDCDDCDDCDDDCFDCCDDDCDDBDB@DDD
@856
CTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGN
+
@@;DDDBDHDBDHGHIGGHGGGCHFEBFFHEBGIBAFHEGHGHI?DBD@BGGGHGHHGB=FHEIHEIIGHFDFFFDDC:>>@>ACCACCCCCCCCECCCC#
@857
TCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTN
+
CCCFFFFFHGHHGIJIIIJJJIIJJJJHHIJJJJJJJJJJJJIIJJJJHHHHFFDDDEEDDDDDEDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDBDDD#
@858
GGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCCTTGGTGAGAGGN
+
@@@;BDDAHHFFFGIIGEGFG@FHII;FGHGGGHCEHGGBAHIEGGIHGC6@C9DEDDEHHEB5@DC6>>@ACBCB;>@BBB@@BCCC?CC?C48:8:>@#
@859
GGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTN
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJIIIGIJJIJIHHEFFFFFEEEEEEEDCDDDDDDDDDDDDDDDDDDDDD8AABDDDDDDDDDDDDDDBDDDDC#
@85A
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
@;;?;D=D=:2AC<:<EGIB13<8CFI39:D<1CGG9:9:0?9F99*09?B4D..=F8BF)=)8)>=D77>8'58666(6(62;5>555@B9,5,5@>50#
@85B
GCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGT
+
?@@DFFFFHGFHHJJJGIIIGJJIHIJIJJIGIIIGHJGGEFIGGIIGGEHBF==CFGEHEGGGGHG=CHHHGEEE>DFFFFEDEDEECDCDDBBB9?>
@85C
GTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCTCCTCTTGGGTTGGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCC
+
CCCFFFFDHHGHHIIIJJJJIIIIGEHGIJJIEIGGJJIIJIJJJGGIIGJJHE;CEEACHFFDDEFEEEEDDDDDDCCCDDDBBCDDCCABBBDDDD
@85D
ACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGC
+
=@1ADDEFHFHHHJJJJJJJJJJIJJJJJGIJJFHIIJFHJJ?GHIGEHIJJJIJJJJJIJIHHHHHFFFFFEEDECDDDD@CBDDDAB>ACDDDDDED
@85E
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
@@@FAEDDBCDDDBG<AF@G@G@CHHIIIBHB???F<:@GDGBFHI?BBGBBBBGHIIIIIC@CA?CC??DFA;6;A=8;>@CCCCCCBC<52@CCCCC
@85F
GTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAGAGTTTCTTTTCCTGCAATTGAGACAGCACTGGTATGACTTGGTTTTCTGTTTGCN
+
@@@FFDDFFHGHHIIBHIII>CFEGHIAEGH<GIEEDG@@?F<DFBGGHAGGHIGGIGIGGCECE@DGEHH>?DBEBBC:>ACCCCCCCBB@CCC>CA>>#
@85G
CTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATN
+
CCCFFFFFHHHHHJJJJJGIJI?FFHIJJIIIJJJJJIIJJJJIJJIHJIJJIIHFFDDEEDDDCDDDEDDDCCDDDDDDEDDDDDDDDDDDDBDDDDDD#
@85H
TGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJIHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIJJJIJJIIIJJHHHHHFFFFEEDEDDDDDDDDDDDD#
@85I
CCTGTAGGGTAAATGGATTTTTAAAAAAAATTCAGTTTATCAAATTTCATCTTCTCTGCCATTTTAGATTGGCAACTATTGGTTATTTAGAAAATTT
+
@<?DDDDAFAADFF9E<FH>@HI<FHFBFFIIBFFFGFC@FCE88DBBBFFIFE@FI4=DEEE>;AA;?E>BD7;?BACDCC@BBBBEB>AABBBBB
@85J
CTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGN
+
BB1ADEFFHHHHDHHIJJJJJJJJJJJJJJJJJJJGHJJJJHJJJJJJJJJJJJJJJJJJFIHIIJJHHHHHEFEFFFFDECCDDDD@DDEDDDDDDDDD#
@85K
GTCTCTAATCAAGTCCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGGGATGATTCCTTTGTTN
+
:?@DD;B?FFA<AFG??A3A<<<F4:AAFH92<2<999*11@?*11?****:FG?9F*9?D<9*///?<98-..//=4@FC@7.)6.=C;))7.;;.;@>#
@85L
CAGCATTGCAGCATCAGGCGGTACATCTCCTCGCTGCAGTTGTCTGGCCTCTCCATCCGGTGGCCGGTCTTCAGAAGGTTGAAGAGCCGCTCAGGAGGA
+
CCCFFFFFHHGHHJJJJIJJJIIIJIJGIJJJJIIJJJJHIJIJGGGHIIJIJJIHHHHFFD>ACBDDDDDDEDDDDDCDDDDDDDDDDDBDDDDDDDB
@85M
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
C@@FFFDDFHHHGJIJJFHIJJJIIIIJIJJJJGJJJJJIJJJIIJJJJIIJIIIIIJHHHHHFFF=@BBDDDDDDDDDDDDDDDDDDDDDDDDDB>@BD#
@85N
GCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTN
+
@@@DD?ADADHBBDB?BFGB@C?1?C;GHGEDG@DAGCHIFBHGHHEEH@@FCCB@CGEHGC@EHC=AEHFEEDEE@AB=@?BBCCCCC?3>BCCA@CCC#
@85O
CTTCTAGCTTCTTTTTATAAGATTCTACTTGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCN
+
8?@DBB;DFHBFBGHI=GIHHDHHFGHGGD@CGCHGHC?EFFHG@FCF@AFGIIGAHHHGAGHGHCGH=BFHDHFCHBHEAA?D?CDE@@CCCCCAC<;@#
@85P
CTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGT
+
CC@FFFFFHHHHHJJIJJJJJJIIJJHIJJJJJJJJJHHIIIJJJJJJJJJFHIJIIJJJJJJJJJJJJJJJHHHHFFDDCDDEDEDDDDDDDDDDD<
@85Q
CTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCC
+
BBBDFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJHHIJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHHFFFFFDEEEEDDD
@85R
TGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGA
+
=@@?B:D?A=<<C<AGEDGHIIAHFEHEG?B@9??F@DCAFB?B?BFC==<=;C@@AEA=@EH)7==7=?;CEDCCCCCCC@CC@AC?<?CBBB?B@50
@85S
CTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCN
+
CCCFFFFFHHHHHGIJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJIJJIJJJJJHHGHFFFFFDEEEEE#
@85T
CCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGN
+
CCCFFFFFHHHHHJJJJJGHJIJJJIJJJJJJIJJJJJJJIJIIJIJJJJJJJHHHHFFDDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@85U
CAATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATN
+
?<?DDDDDBDHBHIBBEHIBDEGB>FBGGEGHDGE>DDHGEGEHG@FHGGGGGDFBCCHGH7CA=DFGGHHFBEDDB5@C;B@CB;CBCCCDD@@@DDDE#
@85V
TTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTC
+
CCBFFFFFHHGHFHIIIIJJJJJJJJJJJJJJGIIIIJJJJJJJJIIIJJJJJJJJJJIJIIJIIJIIIIJJIGIIJFHJJJIJGHEHFFFDFACCEEC
@85W
GTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGG
+
???DDD>:32:???E>D?DAD<:<:C:CEB3AE<E>??DEID>DD@D9DDD@D>:=<84BC;;8)=@@AAAD3=CACC:A>@;A(;96;?6>A>>>ADA
@85X
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
@C@DFFFFHHHGHJJJIFHGIIJJJJJJIIJIJIJIIJJJJJJJIJJJGIIIJJJIGIHHHHHFFFABD@DDDDDDDDBBDDDDDDDDCDDDDDDDDDBD#
@85Y
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATN
+
??@DADDEBDFHFGIIFDEGEBGIIIGHGIGDGDCDCFHGIIIFIIIIIIGHGGIIEFFHIEGGGGGHFD7=>3?B3=@CA@:@CDDD>@C58?0>ACDA#
@85Z
GTGCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGGAGAGGCGGCGGATCATGTTGTCCAGGGGGGACCGGAGGGGCCGCTGCTCGGGGTC
+
=@1AADDDA?DFFIJJIIIHGIGFHIBFHIIJIJJBH@HHGGE@GEEFF?B==@B-:BBC@CDCCCDCCDDDDDDDBDB9@D@@>>BD@B@@@8>@D<@
@860
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
@CCFFFFFHHHHHIIJJIGGIIIJJJJJEFHDEHEHFGIJJJIIGGGIGHIIIJIIHHEDDEECEEEEDDDDDCDDDCDDDEEEDDCACCCDDDDDBDDD#
@861
GTCTGTATGGCCCAGGTAGGGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGAAGAAGGN
+
??@DDD<;=?DBDGGGHBG+AGFCAFC)1?FFHECGE9F<D<FAGBDBGGG=FDHGCHI4=@)>=@=@)==C<EFD>BC7?>C:AC@BB@BBB9<0<93?#
@862
CCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCN
+
@@@FDDDFHHHHHHGI<EGGHIGIIIHJIJJIHGHIJJJFGDFGIJGCGGIGIFFDDDDDDDDDDDDDCDDD?B5@>BCDCCDDDDDDDDD:@B:>CCDC#
@863
CTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTN
+
@CCFFFFFHGHGHIGIJIJJIJIJJJJJJIIGHGIIJIBFGGIJIJJIIIIJJIGIJJJIJIGHIIGIIJJIIIHFHEHFFFFEEDDECCCADDDDDDC@#
@864
GCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGGGATTTACCGCATGTAATTATGGTATTN
+
@@@=D32=,:4C:AA@:ACFFGCCFFDGF@@GHE@B9C?<?CC9C9DF3@F?D68=;83==C=8=;DE<E)7=).7;@;@@(9<@8=5@>>B;(;:,,,(#
@865
TCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGN
+
@@@DDDDA?<FFBFHEIEHIGE?B@HEHGIHGEGEIGFHDD?DFFHGIBFGECGGF=CCDHGIII=?EH<@DEEEED>AC@CBB;@BCC:A:@:>@@::@#
@866
AGGACACCAAAAGACCATACATCACTTTGCGTGGTGTAGATATGATCAAAAAGGGATTCAATTGCCATCCATTTAACTGGAATCCGACCCTGGCTCCTCTN
+
@@1DDDFFGHFHDHHIJJJIIJJJJJJJIJJJIIDGFFHIIIJJEIJGIIJJJJIIJJJIIJIHHHHHHHFFFFFFFEEEEEDDDDDDDDDDBDDDDDDD#
@867
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
CCCFFFFFHHHGHJJFHIJIJJJ?FHIIJJJJIJDGHGJHJJJJJJJJJJJJJJJJBBHHGHHHFFFCDEEEEEDDDDDDDDDDEDEEEDDDDDDDDDE
@868
CACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAATAGTACTACTACTGATGCAATGAAATAAACTATTTCCCCGGTCGGA
+
CCCFFFFFHHGHDHJJIJIJDGHDHIIJIEHDHDDAGFDHJEHGIFGHIHIIJIICHIGJIIIHHIGGGGIIJIECCHFHGDC>CFFCCECBBBBBBD
@869
GTGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCN
+
@@@FFFDFHHHHHJGIIIGIHHIBHGIGHIIFHGIHGIGCHHGHHIJFEGHJIIIIJFJIJIJHEEDFFFFDEDD>CDDDDBDDDDDDDDDCDCDEEDDC#
@86A
CGTGTTTTCATTCGATTCCTGTCTTCTGAGGATGAAGATGACTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCN
+
@B?DDDFFHHHHHJJJJJJJJIIJJIJJJJJJJJJJJIJJJJJJJJJJIIJJIJJJJIDHIIJIEHIIIJIJJIHHHHEEHFFFFFDEEEDDDEDCDEDD#
@86B
GGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCN
+
CC@FFFFFHHHHHJJIJJJJJJJIJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJIJJJIJJIJJJJJHHHHHFFFFFFFEEEEEDDDDDDDDDDEEDD#
@86C
ATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGN
+
CC@FFFFFHHHHGJJJJJJJJJJJJJJJJJJJJJJJJJIJIIIIJJJJJJJJJJJHHIJJGHJIJJJIJIJJHHHHHHFFFDDDBDDECEDDDDDDCDDD#
@86D
CACATTGCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJGJIGJIIIJJJJIJJIJJGIJGGHIJJJJJJJJJIIJJJJHFBEF>CCEEECCCCDDCDDDDDDCDDDDDACD#
@86E
GCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGT
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJIJJHHIJJJJJJJIJJJBGIIJJIJJIJIJJIJJJJIIJIIIGFGFFFEFDDEEDDDDDDDDD?CDDCDDD8
@86F
TCTCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTTN
+
?@8:B;22=?<?CEFEFFCFEHC:?<CHH<CE9?<E?D>F9?D*:0:DGE9B08BFF@FE>CF=@CFFFGI>;@>=4=3??A;??BD;>B:;66;;;;@B#
@86G
CCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTN
+
CCCFFFFFHHHFHJJJIJJJHHIJJIJJJIJJJJJJJJIJJJJJIJJJIJJJJIIIJJIJHHHHFFFDEEEEEEEEDDDDDDDDDDDDDDDCDDDDDDDD#
@86H
GTTTTTGGAGAAGCACAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGN
+
@@@FFFFFGGGHDGHGGIIIIJJJIIIIIIIICEGGGIIJFDHGGIIIHGHEGBHIEG@GGHFFEHFE=>ACCDAC@CCDCDDD=@BCDEDDCDDDCCDD#
@86I
CTCAAGTTTTTCCATGAGTTCTGTTGTATCCTTTTCAACAACCTCACCCATTTCCAATGTTTCTGCTACAAAAGTTTTGTCTTCCTCAAAGACAGAACTTN
+
?@;DDDDDBF=3:CE@333A9A@HF>3<C@9AH>A9?4?F3:?:?BFEFDDFGB<??B*?B>8B)88BCF)/=C@EFDEE:?CF);7?>?;@;>;@B;>@#
@86J
CCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTN
+
CCCFFFFFHHHHHJJIJJJJJJJJJJJJJIJJIJJIJJJJJJJJJJJJJIJJJJJHHHHFFFFFECEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@86K
GGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTG
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJIIJJJJHHHHHFFFFFDEDEEEDDDDBDDACDDEDDDDDD
@86L
GGTAGGTGAGCTGGGAAGGCCCGGTCAGGTTTCGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGN
+
?@=ADD=DDAHHFGEHIGHGIEGEHIIIIHIIIIIDGIGHIIIHHIGHGHIIIIEEHCEFHCHFFDE@B@CDD??BDDDDDD9@DBCC<CCDCD?BDDDD#
@86M
CTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTN
+
CC@FFFFFHHHHHJJJIJJIJJIGGIHIIJIIIJJJJJJJJJJ?GHIFHIJBFGIFFHIIIHCHHHFDFFFFEDDEDDDDDDDDBBDDDDDDDDDCDDDD#
@86N
CGTTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
B@1=DDFDHHHHHJJJJJHHJIJJJJJJJJJJDGHJJJJJJJJJJJJJJJJJJJIJJJJJJHIGHHHHHFFFFFFEEE@CCDCCDD8ABDCDDDDDD<AC#
@86O
GTCCAACTGAGCGCCACTGAAACTTGGAGGCGCCTCTGCATCTTCCTCCTCTTCCAAGGCCATGAGTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTN
+
?;;BDDDD8CFBAGA<FEEGGIGIIEBHCEG:@GEHIGCGBGHIIIIFGIHAAGIEH;==BB@DC>@CCBBBBCC:>ACB??@:<BBC?8C8+4@C4>CC#
@86P
GGACTTTGATCATTAGAATGAGATTCCTCTTTTTTTTCTCTCTGTCCTTGTGGTTTTTCTTTCTTTTTTTCTGTACCACTTTTAGCAGCAGATGAAAG
+
@@@DFEFFHFHHHJIJIIBGIIEHICIIJEIIIJJII?DGBGIHIGGFGGIHHIJJJJIIGGCEHHHHDD;ACADCCDC>CCDCC:@AABD<CC>ACD
@86Q
GTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTN
+
CCCFFFFFFDDFFIGGDH@CGGDFHBC<FCFHGI?C9?9?FBFFGGGGB9DH?DDBBGGH@@FGHBF7=7@C>EHFEHC;CF>@@A@@C>>CD?5;:3::#
@86R
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
@@@DDFFFHHFHHIJIIJJIIIJJJJJJJJJJJJJJIJJJGIJJIJJJJIJJJJJJJJJJIIIIJJIJJFHHHHFFDDDBDCDDDDD@ACDDEDDDC
@86S
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAAGCTGAGTGCCATATTCAGACTGAGCTGCATAGGAAGCCTGGGTGGTGGCG
+
+:?1+A4A::2A<A3;B;C13:3+AF=CBE>?DCD9?BDFDFBB@B*?*/?BB92C;78C>))).7@4@EE;)777@3?)((6((5=(((,,3/8?(()
@86T
CTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTAGTTCGGATCTGATATGTTTGCAT
+
???DDBBDFHDFAAABFAAB??E+AFHHDE8??FFFH9DFGHIGGEG@DECHGGH?CHH;@FFFHGG@D=@C.=AEEEEEEC=C@@CCDCCC>CACCCD
@86U
CCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTN
+
@@@DD>BDBFAFDDE1<?@@FFF?EFFDF?FEFF@??@?B<DE=@@AFA9@3@@:AE@?CB;BB@AC@AD@>@BBB3-555:?@BB?<ABABB99:3(4>#
@86V
TAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATN
+
@<;BBB?ADABB?DBGEBHIGHIIGHCEGGIHIICHGIGEEEGGDGDC@@DE7@@EEE3;;@@CC36:ACCB?,;@C@CCAA?CCCCC(>CA<952>CCD#
@86W
TAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGN
+
CC@FFFFFFHHHHJJJJJJJJIJJJFGIIIIJJJJJJJJJIIJJJJFHIIJIIJJIIFFDDDEDDDDDDDEDDDDC?BCCDBDDDDDDDCDDDDDDCDED#
@86X
CTCCAGCCCCAGGTTACCCCTGTCGTGTGGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCN
+
B@@FFFFFGHHHHJIHJIJGGGHGIJJIGGIGIHIJJJIJGJIIIJJGIIIIJJIIJJJJGGCEHFEEDDEEDCEFEEDDDDDDBBDB@>BBDDDDDDDD#
@86Y
GACTAATCCACCCCGGGGGACAGGCCCAGGGCTCTGAGGAATTCCATAACTTGATGGAGTCCTGTCCCTTTCACGGAAGAAAATGGACTTAAGCTATAGCN
+
@@;DDFFFHHHHHJJJIIIIJIGHHGJJJJHGHHFFFFFEEEEEDDEDDDDEDDDDDDDCCCDDCDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDEDD#
@86Z
GCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCN
+
C@@FFDBDHFHHHIDHAFDHCEHCACGIEFEHIIGHII?BDEGIIIGIIG@FGBFHGHGEEEEHGBHB<BFC6@AECC>CA@C;@?B<@C@B?8<>@CAB#
@870
TTGTCTTATTAATTCTTGTTTCATTTGCACTATCTGCTGCCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCN
+
@CCDFFFFHHHHHJJJJJHIIJIJJJJIJJJJJJIJJJJJJJJJIJJJIJJJJJJJJJJIJJJJJJIIJIJJHGGHHHFFFFFFFECCCEDDDDDDDDDD#
@871
TGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGCACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCT
+
@<<=DDF??FF?FGIIGG>FCGHIEH9CBGGC=)??D;BDGEAEHEG<BB@D7.=C@DGHEDG;;@?=AH;=BDD@C;;9>?5;?=C>>CB@B@B4:>C
@872
CTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCCATTCTGTCTAACACAGC
+
CC@FFFFFHHHHHJJJJJJJIJJJJHIJJJJJJJJJJJJJJIIJJJJJJJIIJJJJJJJJJJJJJIJJJJJIDHIJJJHHHHHHFFFFFFFEEEDDDDD
@873
CCATAGGTAACCCTCATTTCTTCCAGCTCTCTGTTTAGCTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACN
+
BC;DDFFAFHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIIJJJJJJHHHHHHFFFFFFFEDECEDDDD#
@874
GCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATN
+
CC@FFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJIJJJIIJJIJJJHIJJIIJJJJHHHHHFFFFFEEEEEEDDDD#
@875
CTTATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCTGTTCTTGTAATTCTCCTAGTAATTTATCAGCAGTTGTTAATTTATCCTTTAGCTCA
+
@B+ADDFDHHHHHJJJJHIJJIJJJJHIIHIJJJJJJJJJJJJJJJJIJHIIIJJJIJJJJIIIJJJGIIJJIJIHIIIHHHHHHFFFFFFFECEEDE
@876
CTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTN
+
@@?DDDDFGFF>DGF<FFFGIGHIIIBGH@HGIIEGGIBEHIIIDDGFBFCGI@CEDHEE@EHECHECHA@=/9;?=A@@:@5>C>>A>ACCCDC:>CB@#
@877
CCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGT
+
@@@ADFDFH>FHGIAF@AAHHC@GH1?@@FG@A:BFHIGC=CFGCHGGI=FGHI/=ADFBBE@CE>@;;>C>9ACCC@@@A@::@@>@C<ACCB3>82
@878
AGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGN
+
CCCFFFFFHHHHHJJJJJJJJHIJIJJJJJJJJJJHHJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHEFFFFDEEEEED?CDDCDDD<CBDCDDDDDD#
@879
GTTTATCATAGTTCATAGCTGGCCTGTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGATTAAATTCCATGCCTCGACCAGTCC
+
@@@BDDD?B??2A:<?<:?33A:<CC3CHGC??*:1111:?D;FB6FG6F6F;;;6C>EF3A7@;;;766;;;(---;;5;5:5(,:5(>2?5002+::
@87A
CAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGN
+
CCCFFFFFHHGHHJJJJJJJIIJJIJJJJJIHJIIHHIIGHHFFFEEE>C?CCDDDDCDDDDDDDDDCCDDDB?BDDDDDDCDDDDDDDDECDDDCCCDD#
@87B
CGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTN
+
@@@DAADDHDAHGIIE?EFFIEIGIIGICH@FDGDHG<<DFFECCCEGGBFFGIIHGHGFDAFCHGCH>GEFAHEEEFBC;>5;@CC;ABABCCCCCCC9#
@87C
CTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCN
+
CCCFFDFFHHHHHJJJJJJJJIJJJJJJJJJJIJJJJJJJJBGIEHJHIJJJJHIJJJJHHJ@EH=EHHFFFFFFEEDDDACDDDDDDDDDDDDDDDDDD#
@87D
GTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCACGCGGCCC
+
CCCFFFFFGGHGGIJJFHIJJJJJGIIJJJJJJIIJJJJJJJJJJEHHHFFFFFFEEEEEEDDDDDBDBDBADDDDDD>CDDDDECDDDDDDBBB@BDD
@87E
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
CCCFFFFFHHHHHJJJJJJJJJJHIHIJJJJJJJJJJJJJGIIJHIJJCGHJJJJJJJJ@EHHHHFFFFFFDEDDDDDDDDBBBCDDDDDDDCCDDDDDD#
@87F
CCTGTAATTGCTGAAATTGAATCTGTAATTTTTGACTCTGTTCTGTCAACTCTAAAAATTCTCTCATTGTCTCATCCTTTTCTCTTCTTGCTTGTTGTA
+
@@<DDDAEFGGHHGIDHIH@HIGGEFHHIIIIIGGICEDHHIEDGFGHIIDHHIIIIHIIIIIIIGGCGIIGIIIIIIIIIIIIFHFHHHCFFFFBEA>
@87G
CCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATGTGCCTCCTTCAGGA
+
@@@FD?DDHHDFADGGEGGCFBHHIIHGIIIDHIIIGGGHIIIIBFEHCHIIHGIICHIII=@CCAGGIEEGGC@EDFFFD>>AC;;;;@CBCCCCDDC
@87H
GCGAAAGTCCTCTTTGGTCAGCAGCAGGAGAGCTTTGCCATTCATTTCAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGN
+
@@@BFFFDBFHHHEHHGHHIIGIEIGGGIGDHIIIGBHHJDIJGHIJIIHEHGFBCDGEHGIJJJJGGGGHECHHGFDEFFEDEEDEDDDDCCDBBDDDD#
@87I
GGCGGTGTAAGCACTGTAGCCCTGGTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTCTCCTTCCTCCTCGTTCTCTCAACGTN
+
@@@DD=DDBDFF?GA:CF,<+2A<8<C4CGGFIDFFFFFBB<?DCFF.=CFE=@FF@F8ED:?A/<B=?BDDAABBBB>>A?AA?<@@?@@8>3>@B9@?#
@87J
CAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTGATCCTCCATCACCACGAAATCCTTGGTCTCTAATCAAGTCATCAATATTGACAGGTTCN
+
@@@FDEFFHHHHHJJJJIJBB7:BDDDDDDDDDDDDCCC<?BCDDDDDDDDDDDDDDDDDDDDDDDDDCCDDDEDDDDDDCDEEDDDDEDEDDDDDDCDD#
@87K
GTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCCCTGCCTCTTGACTGGCTTCAGGCAAGGAGGAGGCATCCTCAGTCCCCATGATAAGGAGATTGCN
+
@@@FFFFDDDHFHJGIJIEIEFGHHHGIIIGGIGFHIJGGJIJJIJJGGGIJIJJJJIJIJJJJGIHGHFFFEEEDEDDACDDDDDDDDDDDDDDDDDDD#
@87L
AGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGAGATGGCTCCGAAGTCAAAAAAGAAGGGGCACCCCGGGAGGG
+
BBCFDFFFHHHHHJJJJJIIIJHJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJHHHFFFFFFEEEDDDDDDDEDDDDDDDDDDDDDDDDDDDDDBDDD
@87M
CATCTATCTGCTGTTTATAGTGAATGCCTGAATTATCTTTAAGTTTTTCAATATTTATTCGATGTTCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCN
+
+:;B?D;2A?A?<<C@:<3<EE43:C<3<+A++2++*1?9???D99DC:??DC>?B@BD?D9D*/0/*/8BC)88BAE88)./=CC3)=??=;CA7?7).#
@87N
CTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTN
+
@BBFFFFFHHGHHIJJJJGIIGIIJEHGHGGIIJJJIJJGIJJJIJIJGIJJIJJJJGFFHCDHHIJIIIFHHHHHFECEEFEDDECDDDDCCDDDCC?A#
@87O
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
@@?DDDDD?FHF?GGGG:FDECHIIIG@E?EFFC<9FHDGHHGG<=CFHGDEGHHHFCAH7?;@@DCCC@;?@CC@CCCCCCCC@8>>@CCC:@C@C@34#
@87P
GCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJGIJJJJJJJJIJJJJJJJIJIJIJJJJ;BFDBEEEEDDCDDDDDDDDDDDDDDDDDDDDDDDD#
@87Q
GGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGT
+
??:ADD?ACDACF<CGHCAFEHIHG=GEBBEHGE?HGHGGGFBHIGBDBFCGC@AHGGA@C=CEFCEHEDDEEDECCCCCCEEC@CCC@@@BCBBCC?B
@87R
GTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTN
+
@@@FFFFFGHDHFIGG?FHHGIJJHIJJIIGHHIHEFBDBADECCEDDCCCCDDDEDDDDD:ACDDDDDDDDDDDDDCDDDDDDDDDDDDDBDDCCDCB@#
@87S
CTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTN
+
@@@AAB?;=AAFDG<?2<FBHEIAH@DHEIGGFHEEGIIII:CEGBG;9DABGAFD@EHIGB/8FHIGHA;ABB3=8@CCCACCC::@C@99?8>@3<@>#
@87T
CTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTN
+
???=D;2ACA:3CE><E::AFB<:<C,2CC9C9:??EF<D3D;D90:?:9*9B3B<9??8?8B)./B).@DEC=7=7C7)7)==7).)...((..(..--#
@87U
TCAATTTCTAAATCTTCCTTCAGTTTGGAAAGCTCTTCTTCGTGACTAAATAGAAGCTGTGTTCTCAGCCTCTCTAATTCAGCTTCTTGTGATTCAGCC
+
BCCDFFFFHHHHHJJJJJIIJJIIIIIJGIJJJJJJJIIJIJHIIJHIJJJJJJJIJIJEFGHIJJJJJIIJIIJJJJJHHHHHHFFFFEFEEEEECED
@87V
TCTAACACAGCATTCTTTTCTTTTTCTAACATTTCAAGTTTTATCTTGTAATTTGTAACTTCTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTC
+
CCCFFFFFHHHDGIGIJJJJJJJIJJJJIJJJJJJJIIJJJJHGIJJJIJJJJJJFGIJJJHJJDGIJJIIIIJIIIIJHIIIIIGIHHHGGHHFFEF
@87W
CTCCATCCGGTGGCCGGTCTTCAGAAGATTGAAGAGCCGCTCAGGAGGAATCCCAGGATAGGGGTTTCCCCCTAGGGTCACGATCTCCCACAGCAGGAC
+
CCCFFFFFGHGFFHGIJGIIIGIGIJG9BGEGGIIIJJIIIJJIIIGIHHHHGGFFFFEECECD;@BCCDDDDDDDDCDDCDDBDBDDDDDDDDDDDDB
@87X
GATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCN
+
@CCFFFFFHHHHHJJJJJIJJHGGIIJJIJIIGIIECEGHGIII>GGHGIIEHHGHFFFFFFDECCEBDDDDDDDDDDCDDDDDDDCCDDDDCDDDCDDD#
@87Y
TGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGN
+
CCCFFFFFHHGHHHHIJJJJJGIDHIIGJI@DHIBFHJJJJCHIIJJJJJJJHHHHHFFFFFEDEEEEDDD?CDDDDDDDCDDDDDDDDCCCDDEDCDDD#
@87Z
CTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATGN
+
@CCFFDFDHHHGDHGHIIIGHHEDHGFGHGGIGGGGEIIIGIGIIIEHIIAFGGEHIGIEIEHCDGGAHIGHHGHDDDFCCCCEECCC@@CDDDDDCDDC#
@880
CGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGN
+
@@@DDDDDF?FDFHGGFGHGII@E?:GGHGGGHIABDGGGIFHGIEHIHGDGDBGHCGHIIIIIDECHHFBBDECBACB>C@CCDCCCCCCCCC>CCCCA#
@881
TTCTAACAATTCTGTTTTAAGTTGTAATTCTTGAACTTCTTGTTCAAGTGTACCCTTTTCTTTTTCTTCTTGTCTGAGTATTTCAATTTCTTTTTGAAGTN
+
CCCFFFFFHHHHHJIJIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJIJJIJJJJJJJJJHIHJJJJIIHHFHHHHFFFEEE#
@882
ATTTCATATACTTTAATTTTCTCTTGCAAGAAACTAATTTGCATTGTGAAGTCTTCTTTCTTTTTCTGATAATCTTCTAATAAGTGGTCTTGTTCTTCA
+
@CCFFDEDHHHGHJJGJJGJFHIGIGGGHIIIIJJIGGHHIJJJJECGDDFHEHHBFHIHJJJICHDBBFHGIEHHGIEEHEH@DAC=?CHEHFFCCCF
@883
TAGTCGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGGTN
+
@@@AD8A<@CF?BBF<AEEEAH:?FEEB6?DGCEFEHICHGCIIGDHE;=;;=CEECEBED@ACCCC>CCA;;;??:@>:>>@CC>94(:>>4499<9.9#
@884
GAAATATATTATTACTCTTGAGGTCTCTGTGGATGATTGACTTGGCGTGTAAGTAATCCATGCCTTGTGCAGTCTGTCGTGCAATATCTATAAGTTTGATN
+
CCCFFFFFHHGHHJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIJJJHIIJJJHFGIIJJJJJJJJIIJJJJJJJJJHHHHFFFFFEEFEEEEDFFEDDD#
@885
CTTCTGCTTAGTTATCAAATTGTCCTTTTCAAACTGCATGGTTTCTATCTTTTGACTCATTTCATTCTGTAAACCATCTATCTGCTGTTTATAGTGAATGN
+
???BA?+=ADDDDEEIIIC:F<F?:A<CBBFIFB@EEEFA?1?8::D?9:???<DEAD<D@D?DD@BC<CEIB=76)8@DE@=7;47.7A37......)(#
@886
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@@@DDDDDDHGDFHJGIIIIIIGAGII<GEGIGGGFHHIJGHGGGIIDCH@FCHG>FCHHGGD>ADHEHHFHFDFFFFFDDD@=?B8ACCDCD3>ABDDB#
@887
CTTCCTTTCTCGCTGAGGTCCTGGAGATTTCTGTAAGGCTTTCACGTTAGTTAGTGAGCCAGGTAATGAGGCAGGGGGGGTAGCAGACAAACCTGTGGTTN
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJIIIHIJJJJJJJJJJJJJIJIJJJJJIJJBFHGJIJJHHHFFDDDD9BDDDDCDDDDDDDDCDDC@#
@888
GCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTN
+
CCCFFFFFHHGHHGHJJGHIJJJJJJJIJJJJJHHJJJJJJJJJJJJJJJJIJJHDDDDDDDDDDDDDEDDDDDDBD@DCDDDDDDDDDDCD:@BACCCC#
@889
GTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGA
+
BBBFFFFFHHHHHJJIJJJFGIIJJJJJJJEHIJJJJJJJJJJJIIJJFHJJJIJJJJHHHHHHFFFFFFFEEEEEDDCDDEEEDDDDDDDDDDDDDDD
@88A
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGCGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
@;@D?D;?=+2C?FC?FA<AI<?<<:<?A9C9E<GB??E?::)000?F99??D/888@8)../).87==7C@A=C77=).7.).6.(.((.-55@>>;5
@88B
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFHHHHHJJJJIIJJJJJJJJIIJJJJIJJJJJJIJIJJJJJJJJJJJJJJJHHHGHFFF>@D?CDDDDDDDDDDDDDDDDDDDDDDDDBDDDD#
@88C
CTCAAAAGAAAAACAAACCAACAAAAAAAATCAACCCCACAAAAAAACTCTAAACACATTCATTCTTATTTGGTTTTCTCTCTTAGCAACTCACTCTGCTN
+
@BCFFFFFHHHHHIJJJIJJJFIJJJJIJJJJJJJJJIIIJIIJHFDDEEDDDDCDD?ACADDEDDECCDEDCBDDDDDDDCDDDDDDDDDDDDCCDDDD#
@88D
CTCGGGGCCGCTCCAAAACACGACCTTGGGTAATGCACTCAATGACCTCCGTGTTTGAGAGTTGGAACCATGGCTGCTTTCCATAGGTGAAGATCTCCC
+
@<?DD?<DAAFAFEHCBGB@GF6?DGHIGGIIIIGCHCGDHGIEHC??DD8;=AAC9(;=C;>CCCCCB?A:?8<?@C@CCCCACCA>CCCCCCCAACC
@88E
CATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTN
+
@CCFFDBDFHFHDGIIAECEEDEHGHGIICHHD1CFG??FHB?BG=BF?DEE;CE@77==?CEEFDD=CCEEBB9>;A>CCBCCBCCCCDC?BB@@?CAC#
@88F
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
CCCFFFFDHHHHHJJIJJJIIIIJJJJJJJJJGIJJJJJJJJJJJJJJJJHIJJHIIHIJJJJIIJJJJHHHHFDFFDEEEDEEDDDDDDDDD:@CDDC
@88G
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGCGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
?@@DD>ADBCFDDFGD;ACDGI8FHGFGHIIDGFGECCB@<FHGIIIIIIHIHG7@CHHFDHFEBD'305@BCC@C@@@B?C:CACCCCACCCBBBB@??#
@88H
CTCGAGGGAGGGGGGCATTATTACAGTCCACCAGCGGTGTCTCCTCCTCTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCA
+
?@@D;DDA@?CFFHB66CCCCEDCC>DACCABBBBBB00688>C>838<>CCACCBB80;<B58<ACCCECCA>?80?CCCCCCA><>88:>-95559
@88I
CTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGN
+
@C@@DDDDDBADFB<FHE@ECAEAACF@EGEEE41?GH@*9BAAHHIECG@EEE>AF)=8=CEFBG'530>@DC:@>4++(8?7???@::+88@?9CCA@#
@88J
CAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTCTCTCCTCATAATTAAAT
+
CCCFFFFFFHHHHJJJJJJJHIJJJJJJJJJIJJJJJJJJJJJIJJJJJJIJJJHJJIJHJJJJJFHGGHGIIIHHFFDFFFFEEEEEDCDDDFEDDD
@88K
CTCCCTTGTAGACTGTTCCAAATGATCCAGATCCAATTCTTTGTCCCACTGTAATCTGCCCATCAGGAATCTCCCAATCATCACTCGAGTCCCGTCTACCN
+
<@@D;BD8==A:AE<2<ABD>E?DE9EDHDEH@GFD>@DFEFFDAFBFFFAFFA?BD?<DFIIIII=FAE>CFGDEBAEFA?>EA@D;36>AABBBB=>B#
@88L
GAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCN
+
CCCFFFFFHGHHHJGIIIIGIEHHEHIDHIIIJJIGDCHHDFIIIHGIHGHGIGIHDIDHI@G@EGGHIIGHEEEBEBA@BB=C?@CC>5>AAABBB?BD#
@88M
CCATCGCCGCACACTCCATAGAACTTGACAATGTGCTCATGCTGCAGGTTGGTGAGCAGCTCGGCCTCCCTCTGGAAATCCTTCCGGGCAGCCAGGGTGGN
+
CCCFFFFDDHHHHHIJIIIIJEHDHIIIJIJJBGEIIGJJCGHIIIHHEGEGHCHGGHGFHHDBCDDEDDDDCCCDDDDDDCDDDDDDDDDDDBDDD9?B#
@88N
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFHHHHHJJJJHIJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFABDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@88O
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
BBCFFFFFHHHHHJJJJJFFIIDHIIJJJHIJJJJJJJJJIJJJJJJJJJIJJHHHHHHFFFFFEEEEEEDDDDDDDDDDDDEDDDDDDCDDDDDDDDD
@88P
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJIJJJIJIJJIIJIJJJJJJJJFHHJGHIJ@EHGHHHHFFFBCEEEEDDDDDDDDDDDDDDDD@BDDDD#
@88Q
CCCTTCTAGGCAAAGTGCTTCCAAGGCCCTGGTGAGAAGATGTTGCTTTGGGAGTCCCAGTTGTGTAAGACTCCTGACTCTCTTGTAAAGGAGCAAGGTTN
+
@@@DFDFFHGHHGJJIIGHHGGHJBEGIIIIJBGGHGGIEHIIEGGIGIIJGDGBFEGGJIIGHIGJJJJHHHGHDC7@D?AAECCEEACDDDDDDDDCD#
@88R
TGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGGATGCTCCN
+
@@@DBFFFHH>DFGIIGGHGIICFHHGIIIIE?EFHD?DHFCBAFHIGIGIIIGIDIGAEFHFEDFFEDEEEDDB?CBD@>:A?:??A::?BDBBDBCDC#
@88S
CTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTN
+
@@@FDDFFHHHFHIGIIEHIIIEFGIBHHDHEGGEFGGIIJIGHJJGHH?FGIIGIIGHHIIGIIHHHFBD<<ACC>@CD>ACDDCD=<???4AABDDBD#
@88T
GCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCN
+
@?@AADBDFHDHB<BFHH@F>FCHGH<EA<FEGBDDDD@DHI00.@7=;FC9@FA;=EA:?;B=>;A>;@CC>@;>A>CCC><<>>@>ACCCCDCCC>:>#
@88U
GTTTTTCTGAATGCCCCAACGTCGGGCCACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGAAGGGN
+
CCCFFFFFHA>ACGHIJJJJJIJIJIIJJJJJJJJJJJJJJJIJIJJJIJIJIIJJJJHHHHHHFFFDDDDCCDDDDDDDDDDDDEDDDDDDDDDEDDDD#
@88V
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJJJJJJIHIJHJJGHIGIJIJIJJJJJJJIJJIJJGJJEIIIJIIJIIHHHHGGFFFDEEDACCDDDDDEDEDDDDDDDDDDDDD
@88W
CTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGGGGTGGTG
+
@@?DDDDA<B3C2CD97C;FG@GFFFE9:3ED<D9?3:BF??<?D<<*/(62B@@F)>F;.777=)77=CFA:B3).6@36>35/=5319<'55>.&&2
@88X
CTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAAAGCTTCATTN
+
@<<DDDED?ADDDEA@FHGDHEHAFFGHIGGHEBEGBDCDFII@D?GBD>@DBB>?DF@;FB=BAF;8@FC7@GEEHHCAHHCDDCEE>;C@EE@AC>A@#
@88Y
CCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGN
+
@@@;DDFDBFAFHJJIJJJEEBGGIHGIJIGGDHIJIEGHGG>BGDFHHGGBGHGIIIGGHIHIGFHECC@DEDBBA=AD5;@C>CCCCCCCCDDCCCCC#
@88Z
CTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCA
+
C@@FFFDDHHGFHIGIIHIBAGHIIICIFHGGIHGIIGGHIIIIIGIGG@FGGIEGGHIGGEHIHFEFEFF@BDCCA;AEECDDDDDDEEDEDDDDDCC
@890
GTCTGAGTGTCCTAATTAAAATCTATTAAACTAACCTCTTCAGGCTCAATCAGTTTAAATTCCATGCCTCGACCAGTCCAGGCAATAAAATGAGAATTTGN
+
1?=?D;A2:C??DBE@C?:EAED>AFEIBC@EFDFD@;EEFII>DBDEAD?:B?DDEIIIIBDD>D;B8BDD@A4=7=AD?7.;@;>AAADA>A>>AAA>#
@891
CACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGN
+
@@@FADDFHDFDHGIIGDHG>EHIIFDFGGIBHGADFDFGG8DDGGECCGG9C;D@EGEIHGEDDDFD@CCE=?@BD;C>C@ACBDBD?:@>>>>CCDCC#
@892
CTACGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGTGGGCTGTTGGCCCTCAAAGGTCCTGGCAAGCTGCAATAGTTTCTCTTTTCT
+
@@@DDDAD<4<<<E@G<EAEDCHBHEEHHICECGCH>B:DCG@GGGHDHIIIBFHEHFEDHIDECHHHDE@DD@;>;?C>;?;>AA;@CCCCCCCCC:
@893
GTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTN
+
CCCFFFFFHGHHHIJJJJJJJIIIJJGHJFGGHHIJJJEHHFFFFFEEEDEEEDDDDCCCBDD@DDDABDD@BD?BCDDDDDDCCDDDDDDDBD>CDCDD#
@894
CGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCN
+
@@@DADEFDHBFHGAEFHGIIIGEAHGIIGEEGHGIGDHIIIIIIIGHGHIEEEHGIIGIIIGEDCA@CCCCCBCBBBCCCCCCCCCCCCBCBBCCCCCC#
@895
AGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAG
+
CC@FFFFFHHHHHJHIIJJHIIJGIJJJIIIJJJJIIIIIJIJJJIIIIJJJJIJJIJJIHGFFFFFDEDDDDDDDDDDDDDCDDCDDDDD
@896
TATTAATTTGGGTGTTGAAGGTATTTTCGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTN
+
CCCFFDFFHHHHFHJJJIJJJFHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJHHHHHHFFFFFFFEEEEDEEDDACDDDDCDDDDDD#
@897
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFGHHHFHJJJIIJIJJFIIJFHHIJIJJJIJJJJIIJIIGIJJIGJIIIJJJIGEHHFHHFFFEEE@ACCDDDDDDCDDDDCDDDDDDDDC
@898
AAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTAAAAAGACGAAGAAAAATAATAGCAGCA
+
@@@ADFFDHHDHGEHIIIIIIIGGAFCCFHIHGFDCHGGD@FGGGIIIIIIIEAEEEHF=BFDACECDDDDDDCCC??CBDBBDDDDD@CCDEDCCDB?
@899
GCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTN
+
CCCFFFFFHHHHHJJJJIIJJJJJJJJJJJJJJJJJJJJJJIIIIHJJJJJJJJJJFHIIJJJJJJJGIGHHFHHGFFFFFFEEEEEEDDDDDDDDBDDD#
@89A
GGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGN
+
@@@DDDDD+ADD7?EE>;A?FGIE>FGBDE@3::?C??BBF9?G<F@>A?<9=BFFC@GFA@CGAH@3.=<=BCDAC@CB981,(55>:>B(+>A(:>4<#
@89B
CCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
BCCFDFFFHHHHHJJEHIIJJJJJJJJJJJJIJJJJJJJJJJIJJJJJIJJJJIJJJIIJJHHH<BD@DDDDDDBBDDDDDDDDDDDDDDDDDDDDBDCD#
@89C
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFFFFHHHHHJJJIIJJJJJJJJJJJJGGIJJJJJJJJJJJJJJJJJIJIIJJJJJHHHIJIJJHHHHHFFFF?CEDCEDD?CBDDDDDDDD<AC
@89D
CCTCTTCCTCTGCTTCCTTTTTCTTTTTCTCCTTTCCTTTGGCCCTGTCTGCTGACCTGTGTGTTTTACTAACAGAAGTTTCTCTCGGAACTATGGCATTN
+
@@@FDDB?B?HHHIGBDGGGEHBDFHEFGAHCEFCEGAHG@3DFD;DDGDHIIE4?B?;?B=B8=C>4@CA)=EHCHC=ACHE>;;BCCBB@;;>;9?CC#
@89E
CTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTTTTCCCACACAGAGTCTTN
+
@@7D7?DD<?FF<@E::C<DHCHIFF<FD9E9CH9<21?@E9CBD4:??B<?94909?B<:D8/.=B<=4=;C=F4@=C@D;@=3??>:;(;?@>;..;;#
@89F
GAATGAACATGGTAATTGGCCGACCGCGCATAAACATTTTAATATATTCTCCTTCTTGGTTGATGATGACATCTTTATGCTTGTCTGCAGTTTTGGTAACN
+
CCCFFFFFHHHHAFGHIGGIJGIJJIJJJIJJJJJIJIJJGIGIIIIJIJJJJJHHHHHEFFFFEEDECEEDDDDDDDDDEEDDCDDDDDCCDDDDACDC#
@89G
CATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCN
+
CCCFFFFFHHHHHJIJJJJJIJJJJJJJIHIJJJJJCFHGGIIAHHJJJIJHIIJIJ@FHHIJJFJGHDBDDCDDCCDDDCDCDDDCDDDDDDBDDDCCD#
@89H
AATAAAATGAGAATTTGAAGGGTCATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTN
+
@=?DDD;?CFF?<CFFFDHAC83A3C?99CCEC:E??F>??FGCG>DG<;FF>@F@;F8B.=;CFFEAEAE?99=2,5;AB;;8;?<AAA>5<-&00::@#
@89I
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
C@CFFFFFHHFHHJJJGIJIIJIJJAFGHFCHI?FFGGHIGGHIGHJJIHIJJIJIIGIHFHHEEF@ACEAECDDDD>CCDDDDDDDDDDDDDDCDEEED#
@89J
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
?=@DDDADFFFHFEFHGHIIGGIFGBFFGIJG@FHJEFDHIIIHGGIB8BFHIEG@>FHEGG<DCHI>CC=;;3;;?C;?AB;B@@;@?AACCDDDBBB@#
@89K
CTCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
CCCFFFFFHHHHHJJJJJJJGIJJJJJJJJJJJJJIJJJIJJJJIJJJJJJJJJHHGHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDCDD#
@89L
GCTCATGCCTCCACGATCAAATCCCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCN
+
@@@DDDBDHFHHGGIIFIGGHCHJGIGGHHGIGIJJJIJJJJJGHGEIIJJJGEHGHFFFFFCEEDBDDBDCCDDDDDAAABDDDBCCDDDDDCDD?CCD#
@89M
TGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAA
+
CC@FFFFFGHHDFHFIGJJIJIJJJIIIIFIIIGIIJJHGIHIDHIGIJJJIJJJIJJIJGIIIIJIHGGHFFEEFEEEDBDDDCDDDCCDDDCDDBBD
@89N
AGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
;??DDADDFDDFFGGGBGGIDEFCCA:CEHGE?BDEHIABHBFH?FHIHGHDHGGGIIGADAHHHCCEEE?DCCCCB???BBBCBBC@>CCCA<89<<B
@89O
CCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGGTACACACCCAA
+
?;@ABDBBFFBDCEHEG>CF+AFCF?BA<<C9FFHGII4::::B9DF?<F9?99DGHIHIIIIE@8;A@(..=@BE>ACCA6>C=?B&&&+4(()(&(+
@89P
ACCACTTTCTAGCAATGGGAAGCAACCTTCTGCCCACAGATCACTGGGATGCCCTACGGTTTCACAGCTCTGTTCTTGATTTTCTTTGGACCTCAAGGGGN
+
@@?DBDADF?FDHIBBBFGIIG<HCGEGEGGGBBEG;DHGG@FIIIIIHCH>?BGHGIGIIIIIEG7C:AEDBD@D?ACCCDCA@CCCCCCC?CC::>1'#
@89Q
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
@@CFFFFFGHGHHJJJJIHIIIJJJJJJIIJJJJJJJJJIJJJJGJJJJJJIJIJJIJJHHHHHFFFEEDEEEDDDD;@BDDDDDDDDDBDDDDDDDDDC#
@89R
CTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGN
+
CCCFFDDFHGDGHGGJJJJGHGHIIJJJGIJJJGGGHIHGGHFFGHGGEEHIIGIJFIIIJFCGHHEHHHHDDDFFFFEECAEDCDCCCDCCDCDDDDDD#
@89S
ATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAATGTTGGGATGATTAAATTTGCTCATCAGATGTGCCTCCTN
+
@@@DDDFFFFHDHIIJIJAFIGIIJJ@EHIJJIJJJJJJJJJJIIIIJIHJJIIGJIIGIGGGCHGIIIEEHGHHFDCFFCFECEEEEEDDDCCDDCDDD#
@89T
GCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCN
+
@@@DBDDDHF3CFEGGHHIGGGG?BFGE?CCBD><BGEE>D?FBFE@B?BDDDE@;CAFG@GHGAEA:ACB<=A;CCC>A@@@CCAC@?<<??:CC<9?B#
@89U
CTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGN
+
CCCFFFFDHHHGHJJIJJJJJJJJJJJJJJJJJGJIIJGJJJJJJJJJJJJJJJJJ@EFBFFEEEEDDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDD#
@89V
CTTCCCTTGGCATCGTCGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGG
+
@@CFFFFFHHHGHIIIJIJJJIIIJHIJIIIJJIIIIJJJJIJHIJIJJJJIIJJJHHDDDDDDDDDEDDDCDDDEDDDDBBDDDDCDD>ACDDCDDDD
@89W
ATGTAAGCCAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCN
+
CCCFFFFFHHHHHJJJJJJJJJJIJJIIIJHIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJHHHFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDD@BDD#
@89X
CCACGCTCAAAAGTGCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACAAGACN
+
@C@FFFFFGHHGDGEHIIIIHHH>HHIIIIGGFHG?F?DHFHIIIGGFHIICHIGIIIBHGIJIJGGHE@?EDF89;3>CCCDDD?BAACDDDBDBDAC9#
@89Y
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
CCCFFFFFHHHHHJJJJJJJHIJJJJJJIJJJJJJJJJJIJJJIHIJJJJJJJHFCHHFFCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDD#
@89Z
CTTGGACAGATCAGGATCCACCCTGCCTTCTCCTTGGGGGCCATAAGAATGAACATTCAGTGGGCAGGTGTCCTCGCTGACCCTTAGTTGGAGGCCAC
+
CCCFFFFFHHHHHJJGIGIIGGIGGHIIJIGGEHGHIHEHJJJGGI=@FCCHIIGGHEHHHFFFFFDD.;@CDDDDDDDDCDDDCDDCDDD<?B@BDB
@8A0
GTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTN
+
CCCFFFFDHHHHHJJIJJJIJJHJJJJJJIJIJJJJJFHJIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJHHHHHHFF?BD@DDDCDDEEDDDEED#
@8A1
GTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGA
+
@B@DFFFFHGHHHJGIHJJ<FHHIJJIIIIFCHIJJJJJJJIIIJGIJIIGIJJIJIJGHHHHHFFFFFFFEDCEDBDDCDEEECDCCCDDDDDDDDDD
@8A2
CAAGCATATAGACTAAAATCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTN
+
@@?DDDDD8DFFFF<CFABG?<CE?F<<C7CFH>GEFFIEG6:6BF><D/874@F6@7==.777AEFD4,,(65>>;(3/:,:A5(((05&5>02<91<A#
@8A3
GGATGAGATTCAACATTGGGATTCTCCATTGGTGGGCAGCAGGGGTGGAATCTACTCTGGGGCACCCACCTTTAGGGACTGGCAAGTGGGGTCAGATGGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJIJJJJJHIIJJJIIJJIJJBFHIJJIIJJJJHHHHFFFDDDDDDDDDDDDDDDDDDDDDD>CDDD>BDCDDDDC#
@8A4
CTCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTN
+
@@@DDAD?:CFH?E?FGGIIGAGHGEGHIEGIEEGGDBBC;HHGIBFDFGGCEG@F@FGA@737<?9CC?<@CCC>A@(:@?BCC3:+:C::??@B(+4>#
@8A5
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CCCFFFFFHHHHHJIIGJIJJIHHIIIIJGIJJJIIJJFHJJIIJJBFHIIIJJJIJ@DHGHHHHFFFFFEDDEEDDDD?BDDDDDDDDDCCDDDDDDD
@8A6
GATGCTGTCACAAATGGAGGTGCAGGACCCTCAAGGCCTCCACAGGGAGTGCCCGGGGCAGTCGAATTGAGGGCAGTCTGAGTAAGGATAAAGTTCTG
+
@<;?=DD=2CA:+AC@<@9FF::<<3+CEE):CF<?D;*::BG<)0?BA7=<8@@4;=BCCCC?1(5,,:(,(,,3+(4(+((4444@A3::(4:@B:
@8A7
CGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
CCCFFFFDHGHHHJJJJJHIJJJJJJJJJJJJFHIJJJJJJJJJJJJJJJJJJJIJJJJJJHHHHHHHFFFFEEDEEEACDDCCDD8?@DCDDDDDD?BD#
@8A8
GAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTTTTTTCTTTTCCTTCTTGTCTTTCTCCTTTTTCTTTGGN
+
B@BFBDFFHHHHHJJJJJJIJJJJJEHIDGFHIIIIIHIHHIJJJJIIJJJJIFHIIJJJHIJJJJHCEFFFBBCECEEDECDDDCCCCDDDDD?CDDCC#
@8A9
GCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCN
+
@@@BFFFFHGDHHJIHHJIJJCFGIHHIJIIIFGGIIJJJJIIIJIJJGGIJJHHHHHHFFFDDEEEDDEDDECCDDDDDDCDDDEDDDDDDCDBBDD@D#
@8AA
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@@@FFDFFHGHFHHGIII@FGGFGHGIJIBFHGIGFHIIIGEIJJJJIGIGGEHFHHHHFFFFFECACECACDDDCDCDCCCCCCDDCDCCBDDDDDC>
@8AB
CGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCG
+
CCCFFFFFHHHHHJJIJJIJJIJJIDIIJIIJIIGIIIIGHIIJJIJG@FIJJIJJJHHHHHFFFFC@BCDFDDDDDDDDDDDDDCCDDCDDCDDDDDD
@8AC
CTTGTTCTTCAAGCTGCTGTTGATGATTGAGGATCTGATGTTTGGCTTGTAGTAAGTCTGCAGCTGTGCTACTATGAGTGCTGTTTCTCAGAGTTTCACTN
+
=:?D4A:4CDA<A+<CCE9F:C@9EC,,<<CA?+@:C**:??C*:?DDIDBB?B*9?DDD<*.=8<=@C4@;ACD@)===AD=ACDD?7@)7?AA@@>@A#
@8AD
CAACAGATGCCCCGCCTCCACTTTTCACCGCCGCACCTTGCCATGCCGATCCTCTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGN
+
@@<DDFDBAFHF?6EEAEGHIIEGEIIIBAHG@FEFHH@FEHG;==CE8?BBECCCACCCCC;>>@>CC?>A@@>?B5>5&2<AB?<?BBB08<<@@>?.#
@8AE
GCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATAAATGGAGTGGCAGCTAGGCACTTCTGAGTCATATGCAAAATCTCTGGGTTCCN
+
CCCFFFFFHHHGHJIJIJGIIJJGJIJIIIIJIIJJIJJIIJIJJGIIIIJHHHEHHFIJJIIJIJBEHGHEEHAD@D;>CECCEDEC@@C>A@AD<?BC#
@8AF
GTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTA
+
@@@DDDDBHADB?FGHDIECFBIHGH@FFA?EHFHFHIEIGDD9BF?B*9?DFHBHEIB@@@;@BADEE@(.6;;5=BBBBBC<:>>::>@3:43:0))
@8AG
ATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATN
+
CCCFFFFFHHHFFGIIJJJJIJ8EHHIGIIJJJJIJJIJJIIGIIEIJJIGGBHHFHFFFFFECCEEAEDDDD>CDEEDDDDDC@CCBDDBDD<A@CCCD#
@8AH
CCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCN
+
@@@DDDDDFDH;FBEEFIIFHFGHIGBEGGICGHGC??FG3CDHCEHHGIIIIGGGIIICFFHGGIIIIIIIIFFFHHEC?DEDEB>36>;C;@ACDD3>#
@8AI
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
CCCFFFFFHGHHGJJJJIJJJJIIJJJJIIJJJJJJJJJJIJJJIIIIJJJIJJJIJJJHHHHHFFFEEEEEEDDDD3=BBDDDDDDDDDDDDDDDDDDD#
@8AJ
CGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCCATCGAATTTTTCTGGGACAACACAGGTGTCATCATAAAACTGCCTGGN
+
CC@FFFDFHHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJIJHHHHHFFFFCDDEDCCDDDFDDDDDDDDDDDDDDD#
@8AK
CTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCN
+
:??BBDDDHHF?FHBFHEF@<@?FGFEFCFB*?D=GFGHGIGEHGIIIIIGEC?>CCEEDEFFBAEEEC@;;>AACCCCC5>AA@CCCCCCCCB>?5>@>#
@8AL
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
CCCFFFFFHHHHHJIJJIJJIIJJJJIJJIIJJIJJJJJIJJJJGFIIJJGIJJJJJJHHHHHFFFABDBDDDDCDDBBBDDDDDDDDCDCDDDDDDDDD#
@8AM
CTTCTTCATGGTTCTGATGCAGTATGACCTCCGGCTGTGTGTGTATAGAGTTTCCAGGGTGGAAGAATGGTGAAAAAAGAATCCGAGGTTTCCTCTGCTTN
+
@CCFFFFFHHHFDGIIIJIGIJIJIIIIIJJJJIJJIEIJFIIHGIJDHIGIIJJJIJJ@FHHIIEHEHH?CCEFFCDDDDDDDDDDD>BDDCDCCDDDD#
@8AN
CGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGN
+
CCCFFFFFHFHHDHIJJEGHIIJJJJJHIJIIJJJJIJJJIIJJHFDDDCDEEDDDDDDEDDDD@DDDDDDDDEDDDDCDDDDDDDDCD>BDD?BDD3@B#
@8AO
GGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGN
+
B@BFADDFHHHHHJJHJIJJJJIJGJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJJHHHGHHFFFFFFFEEEEEDDDDDDDDDDDDDDD>CCDCEDDDD#
@8AP
GTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGCTTTCTGGAGTTTGTCTGTGTATTTGGAGAGGTTGTGAAGAGGGCTGGGGAGAAGGTGATGCTCGN
+
??=D?DDDFH?HD@DHEG<ABADH8CBEGGIG>FCAGHAFGGGDFHHGGHCF@=FFG=FCCA7@=C=G@>EE;7@DEEC>A?BBB5;?9?@3:3:>A>CB#
@8AQ
CTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGGAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGN
+
@?;DDD>DF>?<2AE@:?FF6EAGFAFGA<DBFFIF<DFF9?<;GGFF';AB(.7;3=?;?76@A>A>AA?=@@?BB<9?8,50>:>@B@B@4:>(4:?B#
@8AR
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
CCCFFFFDFHHHHJJJJJJJJJJJJJJJJGJJJJJIHIIIJIJJJJJJJJJJJDGIJGHJJ;EHHHHHHFFF@BEEEEDCDDDDDDDDDDDDDD>BDDDD#
@8AS
GTCCTCTGTTTGGAAACCAGCCCGATTCAAGGAGGGTTCTGATGCACTGCGGTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJIJJJGIIJJJJJJJJJJJJJBHIHHHHHHFFFEEEEEEDDDDDDDDDDDDDDDDDEDDDDDD>BBDCD#
@8AT
CTTCTATAGAATCAGATTGATTGAGTCTTTCCATTAATACCTGATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCC
+
???DDADD?=A:D<:E:<3CFF@:3CAF?CFF<C?421C?::E9D9D1::DE???D??8?BD<98B=)BCA==./@=C@7=)?=ACDD27.;A>3>>A
@8AU
GTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTN
+
@@@DDDFFHHGHHJGIIJJJJJJHJJGJIJGGIJJIIGHIIJJJJJJGIIIJIEHHIIIIFHIIJGGHEHEEHHHFFFFEDDEDDDDEEDDDDCDD;@BD#
@8AV
GTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGN
+
CCCFFFFFHHHHHIIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJIJJJFHHJFHIH;CHFFFFFEEDBDDDDDDDDDDDDDDDDDDDDD#
@8AW
TAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCAT
+
BCCFFFFFHHGHHIJGHIJGJIIAGGGEGIJJJJBGHIIFIIJJIJJJJGJJJJJJAEHHHHHHFFFCFEEEEEDDDDDDDDDDEDEEEDDDDDDDDDE
@8AX
CGGCAAAGGAGGAAAGGAGTTACAGGGTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGN
+
CCCFFFFFHHHGHJJJJEIFHIJGIIGGHIJIIIJIIJJJJIIJHFDDDDDDDDDCDDDEDDDD8@DDDDDDDEDDED>CDDDDDDDDDDDDDDDDD@@D#
@8AY
ATTTAAAAATAAAATACAAACAACAGAAATAAAACAAAGATTCAGCAATTCTCTGTATCTTGCAGAAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACN
+
CCCFFFFFHHHHHJIJIJJJJJJIJJJJJJJJIJJJJJGIJJJJJJJJJJIJJJJIIHJJJJIJJJJJJJHFFFEEEEEBDDDDDDDDBDDDDDDDDDDD#
@8AZ
GTCGGATGTGGCTGCAGAGCCTGGGCAATGCCGTGGAAGTCAAATTTGTAAGCATATCTTTTGCCGTGCACTTTGGTCATAATGTTTTTATCATAGTAATN
+
CCCDDDFFHHGHGJFIIJGIJJJIIIJJIGGGGFHIHIIHIIJJJJJIJIJIGIIGIGHGJJEGFEHDEFDCEEEE=@CDFDDDCDDDDDCDEEDDACDE#
@8B0
CTCTTCCAAGGCCATGAGTCGCTTCTGGACCAGCTGGGCAAGAGTGAGTCCTTCTTCTTGCTCTAGCTCCTCAATTAAGGCCAAGGGATCTCTCTGTTTTN
+
+:?D1=BB?FF8ACD<::AAC::81EF9??CF8;C<F1?318)??*99B<8=B)7=)87)8).).)7=?=3=))7?B;@AC9==?;@??<33((,(,,:?#
@8B1
CTCTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAAC
+
C@CFFDDDDHFDFGHIJJGIJGGIGIIGHCFHJGGIGGIJCIGIGIGGIGIGHECHIEG>FHA@CEGHC=7A>CEHEECB>@@@C>CECCDDDAACC@<
@8B2
TACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJIJJIIJIJJJJJJIJJJJJJJJJJJIJIJJJJJJHHHHHFFFFFFEEEEEEDDDDD#
@8B3
GTCAAAAATTACAGATTCAATTTCAGCAATTACAGGCTAGTGAAACTCTGAGAAACAGCACTCATAGTAGCACAGCTGCAGACTTACTACAAGCCAAAC
+
@@?D=DBBHAFA>:AFHBDEI@HBF<<B?BBE@H3)?)?C1CFHF<DDF<?FHFFHC38B8B;==CHFEHG:7CE@7?;===?CEEDE@@CC@?;=CC?
@8B4
AATTTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAATGGCN
+
CCCFFFDEFDHHGJJJIGHGIJJJJIIJIJIEHGIEHIIIFHEGGIGIIJJJIIJJJIIJJJJJJIDHGHFEFFEFCEDEED@@B=ADDDDDDCDDCDDD#
@8B5
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CCCFFFDDHHHHHIJJJJJJGHIJJJJJJJJJJJJJJJJIJJHIJIJJIHIIJJJJIHIJJIJJIJDHHJEHHF@DCDCEEDCDD8?CDDCDDDDDDDCD#
@8B6
TCATCCTTTTCTCTTCTTGCTTGTTGTAAATTAGCAGTGAGCTGGGTTATAATGCCATCTCTTTGTTTAATGGCAGCTTCAAATTCTTGTAACTGCTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJIJHJJJJJJJJJJHIJJIIJJJIJJJJJJIJJJJIJJJJJIIJJJJJIIJJJHHHHHHFFFFFFFEEEDEEEDDD
@8B7
GCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJHJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFFFFEEEDEDDDD#
@8B8
CACAGCTGGATCTGCCCGCTTCCAGGGTTGGCTAGGCGACTGCTGGTCGGGCCCAGGATCTGATACGGATCTGGCTGGGGCCGTTGCTCTGTATTCTTACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIIJJJJJJJJJJJJJIJJJJIHHFDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDEEEEEEDD#
@8B9
CCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAA
+
CCCFFFFFHHHFFIIIJJJHIJIJJJJJJJJIJIJJJJIJIHIJIIJIJ?FHIJH?CDDDDDDBDDDDDBDDD>BDDDDDEEDDDDDDDCCDDDEDDD
@8BA
TCTACAGTAGTTTTGCTCCATATAAGCATGACTCCACCTGAGTCTCCAGTAAGAACATCTCCATTCCCCAAGAATGCTAAACACTGCACAAATTTTGGCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIIJJIJJJJJJJJJJJJIJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEEEDDDDD#
@8BB
ATCAGATGTGCCTCCTTCAGGAATTCAATCTTCTCCTGGTCTGTGGAACCCTTCTTCAAAGTCTTCACTGCTACTTTGATTTCTCCACTTCCAACTCCT
+
BCCFFFFFFHHHHJIJJJGHHIGIJJJJJJJJIIJJGIIIIJIJGIIJIJJJJJJJJJJJJGHIJJJIJGGGJJJJJIFHHHHHHFFFFFFEEEEEEDD
@8BC
GGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGN
+
8?<DDDADA?DBFCEGEGGHIDEHGIIE?GEH6DDDGGHDGIHGGAF=BCFHGI=DGEECCAHEEBE@>@ACACCB@3;:5:@C>>C?<5?<ACC:@@@>#
@8BD
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
?=?BDDDDCDDD?EID:EE:F99<FC@E=<30:0:B@9*BD@DDD;3<)/=CA).@2)@CADCDD???@A@>>??A?(:>A>A????53>>A>44>>44:#
@8BE
CTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGGGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCN
+
???D7D8A:?BDD9E@EEF4AFB:FA<<32AC1CEDD;DEE>BD99BBDCEID0B=B(5/7<?(((4+<3<>(+:+:A:+444<<><<>A><>?0)2>>4#
@8BF
ATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTN
+
CCCFFFFFHHHHGCGHJFHJJJJJFHGGIJIJJGIJJJJJJJIIJIJIJJJJJHHHHHHFFFFFEEEEEDDDDDDDDEDDDDDDDDDDDDDDDDDDDDD>#
@8BG
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGN
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJJJJJJJJJJIIHJJIJJJJJJJJJJJJJIHHHHFFFDDDDDDDDDDDDDDDDCCDDDDDDDDEDEDDDDDDD#
@8BH
CATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJHIIJJJJJJIJJJJGHIJJJJJJJJJJJJJJJJJJJHIJJJJHHHDFFFFFEEEEEDDDD?CDDDDDD5?BDCDDD#
@8BI
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGGGGTCTGTGCATATCCTTGAGTGGGCTN
+
@=@?DDDD;ADAH+AFHEEIFBA@?FC<HCA9;???@?FG><BG@FFGAHGCGGG4D?=B==C>@=;CDCCC;'5505?CCCA@D4>C>@CA:::@?103#
@8BJ
CTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGAAGGTGTN
+
@CCFFFFFFHHHHJJIJGIIJJJJIGHIGHIHIHGIIJJJJJDFHGHIGGHIIIJFEHJIJHGGGHHGFFFFEEDEEEDDDDBBDDDCCDDCDDDDD9AC#
@8BK
GTCCACGCCAGCTATCTGTCCAGTTGCAATCCTAATTTTGTCAGGATGTATAGCAAGGCATTTCACACAGTCTGTATGGCCCAGGTAGTGTCGCTGAGTTN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJHHHGHHFHHFFFFDDAEDCDDDDDDDCDDD#
@8BL
CTGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGN
+
@CCFFFFFHGHGHJJGGIJJJIJJIJJJJJJIJJGIIIJJIJIIJJJJIJJJJJJJJJJJJJHHA@C>CDDDDDBDDDDDDDDDDDCDDCDBDDDBDDDD#
@8BM
CTGCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTN
+
@CCDFFFFHGFHHJIJJIIJIIGIGIHGIIIJIGJJJJGGGIJJIJJJJJJJJHHIIJJJJJJIIJJJJJJJIJGJGHIGJJJJHHHHFFECDFFCEEEE#
@8BN
GAACACAGCTCATTGATGTAGCTCAGGAGACCTGGATCTGGATACATCCCTTCCTCCTCCTGCTGCTGCCCTTCTTCCTCTTGTTTTCCATCTGACTCCCN
+
CCCFFFFFHHHFHGIJJIJJJIFJJJGIJJJJJIJIIIJJJJJJIJJJJJJJJJJJIGIHJJJJIJJIJJJHHHHHHFFFFFFEEEEEDDDCDDDCDDDD#
@8BO
GTCTGTTTTAGAAGTGAATATTCCTTCCATGAAGGCCTCTGGGGGCATCCACTTAACTGGCAGCATGGCACAGCCTCCCTTTCTATAGTAGCTCGCCCTGN
+
;?;BDDADHHDHFG2AEBHGIF>FEEHEEC<?FHHIEGGICGH86?DBB8F>F;CF@@77@>DEFCHEDE;;6==>???C>C>AADC@CCCCCCBB>@<@#
@8BP
CTTTTGTTGCTACTCTCCTGAACTCTCTCACTCATTTGTTTCAGTGGACAGGAAACGCACCATATCCCCCTGCCTGGATGGGTGTTTTTGGAGAAGCAC
+
@@CFFFDFHFDHFIIIJDG>FFHEHGEHHGHHJEGEII?CGEFHGDGDCHIIJIGIIGBFHEIEGIECGEE?=DC>AECCB;(3;BCC@BB><CBCC??
@8BQ
AGGGAATTCCCACTTTGGATCCTCCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCN
+
@@@DDDDDDAF?DD<AGICACG?HH?GCEBEC??EGHGD9DHB?00?9:9DGI;7?@4;8;E;46@;;@;6;6@@A>;>@>;>CCC:;:>@AC>>C;:@D#
@8BR
CCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCN
+
CCCFFFFFHHHHHJJJJJIJJJIHGIJJJJJJJIJJJIIIJIJJDGIIIJJGHGHJGIJHIGIJJJJJEHHGHHFF;ABDCDDDCBD?BDDDCDDDDDDD#
@8BS
CTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGN
+
C@CFFFFFHDHHHI>FGGHGHJJIEGEHCIEIIIIHIJJIGGGGCH?DHBGEDGGFHIIGIIEAAACEHFEFFEFCDDCCCED=CBACB<ACDC@CDDD@#
@8BT
CTTCATTAAGTTTACTTTCTTGTTCAGCTATTGTCTGTCTAGCTCTCTGAATCTGTTCCCTTGAAAAGCTCAATTCTTCAACAAGGTCTTCAAGCTGTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJIJJJJJJJJJJJJJJJJIIJIJJIJJJJJIJJJJJJHHHHHHFFDFFFEEE#
@8BU
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTN
+
?@@A=BD;FAH@DFGEEECH9D1?A=AFDFH2(BFFGHGGCGCF@@@GGEHIDEECA;B:7;@36>>;@A@CC;@;3>ACA?AA?'+0>BCCCCCA@4::#
@8BV
GGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTC
+
@@;DDA@BDFF?CGGGH<???CFGFF<EHEDCCC?FF?F?D?FBEHIGGGICHIGGIIIII:D=@DD=CHEAA@?)?7;?9?;=5;@CB,5<8@3;@35
@8BW
CTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGAT
+
???DDD8DDDD:A4:2<3+3++CB@EB:+2++1:BECD?>DEA1?)9?@9BDD3=BBCCA:=A@C))5(==>;@;@1)..;(6>3,>>(5((9,::>((
@8BX
GCTTCATGTTTTAATTCTAGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTA
+
CCCFFFFFHHHHHJJJJJJJIJJJJJJJJJIJJJJJJJJIJJJJJJJJJJJIIJJJJJJJJJJJJJJJJJJJJIIJJJJJJJJHHHHHFEFFFFFEEFE
@8BY
CTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTN
+
CCCFFFFFHHHHHJJDDDDDDDDDDCCDCDEEEDDDDDDDDDDDDBDBDDDEDDDDDDDDDDDEDDDDDD@DDDDDDDDDDDADDDDDACDCDDDDDCCD#
@8BZ
AGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTGAGGCATGGTGAGGACTGAGGGG
+
;??:A?DDB>CAF?<E<BHHI6:EBGIEG@9FH@EGGHEBG6@FE?8?C;@FEGHGCGHE7AEEBDE>A3>C@(;;@@C@B@C?<>>:9A+8>A>48?B
@8C0
CTGCTCTCCGTATCCCCAGGTACTAGGGTTTCTCCAGGACCCAGGGAAATGTTGCCCCTGGAGCCCAGTCCCTGGCAGCCTTCCTGATACTCAGTTACACN
+
@@@DDDDDFFCCFGIHDEAF3<9F>@EAHE=FBGHBG9DG9GH?CDGIB>FDG4@@FGGH;=C;;;?=BCB@CAC2=BBB?>@AAC<A>@ACCCCE@@@C#
@8C1
GTGGCCAAGCCAGTCCATTTTCCACCTTAACAGGTGAAAATTTAAATCCCAAATTAATCTGATTTGTGGCAGTAAAGGTCCTTAAGTGCTTTTAGCTCCTN
+
CC@FFFFFHHGHGIHIJIJJJJJIIIJIJJJJEDCDGHIGIIIJIGIJJIJJGIIIJIJIGIJJIJ@CHIIJHGHHHHCEFEFFFF?CCDEEDA=C@CCC#
@8C2
CTGCGGTCTTGTAGGTGCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGN
+
CCCFFFFFHHHHHJJFHIJJIJJJIJJJIIJJJJJJJJJJJJHIJJJIJJJGJJJJJJJHHHHFFFFFDDDEDDDDDDDDDDDDDDEDDCDDDDDDDD>C#
@8C3
GCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGAATN
+
?@<;D?>DDAFA:AC+A<AFFFHCE<A?43++A2?FF@C<4?C?4C:?::?BG>FGE3??FG@BFC<8=;=F73@3.(.=(..=772.);66;;6;(;5-#
@8C4
CATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGG
+
CCCFFFFFHHHHHDHIJIHIJJJ@EHHIJJJFHJJJJIIIJIIGIJJJJJIIJGFHFDCFEFFEEDDCEDDDDDDEEECDDDDDDCCDDDCDDCDBCCD
@8C5
GTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTN
+
CCCFFFFFHHHHHGHIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJCHFDFFEDEEEEEDDEEDDDDCDDDDD#
@8C6
TCCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTN
+
CCCFFFFFHHGHHJJJEGIHIJJJJJJJJJJJJJJJJIJJJJJJJIJJJJJJJIHHHHHHFFFFFEEEEEFEDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@8C7
GGGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCN
+
BCCFDDFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJJHIJJJJJJJIJJJJIJJIJIJHHHHFFFFFEEDDEDDDDDDDDADDDDDDDDDDDDCCDD#
@8C8
GGGTTCTTGAGCCCAGCACTGGGTCATTAAATTCCACAGATCATCAGGACAATTTCTTGGTGGCTCCAGTCTCCCTCCTGTTTGCACATAGTTTAACAC
+
?<8DD>=D:22A<<E:E:<FD?;2<<<F?CEC??9D9?8:0?D?0B?3DB?899D8DE=)BCDC9C;==77?=CD9;;;;.66((6.5555----55(:
@8C9
ATTAATCTCTTCATGGCTTTTGGACAGTTACTCCGTACCTTACTGAGATCTGGAGACAGGTATCCTCGTCCCACCATAAAAATTATCTGGTCCCTGTTGTN
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJIJJJJHHIJJJJJJJHHEHFFFFEEEDEEDEDDEDDDDDDDDDDD#
@8CA
CAGGTCTTCCCGATGAGAGAGGTTGATGGGCTTCCCTTCCCTATGCAGCCCGTCCTCGGAGAGCCTGGACTGTTTGAAATCCACGGAGTGCCGGGGGTTCN
+
CCCFFFFFHHHHHJJGHGGGHIHGGGGIICGIJIGJJIJJJJGIIJGGIIJIIGIIIIFHDDBCECCCDDDDDDDDCDDDDDDCDBDD@BDDDBDDD5@D#
@8CB
CCTTGCCTCTCTCTCCTCCACGGTCTTAGGGATCCCAAGGAAGAGAAGTGAGTGTGCGACCGAGCTCAGGGCCCAGGCTGGTTCATGCTATTCTTGCTTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJHIIJJJIJHFDDDDDDDDDDDDDDDDDDDADDDEDDDDEDEEEDDDDD#
@8CC
GTAGTAGCTGCCTAAGTGTGAAGGCACGTGGGTGTTAGGATGGCGGGGGACGTTGGGGTTGGGGTAGATTCCCCCCGTGGGGGAGGTCCAGTATTGTGATN
+
B@BFFFFFHHHHHJJJHHIGIJJJJJJJHHJJCFGHJJJHIJJJJJHDDBD@<BDDDD7@DDDD5@DDEEDEDDDDD@DDDDD<BD<CDDDCDEEDACDE#
@8CD
GTCTTTCCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATAC
+
@@@DDA:=A?F;??E>E<AA?BCDFHBAE?F@E@B9:??F>?<?>@F>0:0?F?99D;@?=F@FFFAAC;=>=CE@7==?===?;B@>?;>B6;@@B>A
@8CE
CATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTAT
+
=8+:ADDDFBFBFBBADFFFIF>EHEEFAGDFFF*9CGDDF@DFGEBG0??FF;A66;8<3,9>;--;;;?:533>A<@9:3:05&009ABBB<<B@>:
@8CF
CTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTN
+
@C@FFFFFHHHHHJJDBDBCDDDDDCCDCCDEEDDDDACDDDDDDDDDDDDEDDDDDDCDDDDEDDDDDDDDDDDDDDDDDDCCDBDD@ACACDDDDDDC#
@8CG
GCTTCTGGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATN
+
BB@FFFFFHHHHHJJJJJJJJJJJHIIJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJIIJIJJJIJJJJJJIEHIIJHHHFFDABDEDDB@BBDDAFEAC#
@8CH
CCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTN
+
=;?;=BDD?A<00CF8?BEGEH:?F?=B0?8DGBG>@DGFHAAFGGGGHAHGHHB=?ECDBDCBC@6>@@;;ACAC;;>@CC::?B8992>C>?CC:>>4#
@8CI
GCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTG
+
1:==AADDHFHHHEIJGHHIIGIJJJJJJIJJJIIJIGIIHHGHIJ?DHIJI>BDDEEDBDDBDDDDDDDBDDDDDDEEDDDDDDDCDDDDEDCDDD@C
@8CJ
GCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCAT
+
@<@DD?AB>FBHFIIIIABCHEEB@FEGGGHEGIIGDF>FGIDDFFGGGGI7@/@5=CEH>E7?BBB;A?BB@CCCB?:?CCAC>ACCCCC<AA@C>A
@8CK
CGGTGTATGAGTTGAGTTTGGAGATGCATGATGCAGTGGGGACACTGGCGTGCTGGATGGTGTGGGGGGGTTGGAGGGCCTCATTCCCACTTGTGGCTTCN
+
@@@AD=AD?HHDFB@EACCEGDGHGHHIIGGGIIHCHIGIIBHHGGFDAAA:8CGC@DDGHF;AE?>?B@5>BBCCBB@BBBCCECCCCABCC>CBBBBC#
@8CL
TTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
@@1BDD>DBHDFFIHIIIIFIG@CFEHEDHIIGIIIHGGIIIBADBBGEGEIIE==BD;FHG>87@D<EHHBCCBBCCC@@C3:A?9?B<?ABC:>BAAA#
@8CM
CTGATCAGGAACCTCTATTTCTCTTTCAGGATTCAGATCATGATCCCACAGAATTATTTTTCTGTCTTTCCCTCCTCCAGTTAATAACATCCC
+
CCCFFFFFHHHGHJIJJJJJJIIJJJJJJJJJJJIIIJJIIIJJJJIJHFGHIIJJJJJJJIJIIJIJJJJJJJJJIJHHHHHHFFFDFDEED
@8CN
GGCAACACAGGTGTCATCATAAAACTGCCTGGGGCCCTTTTCAAACATACAGCCTTCTGTTCTGCTGGGATGAGCCAGGAAGCCTTCTTGCCTCATATA
+
CCCFFFFFHHHFHHIJIJIJJIJJJIHIIJJJJJJJJJJJJJJGB9??BFHHIJJJIJIJJJJJJJJJHHHHFFFFFEDDEADDDDDDDDDDCCDCCDE
@8CO
CCCACCCACATTCTATTGGAGATCTCTCAAGACTATAAGAGTAGGGAAGAAAGAGAAAAAATACCTCTTCCTAAGAATAAAGGATTCCCCAGATGCCA
+
@@@FADDDHDHHBIHHHHIIGIJGIHAGHIEIJIJJGGIBH?BGHEGGHGIGGIIIIJIJIGIGEHEHGHGFFFDFFDDEECCB@CCDDDC<B::>CC
@8CP
CTGCTTTCTTTGATTCTTCGGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCN
+
@C@FFFFFHHHHHJJJJIJIJJJJJJJJJIJJJJJJIJIJJJJJJJJIJJJJGIJJJJJJFHIJJJJJJJJJJJJJJHHFDDDDDDDDDDDDDDDDEDDC#
@8CQ
GGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCATCTGCATGGCTTGCAGCTCCTGGTGCTTCCGGCGGTACACTN
+
CCCFFFFFHHHHGJJJJGHIJJJJJJJJJJJJJJJJJJJJJJJIIJJIJJJJJJJJHHHHHFFFFFFACEEDDDDDDDDDDDCDDDDDDDDDDBBDDCDD#
@8CR
CCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGN
+
@@@FFFFFHHHHHIJIIJIIJGEIJIICHGBGGICHIJHGGFHHIJJIIIJJGIIAGGIIJJJHHHHFFFFFFDCCB;@BDD>CCDCDCDDDDDBDDDCD#
@8CS
GTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCN
+
=??DDDDDHHHHGJJJIJJIJIIIIIJIJJEIJJIGJ?GHIIIJIIII>GHGIFHHHGIHHI7@EHCECEHFFFFFDCEEE>CDDDDDDDDDACCD<CD?#
@8CT
CTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGN
+
@B;DFFDFHHHHHJJJJJJJJJJJFJJJIJJJGHFHIJJJ9FFHGIGIGGIIJJIJJHGIJIIJIIIIEIHHEFFEECCE>CBBBDDDDDDD9@CD5?BD#
@8CU
CTTATTCTCTGCCAACAAACTACTTTTCTCTTCCTGCAATGCTGCAACCTGCATATCCAGTTCATGGCATCTTTGAGCAATTTCTTCCTTTGCTGACAA
+
1+144B:B?FDDFIBDF@E93A:3<<A<?<<4?91:1??*?B:DB::0B*)))*/9***/=)))/88==)87=7@)@=CE:=777);;?B6(.6>(,((
@8CV
TGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTN
+
C@@FFFFFHHHHHJJJJJJJJJIIIIEIGA@GHHHGIIHHFFFDEACC>CCDACDEDDCDDDDDDDDDDBDDDDDDDACCCDDDDDDEDCCDDDDDDDDC#
@8CW
CATTGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTN
+
??:AD::AFBFHAGDGIAEICHHG@C?@FEDGGIGHIGGIGGBHGEGDGGHHGDHGGEIGG=@@=@@EHAHH?C?CCEC33@C=;;ACCCBCAA:ACCCD#
@8CX
GTCGGAATGAACTCTGCTGCCCGTAGCTGATGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
@?@DFFFFGHHGHJJJJJJJJJIJJJJJJ@GIJJIJJJJJJJIJJJJJIJIJIGIIJJIIIIIJIJGJHHGFGFFCDEFDDD9?BD@CDDDDDCCB?BBD#
@8CY
CAAACGTGTTGCTGTCAATTGGCCTTAAAGAAAACTCATTTTCAGCCCACTTGAGCCACTGGGCTACGTCATCCCTGCTCCAGTAAATTGGCTGCAAGCGN
+
@?@DDDDDDFBHHGBEGHHHEDCGH@FHBHC@C;FGIIGIEGFH9BF6)?BDG?F:BBCHCBGGGGHA=AHAE@B>;?;@C>@;ACCDDCCC>@@CCC??#
@8CZ
CTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGN
+
CCCFFFFFHHHHGJGFHJJJJJJJJHIJJJJJJJJJJJJJJHIJJJJJJJJJJIJJIJJJIJJJJJJJHHGHFFDFDCCDDDDDDDDDDDDDDDDDDCDC#
@8D0
CCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTN
+
@CCFFFFFHHGHHIGJJIIJJJJIHGJJJIIJJJJJJJIJJJIJJJHIJJJIJJJJJJJJJJJBEHFCEEEEEDCCDDDDDBBDDDCDDDDDDCCDDDDD#
@8D1
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@CCFFFDFHGHHHJJJHHIJIIJJJJJIJJJHHIJJJIGJJJIJJJJJJJIJJGHJIJJIHIGGHEHGHFFFFFFEEAEEDCDDD5?BDCDDDDDDBBD
@8D2
GGAATAACTGCTCGAGGGCTTGGTTGGCCTTTACTTGAGACTGATTTTTTCACTGAGGCCACATGATCTTCAGAGATTGCAAGACGCCTCAAAACATC
+
@@@FDFFDFGHDHJJIJFIIIJDHIJIGGGHHGGHGIEE?GGGCIJIJJJGGIJG@DHHHFFFFDECCEEEEDDDCDCCDDDDCC;=B?BACDDBDCD
@8D3
CACCCGTGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTN
+
CCCFFFFFHHHHHJJJJCGHHHIJJIIIJHJJJJJIJJJJIIJJJJJJJJHHHHFFFFFFFEEECEDDDEEFEDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@8D4
CCCCTCTTCCCCTGCCCCGGTTATCAGGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTN
+
CCCFFFFFGGHHHIJJJJJJJIIIIJJIJJJJJIJJIIJCHIIGHHJJIIJJIHGHHHFFDDDCCDDCDDDDDDDDDDDDDDDDDDDDCBDDDCCDDDDD#
@8D5
CTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATN
+
CCCFFFFFHHHHHJJJJJJJIIJJJJJJJJJJJJJJJJJJJIJJHIJJJJJJJJIJJJIJJJJJIIJJJHH9ACD?CDDEDDCCDDDDDDDDDDDDDDDD#
@8D6
CCAAGGAGTGCCTGCTCATTTCAAACAGGAGCCAATGGTGCATCCAGCTCTCAAAGACCTTCCAGTCTATGGTCTCCATGGTGTTCTTAAGGTGTCTC
+
CCCFFFFFFHHHHJJJJJJJJJJJIJJJJJJJJJJJJJGHIJJJJJJJIJJJJJJJJJIJJJJJJ8CHHIJJIHHHHHHFF?CFDEEEDEDDACCDDD
@8D7
CGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGCGGTCTGGGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCN
+
???BA:+2AD><<<+<+<CC9:CAECFF;B>9?BE>DF@DFD9:))-'-'=)=CD=??;A7?A;.(.,=;(,'(,89&)&++:::+4>4:4+:>3+(4(:#
@8D8
AAAGTTTTTAACTCTTCTATTAGAGTTTTATTTTGATTTTCCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTN
+
=?1A=ADDFFFFFF?ACFCEHEH@FCHEEEI@HF??FGIIEDEE@?DGFGFGIFEEE6AFFEEEGDDFIIFE@EEFCF<:A>BDDDDACC@>ACB@?BBB#
@8D9
CTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCAT
+
CCCFFFFFHHHHHJIJJJHIJJJHJJJHHIJJIJJJJJIJJJJIJJJJJJJJJJJJJJJJGEFHHHHFFFEDED;ACDDDDDECDDDDDDDDDDDCDD
@8DA
ATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATN
+
@@@DD+A;FHFHBDE?CF<BHA?A@FAAFEHICHGIEEHHEDHGGGIIEFGHEGHG=<CCFGGIIIIIGIGDHIBHCHEEDCDBDC>>@;C<9>@CDDC>#
@8DB
CTCGCTTCCCAGACTTGGCAACAGGATATGGAAGTTTGCTGGGGCCTTTTGCTCCAGCAGGGAGCAGGTGGGATGCTCTCTGGCTGCCCTGACCTCCTG
+
CCCFFFFFHHHHHJJJJJJJJEHGIGIJJJJIJIHIJJJJJJJJJJJJJIIJIJJIGJJJJJJHHHFFDFDDDDDBCDDDDCDDCDDDDDDCDDDDDCD
@8DC
CCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATN
+
@@7DDDFFHGHGHFFCHIIGIJIJJJJJCFHIBGHIGIJIJ<BFHHJJGEGGIHIJGB=FHIJIIIJJJIGIIJHHHEHFFFFFFDDDCBBBCACCCDDD#
@8DD
CCTAGATGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCTCTCCTCTCCACACCCAAGGGTCCCGGAGTTCCCTGTGGAGCTGCA
+
CC@FFFDDFHHFFEGIJJIJEHHIEEHIIJGGCEGIIJJJJIGIHIIIEFHJJGICGHGD=GHJIIEGGHFHHFEFFEDCBBDCCDDCC>CCD<?BCDD
@8DE
GTCATATGCAAAATCTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGCAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACATTGGGN
+
?1=?B>DABD<?D@EC,AEEDCF@>CC<AE<E<94?4*:*1C?DDDD?'5AD@9?A>;;;??@9'9;?:A(5:>190(((+48<+((3+(44>(((++4+#
@8DF
CTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACAGTTTGTGGCAGAGAAGTAGCTGN
+
@@CADDFFAHFDHIGGECIIIEFH?FFHC@FGCDGH@GGI@AG??DFFG=BB8=@HH@DHGCG=E>E?C>;;@@C>AA>6@AC;=?55855<?C(:AC>C#
@8DG
GTCCTCGCTGACCCTTAGTTGGAGGCCACAGTCATCTTTAACATCTAGTATGTTGACAGGTTCTATGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGN
+
CCCDFFDDFFDDHIDHGHIJIGGHIIIJJJFFEGGCHIJJJIJJJJIJFCHIHHJJGGGGCFGGGHJJAHHFHHECBBCB?BCDDC?C?ADCCCCCCAC@#
@8DH
CCTAGTTCTTCCTTGAGTTTTTCCTTTTGAGAGTTAGTATCTTGCAATTTTATATTCAGTTCATTTATTGCCACATTCATTAACTTTATCTGATCTTCATN
+
BB=DDFFFHHHGHIJJJEHIJJJJJJJJJHIJJJIIIJHIIJJJJJJJJJJIIIJJJJJJIIJJJJIIIIIIJJIJJGJIJJJIIIHHHGFFHFFFFEDE#
@8DI
GTGGAGGATGGATGGGGAGGGACAAAGTTCACCTTCTGCTGGTGGGCATGGTAGGAAGGCATGTAGGAGATGTCAGAAGGGTACTTGTACATGGACGACTN
+
CCCFFFFDHHGFFIJJJJJJJJJJJJIHIJJJJJJJJJJJIIHGIIJIIJJHJIHHHHHFFFFEDEEECBDCEDEDDDDDD9?CDFDDCDDEDDDDDDDD#
@8DJ
GATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGN
+
?@=DDDDDHHHHHFGGEE9ACF@EGGGHEHIIGEFGCDHGEGF@DHCDFHGEGGIICGGDAFH@=@C=@;>CHC;@DBB@BCEA?=ABBACCCCEECBCC#
@8DK
CCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGT
+
@@;DDEDDHHFCDGFGHGEIGIGIHFEIGIIIJFHIGGHI@G?DFCBFFHABFCFIICCFH=@EGCEAE@DEDBAC,=@CCCCDDDDBBCBBCCDDDB5
@8DL
TATTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGN
+
??:AADDDHHDDDEBBGFBBEGGIEHIGGIGEIFGDHAGIGGGGI@A;FGHIEGHIE==AEHE;?@;@;;6>@CDDDD,5>>CDC>CCCCCCC:AA8?C@#
@8DM
GGTTGCTTTTGCTGGGGTATGGCATATATCCAAGAGAAAAGATTTCCCATAGCAGCACTCCAAAGGACCATGTGTCTTTTTTAGAAGTGAATATTCCTTCN
+
1??B?DDD>?+<:CF1@<@CGC9F@<+1?CC@FF8)9C>3B)?0?B><?F3B<9B2=.=@8;=F>3(6(..)7)7);)7?A?=;;@BA5;,((55(,;(5#
@8DN
CTTGCAGAAAAAAGGAAAAGCGCAAAAACGCCCTGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCN
+
@@?DFDFFHHHFHHIGGIGHGJIIIJIJIIJI>FHJIGIJJJDHIGGHIH?EEFFBDFFFEDACABDDDDDDDDDCCCDD09@DDDDDDDDDDDDDDDDB#
@8DO
GTTCAGAAAGCTGGCGGCGAAATCTGTGGTCCATGGGGTAGCTGCTATCTGGTATGGACTGCGATGGAGGGAGGTGAGCTGGGAAGGCCCGGTCAGGTTTN
+
@B=DDFDFHHHHHJJJJJJJJJJJJIIJJJJJJJJJJJEHHFFFFFEEEEEEACDDDDDDDDDDDDDCDDDBDD2<ABDDDDDDDDDDDDDDDDDDDCCD#
@8DP
CCATATGCCTGGGTGGTCTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGGACTGTAATCCGTGN
+
@@@DDDD8D?FFAAC:<AE>9H>A29?BFFFFBG7CFGAF1DDFF;:CCAEF<;>B>)6.;6(=5@;?888;A?3>A909A:AAAA(9088:>A>>A<8?#
@8DQ
GCAAATGAAAAAGTGTTCCTTTGCTTTTCAATCTCTTCATTTAGCTGAATACATTGTTGTTTGAGGTCCTCATTTTCCTCTATAAGTATTTCTATTTCTTN
+
CCCFFFFFHHHHHGIHHIIJIIJJJJJJJJJJJJJJJJJJJJJIIJJJJIJIIJJGIIIIIJIGGECGGIJGIJJJGIJIIEHGHHHEHFFFFFFFEDEE#
@8DR
ATTAAATGTTCCTCGTAAAATAAAGTTTCGTGATGTGCCTACTAAAAATTGATCTGCCTTTCCTTCTGCTACAGCTCTGATTGTGCCATACTGATCAGG
+
@B;DDFFFHHHGHJJJJJJJIJIIJJJJJJFHHIIEHJJJJJJJIJJIJJJFIIJJIJJJIJJIJJIIJJJJJJJCHHHHFHHHFFFFFFEEEEDEEDD
@8DS
GGCTGTGCATATCCTTGAGTGGGCTGGGCGGTGTAAGCACTGTAGCCCTGCTGCGCTGCAGCTTGGCTATAGGTACTGTAATCCGTGGACGCCATTTTCTN
+
@@<D?DDD?FDAFEHGIEH+C;@FBA@BBGG)?7B=@FB=@F)@7=;CHIIEEHDEEC8>>@CCC=C:@CC>@(;>:@;@CD@CBB@B@@B>B@B@@A@:#
@8DT
GCGATCTGACTGGCAATGTGGAGCATTTGGGAGAGCCCCAGCTCACCCTTGGCCTGGCGTGGCTGTCCATCCACAAGGATCATTGCATCTGGCCCATGGGN
+
@CCFFFFFHHHHHIJJIJHJJIJJIJJJJJJIIJHGIJJJIJIIIJJJIJJJJJJJIGGAHHFEFEEEEEEDDDDDBBBCCDCDDDDEDDCCDDDDDDDB#
@8DU
CATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGN
+
CCCFFFFFHHHHHJJJIJJJHIFJJJJJJJJJJGIJJJJJJJHIIIIJJHIIJJHGIGIIJJIJJJEGHHAEHF;@BDCCEDDDD?BDDDDDDDDDDDCD#
@8DV
CTTCCCTTCAAGGCCACATATGTCCTGTTGAGTCCAAAGCATCCAGTAAGTGTGCAGGATGGGCTTCAGCTAGAAGGCCACTGATGAGTAAGCTTCTAGTN
+
@@?DFFFFHHHHFGGIIIJJIJHIIIIJIGIIFGIIJGGEHGIJIGEGHGBBFGHJJJIIIIIJIJIJIIJIJJHEFHFFFDFEEEEECEDCDDDDDDD@#
@8DW
CCCCTTAATGTGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGG
+
=;1=B>DDHAHHHIGIHGIHH<@>HFHDFDHGHHGHGBCGGGG@GDFEEBHHIGGEIDHG<@73>@C?>CCCB?@@C:>:>A?B:AC>@CDA:A??B
@8DX
AGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGTCCATATCCTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTN
+
@@@FFDDDHHHHHIIJHHIJJJJJJJJJJJJJJIJJJJIIJJJJJIJJJJJJJJIJJIJJIJIJIHIHHHGGFFFDCDCDDDDDDDDDDDCCDDDDDDDD#
@8DY
CTGAAGTCCTATCAGCCACCAGGCAGTGCCCAGGAGGCCCAGCGCCTCCTAGAAGGCCATCCTGATGTAGAGATACCTGGTTTATAACCTTCCCAGACCCN
+
@??7?+BD4<<:::<:C;?:AA?FFDFB>?@G=F;C0D1BFDE@<:A;(8=)=)7;;(==A;);.7.>>C<CCCCCAC>9@CBCC3;>C@C>A?A@8<<?#
@8DZ
CTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCTCGTCGGGGTTGGAATTCTTCAGGGAGGGCTCCCGTGACTGGATGATGTGCACCN
+
;?+=DDAD@<AFB@F<C:F<??CF@D0:BA**??GGCHI?B8B88=B46;CBA8<3998>@A@@C>A>:@@B?@5<B@BB@<@?BC:8>C@3::@@>:43#
@8E0
GTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTATCTGGAAAGGCCATGGAGAAAAGGGCTTCTGGATCACACACAAACTTGTAGAC
+
:?+4ADBD>FHHHHIIJJJIHGICGGHHGIIJJJIGJEEGIIJIJGIIIECHJJJIFGHIIGIGGGGHCEHFFDCEEEEED?ACD?@BDDDDDDCDDED
@8E1
TGTGGTTGAAATTTCACTTTCCAGTTCCACAGAGAAGCCCTGCTCATGACTGGTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIIJIIJJJIJIJJJJJJJHJJJJHHIJJJJJJJIJJJJJJIJIJJJJJHHHHFHHDCEFFFFEEEEEEDD#
@8E2
CCCTCCTCCAGTTAATAACATCCCATTTCTCATCTGACAAAGTGTGAACACACTGCCATCATGAGCTTTGATTTGTTTGCTGATTTGATATACACCTTT
+
;?@ADDDDHHFBAE>@FCG@FHIGDHIH@HHGIIIIIIGGF@H@BFDGDCGEBBFAEGGBFHGGDHEGHGDHHG>C9;CCEEED@BDD@BCDDDCCCCC
@8E3
GCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTAATCTCTTCATGGCTTTTGGACN
+
CCCFFFDDFFHHFEHGEHIGGEFBGGGGEGIIIJJJ>FFGG)=CHIJIJIDDHHHJGHDHHHBBDACBEDDCCCDDDDCDECDDDD@;ADCBCBCD@<:>#
@8E4
ACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATN
+
@@<BAD?A?DB?F@FGIIG@GFEGIGHGEG?BBFDFIIGHGGHDCBFIIIECCCDEHHHAEHHEEECCCCCCCCCCCCCCCB:?CC>ADCA@A>CC@AA:#
@8E5
GTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTG
+
CBCFFFEFHHHHHIJJJJJIIJJJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJHHHGHFFCDDDDDDDDDDCDDDDEDDDD
@8E6
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
CCCFFFFFHHHHHIJJJJJJJJJJJGIIJHHJJBFHIHIJJJJJFGIJJJJJJJJJJIJHHHHHFFFDDEEEDDDDD@CDDDDDDDDDDDDDDCEDEEED#
@8E7
CCGGAGGGGCCGCTGCTCGGGGTCAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCN
+
@B@FDFFFHHHGHIIJJJJJJJFHIJIHIIJJJJHGFBDDDEEDDDDBDDDEDDACDDDDDDBDDDD;@BDDDDDCDDEEEDD@CDD?BDD@BDDDD:CC#
@8E8
CTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTAAGTGATG
+
BB=DFFFFHHHHHJJJJJJJJJIJJJIJJIJIJJIJJJJJEHIJJJJIJIIIJJJJJJJJIIHIIIIJIJJIJIJGJJJJJJJJJIJIHFHHHH.;CFF
@8E9
GTATAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGTGTTGTGTTCATACACTGGGTCGTGGTACTCCTGCTTAAAGCCTTGN
+
==14ABDBFHFDFGGGDEHGGHGGHJIGGGIIEEHIEIGIJI=EHHHFFFFCECAC;@A?=CCDEEDDCDD@??<A@&5>8ACCDCCACCCDCD>CDDCD#
@8EA
GCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTCTCTCAGCCGGGG
+
@@<DBDDFHHGGHIIJIJGHGGGIIIIJGJIGGHGGD?FGHIJIIGIIIBFH@FEHGEGEHGIGIGHHFFDDBDDDDDDDCDDD@CCCCCDDDDBB<9
@8EB
GCTGTTGCTGCTATTATTTTTCTTCGTCTTTTTAGGAGGAGGTTCCTTGGCTTTGCTTTTTTTATTCTCTTCCACTTCCTCTTTCCTTTTGTGCTTTTCTN
+
CCCFFFFFHGHHHJJJJJJJJIJIJIIIHIJJJJIJIJJIJJBGHHIJJJJJJJJJJJJJJJHEHFDFDFFFEEDCEEEDDDDDCDDDDDCBCDDDDDDD#
@8EC
GCTTGCACTTGTCCTCTTCCTCCGACTCATACGTGGGAGGGGGCTTGCTCTTCATGGGCGCTGGCTCCTTCTTGCTCACATTGCTGTTGCTGCTATTATTN
+
B@?DDFFFHHHHHJJJJJJJJJJJJJJJJJJJJIIJJJJJIJIJHHHDEFFFFEEEEDDDDDDDDDDDDDDDDDDDDDDDDDCCDDDDDDDDDDDEDDEE#
@8ED
CTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACC
+
@@@DDFFDHHFFHEHJJJJJHGGHGIJIJGGCHGHBFHGHEHBFHHAGGHFGII;BHF5>ACDA@CCDDDBDDD?BAACBBDCDCDDCDDDDCCD?@>C
@8EE
CCCGAGAATGCTAAACACTGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAA
+
@@@DDFFDFDHFDGEGIBHEHIJJJJIJGIGHGGGHHIIJIIJJJGJJJCIGIJIIGCGHIIJ@EGIDHEG@A?E@EHDBDDDDDDCD3>>CCCCCCCD
@8EF
CTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGG
+
CC@FFFFFHHHHHJIJJJJJJHJGIJIJIJJJJJJJJJFHIJFIJJ?FHIHJJJIJI@EEHHHHHFFFFFEDDEEDDDD:@DDDDDDDDDCCDDDDDDD
@8EG
CTGCATCTGCTGATGGTGGTGATGATGGTGCTTCTTCTGCTCCCTCCCGGGGTGCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGN
+
@@<DDDDD?DHHFGGIAEEFF@FHEGIIDHIIIIIIIIIEBCFGGIIIIIGG5;AGIHFHFEEEEDCBBACCCBBB@=?CCC@CD@ACCCBBBB<CCDCB#
@8EH
GCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
BB:DDFFFHHHHHJJJJHIJIJJJJJJJJJJHIJJJJJJJJJJJJJJJJJJJJIJJJJJJHIIJHHHHHFFFFFFEE@CEDCDDD8CBDCDDDDDD<AC
@8EI
CTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTAAGGGCAAGCCCTGTTGCTGGTAGCCGTAATTGACATTCCCACAAGGGAAGTGACGTAGCCTGN
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJIJJJJJJJJJIJIJJJIGFHHHHFFEFFFEDADDDFCDDDDDDFDDDDDDDDDDDCCCDBDDDDDDD#
@8EJ
CTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGTAATTATGGTATTTGCATCTGTTGGGTGAAACTCCAC
+
BC@DDFFFHHHHFIJFGIIIJHJJJIIJJJJHGHIJIJJIIJJIJJJIHHIJJJJIIJJJJIHIJGHHHHGHHFFFFFFFFECEEDDD?>ADDDDDDCD
@8EK
CTCTTCTCCAACAGTCATATTTTCAAAAGAAACTTTATCTTCCACCATTATTTTTGATTCTTCACCAAAACTTTTATTTACTTTAGAAACTGATCCTTC
+
;@?ADDDAFFFBDB<<CFIEDHBBHHIHAC@GFGG9ECEBFDG>DDE<:*?BGHIG;DG@DC=FGHGGGIIDHHI@7;?EHHFFH>3@D>)66;>>CCC
@8EL
CTTTGGTTTCCAACAGAGGAGAAAAGGAATTGCCTCTGCTCCCTGCCTCTTGACTGGCTTCAGGCAAGGAGGAGGCATCCTCAGTCCCCATGATAAGG
+
:?1==D++AD<CAA<:<CFI7F;CCB7BE?::?D<9:0:0?B?0*?BDDD??C<8BB=..877@9C??5AD/?;9;1555;;;:(5>A9?<?A;::4>
@8EM
GCTTCATCTCTGGACTTATAAATGCTATTTAAGAAAAAATTTCTGAATAACTGAAGTTGGTCCTGAATTCTATGAAAAGTAGGTCTTTGGTCGGGTTCTTN
+
B@@DFFFFHHHHHJJJJJJJJJJJIJJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJJJIIIJJJJJJIJIJIIJJJJHHHHHHBEFFFFEDDDDDBBDDD#
@8EN
GCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACTCTGN
+
@@BFDEDFHHHHHJJJJJJJJHHJJGIJJ:HHIIJJJJJJDGHIJIJJJJJJJJJJJJJJJJHHHFFFFFEED@CEDDDDDDDDDDDDDDFDEEEDDDDD#
@8EO
TGAAACTCCACAGCCAAAACAACTTCATTTGTTGTCTTTATTTCTGCTCCTTTTGCTTTCCTCTGCCAGTCCCATACAGTAAGCATATGCTCATTGGAGTN
+
??8?B?DD?CFFFF=FFF:FBCFGIIIIEFF?BGFFFIFIFDGIFGIIIFF@B<BBCEIIIGIAFEGCFCEDF=@EE?EF>@BBBDDABCA>AAD@>@;>#
@8EP
GTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCAT
+
C@CFFFFFHHHHHJJIGIIIJJJJJJJIJGIJFIIJJIJIIIGGIIDGHFIEGIHJJIJIJFIGFFFHFFFFEDECEDDDDDDCDDDDDDDDDDCCDDC
@8EQ
CCGGTATACAGGCCCAGGGCAGTTCTTGGGTGGGTCCATCCGGCCTCCACTGGTGACAAACTCCAGAACTTCCTGGTTGCTTTTGCTGGGGTATGGCAT
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJHIJJJJJJJIJJJJJJJJJJHHHHHFFFFFDEEEEEDDDDDDDDDDDDDDDDDDDDDDDDD<BDDDDDD
@8ER
CATGATTCAGATTCCTGGGAGCCTAGAGGACCCTCAGACTTTTCTTCACCTTGGCCACATTCTGTAGCAAGTACCATATAGTTTAACCCTTCTCGGTTCTN
+
?@1=DDDDHD>DDHGGGGGIEGDHEGGGIG?FDEDDHEGDHGGDHBDHHHGGGGHHGHIGEHCECEHHEEEECHEHHEE?DEEEEEBCCBC=AABBBB@C#
@8ES
CGAAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGN
+
:B14ADFFHHHHHJJIHIIJJIJIIJJIJJJJJIJJJJJJJJJJGIIIJJJJJJJIIIJJI;BHEBDFEEEECEBDDDDDDDDDDDDDDDDDDDDDDDDC#
@8ET
GCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGN
+
CCBFFFFFHHHHHJJIJJJJJJJJJJJJJJJIIJIJJJJJGHJJGIJJJIJJJJJJJJJJJJGGIJJJHHHFFFFD;>BBBDBDDDDDDEDDCDCCD:?B#
@8EU
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIGJJJJJJ@EFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@8EV
TTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGTATTCTGCATATACATGGTATTCTTCTCTTCTA
+
@C@FFDFFHHHHHJIJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJIIJJJJJJJJHHEHHHFFFFFFFEEEEEEECDDEEEEDDDDDDDD
@8EW
TGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
CC<DFFFFHGHFHJJIHIHEIIJIJGHIGIJIDGHGIGIGIIIJGJJJIJIJJJJJJJJJJGIHHGHHHFFFFFCEEDACDDCCDD5>@BCCDDDDD<?C#
@8EX
GGTTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCCGTGGACCTTGTGCAACTCCGAAGGAGGGTTGGACN
+
11:4==ADHFDB?AAEGBFEEHHEGEGIGGG3?F?DAGGGGGD?DF@BB;4;@CEH<7=;>3;7;BA;A@=;=CCD:CA>CCC@@?B?<BBB<BB<.5@+#
@8EY
CCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCCATGTCTGTCTTCAGCAGTGGACGCTGATTN
+
@@@D;DDAF?,<?FB?FHIICG@HHGGII<?FEBEEF;@91:BDD9BB<D>FHAHHCH>FHG@@@C1@ECHAEBEDECDC>@ACAA@?5;ACC;;8=;>C#
@8EZ
CGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGC
+
CC@FFFFFHHHHHJJJJJJJCFHGIJGHJJJJIJIJJJHIJFHIFGIJJJJJJJJJIJJIJHHHHHHFFFFDDDEDDDDDDDDDDBDEEDDDDDDDDDD
@8F0
GCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATTCTGTTN
+
?@1ADDDFHHHHHJJJJJJJJIJJGGIJIFG@HJGIIJJGIFIIIIIIGIIIJIIIGIJJJJJIJJJIEHIGIJCHHGGECB?CFEEDCEEEEDEEEEDD#
@8F1
CCAGGACTGCAACTCGGTTTTCCAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTN
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJHHHFFFFFEEEEEEEDDDDEEEDDDDDDDEEEEDD#
@8F2
CCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGACTGCCCATAGGTTGCN
+
@@@DDBDAC1C?C@BBBEAF9AE9FGCB?7<69<CACA?3>8+3@>B@C(29@AABBB?BB0:@ACC@>:AAC@CCC>CC@:<3&)989A?A3?@4+:9+#
@8F3
CTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCN
+
B@;DFFFFGHHGHJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJIJJJJJJJJJIJJHHHFFFFFFEEDD;@BBDDDDDDDDBDDDDDDDDDCCDDDD#
@8F4
TTGAGTATCACATGACTGTACATTTTCTGCCCTGTTGTGGTTAATAATGATTTCTAGCTCTCTACATCTCAATGAAACTTGTTCTTTCTCTTGCTTTAA
+
CC@FFDDFHHHHHJJIIJIJJJJJJJIJJJJJJIHIJHIJFHIIJIGJIIJJJEIIHHJIIJIIGIJIIIJIIIIIJJJIIIIHHHHHHFFFFFFFEEE
@8F5
GTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJIJJIJHHHHHFFFFFFFCDD3=BD?CDDEDDCCDDDDD#
@8F6
ATCCAGAAGAGCTACCAAAAACTGCCAGAGCTGAAGTGATCCTCGCCGTTGGTATGTGGGTCCTTCCCGATACATTCCTGGCTCTTGTTTGATGTCTCC
+
@@?BDDADFDHBCEDHGGIGGGDH@DAGGIGIIII@DDBH@HEGF:?@FFCAHGA:@>CEEHEEEDEECC>>@CDDCECCCBCACCACCCACC@B>:>>
@8F7
CCCATACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTT
+
1=<DDD;DBCCADEECE?3<CDAB+<?1:EDAE<8*0?DDEEI>DDDA9?D*84=8B8AA@>;7@CACDD3..?CAAA);.;)751;6=AA?=(,(5:5
@8F8
CATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCAGGGTATAGCTGGCATCAGTGGGCTGTCCTTAGGTTCCATAGCTTTGTTGN
+
11:=A?B+2AD>D+AEE3?CCE<D)*:)*****9*9?*///899).=CCD)6='.).)=7A;)5;;>;AAA;=(5'5--(,((5>>(,(,;,(4>>3><<#
@8F9
TCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGN
+
CCCFFDFFGFHHHJGFGIIIIICFHHI9EHEFHHHIIGG?FHGDHHG7BFH>FFHEHJ5@CEHAEDFFFFDCCCEDDDDBB@BCCCDDDC@>ACDCCDBD#
@8FA
CTGCCATCTCATAAAAGATCATCCGGTCAAAGTTGCTGGTGTGCTCCCACTCCTGCACAGCCAATGGCAGTCCCTCCTCCAGGGTCATAGTGGGCTTC
+
;?@DD?BBD?DFDGGGIBFCHICDHEEEGHCHIIIIICHF>FFHBAHEBFFDEHCHIGIIGCEGGCACHE;;@DCCCCCC3@CB?CBC@CADB?@???
@8FB
GTTGGGCTTCCATCTGTAGCCTTAAATCATTCTGTTCTGATTTAAGTACATTGAGTTCTTTCTGAAGTTTATCATTTTCACTTGGTTGAGTTGCTCTA
+
@C<DFFFDHHHHHJJJJIJJIJJJIJIHJIIJJJJIIIIIIJJIGIIIIHIJGCHIJGGIIHEHIIIIGGEHJIJJJJGFHIIJJJGHFGDEFBDDED
@8FC
GGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTN
+
CCCFFDDDDDDDDDDCCDDDDEEDDDDDDDDDDDDDDDDDDEDDDDDDCCDDDEDDDDDDDDDDDDDACDDDDDDDDD>CC@CDDDDDDDDDD<CADDDD#
@8FD
GCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGCCACTTTCCCTTGTAGACTGTTCCAAATGATCC
+
@@@DDDDDHHHAHGGE=+<CB<<FEHIICCEHGIGGIGIGHIICGIIGBGGIGGGHGHGIDFEHGIIEEHGEHG9D@;7?EEHDEBBCEEECCCC
@8FE
CGGCTGTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTN
+
CCCFFFDFHHHHHJIJIIIJJJICGHJHIJJJJJGHIJIJJJJJIJJJJJJHHHHHFFFFFFEEDEEECDDDDDEDDDDCDDDDDDDEDDDDDDDDDDDD#
@8FF
GCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATN
+
<?@;DDBBFD8A?FFFGHIHHFBEFDGG:CFIGGGFHGBBEEGIIIFGIIEG@FEGIIIDE@EHFBDDEECCACD@CC>C=??@B<BB<>CC><CCCCDD#
@8FG
GTAGGATCCAGTTTGGGGTGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCC
+
@B@FFFFFHHHHHJJJJJFHIJHHIJJJJFHJJJJJJJJJJJJJJJJJJJJJJHHHHHHFFFFFEEEEDEDDDDDDDDDDDDEDDDDDDDDDDDDBDDD
@8FH
GGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGT
+
@@=BDADDFHFHBEHH@GGIII>FBGIGB@FGEHGEEHIIICHADFGGDBBGGEECFFGHIIIGAEHGDG=EBEEB@CCCCCC:>@CBCDACCC>9:@:
@8FI
CCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCN
+
@@@DDDFFHHHHHJJJIIJJJJIJIJJJIJJJICHIJIIJJHIIJJJJJJHJJJEHJIJJJJJJJJJJIJJJJIJJJJJJJJJJGHHHHHHFEFDFDEED#
@8FJ
AGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJHHHHHHHFFFFFDFEEDDD@DDDDDDDDD#
@8FK
CCATACAGTAAGCATATGCTCATTGGAGTCATCAATAACACATAAATGAACACCTGAATCTGCTTTTGAAAAATCCAGGCATCCTACTCCACGCTCAAA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJGHIJJJIJJJJJIJJJJJJIJJIHIJIIJJJJJJJJJJJJJJJIIJJJIJHFHHFFFFFFEDCEDDDDDDD
@8FL
GGCTCCTTCTTTGCTATAGGATTATTCTTTTTGGTGGGTTTCTCTGTAAACCAGGAGCCGTACGTTGGGTTCCACAAGCTGGTGGGCTTGTTTCTGGATCN
+
@@@DDADA<C?FHBGGB?IDB:AFHHDHEBFHIHC;F@FHABDBF<BBFHEIIIDHIIIGIAHA=>?BEC1;@CCCB?55:<9???<C@@AACC@@>A>A#
@8FM
ATGAAGTGGTTTTCCTCCAAATACTGACAGCCACAGGCAATGTCCCGAGCCACGTGCAGAAGGTCCAGCATGGCCAGGGAGGAGGGCTGGCTCGGGCG
+
@C@FFFBDHFHHHGEHIIJJJJJJJGJJJHGIIIJGJJHGHGFIIIJIJJJIIGFHIGGIHEE?EEFFFFFEEECCDDD?BDDDDDDD@BBCCDBDBB
@8FN
GGATAATCTGTTTTGTAGTTCTACTACCTGTCTCTTGTAGGTTTCAAGTTGACTTCGCGCTGCGTTGGCCTTTCTTAACTCTTCCTCTAGACTGACAGT
+
?<<BBDDFDFFFFIIHEHIJJJGGGHIFGIIIFGIIIEFHE?@GDGGIGHIIIJJGEHHEBHEHGEEHGFFFFEBECECACACCCC;@CCCCA@ACDD@
@8FO
CTGGGCTCTAGCATCCTGGACACAGGACCGAGCTAGTGCCAGGCACAGGTGGGAAGAGTTTGGTAAGACACGTAGAACACAAGTCACCTAACCTGTTTCGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJ@FHIIHHHHFFFFFACEEEEEDDDDDDDDDDDDBCDEDDDDDDDDDDDDDD#
@8FP
TGCATTCTGATGACTTCTGGTGCCATCCACAAAATGGATCCAGACAACTGTTCAAACTGATGGGACCCACTCCATCGAGATTTCTCTGTAGCTAGACCA
+
;@1A?DD?ACFHFBB>FHGCHB?EHCGHGCHHDCHIGIFIEFGGB;FD?B9??DHFGGIGHCGDFGHB?ECDEEF>?DD;A@CC>>CC;@CCCECC>@C
@8FQ
GGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGN
+
?@=DDDDFHFHHHGIJJGIJIIJJIIJIJJIIIJJJJJIIIFEHCGIJJJJIIJJIFIEHJJJIJIHFHHHHFFFDEDDD=@DBDD;@CDDCCDCDCCCC#
@8FR
GTCGTGTTTTCCTGAGTACTCCTACTTCATTTTTGAAGGCTTGTAACTGCTGAGGTGTAGGTGCTGTCACATTCAACATTTTCACTGCCACATCACCATGN
+
@@<=DAD?FDHFF@FEIIIICEHIGGIIGIIIIIGEIIIIIDHIIIFHIEGGEHFIIIEGGIDCFCH@EHGHF<?AHEHFFFCF@?;>@CCBCA@@CCCC#
@8FS
TGCTGCACATCTGCTATTCTCCCAATGGGCATGGCGTGCTCTTCAGGCGGGGAGACAGAGACCATGATGTGGTTCATGTAAGCCAGGTCTTCCCGATG
+
@CCFFFFED?D?CBGHBEBIEFHHGDHA@DAF??E???DHGGHGEDDHGB>=332<?9C9?C?CC>:@ABA:+<(:>4@ACC>C32<4:@ACCCB<BB
@8FT
CCTCCTGTTTGCACATAGTTTAACACATCAAGGTTGGAATGAGCTGGATAAGGCTGATGACCAAGAGTTAAAATCTCCCAAATCAGAATTCCAAAAGACCN
+
CCCFFFFFHHHHHJJJJJGJJJJJJIJJJJJJJIJJJJJJJJJJJJJIJJJJIJJJJJIJJJJJJIJJHJJJJJHHHHHFFFFFFCEEEEEDFDDDDDDD#
@8FU
GTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTGGGGATAACTGTAGTTACN
+
@@@FFFBDHFHBFEGIIJGEHGHIIIIIJBFHG:BBFBFHIIJJFGIIJHIIECGIIIJHFFHFFDBACCCEDDDDD;@CDDCBDDDDCDCDDCDCDDCD#
@8FV
CTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCCTTCATCTTGGAGGAGCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCN
+
@@@DFFABDFF?FEHAFHGIIEHFH@D?D@FHIIEFEHEBGEGIIHGCHIGIIDHHFCCCCCCACCC>5@CA:AA@@CCCCBC?CACCCCCCCCC@C>0<#
@8FW
CAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCCTTCCATCTTTATCCACGCCAGCTATCTGTCCAGTTGCN
+
@BCFFFFFHHHGHHIFGIGEIGGIHHIHIJIJJJJJJIGJIJJJJJJGIJIGAHIIGIIJIHHHHFFFFFFEEEEEDEDBDDDDBDDDDDECDDCDDCDD#
@8FX
CTTCAATCTCATGCTGCTTCCCAGCCAACTCACTTTCCATCATCTCTAGATGAGTCGGACTGTCTTGTGCTCCTTGTTCAGAATAAGAATCATCAACACCN
+
:??:D>DB4:A4A<ECDB?FF9A+++<<22+?9*?9??*?*9C@D4@B44??B<*?((-'568)..77=).=).7=)7?@A<;?AA6>6;-;>AAA?A<8#
@8FY
GGATCACACACAAACTTGTAGACATATCTCTCTCCAGCCACCTTTTGCATAATTCCTTTCTCATAGTAATAGCGGAGTGAACGGCTAAGTTTATCATAGTN
+
@C@DFADBHDHHHBBGIIGIIHIIICCFHIGGGGGGGHBDC@GCGGIHFGIDHIFFGIIFHGIC>D=FEHGGGIGG<(;>A6?BBD?CDCDEDD>CC>::#
@8FZ
CCCCGAAGCTCCATACATCACTCTCTGTAGTGAACTTCCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCATGGTGTGTCCTCCCACCCTN
+
@@@DD@DDDFFDHIGG@DCEDEHHHIIIIIDHFDFFHDFGE@D@BFHIGCBGHHGBHIIIIGEGEHEHAED>CCC?@??=<CC9CCA8AACCACB<ABBB#
@8G0
ATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATAAGCACCAGTGCCATACCCCTGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGG
+
@@@FFFDDFFHFHI<EFAGE?CFCGGCGHGIGHGHDGIGHIIIIIIIGIIIIIIIIEIIGIIHHGEEBEFCCCECBBCC?CEECCCCBCCCCCBBCCCC
@8G1
ACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAAT
+
CCCFFFFFHHFFFGIIJIIHGHIIIIJJJIJIJFIIGIIIDIHIIJJIJJJIIIGIJGHACEHIJJIGIGGEEEEHCFFDFFDDCDBBCCDCCCBBDC
@8G2
CTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTGN
+
@C@FFDDDHHHHHJJJJJJJHHIJJIJJJJJJJJJGHIJJJJJJJJJJJJJJJJJJIJJJIIIJJCHIGGHHHHHHFFFFFFFECE@CDDBDDDDDDD9@#
@8G3
CTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGN
+
CCCFFFDDDHHFFEG?EHGGEHGIIJIIJIGIJICHIJJGCFICHHIGG@GGIJJJFIJJHF?AECBCEDEFDCCAEEDDCCCCCCDDCCCBBDDDBB9>#
@8G4
CCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJIJJFHIJJJIJJGIIJJIJJJJJJ@EHIHHHHHHFFFFFFEEDDDDDDDDEDDDCDDDEEDDDDDDCDD#
@8G5
GCCAAGTCCAATAATCTGCAGTGTGGATAGAGTAACAGAATCCCACACTCTGACGTGGGGTTGTAGAGGCTGCAAAAACACA
+
@@<DDFDDDFHHFIEGIIGIJFGEFHDCGHHIFEFHIGIIGGGGGGIIIJJJIIGBFHJJ@BHHHHEFFFDEDEEEDD@BBD
@8G6
TGCTTGACTGTCACTTGTGTTAATACACGTAGCCTTCGTTGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGN
+
CCCFFFDFHHHHHJJJJJJIIIJJJJIGHGIJJIJJJJIIJFFHGHI?DHIJFBCDEEDDDDDDDDDDDDDDDDDDBDDDDDDDDDDDDCDDEDDDDD@C#
@8G7
GTTATTTCTCCACTATGTAGAGTTCTCATTATTGTAGATTCAGGAATCACAGTTGATTCTACTCTCTGAGAACTATTTATGTACATTTCATTACACTGTGN
+
@@?DFDDEFDAHHGHDGGGGHG<IHHCCFHEGHGIIGHHIHHFHDEHGIEFHHGCHFGGEH@FDGHGIIIEGEGGHIIEHHHEAHGEIIIHHH>EEC@CD#
@8G8
TGACCTTCTAGTTTAGATACTTTATCAGAAGAATGTCTCAGCACGTCGATCTCATCTTTCAGAGACTGAGCTTCATCTGCCAAAGTGGTCAGTTCATCATN
+
CCCFFFFFHGGHHJGIIJJJJJJJJJJJJJJIIIIJJIJJJJIJJJJJIIJJIIJJJJJGJJJJJJJJIJJIJJHHHHFHHFFFFDCECEEEDFDEEEDD#
@8G9
GGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCAGTGGTGGTATCATN
+
CCCDFFDFHHFFDFGHGFHIH@HFHGCGIIIIEG:?BGHCGGG@D>DHHIGHGGIEHGHII>FHHHHHFC==>3;A>@CC@ACCACCCDCDA@B5>@CDA#
@8GA
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
@@?B=DDD;?DF?BAGGEGGHE>CHG@F@CIGGDHEFCGGIIGHIGIICGBBFGEGHIHG;7C.)=D>;)..7?BD7>AA3;39(,8?C>>???7(8C
@8GB
CTCGGAGGACGCTGGGCAGTGATTATTCTCCATGGGAGACACTGACAGAGGGTAGGACTCCTGGTGGTTGTTCTCCTGGTGCGGCCTGGGTCCCTGAGCTN
+
@@7DB@D?AA@?D?@GHBH1?F<DB?FB9:?B<D?F9DHICB=B==@FIGII17;1=CDEE;CC(6;@BB?BA5:>@CA,5>55>@BB2?C<@B3@9?@(#
@8GC
GCACCACGCGGCCCAGCTTCTCGCCGGGGAGCTTGTTGATGTCCAAGCTGAGCTGCCGCTTCTCCTCATAGGACATAGGCTTGCACTTGTCCTCTTCCTCN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJHHFFFFEEEEEEFDFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@8GD
CAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTAGTTGTCTGAGAGGTGAGAGTCACAGGAGATGTCATCACCACN
+
C@@FDDADFFDHHIGEFEDEBF?EGEBHHIIIIIIGIFE9CEGCGGGHAHIIICHGHGDHIGACCACEACHH.;B@DC@@A;@CB?BBCCDCE@CAACC<#
@8GE
CGACAATTTATTACGGCTATCATCTGAATTTTCCCAAGAATTATGTGACTTTTCAGCTGGTGATGGTCGTTTTATGCTTTTGGTGGGAGTAGCATTCTTGN
+
@@@FFFFFHHFFHFBFGIIGGGHEHHEHGGGGFGFCHIFHEGCHIHIIGHIHEGGIGHEEB==CHFHGHIFECCHC:BCFDDD(;?>?@5?CACDD>;@C#
@8GF
GCCCCTTCTTTTTTGACTTCGGAGCCATCTCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACTCACTGGAGCTCTCCGACTCTGAGGACGAGAAGCCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJIJIJJJJJJIJJJJJJHHHHHFFFFEEEEEDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDD#
@8GG
GTGCGACCGAGCTCAGGGCCCAGGCTGGTTCATGCTATTCTTGCTTTTCAGAATGGTATCCTCGTAATGACCAGCTCCAGGGGCAGTAGCGGCTTCTA
+
CCCFFFFFHHGHGJJIJIIIJJJJJJJJJJJJJIJJIJJJJJJJJJJJJJJJHHHHEEFFFFFFDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDD
@8GH
GTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGN
+
@@@DFDFDDHHFFIIIJJJJGGG<ECGGCDFG<FEGGB?GHBGEAFAHHIIEIIIEGEHIFHGHFEFFFFCEACD=BD?;@ACCDDDEDEDCDDDAACCD#
@8GI
CTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGN
+
CCCFFFFFHHHGHJJJJJJIJJIJJJIJJJJJJJJJJJDHIJIJIJJJIJJJJIHHHFHHFFFEFFDDDDDDDDDDCDCCCDDDDDDDDDDEEECDDDCD#
@8GJ
GGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGTCTTCTATAGA
+
@@;BDBDDDFDHD@FFEDFECEBHGGFGGDFIGGIECGFFIHGIIIIDGIDIGGCGHHIGGGDGGGHIGGGFGIIIGED?ACCEADFFCECECCCEDDC
@8GK
GTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGCCATATGCAGACTGAGCTGCATAGGAGGCCTGGGTGGTGGTGACTGTAGCN
+
CBCFFFFFGHHHHJJJJJJJIJJJJJJJJJJJJJJJJJJJIIIIJJJJBFHIJJJJIJIIGIIJJIHFHHEEFFFDFDDDDDDD=BD=BB9BCDDDCEDC#
@8GL
CTGGGAAGGAATCTGGAACTGAAGACCGTTTTATTAAGAGTCCGTGTCCAATGATTAGGCAGGACCTGTTTCGGAGTCTTCGCTGTCAGAGGAGCTGGACN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJHJJJJJJJIEIJFHIIHIIIIIJJJIIJIHGIIIIJHHHHHFFFFDDC@CDEDDDDDDDDDDDDDDDDDDDD#
@8GM
CATTAACTGTTTTATTTCTTCAGAAGACTGTCTTTCTTTTTGCTTAGAATTAGTCAGCTCTAATTTCATGTTTTTTATTTCTTGGTTCTTTTGCACAATCN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJIIJJJHJJJJJJJIJJJJJJJJJJJJJJHHHHHHHFFFFFEEEEDEEDDDDD#
@8GN
GCCGGCAATCACATCAACTTTCTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGN
+
CCCFFFFFHHDHFJIGGGGIIGIHDFIJIIGGGDFGGIIJJJJJGIIHIDHIJJIJAGE;ACHHFFFD>CDDDDCCCCDD?B?BDD@CDDDDDBDDCDDD#
@8GO
TGGACAGGCTGGCTGTATGCCTGGGGGGCAGTTGGAGTAGTATAACCAGTGGGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGC
+
CC@FFFFFHHHHGJJHIJJIJIJJJJJDDDDCCCDCD@CDDDEEECDDDCDDD?BDBDDDDDCEDDCCCD>CDDDDDDCCDD<BBD@CDC?CCD:CC<
@8GP
CTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCN
+
CC@FFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJAEFFEDEEEDDDDDDDDCDCCDDDDDDDDBDDDBCDDDDDCC#
@8GQ
CTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGC
+
CCCFFDDDHHDHAGEGHIEHEHGGHIGEGG?FGGEGIJJGIIGGCHGGGIIE??F@FGICGCE@@EGFGHHHFFFD7;CBCC@B=C?BCCCDCBB2?C
@8GR
GTCGTGATAGGTGACCTGGAGCGGTGCAACAGTTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGGGGTCCTCTGGACACAGTTATN
+
CCCFFFFFHHGHHJJJJJIJJJJJHIJJJJJJIJIHIIJJGGGJFGIIGHIJJI?EHHHHFFFFFFFEDDDDDDDDDDDDDDDDDDCDDDCDDADDDDDE#
@8GS
ATAATCATCTTTGGCTGCTTCTAGTCTGAATGTTTCTTCTTGGAGCTGTTCTAATTGAGTCTGGAGCTGCAAATGCCTTCTTCCTGCTGGACTGTTAGGGN
+
@@@DDDDDFFFFBGIG1EGI<FH@H@EH@BH@+ABCGF<FECH>;;F>HGEFCGHI4?<D<DB88=CFA@F>CF)47C@@?ACCE=>BDD@;>?ACCCC?#
@8GT
TCTTAAGGTGTCTCAGGTTCTCCGGGAAGCTCCCCTTCAGTGGCGGTGAATCCCTCATTGGGGGAACCATCTTGAACCGGTGCGGCCCCTTTCCCCCCTTN
+
@@@DDBDDCDFDBGB@BFIGIEHB:F@GCGCD???FDFDBFG?D@A-5-))))7).()))7=988'(,((54:(4+(()&&&&&&&&0&(((((+())&(#
@8GU
GGCTGCTGCCCATAGCTGCTTTGTTGACCATAGCTACTCTGCTGTCCATAGCTGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATN
+
B@CFFFFFHGHHHJJJJJJIJJJJJJGIJGJIIIJIJJJGIJJIIJIEIHJJIHJAHGIIIJIJJJIJHHEHHEFFFFFEEDEECCDDEDDCCDDCDDED#
@8GV
CCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATCCTTGAGTGGGCTGGGCGGTN
+
?@@DDFEFFHHHHJJJGIIIJEHGIJJJJJJJJIJJGHHIJJFGGIHIEGHHIJJJIJJIGIJIJJ8@GHHFHEHFFFFFFFEEDACCDDDDDDB@BBB9#
@8GW
CTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCN
+
BC@FFFFFHHHHHIJJJJIJJJJJJJJJJJIJJIJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFF9>B?CDDDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@8GX
CATTGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGAAGAGTAGGATATTN
+
@@+?DDEDHFHHGIIGGGCHGIIIJHIJJJJIIJJIJIGIGIGIIIEHIJJIIIIJIGIIIIJJJIIIHHHEEDFFFED>ACCDDDDCCDB:ACCDDCCD#
@8GY
CTCAGCTTGAGGTTTCCTTTTCTTCCGCAAACAGGAGGTGACATAGCGCTCCAGCTCACGCAGTGTGGACGGCTTCAGGGTCTCAAAGTCGATTTCAATCN
+
@C@FFFFFHHHHFHIIJJJJJIJJJJJJJJJJJJI@GH8?DHIJIGJGGHHI=FHEHGJHCHFBDFCDDEDDDBDCCDDDCDCCDDDCAC@BDDDDEDE@#
@8GZ
CAGGCATTTCACATATTCTTTCTTCTTTCTGCGACATTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCN
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJIIJJJJHHHHHHHFFFFFFFEEEDDDDBDDDDDDDD#
@8H0
CTAGGCTGGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGN
+
BC<DDFFFHHHHHJIIIHIJJJJJJJJJJIJJJIIJJJJJHHIJJJIHIJIJJJJJJJJJJJHHHHHHHFFFFFDDBDBDDDDDD@CCDDCDDDDDBDDD#
@8H1
CCGGTCGGAAGAAGGTAAACATTAGCTCTACAGTCCTTTCCTCGATAACCATATGCCCACTCCAGTTTGAGCTTCTCAGGAGGCAGTTCCGTTCTGATGTN
+
@CCFDDDDAHFFFHGCGFHIGGGIGIJIIJCHJIBHHGJDEFCGFHGICFFGGI;FHHDA6D>?==?C@@BDDC>@>@CCA?;BBB?A>@@:CCBDEDCE#
@8H2
CTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCAGTGACTGGCTGCATGGGGTAGCTCCCAGGTACCTN
+
CC@FFDDFBFABFHIGGBHIGIBBGI?E?GGGGGDHBGD?BDGDFHGIDHIF;@E>FHC>DC5?EEC@BDBBC?ACBDACC@BD3=<:;A><?CB4@CCC#
@8H3
GGGCCACTCATGCTCCGGTTCTCTCCTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTN
+
@@<DDFFFHHHHHGHIJIFHIJIIIGIJIJJJJIJJJJJJJJJJJIJJIJJJJJJJIGEEHHHHFFFEEEEEEDDDDD;?B>DDDDCDBDDDDDDDDDDD#
@8H4
TGGGCTTTCCTGTTCTCATCACAAAACTGCAACCATTTACCTCTGAACTGCAGTCACCGATGTATCTCGTATGCCGTCTTCTGGTTGAAAAAAACCAACCN
+
=?1BD?D;CBDB:AC,<CEFE>FF3EBCH<?AFE)CBFG@FF>B9B???FFE9BDFBFD<4A()@.=@D-5.=)=9,,;=>6;(55;5,5,,'&&(++(5#
@8H5
GGAGGCTGTCCATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATN
+
?@=DDDFFBHHDHGHIIIGHHEHIJG4AFF?GHGBGCFHIG</./.B=@@CH==;;CCEEH6=B;@.;@AC36@C@3@>5(5(15=9>C>CA3>ACA@C:#
@8H6
TGTAGGGGTGGGGGTTGCAGCAGCCCCCTTCCGGCATGTAGGCCATGCTCTCATCAAAGTGAGAAAGAGGCACTGTGTCCTCCTCGTTGATGTGACGTTCN
+
CC@FFFFFCFDFHD@DFBHIJGHHHGBHIGIJA<BFFDDEECDCDDCCCCDD>CCDDDC>A>CCDDDDDBBBD?CCCDCC@CCCCDABDBCA4:>@B@DD#
@8H7
TGCACAAATTTTGGCTTTTCATATTTCCCAAAAATTCCCTGTTTTCTTGTTAGTGAATTGCCGCTCCAGGTCCAGAAGAAAATATGAGATTTACCGCATGN
+
@C@DFFFFHHGHDIJGICH@HGIEIJFHIGIJIIIIIIEGHDBDGHIFEHGIJJIJJJIGIHBB8AGGHCCAEHFEFFFECEECEEEDDDDDDEDBBDDB#
@8H8
GTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCCCATAGGCTGGATAAGCAGGCTGAGTGN
+
CCCFFFFFGHHHHIJJJJJJJJIHIJJIIIJJGIIIIJJIJIJIJJIJJJJGGHIJDHIJEIIIHJIGFEEDFFFCCCEEEDDDDCDDDCDDDB@AAA@C#
@8H9
CCTTACATCTCATCCAGCTCTGCCCGGAGTTGTTCTAACTTTCTTTGTGTTTCTTGTTCCATTCGTTGTACTATATCAGTTTCGAACTGGCTGTCTTTATN
+
:;1=AB;DDFAFFEGGDACGEICHCE<EE11CDG@FFDHFHGFGCHIGEHGG@HGAFDCE:@AGHGGGCD>EEEFHE73?C>75?A>=C?@?B=:>@;A@#
@8HA
CAGGAGAAGGCCGGTGATTTGTCGTGATAGGTGACCTGGAGCTGTGCAACAGCTCAATGGTGGGAGGGTTATGGTGCACATTATCCACGGATGGCCTGGTN
+
8=?ADB;BB?::@EFD+AFAHD?C?C3;DEF*0::090))?B(9/8)8)=(8(8=)7=:)77;?;?83?(=3>5(5(,,:3>@35((+(&&))((3(2((#
@8HB
CGCTCGGTTGCCCATAGGTGTTCTGCTGAGAGTAACTGCTCTGATCATAACTAGTCGGCTGTGTAGAGGAATAGCTGGTAGGAGGGTAGGATGGAGGTGCN
+
CCCFFFFFHHHHHJJJJJHIJJJJJJJJIJIJGHIJJJJJJIJJJJJJJJJJJJIJJJJJJHHHHHHHFFFFEEEEEEACDDCDDD5?BDDDDDDDD<BD#
@8HC
CCTCCTCCAGGGTCATAGTGGGCTTCAGCCGGGCCAGGGAACGAAGCACTGGGATAAGAAAACAGGAAAGAGCTTCTGTGTCAGGACTCTGGGATAGGTGN
+
:?:BA=22A<3@2C:??:A<?3FG@3<F*):))0)0?B((.<@';FE37=?>((=7@B;?@@CCC9;(5;5,9:(,5>>AA3@@@>@(+:A:<8((+(+4#
@8HD
CTGAGAGGCCGTCGTCATAAATCAGGGAGTCAGATGGAGTGGACGCCGCAAGGTCCAAGTAGTCTCTCCTCTTAACCATCATCTTCTCCAGGTCTTTGCTN
+
@@CFFFFFHHHHHIDHIHIJJIIJGIIIGDBGIGBFHIJBGGDHGHHE<EE<?;@ACEC;>>5>CCCCCCC@CDDDDCCCDDDCDACCDD:?+::CACAC#
@8HE
ATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAGGTTCCATAGCTTTGTTGCCCATATGCCTGGGTGGTCTGTGCATATN
+
CC@FF?DDFFAHHIHIJJJFGGIHJIFHGIGIGIGIIJJJIJJIJJJJHIIIJIIIFIIJJIJJJIJIHIIJGIHHHFFFFFFFFD@CD@CDDDDCDCDC#
@8HF
GTGAATTTTTGGCAATGAGCGGGCCAGCAGCTCAATAGAGGCGAGAATTTGGGGAAAGAGTGGTCTCTCATCTCTTTTCTTTTTGAGGCACTCTGCCATTN
+
=@?D=D:AADFA>A:FG@3:@EG@DDD6?D?@B?F<8.B4=C;:'99;>ACA<3;;@<>9A><,5>AB>4>A>(44A@34:A>45<?3(++9+4(+++4>#
@8HG
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
@@<DDFFDHHFFHGIIIIGIBFHIIIII1CBFFHIIBFGIHIEGIIIIIIIGG;DHFHEEFFEAECEECCCCCCCBCCCCEEFECCCCCC@CC@CCCCCB#
@8HH
CTGGTCCGGAAAATCCTCCAGACTCCTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGN
+
BCCFDFFFGHHHHJJJJJJJJJJJJJIIIJIJJJJJJJJJJIJJJJJJIJIJJ@EEBEFFFFEDDDDDDDDDCDDDDDDDDDDBDDDDDCDDDDDCCDCD#
@8HI
GGGCTGGTTGTAACCCCCTGTGCTAGATTGAGGTTGACTAGTCTCAGTGGGCTTGTTTCCATCCTGCGGTCTTGTAGGTGCAGTGGCTGCTGGCTGCTGCN
+
@C@?DDDDFDHHHIIIGIIIGIIIDHHIIDIIICFFHIIIGHIGGAHHGIIIIIIIIIIIIIIGIIGHFBCCECCDDDACDDDCDDDBBDDDDDCDDBCC#
@8HJ
CGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGTAGGATCCAGTTTGGGGGGGGTAACTAGTGGGAGGCTGCTGCCCATAGCTGCN
+
@@?DDFDA?=DDFHGEGEHGBEFEAHGIEEHIICHEHD@;BFGGGGGCG@B>?FHGHIHHGA;@@'05;05AC>CCCCABA?B??A<CC:A?C?A>A:@9#
@8HK
GGCATTTCACATATTCTTTCTTCTTTCTGCGACACTCTCGAGCAGCTTCTCTGTTTTTCATTAACCTTATTTCTCTTTTCAATTGGGGGTCATCTGTCTTN
+
?;+BD;D:A:=?DBE>:<<F@:<?A:<F441<C11*1*10*0@)??????=8)/>8.5@E>C7))7@@=ADC:7);A;7.)).66>@82=8(44>3+(++#
@8HL
CCAGTCATCAATTCATACAGAACAATTCCAAATGCATATACATCTGACTGAAAGCTGTATGGATTTTTATCTTGCATTCTGATGACTTCTGGTGCCATCCN
+
B@CFDFFFHHHHHJJJIJJHIJJJJJJJJJJJIJJJIIHIJJIIIJJJJJJJJIJJJGHIJJJJJJJJJJIJJJIIIJIJIIJJHHHHHHHFEEDFEEDE#
@8HM
CTTGTTCCTTTCTGGATTCAGATGCAGAAACAATCTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCN
+
=?84ABDDFDDDFA<A:AC:<:<<?BEB:AADFGIIIDGIIFCFDFE?DFBGDFBF@GDFIEGIIF@BD@CF=..)7CEEEFFE77=A?BBDDD>BA>AA#
@8HN
ATAAGAAGTTGCATAGGCGGTCTGCCCATAGGTTGCAGTGGTCTGAGCCTGGGTATAGCTGACATCAGTGGGCTGTCCATAG
+
CCCFFFFFHHHHHJJJIJJJIGIJIJJFGGGIDHHGIIDHHHIIJIJJJJJJJ@EHIJJHHHHHHFFFBCFDDDDDDDDDDD
@8HO
CTGCCCATAAACACCCATGCTACTGGGGTGGTCCTGTCGGAATGAACTCTGCTGCCCGTAGCTGCTGCTCTGTTGGCTATATTGACTTGGAGCTTGGCTGN
+
B@+DDFFFHHGGHGJJJJJJJJJJJIGIGGIHIIJGIJIJHJIJJJJGGIIIGIIGHHEFDFCEEECECCCCDDD@ACDDEEEECCCDDDCCCDDDDCDB#
@8HP
CTCTGGGTTCCTGTTTAATCATCAGAGGAGGGGGAAAGCTTTGGCTGGCCGCACTGCCAACCATGGGGTTGTGTTCATACACTGGGTCGTGGTACTCCTGN
+
???DD>:2A:?D4:C::EB>EEF4F3CF3?E1))(0/8B8BB8=375';C=<?@<A6(>;(',55:((,8-50<9(:::4((+4<<>?>&55(++:>A>A#
@8HQ
AAAAAGAATCCGAGGTTTCCTCTGCTTCAGAATATGCTGAAGGAGTTCATAGAGCACATCACCTGAATGAGGAGATCGATAGCGAAAGTCCTCTTTGGTCN
+
@@7DD:DDAHDFDHG@FGHGIECBHGHDEDEHBFFDFGHIHFGHGBB?FEDFGIIGBCDD@FHIIGEHEF>;>B;BCCC@C>CBBBB=5>CCCCCCC9?C#
@8HR
CTCAAATTTGGTCTCAATGATATGGAGATGGTGATACAAGCTGGAGCCCTCACACCACTGGGTAACAATAGCCAGTTGTGGCTTTGTGGAATAGCCCATGN
+
BC@DFFFFHFHHHJHIGIJHHHIJJIGHIJIIIJJIJJJIJJJIHBGGIIHGGGIJIJIJJIGIHGEGGHEIGEHEHFDFFDEEECACBDDCDCCCDDDD#
@8HS
CTCAGCTTTCAAATCTTCCACTGTACTAAGGGACTTATGTGCTTCATTAAGTTTACTTTCTTGTTCAGCTATGGTCTGTCTAGCTCTCTGAATCTGTTCCN
+
@<:ADA?AFHFHD<?GBDIEII@HD:FC?FHIICD@91C:DDED???BFB9::?@GHI@GHBFHEDBG8=FH@=8>77@@@DHA@?EHCA;?7.7;;CCF#
@8HT
TTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGT
+
CCCFFFFFHHHHHJJIJJGIIIGGHJIJJGIIJJAGGGIJGHIIGE;FCHIJIHHHFHHFB@?A>@CCCD;(;A;>ACDDDC?B>><-<>CCC:>@>:@##
@8HU
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTT
+
CCCFFFFFHHHHHJJJJIJJIJJJJJJJJJJHIGHIJJJJIJJJHIJJJIJGHHHHHFFFFFFCEEDDACDDDDCCDDCDCDEDDDDDBDB##########
@8HV
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTT
+
CCCFFFFFHHHHHJJJJJIIIIIIJJEGGIJBIHIJJJJJJIJIGIIJIIIJHFHHHFFFFFFECEDDACCCCCACCDDDDCEDDDBDDDD##########
@8HW
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGCGTCACTC
+
CCCFFFFFFHHH>GIJIEHGIJIIJIIJEGIJJEBGGHIIIHIJJIIHHIJHHEEFDFDDFDEEEDDCBDDCDDDDCCABACCCAA@CBBBD9&00&9BCC
@8HX
CAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGAC
+
CCCFFDDFHGHHHBDHJHIJJJIJJJJHGHIIIIJHIGCC1BFDGFHJFIJGEEDF>;@CA.;@C@CBDDDBDDDDDDDDBBD?CC@CDDDBDDDDDCDD@
@8HY
GTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTCCAGGACAGAGTCCCAGCACAAAGCGGAGACTC
+
@BCFFFFFHHGHHHHIIIIJBHIIGIGGHIEGGHIBGHIEIIGJIJIJJHHHHHHFFFFDEEEEDDDC;?@CD@BCDDD@CDCDCDCDDD?ACBDDB@BDD
@8HZ
CGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCA
+
CCCFFFFFHHDHH@FFHGIIDGEHIGHDEH@FHBHFB:FEEBH<=DGHHDB?CCEEBDDDDDC?CCCCB<ABCAC@CCC<><CCDD<CCDC:@:CB9?CC>
@8I0
CCCTGGACCGTGTGCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAG
+
@@@FFFDEGHAHH3CGGBIHGFHEHHBGH;DHIGFDGGHHAGCHCDEG>GDHGFFDDCEED@CBBD<<C(:AC<<?CCDDCDBA389?4>CDC@?CDDDBA
@8I1
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTG
+
CCCFFFFFHHHHHJJJJIIJJJJJJJJJJIJJJJJJFHIGIIJJJJJJJJIHHHFFFFFEEEDDDDDDDBDDDDDDDDDDDDDDDD>CCCDDDDDDBDDDC
@8I2
CGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGA
+
C@CFFFFFHHHGHJJEIJJJJJIIJJGGIIJGIJJGHHHIIGIIGIJJGJIEECACDFEFFD?=CD@BBDDDDDDBDDDDDCCDD>CCDDDDBD><>BCC@
@8I3
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGGCTTCTAGGGTCT
+
@@@DDDDDFFFFFFI)C)?FFF<D@FG<<DDF@FFBB?@0ACDFF;.@A4?<?;?@AB>=88?3;?>A@@@22<B@3>>>43:94:8?&05?#########
@8I4
CTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCGGAGACTCCGCAC
+
CCCFFFFDGHHHHJGIJJJIJJJJJIJJIJDHIJGIJJIJJJJIJJIJJHGHFFFFFFEEDEEDDDDDDDDDDDAACDCDDDDDDDDDDDDDBDDDDDDBB
@8I5
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJJJJJJJJJHHHFFFFFEEEDBDDDDDDDDDDDDDDDDDDDDDDACDDDDDDBDDDDD#
@8I6
GGTCCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCGGA
+
@@1ADDDDHHHHHJJJJHIGIIIHJBGHIDI@FCGIIGHGBDCECFEEGIHHFFFFFEEDCECDDDDCDDDDDCCACABDDDDD>@CCDCBDDDD<?CB>B
@8I7
CGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTC
+
CCCFFFFFHHHHHJIJJJJJIFHIJJJJDHIJJJIGIJIJJJJJJJIJJIIGHHFFFEDDBBDDBDDDDDDDDDDDCDDDBBBDDDDDDDDDDCAAC?@<>
@8I8
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
@@;DDDFFHHGHHIIIIIIIIGFEA?@DB1DAFGEB:FG>CAGGGIIFIGHEE=BFFDBDDDDBDBCCCDDCDBB@CCDD>A??BDCC@CDDDCCCDDB@#
@8I9
GTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAG
+
CCCFFFFFHHHHHJJIIIIGGGHJIJJJDHAHIGIIIJJI@;5@EGHIGDHEFCDEFBDDDDDDCCDDDDDDDDD@CC?CDDDC<@CDBBBDDDC3:A@CC
@8IA
CCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCT
+
@@@DDADDF?DDFHHHECDB@?)?FDFECH;DD@B0@CD=DGBBBE?CBCDDCDC;@AA@B?82</<@&0535234::<B39<CCC@:A32<<BACCA@::
@8IB
CCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTC
+
CCCFFFFFHHHHHJJJJIHJJJIIIGJJJJJEFHGFGAE;CHHHHFBBCCEEECDDECCCDDDDBBDB??@BBDDD?@CCBB@D@ACCDCC@BBDBCAC@C
@8IC
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTG
+
BCBFFFFFHHHHHJJJJIJJJJJJJJJJIJIIIIIJ?FHIJJJJJJIIGIGH<EDFEFFEEDCAD?BB?BB@DDDDDDDDDCCDDD@CCDDDDDDDDDDDD
@8ID
CGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGC
+
CCCFFFFFHHHHHJJJJJJJHIIJJJJIJJHIJJJJJJJJJJIJEHEEF<A5>ACCDDB:?AADCDCEECCAA5>8?BBB?BDD@<B8>AC@BB9>@CD?:
@8IE
CGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGC
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJIJJJJIIIJJJJJJJJJJHHFFCDDDCDDDDDDDDDEEEDEEDDDDDDDDDDDDDDBD@D@DDDDDDCDDCDDC
@8IF
CGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGC
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJIJIJJJJJJJJJJJJJJHHGDFAD?CCCDDDBDDCCCDEDEEDDDCBBBBBD9<?<@D<B8ACCD@@BBDDDC>
@8IG
CGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGN
+
CCCFFFFFGFHHHIJFIJJJJJIJJJGIIJIJJJIIIGHHGHIIJJIJJGIEEHHHFFFFFCCCDBBDDDDDDBD>BDDBDDDCDCDDDCCDDDDDDDCD#
@8IH
GCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGC
+
CC@DDFFFHHHHHJIJJJJIJIIIIJJJIIJJJIJJJHGGIIIGFFDEEEEEDDDDDDDDDDBDDDDDD?CCDDDDDDDDDEEEDEECDDD>BDDDD@A?9
@8II
GCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTC
+
CCCFFFFFHGHGHJJJGJJJJJJJJJJJJJJJJIIJJIJHHHHFFFDDDDDDDDDDDDDEDDDDDDDDDDDDA7909092?CCDDB<BD>CCEDCDD:A@3
@8IJ
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAA
+
@C@DDFDFHFHDFJIGCHIHGIEGG:EGECDFHHIIIDHCGGFBFCFFCGIGGIJJGHHFDFFCBDBDDDAACDDDCCCCDBDDBD9>>CDDDDDBCCC::
@8IK
CTGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTC
+
CCCFFFFFHFHHHIIIIEGDEHGCH?FHG1@FHIHGIHGABF)=FDFGAB?9<=ACCD?BBBD@BD?BBB59@DBC@>A@?3<59<<<@9<<<>@######
@8IL
GGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCA
+
CCCFFFFFHHHGHJIGIHIJJJJJJJHICHHHIJIJJJIJJJJJJJJJJHHHHHHFFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDD@DDDDDCDDDDDDD
@8IM
GGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCA
+
CCCFFFFFHHHHHJJJJIJJJJJJJJIJHIIHIJJIJIJD0@FFIGGGJ=AEHCHF<BCDDDDDCCDDDDDDDDDDDDDDDDCCCDDDDCBDCACDDCDDC
@8IN
CGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGG
+
CCCFFFFFHHHHHJJJJJJJJJJJIJJIIJJIJJJJJJJJJJHEHHHHHFFFDDDDDDDDDDDDDDDCDDDDDDDBDDDDDDDDDDBDDBBDDDDDDDDDD
@8IO
CCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGA
+
CCCFFFFFHHHHHJJJIJJJJJJJJJFHIIJJJJJJJJJJJIHGHIIJJJJJJJJJHHHFFFFEDDDDDDDDDDDACCCDDDDDDDDBDDD>CCDDDDDDC
@8IP
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCT
+
@@@FFDFFHHHHHJGGGIJFEHIIIGGIEIJJJIG?GGIHIJFIGIHJIIJFHIIIFGFFDDDBDDCDD:@CCCC@?BDDDDDDCDDDDDDDDDDDDDDDD
@8IQ
GCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTG
+
@@CDFFFFHHDFFIHGEHIJGGIIIIEEIHIAHFFCD?BDDDDDDBDDDDDDDDBDDBDD@BBD??BCDDDB9;?>CC?CC<@@>BD@CCC@CCCDD9<A9
@8IR
GACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCGGAG
+
CC@FFFFFHHHHHJJJHIJJJJJJJJJJJJJJIGJJGGI=FGHIJJIJJHHHHFFFFFDDEEEDDDDCCDCCCDDDDBBDDCC>CDDDCDDDDDDDCDDBB
@8IS
CTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAG
+
@@CFFDDBFHFDHHGEIEGGGIGIFJ7AFGIJIGGHFEFDDBDDDDDDDBDDDDBBDDDDDDDDDDBDDDDCDCCBBB5<@DDDDDCBBB>DBBDDDDDCC
@8IT
CTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAG
+
@@@DDDDDHFFHFGIIIGG@AFGA))?@7@FGGIBCB<DCCBBBB=BBBBBBBB<AC@BB(5AAB0<ABBC9AC>A<B55<@CCCCCB@&)59??<C####
@8IU
AGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACA
+
CCCFFFFFHHHHHHGHHIIGIJJJGGIJJGHJEHJEGHIIIIGIIGIBGHIFHEHDFDADCCDCDDDDCC<ACCCCCD<?CC@>??BDB9A>ACC@ABDDC
@8IV
CCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGC
+
CCCFFFFFHHHHHJJJJJJJIJJJJJIJJJJJJJGIIGIJGGGFHIGGIJJGHFFDDEDEEDDDDDDDDDDDDDDCCDDDDDDDDDD>CDDCDDDDDDDDC
@8IW
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAA
+
CCCFFFFFHHHHHIJJJGHIIIIJJGHIGIJIJJJJJJJJJHJJJJIJJICHHJJIHHHFFFFD8>BDDACCDDDCACDCDDBDDDB>CACDCDBD?CCDC
@8IX
GCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGN
+
CCCFFFFFFHHGHJHJJJJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJFIHHHFFFFEAEEEDEDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDD#
@8IY
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAA
+
CCCFFFFFHHHHHJIJIIIJGIJJJIIIGIJEHIIICGIIIGGHIJJIJIJIEHGIGEE@DFFDABB?C<CCCCBC>>CCDDD<@BDBDCC>>@?B<?9@>
@8IZ
GAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCAC
+
CCCFFFFFHHHHHIIIIIJJJJJJIIJJJJIJJJJJJGIIIJIJJJJJD=DHHHHFFDDDDDDDDDDDDDDDDDDCDDDDDDDDDDBDDDCD@CCDDDDDD
@8J0
GTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCGGAGACTCCG
+
CCCFFFFFHHHHHHIGHJJIJJJJ:FFBHIGGH*?DDDGHGIJJJJJIIHHHHHFEFF@CEE@ACCCDDDDDBDDDDAC(:@CBCBD88??>55>B@CCDB
@8J1
CAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGG
+
@@@DFFBDD=FFHIGGGBHHHGHGCCF>FHCHHGGGGGHII??BFGIDGBAAADACCBDDB@?<55>BB<BBBB?B@BBDBC9<B?BBDDB08AACD@?9<
@8J2
TGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAG
+
@CBFFFFFHHHHGJJJJJJJFHHHIIIJJJJJFGIJJJHIJJJIHIIJJJJJJJJHJJJJJJJHDBDDDDDDDDDDBDDDBDDDDCDDBBDDBBDDDDD?B
@8J3
GCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGCCTTCGCC
+
CCCFFFFFHHHHHJGHJJJJJJ?ECGHIIJJGIICHIIJJFHHIJJHHIJIJJJJJJHIIJJJJJGD8?BDDDDDDDDDDDDDDDDDDDB2<B########
@8J4
GGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGC
+
CCCFFEDFHHGHGJIHGEEHGHGAFHHHHHIIFHI:?FEHI?FFEGG<FIIBGHEGIJHGGGHJIHHD:@<?9AB@??BDDB>B@(8<?<BBBBBBBDDDD
@8J5
CTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAG
+
B@CFFFFFHHHHHJFIJJIIIIIJIIJJJJJJJJJJJJIJIIJEGGIJIIJJIJHFFFEEEEEDACCDDDDBBDBBBDD@CCD8?CDD:ACC?CB??C@CC
@8J6
CCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACC
+
CCCFFFFFHHHHAGHGHIJHIJJJJJJJHIIIIIJIJJDHGIIIIJ=CDHHIHFFHHHBDFDFEACEEDCCACDDDDDDDDCDDDDDDDBD<@?CDDDDDD
@8J7
GGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGC
+
CCCFFFFFHHHGHJJIIJJCFHGHIIGIIIJIGBGHIGGGJJIIJIJJJIJJH>A=BBBFFDEEDEECCCD=ACCCDCCCDCCACCDDCABDDDDDBD09?
@8J8
CCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCGGAGACTCCGCA
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJJIIIBHHIIJJJGIJGIIGIJIHHHHFDFFFEEECEDDDDDDDDDDDDCCDDDDDDDCDDDDBBDBDBDDDDDD
@8J9
CCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCCCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTC
+
CC@FFFFFHDDHHIIIGIJGGIIGFGHGIGGIIIJIJGEFHJJJJIEBFGIGGGJIJIHEFDBACCDCEBCDDDB<?<CBB:84<8<CDDCDBCCCC@A<?
@8JA
CTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAG
+
@@CDDFFFGHHHFGHIIIJJJJJJJJGIJICFBGDGGFBFG7BB;C(<FHGGAHEBFDBEDE9?;@CDCCB@DDBB@CCC@CCDDCCCCDCCD9<C?<CD@
@8JB
TGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAG
+
CCCFFFFFHHHGHJJJIJIJJJJJJJIJJJIJJJJJJJJIDIJJIJJFIJHJJJIJJJJJJIIJIHGGHHFFFDC=ABDDBDDDBDDDBDDDC>CDCCD@@
@8JC
TGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAG
+
@B@FFFFFHHHHHJIJJIJIJJJIJJJJJJJJJJJJJJIGJGIIJGIJJJHIJIDGGIEEGIGEIHHHHHEFF?AA>@BBDADBDDDDDDDDCDDDDDD>?
@8JD
GACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCCCAAA
+
@CCFFDFDHHHHHHGIEGHHEDFE1CEFGGIJIFEHGGHGIIIB;/)=DHCEBH<B>CEEDDCD?BCDDD55?CA<?ACCC:<?BC?CC>>A>CDD(8<A1
@8JE
GTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTT
+
CCCFFFFFHHHGHJJJJJJJGJGEGEHIJJIIJGIJCHGIIIHI@GIJJHIJEHGJIICECHFFFFFDE@CCDC@?CBBBDBDCDDDDD@BB@C@9BBB88
@8JF
CTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJIJGFGHIIIIHIEGGIJJJGHIGJIJJJGIHHHHFFFDDEEDDDDDDDDDCDD:ACDDD@B<BBDDC>CCDCDB?
@8JG
CTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACATCAAATTCCAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTT
+
CCCFFFFFHHHHHJJJJJFHJJJJ@FHIJJJJJJJJJIHIJJJJHHHFFFFFEEEEEEEDDDD3;CCDEDDDDDDDDDDDDDDDDDBBDDDDDDDDDDDD@
@8JH
CTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACAT
+
CCCFFFEFGGFHHIIJIJGIJJJIJJJGIIGJIGHIJEGIIIIGGIJIJIJJIGACEHFFFFBDADDBD?@BDDDACA#######################
@8JI
CGGGGCCTTTTGCTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJIJIJHHFFFEEEEEECDCCDDDDDDDDDDDDD5@BCCCCCDDDDDDCCBBDD
@8JJ
CTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCCAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCG
+
CCCFFFFFHHHHHJJJJJJJJGIIIGIGIJJGIGGJGIJJII@FIGIIJDEHFFFDEDECABD=@BDDCDCDDDDCDDCB@BCBCD>CCACDDDBDDB9?5
@8JK
TGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCC
+
@@@DDFDFHHGHGIGIIHGHEEHIJJCHIIJJFCFHHIIIGGE<FHJCEHFHHFEFBDF?C>BDDDD@5:ACDBCCC:>>C?<8<C34:48????CC:@@:
@8JL
CTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCCTTTTGCTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCC
+
CCCFFFFFHHHHHJJIJIJJGJJGJJJJJJJJIIJJJJJIJFDDBDDDDDDDDDCDDDDDCCDDDDDCDDCCDCD?DDDDDDDBCC?BD>>B<ADDDDDDD
@8JM
GAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCCTTTTGCTGCCTCACTGCTGCTTTCCTCAAG
+
CCCFFFFFHHHHHJJJJJDD8BDDDDDDDDDDDDDDDDDDDDDDBDDDDDDDDDDDDDDDDDDDDDBDDDBDDDDDDDCDDDDDDDDDDDDDDDDDDDC@C
@8JN
CCCCAGTCGAGGTGGTAAGAGCCCCGAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCCTTTTG
+
@@@F?DDDHBHGFHGFHIJJIJJIGJGHEHGIBGIIGIIJIJJDD7<BDDDDDDDDDDDDBDDDDDDBB?BBDBB?CCCCDCDD?BDDDDB<>BBBD@CA3
@8JO
GTTTGGGTCATCCATTTTGTCCCAGTCGAGGTGGTAAGAGCCCCGAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCA
+
==1=DDDAFHHHHIGIJJGIGHGGHHGHFGI:DG@GHIIIGIIIGFGIGIEGIJJFHHHFFDDD@@AAC@CCDCC>C@BDDDBCDCA@?BDBB22@CCCC3
@8JP
GCCGCTGGCTGGCCCAGCCTGGTCTCAGGGCTTTCTGGGGGCTGGGCCTCACTGCCACCAGACTTGGTGTCACCTCCGAACGGGATGAAGTCTGGGTCATC
+
@@@DDDD:DFAAFGII3AAEFCEFCGF<1CBFEEF@FFEFAFDF:@=?EFFDDD>7@>A6(5,(;A3:??BBBBBBB@BB@@<B@BBA:@###########
@8JQ
CTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGGCCTCCACCAGCTGCTTGAAGGGGGGGCTCTGGGCGGGCGC
+
CCCFFFFFGHHH?D@BHG@CBGCC@=@8@;A4?BA>?<A7ABB(;?:>39?98;(273:A&+888A?CB?8<>:9>C3<CAC95@<&55?9(4?#######
@8JR
GCTAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCTGGACTACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAA
+
@B1BDDFFDHHHHJJJJJJGIDHGIGIJII@BGGB<A?66@DDD5:55@<?<2?:ACDCC:@A??B5>B9>A?CAB@@DDB990<9@ABC89@>CA@CC3:
@8JS
GTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGC
+
@@@DDDDDHHHHFI)7?<DF@C=F@@===87;B:AB6?><ABCBB=?@>@:5??87+2;3:?:>CCCCCCB888>:9AC@8A>?(:?>088?C>:A#####
@8JT
CTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGCGC
+
@@@DDDDDHHHH?D@DDGABCG=B====@@G5?E;>B6=?BCB;?B@@>9??8?2<B::C3>A:@C3?B?8?:@A@C><CCC3>@B0???@>CC1<BB5<0
@8JU
CTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGCGC
+
@@@DDDDDHHHH8@?DBDFB8FCCBBF@AAE';B=E<5>?AAB;=@>@><9,;@+(7CC?@AA::><??88?>:9:::8C>C9ABB?@81(+4?8?@B<90
@8JV
GGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGCGCGGCATG
+
@CCFFFDAFHHHDGIJIJIFHAGGGIJJIJJEGIJIJIFCHHHFDFDD;?BDCDCDDDDDDDDDDDDDCDCDBCD>?>?BBBDDCC@CBBDDDDDDDD<<<
@8JW
TGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGGCCTCCACC
+
CCCFFFFFHHHHHJJJJJJJJEGIJJJJJJJGIGJJJJJJIJIH'93;;A>CAC>@>>A:>?B'5;(:8&0??9<28?>C:2<?9>((9::<&2<8<B?CA
@8JX
GAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTG
+
CCCFFFFFHHHHHJIJJJJDDDDDDDDDDDDDDBDDDDDDDDDCDDDDDDDBDDDDDEDDDDDDDDDDDCDDDDD?BBDDDBDDDACDDDBBDBBBDBBD?
@8JY
CGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATG
+
CCBFFFFFHHHHHJJJJJIJJJJJIJIJJJJJJJJJJJJJJJJJJGGIJIIJHHHFFDDECDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDEDDDDEDD
@8JZ
TCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGCGCG
+
CC@DFF?DHHH??@DDFBF=F@C4=CHA<B5;B6=954;;'9=A?>CA9,<;B5<B33?3>C@@CACC1883:>::4(4:?+3<@0288>:@C+<<>5<9@
@8K0
GTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGC
+
@@CFFFFFHHHHHIDE@FFGAFCE4BFFGEGAA5?E?CD9ABA@@;??AC>?CB@B8?B>AC::@C:?99A1(1:493::<C@C(4<>8<?BC########
@8K1
CCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGG
+
CCCFFFFFHHHHHIHIJJJJGHIGIIJJGIJJIJJIJIIGIIJJIIIJJGIHHHFFFEFDEDDDDDB@BDDCDDDDDDDDDDDDDDCDDEDDDDEDC><<>
@8K2
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHHHHIJJIJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJHHHHHFFFFDDDDDDDDDDDDDDBDDDDDDDDDDDCDDDDDEDCAD<@5
@8K3
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHHHHGIJIJJJJJJJJJJJIIJGIJJJJIJJJIFIIIIIJJIJFHHHHFFFFDDDDDDDDDDDDDDBBDDDDDDDCDDDEDCCDEDCCBDDB
@8K4
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHHHHIJJJJJIJJJJJJJIJJJJJJJJJIIJGGJJJIJJIJJJHHHHHFFFFDDDDDDDDDDDDDDDDDD@BDDDDDDEECDDDEDDDDDB>
@8K5
AAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGG
+
CCCFFDFFHHHHHJJFHIJJJJIJIJJI';-)>CCDEH>A??CC>BA3?@559,8?@;@+8@3>:(38-9++0::3((,:>ACCBB?<:A34:3(::9+3?
@8K6
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACGGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHFHHFGIHIICFGHGHCHFCE@FHIIIEHJGADHJ>HGG<EAEHHHEEEFFEBDDDDBBBCDACCDD@@<<BD@CCACDDCACDDC>CDB@<B
@8K7
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJGJJJJJJJJJJJJJJJJJIIIJJJJJJHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEDDDDEDDDDDDBD
@8K8
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJJIJJJJHHHGHFFFFDDDDDDDDDDDDDDDDDDDDDCDDEEDDDDEDDCDDBBD
@8K9
CGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGGAAGGACACGGTCCAGGTCCTCCACC
+
CCCFFFFFHHHHHJJJJJJJJGIIJJJJJJJFGIJJJIJJIIJH'936>ACCCC>A:>>:5;=28;(+555<BBB&5>?<18C?9@28>A@C44::>C39A
@8KA
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCAGACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHGHHHIJIJJIJJJJJIJJJGHJJJIJJ<FHIJJJJHIIJFIJJJHHHAEFFFFDDDDBDDDDD(:?ADDBB@@CCACDEDDDDEDDD@>@<@
@8KB
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
@@@BDDFDHHGHHJGGIGGGCFEHIJIGIIIGHGGIIHHGGBBACFCGGDGHGHHHGHFFBBDB@BBBD?CDDD@?>BDDD@CCDDEEC:CCA@@@B9955
@8KC
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJIIJIHGIIEHIGGIIIIGIIIJJJJGJJEHGEHIIIJJJHGHHGBFFFCDDDDDDCDDDDDDDD>BDDDCCDEECDDDEDDDDDDDB
@8KD
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHHGHGJIJJDIJJJJJJIJIJJJJJJJIGIJJJIJJIIIIIJJIIGIFHEHDFFDDDDDCDCDDDDDBBBBDBDCDDDDDCCDEDDCBBDDD2
@8KE
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIIJJJJJJJJJJJJJGIJJJJJIJJJJJHHHHFFFDDDDDDDDDDDDDDDDDDDDDDDEEDDDDEDDDDDDDD<
@8KF
CTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGGGGACGTCACGGTAAGGACACGGTCCAGGGCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGG
+
@@@DDDDDHHHHHIIIIII6@;=BFA@CF;@)7=@;8='3=')6&5<?5@+2?9:+(380;28<A:<&+88<?<C@888::>3>>(>4>+:?B(82<::>C
@8KG
TCTAGGGTCTCAGAGGCGGCTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGG
+
CCCFFFFDHHHHHJJJJJJEHIJIGIGGGIGIBDFHGGG@GHGGHHDFFFDDDDD>@25<@B@BD@@A@ACDDD?CBBBDDDDDDD?CCDDABB@A@BDCD
@8KH
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHHHHGJJIIJJJJIJJJJJIJJJIIIIJGIIJJJIIIIJIIJJJDIICEHFDFFDDDBDDDDDDDDDDDDDDDDDDDEEDDCDEDC>BDDDD<
@8KI
GGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGC
+
BCCDFFFFHHHHHGHJJJJIJJJJJI'3,3(5:::A55(+(3379)8<(37&08?6@(8?:>32?A###################################
@8KJ
CTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGGGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGG
+
CCCFFFDFHHHHHIIIIII6@@CCFCFGH@@;=@@AAE'9?87@5@?@@B8?B@C>?A?7B8?BAAC:@@CCD3<A??ACCCCCC?CAC?ABB8??B>@CD
@8KK
GTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGG
+
???DDDDDDDDDDI6@09?=BBBD<B==@@@8A4;A2;=495=??5=?>>:9?<8<(2;:>?3>A>>A>>>218>AAAAA<A:>(4<?<>7<43>?(8>?5
@8KL
TGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGGCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAG
+
@@@DDDDDFFFFFIIFF)@78=F=B@F;=)8;=)4=-;B6;>3<;?;B,9?>B:9995;(2;(+<&2<8?B(9@(+84:34>3(>:A(4?>822<::@?##
@8KM
CAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGGG
+
CCCFFFDFHHHHHJJJGHIJJJIJJJJJJ4;57==??CE7?7;7;;9A,;>5;=;:?B@<88?:A:8??>B0<B>:?+4>3:>3<B28?@@>@@#######
@8KN
CAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTG
+
CBCFFFADHGHHFJJIGIIHHJHIIJIJG;@;;DEC;?A3=7?@;@AA,5;5;?388?'5+88:@>1(25>2894>A3:CCCC(9A18(:>>>>48A(93@
@8KO
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJJJJJJJJIJIJGJJJJJHHHHHFFFFDDDDDDDDDDFFDDDDDDDCBBD@BBBDEDCDCDD>CBDBD@
@8KP
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
CCCFFFFFHHHHHJJJJIIJJIJJJJIJJJJJIIIIJIJJJJIJJJJJIIHFHHHFFF;ACDDDDDDDAADCDD>>ACDDBBDD@BDEDDDDCDDDDDDDD
@8KQ
TGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACC
+
CCCFFFFFHHHHHJJJIJJJJFHIJJIJJJJFGIIIJIGGIIJB,996.>(;5ACC:>:>>;@??B?CD9>(()928?3>3<A<99+8>>@C:AACCCCC8
@8KR
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJIJJIJJJJJIIJJJIJJIIIJJJJJIJJJJJHHHHFFFDDDDDDDDFEDDDDEDDCDDDDDDDDDDDDDDDDDDDBDDDBDDB
@8KS
CTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAG
+
CCCFFFFFHFHHHJJJJJJGHJJJJIIJJJJI'8,,8@ACCDCDCCA@A@B7?<0><:@?<;@(<?:@:8AA9>28934<(4>CAC39A128:A?:@@8@:
@8KT
CAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGCGCGG
+
@@@DDDDDHH)???D?8?BG<F>CBCGHB;@E;CH,5;;9>??B5>A@<?;B?@B>@C3:>ACC(3<?BB4:9>C>?C>A?CBB<???A:@C88>93<55<
@8KU
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHFHGJJIJFIJJEIJJJJJIIIJEIIJJGJJJJJJJJJJJHHHHFFFDDDDDDDDFFDDDDEDDCDDDDBBDDEDCDDDDDCDDDDDDDDDB
@8KV
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
:?@FF?DDHHHGHJJJIIJJIIGIHIIIIJJJ>@FBGGIFIJJGHIIIJFHGHFFFDDDDDDDDBFDDCCEDD@B@BBD@BCCCDDDDDDD>BBDDD<BB8
@8KW
CAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCACCGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTG
+
@@@DDDDDFHHFB9FHG3;HHGIGGIIIH/;7??C9:@ACCC8>3+557<:(35<BBB(2++52:4<CBBB(2-(:3++4>A39?2<224:ACCC<CACCC
@8KX
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFH8DFHIIJJJGGIIIIHHGGIJGJGIIJIIGIIGDHGHGIJHHGHDFECC?BDDDDDDDDDDDDDDDDBD@?BCEDDDDDDDDDDDBDDBABB
@8KY
CTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGGCCAGGTGCTCCACCAGCTGCTTGAAGGTGGGCCTCT
+
CCCFFFFFHDFHHJJGIIIJJF?AF>.=@=CD7=4.=?3:B';A;69;B??BD1?@:@>8A<5;&0;@BB:(:AA>@CB81<>CCCAC(:@C(+2&(22?A
@8KZ
CTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGG
+
@@@DDDDDFFFFFIIIIII(;7==@;==F7@=@==9=E';B;;=>@=??@5<@5>:2<?;B+2;>@B4>A@AB?@B88<@AA3>:8@4>(:?B########
@8L0
TGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJHHFFDEEEEEEDDDDEDDDDDDDDBDDEDDDDDDDDDDDDDDDDDDDDDDDDDD
@8L1
CAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGGAGGTG
+
?@<DDFDDFHGHHGIGIGHEDHGEI<EEB'4@@.=).=E)=3;;;79/95;9C?B=<<;<8(2:AAAC?B>0+9:A9:3@@>?CDB8A<@###########
@8L2
CTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCAC
+
@@@ADFDFHGDFHIBFEHIIIIAGGHGDGIGGIIIIIIIIC@FHIDEHFFEA@EEBEDDCEDDDDDD@DDBCDCCBCCDDC>BBDDD@BD@<A<ABBDDDD
@8L3
CTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJJIJIJJIJJFIIIHHHFFEEEEEEEDDDEDDDDDDDD@BCDDDDDDDDCDCDDDDDDDDDDDDBDDDDD
@8L4
GGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGCGCGGCATG
+
@@@DDD8A:DDFBIIIEIIFIDBGBFFIIIBFEFF@E;=;>EEDDD>>5;;A;?5@>:>A?B@BBBAAA@>A8>AA9A?B??@BA@@?<?5<9559BB9><
@8L5
GGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGCGCGGCATG
+
CCCFFFDDFHHHHIJJJJIIJJJIJFHJJIIGIGGIJDHHHHHFFFDDADDDDDCDDDDDDDDDDDDDDDDDDDDCCCDDDDDDDDDDDDDDBDDDD><BB
@8L6
CAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGGAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTG
+
CCCFFFDDHHHHHJJJHIJJJJJJJJJJI'5-7=C;=?C;=;?>??<A'5>5>;,85827&072<28<<59+8>::<(4>4>?9<B22<4:?:@:8C@C##
@8L7
AGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTC
+
B@BFFFFFHHHHHJJJJJJJJJJIIIJJJJJIJJJEIJIJJJJHHFFFCDDFEEEEEDEDDDBDDBBCDDDDDDDDDDDDDDDBDDDDD?ABBBDDDBBCC
@8L8
GGTCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCA
+
B@+ADFFFHGHHHIGIIJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJJHHHHHHFFDDDDDDEDDDDDDDCDD<<B@DDDDDDBDDBBDDDDDDDDDDDB
@8L9
CTTGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGG
+
@@1=BDDDFFBHHGIHGIB77;F@@DHEG=@;@;7=EH4;B;>>BBBBBB<<@C@AB<?5;285@@?:::>@AC3888?C@CCCC8>(93:?<888?AC>C
@8LA
CCCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAACCAGCTG
+
@@@FFFFFDFHFDFHIJIJJIJJIGJGGIIGJGIIJEFFGIIJJGIJJJJIGFBAD;;CA@@BCCBDD8;5>BDDBBD<(82(+<@8<@<:AA>(2<AB::
@8LB
GGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJIJJJJJJIJJJJJJJJHFFFFFEEDEEDDDDDDDBBBDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDD
@8LC
GGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
B@@FDFFFHHHFFIIIGIIIJIGGHIJIJJJHIJGJJIGIJIIIIHIHFDDFEEEDEDDDDDD=BDDDDDDDDDB?BDBDD>BDDDDDDBDDDDDCDDDBB
@8LD
GTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCT
+
C@CFFFFFHHHHHIIEHIIIIIIB'<;@DC@@@C@C)7=7?A>5;36>>;;<@?B8?B@C:83<;B2<8::A4+:>AA?CBAA?>@C>A(8A>C>ABB8A<
@8LE
TTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTG
+
CCCFFFFFHHHHHIIIIIIII7A<@@FFFCG;=7==7=:E';A66=9>@B:@,9?@C@8?B@B08>@CC4:@CCC<AB8<?A@>A@>8@:A+>@B8A0?>@
@8LF
CCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGAC
+
CCCFFFFFHHHHHJJJJJJJJJJHIJIJJJIIJJJJJJJJJFHHIJJJHHHHHFFDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDD
@8LG
CGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGG
+
B@CFDDFFGHGHHJIJJIIJGIJJJIJ-;5=ADAC;C?AC??7??<3?B?CBBBBDBB8?BCC>AC@BD(2544<>@ACCC3<A<?B::?3@:2>AC?CBD
@8LH
CCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGAC
+
CCCFFFADHGFHFIIIGIIIGHIGIGIGIGH<FGEEGIIH/5CFAGHJHHEHED9ABDDDDDDDDDDDDDDBBBBAA>CCDDDDDCCCC<??BDB8<CDDA
@8LI
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
CCCFFFFFHHHHHJJJJJJJJJHIJJJJJJJJJIJJJJIJ@FHJIJJJJJHHHFDDDDDDDDDDDDDDDDDDDDDCCDDDDDDDDDCDDDDDDDDDDDDDC
@8LJ
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
@@7DDFFFGHGHHGGGIGIJIIGHIJIIIGGGHEEIIGGIHHIJHIDEIJHFHFCDDBDDDDDDBDDBDDDDB@DCCDDDDDDDDD<??BDBDDBDC@BD<
@8LK
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJIJJJJJJJJJIIFHIJJJJJJJHHHFDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDCDDDDDDDDDDDDDC
@8LL
GTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGGAGGGCGC
+
@@@DDDDDHHHH:@6B*9?@<F<BB8==;@A';A6359=ACCB5;?>C>?CB=?2<@CCCA3>@>C??B<8?>A?A>3(>@>+:?@??<?:>AC2<@B3>0
@8LM
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCG
+
CCCFFFFFGGHHHBHJJJJJIHIIJIJIIJGIIHIJJAFHIIJIJJIIHIJHHFDDDDDDDDCDDDDDDDDDDDDCCD@?CDDCDCC@ABDDDDDDDDDCB
@8LN
GCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTT
+
C@@FFFFFHHDFGIGGDGHIGHHIIIEGEGGD?FHGH>=BFDHGIIHEFCDDBDDABDB??BBBDDDCCCCCDDDCCDA??DD@BBA??BDDDDDDDDCCA
@8LO
ACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTG
+
CCCFFFFFHHHGHJJJJJIJJJJJJJHIIJJJJIJIIIIJJJJJGHHFFFFDDDDDDDDDDDDDDDDDDDDDCDDDDDBDDDDDDDDD@A?ADDDDDDDDB
@8LP
GTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTC
+
CCCFFFFFHHHHGJJJJJFIIGGFIHIJIJJIGIIIJIIIGGDCGBGB39;>CDDCCC@C:C>>>8=@?3?355508<><<8@4429?<08<934<>>4>>
@8LQ
TCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTG
+
CCCFFFFFHHHHHJJEGIIJIIEHIJJIIEIJJHJJJJIJJJJJJJJJJJIIHHHHF@CFFEDEECD?CCCDDDD@B@DB&5044@AC4A>>:AC>:590<
@8LR
GCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGCGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAG
+
=??DDDD?:<DCF:@DFFB?CEG@@CGFFF@;GE:?B98BD2B@8CFFC@-.=ACAEEDDD'3>=8'08<4?;@@599?9A??<+:(>@>259&5@B@###
@8LS
CCCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCCCTCTTCTGTGTCTGGGGGCGG
+
CCCFFFFFHHHHHGI<GFHIIJJJIJJJHGGHGIJFHIJJJJJJJGIGIIJH>CHFFFEDEDACEDDDCD?BBDB##########################
@8LT
GGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCA
+
BCCFFFFFHHHHHIJEHHIIIIFIIGIJJJIEGIJJJIJJIJJIJJJJJCEFHHHDFFDDDDDDDCDDBBDDDDDCDDDBDDDDDDDDDDDCDCCCCDDDC
@8LU
CCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCA
+
CCCFFFFFHHHHHJJFHIJJJIJJJJJJJJJJ;GGIIJIIIGGGIJJJIJJIJIC9>3(;>>A:AC@>@C###############################
@8LV
CTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGG
+
CCCFFFFFFHHHHIFHIJJIJJIJJJJJIIIJGIJIIGIJIIJJJJJJJJIHHHHHBCEFFEECEDECCCDDCDD<@BB5<0(:@CA(:>>:@@@######
@8LW
CGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCCCTCTTCTGTGTAGTTGGACGGCCCGGGGACGAC
+
==<AA<A;??AA0?A72@A7CBC+<@B?BA<A<ABBB<?A==9=?AB<A<97>A<=A;;AA@#######################################
@8LX
CCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGTC
+
CC@FFFFFHHFHFJIJGIJIIGIJJJIIIIIJJJ@DHHIJJJJIJIFCGIJAHHHHHFFFFFEEEDECCBD@BB###########################
@8LY
TCTCTGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCAAC
+
:+=BD??BFFD?F<FGFI<??EE<;88CEFFCFGIE@*98BFEFIIIICDE>ACEC;CEDB);@>;6@B???9;AA@>@:9>:?#################
@8LZ
TGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCA
+
@@@FDFFFDHFHGGDHIIJGIEGGIFGHGHIJJJJJICHGIF@GGIIIGJ;CAAHEHEHF@DCFFDEEBDDDD-5))234>CC##################
@8M0
GGGGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGG
+
@@@DDDDDHFFHHIGGEBH<EH?EEC:@B?DH)06)?@(<(==;@';@AH9A9;@:;?2;>@@(;>>A>@(5:?<,5<A>>(+>@(3<@(4:@@@BB####
@8M1
GCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJHIJJJJIIJJJJJJJJIJHHHHHHFFFFDDDDDDDDDDDBDDDDDDDDDD@CCDDDDDDDDDDDDDD
@8M2
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTG
+
@@@FFFFFHHHHHIEGE@FFHIGGIGGIIIIIIHIIFHI=FHGHIIIIIIHFEHBFDFFCEEB;;;=?8??@CBB9><>CBC>CCB:@CCCCBBBBB>B@@
@8M3
CGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGA
+
@B@FFFDDHFHHGJIJJIJJGIIIGIIJGHBHIJIIJJJIIIIJIGHHGFHF@CE?CDAAD?CDDBCB=B?ADDDDDDBBBBBDBBB8ABD>>09CBD@?9
@8M4
TCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTTTGGCGGTGGGCG
+
@CCFFFBDFHFA;FFGHG@FGGHIGHIIIGCCGCGI@FHIGIIGGEHIEHIIH?EFFEFFFFDACC@DDCCBDDBD#########################
@8M5
CTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCCCTCTTCTGTG
+
CC@FFFFFHHHHHJJIJJIJJGIJJJIJFHIJJIJJJJGHIIIJGJJJJJJJJHHHHHFFEFD@CEEDDDDDBCDCCDDDDBDDDB###############
@8M6
GCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCCTCTGTGGCGGTGGGCGTCTCCGCAAGGG
+
@@<AD:DDHADHDHIIGHEGA@EBGHGHGADE@C9D?FDCHBD;FCCAG@GC@FC>A@=;@########################################
@8M7
CAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGAC
+
CCCFFFFFGHHHFIGIJJJJEHIJJIJ?DFFHGHGIJIBGHGHC@HHIJJJHFFFFFECCE;>@CC>@BBBDDBC@CCDDDDDCACDCDDDDCCCCCCBD?
@8M8
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAA
+
CCCFFFFFHHHHHJJJJJJJEGIIJFHIFHJGJJIHIJJCGGGFHIGGJJCHHIIGHHGEFFFDDD>BDDCDDDDDCCCCDBBDDDDDDDDDDDBDDDCCD
@8M9
TGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCGG
+
CCCFFFFFHHHHHJJJJJHIHIJHJJJJJJJJIJJJJJJJJHHJJJJJJJGHFFFEEEEEDDDDDDDDDDDDDCDCDDDDDDDDDCCDDDDDDDDDDDCB9
@8MA
CCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAG
+
<@@DBBDDF?FFHHGIIGEG9D?3FAD9?C?BDBBFEGIBF)@<@CFH@GFHE8;CAEEEB??CB<@?==CBCCC?<4>CC>C8@@BBBBCCCCCCB?C?C
@8MB
CGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJGIIIJJJJJJJJJJJJHHHHHFFFFFDDDDDDDDDDDDDDDDDDDCDDDDACDDDDDDDDDDDDDC
@8MC
GCGGAGTCTCCGCTTTGTGCTGGGACTCTGCCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGGAAGGA
+
CCCFFFFFGHHHGJJIIGIIJJJIJJJJJJ3DGHGIIJJJIGGIJIJIJJCGHHIJJJJJJFDD&5):::@@@A###########################
@8MD
CCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTTTGTGTCGGTGGGCG
+
B@@FFFFFDHGFHJJIHGEGHGIAHGIIIBGHII@H>GHGGHEGG@HGHJGGCAEHFFEEDFC>CEDDDDDBDDBD#########################
@8ME
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTG
+
@@@FFFFFHHHHHJJJJJJJJIJJIJJJJJJJJJJJGIJIJJHIJJJJJJJHHHFFFFFEEEDDDDDDDDDDDDDDDDDDDDDDDD>CCDDDDDDDDDDDC
@8MF
CCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGA
+
CCCFFFFFHHGHHJJJJIIJJJIJIICFHCHIGIJIIJJJIJGHBFHJIJJHJHHGHHHFFFFEDCBBDDDDD??A4>CCCDBBBDB>DCDDCDDDDDC?C
@8MG
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGT
+
:?1=BDDDHFDBFHIIICEHIEGHEHGIFGFBGHGBFBGGEFEHFAH;DGIGHHFHEEFFFFDCDEEDACBB?B###########################
@8MH
CTCCGCTTTGCATTCTTCCGCGGCTCCGTGCGGAGGCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTTACTC
+
CCCFFFFFHHHHHJJIJIJ33@FEIJIGHGEIJEI'?AEH>DEDDCCCCDDDB?ADDDDCDDDDDCCC@B8>CCDCACDBDCDDCC::??###########
@8MI
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGTCA
+
CCCFFFFFDHHHHIIEHHGGGEBHJGHGCIIJIGHJIJIEGGEGIIIJJJCGFHHHHGGF;;BEEECEDDBDD############################
@8MJ
AGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGT
+
==1AAA?>A7CA1?CBBB+AAA8AA=:?ABBBAAA8=AAAA;>BA';=<>AAA@>>@@>@>@@======??;>;?=;<=<?=???;;=?;?##########
@8MK
TCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGGCCTCCACCAGCTGCTTGAAGGGGGGCCTCTGG
+
???DDDDDDDDEDEEIIDIA7;6=4=.=787777=7)-:,;@;A@3;;5;=,2<>A:=??#########################################
@8ML
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACC
+
CCCFFFFFHHHFHHHJGGHGHHCHGGHGEFFGHIJIIJFHGHIJ=EHEHH?EE<BA>AA@?=;?CCCCDCD?92<<?98?@8<-5>>CBCDD>A:@>AAC@
@8MM
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGCACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACN
+
@@<DDFDDHHFFHIJJIIIJHIIJGEHJEFHHGIDFDFHGJEIICGGIEHHFBDF(;@@BADBDDDDDDDD8?<@??BBBDDDBBBDDBDCCDD>CCCCC#
@8MN
GGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCA
+
CC@FFFFFHHHHHIJIJJHIIJFIIJEHHJFHIJAHGIJJIJJJIGIII@EEHHHBDFCDDDDDDDDD?BDDDC@CDCDBCDDDDCB8?CBCD>@CCCDDD
@8MO
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGTTCTTCTAGGGTCTCAGAGGCGGGTGTTCCTCTT
+
@C@=DDDFHHHHHIIGHII@FH=GIIGIIBHIGIIIEDFHIIIIGHIIIGGDHHHGHEFFFFFC>AB(-;ACDDDD>ACACCDACDDDDDD-5)(+4>>AC
@8MP
TCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGG
+
CCCFFFFEHHHHHIIIIIIG?@;<@CF@FGADA===7=E=?B2>A8;@@@B8?<>A>A9A;@?@;C43+:CCC>(38(2<:4>:>@?44?3>?0828AA>C
@8MQ
TGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCGG
+
@CBFFFFDHDHHHJJJJJFHIJJGHGGJJJJJIJIIGIBFG==FGHHJJIHHFFFEEEEEDDDDDDDCDDCACCDCDCADDDBDD:@C@CCBDDDDDCCD<
@8MR
CTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACCAGCTGCTTGAAGGTGGGCCTCTGGG
+
@@<DDDDDDHHHHIFIIIH@@;8B@C@FC)=;))77=<,;B?C<3>;?=?89<>>:A3(&5(+7@AA4>C>@A<<?<8<>>C>C<1:AC############
@8MS
CGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGA
+
B@@FFF?DHHHHHJIJJJJJIJJJJJJJIIJJIIJJJJJGIJJFGIHHHHHDCDFDDCDDDCCD?ADD@?ABCDCDCCB?BBBDDDDBCBDDB9BDBDC93
@8MT
CAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACACGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAG
+
CCCFFFFFHHHHHHIIJJJFIJIAGFHIHJJJIE?DDDFBFEGIJIJJDHEHACDFD;A<CEE@BDDDDBCDCDCA@BDDDDDDDCCD?CCDDDB?ACDCD
@8MU
CTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGG
+
@@@BDEFFHHHHHIIIIIIAHGGHIIIIIIIIHEHIIHIGIIIIIIIIGIIHDHHH;BEEFEECED@CCCDC5@B?@BB&50343>CCDDD@>>@######
@8MV
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGT
+
B@@DFFFFHHGGHJJIE?GHIIIGIIJIIIJJJIIGGCFGIJIHHIIDHEIA?EH>EFEFEEDEEDEDE<@BBDD55&4:>AC:AC###############
@8MW
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGT
+
CCCFFFFFHHHHHJJIJIIJJJJJJJJIHIJIJJJGIGGIJIIJGGIJJIJJAEHHHFFFFFCCEEDEEDDDDDD&5058A>@@C################
@8MX
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCA
+
CCCFFFFFHHHHHIJFHIJJJJJJJJFHIJJJJGJJIJJJJJJJJJIHIJCHHHHHHHHFFFFEEEEEDDDDD5>5:AACC>C>A@AAC:5<08>1:9992
@8MY
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCT
+
CCCFFFFFHHHHHJJJJJJIIJIJJJJJJJJIJJJGIJJJJJJJJJJJIIIJJJJJHHHFDDDBDDDDDACDDDC?@BDDDDDDDDDDDDDCDDDDDDDDD
@8MZ
CCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACC
+
@;?D=;DD??C?CFHGGE@EHGDHDEBB;?D?CD;DG?AD;D;2B=@@=FGIIEC>E85(5;?5=A1>@68;/3<+9(+9?:@:>@C?BBB<<9>CCC>A8
@8N0
GTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAG
+
B@BFFFFFHHHHHJJJJFHFIIJJIJJJFHIIJHGIJJJGGIBGCHIIIHHAAAEFFFDDDDDDDDDDCDDDDDDDDCDDDDDDCDDDDDDCDDD>AACC@
@8N1
TCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGAC
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJIJJIJJJJJJJIJIIJJJJJJHHHCCFFFFFEEDEEDDEDDDDBDDD)504>A>@>A>:3444:3<08>24
@8N2
GGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGACAGAGTCCCAGCACAAAGCGGN
+
CCCFFFFFHHHHHIJJJIIIIJHJJJJJJJJJJJJJJJJJFHIJJJJJIHHFFFFFEEEDDDDDDDCCDDDDDDCDDBDDDDDDCCDDDDDDDDDDDDDB#
@8N3
GCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCN
+
@@@FDDDDHFHGHIIIGIIGIIIIIIIIIIIGIGGGIBFHGGEHCGHIECEHEDDCECEECCDB@BBDDB@DBCD@@9509?ACDCB@ACDCCD<>BDDB#
@8N4
CGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJHJIJJJIJJJJJJJJJEHHHHFFFFFDCDDDDDDDDDDDDDDDDDDDDCD>CCACDDDBDDDDDD#
@8N5
GGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCA
+
CCCFFFFFHHH>FIIIGIJIIJFFHHGIHECFGIIIJI>GIH<BFGIIJFGE=EGHJJIJFGCGGGGIBCHFE@DEC?AC>;ACC9AB(3<@DDC><@BAB
@8N6
AACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAG
+
@@@DDDDDCFFFFFA<2CGGEGEBEFDFCDGIC;08??FCFC8?BBFFII@@;=;@EEC2??E;?6?;?>>B6@AABABA>5=<?@?5:????@<B>@A<4
@8N7
TAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTACTTGGCTCTGGGAAGAGCT
+
@@@BDBDDDFDB?FBHHEHG+<@FDHI8:DG9B*:@D9DDG>DHIFH<FGGHCAFH9CEDEHHHFB:;;6;>3;6;-;=5;->((,(,5:(5:38>??A?>
@8N8
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTT
+
CCCFFFFFHHHHHJJJJIJJIJJJJJJJJJJHIGHIJJJJIJJJHIJJJIJGHHHHHFFFFFFCEEDDACDDDDCCDDCDCDEDDDDDBDB##########
@8N9
CGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGA
+
@@@FDDDDFHGHGJJGGIAEFGHIGIIJGBGFHIIIGEHGIGCG@CEBEAHF7?B??CC@BCCDBBCDBB<ACCD>CD>BB??BB<B?AA<9>BD?CB:@C
@8NA
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTT
+
CCCFFFFFHHHHHJJJJJIIIIIIJJEGGIJBIHIJJJJJJIJIGIIJIIIJHFHHHFFFFFFECEDDACCCCCACCDDDDCEDDDBDDDD##########
@8NB
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTC
+
@@;DDFFFHHHDHJJJJJJJJJJIJJJIHGIIJ>H@FHJJJJEIJJIJJJJHHEHFFFFFFDCEEEDDDDDDDDDCCDDDDDDDEDCDDDDBB########
@8NC
CTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGGCTTCTAGGGTCTCAGAG
+
@@@FDB=AADAFAFFHIBGGIIECHCFDEHGE@EHIICGIGBCFAE<E5?CB><A@BBA>CAC:A@959?>@>@CC>@9@>?<&9>A?AC@A?+9?CDCCC
@8ND
CATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCC
+
BC@FFFFFHHHHGJJIJJJFIFIJJJGIIIJJIIIJJJCHFHGIJJFHHHFFFFBBBDDDDDDDDCDDB@BDBB??CA>9@9BCADACAA>>@CC@<>BD>
@8NE
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTG
+
CCCFFFFFHHHHHJJJJIIJJJJJJJJJJIJJJJJJFHIGIIJJJJJJJJIHHHFFFFFEEEDDDDDDDBDDDDDDDDDDDDDDDD>CCCDDDDDDBDDDC
@8NF
CCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTC
+
@CCFFDFFDCFHAGEAEGGHGHIEGIGG>BG9?DGHA?AEHHIFACCBB//9?;ACA>B:@DD@CAA>:2<ABC@ACCAC:CCDC?@?9<C:@@CCB?A##
@8NG
CGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGA
+
C@CFFFFFHHHGHJJEIJJJJJIIJJGGIIJGIJJGHHHIIGIIGIJJGJIEECACDFEFFD?=CD@BBDDDDDDBDDDDDCCDD>CCDDDDBD><>BCC@
@8NH
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
???DDDD8CD:CDD?:@:9C9*0):?BDB9B?DAD4DEIA0B5@AA@;A<?DA5(;(;3;?88>A9:;:>>??<A:4>:>A>>9>:8>29<AAA>A#####
@8NI
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTN
+
BCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJGHIJJJJJJJJJJJJHHHFFFFFEEEDBDDDDDDDDDDDDDDDDDDDDDDACDDDDDDBDDDDD#
@8NJ
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGGCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGG
+
CCCFFFFFHHHHHJJJJJJJJJHE1?F)?00?9FA;6FC448@F=CH4@7@':;?<?,.53,82;&8??@-5&9@3:9:(+:?(28?434:A((4(4>?B#
@8NK
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
CCCFFFFFHHHGFIIJIIGIJIFGHIIEHGGGGIEHGIIIFGGGEHHHAGH>HEEFD>;??8=:;5:@AC)55;B:4<@>:@B8?BC@@CCDDCC?@:?B#
@8NL
AGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTT
+
@CCFFFFFHHHHHJJJJJJJJJFHIGJJFIJHIJIJJJGIHIIJJJJIJIJJJJJHHHHFFFDDDDDDACCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@8NM
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTG
+
BCBFFFFFHHHHHJJJJIJJJJJJJJJJIJIIIIIJ?FHIJJJJJJIIGIGH<EDFEFFEEDCAD?BB?BB@DDDDDDDDDCCDDD@CCDDDDDDDDDDDD
@8NN
GGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCT
+
CCCFFFFFHHHHHJIIJJJJIGIIJIIJJIJIJJJJFGIIIJJ@EA=D9>;>CCD>?=BD>>@CDCDE@@CDBD?@@B-2<<55)9+93>C0505?@:9>:
@8NO
CGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGC
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJIJJJJIIIJJJJJJJJJJHHFFCDDDCDDDDDDDDDEEEDEEDDDDDDDDDDDDDDBD@D@DDDDDDCDDCDDC
@8NP
CGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGC
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJIJIJJJJJJJJJJJJJJHHGDFAD?CCCDDDBDDCCCDEDEEDDDCBBBBBD9<?<@D<B8ACCD@@BBDDDC>
@8NQ
CGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGN
+
CCCFFFFFGFHHHIJFIJJJJJIJJJGIIJIJJJIIIGHHGHIIJJIJJGIEEHHHFFFFFCCCDBBDDDDDDBD>BDDBDDDCDCDDDCCDDDDDDDCD#
@8NR
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACC
+
@@@DDDDDFH1<CGHBGBEGE@=FFGHH)BDGGI<@4B;CFHFC7=@=?CHEE@CC@@>B?;?BC;AACCB(5(8<29?BCBB993<C<<>CCB:::C::2
@8NS
ATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGA
+
@@@DFFFDHDHHDHJJGIJIIGIJIIJJIIIGIJJIHIGEHHFFF>;?CEEEEDDDC?9?B?BBCD?ABDB9A<AC@>CDDD?88?B<@BBC<BDD@DDD#
@8NT
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCA
+
CCCFFFFDHHFD<BEHCDG<CBGGGGDEH@GCG@DGGFDHDGIG@AFCGEGIIIFCAHBD6AA;A>>@>@@888=-5>C34:@C@ACC<::@AA(<A99A4
@8NU
GCCACTGCTGCGGGAGAACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGCCTC
+
?;?DBD?ADDD@D))1):EEB9CBDDDI:@28:DD'555=).=A=?;99@=@?>5=8/'80233>A?>39<A#############################
@8NV
GCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTC
+
CCCFFFFFHHHHHJIJFHIJIJJJJJJJJIHJJJJIJIJHHHHHHFFDDCDDDDBDDBB@DBDDDDDDD;BCCDD@CEEDDDD>>BBDDDA?@9<5<?ACD
@8NW
GGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGGCT
+
@@@FFFFDFBHHFIEEAAC@BFBFGICCFHBHEHGFAG8=EFHFGDFD><??BC:B182;&)23:>C&005<@>A@::>C3@@>0<@BBB###########
@8NX
GGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAG
+
@<@BDDDAAHHDDHIGHE@GHIIIIIIGG@BGGGIIIIIIIIIIIIIIHHH?EDBDCACDC??BDDD8<59:(>@@CD@@?<8?@B@>A@<B>DC?9>C?B
@8NY
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAA
+
@C@DDFDFHFHDFJIGCHIHGIEGG:EGECDFHHIIIDHCGGFBFCFFCGIGGIJJGHHFDFFCBDBDDDAACDDDCCCCDBDDBD9>>CDDDDDBCCC::
@8NZ
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACTCTAGAAGACCCTTGCA
+
???DADDDD<+<CEE@B:;:;EEEEAE;CDBD>DDD)?)B*?*/?ABD;-;55-;7C<49<96(5-;5;>><3/85503>AA3>(4+>>(>AAA??>9<>:
@8O0
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCA
+
CCCFFFFFHHHHHJJJJJJGHIGIJIJJGJJJJJJGIGHIJJJJJIGJJJIHIICHHHHFDDEDD@CCDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDD
@8O1
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACC
+
CCCFFFFFHHHHGIJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJDHIEHHHFFFFDDEEDDDADDDDDDDDBDDDBDDDDDDDDDBDDDCDDDD:CCDDDD
@8O2
CCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGA
+
CCCFFFFFHHHHHJJJIJJJJJJJJJFHIIJJJJJJJJJJJIHGHIIJJJJJJJJJHHHFFFFEDDDDDDDDDDDACCCDDDDDDDDBDDD>CCDDDDDDC
@8O3
CACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCG
+
@<;DDDDD:?BHFIIIIIIIIIIGI<AABDEECCCBB@C>BBB=BB?B@ABACC@?A<BB5;<CCCCCC@>;5;58<CCACCCCB99ACCCAA?A<ABBB5
@8O4
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCT
+
@@@FFDFFHHHHHJGGGIJFEHIIIGGIEIJJJIG?GGIHIJFIGIHJIIJFHIIIFGFFDDDBDDCDD:@CCCC@?BDDDDDDCDDDDDDDDDDDDDDDD
@8O5
CTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCA
+
CCCFFEFFHGHHHJJGHIIJJJJJIIJIFHFFBCDDDDBDDDDDBDDDBBDDDBDBDADDDDDDDDD;;BCCCDDDDBDDDDBDCCCDDCDDDDDDDDDD@
@8O6
GCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTG
+
?@CFDDEFDHDHHIGIIHGI8@EFHDHAHGIG>>B>?@?>=BDD??BDDBDDDD00?<B<@BDBCCB?C?0&05?ACACCDDB>9@<AACA@@>>>?AC99
@8O7
CTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAG
+
@@CFFDDBFHFDHHGEIEGGGIGIFJ7AFGIJIGGHFEFDDBDDDDDDDBDDDDBBDDDDDDDDDDBDDDDCDCCBBB5<@DDDDDCBBB>DBBDDDDDCC
@8O8
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACC
+
CCCFFFFFHHHHHJJJJJJJJJIJJIJJJJJJJJGIJJGIJIIJHHIIHHGFFFFEDEDDBDBDCDDDDDD?BDBDDDDDDDDDDDDDDDDCCB>CCDCDD
@8O9
CGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGA
+
@@@FA@DBDDFDHCHGII<EHHGGHFHIIF@FIDIE@G;8=DA@DEE>EE>@.;;;??,5?C=AB?CBBB?A(4:>>C@@A8<?B>?0@AB5><@C<?:39
@8OA
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAA
+
CCCFFFFFHHHHHIJJJGHIIIIJJGHIGIJIJJJJJJJJJHJJJJIJJICHHJJIHHHFFFFD8>BDDACCDDDCACDCDDBDDDB>CACDCDBD?CCDC
@8OB
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAA
+
CCCFFFFFHHHHHJIJIIIJGIJJJIIIGIJEHIIICGIIIGGHIJJIJIJIEHGIGEE@DFFDABB?C<CCCCBC>>CCDDD<@BDBDCC>>@?B<?9@>
@8OC
CAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGG
+
@@@DFFBDD=FFHIGGGBHHHGHGCCF>FHCHHGGGGGHII??BFGIDGBAAADACCBDDB@?<55>BB<BBBB?B@BBDBC9<B?BBDDB08AACD@?9<
@8OD
TGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCG
+
CCCFFFFFHHHHHIJJJJJJJJJJGIJIJJJJJJJJIIIIJIIIIJGHFHHFFFFEEEEDDDBDDDDDDDDDDDBDDDDDDDDDDDDBBDDDACCDDCDDB
@8OE
CAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCC
+
CCCFDFFFHHHHCGGHHIJJJJJJEHIJJJHIJJJIFHIJJJJJIJIJJJJJJGJJDDDDDDDDDDDDDDBDDDDBDDDDDDDDDBDDDDDDDDDBDDDDD
@8OF
TCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACC
+
@CCFFADFHFFHGCF<GDHHJIGHGHIIJFIFHJGII4BGGIJJIDII>GEFHFEIGD;@BDDDDDDDDDBB59<?BBDDDDB@@B<ACBBD?>??8@BBB
@8OG
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJIHIJJHHHFFFFEEEEDDDDDDDDDDDDBDBD@DDDDDDDBDBDDDACDDD@CDDDDD
@8OH
CGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGA
+
CCCFFFDDFFHHHEIJJJIIJJJGHIIJJJIGHIIJEGHHGIJGIGHHGFHFFFFDDCDDDDDDDDDDBBADDDD>CDDBBBBD?BDBDDDDDDDDDDDDA
@8OI
GCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACAC
+
@7?DDDDBFDDFF2:AEF@CGEGAGI>FFBGFIAB?<F@BDEFI<DA8==;=AE;CAEB7@?B>>(;>?>A>ABA@@>:>AB@##################
@8OJ
CATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCC
+
@@@DDD1:DA:@DDDHGEG?AHG?D=GFB>FGHIII@HII)@FEGGHEEECDEB;33=5;CCCCCC=??@<?<>??>BB<99>??C>991+:>CCC@BBBB
@8OK
GGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGC
+
CCCFFFFFHHHGHJJIIJJCFHGHIIGIIIJIGBGHIGGGJJIIJIJJJIJJH>A=BBBFFDEEDEECCCD=ACCCDCCCDCCACCDDCABDDDDDBD09?
@8OL
GAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCT
+
C@@FFFFFHHHHFHIJJGIJJIIJJJJJJJJJJJJBDHHIJJIJJJIGGIJIHHGHEFEFFFFDDEEDD5?ABDBCEDDDD>CCDDD<CDDDDDDDCCC?A
@8OM
CCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCCCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTC
+
CC@FFFFFHDDHHIIIGIJGGIIGFGHGIGGIIIJIJGEFHJJJJIEBFGIGGGJIJIHEFDBACCDCEBCDDDB<?<CBB:84<8<CDDCDBCCCC@A<?
@8ON
GCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJGIIJJJFIJJIJJJIJJIJJJJJDGGIJJJIIJJHHFFDEEDDEDDDDDDBDDDDDDABCDDBDEDDDDCCDDDDA
@8OO
CCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGTCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGT
+
CCCFFFFFHGHGHJJJJIJJFHGGIJJGIJJGIIJI11CDGGIIJIGIIJJIJJBFHHGIIHIGHFFDDDDCDDDDCCDD@BDBCC?@4<>@BDDA@CCA:
@8OP
CCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCT
+
@<@FDDFBHFAHAFEDGFGIGFGGIIBHIIDDEFGG;@G/?BFGGIIIIFEF3C3=DC).=CEFFFDE;9>A6?=AC??######################
@8OQ
GTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTT
+
CCCFFFFFHHHGHJJJJJJJGJGEGEHIJJIIJGIJCHGIIIHI@GIJJHIJEHGJIICECHFFFFFDE@CCDC@?CBBBDBDCDDDDD@BB@C@9BBB88
@8OR
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCC
+
CCCFFFFFHHHHGJJJJJJJJJIJJFIJIJJJJJJJIIIJJIJJCHGHHHHFFFFEEEDD;B?BCDDDDDDDDBBBBDDDDD9>BD9?CB@ACDDCBDDDD
@8OS
CTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCT
+
CCCFFFFFHHHHHJJJJJIJJJJJJJIJGFGHIIIIHIEGGIJJJGHIGJIJJJGIHHHHFFFDDEEDDDDDDDDDCDD:ACDDD@B<BBDDC>CCDCDB?
@8OT
CTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGG
+
1=@DFFFFHHHHHJJJGGIIJJ:@FHIJJIJIJJIJGCGHHGIHHHHFFFFFFEEDEDCCDDDDDDDDCCCDDCDDBDDBDDDDDDDDDBDDDDDDDDDEA
@8OU
CGGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTG
+
CCCFFFFFGHHHHIJGIJJJJJJJJBGHIJJ?FHIJGIJJJJJJJGHHFFFDDDECDDDDDDEDDDDDDDEEDCD@CCDDDDCCCDDDDBDDDBDBBDBDD
@8OV
GGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAG
+
?@@DFBDFHHHDHEHGFHGGDBH:GEGIIBHGHIIJGGGGEGHIDEH@>CH?>BBBCB@B=CB?A?@3<9<:>A>A?B+228?8988:(9@B@DDDD>>CD
@8OW
CTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACAT
+
CCCFFFEFGGFHHIIJIJGIJJJIJJJGIIGJIGHIJEGIIIIGGIJIJIJJIGACEHFFFFBDADDBD?@BDDDACA#######################
@8OX
CGGGGCCTTTTGCTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJIJIJHHFFFEEEEEECDCCDDDDDDDDDDDDD5@BCCCCCDDDDDDCCBBDD
@8OY
CTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCCTTTTGCTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCC
+
@@@FFFFDAFDHABHGGFHHCEDHHGEIIIIIIGEFIGIIIFCCCCCC>ACCCCCCCCCACCCCCCCA>CCCCCA?ABB?AC9A@C??<95>BC@:3:C?9
@8OZ
CCCCAGTCGAGGTGGTAAGAGCCCCGAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCCTTTTG
+
C@CFF7=BFH>F1C1BEFC?AFGFED@DGGGE>BDDDBHG<FG@1)5<(+3>CDC3:@(&)0;0?A(8&(090?0(493<A<32+<AC(+)09)&5<>CAA
@8P0
GTTTGGGTCATCCATTTTGTCCCAGTCGAGGTGGTAAGAGCCCCGAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCA
+
==1=DDDAFHHHHIGIJJGIGHGGHHGHFGI:DG@GHIIIGIIIGFGIGIEGIJJFHHHFFDDD@@AAC@CCDCC>C@BDDDBCDCA@?BDBB22@CCCC3
@8P1
CCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAGGAC
+
@CCFFFFDFHHG?HE3BDEHGGGGCGCHGEG0B;BGD>F9FHBDFE@FGIII.;5'9B@>B;AC@;;(,88888:@CCD:??<A?C::ACDD<CACDDBDD
@8P2
CGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAA
+
@CCFFFDDHHHHHJGGJJIIIJJBGGIHH??BEFABEDBB?BDBBDDD9<ACB?C(097<BCCDCCA>;>@BD1<ACCCCCCB?39<:33>A<?#######
@8P3
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTTCTGCAAGGGT
+
CCCFFFFFHGHHHJJJIJIJIIIJJJJJJGFIIIGGGJJFHHGGIJIJJJJHHGFFFDCDDDDDBBDDDDDBDBDCACCDDDDBBDCDDD:@CDCC>C@?<
@8P4
GCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGCGTCTCCGCTTTGCATTCTTCCTCCGCTCCGTGC
+
CC@FFDBDHHHHGJGIIIJGHIDFHGIID3DHIIIJIEFHGG@EEEDECEEEDDD8@BBBDBA######################################
@8P5
TCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAG
+
CCCFFFFFHHHHHIIBG@GIAG)?FGIGBDGIGIIIIGGIIICF6FHBGH<CBDBA>?,:>>CBB?B?@:A@CCCBBBBC@C:CC:A@<@A@B8?CAC@>C
@8P6
CCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCACGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCT
+
1==B7@DDCDBFH?A<AFFHAHH;CFH@G:CFGB@FCCEHHI@F@=@=4))-6=?@D)7/?@>A9(59>88?>CA@;:<?CCCC#################
@8P7
TACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGG
+
@CCFFF8DDHHHHIJJJIIIBEE>FGADCHCIFFHGH?E>FBEHGGGGHEGHGIIJHFAHHFFDF;;>>CEB>=BBDD@CBDBDDB?@::?5?@DBAB<5>
@8P8
CAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTC
+
CCCFFFFFHHHHHIJIIJIIJJGIJJIJJIIGGEDHIJIGGE@GIJJIGHFCCDBDDDD;<B?BDDDDD?BDBDBACDD(9?C<>BBDDDD?099)02>@C
@8P9
CGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGAC
+
CCCFFFFFGHHHHJJIJIJJJJJJJJIIIIJJJBGHIHIGEGHIIGJJJJJIIJJIIFFFDDBDDDDD>A3>CAACCDDBBDDDDDCCDDECCCDD?B@BB
@8PA
CCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTG
+
C@BFFFFFHHHHHJJJJJJJJJJIJJJJJIHHIJJJJJIJIJJJJJJJHHEIIHIIHFCCEDBDDCCDEEDDDDDDDDCDDDDDCDDEDDDDDDBBDDBDD
@8PB
CTGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGACCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTG
+
B@@FFFFFGHHHHJJJJJJIIJIIJJIJIJBFGHIIGGIJIJJGIJIJ<DBGHHHA@EDDCACEC;>ADEDCCC@ABDDD@DDCCDDACCCCDDA7?@BDD
@8PC
CCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCCCACAC
+
CCCFF;DAHHDHDHIIHIGIIJIAHIH@@<EB<?CD=DFDE@FHIJGGHHIJJHIGGHI@CC@;@DE3??AC/?BCCCEB<=;=<2:>9,9?@9<@BBBDD
@8PD
CAGCTCACCTTCAAGGACCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCG
+
???DADDDDDDDDIIE;EFEEI+A<CF?FEEEIIEIIIID*?DDIDDDDDDDDDDD<7?ADD:@A@A????>?AAAAAAEAAAAA<88<>??<<?>????#
@8PE
CCTGGTGTCCTGTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCG
+
@@@DD?DDFHDH<EDFDFGHGHI?FGHIIIIIIIIGIGEH=;CFHGHHHICHHHFE?BDEDEECCCCCB==@BBCCB@?BBB?&0595:A@##########
@8PF
CATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGGCACTCTTCTTTGTCG
+
CCCFFFFFHHHHHJIJIJHIIGJIGFHGIJJIJJJJJIIHIJJJJIJJJJJGHHHHGHFFDACEEEEDDDCCCDEDDDDDDDB##################
@8PG
CCAGAAGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACN
+
@@BFFFFFHHHHHJJJJJJJJJJJJJJIJIJJIIJJJIFHIJJJHGIJJIIJHGHFFFDDDDEDDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDBBBBC#
@8PH
AGTGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGGCGTGCACAACCTC
+
@??DDAED?<FAFI=EHIJGGHEGHH;CDHIB3:?BCBFDFBF9@FF<AG@EEBBBBCC>>@@>3;;?#################################
@8PI
TGCATCCACAGGGACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGA
+
CCCFFFFFHHHHHJJJJJJJJJIJJIJEHIJFHGIIJDGGHIHHGIDIIHHH6?BEFEEDEEEDBBDBDDDDDBD@@<@@DDBDDBDD<BD@CDBDDDDD<
@8PJ
GCCGCTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTC
+
CCCFFFFFHHHHHJIJIJJJJJJJJJIIIJIJJIIGBHHGHFCDFFEDDDDDDD?BBDB@@?CDDDDDBDDDDEECCEEDDDDBBDDDD3<BB9B@B0>@@
@8PK
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTGACTCTTCTGTGTCGGTGGGCGGGC
+
CCCFFFFFHHHHHIIFHHIIGIIJIGCGGGGEIEHIECEGIIGGIIJJJJEGGHFHHHFFBCFEEEDEDDDD#############################
@8PL
CAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGGGGCTCCCCTTTGCATTCTTCCTCCGCC
+
@@@FFFFFHHHHCGEHGHJJJJBHHIIIHIB;FFHIGJJHEHFFEDDBDD?BBDDFCDDDDDBD@DB@8?###############################
@8PM
CTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAG
+
@C@DDDDDFHHDHIJIACCGEFHIIJIIGGIJIIFGCGHIBDGGCG@DFGIIJJJIEHGGBBDDDA>BBDDDBDBBDBBBBBBDABDB?18?>@BDBDB?<
@8PN
CGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGT
+
@C@FFFFFHHGFHHJIFIJJHHIJJJIIGIJBHIIEHGIGIEGIEFFEDCCEC?@BDDB@BBDDDDCDDACCDD<?AA?BBB?7005>BB9<<A>9>@###
@8PO
CGAGGACAACGTGATGAAGATCGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGT
+
@CCFDFFFHHHFFGGGJIIJIIIIJJFHEIIIJJJEHIGIIIGGHEFBBCCEEDD?CC@DDDDDDCCCDCCD?CDACBDDDD@5<@B99BDDBB@######
@8PP
GGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCCCGGTAAGGACACGGTCCAGGTCCTCCACCA
+
CCCFFFFFHGHHGFIJIGIIHIJJJIGIJJGIHHIGGIIIIGB4=/;>>6>>C3555>>@;=8<@####################################
@8PQ
CGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGT
+
CCCFFFFFFFHHHJIBHIGIGGG>HHFHIIIGEHG@F@AHEHHEDFFFEEECEDDDDDDBDBBDBDBBDDDDDB55?@C4>CC@A?355>-<CDB@B####
@8PR
CGCAGACTTCGGGCTGGCCCGGGACGTGCACAACCTCGACTACTACAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGT
+
CCCFFFFFGHHGFIGHGGIIBGIGHIGHGGIJEGGEHGIHAEH@BEDC@@CCCDDDB?<B??@DB5;>BBD?AB>@?B((+:@>CB###############
@8PS
GGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCA
+
CCCDFDFF>FBHFEEHGIG>F;3<FHIIIIIIIE>B?CFGHHIIGCDFGGHGGIIIIII)8CFCHE4).?;=7;?CBD@(6>@=>ABBBC@??@C>58A2<
@8PT
CAGACTTCGGGCTGGCCCGCGACGTGCACAACCTCGACTACTACAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTT
+
CCCFFFFFHHGHHJJJJJJ):?DHFGIDGIJJJJJHHHFFFFEEEECDDDDDDDDDDDDDDDDDDDDDCDDD9BBBC@CDDDCDCD>B@BCCDBDACC>CC
@8PU
GCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTG
+
CC@FFFFFHHFHGJJJJJJJDGHIJCHIJJJJHFFDDCBDDDDDDDDDBDDDDDDDDBBDDABDCDDCCBBD;@BCC@>CDDBDDDBDDDDCC:@CDC?C?
@8PV
CCGGGACGTGCACAACCTCGACTACTACAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTC
+
CC@FFDDDAHDAHIG;GDHGGIIDGI@GGGI@FAHCEG@CBF(5@AE<<<;?;?AB8?@(>+:AC::0(05;@B<<8?@::>@>CCCCA>B>23>C@CACA
@8PW
GGGACGTGCACAACCTCGACTACTACAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCAC
+
BCCDFFDDDFFDHIIJIJIIGJGIIJIIEICB@BFFGIIJJHEH;AEBECDEB:;?BDD5>CCCC8<&&95<99?@@CDDCDD9>CCBBD<ACCCA?:?CD
@8PX
NTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCN
+
#1=DDDFFHFFHGIIEHDFHIGGGIIIIIIIIIGEGIIIGIIIIIEGIHEFDDDDDDDDBDDDCCDDDDDDDDDDACDDDCCA?CCDD?C?CCCCDCB>?#
@8PY
CTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJIIJIJJJJJFGHIJJJJJJJHHHHFFDFEDDD>CDBDDDDDDDDDDDD?CCDCDDDD#
@8PZ
CGTGCACAACCTCGACTACTACAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGA
+
CCCFFFFFGHHHHJJJJJJJIJJJJJJJIJJJIJJJJJIJJGIJGHHFFFADDDC@CCCDDD<@B@D<?C@?B>>:>ACDDDD@BD?C@ACACCCCCB@AA
@8Q0
CCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGAGGCAGAAGGCCCGCCCCACAC
+
@C@FFFFFHHGHHIIIIGIJIIJJHIJJIIIEHIICHHHGIIIIJJJJJIDGGIJIJJJJBHGCHGEGHH2=9?BABCA(5(,,58??BDD89B@>0<9?D
@8Q1
CGGCCGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCG
+
@@@FF<AAFFHGDGEHBFHGIIJJ:C?GGCHGHDHGE>??FCBBGGGHIFIC;FHGCHGDBHHHEB8//09<C?>@<8099-9059??B???A<7>02<C#
@8Q2
GGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAAC
+
+=?DDDFFHHGFDIIIIIIIEE>FDEAHGIIGIIGGIIIIIIGGI?EGIIIIFEFHEGEGIGGCCHH>DEFF@ACC>>AB(5=C?BCCDCA9A>AA#####
@8Q3
CAAGAAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGG
+
C@CFFFDBBHHHHIIGHIGIEIE>@;BGG;FEEE=FHGDHG9ABBDB;ABA@CDC@CCCC:>'30?CD:ACC>CCCA@??B:@>@78@38<::@ACC335<
@8Q4
GTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGC
+
@@CFFFFDHFHHHHIJJIJHJJJJJIIJGIIGIJEHGHGHHFFFDDDDDBDDDDDDBBD@DDDBCDDDDDDABDDB@BDCDDC8<@<<BCCDDDDDD<<<0
@8Q5
CAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTC
+
CCCFFFFFHHGHHIIIJJJJJ@HGGHFHIIHIJEGBHEEECH=?BDD>CE9@CAB=6,5:>CCCCA?9AC@?A(:4>?2<A@DC@C@@C:A9@-0ACCCC>
@8Q6
TTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCCCACACCTCAGCACTCTGGGGGGCAGGATGGCCG
+
CCCFFDFFHHHHHJJHHJIIIJJJJJIIIJJJJJIIJIIJJJGIJJJIJGGGIJJJJJJIIHHHFFDDDDDDDDDBDDDDDDDDDDDB@DDBD>?CDDDDD
@8Q7
CGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGA
+
@?@DDDD?CCDCFE?C?CDHC>DBH@)88D@@9B7;@)=@7@D)7?;:59A>>@@5A;?>CB@(9A,,55(80?B<@:4(:@###################
@8Q8
CGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGCGA
+
@@@FFFDDADFHFI:CFGFCBHDEFFCG@FFHGCH<FF9D=EEG@CAHDB5>>>ACCCC>>BD99<:C@C?<>CBDC::>3443&&)0<>>@>CCA>A###
@8Q9
CTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCN
+
@@@FFFFFHHHGGJJJJJJJJHIIJJIJJJJIIIIJIJIJIJIJJJJIJIHHHHGHHFEDFDDDDDDDDDDDDDDDDDDDDDDEECCCCBDDDDDDDCDD#
@8QA
GCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATC
+
@@1DDDDDHHHFHIGII?FHEEGICEGF:?;?F6D<FB=FH<DFHEGFHHCBECBCCACBC?@@5>5;<<@C<?>>>ACC:?>B<5<>>>:ACACCB?9A:
@8QB
CGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTT
+
CC@FF?DFHHAH=GGAFG<FHHGBHIGIDDHBFHEGBCHHGHIF;BCEG;C@=)7?C?CB@ACEE>==@?19(5,,5:(>=B>BB>CCCDC>3<A?>>A3>
@8QC
GGGCTTTCTGGGGGCTGGGCCTCACTGCAACCAGACTTGGTGTCACCTCCGAACGGGATGAAGTTTGGGTCATCCATTTTGTCCCAGTCGAGGTGGTAAGA
+
CCCFFFFFHHHHHJIJJJJJJJIJJJJIJJJJJJJJJJJJIHHHIJIJJJJHHHFFDCDDDDDDDEDBD@CBCCDDCDEEDDDCCD=CDBBBB0<@9AA@A
@8QD
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTACTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTTACTCTT
+
@@CFDFFF?FFHGJJJFBCGGHIII>)1?)0:@GBEGIHFBEE7=3@G>CGEHGFHBD)7??C@@@(5=>?>;>>(:??A(:CAC################
@8QE
TTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACTCCTGTTCG
+
CCCFFFFFHHHHHJJJJJJJIHEGGIFHHIIJJGIG@HIHIJFDGEIIJJJJJHHHHGFFDFFBCECEDCDDDDD?CDCCCDDDDD###############
@8QF
AAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGG
+
B@CDDFFFHGHAFIGIIJJJJJJIIIJIIIJJGIEGIIGIIIJHIIJJID@GGGEEFHEE;@DFFEEECDBBBDDCCCC:@<A?5CCDDDDDBDD<BB@@5
@8QG
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTGTCGGTGGAGGGCACG
+
CCCFFFFFHHDFHGIBFIEHIIFGAHIIBFDG@HGIIGIECBCHE@FHEHBG6?EHEDDBCF?@CEDEACCCCBC##########################
@8QH
GGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCT
+
@@7BDFDEHHHHHIIIJIJGIGGGHHGIDGGHIGGGEIIHHGEE;@CFDDDDBB?A?8@=@7?>CCABBDDDDDEDDACCCCDCDBDDDBBBB>BB.98>C
@8QI
GTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCT
+
CCCFFFF@HHHFFIFIGEIJJJGIIGIGGHIGIJGC@BFHIIJIDCEIIGEEHCACE>=;;BDDCCDC;@B3:@A::(5,,<5?::::>>1?#########
@8QJ
GGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCC
+
@@CFFFFFGHHHHIIJJIJIHHICDGHBHIDEHGIIIJIIJGHGHIFGHIGGIHAHHHEEFFEFDCDDDDDD:CDAC?@BBC>@CDECDD@9@<@<55><<
@8QK
GCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCCGAGGCTCCCCTTTGCCTTCTTCCTC
+
CCCFFFFFHHGHHGIJHIJJJIJIJJIJIJJJJFID@EGFFEHF=BDDDDDDDCDDDDDEDDDDDDDD<9?##############################
@8QL
CACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTG
+
@@@DDDFDDHHFHJI<CCHHCGGGFGGIGGGGEGGG;C=@@EEHH(7;BDFCEDAA;C?;15=??<@BDB508?CDC09<>?@C3@CC>7???>3:>CCCD
@8QM
CGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTAC
+
CCCFFFFFHHHHHJGHIJIJJJJJEEHIJIJJJJJJGIIJBGHIJJIIJJHHIJIJJIJGEFFFFFEEEEEEDDDCCDDEEDDDDDD@DBDDBADDBD<@@
@8QN
GGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTGACTCTTCTTTGGGGGCGGCACTGGAAGGAAACGGT
+
?@;DDDDDFF?FDFFFFEHIFG9AFFFFGCCEFDF*9;FGIIIIFIIA9FEFF@D8=FEED########################################
@8QO
GCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACC
+
CCCFFFFFHHHHHJIJIJIIGIIJGHIJIJJIJJJIJJJDFGGGHGIJIJIJIJJJJJIHHFFFEFFEEEDEBBCCCCDEDBDDDDDDB@BBB?BBDDDDB
@8QP
GCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACC
+
CCCFFFFDHHHHHHGIIJGGHEH:CFDDGFEG@HGGHHIDGHGIIFGHIIJJGJJIGIG=ADCFFFFEECECD8AC@CDEDDDDDDDD<BBDDBD<<B92<
@8QQ
GGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTC
+
@@CDDDFFHGHHHJJJDGGJJJJJJJJJIIJJHJJJIIJFGGCGGIIAHHGFFFFEEDEEDDD6?BBD<ACABDD@BDBBBBDD9<9>CCDDDDCD<B?BD
@8QR
CTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCC
+
B@@FFFFFHHGHGJJJJJJJJGHGGIIJJJIIJJJJIFDHIJJIJJJFHHIJJJGGIHHEHHFFFFFFECDDDDDCDEDDDDD@DDDDDDDDBDD>BBBCA
@8QS
CTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCC
+
CCCFFF:DFFHHHIJIFGFGIGHCGIIIJJ@D@GI9F9BFFHGHGCGHHDHIG;@4;AAECFFFFFDDEAB:?CD(5>AAA@D:?09&)08@<09<B??>?
@8QT
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGCGTCAACATTCTTTCTAAGGAATAGGAA
+
@@@FFDDD8D1CCE>BEEHIJIB:BGHCCGD*00?FFCB=FDCGGGG@A;6)7=A=?>E=?B>>;CE@#################################
@8QU
CTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGT
+
CCCFFDFFHHHHHJJJJJJJJJIJJIJJJHIJJJJJJJJGHJJJIIJJIJJF3;,55>@::A:@3;(5(5;)8;1:559??5@(8?###############
@8QV
CTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCC
+
CCCFFFFFHHHHHJJIJHJJJHIJJJJJJJGIJJHIJGHIJJIHIJIGGIJJJJJJJHHHHHFFFFFFDEDDDDDDEEDDDDDDDDDDDDDDDDDBDDBDB
@8QW
CTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCN
+
@@CFFDFDHHHHHIIIJIIGHIJGIJJJJJFIJJIIJIJIJJIIIJIIJCGHJJJGGGHGFFFFFFFFECD@CCDDDDD@DBDDDBDDDDDDDDBBBDBD#
@8QX
GGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTATGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCA
+
@@@DD8DDHHAFBB?@FHG+<C9FHH@BF@):?G*:B7BFD???BGIIIIF6F;@D=;AE)7A:@C?>CC>;@@AB9;;88?5@BBA?BBB><(+4<>BB@
@8QY
GTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTG
+
@@@DBDDDHFHFBGEB4CBBEHIIGFD?DCCGCDFHI>FHGHICGIIAGIGGEHGIGIFHHEEEEEEECCCCBBB@@B@<?@BB@9>BBCABBBBBCCBC@
@8QZ
TGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGG
+
@CCFFFFFFHHGHIJIJJJJIHCH9CGIIIIJJIFGGIJEHIIGGIIDHJIJIHJIDHFHHHFFFFFEDDB?B=@9<ABBBDBDBBCDBDDBBDDDD@CCC
@8R0
GCGGGGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGAGGCACGGGAAGGG
+
CCCFFFDDHGGHHGIJJ>GHGIJJJIJIJJIJIJGIIIGGI@GEGIJJGHA?CEEDDBFDDDD######################################
@8R1
CCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTC
+
CCCFFFFFHGFFHJJIGJIIIIGGJJJJGJJIIGIJIJIJEGHIIIICEHFF?C@ACDCDDDDDDCCDDDCBBDBCDDDCACCCDCCDD??CDCCCCCB>>
@8R2
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGT
+
CCCFFFFFHHHGAHJGIBFHIJIIGJJJBGHIJJJFIIJJJJIJJJJJJJJI=ACHHFFFFFCCEDDCCDDDDDD##########################
@8R3
TCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGT
+
CCCFFFFFHHHHHIIGJHIIIJIJIGIIJIIIIJHIIGIJJBHGIIIIEFGDABDBDDDCBBBBDDDCDDCDDBBACCDDDDDCCCCCD@<ACDCD<CAB3
@8R4
CGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGA
+
CCCFDFFFHGHHHJJJJJIJHIJJJJIIJJDHIJJJJJJJEHIJIJIIJJJJJJIIJJIJJJDIHHFFFDDDDDDDBDDDDBDDDDDDDDDDDDDDDDDD8
@8R5
CGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGA
+
CCCFFFFFFHHHHJJJJIIJHGIJGHGHJJDHGIIIJJBHDHHIJJJJJJIGGI>EHGIJJIGIHHFFECDBDDBBDD>BBDDDDDDBDDDDDCCCCDBD@
@8R6
CGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGA
+
=@@DBDD>DFHHD;CFGA@C?FHIGGDICHEHGHGIEGHH@FCGHGGBEDFBCGEAFCGIIIFGEEBD:BBBBAB@<B9@BBCB0599BACBCC@A9C<?8
@8R7
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTT
+
CCCFFFFFHHDHHJJJJIIGGIIJJIGGIFGBGDGDHIGIIIJJIIJJIEIJHHHGHEFFFFFECEDDA>CDDDCDDDCCDDEDCCDDDDB##########
@8R8
ATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGC
+
CCCFFADDHBFFGGEHIIJBJJHIJIJGII@FBAGGIEE9FEIJDGCEFGEED;>FCGD@CHFGC=?>;BBCCCACEED@@AACCCCCB359@ACACD@?B
@8R9
GTACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCC
+
@@@DDDBD>AFFBE?ED@DIGHHGIGG@E@AFGGIGB>HGGEADEEDACABB;@;2?<?BBB<A<7@?+8<5>@<58<<(288?9AB?A?-5)&+:@@9<C
@8RA
GTACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCN
+
@@@DADFBDHFFHIEIGFIIHEH@GIGIIGHGGGDCDHID@BEC@;?A;A?;>?BB@B?7@BD<<@><8A<;B@@BDB?08?BBCC?9ABBB)50:>A9A#
@8RB
TCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTC
+
CCCFFFFFHGHHHJJJGHJJJIJJIJHIJJJJJJJIGIJJJJJJJJJJJJIJJJJJJJJJJHHHFDDDBDDDDDDBDBDDDDDBBDDDDDDDCCBDDDDDC
@8RC
TCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTC
+
CCCFFFFFHHHHHHIIIJJJIHID=GCFGIJIJIJJHGEHIIJIJJIIIIHIJIIGHIIJIHHHFDDDDDDDBDDDD?CDDDB>BCCDDDCDCCB<8<<A:
@8RD
TCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTC
+
CCCFFFFFHHHHHIJJFHIJJJJJJJHJJJJJIJJJEIJJJJJJJIJJJJGIJJJJJJJJJHHHFDDDBDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDD
@8RE
CCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCT
+
C@@FFFFAHDDHHIBGHI>HGHJFCHGIHGGDCFH:GGGHIIGBE<FCGIGCGGGHGE;@DGGH<EHE?DECCEDE@@@CCCDCBCC>@>A9?BDDDBC8<
@8RF
CGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTG
+
CCCFFFFFGHHHHJJJJJJJIJJJJJJJIIIIJGGGIIJIIFHGGIIJIHHGHHFFFFFEEEDEDDDDDDDDDDDBBCDDDDDACDCCDDDACDDDDDD##
@8RG
CTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCT
+
@C@DDEDDHCHDFEHGGJID:CGGCAFGHGEAGGH@FHHJICGGEHHGCBHHAFHEGIJFHHGD>>58??BB@;BB<3<9@@BBDCB>3+494?882<<CC
@8RH
TTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAG
+
CCCFFFFFHHHFHIJJGBEGDCHGIDGGHGCGGHIJJJJEG@FHACFGCFGGGHIIJJHFECEFECCCDBC((;A?=A;@C??C?9A<CCC@CCCCCDDCA
@8RI
CCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGC
+
@C@DFFBDHHHHHJIJGGIIJJGIHIAGFFIBFHGIJIEGEGGEHGIGI<FGFCHHDDBBBBDBDDDBCBD>@99CCDDDCACCDD??+2>CCDDCDACCC
@8RJ
CTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGT
+
CCCFFFFFHHHHHJJGHJJJJJJIJJIJJJIJGIJJJIIJIIEGIGIFIJJJEGIIIGHHHHHFFFFFFEDEEECCBDDDDDDDDDDDDDDDCDDDDC@B>
@8RK
CAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCT
+
@@CFFADEHHHHFIIEHIGGGGAEHFHIIIGDGIIIIGGHEHIIGGIEHIIIFBGBBDDDBD;7;BB3?>B@;B>>A@A4:3:?8??8ACCDC344>4:AC
@8RL
CAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGCTCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCT
+
@C@FDBDFHHHHHIIGHGJJJIEEHFHGIGIJJIJFIGI)?GHIJGIHIIHACGEDDDDDDDDB@DB:ABBDDDDCDDCDC?ABBBBDDDDDCECDDDDDC
@8RM
GTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAG
+
@??DDFDDHFHDFHIJJGHHJEHGGGGIIIJIJJJDBFIIJJIIJGHHIIIDBDDDDDBDDDDDDBBDD>CDDDDDDDDDBBBBBDAACCDCDCC?CCCC@
@8RN
GTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAG
+
B@@DDDDFHHHFHJIJIIIIGFEG@HIHGHGGGGI?FFDGGIGGGGHAHHEDDDBDDDDDBD@@BD;BBB9>ACCCC9@BBDDD@CDDDD:::>ACCCCCC
@8RO
TGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGGCCTCCACC
+
CCCFFFFFHHHHHJJJJJJJJEGIJJJJJJJGIGJJJJJJIJIH'93;;A>CAC>@>>A:>?B'5;(:8&0??9<28?>C:2<?9>((9::<&2<8<B?CA
@8RP
GTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGG
+
@B@DFFDDFHHGHJIJFGIIIJJJIIJJHIGIIGIAHEHGIJJFIJDDDDBBBDBD@BDD7<@B@CCDCC>CC<?@@BABDDDDADCCC>>CCCCDABD@5
@8RQ
GTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGG
+
C@CFFFFFHHHHFGIJDGHIIGHGIJJIGIJIJIIIGGIIJJFIGGDDDDBDB@<BDBCDDBD7BCCBDDCDCCBBBDDBDCCDDCDDDDDDDCDDCBABB
@8RR
CTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGCAGGAGGGCC
+
=@@ADFFDHFF8FECAGHIIHBDHE>FE>;DGFCGGHDEFGGGH885<?BDD8@?BDB0-7;-9ABCC>39@8<<<AACCCCC>@@CCDDD:AC8??B>9?
@8RS
CTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGAC
+
CCCFFFFFHHHHHIEGEGFEIIHGHICGHIGGGFEHGIHHJJIJJGIGHAAFEGEFE/=3;@CCA@<?B>DD999BB?BDDDDBD3?A?CDDD?<BBD@DB
@8RT
GCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTCTG
+
CCCFFFFFFGHHGIHIDHEBGFHIGGIGHJIIIJHGHIIGGIJHHHDFDD>B<?CCDDDD@?@CCDDDED@AA@><B7<<5<<B50598?CCCBDBDD###
@8RU
TGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGCAGGGCCA
+
@@@DDFFFG?FDHFHII<3CCDFEFFGGAFHIIIGGG0@0?DEBDDDBDD57@D?AB/7;<BCDBC:4:ACBDDDBBDA@CAC@CC>?CCA>:(33(0<B8
@8RV
TGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCA
+
CCCFFFFFHHHHHHJJJJJJJJJIJFHCGHIJJJJJJJJJJJIDDDDDDDDBBDDDDDDD;BDDDCCCDD<BD8?AADDDCDDDDDDCDDCDDDBDBBB@?
@8RW
GGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCAC
+
@@@DFFFFFHHHGIJ:CGHIIIJJGIFHIIIIIIJIGIGIGICDBDDBD@DDBD@BBDDDDCDBDDCCCDDDDDDAACDC@ACCCC?C@ACA?A89>@?@D
@8RX
GGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCCTG
+
CCCFFFFDHHGH;GHIJJJIJIJDHGIIIGIFIJIAHIIDHGIHGFCDEEEDDDDDDDDDDDD?@7;@&5(+>AC5<39?>@>:@@A##############
@8RY
CTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCCCTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGA
+
@@@DDDFDFHFDHHEEEGIIDGGIIIIGBGIIIIII:FGG7=D@(;CHEF>DF/9>BDDBDD:A8ADDBDDBABDDDDDBDDEDDDDD75@?B<><@B@##
@8RZ
GCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIJJJJIJJJJJG?HIIIJJJJJIJJJHAHHIJJIDCCEFFHFFFF@CEEDCDDDDCDDDD@C@?<BB@BB9
@8S0
GTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACC
+
BB@FFFFDHDDFHIJIIJIJGIIDHIEIGIIGEGIBHIGIJ1@BDBDDDB&8<ABBDB7B9?BDDCACCD?8<AA>C@CDAC@CAC@CA@@CDDDB@???B
@8S1
GCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGA
+
CCCFFFDFFHHFHFHJJJIIGIJGIHIJGIJGIJIEIIDGIEDGHIHEFBDEEEDDDDDDCCCDCDDDDDDDDDDCDDDDDDDDACADDDCCCD>ACCDDC
@8S2
AGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCC
+
CCCFFFFFHHHHHJJIJJJJJJJJJJIJIJJJJJJIJJIJIJJIEGGGJGHEIJJJAGHEIJJJJIJIEEHHHHH?DFFECCDDDDDDDBDDBB@BCC?BB
@8S3
CACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGGCTCCGCTTTGTGCTGGGAC
+
BCCFFFFFHHHHHJHIFJJJIJJJJJJJJGIJJJJJJBDA4;B/=,7.;@39/;@;;(5@5;@######################################
@8S4
CTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCA
+
CCCFFFFFFHHHHJJJJJJJIJFHIJJJJJJJJJJJIJDDDDDDDDDDDDDDBDDDDDDDDDDDCABD@??@DDCCDCCDDDCCDACDDDA3>BBDDBB><
@8S5
CTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCA
+
@C@FDFFFHHHHHJJIIBHIIJDHHIJGIHJJBGAFEDBD6BBDD@:BDB@BD-<BDCDBDDD><>?7?B?ADDDDD:@CDCCCCCDC38<BDB@?B?<<9
@8S6
TCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAG
+
@@@FFF)@DDBHDHGC@FHCHIGIIJ<C@):C@DBHGIGEF<FHGCAHHFFFFCDDDDDDCCBBBDDDBBA<@BDDBBDC@CD>>CC&)28<BBBDB<9>0
@8S7
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
@@CABFDDCFHHFGJCGEHAFHCGGHFGGBDDFHEIHIFHH@EIIJIIIJIAHFFFEDDDDD'3;8?CCCBBD@BCDCDCC<@1<ACDDDDCD@CACC8?2
@8S8
CTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCA
+
@@@FFFFFDHGHFIIJIJJJIIIJICHIJJIGGIGHIIDDDDDDDB7@B<CBBDDDDCCD>:::9@8<(8<<CCDC@C3:@CCDDDCC?B(09>BDDDBDB
@8S9
GTCCCAGTCGAGGTGGTAAGAGCCCCGAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCCTTTT
+
@@@FFFFFHGHHH@CHEFGGHCGIJIJJIBGEIIJIGEIJJJJJDB0:BDDDCCDDCDDDDDDDDBDDB@BBDDDB?CDDDCCCABDDCCDDBDDDDDDC:
@8SA
CCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGATGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJGIIIJJBHHJJJJJJJHHHHHFFDBBDDDDDDDDDDDDDDBDDDDDDDDDDEDDDDDBDDDDD<88>5@
@8SB
GGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGA
+
@@@DDDD;FFDF?GHGFD:FBHGIDHII>HIFIIBBBBBBB-0:?BCB@BBB8>C?CC@CCCBBBB?8>ACC3@@:@CCCC@C>?A(5-<???B>BB9@<C
@8SC
CGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTTGGACTCTGTCCTGCAAGGGTC
+
CCCFFFFFHHHHHJJJJJJJJFF?FG)?09D@D(..<C88==C==F)==74=1;8B'.59@?6;55:::5505@###########################
@8SD
TCCTCCTCCACCTCCTGCGGGGCCTTTTGCTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGCCCTCTCTCCCAGTCTCCTTGGTGGGGGTGC
+
CCCFFFFFHHHHGJJHGEGHIIIJIIGECHGIIIIH)@CDHFGHHCHFFDFD@CCACBBB?<@DD?BBDD&59?AC>>CDD?CCCCCDA>@C>@BD<@###
@8SE
CGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTC
+
BCCFFFFFHHHHHIJJJJJIIIIJJJJJJJJJJJJJEHJIJJJIJJJJIHHFDDDDDDDDDDDDDDDDDBBDDDBBBDCDDDDDDDDDDDDBABDDB9>8>
@8SF
CGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCA
+
@@@DDDDDH1CFF?FAFGGHDFGIIACDGHBGHDH@ADEEAFG8(;;AE<B;@C@C6?BBB>@9>A:@??BBCCACAC@A@<CCBB+9?CCC>>AB>9?@>
@8SG
CTGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCA
+
@C@FFFFFHHHHHJJJJJJJJJJDDDDDDDDBDDDDDDDCDDDDDDDCDDDDDBDDDDDDDEDDCDDDDDDDDDDDDDDDBDDDDDDDBCDDDBDDDDDDD
@8SH
TGGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAA
+
@@@DFD6DFHHHHGIIIIGE@C8@BBBBBBCCBBCBB6B6BCCBCCCCC@AB2?BBCCCCDCCACCA>>@CCA?A>9BBBB?9<@5<<>@@?88@<<B###
@8SI
GGGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAAC
+
CCCFFDFFHHHHHJJJJIJJJDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDDDDDDDDDDDDDDDDDDDBDBDD
@8SJ
GCGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCG
+
@@;DDFFFDCDHFIIJGJJIGIJJI8FAA@DAEGHHHHFDA?ADDDDBDDDCDD@?CCB;?BB?@8<BBBBD<AA>+9BDDDCACAA@DCCCC>3<BBBD5
@8SK
GGAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACT
+
@@CFDFFEHHFHFJJJJGGGDDDDDDDDDDDDDD-&07:CCDDCCDDCBBBDD@CCDCEDDDDDDDCACCABBDDDDBDDDD9BB?ACC@?BBBDDDBBD9
@8SL
CGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTC
+
CCCFFFFFHHHHHGGIJJIJIJJJJJHHIIIIDIHIBFCHGGHIIIJCHHHF<BBDDDCDD?BB8@DBBBBDDDD@@CC>ACDCCDBBDDDBB89>@<B8?
@8SM
CAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGGTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTT
+
@@@DFFDDHHHHHJIJCDGHGIJIIFJIJ4;-.)=.7.?).)77;;;3;6@A3(((5(-5>:?(9<?(;@ACC305)0<9<AA:>C?##############
@8SN
GAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTG
+
CCCFFFFFHHHHHJJJJIJDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDBDDDDDEDDDDDDDDCCCDDDBDDDDDDDDDDDDCDDDDDDDDDDBBDD?
@8SO
CCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTGACTCTTCTCTGTCGGTGGGCG
+
@@@DDDDDHFHFHI@FHI?FCHGGGIIIIDHIIIIIEGGGIIGIIFIIDAGIHHHHEEEEEECACCCCC:@BBBBB#########################
@8SP
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
C@@FFFFFHGHHHJJJJJIIJGE=D:F@GBDFCD:@:@G9C=FG@@@@C;C<8C;BD>A=?::88<>@CC3;-9?3@?:>3:<(88>3(+4:43>9>A0?#
@8SQ
GAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTG
+
CCCFFFFFHHHHHJJJJJJDDDDDDDDBDDDDDDDCDDDDDDDCDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDD?BDDDDDDDDDDCDDBDDDDDDDDDC
@8SR
GGCCTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCG
+
@CCFFDFFHFFHHJJJJJIJIJJJCHIJJGIJFHIIIIIJJIJ)/---,9ACBCCCDDDDBBBDBAD<>B>@@CC4@CDDDB>BDDD<?(9<@@B######
@8SS
TATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTC
+
CCCFFFFFHHHHHJIJJIGHHJIGH?DHGIEGIJIGGIJIIIJIIII<GGIHHEBEFCDDD@CCDDDDDDDCCDDC<A?A?BCCDDDDDDAACC@B19AC@
@8ST
CCGCGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGGAACTAAG
+
CCCFFFFFFHHHHJJIJJJJJDGEGIIFGHCFHGGGIFIJJGIJJCEHFHHEFF?D@CCDCCEDDDDD&553(>>>@::>@:(++4:A@CC@@C((8AC@@
@8SU
GAGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTG
+
CCCFFFFFHHHHHIJJJJJDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDBDDDDDDDEDDDDDDDDDDDDDDDDDDDDDBDBDDDDDDBB?B?<BB@BDCC
@8SV
AGATCTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGC
+
CCCFFFFFHHHHHJJJIJDDDDDDDBBDDDDDBDDDDDDDDDDDDDDDDDDDDDDDECCCDDDDDDDCDDBB@BB?BBDDDDDD@CCDDDD@BDDDDDDD:
@8SW
CAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGG
+
?1?=DDD1DDDDDIID3@F:EEEIIIIIIIADDIIIIIIIDAE@EDIIIIIDD?=DD@@?????AA??A?AAAAAA??>??>>???A>><>????<?>?>;
@8SX
CTTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACAC
+
CCCFFFFFHHHHHJDDDDDDCD@DDDDDBDBDDDDDCDDDDDDDDDBDDDDCDCCCDDDDDCDCDDBDDBBDDDD<@BBDCCCB?8?BDDDBBB?CDCDC?
@8SY
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJIHIJJJIJHHIJJJIJJJIGIIJJGIJHHHHHFFFFFFEEEDDACDDDDDDDDDDDDECCDDDDDB-95&2>>@:>
@8SZ
CAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCATGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGG
+
CCCFFFDDFHHHHJJJJJFGEFHIAGHIIGGHHBHIIJJJJJJJI<FHIHHAEHHHGHFFFCCDB;;B<BDDDDDDDDDABCDBD?BBDAB<ABDDDB???
@8T0
TCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTG
+
CCCFFFFFHHHGHJJ;@FHGGIGHIIIGGGH<FDDHGGHIEGHJJ;D;CGEHF@:AD?>CECEEEEBCCDCDC;@@DDDB&593:@:@(>@@A:>:@####
@8T1
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJHHHHHFFFFFFEEEDDBDDDDDDDDDCDDDEDDDDDDD@##########
@8T2
TTCACGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACA
+
@CCFFFFFF>BFDDDBBBDDBB1B?CABDDBBDDDDDCAC@BDDDDBCCDCD>CDCCCDDDCDDDD>BB?BBDDBB<?BACD1<B?BDDD9<?>9CCC@B?
@8T3
CGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGAC
+
CCCFFFFDFBDDDDDDDDDD?DDDDDDDDDDDDDCCDDDDDDBDDDDEDDDDDDDDDCCCDA@DDDDDDDD;BB@CCDDDDDDBDDDDBAACCDDDBDDBD
@8T4
CGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGAC
+
CCCFFFFFHDDDDDDDD@BDDDDDDDDDDDDDDCCDCDD?BDDDDDDEDDDDDDDDDDDCBDDDDDDDDDDDDDBDDDDDBDDDDDDDDDCCDDDDDDDDD
@8T5
CGTTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGAC
+
@@1BDDFFGDDDDDD@BBBDDDBDDDDDDDDDCDCDCDD?BDDDDDDECCDDDDDDAC@><A;B@BBDDDDBDDBDCC?<ABBDDDDBDDCCDDDBBBDBD
@8T6
CGCTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACCCGAC
+
@@@DDDD8FBBB@BBB6)0<B8<367&68ABCAC@88<?<8<?C>8@@@CCCCCCC:@A?<BBBBBBB<;BBB?<@@CABB?<<B9B<BC9CA:3820<<5
@8T7
TTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGT
+
CC@FFFFDFF?FHG<BBEFGIIFIBDH?CD@GEDGHIIIIBHGIIIIDI@CFH<A(@==;AEEEBFFFFBCCC=>ACACC?C?AACCDDDCCA9@3:ACDC
@8T8
ACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGG
+
CCCFFFFFHHHGHIFHIIJIJGIIIIJIJJIGIIJJIIJHHHFFFDCDBDBDDDDDDECDDCD<BD@DDDA<9;955+34:>5<0-<::(4>@A@######
@8T9
CTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGGCGTCACGGTAAGGACACGGTC
+
CCCFFFFFHHHHHJIJIJJJJJIJJJGIJJIIJJEHIJJJJJJJFGIJJJJJJJJHD'83:5>5>:A##################################
@8TA
CTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCT
+
CBCFFFFDDDDDDDDDDDDDDDDCDDDDDDDDDDDDB@BDDDDDDEDDDDDDDDDDDDDDDDDDDDDBDDDDDACCBDADBDDDDD?DDDDDDDDDDDDBD
@8TB
CTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCT
+
?@?DDDFDBBDDDDDB@DDD@7@9BDDDDDDDDDDDD<?ABDDDDD@C@CACDDC>@CB?BBBDBD1530&2<3>:?1(<A@3<5>B39@CCC?#######
@8TC
CTGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCT
+
CCCFFFFDDDDDDDDDDDBDDDDDDDDDDDC@CDCDDDDBBDDCDDA@CCCCDDCDDCDDDDDDBDDDDDDDBCDABDDBDBDBDDDDDDDCCBBDDDDD9
@8TD
CAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCC
+
CCCFFFFFGHHADHEGIJJJHJJJIJJIIEHIJJJJIDGHHHGJJ@FHIIHGCEEHHCDCDFD>CACCECCCDDD>CC@A@ABCD@<@@B&5??A>BB?@>
@8TE
TGGGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTG
+
CCCFFFDDDDDDDD@8BDDDDDDDDDDDDDDDDDDDBDDDDDDDEDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDDDDDDCDDDDDDDDD
@8TF
TGTGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTG
+
@@=DADDDDHHHFI1EGEHGHIIIIGHIIIGII>GCGIGGIHGIIEHFEHEBEEBBCACCBB?B<???BBBBC3>?@B<?@BBBBBCCCCC@BBBBB<953
@8TG
GGGGGCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTA
+
CCCFFFFFHGHFDHHJJJEIGGIJJJIIIIJIJJJIJIJJJJAEGFGHHHFFFFFCDCDDBDDDDDBBDDCCDBBDBBBDDDDDDDDDCCDDBBBDDDDDC
@8TH
CTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGTCCTCTTCTTTGTTGGTGG
+
CCCFFFFFHHHHHJHIJJJGJGIIJIIIJJJJJIIIGIIIJIIIIIJIIIJEEHHH?@DFFEDCEDCCDDEDCCD?BD#######################
@8TI
GCTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATG
+
@@@DDFFD@DH;FHIIIBIGGGHIIIIFHI?H?FHIDHIGIBAFCGH@EGHIEF:?D7?69/9;?BCCA?9?02-05>0<>?CCCCB?95)599C@>C>:>
@8TJ
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGT
+
CCCFFFFFHHFHHJJGIGHIIJIIIJJJHIIIJJJJJJJIIJJIJJIIIJJJEHHHHFFFFFDEDEEEEDDDDDD##########################
@8TK
CCGAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCCTTTTGCTGCCTCACTGCTGCTTTCCTCA
+
CCCFFDFFHHHHGHGJJJIJDD<BDDCDDDDCCDCC:DBBBDDCDDD8BBDDDDDDDD?CB@DDCCDDDDDBBDDACC@CCABDCCBCDCCCDD<CCDDDD
@8TL
GGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGGGGGCGTCACGGTAAGGACA
+
CC@FFFFFHHHHHJJGHIJIIIIIIIJJGIIGIIJGGIIBFHIJJIJJJFGIIIGIGGGIEB380:@@(44>4:@:::35<&0<&5909&2992<?AC###
@8TM
CGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCCTGCGGAGTCTCCGCTTTGTGC
+
@@@DDADDFHFHHIII;FHDH@GHIIIIIIIIIIIFHIIIEFHHE('9<',5>(;@;??;?@AADC<:AC:+40>@B@#######################
@8TN
CGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGC
+
@CCFFFDDHHGHHGGHIJJJIJIJJJJIIIIGIIIGIIJJJJJIG1AD<AA=ACDDDDDBDDC;AC>>C:@CC>@BDDD<AB>@B-<8>>C@-9<B@@CC<
@8TO
CTCCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGA
+
CCCFFFFFHHHHHJJIJJJJJJIIIHIIJIJJJIJJIJJJIJJIJJJIIJJJHHFFFDEDDDDDDCDDBDDDDDDDDDDDDDDDCDBDDDDBBC@CDCDDC
@8TP
CCCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATC
+
B@CFFFDFHHHHHIJJJJJIJHIJHIJAHHIJJJJJJIIFHGGIJJIIIJIHGHFFFFD@BDDC@AA<<8A@BDB>BCCCCCDDDDDDD@BCCCDEDACD:
@8TQ
TTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTC
+
=BBDDDFFHDHHGIGGGIIIIIIFGIFHJIGIJIIGECGIJIIFI99DFGGIGIJIJ<AEHFDDDDDACACDCCCCADDDDDBDDD(:@@+:@@C9<CACC
@8TR
GCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTC
+
CC<DFFFFHHHHHIIJJJIGJIJJJIIJIJFHGHIIIJJHHGGHHFFFDDDDD@BBBBB=B2>ACCDBBBD>ADCACADCCD@>BBBBDD?B>5>0<8AAC
@8TS
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCA
+
CCCFFFFFHHHHHJJJJJJJIJJJJJEIIIJJJJJJIJIJIJJJJJJJJJJHHHHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCCDDDDDD
@8TT
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCA
+
CCCFFFFFHHHHHJJIJJJJGJJJJJIJIJIIJIJJIJIEGIGAHIJJJJJHHFHFFDDDDDDDDDDDBBDDDBDBDDCDDDDBDDDDDDDDDDEEDDCDA
@8TU
GCCCAGTCGAGGTGGTAAGAGCCCCGAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCCTTTTG
+
CC@FFFDDHHHG@GH8ABFHGGIIJGGGGGIEGIIIJDIIJIID@07?CDDCDDDDDDCDDBB@DDC+889>>@BBDDD?ADCDBBACDCDD>BBBBCD<>
@8TV
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCA
+
@@CFFFFFHHHGHIJJJJJIHIJIJJEGIIGIIIIFIGEGHIJIIJFEHIIGHDHFFDCCDDCCCDDDBB@DDDD?CCDDDDDDDB@BDDDCDDDEDDCDC
@8TW
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCA
+
@CCFFFFFHHHHGIJJJIIJGIJIIIGIJJIIJJJIGGIJJGIIJGBGIGIGGHHDFDDDDDDDDDD<BDDD@DD?CCDDDCBDDDDDBDC@ACEECCCDC
@8TX
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTGTCGGTGGACGTCACG
+
CCCFFFFFHHHHHHIDIIJGHIGIIJJGGIIGIGIHGGHHHJJJ>GIHEHIJAEHHHFFEFFFEEDDCCCDBDDB955:>CCCC>(:35>5(58A<5<8?9
@8TY
CCCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCA
+
@CCFDDFFDH<CC@GGCFHI?FCAGH;??BFEGGHGIJGC@CGAGHHFGGGFEFH?BB6<BACC;=A9?ABDDBB?C>CCC38?BBB@>>?>@AC3>:AC@
@8TZ
GTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGG
+
CCCFFFFFHHGDHIJBHGIFHHIJJJJIFHIHGIIJJGGGIGJIJHIIIJJIIJJEIGGHIGH:=@BCDCDDDDD<@BD0<@BDDDDDB?BDDDDDDDDBA
@8U0
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGT
+
CCCFFFFFHHHHHJJIJIJJJJJJJJIHGHIGIJJGIIIIGGHGGCHJIJJJAEHHHFFFFF?AEEEECDDDDDB##########################
@8U1
CCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCAT
+
@CCFFFFFHHHHGJJJIIJIJIJIIIJIIJJJIJJIJGEGIIGIGHGIJFHJGGHFFDDDEDDDDDDBBDDDBDDDDDDDCDDBDBDDDDCCCEACCCDED
@8U2
GGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCT
+
1:BDDFFFHHHHHJJIJIIJJIJJJJJIJJJIJIIIGIIHHHHHHFFFEDDDDDDBDDB@5<@94@C@@BDD>:>>CACD4@C@9<?BBD&2299>9B8>:
@8U3
CCGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCGCGCCAACTGCACACACGACCTGTACATGATCAT
+
@@@DFFDDH<FDHJIGIGIECDFHEBHGICHIEEG4<**?FDFHICCG>BGE=;=<?BDC@CCCBD?(3;9@BDDCCC:>4??BD@BBBD@C>@C@>CDD@
@8U4
CGTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATG
+
CCCFFFFFGHHHHIJJJJIJJGJIGIJJIIIHJJIJIIJEGIJHIIGIJJJGHHHFFDCEEDDDBBBBDBD@BDDDCCDCDDB@BBDDDCDDEEDDDDECC
@8U5
GTACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGC
+
@BCFFFFFHHHHHJJJJIJJJJJHJJJJJJJIGIIJJJJJJJJJJJJIJJJJHHFFFDEEEEDDDDDDDDDBDDDDDDDDDDDDDDDDDDDEEDDDDEDDD
@8U6
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTN
+
CCCFFFFFHDHHHIGIJJIJJJJJIJIJGIIGIJIJJIJJJIHIJGHJJGIGFGGBDFFFFEEDEECDDD;?CCCDCDDDDCDDEDDDDDDB#########
@8U7
ACCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGG
+
@C@FFFDDFHHHHJIFBGGIICHGIIJJI>DGGHJGIIGHIJFIIIIIIIDEHEBFFCEECC@?BDDDDDDCDCDCDDBDD<BD@CCC@BCCCDCDDDCDB
@8U8
TCCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGT
+
CCCFFFFFHHGHHJJIGIIJJHIIIGJJJIJJJJHIJJJJJJJIIJJIJJJHHHFHFFFDEDEDDEEDCCCDDCCCDDDD@####################
@8U9
CGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCA
+
@<<DDDDDFHHAD@@FGHIII>DGCGIEFDEGGFEGGHBCHGIAGGGEA/=(;@;A>B@??C@CCAACB?28ACCCCCC<CA@CB??ACCCC@:@B9?CC>
@8UA
CCCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACTCACGACCTGTACATGATCATGCGGG
+
CCCFFFFFHHHHHJJJJIJJGIJJIJJJJJIJIJJJJJJJJJJJJJJJJIJHHHFFFFFDECDDDDDDDDDDCDDDDDDDDDDDDDDDEEDDDDEDCCBD@
@8UB
CTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAG
+
@@@DDADDFHDFDGGIH>FEHGIIIG7@@FGDIIGHEBB>B8;??=<AB<9?8@8?C57B@BAA1<@BBBCC83?8-5&5?C(:?3>5<>&55<C94+::A
@8UC
TTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGA
+
CCCFFFFFHHHHHHJIJJIJIJJJJJJJJJIHJJIJJJJGJJJJJJJJJIJHHHHDEFFFFEEEDCCDDEDDDDDDDD)9):4>:A@C>@CD>:49@5<@#
@8UD
TCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCCCT
+
@C@FFFFFHHHGHIJGIIIJJIIIHEHIGDBHEGEIDGGIIIJIIIJJJHGFEHDFFFFEEEDEECCDCBB<CCCCDCCDDDDDCDDDDDDDB########
@8UE
GTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCT
+
CCCFFFFFHFHHHJJHIJJJJIJJJJJJJIJJHJIJJJJJJJ:BEFFFDCDDDDDDDDDDBDDDDDDDDDDDDDDBBDDDBBDDDDDCDCCBDDBBDDDDC
@8UF
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTAAGGGATAGG
+
CCCFFFFFGHHHHJJJJJJJJJIJJJJIGGGIIIJGJJGIJGGIJJJIJJIJ?EHGGFFDFFEEEEEEEDDDDDD-90&8>@@>A################
@8UG
CGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAA
+
BCBDFFFFHHHGHIIJJJIGIJIIIGGIJIIBHHCEGIIHBGHGHHFFFFFFFFEDDDDDDDB@BBD7BBCACDBB9@DDCCCCCC?<ABDC<4@CCCAA@
@8UH
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGGGTCTCTTCTCTGTTGGTGGGCGN
+
????A??DD?C?C?@):1?BD??DDADEI@DBDECBB=BCB==7AC>@AADD6=?C:777A2?>@AD>AA=;?############################
@8UI
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHHHHIJJIIJGIIJJIJJIJJJJJJIJJJJJJJIJJJJJJJJJHHH>EDFFFDDDDDDDDDDDDDDABDDDDDDDCDDEBCCCDEDDCD9@#
@8UJ
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFGHHHHHIJEEH@EGHIIIJGIHIHJJIICHIJIJGIIJJJJIJIGHHCHFFFFDDDDDDBDDDCCCDABDB5@B9?CCDDEDADDEDC>B###
@8UK
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHHHHGIJJJJIJJJJJJJJJJIJJIJJJJJJJJJJJJIIJJJJHHHHHFFFFDDDDDDDDDDDDDDBDDDDDDDDDDDDEDDDDEDDDDDD5
@8UL
GTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCACGGGAAG
+
@?@DDFFFAACDHGGDGHBCDCGIIIIEHGHIEEGIIEIEIII?=CEHIEHIIIGIGGGHEHHCBB###################################
@8UM
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
@C@FFFFFBDDFHEHIGGI=GHGJJJCHGHEDHIJJGG@EFCHGGGDHGGGEAEECAB?@D??BBBBDDCCCCCDDDB@>>B>?CCCDDC>@@ACCCDB@>
@8UN
CCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCT
+
CCCFFFFFGHHHHJJIJJJJJJJGIJGHJIBFDHG:FCEHGEEEEFFDFDDDEEEDEDCDDDBDDD<B>@B9B<C@CC>BBDDDACDDCDDABBCDDDDCC
@8UO
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHHHHIJJJJJIJJJJJJJIJJJJJJJJJIIJGGJJJIJJIJJJHHHHHFFFFDDDDDDDDDDDDDDDDDD@BDDDDDDEECDDDEDDDDDB>
@8UP
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHHHHJJJJJIFHEHIJIJJIJJJIIJJJJJJIJJJJJIJIHJJHHHHHFFFFDCDDBDDDDCDDDDDDDDDDDDDDCDDEDDDCEDDCDDD9
@8UQ
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHGHGHIIJIGIIJJJIIICHGIIJJIIEGHGHIIJIIIJJJJIHGFEECDDECDDDDDDDDDDDDAABDBBDDBCCCCEBC(>ACDDDB953
@8UR
CCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTAACTCTTTNCGGTGGGCGTAC
+
@C@ADDADHHH@HBEGHF6?FGIGIBGGIEBFGIIG=FHGHAHGA@DGG;C;C=?@@DFFCEC?6>C:;;@>?1=5@########################
@8US
TCTGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGGA
+
@B1DDFFFGDHHHJIJGIIJJJGIGCBBDHIGHIGIIJJJGIIBDHACHIJGIJHHHFEHFFFFFF:AC7?BBB950:>:@AC:::>CCCCACC#######
@8UT
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCNCATGGATAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHGHHIJJGGIHHJJFHHIIIIJJIJJJIIFGICGIGIGJH#-;DGHH.7?EE@DDDDDDDDCC@C@B@B99@DBCACDEDCDDDEDCCD5@5
@8UU
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
C@CFFFDDHFHHGJHCCEFC=GHEIIJCEGI>DAHGDGHIDGGE@GGIGEIJHHGEHF;??ACDDB8=BDDCDCCDDDBBDDBCA3>CACDDD@AC#####
@8UV
CCCGGGATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
@CCBF)<DFFFDFHGIEGIBHHHIJGFBDFGIJGGIJFIFGIIIIICGHII@EEHDFF<@=ACDD;?B??CCDDC<@BBBBDD<C@CE@CCCCDDCC<B##
@8UW
CGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTC
+
CCCFFFFFHHGHHIJJJIJJJEGHGGFHBFEIIBHGIIBHCEHJIJJJIIEEHFFFDDDD8>B@8ACCCBD;BDCCDCC@CB?BBDDDCCDDCD3A@BD<?
@8UX
CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGA
+
CCCFFFFFHHHHHIJJIJJIJJJJJJJJJJJJIJJJJIJJIJJJJDIJJJJJHHHHHFFFFDDDDDDDDDCDDDDA@DDDDDDDCDDEDDDDDEDDDDB><
@8UY
CTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGG
+
CCCFFDFFHHHHHIJJJJJJJJJHGIJJJJJJJJJIJJJJJJJJJJJHHIJJJJJJHHHGHFDFFFDDDD0953>>@C@C>A3::::5<089(+005<@9B
@8UZ
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CC@FFFFFHHHHHIIIJJIGIJIJJJIJGIJJJGIEHHDGGEGHIIIJJJJIJHGHHGFFFECDDDDDDDCDDDDBDDDDDDDDDDEEDAACDDD39<999
@8V0
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
@@@FFFFDDHFHFIIIIJGIJDGHGHIIGGEHIJIECGGGGIGGJJGGEGIGGHHEHFDFDBDD>>@BCCC@>>A?@DBBD<?CDCDD@A>ADDA######
@8V1
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGT
+
CC<DFFFFHHHHGJJIJGHGJJJJJJJIIIJJJJJIJJJJJIJIJJJJJJJIEFHGHFFFFFDCEEECCCDBDDD9<)(:@@AAC################
@8V2
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJJJJHIJJJJJJJJIJJIJJJJJJJJIJJJJIIJJJJJJHHHHHFFFFDDDDDDDDDDDDDBBBBDDDDCCDEEDDDDEDDA@B@B>
@8V3
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFDFFFHHHHHJJJJIHIJJJJJJJJJJJJIJJJJJIIJJJIHJJJJJGJGHHGHHFF?DDDDDDDDDDDDDD?BD<BDDCACCEDDDDDEDDABD@<<
@8V4
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHIJJJJJJJJIJJJJJIIJIJJJJJJJIGGIJJJJJJJGHJHEHHHFFFFDCD8@DDDDACDBDBDBBD<3::A3:ACDCDDCC@####
@8V5
GGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAG
+
CCCFFDFDHHHHHJJJIIIJJIIIIJJJJHIJJJIIJHHGFFFDDDEDDCDDDCABB=@DDDDDDDDDDB@@BDD>CCACDD<CCCCCDCB@BABD?<>@5
@8V6
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHFJJIJJIJJJJJJIJJIJJJJJJJIJJJJIJJJIJJJIJJJHHHHHFFFECDDDDDDDDDDDD?BDDDDDDCDDEEDDDDEDDCD>BDD
@8V7
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
B@CFFFFFHHHGHIJJIJGHIIIIJJEHJIJJJIIJGIIJJJGIIGIJJJJDGHGHHHFFFFCDDDDDDDDDDDD<>BDDDBDCCDDDDDDDDDDCB@B9>
@8V8
GGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCT
+
CCCFFFFFHHHHHJJIJJJJJJIJJJJJJJJHIJJJJJIHHHHHHFFFFDDDDDDBDDDDDD@CCDDDDDDDDDDDDDEEDDDDBDDBDDDABDBD9>8?>
@8V9
GCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCT
+
CCCFFFFFHHGHHJJJJJJJJJJIHGJEIIJJJJJJJJJJJJIJJIJJJIJJJHHHHHGFFFFFDD@CDDDDDCCDCACDDDDDDDDDB############
@8VA
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJIIJJIJJJJJJJIJIJJJJJIIJIGGHIJJIIJJIIJJJHHHHHFFFFDDDDDDDCDCCCDBDBDDD@CCCDEEDDDDEDCCBBBBB
@8VB
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJIIJJJJJJJJJJJJJJJJIJJJJHHHHHFFFFDDDDDDDDDDDDD?BDDDDDDDDDEECCDDEDCCDDDDB
@8VC
CAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCT
+
CCCFFFFFHHHHHIJJJJJJIIIJJIJJIJJJJJJJJJJHHHFFFDDDDDDDDDDFDDDDDDDDBDDDBBDDDDDDCCCDDDBDDDDEDEDEDACDD>BD?
@8VD
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJIJJIIJJIJJJJJGIJJIJJJIIIJJIGIIJIJJJJJJHHHHGFFFFDDBDDBDDDDDDDDDDDDDDDDDDEEDDDDEDCDDDDCD
@8VE
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
@C@FADADFF?HHHHIDF?FCHGHDEHGIHGGGIIBH<CGEHIGCGGIIBE8;?HCHH?BBF?BB@B@?,>CCCC@B9<BB93:AC@@>>C>CAACB<<59
@8VF
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTACACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJIJJGJJIJJJJJJJJJIJJJJJIJGIIJJIJJIIJJJJHHHHHFFFFDDDDDDD3>CDDDDDDDBDDDDDDEEDDDDEDDDBDDDB
@8VG
GTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGAT
+
CCCFFFFFGGHGHIHIJHIJJJ?FDGGEHIJIJGFFFDDBBBDDDDDBBB<8ABDD@BDDDB?BBBCD@DCA@@058ACC?CCBB9@>@B?CDDCCCCDA?
@8VH
CCAGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
@C@FFFFFFFHHHIJIJGIJHIIGIIIGGGEHGIDHBIIIIIIJGGGHDEEHHGFHFFFDBDDDD<CCDDDDDDDCCDCDDDB?BBDD>CCCDDDDDCDB8
@8VI
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHIJIJIIIJJJJJJIJJJJJIJJJIIJDGIJIJJJJJJIIGHGHHHFFFFDDDDDDDDDDDDDDDDDDDDCCCCDDDDDDEDDDDDBBD
@8VJ
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGGCTCAGAGGCGGGTGGGACTCTTCTTGCTCATGGAAATG
+
@@@DDDDDHDFBD@:<?GHIHHGHEGHHGGI4?FE8BB=B8CGHIAHHGGEHCEEHABDD:B'9A=>?#################################
@8VK
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJJJJIIJJJJJJJJIJJJJJJJJJJGIJJIJJJIJJIJJHFHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEDDDDEDDDDDDBD
@8VL
GGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGTGTCTCCCCCTTGGATTCTTCCTCCGCTCC
+
?@@DDFFDHFDDHIIIGGGIGGHIGHEH@CFG@HIGGHCHEFBBECCCB@BCCFCCCCCB@BBBBBBB#################################
@8VM
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJJJJIJJJJJJJIJJJJJJJIJJJIJJJJIJJJJJJJJJHHHHHFFFFDDDBDBCDDDDDDDDDDDDDDDDDEDCDDCDDDDDDB9B
@8VN
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJIJIIJJJJJJJIIJIJ:CGIJJJJIJJJJJJJJJJJJJHGHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEDDDC(4>CDDDDD
@8VO
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHIJHIJJJJJJJJJJIIIJJIIIIJJJJJIJJJJJJJJJJJHHHHHDFFFDCDDBDDDDCDDDBDDDDDDCCDDDDDDDDEDDABBBDB
@8VP
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
?@+=ADDDHFFHFGI>FHIICFHIII>GI>GGGBGIEIIGIGGGGCEEHGGGGHAECHEBDDABBBBBCCCCCCBBBBBBBBCCCCEEC@CCCCCC9@B@>
@8VQ
GTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTT
+
@CCFFFFEHHHHGIGIIJIHIGIJIGIIGHIIIIJEHHGFFDDDBDDDDDDDDDDB?BCBDDDDDD@BBDBACCD?CBD<><BDDCDDDDDBBDDDDCDDD
@8VR
CGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAG
+
@@7DDDDD<DDDFA8+:EAFFFBFF9BBFF9DF>GD@:?DE@C<FEEFFD>5>>>A;@;?B>@55@>A?@BBBBA4>>:@3:>?B+3<A::>>A@>A<@BB
@8VS
GCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGTCACGGTAAGGA
+
CCCFFFDFHHHHHJJJJHJJJJJJIJJJIIIJIIIJJHIJJGHJIJJIJJJIHIJJJIIJIHDD#####################################
@8VT
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHGGJJJJIJJJJJJJJJHIIIIGIIJIIGIGIJIIJJJJJGHHGGHHFFFFDDDBDDDDDDDDDBDBDDDDDDDDEEDDCDDDDDDBD><
@8VU
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHIIJJJIJIJJJJIIJJJJJJJIEEHIIIIIIIIHIIJJJIGEEHHFFFFDDDDDDDDDDDDDBDDDDBDDDDDEEDDDDECCCDDDBD
@8VV
GCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGG
+
@C@DDFBDFHHFHIIIGHGGIGGIHEGGHI;?FG68BEGGAF@FGIIBE>EEBCDCDCCDCDDDDDCCDCACC>CBD<CDCCDDACB39?CCCCABDBDD9
@8VW
GCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGCCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJIJJIGFGIJIJ@FHIHIGHHFFEFFFEDDEDDDDDDDDDBDDDDDD@CDDDDDDDBCCDDDDCCDDDD@#
@8VX
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFDFHGHHGEHGGIIIIGJIFIIJFIJIJIGGI;FGGGGHIEHIHGIDC?CEFFFFBCB;@BCDCDDDB?BDDDDDDA@CECACCDCCDC9@BBD
@8VY
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCCGGGGGCGG
+
@@@DDDBDF:FF@GEBBBEFGF6DFFIFBF@*?8;BFFEIFFFCFDCCEEIF6ACCED@DDD>;@B@@>@BB@BB##########################
@8VZ
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CC@FFFFFGHHFDFHGIIHGIJGHI@EIHIGIIJIIJJIGGGGIIGHFHGIBHHEHHFD=BDDDDDD@DCDCCDD?@BBBDDDCCCDCCDDDEDCDDB9@9
@8W0
TTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGTGCTTGTTTGT
+
;<=+2?2A,?=@>2<1??733<7AAA<AA=AAA7=84:;9)97=AAA;A2>;>AAA)7>9;><7@####################################
@8W1
CTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACT
+
CCCFFFFFHHFHHJJIIJJJIJJJJJIJJJJJJJIJJJGIIIJJJJIGHIIJGIJJJJJHEFBDBDEDEEDDEDCACCBDDCDDDDDDDDDDDDCCD@ADD
@8W2
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTTACTCTTCTTTTTCGGGGGGCGC
+
@@@DDDFFDD<CDHGHH?BGBHAFHIIEDHCDCHIIIGIIGIIGHIIF>@DE=?E>CDCEEFDCEEACCCCBBCB##########################
@8W3
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHIJJJJGJJJJIJJIJHGGHGGIIEFHIGHIIHIIHIJIIIFFGHHFFFFDDDDDDDDDDDDDDDDDDDDDCDDEDCCDDEDDCDBDDD
@8W4
CGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGGAAGGACACGGTCCAGGTCCTCCACC
+
CCCFFFFFHHHHHJJJJJJJJGIIJJJJJJJFGIJJJIJJIIJH'936>ACCCC>A:>>:5;=28;(+555<BBB&5>?<18C?9@28>A@C44::>C39A
@8W5
TAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCT
+
CCCFFFFFHHHHFIIJHEIIJGF?CGIJDGGIIIIJIIJGIIIFGGGJIJJIIGIIGIGJHHHCBEFFF??AEEECDDDDDDCCCCBADDDDCDBCBB<CC
@8W6
CGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTG
+
?@@;B?DD?BA?DB?F>G:8+3<AF2?E8:D@8?DDFI:F@;B../)8@D266?>C7=@);>7@ABC@B?BBBBA><A?<@ABBB?BB<95905?A#####
@8W7
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJJJJJJJJJJIJIJIJJIJEGJIIJFIJJIIJJJJJJJJHFHHFFFFFDDDDDDDDDDDDDDDBBDDDD@CDEEDDDDEDCDDDDBB
@8W8
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFDFFFFFHFFGHII;EBBDHIGGIFGGIIIIIGGGGGHHHGDIHAGI>HECEC=BDFFCBBB=<CCACCCCCCBCBCCCC@CDC@CCCD::>@<B@B
@8W9
CTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTAAGGAA
+
CCCFFFFFHHHHHJHIIJJIJIJJJJJJJJJJJJJJJIJIJIIJIIJIJJJHHHFH;BEFFDEEEDEDDDEDDDDBDDB######################
@8WA
TTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTA
+
CCCFFFFFHHHHHJJEHC@EHEH;F<BF:??DH>>8=B<=C>CFE'-5;=E6=?B8/39(5:::888>?:49>::@@<<(34:@A@(::3>>8?(3<@C##
@8WB
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CC@FFFFFHHFHDGIIIJJIJJGIJJIJIJJIJJGICHIGHIIJJIIIBHJJIFEHHGFFFFDDDDDDDDDDDDDDBDDDDDDACCDEDDDDEDDDBB>B@
@8WC
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
@@@FFDDFHHHHHJJF=GGIJIIHIID<EG3DFHJJJJJIIIHGIGGGGIBE@CHHHHFFFFCDDDDDDDDCDCBBDB0<BBDC:4>BCDCDDDDA<599@
@8WD
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGCCTCAGAGGCGGGGGTCCCTCTT
+
@C?DDFFFHADBHIIIIIGIEEBGGE38)??:?83?D>@BGGEHA>@4@>16=AHEE@D7;BDEAAC##################################
@8WE
CAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCT
+
CCCFFFFFGFHDHGIJIIJGCHGIJIJJIIIGIJGHIEIHEHDDDDDCD?B?=CDDDDDDDDDDBDDD?8>9B5<<?CCCBB00<:A>AACEE>C@#####
@8WF
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
B?BFDDDDHFHDFBEFEHFABGGFHHFGHHGAGEGE<?9DDHAGGFGFGGBEHE:CEHF2;@A=>3;@CCD>AC?BD939@@CCDCCDDCDDEDDDB>BD5
@8WG
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTTCCTC
+
CCCFFFFFGHHHHJIJJHIJJJGJJJHBFCBHI<GFFHIJJJJIJFHCGGGFHHHFFFFFFDEDE>CCB@BCDCCCACCB?ACC>CCC?BBD#########
@8WH
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHFBHDHIJJJFJJJHIJJIIJIJJJIJJJIIIIIGGIJJJJJIIJHDHEHFFFFDDDDBDDDDDDDDDDDDDDDDCADAAC@CCECDDDDD<B
@8WI
AAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGA
+
BCCFFFFFHHHHHIIJIJHJJJJJJJJIGBHIJJJJJJJJIIFIIIHJIGIIJJJJJJJJIDEHABEFEDDEDDEDDDDDEDDDDDDCCDDDDDDDDDCDB
@8WJ
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCAGACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHGHHHIJIJJIJJJJJIJJJGHJJJIJJ<FHIJJJJHIIJFIJJJHHHAEFFFFDDDDBDDDDD(:?ADDBB@@CCACDEDDDDEDDD@>@<@
@8WK
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTT
+
CCCFFDFFHDHHHIJIJIJJIJGGI8?FF:@FE;DEHJIIJIJJIGIIIGJGHHHHHFFFFFFEEDCDACCCDCD>ABCCCDDCCC?@>B###########
@8WL
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJIIJIEIIIJJIGIIIJBHIGGIIJJJJJJJJIIJJJHHHHHC?BBEEDAB@@BD>5:@CB(05>DDBDCDDEEDACDEDDD@BB@B
@8WM
CTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAG
+
@@@FDBDFHHHAH>GG<GCHIJIEAB0@FGCFDAGFHFFD>@B?BDDB?9257?A?CDDBBDBD@?BDB<C?BCDB@B@BD4@CDACBDDB3@199>CC3>
@8WN
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHGHGGIJJJJJJIJIJJIGIIJJJJIIIJIJFIJJJIGIJJJJIJCHHEEFFFFDDDBDDDDDACDDBDDDDDDD>ACDEDDDDEDDDD@BD@
@8WO
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CC@FFFFFHHG<?FGBHIJEHIGHBHIIIGIJIJIHHDFEIG>FHJIIJGIIIFEHGHFFDFBCBBDDCCCDCCDDDDBDDDDDDDEEDDDDEDCA@3<B>
@8WP
CCGGCATCCCTGTGAAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
@@@DDFADDHFHDG,CFGDGGFEDHIJJHGHHIEGIBB?F?@HIGGHGHIIGGCGGEEHHFDDAD;/5>ACCCDB@B>@BB@C@CCEEDCCDDDCDD####
@8WQ
TTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACTCTTCTGTCTAAGGAAT
+
CCCFFFFFHHHHGIJEHIIIEIIIJGBHJIFHIGGIGIJIIJJJHJIFIGEHFFEBEFFFFEECDCDCDDAAABDDBD#######################
@8WR
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDDEEDDDDEDDDDDDDD
@8WS
CTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGG
+
@@<DDDDFHFDAHEGF@GHCDGHEHEHBHHGBGIIIHGIGGIIG?B?DGGGGIGGHDGDGAE>AHH?B?>C?@>ACC@BCCA@@9<5@C@A:@CCCCC4:>
@8WT
CCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAG
+
CCCFFFFFHHHHHGIIIIJFIIGIGGIJIIJEHIIIIGGHIJIGIIGJIIIJJHHHHGEFFFDDDDBDCCDCDCDDDBDDDBDDDDDDDDDDEDDDDDDDD
@8WU
CCGGCATCCCTGTGGAGGAGCTCATCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAN
+
CCCFFFFFHHHHHJJJJJIJJJJ*@FGIJJJJJJJJJIJIJJJIJJJJJJJJJHHHHHFFFFDDDDDDDDDDDDDDDDDDDDDDDCEEDDDDEDDDDDDC#
@8WV
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
B@CFFDFFHHHHHIIJIJJJCHIJJIIJIIJIIGIJGJIJDHBHHIIJJJGHFDGHHFFBBDBDDBDDDCDD>BBBDDDDDDCACDCCCCCEDDC<>@BB@
@8WW
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTC
+
@@@<DDFDAFFHHIIIIIIIGEHF@@FAFAFEG@F6;FDD::F/CHEHIIIEHGFDFFFD@CCDE@>5=;;;ACD@C@<A?CCCD@@>??###########
@8WX
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHHHHHJJIJJJJIEHIJJIIIIEIIGGD@D8?DAF;FHIJIJJIGCHHFHEFDEDC:?BD>CDCCDD@BDD>BDCDD@CCDDDDA@C@D.@@#
@8WY
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJHIJJJIJJIIJJJJIJJJJJJJIHHHHFFFFFFEEDECDDDDBCDDDCCDDDCDCDEDDDDBBD<0<)(4:@4
@8WZ
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
????;==D?CD<A:C@E1FE>9AF99<EEEE@DCDD>?DDIIIIDIIIDAA@C;ACCAC@DD@@???AA>AAA?A?>?>?><AAABAA>::>A########
@8X0
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACCCACGACCTGTACATGATCATGCGGGAGG
+
@@CFDDDFFHGHBHIIG7@C<CFCHHC?D@@>GGGEGFFHBDHGGHCBGA6D9)7=6?ED('9333((5:5@(5,()5995A:>C@CAC33:4:(9<@###
@8X1
GCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGG
+
@C@FDDDDHHHFDGDHEHGDGIIHGGII@G??D>CF:AEGG<GGD@AE=EC;<B?ACC@BDD8?BD8?@CADD>@?@@CACDDB281?CDDDDACD<CC??
@8X2
CTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGGCACGG
+
CCCFFFFFHHHHHIJJJIJJJJJJIJJIIJEHIIJJIJJIIJJJJJIFHIJJJJIIHCHHGFFFFFDDDD09&(4>@>>:4:4@#################
@8X3
GGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGGGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGGCT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJGIJIJGGIGIFGHHFHHHFFFFDDDDDDA@/8=&5&534@550;?#############################
@8X4
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
@?+=DDFFHGHHGJIJIIIGGIIJJIIJGEHGGIIIIJGGGIIGGIJIIIIIJJGHHFHFFFDDDDDDDDDDDDDDBDDDDDCDDEEDDDDEDCDD@BDD?
@8X5
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHHHHHJIJJIJJJJJJIJJJJFJJJJJJJJIJJIJJIJJGJJJJJJJHHHGFFFDDDDDDDDDDDDDBDDDDDCDDDEEDDDDDDDCDDD>B8
@8X6
GGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGGCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTG
+
@C7DDFBBFFFHGIIIIIGGIDGGGGIGD>DDHIDEHGIHGG=CEEE>>/=A?B>BD=BDDCC>@>C>AC:;9?B9?B8<>@<5>8?ACCB@><<A>A###
@8X7
CAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCT
+
CCCFFFFFHHHHHJIIJJIJJJJJJJJJGIIIIGIIJJIGGHFFFDDDDDDDDDDFCCDDDDDDDDDDDDDDDBBBCCDDDDDDDDCDEEDEECDDD>@B@
@8X8
CTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGC
+
CCCFFFFFHHHHHJIJJJIIIIJJJJJJJJJIJJJJJJIIJJBEBBFFEEEDDDBDDDDDBDDDDDDDCEDDDDDDDDDDDBBD905&9+9>:@9999?::
@8X9
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGGCGT
+
CCCFFFFFHHFHHIIGHHIIJJJIJJJIGIIJJJJIIIIIJIIGEHGHGHIJCCECCCEFFF;ACEDEEADDD############################
@8XA
CGGTATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTC
+
@B<BDFFFHHHHHJJJJJJJJIJIJJDHFHGIJIJJJIJJJJJJJJJJJJJJHGFFFDDCDDDD?CDDDDDBBBDDCDCDCDAADDDDDDDDDDDCCDD<?
@8XB
GGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGCGCGGAGTCT
+
@@@DFFDAFHFDFGB8DH)CBGDGHEGGHE<GGBHHIIGHHFHEF@BC>AAABBBAB8;87@8>4@C>@>98::>A@C3>@@>409<?BB@##########
@8XC
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHHHHHJJJJIJJJJJJJJIIJJJJJJJJJJIIJJIIIJJIJIJIJIIHHHHFFFDDDDDDDDDDDDDDDDDDDDCDDEEDCCDEDDDDDDDD<
@8XD
TGTAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTC
+
@CCFFFFFHHHHHJJJJJJGJJJIJHIIJBHIJHIIJJJJJJJJJJJIHGDCDEDDDDDDDDDDDDDB;B;BBCCCDDDDDDDDBDDDDDBBBDCDDDCCC
@8XE
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
BC7DDFFFHHHHHJJJJJJJJJJIJJJIJJJJJJJJGJJJJJIIJJJJJJIIIGIHGHHFFFDDDDDDDDDDDDDDDDDDDDCCDEEDDDDEDCDDDBDD8
@8XF
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
@@@ADDBDF?FFFEEF7<3<CF>H>?B<E*:1?FDFAGEDBE<D7FAA@/@=A.=EEFCD;/=9;;BBA:A:A?B@3)5<<3+44434>AA>AAA######
@8XG
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTGCCTCTT
+
?;=DDADDDHHHBHECCAFHGGBGHE:EE6GD<?@F>FGHEGGG@@FCDHD@CA=CHF;@DFD>CAA=(5=>>@>>:<>?C>>>>528>BB##########
@8XH
CGTCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
@B1BDFFFHHHHHJGJIJJJJJJJJJJGIIJJJJIJJJIIJIJIJJJJJIJJJIJIJHGHFFDDDDDDDDCDDDDBDDDDDDDDDEEDDDDECDDDDDDD?
@8XI
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGT
+
CCCFFFFFHGFHHJIGGGHIIJJJJJJIIIJIJIJJJIICH@GHIJJJJJJJHFHGHFFFFFCCEEAACCDDDDD599@ACDDCC3::A@###########
@8XJ
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
@CCFFFFFGHHDAGGGIIGIHHIJJJGFHGAG3CBFFEH=F:@DHGHGIIHEAEHHH2AD2=C''9?C?>@CD@B/55><-34>@D<((:A:AAA######
@8XK
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGG
+
CCCFFFDFHHHGGJEGGIIJIJJJIGIGHIHJJJJJHIJIIIIIIIJJJJDGEGIHHHHFEFDDBDDCDDDDDDDBB<BB@CACCDECCCDED@@@D<BB#
@8XL
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
@C@FFFFFHHHGHJGHIGIJJFHHGIIJJIGIIIGIJJJ?<FGHIJJJIIIJHEHHEHHDFFCD@BDCAAADDBBD@BDBDDCCCDDD@CDECCDD>9>B2
@8XM
GTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCA
+
BB@FFBDFHHGHHJIIJJJHGGIJCHIIJFHG9DDEGHIBFHIJBCGIIGGCEHII@GGCHEEHHEFEFFAED?DB<09@CCCDDDBDDDDDDDDDDDDB@
@8XN
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHHFHGIEHG;FHIIJJJJJIJJJIJIJJG>FHFIIJJHHGIIBGHIIHHFGEDFDDDB?CCDDDDDD?95<@<?@@CCDCA:@CCAA@B<>B2
@8XO
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAGGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
@@@FDDFFHGGFHFBIBHGIIGIJHEHGIJIGJBHDEEGD<FGFGHIIH'5B@DDE(-5?BCBD@DBCCDDDDDBBBDBDBCCCDEAACCDEDCCDB<<@2
@8XP
TCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGGCACTCT
+
@@<DDDDFHHFFHGII3<ACHIHEGEHDD?DEHE6BBB@@AGHGIGIFEIIF;?AADFFD@BCCCAEBD;>A@@CCDDDCCCCDDDDD<BD##########
@8XQ
TCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGGCACTCTTCTGTGTCGGTGGGC
+
@@@FFFFFHHHHDEEGGBGFFGHIJIIIIGBFGAGCHCHDAGCCHIGGIJJEFF=BCEFFFEDDACCDDCCCDDDBD&0&(3(+94>>>:AA@########
@8XR
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGTCC
+
CCCFFFFFCDHHHIGEHIIIGIEGIIGGHIIGIHIIGIIIIGIIIIIIII@DHEHFEHHF;@BEEEEEDDDD@############################
@8XS
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHHHHHJIJJFHIJJJJJIIJJJJJJJIJFIIJJJIJJJIJIJIJJHJHHHHFFFDDDDDDDDCDDDDDDDDDDDDDDEEDDDDEDDDDDDBD2
@8XT
GTGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCAT
+
CBCFFFFFHGHHHJJJGIJIJIIJHIJJJGJJIJJIGIJJEFDFFFFFEDDDDDDDDDDDDDDBDDDEDDDDDDD?BDDDBDBBB&5(+::@9<5>B>@##
@8XU
CTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAG
+
CCCFFFFFFHHHHJJJFHHHIJIJJJJJGHIJJJFHIIJJFHHIJJJJJJJHIJJJJJJJDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@8XV
CTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCG
+
CCCFFFFFHHHHHIJJJGJJJJHJJHHIIJJJJJJJGJJJJJJIJIIHHHHHFFFFFEECDDDDBDDDDDDDDDDBCDDDDDDDDDDBDDDDDDABBDDDD
@8XW
CGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTTTCGGGGGGGGGCACGGGAAAGAN
+
B@BFFFFFHHHHHJJJJJJJIIJJJJJJJJJJJJJJJJJJJJJJGIHIIJJJJJJJJHHHHHFFDD###################################
@8XX
TCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGGGCTTGAGCAGTCCAGGTN
+
=8=BBDD;CD<AAH<<?<CFH?8ECDBECDHGID>B?BBBFDG9(83BF@F9FH@A7CACH:A3?B@C@BCC?;;;ACC938?=1(5<8@###########
@8XY
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGN
+
B@CFFFFFHHHHHJIJJHIJJJJJJJJJJJJJJJJJIIJJIJIJJJJJIIJJJIGHHHGFFFDDDDDDDCDCDBDBDDDDDD@CCEEDDDDEDDDDDDDD#
@8XZ
GGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJIJJJIJJJJJIJJJJJJJJJJJJJIIJJHHFHFFDDDDDDDDDDDDDDDDDDDCDDEEDDDDEDDDDDDDDD?
@8Y0
TTCCCCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTA
+
BBBDDFFFHGHHHJJIGIJGIIJHHIJIGIIJIGHGEIIJJJGIHIFHHHFB;BCCDDB?CDDDDDDDDCDDDDDDDDDDDDDDDDDADDDCBB<ACAAC@
@8Y1
CATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCT
+
CCCFFFFFHHHHHJJJJJIJJIIJIHIIJJFCHGIIJJJGHIJJ(@FIJIJJJJJIHHFFDDDBDDDDDDDD?@D@BDDDDDEEDCDDEDDCDDBDDDDD@
@8Y2
TCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGG
+
@@CFFFEFHGHHFIIIIJJJIIGIGIIJJJIGIICHIJGGIJDGIGGHEHEIICGHHFDB<A>?CCDCBB@/;?B@ACCCC@>CCDEACC>9<9>8<CDDD
@8Y3
GCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGC
+
CCCFFFFFHCFHHJJJGGIJJJGJJGGDFFFDCDDDB??A@BD8@DDDD?BDDCCDDC?@D&5?CDACCA9>BBBDBCCC>C:4>BC<C?@CCCBDD@DB8
@8Y4
CCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGC
+
@CBFFFFFHHHDHIJJJJGIJJIJHIJIJJJJJJJJIIIJJJJJJJJJIJIJIJJHGFFDDEDCDCDDBDB;BDBDCCDEEDDDDEDDDDDDDD@BCDDC?
@8Y5
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
CCCFFFFFHHHHGIJIFEFHIJIIIJJIIJJJIJJIIEHIIJJIHHEHGFFFD=CDDCBDB@DDCCDDDDD?BBDCACCCDDD?CCDD8>?CDAA>>AACD
@8Y6
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTTTCGGGGGGCGGCACG
+
CCCFFFFFHHFHHJJFJHIJJJIJJIJGHIIGIJJCHFGJJIGHIIJIJJJJ?EHHHFFFFFCEEEEEDCDDB############################
@8Y7
CTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCAT
+
BC@DFFFFHHHHHJJJJJJIJIJJJJJGJJJJIJJJJJJJHGIIIJIJJGIJJHHFFDDEEDDDDDBDBDDDDDDCDCDDDDDEDCCBBBBD28ACDABD>
@8Y8
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTTGGTGGACGT
+
CC@FFFFFHHHHHJJGJEHIJJIIEIJIGGIJJIIIIJJIECHIGGJIIJJIHHHHHFFFFFEEDEEEEDDDDDD##########################
@8Y9
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTGACTCTTGTCGGGGGCAGACACGGG
+
@?@ADDFD:AFHDFGGGBDG>GGA7<BFGB@>F2;?F@@FHEIIIIIIFA@@AEHEHHCD;@DA;66@AB###############################
@8YA
CTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCAT
+
@B<DFFFFHHHGHJJJJIEHGIIJIBHIGGGIG@GHEGIBGGHIJBGHIHIJJHHFFBDE@CCDDDDDD@B@BCCCDEC>ACDECCDDDBBB<ACEDCD?>
@8YB
TCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGC
+
@@@FDDD>DFDFDHGGGHIGEHDGEGHIIBHHHBGIEHIFH=BD86;A?BBDD@C@CCCDCC@DB8@D78259@&5<?ACCB<99?@@@>:>CC@C@@>>?
@8YC
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTC
+
BCCFFFFFHHHHHIJJJJJJJJJIIJJJHGEGIJIGGEGIJJIJJJJJJJIEEEEFEFFFFEDEEEDDDB??CDDCDD>BCCDDCCCCD@>B99>5::>>4
@8YD
CACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCA
+
@@CDDDFF<A?FFBHG?B@AGDCGCCBGGHI<F?9B???BA?D8/=F<F8C7@=4@;D>D@CH;.=CBDB37;@(.;AA?A>:?CCC?A?@(:?4>ACC9<
@8YE
CCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACTCCTCTGTGGTCGGGGACC
+
@<@?DDBDDFHHHGGIBG?BF>FB>0?B>FECBEGGDGGEGIHIIGGBGGBGEEH;>B;.;@?;;>AC@>CB?=@##########################
@8YF
GGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCG
+
CC@FFFFFHHHHHIJIJJJJJIJJJJJJJJIJJJJIJIJJJCGHIJGGIJJHHFFEDFDEDEDDDDDDDDDDDDDCDCDEDDCDBDD@?ADDDDDDC?>A>
@8YG
CAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGG
+
@8?BDDDDDF=?FAFEBE?3<EAGIFF>F:?F@:@BC9B;F@FEFF9=C@;=;F@DFI:3).77?@B);(6=@BAA3(,;?B((5:99<@B3:?B<3<8<2
@8YH
TGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTT
+
@@<DDDDDHHFFFHF<AA+CB@BFG;11:C):C?DEHIBAGFDB)??FDFFF4BC>3==CD;EHGHEEBDB5;?9>:?BBBBBBB990+(58?@BB@BB?1
@8YI
GGGCCTTTTGCTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIIJIJJJJJJJJJJJJGDGIIJJJDHGHGCHHFFFED@CECECDDD>@BBBD9@?CCCDDDCDA:A99??@595
@8YJ
CGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTGACTCTTCTGTGTTGGTGGGGGGCAC
+
CCCFFFFFHHHHHJHBGIJIIJJJGGHIJJJJGIIIIJIJJJJIHIIII=DGIFHHFEH@DFFEE@CDDDDD#############################
@8YK
GCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJHIJJIJIJJHHHHHHFFFDDDDDDBDDDDDD@DCDDDDDBDCDCECDEEDDDDDDDDDDBABDDB@BBCCD
@8YL
GAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGC
+
CCCFFFFFHHHHHJJJIIJJJJIJJJIIJIJIGIGIJIJJIJIJIIJDHJJHHFFFFFEEEDDDDDDDDCCDFFDCCDEDDCDDDDD<ACDDDDDCBCDDD
@8YM
AGGAGCTCTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGGCGCG
+
<??DA=DB:CDDDDEEIAE++AE;AA))1*:?*?D0@8?D*?(??;('''5A;=7=;@3?@>@8;:=?>;:>BAAA#########################
@8YN
AGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCG
+
@@@FFFFFHGHHHHIGIIJIEGFGCHIJJJIJJJIGHIJIIJIHCHIIJJFFHHFFFFFEDD@BDDDDCDCDDC:;@DDDCBBBDD(8ACD:?CCDD>>B>
@8YO
GGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCG
+
CCCFFFFFHHHBHIGIIJIFHHGGGIIGEGHIJJJJJJGHHICBFHI8AHHGGEDFFFFEDDDDDDBDACCEEDDDCDCDCDDBBB(2:>CC?CC<C@9BD
@8YP
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
CCCFFFFFHHFHHII6@?GE>GGG<FH>BGHH4DH?DE>AHHIGHGH?EB'595;ACCDDDDD:@9>CAC?(88>>CC:@@CC9>>?B2>C@AC:@CA9><
@8YQ
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTC
+
CCCFFDFFGHH?HCBG9EFE@E>;EBFGHGGGGG0(9BBFHGGIHG@EECEHHAC>3@BFEECECCC;??;?CCCCC<@A>?CCACAC??B##########
@8YR
AGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCG
+
CCCFFFFFHHHHHJJIJJIIICIGIJJIIIGGIGJIBHD9BDBGIIFGIHGBHHDDFFFEDDDDDDDCCCDFECDCDDDCDDD<@B<?A@CCB?CBDDDD@
@8YS
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
CCCFFFDAHHGGHIIGGGGHGGEGGAEHEGEHGGGHGGIIIHGGI>GGHEIEEFBDE>=BBBD?=8?>::999;?A@CCDC=@8ABCDCDCDDDC?A>8?2
@8YT
GGAGCTCTTCAAGCTGCTGAAGGTGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGC
+
@@@FDFFFHFFHDIGIIIFIJII:CGIACEGHEHIJIIGGGICHIJEIJEIGFEHHFEFFDDDDDDCCDDDDCCDCDCCDBDDDD@BDEDCDDCDDC>BBB
@8YU
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGCGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
???DDDDDAD<?@CDDE:;4*?):@@A*99DCBBD*B@DAD?D/@/.->>8'9;8?=A8507?>><AA>38(2<>>>:A######################
@8YV
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGATTGCTGGCATGCCGCGCC
+
CCCFFFFFHHHHHJJJJJJJJJIJIJIJIJJJJJJJJJJJJJJJJGJJJJHHHGHFFFFDDBDDDDCCCEDDCDD@CDCDBDD&>?CDDDDDDDCDDDDBD
@8YW
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
@@@FFFFFHGHHGEHIIHIJIJIIIJIJIIIIIJJJJFGGHJIJGEFFEHGFEHHFFFFDDDDDDDDCACDCCCDCCAA@BBBB8?@DCC@CDDCAB<BD>
@8YX
GTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTGTCGGTGGACGTCACGGTAAGGACA
+
CBCFFFFFFHHHHJJIIJJGIJIJJFIJJJJJIIHHIIGJIJJGIIGIJIIJJFEHGHEHHHFDDD&0&&2>@CA:3>:-0&+98>905@@##########
@8YY
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
CCCFFFFFFHGHHJIJIIJJIEIIIJBGHIIIIJJJIJJIJJGIGIJJJEHHHHEFFFFDDDDDDCDDDEEDDCDDDD@BBDDDDDCCCC@CDBDDBDDD9
@8YZ
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJIJJJJEGIIGIJIJJJJJHHHHHFFFFDDDDDDDCCDFEDDDDDDDDDDDDDBDDEDDDCDDDDDDDDD
@8Z0
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
CCCFFFFFHGHHHJJIIIJIJJJJJJDHBHEGGEAGHBAGHGHGIIJJJJGHHHHFFFFDDDBDDDDACDCDDDDDDDDDDD<B<?CACDDCCDDDDDDDD
@8Z1
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGGGGACGTCA
+
@@@FFFFDFHHGHGHFGGIJIJJJIGFEHIGGGDGIIEDHHGIJIIGHIJ@EHCHHHHGDFFEEEECCDDDB#############################
@8Z2
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
CC@FFDEFHFHFHJIIJHHHEHGIIIJJJFIGHB@FH@GFHG?C=AAAEHHEAEHFFFFDB@>3;<:5@CDDCCC>:4:99BBBBACCC@@CCDCC#####
@8Z3
ATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCCCACACCTCAGCACTCTG
+
@@CFFFDDHHGHHJGGHG<IIIG?FHIIJBHHIII@BCDDCGHGBGICGBEFHIDHEIIGBEIII@AA?=?BB;A@CB?7;@:?9@BDDDDDDBCCDCDDD
@8Z4
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
CCCFFFFFHHFFHIIJCEAEFBFHAGGIIIJDIIIIIIJJJJJJJJIJJJHGFFHFFFFDD@DD@CCCDE>CCACDD>>@BB>BBBDEDDDDDDD3&9@##
@8Z5
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCC
+
@@@ADDDDHBD<FAHADGGII9FEGIIC)CF:FF@GGAGGHIIIIGHIGIHHFHHDEE?AA/>?BC>CCCDCCC>@CCC@BBBB8ACACA<?@BC######
@8Z6
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTCTGTCGGTGGACGT
+
CC@FFDFFHDDFFHJBGHIIIHGGGGIGDGGAFHFBGHIGIIHIEIJIIGIG?CEHHBDFFF?ACCEECDDDDD###########################
@8Z7
TAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCAT
+
<@@FDDDFHFHHBFHGIJJCHGBHDDEBDFGIHH<?DGBB4:=;BC;@;;?=?B:;99,<8@@B;>:>@>9AA-0<?B2&<<@59<@(9::><@BD?####
@8Z8
AGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCC
+
@@@DDDDDDD??CBGHBGFA:AAC8<?CDBFHFFHIIFGGDHBCGGI@@1===AEEEEC>A;;8?>A>@CC>5,>>33)0--)<8@CC>89>@>CBBB9<B
@8Z9
GCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGG
+
CCCFFFFFHHHHHJJJIJJJJIJJIJGIIJJIIIJGGIHJGGFHGIJEHGHFFBEFFEEDBBDDDDDDDDDDDDDDB9CCDDDDDDDCDDCDDDDDDDDB5
@8ZA
CACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCG
+
CCCFFFFFHHHHHJIJJJJIJJJJJJIJJJJJJJJJJJJJGHHHHFFFDDDDBDDDD?B<CCCDDBBDDCCADEDDDACCC>@DBDD98<B@@3>8ACCC<
@8ZB
GCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCT
+
@@@DADDBF<<FHIIGIIFEEIGGGH??CFEGGCGHHEGGHIG6A;E8AH973?3;?B>88;??5>@@BA:;>A>@595@<<88>AC@?C###########
@8ZC
TCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAG
+
@C@FFFFFHHHHHIIEHDBF?F?BDGIIFGIC?DFHI@FGGGEG<FCCHHEE(9<B?B;CCCD==@7?:>?@CCC??B?>4>CCC>@C9@CBB2>9@A>@C
@8ZD
GCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCT
+
CCCFFFFAHHHHHIIJJJJJDIJGFEHGI0CFHIIIGIJJGIGIIGIIJHHHHHFFDFDDBDDDDDDFEDDDDEDDDD@BBD?BCEDD@DDDDDDDBBBB@
@8ZE
GCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCT
+
CCCFFFFFHHHGGJJJJJJJJIJJJJIIJIJJJJJEIJJIDIIGJJJEIHHHGHFFFFDDDDDDCCDFEDDDDEDDDDBDDDBDDEDDDDDDDDDDDBBD9
@8ZF
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGGCACTCTTCTGTGTCGGGGGACGG
+
CCCFFFFFHGFHHIIIJHIJJJIJIJJIFGIGGGIBHIIIIGIJJJJJJIIJ?EHHHFFFFFDEEEEEEDDDDDB##########################
@8ZG
CGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCT
+
CCCFFFFFHHHHHJIJJJJJJIIHIIJJJJJHIIIIGIEHHHHHFFFFDDDDDB@?@B=B;@<CDDDDDD;BDCDADDEEDDDDD>BDDDBD@DDB<><CA
@8ZH
TGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTCCACC
+
CCCFFFFFHHHHHJJJIJJJJFHIJJIJJJJFGIIIJIGGIIJB,996.>(;5ACC:>:>>;@??B?CD9>(()928?3>3<A<99+8>>@C:AACCCCC8
@8ZI
GCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCT
+
CCCFFFFFGHHHHJIIJJFIGIIIJHIJIHIHIBHHEBHIJJJJIAAHJHGHGHFFFFDDDDDDCDDEFDDD>CCD@>BB@B?ACDDDDCCAC><BBDBDB
@8ZJ
CGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTTCTCGGCTCCGTGCGGAGTCT
+
@@@FDFFDFHDFFIGIEGIIGDHHIJJIGIJIFHIJFIGHFHFHFFFFDAB?BD??@=/;&083(4>8@B@@<A::A(:@#####################
@8ZK
CTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTC
+
C@CFFFFFFHHGHIJJJJIIIIEHHIJGJGIIIIIJJIGHJIGIIJIJGFHHHHFFFACDDDDAACDD;CCD@CC>>>@-52<C>@>B?:A@CBB<>@BBB
@8ZL
CTCTTTAAGCTGCTGAAGGAGGGCCACCGCATGGCCAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTC
+
???DD8B2A2ADDEI<EEEFDFI:F1EEII@DDI)??DAD@D@A>ADDDDDDD<@D?@@????A355;A(5>AAAA?>>508>>A:A>?A?AA>5;>????
@8ZM
TCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCN
+
@@@DDDDFHGDHHJJJEDFGGB@GHGIJJGGGGEHJI;;D?@GGGG?HGHEEHEEFDBA>?DA@CDDCC>@C::A?BB-9(8:CCD@CDDCC@########
@8ZN
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
CCCFFFFFHHHHHJJJJJDIJIGGGBG@GFIEHIIGBIJIJEHGIEIIJIJHHGFFFC?BBBB@BBDDDD@9BBD@ACC>@CB?BDCCC>>@CCC9@C@D2
@8ZO
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHGGHJJIIIJJIJJIJJIIJJJJIIJJJIJJJJIJJJJJJHHHHFFEACDDD@CDFEDDDDEDDCDB@BD@BCDDDD?AACDBDDDDDDBDD
@8ZP
CCGGCTCAGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCGCTCTTCTTTGTTGGTGGACGGC
+
CCCFFAF2ACDFHGGG?FHIIGGGIIIIEEHIIIDGHBGII@HIEHFCHEGDHCHGIDH<EHFFFDD@CDDBDD###########################
@8ZQ
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJJJJIJJJJIJJJJJGHIIJJHJJJIJJJJJJHHHHFFFDDDDDCDDEFDDDCDDDDDBDDDDDDEDCDDDBDDDDDDDCBDB8
@8ZR
CTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCACGG
+
CCCFFDFFHHHGHIIIIJJJJJIGIJJIJJJJJJJJJJJJJJGIJJICFIIIJIJJHCHHHFFEFFDDD################################
@8ZS
CTTCAAGCTGCCGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHGJJJJIJJJIJJJJJHIJJJHIIJIJIJIIJJHHHFFFFFEDDDDDDDDDDDDFDCCDEDDDBDDD>8?CDDDDDDDDDDDB>BDDDBD
@8ZT
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTTGGTGGGCGG
+
CCCFFFDFHHHHHIIHJHIIEHGGGIJEFGIJGIIGHIJJGAGGIIGIIJJJHHHGHFFFFFBCEEDECDBDBBB##########################
@8ZU
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
@@BDFFFFHHGHHJJHEGGEHJJJJIIIAHEH@GHIJIHIJJJBGGCEHHFHHFFFDDDDDCD@>CCDDDEDDC@@BD<?AC@CC8?@ACDBDBDB9>B@<
@8ZV
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJIJJJIIJJJIJJJJJIJJJJJJJJJJJJJIJJHGHHFFFDDDDDDDCFDDDDDEDDDD@@@B?BDDDDDDDDCCDDDDDDBDD@
@8ZW
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
@CCFFFFFHGGHHJJIBHIIJDIJJJJJGJJJGIJJJJIJIIGIJJJJJHHFG?DFDDDBD@ACDBCC@CCCCCB09BB8AADCABCCBDD>B@B@99?B?
@8ZX
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFDFDFHFHHHJJBFGGIIDHGIIIHIGGICIGJIGICHIIGHI@AD@EEEED<ABDDCDCDCDCDDDEDDDB@B9>28@C>>@CCDAC@@@BD@BBD@
@8ZY
TCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCGCTCTTCTGTGTCGGTGGACGTC
+
@@@DDDDD12<CFAHICCEFH:GHHD9:?BGF@FGADF<CBDGEHFFFHGH6?;>?EADD?CECCA>>CBB=B############################
@8ZZ
ATTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTG
+
CCCFFFFFHHHHHJJJJJJJJJIBFHIJJJJJJJJJJJJJJIJJJJJJJJJJJHHHHHHFDFFFDEEEDDDDCDDCCCDDDCDDBDDB#############
@900
CTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGT
+
CCCFFFFDAACFFJBFHGGDIIICGHHIHEIEEHIIIGII9FHGGIGIIGIIIGIEGIEEEH>CEFEDEC@@ACC=CACCACB@BCDDC9A@:?@CCCAC@
@901
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACTCTTTTGTGTCTGCGGGGGT
+
@@?DABBDHADHD:E@@F@>DCA>DGGHFGGGG@B2BCHEEH;C=7@HDHE;.=AHFEB@3;76@>;@CA;@B############################
@902
CAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGGGGTTGGTTGGGGCT
+
@@@FDADDFDFFHGEHIG<FCGEHA;@FHIIIBBFEH3DGHFE@CCFEFHEG@EGGEEHEECE.?BCCCEABCCBBCAB??CB<AB###############
@903
CTTCAAGCTGCTGGAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
@CCFFFDDHHHGFIGGIIIEGIGCHIGJJJJIGIJIICEHGIIIIJHEHHHEEFFDDDDDDDDDDFDDCDECD@BD><>BBDEDDDDDDDDDBBBBDDDDD
@904
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
?@@DDDDDDBFDD@BAFGHAHIIAGHIBGGGI?*BDG?HEEBHBBHCC)=?EHB?DBCBB?CCCCCCCCCCC::;B>95?ACDCC??CBCABB-09<BBBB
@905
ATGCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCT
+
:@+=BDDDHGHHGJJJJIJJHIHEFHJIJIJFIIIJCHIEHJEGG@FHDGFH:?DDABBB<CDCDDDDDDDCCDCACB<BDDDDCDDCCCDCDDB8>CDDC
@906
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTC
+
CCCFFFFFHHHHHJJJJJJJJIIJJJJJFIIGJGJGHIIJIIIJJGGCGJJHHHHFFFFFFEEEEEDDDD=CCDDCDDDDCDDDEDDDDDDDB########
@907
TTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGT
+
CC@FFFFFHHHFHJJAHIIJIGDGGGGGHDEGIIIFJ6C@=BGGGIF>DEEGGHHHGFFEFFFD;CEEDDDDDBCCACDDDDDDDDD>B############
@908
CGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGGAA
+
CCBFFFFFHHHHHJJJJJJJIJJJJJJIJJJJJJJJJIJJJJJJBGHJJJIJJJEHJHHGHHFFDDD&50(+:>CA:3>>AAC##################
@909
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
@@@ADEBDFDFFHIGAE9GBAGIFGIIIGEGG<BFGDEGGB;F@GG7CC>EEEBDEBCB?5-;@C@CCCC>5(583005+8:::42<CBCC5&05>5>?<?
@90A
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJIJJJIJIIJJIJIJJIJJJIIJIIIIJJJJJJHHHHFFFCDDDDDDDDDDDDDEDDDDDDDDBBDDDDDDDDDDDDDDDBBDDD
@90B
GTATTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCA
+
@@CFFBDFHGHFFEEHGGCHGGEGIGIIIIJJJJAGEHIJGDD@FHIA;C=F@EHJGB@EEHHHGFFFEFCCECCDBDD?>>ABDDD?CCDCBDDDDDDDD
@90C
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFGGBFFGHECBGIIIIIIIGGIBIJHJGJHIIJAEIGIIGIIHHFHFFFDDBBDACDDCDDDDEDADBBB>BBBDECDD?CBDD><BDDDDDDD
@90D
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTGTCGGTGGACGTCACG
+
@B@DDFFFGDFHHJIJG?FGGGIGIIIGHGIGIIJJJGDGGHGIIGJGIICHHFEEHFFFFFBCCEEECDDDDBD##########################
@90E
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJIIGIIIJJJJIIJJJJJJJHHHHFFFDDDDDDDDEDDDDDECDDDDDBDBBDEDDDDDBDDDDDDDDBDDD
@90F
CTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTGGGTGGACGGCACGGTAAGGACACGGTCCAGGTCCTCCAC
+
@@@@DDEDHFDFHIIJJIJEGI@GHGHGHJIJDHGIGJCHIDGIG'0008@@C(:333+::((0)05(4)&&)055(+8>>(89?@B(20(+9:A@@@>9A
@90G
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGGCACTCTTCTGTCTAAGGAATAGG
+
CCCFFFFFHHHHHJJGJJJIIJIJIJJIHIIIIIJGIJIIJJJJIIJJFIJJEHFHHFFFDE@CEEDEDDDDDDD09&(+:<C@C>>:@>:+:(9:>>AAC
@90H
CCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTAAGGAATAG
+
CCCFFFFFHHHHHJJJIJIJJJJJJJJJIIJJJJJJIIIJIIIJJIGIJJJJHCHHFFFFFFDCEEEEDDDDDDDD&553?ACC@A:>(:::4::?4>>:>
@90I
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
@BCFFFFFHGGGHIEIIBGGIIIIJIHIEHIJHDHGIIIIJIJJGIJIJHGHHFFFDDDDDCCCEECACCEDDDDBDDD@?CDDDBCCBC>BBB>BBDDDD
@90J
CCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGGG
+
CC@FFFFFFFAFFHAEFHGIBHIGGIIIIIIIG?FHCFIG=FEHIIAHHGGHCAECFBDEEDCAEED?CCC>CDD@B>BB#####################
@90K
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJGJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJHHHHFFFDDDDDCDDFEDCCDEDDDDDDDDDDDEDDDDDDDDDDDBDDDDDD
@90L
ATTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACCTTTCTT
+
:??DA42:CB<DDEACAEFIACA<C@EDDD??DB9DDDDID.8AA@DDDACAC;7;7=AD3;@?@6>>AAAAAA>5:9>A>AA??################
@90M
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
CCCFFFFFHGFHFIIGHFGGHIGHGHJDGGIICHIGHEHEGIJIJGAEHHBDCBDDDDDDBDDDCCCCDCD?BDDCCCCDDDCDDDDD?CDDDCCCDD?CC
@90N
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCA
+
@@@DFFFFHFHHHJIGEGIIIIIIIGIJIFHICCHIEHICGIGGGG>DHHHGGFFBADDDD;>@CDDCCCD@@>@9<<B?2:>>ABCCACABD05>@>B?#
@90O
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFDDHHHGFEGIGHCEHIIGJJJJIJIJFGIIJ;BFHIJGIIAEH@EEHFFFADDBDDCCDF3@CDEDCDBD<@B?ACCDCDDDDDCBB@DDDDBDD
@90P
CTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACTCTTTTCGGTGGGCGC
+
@@@FFDFFGHHHH<EGGIJGIIJGHGGIIIJIFHEHIGIGGIIJIHIIGIHHEHHHDFFFEEEEEDECDDECDDDDBD#######################
@90Q
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJIIJIIJJIJJJJJGIIIJIIHIHGIIIJJIJJJJJHHHHFFFDDDDDDDDEEDDDDEDDCDDDBDBBCECDDDDDDDBDDDDDDDDD
@90R
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CC@FDFFFHHHHHIGGIGIIJBGGJJGIIFGHHGHIJJGHIGGGIIGGEHHHHFFFDDDDDA@CDDDCCCDCCDDB@BDBBCEDDDDDDDC<BDDDDDDDD
@90S
ATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTC
+
CCCFFFFFHHHHGJJJJIIIJJJJJJJJJIIIIJJJJJJHHHHHFFFDDDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDBB?CDDDDDBDDCDEDEDDEC
@90T
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
@<@DDFFFFGFHDEGGEFGGIIGGIHHHFG=FBFCHBHHEBHIGIIFEGHHGHFFFBDD?C>ACDDDDDDECAAB59B-+8@CACDDC?@A>@D<@@>ABB
@90U
CCGCCTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTGTCGGTGGACGTCACGGTAAGGACACGGGCCAGGTC
+
CCCFFFFFHHHHHJJIJJJJJJJJJIJJJJJJFHIJJJIIIJHIIJIJJJJJJJD,835;A@A@C####################################
@90V
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACATGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHIJIFIJJIGJJJH?GHH?HGHHBHGHJBIDGEHEEIIGAEHGB?CD?C5@CDDCCDDEDDDDBBB9?BDDCCDDDBCDDDDDB@BBDD
@90W
CTTTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCG
+
CCCFFFFFHHHHHJJJJJIIIJJIJHIJJJIJJJJIHIIIIJJGHIJJJJJJHHHHHFFFBCEEEEDEDDCDDDEDDDDDDDD##################
@90X
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
BCCFFFFFHHHHHJJHJJGIJIJJJJJIJJIJJJJJJJIJGIJJIJIIIHHHHFFFDDDDDDDDEEDDDDEDDDDDDDD@BDEDDDDDDDDDDDDDDDDDD
@90Y
CTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTGACTCTTTTCTTTGGTGGC
+
???DDB:0@D?DDEA@8C@CD?3?DDDDIIDA*B9DCCC@CD@CEE@AC;AA;ACD.;?AAA>A@@>A?ADB>;=<;?#######################
@90Z
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJJIJJJGIJJIJJJIJJJJHHHHFFFDDDDDDDDEFDDDDEDDDDDDDD@DDEDDDDDDDDBDDDDDDDDD
@910
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJIIJIIJJJJJJJIJJJJGHFIJIIJJJJJIJHHHHFFFDDDDDDDDEEDDDDEDDDDDDDDDDDEDDDCDBDDDBDDDDDDDD
@911
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFBEDHHHHJJIIIIJJJJIJJGIJIJJGIHIIJJJIIIIIJJIJHHHHFFFDDDBDCCDDFDDDDEDDDBB@9@@BDEDDDDDDCDBBBDDDDDDD
@912
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CC@FFFFFHHHHHIHEHJJJJJJJIJJIJJJJIGHIGIEEAGIIIIJGIFHHHFFFDDDDDDDDEECDCDEDDDDDDDB@BCCCCDDDDDCBDDDDDDDDB
@913
CTGATGGGTGGGCACTGGCTCACTGCCTGGACAGCTTGTGGGAAGCGAGGTGCTGGCAGAGTTCAAGGCTCTCTCCTTGCTCTCTGCTGTTGGGGTCTCGG
+
CCCFFFFFDHHHHJJJJJJJJJJJJIJIJJJIIJJIJGGIJJJIJJJJJJHHHHHHFFFFDADEDECDDDDDDDDCDDDDDDDDDDDDDDDDDDD9@DDDB
@914
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
C@BFFFFFHHHHHJJGHJIJJIJJJIIIJJJJIJJJIIJJJJJJIJJIJHHHHFFFDDDDDDDDEFDDDDEDDDDDDDB?ACEDDDDDDDDDDDDDDDDDD
@915
GCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTTACTGTTTT
+
@@@DDD?DFBDBFCAG@@FDGHIIHIEDBA@?BCHGGI?;FFF@>F@;;>=CHCAECHC?B?@;11(.;@CCCC@A>A?>@A>@<<>BB############
@916
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIJJIJJJJJJJGIIGGIJJIHHHHFFFDDDDDDDDFFDDDDEDCDDDDBD?BDEDCDDDDDDDBBBBDDDDD
@917
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
=@1ADDDEHHHHDGJIIJJIIGEGIJJGJJJIEHIIIGJJFIJIIIJJJGHHHD>DDDDDA@CCDEDDDDEDCDBDDDD??CDDCB?C?CCBD@DDDBBDD
@918
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJIJJJJJJJJJJJIJJJJJJJIIJGIIIGJJIJHHHHFFFDDDDDDDDEEDDDDEDDDDDDDD@BDEDDDDDDDDDDDDDDDDDD
@919
CTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTGTCGGTGGACGT
+
CCCFFFFFHHHHHJGHIJIJDHIHJIIJJJBEEGHIJJIGIIIJJJJJJJJHHHHG?@DFFDEDEDEDDDECCDB?=B9)50(:AAC3>:@4095?@<CD9
@91A
CGGCATTCCTCCTCGGATCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTC
+
@C@FFFFFHHHHHJIIHGFHCEHIDEGIGHIIJJIIGJGJJJJJEHGHIHEBHEBEF=AA6@?@BCDCC9@-9@CC3::>C<A?ADCCCCACDD#######
@91B
CTACAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCCCACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
:=:BDB?DDFBFA2<A;FIFD<1CG;:):0B@GCFCGB@FA@FE<DFIA)(7?DDC?BBBBBBBDB>A:(,(,5)&&)02<A@::?BBBB:509@B558<?
@91C
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
CCCFFFFFHHFHHJJIJJJJJIIJJIJJJJJJIIIGCHEEHIJJJJAGFGFFDBDDDCDBD@DDDDDDCDDDDDDCCDDDCDCCCCBDACCCCCDDDDCDC
@91D
CGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCA
+
@@CFFFFDDFFHH)@CGHIIIDIIIJIJJJJJJJIJJJJJGIJJHGGEF/9ACEEEDDDBDCCCCDCC@AABDDDDDCDACCCCBB8A9:ACCCCD9C?CC
@91E
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTT
+
CCCFFFFFHHHGHIJJJIJFIIIJJJIJJIJIJGGIIIIJJIJGFHHJJJIIHGHHHFFEDFFC@CDB=AACDDDDDDDDCCC>CDDDDB9&5002@:4:A
@91F
CTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAG
+
@CCFFF=DHHADDDGGIEGGECBGIIEBDH?FG?@GEDFGE;@GGGBH??DDDA?B@@ACCCC@ABB@BCCC@CC4:@?(48?(9?:4+:>CB9?<CCCCC
@91G
CCGCCTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTGTCGGTGGACGTCACGGTAAGGAAACGGTCCAGGTC
+
@@BFFDFFDFHHFIJGIIGCHHHIIIJ@EIJIEGEHIIDHJIDHDGEIFGHIDIA'8;3>>>@CC@::-95?BAA59@BBB<288@C@(9>??########
@91H
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFDFFHHGJGIGGGIFJCGGGDGGIFIGGHJDIIJJIBHIIIJFHFHDEFBDDDDCCDDEDDDDECDC@DD<B<?CDCA?<C?C:<BDD959<BB
@91I
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFDFHFGFHGIHIJIIGGGHIHIJFGEI@BGHIJJJJJJJEIJJJCHAH1?BCDDBC@CDEEDCCDEDDDBDD@B<ACCCDDC:ACCDDDBDDBDBD
@91J
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFDHHHHGGIFA@A8EGEIIIIIIIIIIIIIGIIGIIHIIIIIIEEHHFFFDDDDDCDCDACCDDEDAC@<@9B<ACEDDDDC8A:>BBDDDDDDD
@91K
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
B@BDFFFFGHHHHJJIGJJGHHIEIGIIIIJIIEHIHIJIJJJGIJGHHCHCE?DFDDDDDACCFDDCCCCCA:?DDBD<8>@CDDDC?C(599<@BB@BD
@91L
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATNCCGCGCCCTCCC
+
CCCFFFFFHHHHHJIIHGJJJJJIJJ6GHJIJHIJIJJGGIIIIIJJJJHHCHFDF?ADDCCDDDFDDDDEDDDDBB>B?BCCCDDCC#+2?BB<9BBDDD
@91M
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGT
+
CCCFFFFFHHHHHIJIIIHJJJJIIJIGBHHGIIJBGIJJJIJJJJJIJJIJ=CHHHFFFFF@@CEEDDDBDDDD-<002:4>@C################
@91N
CAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCAT
+
CCCFFFFFHHDHHIJJJJJIJIIEHIIIJGIJJJJJJJJJJHHGFFFFDCCCDDDDDD@DDDBDBDCDDDCCDDDBDDDDDDDDDDD@CDDDDDDDDDDDC
@91O
GAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCCCACACCTCAGCACTCTGGGGGGCAGGATG
+
CCCFFFFFGHHFFFGIIIIFIIDHHIIIFIIIJJJGIJJHGHGIIJBBEHHIIG@CF<CACEEHEDEBBDBDDBB@BDDDDCCDDDCDCDDBDDBDDDBCC
@91P
CGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAA
+
CCCFFFFFHGHHHIJJJEIJIJJJIJFHHIJ8GGFHIIFGHIHHHFHDFFFFFFECDDDDDDDDDDDBD@CCDDDDBDDD>CDCCC@8?ADDCCDCCCC<4
@91Q
CCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTC
+
@CCBFDFAHHFHFFHIGIGGIJJFIJFIGGIJGGHG@EHHGBGHJIHEHHFF'3;>ACD:BD=BDDDDCDCD18ACCDDDDCCDD3>BB<?CDDC:@CD>A
@91R
CCCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGG
+
CCCFFFFFHHHHHIJIDHHIJGFGEIJGFHIIJJJHJGGIIJJJJIIHIIHHCHHFFFFD<B>ACC3>CD@DDD@##########################
@91S
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHGHGHIGJJIIFIGIHIIBHGIIJGIEGCHIIJIJJIGIHHEHBEFDDDDDDDDFEDDDDDDCDDDDDD?ACDD<@CCDCCBDDDDBD<??
@91T
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
BC@DDEAFHFHGHJGEEGIIIJIIJJJDGEIIDH98?DHCHIJIIIGD@=AECDFEBCDDC@ADFEDDDDACCDBDBBD?ACCCDBDC<CC<>BDDBDDDB
@91U
CAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGACGG
+
C@CFFFFFHFHFFHIGEFGHEHICHIIJJIGIJJIIIJJJJIGCHIIII@GEHHEFBFCDBBDBC@<A(2:>CCCABBBDDBDBCCDDABB<<5<22(2?>
@91V
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHGADGGIIGEIAGHGIEIIIID<98BEGIIIIIIIIIIFHGHFFFCCBBCCCCEDCC@@DCCCBBC<B<?CCCCBCC?CCBBCCB>BABB
@91W
CCTTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGC
+
BB==BDFFHHHHHJJJJJJIJJJJJIJJJJJJJJFGHIHGIIJJIFEHHGFFFDCDDDDDDDCBDDDDDDDCCCCCACDDB?CCDDDDDDDCCCDDACCD?
@91X
CAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTC
+
CCCFFDDFHGDFHHGGIJ@E4FFHGIEH>HIDIE=3?FHIHIJJJFIIEEFDDDBCCCB2<?BDDDDDBDD3;9@@ADCDDDD7>B?BDDB?#########
@91Y
TCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAG
+
CCCFFFFFHHHHHJJHJJGIJJGHGIJJJIJJIIIJJIIIJIGIJJJJJHHHFFDDBDDDDDDDDDDBDDDDDDC<AADDADDDDDDDCDCBB?CCDDDDC
@91Z
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJJJJIJJJJIJJJJJGGHIIIJJIIJIJJJIJHHFHFFFDDDDDDDDEEDDDDEDDDDDDDD@BDEDDDDDDDCDDDDDDDDDD
@920
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCA
+
CCCFFFFFHGHHHJJIJJJJJJJJJGHGIIIJJHJIGIHHGIIJJIJJJJDHHHHHHHHFDFFEEEEEDDDDB&5)&2>>ACC:@################
@921
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJHIIIIIJJJJJJJJJJJHHHHFFFDDDDDDDDEEDDDDEDDDDDDDDBBDEDDDDDDDDDDDDBDDDDD
@922
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHHHIJJJIJJJJJJJJJIIIJJJJIJIJJJJJJJIJJJJHHHHFFFDDDDDCDDEEDDDDEDDCDDDDD@BDEDDDDDDDDDDDDDDDDDD
@923
TTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCA
+
@BCFFFFFHHFHDGGGIIIIIGGIJJIGICHDHIJIJIIJIJBBHICGGEEFHFBAC>>C>>CDCC>>CACC>@B>>BBDDDC:<(>ACD>>B@B39AB##
@924
TTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCA
+
CCCFFFDEHHHHHJEGFGGIHIJJIJIIJIJ@@GHEGIGIIJJJJGECHFFFH8?9>>BCCCDDFDDDDEDDDDDBDB<?CEDDDCDDDDDDDBBBBDBDC
@925
GGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTG
+
CCCFFFFFHHHHHJIJJJJJJJIJJJJJJJJJJIIGIJJIJIHIJHHEDACEEEDDDBDDDEEEDEEDDDDDDDDDDDBBDDDDDBDDDCDDBDDDDDDDD
@926
CTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGGGTCTCCGCT
+
@C@FFFFFGGFFFFGHHIIGIGHGIGHIIJIFEBHHAEHJFEEEFFBADCA=@28/829:3>;BBB<@:>@CCCD:44:9@####################
@927
TTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGT
+
CCCFFFFFHHHHHJJJJJJJJJHIJJJIJGHIJJIJJJJJHGIIIJJIGIJJJHHHHHHFFFFD@CEDDDDDDDCACDEDDDDDDDB)55:>@AA>C>:44
@928
TCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJHHHHFFFDDDDDDDFEDDDDEDDDDDDDDBDDEDDDDDDDDDDDDDDDDDDDC
@929
CATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGG
+
@@@FFDDFHHGDFGIGIJJJJJGHIFFHGGIJJJJJJJBGIIJGIGGGEHGEHCHHEECFFECED@CD>CCC>?5:ACDDCDDDCDACDDDDA@DDDDBDB
@92A
TGCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTA
+
CCCFFFFFHFFGHIIIIIEAG?C?DBDH?@@DH*?BFF<FFCGGCAGIGEF'.;?CB/;1:CCC;?8>?:@CCCC:?8?AC>:::>>::<(4??(3<AC:4
@92B
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIHIIJJIJHIJIJGIJJJIIJJJJHHHHFFFFFFEEEEEDDDDACDDDCCDDDCCDDEDCDDDDD#########
@92C
TTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTG
+
@C@FFFFFHHFHHJIIJIJHGCGIIIIJFEGIJIJIIGI<CEHIIJGHHEGIIFHHFE@@C?B>@CEEDACCBDD<@CDDDBB>B################
@92D
CCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGG
+
CCCFFFFFHHHHHJJJJJJIJJIHIBEI0?BB?DHAA@@G@CEGGDHG;?EA/<;?ACA==;8='3(3@@C7;-5<>>344(48(2<>::4:A(4>?:@BB
@92E
AAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAG
+
<?@DDDDDFFFDFF<11CEAFF:?EGIDFFIIGIIEF8FEFFFEECEEFF:BB@=>?(>;B>@>(:;,::;?@>B<@BDBBB<4<>A9B99&90?7??BBB
@92F
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGT
+
CCCFFFFFHHGHHJJIJIGIJJJJJJJIGGI@@GGGIIIJJJJJJJJFCHIJ?EHFHFFFFFDEEEDECDDDBD>0904+:@>>C:>>CCC@5<5?@####
@92G
AGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGG
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJGIJJJJJJJJJJJJJIJHHHFFDDDDDDFEDDDDEDDCDDDDDBACEDDDDDDDDDDDDDDDDDDDDDD?
@92H
TCCACGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGAC
+
CC@FFFFFGHHHFHIGHGJDGIHIIIJJIJ>FG@CHIFGIIIIJJIEHHF3AEE;@DEEEEDEDCCC>>ACCDDDCD>>-::@CA:@4@44:>@#######
@92I
AGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGG
+
B@?DFFFFHHHGFIIJIJJJIJIIIIJIJJJBHHIGIIEHIIEIJJIJHHHFFDCECDDEDDDDDEDDD@@9@BB<@CCDDDDDD:@DDDDDDD?BDDBB8
@92J
AGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGG
+
@@@FFFFFDDHHHJE<FFHHIHJGGIJJIJGIDGHFIJJJFDHHIEHIHEEDFDCACDDEDDCCA;@C32=BD>88@DCDB<A?CD@5095>B???A@A8<
@92K
CAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCT
+
CCCFFFFFHGGHFHJIJGJJIJJJIJJJBHJIIGHJIJJHEHFFDDDDDDDDDDDFDDDDDDDDDDD;<B9>;9@29::C-005?:>:@C:@D>A@#####
@92L
GCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGC
+
@CCFFFFFHHHHHJJJJIJIEFHIJJDGIJJJJIEIJJJGIJJJJJIHHHFFDDDECDDFDDDDEDCDB:9>B?AADDCBCCACCBDDBDDDDDDDCDBDD
@92M
TGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJIJJJHHFFDEEEEEEDDDDEDDDDDDDDBDDEDDDDDDDDDDDDDDDDDDDDDDDDDD
@92N
TGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCN
+
@@<DDDDDHHDFHFEGIIIBEHCHEHFGG=BCFGBEHEHIIIEIIIIEEFDDE(>ABCCCD@DCCCB@D5;+8>@@C@CCBCC<>>B>><BD@<@1<?BB#
@92O
GCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJGGIJJJJJJJIIJJJIJJJHHFFDEEEEFFDDDDECCDBBDDD?BCDDDDDDDDDDDDDDD<BDDCDBDD?BB8
@92P
GCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCA
+
;;;A?BA;AD@CAEGIBEC1??FGCAGI<DGHDHB>G@@;CG>=A5:=BB<6ACC:;(-;555;;88;55?B>3::2<C8:@B@@B5>&28<<:8?<<228
@92Q
GCTGAAGGAGGGCCACCGCATGGGCAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCA
+
@@@BDDEDBHDHHIBGHIIE@HG?@FFIGGGHGAFBHA@GHIIIIGDEFFCC>@ADDCCCCCCCABB?0;?ACACCBCCBCCBB><BBCB?BCCBA@BB?0
@92R
TTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTTTCGGTGGGCGGC
+
CCCFFFFFHHHHHIJJJJGIGIIJJJIIJJGGCGIJIIHHIIIJIIJJJIJHHHH@DFFFFEEEDEDDDEDDDDDDDB#######################
@92S
GCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGAGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGGCT
+
<@CDFFFFHGHHFIJJIGEGGIGGIGIIIDFHIJG(?FEGGHGDIEIIJFFCDDABDCDDDA@BBDBDDBDDBB@5ACCCACDDDBDBDDD<?########
@92T
CCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
CCCFFDDEHHHHGIJJJJJJJIIFEFH6@0B>DH0@0AHCGFAFG>GGG;C4==;9B3;?;@B8;,:>>C3955?4:9@@:>?1<8?:AA@>@3:<CCDD#
@92U
CCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGGC
+
CCCFFFFFHHHHHIIIJIJGHIJIIIJJJIFGGIJJJHIIIJIIJJIFIIHHHH@DFFFFEEEDCDDDEDDDDDDDD########################
@92V
TCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCT
+
@@@FDFFDHHGHHGIIIJIGGGGIIGGIIIJJ<FD@DEHBEHIIGFEGIGAEAAHFDF@BDBCCC>C@?;>CAACDCA?A:?CAC@C?BBD##########
@92W
GCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCN
+
@CCFFFFFHHHHHJJJIJJJJJIHIIIJJJJJJIJJJJJJJJIIJJHHFFDEECCEFDDDDEDDDDDDDDBBDEDDDDDDDDBDBDDDDDDDDDDDDDDD#
@92X
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTGTTCTAGGGTCTCAGAGGCGGGGGGCACTCTTCTGTGTTGGGGGGGGG
+
CCCFFFFFHHHHHIJGIFHGGIGHGJJIGHHJGJJEHJJGIGIJJIIGCHGI6-5?CDDDFD>CCCDDDCDDDDB##########################
@92Y
CTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCAC
+
;==DDDAB;:1@DE>:@CAE;;9?C?DDDD:?@?0;C3@=AAC1@ADD8@@6;@;>@>3>>A>>688&)<1>AAA##########################
@92Z
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACCCTTTTCGGTGGACGTCCCG
+
7:=AA1A<+<?188<AA:?94*:=AAA?B>4=AA1=A>BB=887=3;A;A7AAAAA>?;;3;7;>@###################################
@930
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTT
+
CCCFFDD8CFHHH4EGBGIFBHDGIGFEH:@D>FH>GG<GHIIH@FHHGA1=A;CEA>>CD;@>(6==?A?;CCCA@ACCC55@C################
@931
TGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACC
+
?@<DDDDD8DHG?BGFEBGAC>FFGGGCG<>BFGH;=B;FDHIE@4=B8@CCDDCCE;ACAAC3;BDB0<@CCC@?CBCC<@B9><<ABDDC?ADBDBDB<
@932
TGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGACATGCCGCGCCCTCCCAGAGGCCCACC
+
CCCFFFFFHGHHHJJJJJJJJJJJJIIJJIIIIIJJJIIJJIJJJHHFFFCEEEEDCDDEDDDDDDDD@BDEDDDCDDDDDDDDDDDDDDDDBBDDDDDDD
@933
TGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACC
+
CCCFFFFFHHHHHJJJJJJJJJJIJHJJJJJJIJJJJJJGHGIIJHHFFFEEEEFDEDDEDDDDDDDDBBCEDDDCDDDDDDDDDDDDDDDDDDBDDDDDD
@934
CTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTAGGTGGACGTCCCGGTAAGGACACGGTCCCGGTCCTCCCC
+
CCCFFFFFHGHHDHIIIHGIII3CGGIIIIFIEGHIIIIIIIIDB'3=;@@CC@CAA(5@:,5>3>@9@################################
@935
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCA
+
CCCFFFFFHHHHHHJJJJJJJJJJJIHFIGIJJIIJIIGIJGIIJIIJJJ@EHHHHHHHFFFFEEECEDDDD@)5@>A@@@@C##################
@936
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTGTCGGTGGACGTCACGGT
+
CCCFFFFFHHHHHHIJJJJJJJJJJJIJJJJJJGIJJJJJJJJJJHIJJJGHHHHHHHHFFFFCDEEEDDDDB&5)08@CCCC4@################
@937
GCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCT
+
@@@FFDFFHGHHDEFGIGFHIJJEEEEGEFDD;<D>AH0@EG=@C;=7-(6CHFH37ACDFDF>A=6@ACCDDCDA(:<CCC:CB?5<95<>3+:>>@C@C
@938
AAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTT
+
@@CFFFFFHHGHHJJJJJJJGIJJJJJJJJJGJJJJJJJJJJIGHHFFFEFEFEECEECDCD/=@@BBCDDCDDDBCDBDDDDBBAB?CA??BB@BBD<B>
@939
CGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJHIIJJGJFGGIJIGJJJICEGJJJJIIHHHHHGFFFFFFEDDACDDDDCDDDCDDDEDDDDDDDD###########
@93A
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTC
+
CCCFFFFFHHHHHJJJIJIIJIIJJJJIEHIGGFGIJIJJGIGIJIEGGHIFEHHFFFFFFEEDCEACBB5>CDDCCCDDCDDDEDCD@DDD#########
@93B
AATGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTT
+
@B8ADBDFGHHHHJJBHIIIJJJJJIIEIJIIJJGJJJGIHIHEIHHGDFFDFFEFEEEEEBDDDDB<CDDDBDDDDD@DDDDDDBBBDDDBBBBDBDDDC
@93C
AGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTC
+
@@CFFFFDHGHHHIIJJIJFGHGHHIEFDHICGIGGE>FGEIJHHFEFF@DFECCCCCE@BD?=B<ACCCCBDDDCCD@@B<9<B<?DDBDDDB@BBBDD9
@93D
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTC
+
CCCFFFFFHHHHHJJIJJJIIJGIGGIACFDHH<GBDFHGGGGIGIG@EEIHHFFBFDDDDEEEDEDDDD=ACDDC@CDDDCCDEDDDDDDBD########
@93E
GTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAG
+
CCCFFFFFHHHHHJJJJJIFGHHIIGGGGIIJJJIIGGIIJJJHGHIJIIIGGEHGJGIGFGHCD@###################################
@93F
TGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGG
+
@C@FFDDFHGHGDHIDIEHIJJJJ3?DHGD@<CFBFAGG<DHIEEHH3A>BDCBAC?CBBABDD:=B<?CCCB>>BDCCDDDDDDBBDCDCDC@>CCCCCD
@93G
AGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTC
+
@BBFFFFFGGHHHJJGIJJIJJIIJGHIIJGGIEIGIJJJJJDHHFFFCDFFEEDCDEEDDB@?;<ACDDDBDDDCD<B@@BDDDDBDDDDD@@8?@9ACC
@93H
AGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTC
+
@@@DDDDDF7FH?GIGIIIIIECGIIIIIGEHIGI>B=FCHIIHHEEEEEEECCCCDCCCBBB@B?BCDCCBCCBCCB79>@B5?BBC>@8<08<(8<BCC
@93I
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGG
+
CC@FFFFAFHDFFHIGEGGGGIGIJIJJBGGHGGHDHIIFEGGIGIGGCAHH?>>>EEECEB;@ACEEED?<?B@)0&4:>>:(:>:>@:@##########
@93J
AGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTN
+
B@BFFFFFHHHHHHIJJJIJIJIJJJJJJJJJJJJIIJJJJJJFHFFCEFFFEEEEEDEDDDDB;?BDEDDDDDDDDBDBBDDDDDDDDBBDDDBBBDDD#
@93K
GGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCA
+
CCCFFFFFHHHHHJJJJIJIJJJJJJJJIJJJIJJJIJJJJJJHHHFFFFFFFEEEEECDDBDDBDDEDDDDDDCCDDDDDDDDDDCC8ABDDDDDDDDDD
@93L
GGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCA
+
@?<ADADDFHHHHIIIIIIHIGGIG@DDFDGGEGIGGGGIB<BEBA7;BDEFFEEDCEEDDDDD8?CCCCD?:<AC<@DBB>BDDDDCB?BDDD?B<84>A
@93M
GGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACGTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCA
+
@C@FFFFFFHGFFGGIIIGJJIIIJIJJEHIICHGI@GABGII'5?@@DDDEEECEDC@BDBD@?AC@CDDDDDDDDDDDDDDDDDDCDBDDDDBDBDACD
@93N
GAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAA
+
CCCFFFFFHHHHHJJJIJJIJIJJJIJJJJGGGIIGHIJJGIGHHHHHHHGDFFFFFDDBDDDDDDEDDDDDDDDBBDBDDDDBDDDDDDB8<BDBBCDDC
@93O
GAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAA
+
CCCFFFFFHHHGHJJJIJJJJIJJJIJIJJIJJIJJJIJIHJJJHHHHHHHFFFFFFEDDBDDDBDDDDDDDDDDDDDBDDDDDDDDDDDDDDDDDDDDD>
@93P
AGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAG
+
=1:1=ADAHAFHGEGGHGGGHIIGGIGGIIIIGIIJDI:;AGGG@CHEHHHHF@@?;/=98/59@:@>@DCDC+9<BDDDDBBDCA188???<@BACCDD3
@93Q
GGCTTGCACAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGG
+
@@@FFFF+ACFDFHGHG>ECFECBFHIIIIICGGGHGIIIGIIIIHGGHHHGHIIIIIIIIG>CGGHH<AEBFBBB<CCE@CCCDDCCCDDCCCCCABBB7
@93R
GGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGC
+
@@@FFFFFFFHHGJHIIIGIIJIIJJJJJJIIGEGJJIBGIG>EHJHGHGHHEE;??>>:@@ACACCDCABDDBDBBDDBDDBD>A?<<?BBD@B>ACCCC
@93S
CTGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCA
+
CCCFFFFFHHHHHIJHHIJJJJIJJJIDIGGJJIIGHIHJJJJJJJJJJJGHIIHGFHHHFFFFFDEEDDDB;&55:@C@A####################
@93T
GGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCA
+
BC@FFFFFGHHHHJIIJJJJHHBIJIJJJIJGIGIEGIJIIIEHEHJHHGHHHHFFEABD<ADEDDDDDDDDDDDDDDBDDDDDBDB7?BDD@BDDCDCD@
@93U
CTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJHIJJJJJJJIJJJJJJIIGIHIJJIGGGIHIIJIHHHHHEFFEFFCEDCEDDDDEDDABDDDECCDDDDDDDCD
@93V
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTTTTTGTTGGTGGGGGN
+
BB@FFFFFHHHHGJJIJJJJJJJJJJJJIJJJJIJJJJIJJJJJJJJJJJJJCHHHHFFFFFFCEEEEEDDDDD###########################
@93W
CTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTG
+
@@@DDDEDGHHFHIJJIJIJJGIGIIFHIIGHCHIJIIDGGIDHDHIGHIIIIJJJJEEHFFFDCBCFCCCB@A;@@CDDDDDDDDCB@?CA?BB>>?@<?
@93X
GCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAG
+
@@@DFFDFAFFFDEGGI<D@FBHGAGGBB9D>>@@7AHGECCC4CGGHEEH>3?=>?B@895(,:(5>?CC;95&0<BABB?A(+880<<?>AC?3@CCB?
@93Y
GCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJIJJJJJJJJJIHIJJJJJHHHHHHFFDDDDDDEDDDDDDDD>B>BDDDDDDDDDDBDDDDDDDDDDDDDD#
@93Z
CCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJIJJJIHIJJJJJJJHHHHHFDDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
@940
CCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGN
+
BCCFFFFFHHHHHJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFDDDDDDEDDDDDDDDDDBDDDDDDDDDDDDDDDDDDDDDDDDDDD#
@941
CTCCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCT
+
CCCFFFFFHHHHHJIIJJJJJIIIJJIJJJJJJJIHIJIJJIJJJJJJJJEHHHDCDB?CDCCBDDDCD=BD;>B<A?DCCBD?BBDDDDBCDDCDCDDDA
@942
CACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJHJIJHJJJJJIJJIIHHHFFCD?ACECDBDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDA
@943
ACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTG
+
@BBFFFFFHGHFHIGIFFIJJJIJJJJJIIIIGIJIIICGHIJIIJJIJI>EEFDDBBCDDDDDCADDB@>@5;5?B@DDDDDBDB?BB?CDDAACDCDAC
@944
CTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGG
+
CCCFFFFDHHHHHJJIJIJJHHJJJJJJJJIJJIJJIIJIEIGIIGGHHGIIGDHJJHI=AEEFHFEFEFDDDEEDC;A@CCDCCDCDDCCCCCB??BAAC
@945
CGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJJIJJJIJHFDACEEDDDDDDDDDDDDDCDDD@DDDDDDDDDDDDDDCCDDDDDDDD?
@946
CTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGG
+
@@@DFFFFHHFHHJDGHIJGGFHIJIIIIIJEDFGHJJIJGIIIJHGIIJIHHHHH@CFEFECECDEDCCDDCDD?@B#######################
@947
TCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTG
+
CCCFFFFFHHHHHJJJJJJJJHIJJJJJJJIJJJJJJGGGHCGIJJIIGIIJJJJJIJJJEHHEHHFFFFED?CEACDABDDDECDDDDDCDDCCBDCD##
@948
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACTCTTCTGTGGCGGTGGGCGT
+
@@@DDDDDFDFDFFI:?:?EFF@@FFFIDGFFIIIIIFIIIIIICFFECEFIFFFFFFDDDD?AACBCCBBBBBB39&55?####################
@949
CGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGTGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGT
+
@CCFFFFFFHHGFIJJJJJJJJJJJIIJIJHIIJGIGGGGHIGIJJJIJJIGDDA@CDDABDDBD@:',8?CCBBBDDBDDDDD?8>BCDDDDD@CBDDD?
@94A
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGT
+
@@@DDFDFHHDFHDEHHDAGGI0CFHIGHIJIIIJJGIGCHHGGIHDCHGII>EEFFFFB@B7>AAAC#################################
@94B
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGT
+
CCCFFFFFHHHHHIJGJFGIJJIJIJJIHIGIIJGFIGHIGGJIIJJJIJJJEHHHHFFFFFFEEEDEEDDDDD@##########################
@94C
GCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTG
+
CCCFFFFFHHHHHJJJJJJJIJIJJJJJJJIJJJJJGIJJJJJJJJJIJIHFFDEEEEDDDCDDDDDDDDDBDDDCCBBDDDDDDDBDDCDDDDC?CCCCD
@94D
GCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTG
+
CCCFFFFFHHHGHJJJJJIJJJJJJJJJJJIIJIJGGGIJJJJJJJJIJJHFFCBEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCD
@94E
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTTTTGGTGGGCGTCACG
+
CCCFFFFFHFDHHGJJJHFFBHGIIIIDFEGHFIIJIIIJJEGHIJIEIIGH=?CHHFEDDFBECCEECDBDDDD##########################
@94F
CATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGG
+
CCCFFFFFHHHHHJJJJJJJJIJIJJJJHHIJJJIIJIJJIJJJJJIIHHFFDEEEEEDDDDDDDDDDDDDDDBDAABDDDDDDDDDDDDDDDDBDCC<CB
@94G
CATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGG
+
CCCFFFFFHHHHHJJJIJJIHHJJJJJJHIIJIIIJJJJJJJJJIGIJGHFFDEEEEEDDDBDDBDBDBDDDDDDDBDDDDDDDDDDDDDDDDDDDDDCCB
@94H
CATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGG
+
???DDDDDDD+AAEEI8C??EAECEDIIAADD<DECEECCDA=BA74A8:?<5;@>>>??>?AA88=;?;>><<?:>>>>>0229>AA:(4(8><AA?<?<
@94I
CATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGG
+
@@@DDDDDHBHHHIIIIDHC;ECH?GIIGGIIIIFFIIGGEGGHAHHGIHEBAACDCCBC@@CA;;8;3;B?BB<C?BBBB@8@@?CC@CCCBC??A<<<?
@94J
GCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGC
+
CCCFFFFFHHHHHJJJJJIJJJHIIJIIICHJJJGIJJHIJJJHFDCEEFEEDDDDDDDDDBBBDDDDD?CDDDDDDDDDDEEEDEEDDDDDDDDDDDAD@
@94K
CGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTC
+
CCCFFFFFHHHHHJJJJJJJJJJJIIJJJJGIDGIIJGIIJJIGGIIIJIIJHHHHHHFFFFFFEDDACDDDDDDDDDDDDEDDDDDDDD5<5::>@CCC:
@94L
TTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGT
+
BCBFDEFFHHHHHJJJJJIJJJFHGIIIJGHIJGIJJJJIIJJIIJJIIJJJJHHHHGHFFFFDAEEEDDDDDDDCDDEDCDDDBDB##############
@94M
CATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGG
+
@@@DD?DDDFA<CGIBGIIFFIIIIII:FGEGIF?BFFIIICFFIBF/AEB<5;;AAA?3ABB@BBB5;BBBBBBBB?<<B@BB9<>?A3@A?BBBB@39?
@94N
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGAGTGCATCTTGTCGGAGGACGGCACC
+
@@@=DDDDFAADHGE<??EGGIGIDGIG>;4?**B?DB8CF=DAAGCHGIFI6=EEECB?@D?ACCA@CC?B@############################
@94O
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
CCCFFFFFHFHGFIIGIEGGIJBHIJJJJGJJGIJGGHGIJIJIIJGIHGDFDBCCDDDDDDDDCDDDDDDBDDDDDDDDCDDDDDDDACDDDDDDCDACC
@94P
TCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGCGGCGCCCT
+
@?@DDADDHAHFFIGGEG?@D>DF:E81?@DGHH;DFEHG>GBH>HI@@@)5=6=ABD@D;?;@@;>11,55@5>>>:(5:9ADCCABBB@##########
@94Q
CTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGC
+
@B@FFFFFHHHGGIJJJJJIGGIGIGIJIJJIIIEIIIGIJJEGEIDHHHHFFFFDC?@BDDDDDCBABDDDDDBBDDDB@<BDDEDDDDDDDDBDB@<?>
@94R
ATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGA
+
CCCFFFFFHHHHHIJJJJIGEGEGHHGGIIIJJGGIEGGGJJGIIIIEGHFBCEDEEDDCDCD@BDBDDDDDDDDDDBD??BD@DDCDDDDDDCDDDDDD<
@94S
CAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGG
+
CCCFFFDDHHHHHJJIIJHGIJJJHIIJIJJJJJJJJJJJJIJJJIIIJGH=ABDDDDDDDDDDDDDDDDDDDDBADDBDDDBDDDDDDDDD?BBCDDD9?
@94T
TGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGGG
+
@CCDFFFDFGHHGJGJGIJJJJIJFGIIJJJDGIJEGGIIJJJJD4AAHFEFCCCECDDDDDDBDDDDDDDBCABBDDB@B<<BDD@CDDDDDCDDCC###
@94U
TGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAG
+
;@?DADDA=BFFFIBGIBDGDEHIGHFGHGGIBFHEGGCCFBHI@FGG/?5?>;CACC@?>CB68>@@@B@@<ABA7??<@BB<C?>@:@??B9><?AB<<
@94V
GCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGTTT
+
CCCFFFFFHGFHHIJJJAFIIHGG;FCGHGIIGHGIGIJJIBDHIBCDHIIHIJIEHEGIGFB@#####################################
@94W
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCA
+
C@CFFFFFFHHHHGIGHGJIIIJIJJGIHGIJIGHIIIJIJHIHIHHIJJ@GEHHFHHH;@CDCDEEEDDDDD095@@CCC>CCCC@@(:>B#########
@94X
GCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGA
+
CCCFFFFFHHHHHJJHIJJJJJGIJJJCIJIJJJI?FHIFHIGHHFFFFECCDBBBCCEEEDEEDDDDDDDDDDBDBDBD@B??@CDDDB>B@CCDCCA?2
@94Y
GGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
;@@FFFFDGHFHHIJIIGIJJIIJGDDHIFIGIIGIIJFIHIJJJJIGB???CCCCEA2;@@@?BBBBD@BDCDA<??BDDD@CCCDCC89ACCA?CBBBB
@94Z
GGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
CC@FFFFFHHHHHJJJJJJJJJIJIJJJJJJHIJIJJJJJJJJJJJJFFFFFFEEDEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCDBDD@
@950
GGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
CCCFFFFFHHHHHJJJJJJIIJJIJJIIJJJJJJJJGIJJJJJJJJJHFFEFFEEDEEDDDDDDDDDDDDDCD@BDDDDDDBDDDDDDDDDDDDDCDDDDD
@951
TGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAAC
+
B@BFFFFFHHHHHGIJJJJJJJJJJJHJJJJJJJEHIJIJIJJFGFHIJJGICHIIIIJIIEE>CAHEFDCFFCECCCBDCDCCDDCDECCA?@CCDCCDD
@952
GGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
CC@FFFFFHHHHHJJJJJIJJJJJJJJJJJJHJJJJJIJJIIJJJJJHFDFFEEEDEEDDDDDDDDDDDDDDDBBDDDD?DDDDDDDDDDDDDDDDDDDDB
@953
GGACAAGCCCGCCAACTGCCCACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
CCCFFFFFGHHHHJJJJJJ*:CGHJJJJJJJJJJJJIIJJIJJJJJJGFFFFEEEDEDDDDBDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCD?BD
@954
GGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
@CCDDFFFHHHDHI@FGEGIII)?FHAHHGIFGHIIIIGIIHDBH<AHF;@DEE=ACECC@?=@B@B>???CCABBBBBBBBB>CCCCCBCBCCA9??BA<
@955
GGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGG
+
BB@FFFFFHHHFAFHIJIJHHIGIJIGIIIIHIIIIHCGHGII>GHIHE?DDFCEDECBDCD:B=B>>BD@AC<A@B?@DDDDDDDCCCDDDCCCCDB?A<
@956
CAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCACCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCT
+
CCCFFDFFGHHHFIIJJJJJIIEGGIJJIGICCCH>@GIHCHEFD?9A@BDDB@C>(,+8ABDDDDDD?@B;BD<(3:CC@DBDDDD::@CDEDDCCB@B<
@957
CTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGG
+
CCCFFFFEHHHHHIIJJJJIJJIJJJJHHIJJJJJIGIJIJJJBGHIIIJJJJGIIIJJJIGEHHFHF@CFB>>=>AB?CCDDCABCDDD@CDCCDDCCA?
@958
GACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGN
+
CCCFFFFFHGHHHJJJJJJIJJJJJIJJJJJIJJJJJJJJJJJJIJHHBDFFFEDEECDD@BBDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDCCD@BB#
@959
AGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTG
+
CCCFFFFFHHHHHIJJJJJIJGIIJJIJJJJJJIJJJJJIJJIJEHHHHFFFFFEEDDDDDDDDDDDDDDDDDDDBDDDDCDDDDDDDDDCCD?AD?BDDC
@95A
CGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGT
+
CCCFFFFFHHHHHJJJJJGIJJJIJJJJIJJJJJJJJIIHGHFFF9=ABDB@B8?>CCDB<;?:@A3>>(>:@@@-9?@BB02895999(3:>C#######
@95B
CAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCCCACACCTCAGCACTCTGGGGGGCAGGA
+
CC@FFFFFHHGHHIIJJJJJFIJIIJJJJFHHIGIHIIJJIJJEIIIJJIJIIJJJJHIGJJGGGGFDEFDCDBB@BDDDDDDDDDDDDDDCDDDBBDDDB
@95C
CACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCG
+
@@8;DDBDHFDHBGHIIIIHIGIIIGIIIEEFFHGIIII'=EFFFFB?BDBDDDDD<?@BDDDDDDDBBDDDDDDB((28A?BDDDD><9<>BBCDACCDB
@95D
CCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGA
+
C@CDFFFFHGHHDIIIJHIJJJGHHIIIIIGJIGGGBHGGHI;@D@GGHHHHFFEDDDB68<@DCAB@BDDDDDDDDDDDDDDDDC@C9ABDDDDDBCCDD
@95E
CCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGA
+
CCCFDDFFHHHHGIJJIJJGHGIJGIBGIGGIIGGFCFGIGHEHICHGEHEACDFDD?;BBBBBCCBDBDBB8?@ACCCCCCDDDCC<39?8A?<??C928
@95F
CAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCT
+
BBCFFFFFHHGGFIJIJJJJJJJJJJJJJJJJHEHGIIIHHHFFFDDDDDDBDDDFCDDDDDDDBDDDBDDDBBBBCACDDB9><@@CDDDDDCDDC5<?8
@95G
CCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGAC
+
CCCFFFFFHHHHHJJJJJIJJJJIJJIJJJIJJJJJJJJJIHIJIJJJHHHHHFFDDDDDDDDDDDDDDDDDDDD@CDCDDDDDDDDDDDDDBBBDDDDDA
@95H
GGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCCCACACCTCAGCACTCTGGGGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJGIJIJJIJIJJIJJJJJJIJJJHIJIJJDIJJJJJJJJHHHHDFFFDDCDDDDDDDDDDDDDDDDDDDDDDDDD
@95I
CACGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGG
+
CCCFFFFFHGHGHJJIJHIIIJIIJJJIFHIJIJJIJJJJIJIJJJJIJJHHEHFFFFFFFDEEEEEDDDDDDDD##########################
@95J
CCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJIJJJJJJHHIJJJJHHHHHFFDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDCDDDDDDDDDDDDD
@95K
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTT
+
CCCFFFFFHHHHHJJJJJJJJIJJJJGGHIJEH@HGGIEHIIJJHGIJJGGHEHGHHFFFFFFCEEDDBDDDDDDCCDCDCCEDDDDDDB###########
@95L
GCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCC
+
CCCFFFFBFHHHHHIJJJJHIIJJJJJJJJIJJIJJJJJJ@EDFFFFDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCBBD>>BDDDDDD
@95M
GCCTTTTGCTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATC
+
B@<DFFFFFHHHHGHIIIIJIIIHHGGCHHIGGIIHGGFIGEHHH<FH:AG;7@;?=>>@EECDFEDEA@>;?@B/2)58993A>AC>3:@<?########
@95N
GTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCCT
+
???DDDDDDADDDI)?6??B8=BC@B7.8=7ACCAC>@CC)=ADADAD6;A@;AAAA=;,;=:=5<>>+9><>89884:8<<>3>AA>>::9(2329<?##
@95O
GGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTG
+
CCCFFFFAFCCD>GFHI>GGGGG<G6DF>BFGIFFGIBH@=B(:ED?ACECCCCCDD@(1;@;8@BBB;B@CCDD@BDB<CC3:>CD:::A>9<?@D<@A@
@95P
GCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGC
+
CCCFFFFFHHGHGGJJJJIJJJJJJJJJJJECHIIIIJJJIIJJJIJHFFDECEEDDDDBDDDDD??@>BBDDCDACCDDDDDDDB<<?BDBDD<?CCDDD
@95Q
GGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCT
+
@B@FFFFFFHHHHIHIGIJIJIGJJIJJJBGGIIJJJHHHFFCDDBBDBDDDBDBDDDDDDDDDDDDDDD8AAA?<A?BBD<<<>@CDDCDD@BBDBCCDD
@95R
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
?@@BDDDDADHHDEIEG6@CFGIG>FH<?CHHI?*00.7'-@;FG@H@@==C=D<B?BB?889A<B<0<888;<C?44:48<8(49?CB???BB@??<???
@95S
TGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATT
+
CCCFFFFFHHHHHJJJJJJJJGHJJJJJJJJJHHFFDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBD>BBCDDDDDDDDDDDDDDDDCDDDDDDD
@95T
CTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGG
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIGIJJJIJJJJIIIJJJIJIIJJJJIJJIJJJJIIHHHGHCFFFFFEEDCEDDDDEDDDDACCECCDCDD>CCCC
@95U
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
B@1BDDFFGHHFHIJJGHIJJJJJJIJGIGIIJJIGHI@GCFGHHECHGGHHHFCDDDDDDDDDDDDBDDDDBDDCCDDDDDDCCC<CDD?B?ABAC@BD?
@95V
CTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGGTTTCCTCCACGGCTTGCTCCGGGCTGCCA
+
CCCFFFFFHGHHHJEGGJJJIJJJIIJJJJJJJGJJI':,7.7)76@;66;>@;@CC5>;:(:,:<@AC5?(8<@##########################
@95W
GCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGG
+
CCCFDFDEHHHGHIIIEFFHIGHIEHEFFGGCFHE?BBEH@GCHHGIGFEHFDCEFCEDD>ABCCDCCDDDCCCCBD9?CDCDCCCDCDDDDDDDDDBDB5
@95X
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
C@@FFFDDFFHFHGGGGGHGICEGGGIECGEGIGHIJG@B;@DHECGEECEEEFC@B?BBDDDCD??<@@?B;BDCCACCDCBCCC??BB???BDDDDDD<
@95Y
CCCAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCG
+
C@@FFFDDHHHGHHIJJGHHGIJJGIIIGHGIIGIGHJJ8BCFEFF?BCDDDDD=:?@B@BDDDBDDDDD@@@@DABBDDDD?A?ACCA@<BBBDCDDDD<
@95Z
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
C@CFFDFFHHHGGJIJJ>GIJJGHIJJJCHGIIIJGGJFI;CHGHIJGI>CHHECDDDDDDDDDDDDDDDDDDDDDDDDCDDDCDD3?B?BD?BDDDDDD<
@960
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
CCCFFFFFHHHHHJJJJJJJJJIJJJJJJJJJJJIJJJJJFHIIJIJJJJHHHFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDC
@961
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACG
+
@@CFDDFFGHHHHIIGI8GIIIGIGGIJJGHIIII6FEAH@FGEIIJJGIHGHFDDBDDDDDDCB?BBDDBBBBCD3@CDDDDDDDACDBBD(8??C8<B#
@962
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
?@@FFFDF8CFHFGGB@AEH>FDGFHFHHGIGIGI6@FF@@FEFCCAAHG<E=BCB>8=B@BCCC9+<8<<<;?:ACCCA<CA9A?C30+88<2<C#####
@963
CTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTG
+
@@@FFFFFHAHFABH7GHHEIIHIJIJAH@@9DGAFFIGEHIIII>G@BBGGIJGHFHHHHGIGHC=E@HGFD@BFCCA@@CDCCCCCCCCDDDBDB@BD>
@964
GCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGT
+
CCCFFFFFGHHHFGGHH@HIIIJJIHIG>HHIIJJDEHGGBGIIIGII?<7;CGGFEIIFHFFDECEDECCCDC>?BBC9<B:<:?B@C@C:(8@AAC3?<
@965
GGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCT
+
BC@DFFFFHGHHHJJJIICGGEHJJJJDGAHIII;@EFHFFFADBD?B@BDDD<<<@BDDDDD<8A8ABBBDDDC8ACA9@59@>CCCDC5>9@B<1<<A@
@966
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATNCCGCGCACTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
CCCFFAFFHHFHGIJJJGGHIIBBGIGIIJJJJGDHEIIJHHJJJIGGI#-;CDFD'3;CCDCCDBBBDDDDBDDDCDDDBDDDDDCD?ABBBBBCDDBD<
@967
GGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGC
+
@C7DFFFFHGHGFJJJJIGEGGJAEC@FGEBHIIJCFGIIJDDFHHDFHBHGIJEGGGECGDFGHEA?35<CCDBDBD@DB<95<B@DDDDBA@BD1(99@
@968
GTGCCCTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGA
+
@C@DFDFDHHDH?HCGHIAEEHIEEGGG<FEH9DHIGIIIJIJGHIEBFHIEC3BG:@G'==<EBBDCA9>=?BCCC(5>C:(<<CCDDBA3:@C@CC@A@
@969
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
CCCFFFFFHGHHGJJJJ<GHIJHGJCIIHGHIJJCGHGFECGGIIJJAAEEHHFDDB@BDDDDD<9?BDDB?BB@C>CCDDCBCCC<?@DDDDDDC?2<A<
@96A
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCG
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJJJJJJJJJJJJJJIIJJJJJJJJJHHFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDBDDDDDDDB
@96B
GCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTG
+
CCCFFFFFHHHHHJJJJJJJDHIJJJJJJJJJHFFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDBDB@@BCDCDDDDD<BDDDDDDDDCDDDDCDC
@96C
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCG
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJJJJJJJJJJJJIIIGJJIGIGJJHHFDDDDDDDDDDDDDDDDDDDDDD:ACDDDDDDDCDBDDBBDDDDDBDD
@96D
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
@@@DDDDDHHHHDFH:C?DEDH@D@GI<?BFH?DH@FFDAGGEGI@=@B8B4=5>A>C@@=@BA;55>>A?288?:>@>@>>:9@CBB2>?CAC34AB399
@96E
GTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCA
+
CCCFFFFFHHHHHJGIIJIJJJJJIJJIIDIJ?FGHFHIIJIJJBFHGIJFHIJJJHIIHHHHHHFFFFFEEDDDDD<BDDCCDDDDDDDDDDDDBD@DDB
@96F
CCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCAC
+
CCCFFFFFHHHHHJJJJJJJIJJIJJJJIGIJFGIDGGHGIJIHHHHFFD<@@CCCCDDDDDDDDDDDDDDCCDDDCDCDDDDBDBBBDDD3<B?CDBDA@
@96G
CTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGGGCTCCTCCGCAGGCTTCCTTAG
+
@@@FF=ADFFFBBFHHIIIIIIIIGH@AFGGDGEIHGHFAA?@?@DDDB@??<BDDDDB@?@DD8??A8???8<AA><&09@DDDDD>B75<>??CCDD@A
@96H
GCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTT
+
CCCFFFFFHHHGGJIJJIJJJJJJIJJJJJJIJJJJJJIEEHGFFFDDA?@BB:B5>:@C7@57B>>:ACA@C>@@>&5??>@##################
@96I
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCA
+
@@@FFDFFFHHGGJIJIIED:FGHIJDFIB9AH?DGBD<FFGGIJIHCGH=CEEHHHFE?CDFE;A@CA?BBB&&)+4>::>@A>>A:@############
@96J
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCG
+
CC?DFFFFHHHHFJJJJIJJIIIJIJJJJJJIHGJDIIJIIIJJJIJJJJGEEEDDDDDDBCDDDDDDDDDDB@C@@CDBCBCCCAC@8ABBBBCDDDDCB
@96K
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCG
+
CC@FFDFFHGHFGJJJHJJJJGGHEIGGIIGBHGGGGIIBBDH9FHHGIJHHA==BDDDDDD>A9??@B@D9ACD@@CDDCDCCDCDDDB0+<AC???BC@
@96L
CGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGGCTCCGCTTTGCATTCTTCCTCGGCTCCCTGCGGGGTCTCCGCCTTGTGC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJJIJJJJJHE:9B'9',55<88';?333:A::@################################
@96M
GCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCG
+
CCCFFFFFHHHHHJJJJIJJJIJJJJJJJJJJJJJJJIJGIJIJJIIJJJIHGFDDDDDDDDDDDDBDDDDDDDDDDDDDDDDDDCCD@DDBDDDDBDBAB
@96N
AGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTC
+
@CCFFEFFHHHHHIJJIFIIIGHIJJJJJIJAHGJJJHGHFFFDDDDDDDDDDDBB?BBBDDDDDBDDDBDBDBDCDDCAA9@>58ACDDDDDB3<B@BDD
@96O
ATGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTG
+
CCCFFFFFHHHHHJJJJJJJJHJJJJJJIJJJJJJJJJJHHIJJJJJIJJJJJHHHHHFFFFFCCEEEDDCDDDDCDEDDDDDDDD&5)4>@4:>A#####
@96P
CCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGN
+
CCCFFFEFHHHHGJIJJJJJJJJJJIJJJJJJJIJJJIIHIGIIJJIJJJIGBDDDDDDDDDBDDDDDDDDDDDDDDDDDDDDD?CDDDD@DDCDDDDCB#
@96Q
CAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTG
+
CCCFFFFFHHHHHJIJJJJHHJJIJJJJJJIJJJIJJCHIIGIJIIJJJIHFDCDDDDDDDDDBDDDDDDDDDDDDDDDDDDDADDDDDDDDDDDDDDB5A
@96R
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTGACTCCTTTGTGTCGGTGGACGT
+
??<?DDDF?HDFDEBFDFAC>GHI@DEEBDGGC91/?B8=BCF@E)==.=A@..=AED@BDBDCCCACEC?B#############################
@96S
CAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTG
+
CCCFFFFFHGHHHJGIJJJIIJJJJJIJJJIJIIJIJBGHIJJICHIJJJHFDDBDDDDDDDDDDDBB@BDDDCDCAA?BDDC<ADDDDDDDCDDBDDDBD
@96T
CAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTG
+
CCCFFFFFHGGFHHGGIGIE9FGGIJJHIJJJBGHGIGGHIJGGIGIGJBBBACDBDDDDDBBDDBDDDDBCCD3>CDC?CCD?CDBDDBBDCCDDDDDDD
@96U
TTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGG
+
CCCFFFFDHGHHGJJJGGGIJJEHJGIJJJJJIGGGIJJ<;CGHJJJ7CEGEHD>ECB?BFEEE>AA@CCDDECDCBD>B-)50:3>::(44@:A######
@96V
TCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTG
+
CCCFFFFFHHHHHJJIJJIJIJJJJJJJIIIJFGIIIJJJIJJJJJIJJJJJHFHGFBCFFEBEEEDCDDDDDDDDBBDB)504>AAAACCC:@:A><B58
@96W
CTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCC
+
CCCFFFFFHHHHHJJJJJJJJFIJJJJJJJIIBH;DGIIJIJIIHJEEHFDDDDDDDDDDBDDDDDB?CDDCDDDDBDDD9?BAAB?BBDCBDDDD<BBDA
@96X
CGTTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGGCTTC
+
@@@DDDDDHHHHHIIIIIHHAFH0@09<?F::(?F4==FH8=@7==@@E?;=C'.;89>'85::5@==-9?449(3(:?+<8?:>>:A:((+::??&05A#
@96Y
CGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGC
+
CCCFFFDAFFFHHIJJJJJJJJJGIJIHHIHIJIIIIIJJJJJFGIJJDHCFEHFFFFDDDDDDBB?CCDDDDDDDDDDDDBBDBADDDDD<A@BBBD@BD
@96Z
GCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTTCGGAGTCTCCGCTTT
+
?@@FDFFDDHGHHIIJJJIJGIIIDHIHIIJGIIIJIIJIHEHFFFDAA@B388=(3:>C7@3;@3(+4@:@A>:44&0<<5@##################
@970
TGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTC
+
B@@DDFFFHHHHFIGJHIIJJJJIGHJJGIJIHIJJJJJJGEGHGIIHHFHGFFF@CEEEBDDDDDDDDDD<BDD?>BDAA@BDDDBDDDECADDCBBDDB
@971
CTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACCC
+
CCCFFFFDHHGHHIIJIIIII@FGIJJGEGHIIHIAFDHIIHHGGIGHGGDEEFHBCDCDDCCCEE@CBD5;C:A@@CDD???CDCDCB?BD#########
@972
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTT
+
;?@DADDDDHDFCD@GFB9@3:?@F:??E0@@<)9?FEGAHGG@@GG)).5==6=7=;@D@:>A(6;=;5;5@C:,5<?33>AC:>8?B############
@973
GCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTT
+
CCCFFFFFHHHHHJJIIIJIJJIJJJJJIIHIIIIIJIJJIJJJJJGFFDDDDDDDBDDDDDDDBBCDCDDDDDDDDD??@DDD@@AC9A@DDB@ABDCCC
@974
GCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTT
+
CCCFFFFFHHHHHJIIJJJJJJJJHJJJIJGIBFHIIJIJGGIJBHHFFDDDDDDDDDDBBBDDDDCDDDCDDDDDDD?CDDDDD@DCDDB??>9A?BCDC
@975
GGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGG
+
CC@FFFFFHHGHHIIHJIIIIJJJFHIIIIDGHGIJIJJGGIFG;CGDHHFFDEEDACCCDEDDDDDDDEDCCD<ACCCACCDDDDDDDCC@BB.0?BDDC
@976
GCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTT
+
@C@DBDFFH?HHHIEGIJJIGIIGGIIJJJGGDGIIGGHGICHGEHEFFDDDDDDD@BBBDDDD>ADDDDDDDDDACC9ADBDD@BDDCDD@CDDDABDDD
@977
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGT
+
B@@DFDFFHACFHEEHIHIIIJJJIJHGDHIIIIIJIJEIIHIJGHJIIIIJAHHHGFDFFFCEEEDC@C@DDDB055(4>AC:A@A##############
@978
GCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTT
+
CCCFFFFDHHHHHJHIGGJJJIJIIIJIJJGIFEHIJJJIJIIIJIFFFDDDDDCDDDDDDDDDDDDDACDDDDDCCCCDD?B@DBACDDDDDBBBDDDC>
@979
GCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTT
+
CC@FFFFFGHHHAHFHJIJIAHIIJGGIJGIJ1BFBHECHIIGIFBHFFDDDDDDDDBDDDDDDDDDD<AC(<?AACCCCDDBBBBBA<A8ADB<AB?>>:
@97A
GCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTT
+
CCCFFFFFHGHHHJIHGGGIGIJBGHDHIGGJGHGJIIFJJGGIIJHFBBDDDDCDB?DDBDDDDDDCD>CDBCDCCDCCDDDB@B<C9?AB9@BB?BDDD
@97B
GAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGA
+
@BBDFADDFH?FFHIIJJGIJIIIGJJGGIGIIHGGGIIIIIII>GDFHHGIBFHIIIJGDHHGGGHG7.;;5;?<?B;88=BBB83>::@4@:9>@DDDC
@97C
CTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCC
+
C@CFFFFDHHHHHIGJJIJIJJIHGHIJJJJEHJIIJJJJJIJJJJJJIJJIJJJIJHIIIGIJIIIHHHFHHHFFFFCDDDDDDDDDDBD>?B?BDDDBD
@97D
CCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTN
+
@BCFFFFFHHHHHJIJJJIIJJJJJJJJJJJJJJJJJJJJJHHHHFFFDCEEEEDEEDDDD@BDDDDDDBDDDDDDDDDCDDDDDDCDDDDDDDDDDCDD#
@97E
CACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTA
+
CCCFFFFFGHHHHIJJJJJJJJJJJJJJJJJBFHIJJIJIIJJIJHHFFDDDDDDCDDDDDDDDDDDDDDDDDDDCDCDDDDDBDDDDDDDDDDDABDCDD
@97F
CACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTA
+
CC@FFFFDDHGHHHGIGIIJJGHF?EB@DFH8BE*9@@FEGGD@8EEEFDDDDC@AB??<@?<@BDCACCCB?BDCC398??B0<B?CDDBCB5?<2@:A>
@97G
TTTTGTCCCAGTCGAGGTGGTAAGAGCCCCGAGAAGCTGGCATGGGGGGGTCCTCTCCTGCTCCGCTCCTACCGTCGTCCTCCTCCACCTCCTGCGGGGCC
+
CCCFFFFFGFHHGIGGG)AF@HHGEI<FGGEH<DF@FGEDCHEIIJJJDB07?>CD?CDCDC>@-8;>89AD?;B><9??@CC399(3<AA##########
@97H
CACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACC
+
@?@BDD<:DF?D?GBFB:CE4CEB@)??0)9?BFFEFDFF3@F@BB'9?CC>@92((558@@B<5>@+4?91>A9?<?#######################
@97I
CCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAG
+
CC@FFFFFHHFCFGIIGEGDHHJIGGIJIGIIIIJFHGJJFIIJJJJJJCEIFEHHFFFFDDC>CCC@CDD;?BDB50)4:>(44>::>A@##########
@97J
CACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACC
+
CCCFFFDDHAHHHJJJJJJJIJIIJJIJIDFHJJJIIJJJHHIIHHFFFDDDEDDBBDDDDDBCDDDDDDDDCDDDCB@DDDDACDDDDDDBD?ACDDDDA
@97K
CGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGGC
+
CCCFFFFFHHHHHJJJJJJJJHHEEH6F8BDDH:@:FH=<=@F4=F=@@@8BCEBE66;>>B8=,5>>C9>9>B:><:>:>@(8<A@@AAC>>@3+4?B##
@97L
GTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTG
+
BCCFFFFFHHHHHJGIIIJJJJJJJJIGIGGIIIGGJJIJIIIJJJJGIDGJJJJJJJCCAEDDCDDFDCEDDDA=@<CDDB?5>?@@?B8?@BDDBBDBC
@97M
CACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCG
+
CCCFFFBDHHHHDGIIIJFHHIHJJIJJIIJGDGIJGGI;AEEFDECDDDDDDDDDDDDDD?BBBDBBDDDDDDDDDDBDDDDDCDCCBBD9<?CCDCCDB
@97N
CACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACC
+
CCCFFDDFHHHFHIJJIEIJJJIJJIJIJIIJJJJIJJHIEGIGHHF9BCDDDDDDDDDDDD<CDD@CDDDDDDDDDDDA?<ABDDBDDDD>BBADCDAA3
@97O
CACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACC
+
BCBFFFFFHHHHHJJJJJJJEIIJJDI@FBFHGGIIJJJJJJJJHHFFFDDEDDDBBDDDBDBCCCCCADDBDDDCDD8AB?ABCC<ABCB@BDDC@CCD?
@97P
ACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCG
+
CCCFFFFFHHHHHJJJJJJIJGGJJG<F?DBDGHGIJIJIEHEBHGFFFDEEDDDDDDDDDDDCDCDDDDDCDDCCBBDDBDDDDDDDDDBB?BDCDDDD<
@97Q
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
C@@FFFFFFBFHDGGGHGHHIIIIJHI;FGCDHDGGGHHEHGHIGHDBBB@ACDBDDDDBBDDD>CCDCB>>C9??BA?2<AAABDDDD9?<<@>C>:?9<
@97R
CCGGTATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGT
+
BCCFDFFFHHHHHJJJJJIJJJGIIHIIIEHJJJJGHIJJJJIIJJJJJJJIHHHFFFDDDDBBDBDDDDDDDBDDDDDDDDDBABDDDDDDDDDC@CDD8
@97S
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
BCCFFFFFHHHHGJJJJJJJIJJJJEIGHGGJIJJJIJJJJIJJHHFFFFE@CDDDDDDDDDDDDDDDDDDDDACBBDDBDDDCADDC@BDDDCDCDCC@8
@97T
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
CCCFFFFFHFHHHJJJJJIJJJJJJJJGHIIJJJJJJJJHIJJIHHFFFFCDDDBDDDDBBDDDCDDDDDCCD?C?BDBBDBDDDBDDDBDDDDDDDDDD8
@97U
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
@@@DDDFDHFHHGIGA?EC>CGGIAGIEHD@GEHGIDGGGHAHIHEEDDDCCC??BBBBCCCC:@>CBCBC>A9?8A2?<AA?CBB?CB9<<AA@>CCC98
@97V
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
@CCAFFFFFHHFDIIIJJJIJGIDI@F?FG>AF<DCHA<F8GBGE>B???CABB==@=@@A@?CCCDBCBDCC?CDDBD@@BC<AADC@BBBDDDCD@CBB
@97W
CACGACCTGTAGATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
@@CFDFFFHFFDBGGHHHGHIGIHJHIIIIJJIGIJJIEGHIIIFFFFFFEDDDDDDB@BDDDDDDCDDDDDDCDBDDDBBDCDDBD<@<BABDDDDDCD<
@97X
GTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGAT
+
@@CFFFFFHHFGDFAFGGIIEG7@CFHIEGGHBEHFFA<?@>?ABABB@B<ACBCBBBCCBBBBBBCC@??(5;00<>:ACCCC@<@BBBCCCCC@CCCC?
@97Y
GCGGGTGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTC
+
@CCFFDDFHHGDHIIIBGHHIGIIJGGIIJIFHEDHIJGBGHEGGFGBGGHIGGIHIIGHCFHEB<;A;>;@B?C@CC@CCACBD:?CCDBCDDCC<A:@4
@97Z
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
@@@DDDDDAA?CFB?FBGIEHEHIDGEGEGEGEGIEG@D:F>EHEHEEDECCBCBBBBB=?C?CCCCBCBCCC9??BA@<?BC?B<AC>&8<8AACACA##
@980
GCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTG
+
CCCFFFFFHHHHHJJJJJJJFHIJJJJJJJJJHFFDDDDDCDDDDDDDDDDDDDDDDDDDDDDDDDDDDBBDBBBCDDDDDDDDDDDDDDDDDDDDDDDDD
@981
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
CCCFFFFFHHHHHJJJJJJJJIJJJIHHJJJJJJJJJIJIIIJJHHFFFFEDDDDDDDDDDDDDDDDBCDDDDDDDBDDDDDDDDDDDBDDDDDDDDDDB8
@982
GTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCT
+
@B@FFDFDHHGHHJJJJGIGIHIGFGJGBHGEFEGIJJGHGIIIHIJHG9CEHHFF>BEFCBDB?BCCD88=>?ABDCBDDCDECD@::?BDDDBDDCADD
@983
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCGGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
CCCFF:DDHHFHGIIGIIIID9CGGGBFHIIIE;?BFHIDGIIGHFDEBD3;?C?BBDDDDDDDCCD()5;@999?BDB888CCBA?AB>A?<@:(4>>>?
@984
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGT
+
CCCFFFFFGHHHHCIGFHHIJGI<FFGBFFIJIIIJFGIIIJGIHHFFFFEDD@B=??@=BDDCCDDDDDDDD(3?<AB?BDCDDDDDDDB?BDD######
@985
TTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCGACGGCTTGCTCAGGGCTGCCAGACACTTTTTCCTGAGACACCCTTTTGGTTTCAGAACTTTCTTCG
+
CCCFFDFFHHHFFHGBGIIGHG>EGHEHGIIIEH)1:@GIIIEEGIE>;FGIGEHEC?AED?CBA####################################
@986
CTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACT
+
CCCFFFFFHDFHFIGIIEHJIIJJJJJJIIJIGGIIICGHGEHIEGFF@DBFEFBHGGEAAE;?@BCACCDDE3>@AC?ACACBDCCDDDDACDCDD?ABC
@987
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTACGGAATAGG
+
BB@DFDDDHFDF>DHGGGEHGGGGIECFBFGIGDIFGFDAA@FHI@G@DHHH=?CCEDF@:??CCADC((,;?BB##########################
@988
GGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTTCTCAGGGGTGCCAGACACTTTTTC
+
BCCDFFFFHGHHHCGIJJJJJJIJJI'9',,::5>A:5(3(88>8A>?>>9A9A?@>C:A+:@B4:4>CC?##############################
@989
CACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGN
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJIJHIJHHFFFFEDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDD@BDDDDDCDDD#
@98A
ACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTG
+
CCCFFFFFHHHHHJJJJJJJJJJJIIFHHGIJIJIJJJGIHJJJHHHFFFEDDDDDDDDDDDDDDDDCDCDD9?BBDD?BBCDBDDDD>DAACDCDDDDBA
@98B
GCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCCGACCCTGCAGGGGTGCTCCTCC
+
C@CDFFFAFFFDBFGHIJIHIGJGEDGGIEFCHIIBHGHH@=DFFFFDCDDBBDDBBD?5?BDBDDDDDDDDBB8>B@<B<>>BD?ACCBBD@BBC@CCCC
@98C
ACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTG
+
CC@FFFFFFHHGHGEHIGHHGFGEGI??GCGHGIJEHID<AEHIAEHFEFEC?ADDDDDDCDDDDCDDDDDD9<@AA?@?ACDDBB?B0<ABDCACCC98?
@98D
ACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTG
+
CCCFFFFFHHHGGIJJJIJIGGGIIIFGIGIGIJIJJJBBHGHIHHHFFFFDDCCDDDDDDDCDDDBDDDDDCDDB?BBBACCBADDDDDBDDDACCD>B<
@98E
ACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTG
+
CCCFFFFFHFHGHIIJJIIJEIJIIICGGIJIIIIJJJJHFHIJHHHFFFDADDDDDDDDDC:ACC@C<ACDAABDBD?ABDDD@BCBDBDDCDCDD?BB<
@98F
ACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTG
+
@@@DDDD8FHBBHIGHIGI><FBGGE1:?GHA@GFEEHBFFF';=EH?D@B=1;=(5;8?@CC@:C((59@<C?<A8++8<9A8?AC-02(8:>@>439@?
@98G
CTGCCTCACTGCTGCTTTCCTCAAGGGAGGCTTGAGGCCGGACCTCTCTCCCAGTCTCCTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACAT
+
C@CFFFFDHDDFFHBGIGIHIDHEHIJBGIIGEH8DG<;DHHHAGHGIGIHI@GCCECEBDEF3?BCBD'58?343@CCCCDDCCB8@3558>:AAACC##
@98H
CGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGA
+
CCCFFFFFHHHGHJJJJJJGIJJIJHJJJJJHIIJJJJJJJJJJHHHHFFFFDDDDDDDDDDDDCDDDDDDDCBB?BBDBDDDDDDDBDDDDDDDDDDDD?
@98I
CGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGA
+
C@@FFFFFHHHHHJJJJJJJJJJJJEHIIIJJJJIJJFHIIJIIHHHHFDEFDDDDDBDCDDCDDDDDDCD?CDDBDDDDDDDDDDDBD?BDCCCDDD?B<
@98J
CCCCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGAC
+
CCCFFFEFHHHHHJJJJJIJJJJJHIJJJJGJJIIJJJJIJJIJHHHHFFFFDDDDDDDDDDDDDDDDDDCDDDDDDBDDDDDDDDBBBDDDDDDDDBBB@
@98K
CTTGGTGGGGGTGCCCTTTTGCTGGTGGCGCCATCAGATACATCAAATTCTAGTTTTACAGGTCCGCTCCTCGAGGAGCTGGCCATTTGGCTGCAGCCACT
+
CCCFFEFFHHH@FHJJJJJJIJJJJFCHBGIJIJJIJIIJJJHHHHHHFFFFFCEEDEDD@ACD>>BBD?CDD5<30<?<3<@BDDDDCCDC<<C?@B?CD
@98L
CCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGT
+
@CCFFFFFHHGHHJJIIIIGIJ=EGHHIJIIJJJ@GHHHGIJJJHDHHEFFDDDBBAC@@ACBDDDDDCDDDDDDABDDDDBDBBDBDDDC@CABBB?BD8
@98M
CCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJIBGEGIBHADEEHEFFFDEEEEEDEEDDDDBDDDDDDBDDDBBDB?CCDDDDDDDDDDCCCB?BDDDDCC
@98N
GTACATGATCATGCGGGAGTGCTGGCATGCCGCGCACTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCA
+
CCCFFFFFHHHHHIIIJJJGHIJJJJJJIGIDHGI';AHIJJHHHHFFFDDDEDDDDDDDDDDDCACBBDB@DDDDDDDDDBD<BDDDDDCD?DDDDDDD?
@98O
GTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCA
+
CC@FFFFFHHHGGIIJIIJAEHGIJGGGIIJBHIJGGJJIIIIHEEDEFFDDEEDDDCDDDDDDCCCBDDD?BDDDDDDDBDDDDCD@AACDDBDD@BB?7
@98P
GCGCCTGTGCCTAGAACCTCAGCGGGGTCTCTGAAGCTCTCCTCTTTCAGCTCCAAGGCAGGCTGCCCCTGCTGATGGGTGGGCACTGGCTCACTGCCTGG
+
CCCFFFFFHHHHHJJJJJJJJIIJIIJDGHIIGGIJJJJIJJIIIIIHFHHHHFDFEFDAABBBB?<ABADDACC@CDD>BDDBDBDDDBCDDDCDCC3:2
@98Q
GCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTC
+
CC@DFFFDDHHGHJEHIIJEGHJJJIDGIEHGGHIIIBHECHHGHFF>BCDCD;5;=:=2729A#####################################
@98R
CATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCG
+
@CCFDFFFHHHHHJJJEHIIJJIGIIIGGIEIJIGJIJIEHHAEHDEFDEEEDDDCD=ACDD<ABBB@<ABCDDBBDD<BBDCACDDDB?BBD@29??CD9
@98S
GCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGGCTCTGTCCTGCCAGGG
+
@@@FFFFDHFFFGIJIJJJAFEFCFH:@)779DFG6@AGG4;=DG@ECCECC6>?;<A?;=>:;'5(+(4>>5-523@9@>CC?&&5<CCA>C:4:8A>A<
@98T
TGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGAC
+
CCCFFFFFHHGHHIHHIIIJJJJJJJGIIHIIJJJJJDIHJHHHFFFEEEEEEDDDDDDC?CDDDB?BDDDDDDD>BD??CDDDDDD?BBDB?BD?ABDD@
@98U
CCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTC
+
CCCFFFFFHHHHHJIJJJIJJJJJJJIJJJJJIIIJJJIGIHHHHFFFDECEEEDEEDDDDDDDDDDDBDDDDDDDACCDBDDD@DCCDDCCBDDDDDDDC
@98V
CCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJIJJJJIGG<@G';-7;=E499BC>@;>A;@D;>>>8@?<=B##################################
@98W
TGATCATGCGGGAGTGCTGACATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGAC
+
CCCFFFFFGHHHHJGHJJJ*1CGIIJJIJJJJJJJJJJJJJHHHHFFFFEEEEEDDDDDDCCDBDDDDDDDDDDDB@BDDDDDDDDDDDDDDDDDDDDDDD
@98X
GTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCAGGTCCTC
+
CCCFFFFFHHHHGJJJJJFIIGGFIHIJIJJIGIIIJIIIGGDCGBGB39;>CDDCCC@C:C>>>8=@?3?355508<><<8@4429?<08<934<>>4>>
@98Y
CATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGA
+
CCCFFFFFHHFFHIIJJJJJJJIIJIIJIJJJJJIJIIIGHHFFFFCEEEEEDDDDDDDDDDDDDDDB<BCDBDBDCCCDDDDBDDDDDDDBDABDDDDBB
@98Z
ATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAG
+
BCCFFFFFHDFHHJIJJIJJJJGIJJJIJJJGIIIJJIJFGEBDFFFFEEEEEDD=CB5?BDDDDDDDDDDBDDDCDC@CC@@?@DDDD<8A8<3>B9?B?
@990
GGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCT
+
CCCFFDFF4DHFHIJJJIJJJJIIJJJJJGJJFIJIIJJIJIJJJJGGHHHHHFFFDDDDDCBDDCB;A?BDDDDDDDDDDDDDDDDDDDDDDDB@?CDD@
@991
CTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGGAAATAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCC
+
@@@DFFFFHFHGHJFHGIJJEHGI>GHIIE>EHGHIB-=4;77@3@@>@AECD@CCD;;;@C@:@5:5@@C(4@?>>CCC(38@99>-8>:>9AB?89?A#
@992
ATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAGGGGTGCTCCTCCGCAGGCTTCCTTAGGGATTGCAC
+
CCCFFFFDHHGHFIHIJ@FGIIJJJJIHJJDDFDDDCDBDDBDDBDDDDDD?BBDBDDDDDCCDDCDBD>@@CCDCCDBDBDDDBDDDCC<@CBCCDCCCD
@993
GTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCT
+
@CCFFFFFHGHHHIJGIIJEGHIGIJIJIIJGJJJJJJJJIJIJHII@AHFGDFFDEEECDD?8?5?CCCCCCB@ABBBBDDDDDDDDD@<<?34@:@CB<
@994
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTG
+
CCCFFFFFHHGHHJJJJJJJJJJJIJJJJJJJJIJJJJJJJJJJGIJIHHHFFFFEEEEDDDDDDDDDDDDDDBD?BDDDDBB>BDDBBDCADECDDDCDC
@995
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTG
+
BB@FDDFFHHFHFIGJIGIJIIDGB6BFGGIJIIG@FGGHD=@F=CHAHH=BDCFEDE@BD?BBDDCCD>@8A8888>@<CBB@D@>B<?CA(:A######
@996
CTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTG
+
CCCFFFFFHHHHHJJJIJJJJJIJJIJJJIJIJJJJJJJJIIJJJIJJJJIJJJJJJJJIJJJJIIJFHHHFFFFFEEEEEEDDDDDDDDDDDDDDBDDDD
@997
CTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGG
+
CCCFFFFFGHHHFIJIJIIIHIJJIJJJGHGHIIJJHJJJJJGCHIIJFHIJJJJ=CEHHHHEHHFFFFFD?ECD@CDBDDDED@CDDDDDDDCDBD??CC
@998
AGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCCCACACCTCAGCACTCTGGGGGGCAGGAT
+
@BCFFFFFHHHGHJJIJJJJGGIGJIJJJIJJ@HIJIJJJGHDGGGIIJIJGIJJJJIJJIIHGHHHFDCCDDDDBBDDDDDDDDDDDDDDDB@DDDBDD<
@999
CTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTG
+
@BCFFFFFHHHFHJJJIGGIJIJJIJJJJJJJJJIIJJJGGJJFEIIGHHEEFFFDEEED9ABDDDDDDDDDDDDBDDBDDDDDDBBBDBCDCECCBCDCC
@99A
CTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAG
+
CCCFFFFFHHHGHIIJJJJJJJJJJIIIHHHIJJGIHGJGGAGEHIAHHJGIHIDHHIJHHHHHFFCBCFDEDEEDDBDDDDDDDDDDDDDCDDDDD@CDC
@99B
GATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTT
+
CCCFFFFFHHHHHJJJIIJIIIHIIJIIJIJIJJIJIJHHHHHEEDFDBDDDBBDDDDDDDCCCDDCCD>BDBDBDDDD7>BD?CCCDDDDBDCDEEDDE@
@99C
GATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTT
+
@CCFFFFFHGHHHJJIJDGIGHEIIIJJGGIGIJIJ8AGFHEH>DBECDDDDABDDDDDBDDDEDDDDDDDDDDDDDDDBB9<<?CACDDDDBCCCADDDD
@99D
GTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGT
+
CCCFFFFFDHFFFIJJIJJIJJJJJJBHIIIGGGIJJJJJIJ??FHIJH@HHIHIGGIGJHHHDD@&0)5<AA@###########################
@99E
CTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGGTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTT
+
???DDDDDDDDD)6??/99=BD<B8==A9A=C@AAA;?;A27=?;3.;>@6;((5=;,;23=08:44+9<<1;8<>4<<134:AA(:::98<>>????>>>
@99F
CCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTGCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTGGCCTGGTGCCCCC
+
@CCFFFFFHDHHHJJJJJGIJIJIJJIIJJJ?FDDGD;DEHIJIGIJ;FF(>EHHIHHHGFF1;ACDCDDDDD@BAD4>:>>A83:(>ACBCBB#######
@99G
CCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTGGCCTGGTGCCACC
+
CCCFFFFFHDHFHIJIJJJIJJIJJGIJIIIFHIG=FEGIJIIIJJJAGHGHGIEHEEACBFFDDD=A=;?BBBDDDCDDAAC@DDCCCDDD?ACCCDCC8
@99H
CACGGCTTGCTCAGGGCTGCCAGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAAATTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGGCAGCCA
+
>>>AAAAA0+>=<=CC+=<<A<<=1=:7ABB*?07?5=9;A>A==AB<>7==A=7>AB)7=7>=3=A;;=;7>@(;<;;;;?=9=;?##############
@99I
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTGGCCTGGTGCCACCCGCCTA
+
CCCFFFFFHHHHHJJIJJJJJJJJJCFIIJJJJJJJJJJJJDFFHJJJJIGHHICGHEHFFFEDCDD/??@>CCDDDDDCDDCDDCDBCC@CCCDDB@D>>
@99J
CTTCCTTAGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGGGGAGGCTCCGCT
+
<;;BD<BDFFFD;?F>@F;CEFCCF+?06D)BB@;??<C38BDEFI:>6?@@C@2(5(58=@9?/(58>50(+((4939@B?05<B###############
@99K
GTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTG
+
C@CFFFFFHHHHHJJJIJJJJIJIJJIFJJIIFICGGH@GHIIIFHDHEHIIJJIJHIHGCCE@>BECBBCCDDDDDBDDDDD@CB<BB@?B?B39@@BAC
@99L
GTCCGCTCCTCGAGGAGCTGGCCATTTGGCCTGCAGCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTN
+
@?@DDD?DFBHHDACDHFEH<BHB;FA<4DBE6BGGIGGI>?DGHGI<F>A;@DAAACCH=AB7@?DCC=@=AC5?@AC95<(,585?BB@?BB@05<B##
@99M
AGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTC
+
@@CDDDDFHFFDFEGIGGJCDEDHGJG:@FHGIIDEIJICHFFEFDABDDDDDDEDDDDDBDBDDDDBBBDD>98>ACDBDDDDDDEED>::@4:>5>BB9
@99N
AGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTC
+
@CCFFFFFGHHFHJJJJJJIJJJJJJFEHIJGIIJJJJJEHFFFFDDDDDDDDDEDDDDDDDDDDDDBDDDDDD@?CDDDDBDDDDEEEDEEDDDDDDDDD
@99O
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTGGCCTGGTGCCACCCGCCTATGCCCC
+
@CCFFFDFFHHHHIIJIIIHIHDHI=FHGEGAFFH@EGIIGI@GGGGIJIGFHIJJHG<DCB@AB;@C@CCDDDDDAABCB?:A@C:ABBBBD-5@:@@<?
@99P
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTGGCCTGGTGCCACCCGCCTATGCCCC
+
@@@?D:DDHHDDHGCH?GB?E?;E@?E;CE9FH9D)808?DFH?;ABC;;@;5;;DE8=5=9=;?5:@35>B<CCC:(8AB<+93+(4<59B>B9CCCC98
@99Q
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTGGCCTGGTGCCACCCGCCTATGCCCC
+
CCCFFFFFHHHHHJJJJJJHIIIJIGIIGIJJJJIGHDGHIJJJGB@CCFHHJIIJHHHDBBBD@>>CDA:??CC(5:<>88(3>?3@A>5>B99AAACDB
@99R
AGACACTTTTCCTGGAGACACCATTTGGTTCTCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCC
+
BBBFFFFFHHHHHJJIJIJJJJIIJJJJHIIJJJJJJIJJIJJJJJJJJJJJJGHIGGIJJJEIHIJJJHHHHHHFFFFEEDDDDDDDDBDDDDDBDDDDD
@99S
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTGGCCTGGTGCCACCCGCCTATGCCCC
+
BB+ADDFFHHHHHJJJJJJHIJFIIIJJJJIJJJIJJIJJJJJJJJHJJJJJJIJJHHHFDBBBDCDDEDCDDDDDDDDCDDCCDDDDDBDDDB@ADDDDB
@99T
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACGTGAGTGCTGGCTCTGGCCTGGTGCCACCCGCCTATGCCCC
+
CCCFFFFFHHHHHJJJJJJFHGIJJHJJJJJJJJJEHFHIIJJIJJIJHIJIIGHJGGHFDDD@DACCEADDDDDCCDDCDD@CACDDDDDBDDDDCDDDD
@99U
CCCACTTCTTCCTGAGGACTCAGGGTCATGGCCCTGCCAGCCACCAGGTGGTTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGT
+
C@CFFFFFHHHHHJJJJHHJIFIIJCGGIIIIJGIJJJIJJIJIJJIJFGGFGIIGJIIGGFFD@CEDDDCDDDA?@DDCBB>?:<ABDECDDB@CCCCB8
@99V
TCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCAGCCAGGGCACCTGGGCCAGAAGGCCCGCCCCACACCTCAGCACTCTGGGGGGCAGG
+
CCCFFFFFHHHHHJJJJJJJJJJJIGFHIIEGEEGFFHGGIEBFHEHIHJJGGIJIIJJIHIGHHFHDFF=BDDDD?@<BBCDDACCDADDDDDDDBB5>5
@99W
GCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGCGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAG
+
=??DDDD?:<DCF:@DFFB?CEG@@CGFFF@;GE:?B98BD2B@8CFFC@-.=ACAEEDDD'3>=8'08<4?;@@599?9A??<+:(>@>259&5@B@###
@99X
CGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGA
+
CCCFFFDEFGHFHJIIJJIIGIJJIJJJJHIJJJJJJJJJIJJJJJHHHHHFEFFDDDCDBDDDDDDDBBBDDCDCCDD?B@BBBDDDDDBBDDDDBCCA>
@99Y
CCCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCCCTCTTCTGTGTCTGGGGGCGG
+
CCCFFFFFHHHHHGI<GFHIIJJJIJJJHGGHGIJFHIJJJJJJJGIGIIJH>CHFFFEDEDACEDDDCD?BBDB##########################
@99Z
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGG
+
CCCFFFFFHHFHDIJIIHIJJJJJJJIIHGIGHIIGGIJJJJJJJIIHIJJIEHHFHFFFFECCECEEDDDBBB###########################
@9A0
CCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCA
+
CCCFFFFFHHHHHJJFHIJJJIJJJJJJJJJJ;GGIIJIIIGGGIJJJIJJIJIC9>3(;>>A:AC@>@C###############################
@9A1
CCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGTC
+
CC@FFFFFHHFHFJIJGIJIIGIJJJIIIIIJJJ@DHHIJJJJIJIFCGIJAHHHHHFFFFFEEEDECCBD@BB###########################
@9A2
TCTCTGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCAAC
+
:+=BD??BFFD?F<FGFI<??EE<;88CEFFCFGIE@*98BFEFIIIICDE>ACEC;CEDB);@>;6@B???9;AA@>@:9>:?#################
@9A3
TCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACA
+
CCCFFFFFHGFHDIIIGIIIJJGJGFFIIGCHHIHIGGIHH?DEFFFEEDEEDDCDD?A@BDDBDDD?DDD?50?<?ACDDDDB?A<?B?@??CD@#####
@9A4
TGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCA
+
@@@FDFFFDHFHGGDHIIJGIEGGIFGHGHIJJJJJICHGIF@GGIIIGJ;CAAHEHEHF@DCFFDEEBDDDD-5))234>CC##################
@9A5
CATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCT
+
CCCFFFFFHHHHHJHIJJJJJJJJJJIJJJIJJJJIJJJGJIIJIIJJJJIJJJJJHHFFDDDDDDDDDDDDDDDBDDDDDDEEDDDDEDDCDBDDD@BD@
@9A6
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGCCTCCGCTTTGTGCTGGGACTCTGTCCTGCAACGGTCTTCTAGGGTCTCAGAGGCGGGTGTCCCTCCT
+
CCCFFFFFFHHHHJJJIFGIIIEGIACEAGEBHIJJIIEEHIIJGGIGIJHHFCEDD@DDCEDEECBD,<=@CCDCDD>?CCDDDDDDBD###########
@9A7
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCA
+
CCCFFFFFHHGHHGIGHIJJJJJJJJFHGHIJJEIIIIGGIJJIIIIHIJGIHHHHFGHFCFFEEEEEDDDDD&9)0<@>@CC:>>C>+4590?@######
@9A8
CATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCC
+
@@@FFDDAD@CDAA?FDHICHIEGDFEGIGIGGGGIICGE7=F;DHACECCEBFFD3=A=@>ACCCD?A7?<8;@?A<@9@>BCBCCC?<++:>CA?BDDB
@9A9
CAGAGGCGGGGGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGCCAGACACTTTTTCTGGAGACACCATTTTG
+
???DDDDDDD0=<<;;;A6>;555;>5>:<35:A>A3>283>8<3>A?(39>A<<0605<-2::49A?#################################
@9AA
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTG
+
@@@FFFFFHHHHHIEGE@FFHIGGIGGIIIIIIHIIFHI=FHGHIIIIIIHFEHBFDFFCEEB;;;=?8??@CBB9><>CBC>CCB:@CCCCBBBBB>B@@
@9AB
CCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGGCACGGTCCA
+
C@CFFFFFHHHHFHGIIHIJJIIIIIIJIIJJ:DGGIJEHGGIIIIIJIIIGB8='5&)(33:@C3:3:@A##############################
@9AC
GCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTCCCCGTA
+
CCCFFFFDFHFHGIIFHIIGIEEAG?CDGGGBFGIIGIICHBGGGIGHIJJJJJJJJJIHGBE=CDEEECEDCBB>CCDDDCCDDBDDDDDB9>A?@D>55
@9AD
CGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJIJJJJJJJJIIJ@GIJJJIJIJHGHFDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDCCBBDD@DDDDDDDC
@9AE
TCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTTTGGCGGTGGGCG
+
@CCFFFBDFHFA;FFGHG@FGGHIGHIIIGCCGCGI@FHIGIIGGEHIEHIIH?EFFEFFFFDACC@DDCCBDDBD#########################
@9AF
GTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCC
+
CCCFFFFFHHHHHIJIIIJJJJIGGIIJGFIIIJGIHIIJIIIJIIJHHHHHFBEDEEEED?B=BABCDDDACD@A@DDDDDD:<9<BBDDDD:>CCCC@9
@9AG
AGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCC
+
CCCFFFFFHHHHHJIJJJJJJJJJFHIGIJGGHIIJIJIJIIHIIJIIJJJHIIJJHHHFFFDDDDDDDD>ACDDDBDDDDDDDDDDDDDDCDDCDCCDDB
@9AH
CAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAA
+
CCCFFFFFHHHHHJJJJJJJEGIIJFHIFHJGJJIHIJJCGGGFHIGGJJCHHIIGHHGEFFFDDD>BDDCDDDDDCCCCDBBDDDDDDDDDDDBDDDCCD
@9AI
GGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCA
+
CCCFFFFFHHHHHJJJJJIJJJIJJIJJIJJJJJJJJJJJJJJHHHDFFFFFFEEEEEEDDDDDBDCEDDDDDDDDDDBDDDDDDDCDBDDDDDDDDDDDD
@9AJ
TGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCC
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJJJJJJJIJJJIIIAHIIJHHHFFFFEECBBDBDDDDDCDDDDDDDDBDDDDDCDDDDDDDDDB>CDDDDD@
@9AK
GGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGCCTTCTAGGGTCTCAGAGGCGGCGGTGACTCCTCTGGGTCTGGGGACGTCAC
+
1;=;??AD7@DD1EE9A:E?6?)??:B**09BB8B3//B).8=B=@ACC(-;CC=ADC?@?@D>@3>?>8?##############################
@9AL
TGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGCGCGGGG
+
B@BFFFFFFHHGHJHIIJIIIIEIEHHIJJEIJIHHIIJJIHGE>DFDFEE@CDDDBB<1;@B;>8ACCCB@55?4>A:A>@@:>>A9><?>?########
@9AM
CCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAG
+
<@@DBBDDF?FFHHGIIGEG9D?3FAD9?C?BDBBFEGIBF)@<@CFH@GFHE8;CAEEEB??CB<@?==CBCCC?<4>CC>C8@@BBBBCCCCCCB?C?C
@9AN
CCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCAG
+
CCCFFFDFFHHGHIIIGI?FG@DH=CF;FHEHIIFHBFHBCFGGHBCGGGCFHGHGHBBF:>AB>CCCCC@B@BB<>CCCCCCBBCCCCCCCCCBC?ACC@
@9AO
TCACCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACT
+
BC<DFFFFHHHHHJJJJJIJIJJJIEGIG;CFEHEGFBAGHIIGHIGIIHHFEHBFFFFEECEACC=CCDD9>CDCCDCCDCCDDCCCDDDDDB#######
@9AP
CGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGA
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJGIIIJJJJJJJJJJJJHHHHHFFFFFDDDDDDDDDDDDDDDDDDDCDDDDACDDDDDDDDDDDDDC
@9AQ
TGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJIIJJJIJHIJIJHHHFFFFEEEDBDDDDDDDDDDBDDDDDBDDDDDDDDDDDDDDDDACCDDDDD
@9AR
GCGGAGTCTCCGCTTTGTGCTGGGACTCTGCCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCACGGGAAGGA
+
CCCFFFFFGHHHGJJIIGIIJJJIJJJJJJ3DGHGIIJJJIGGIJIJIJJCGHHIJJJJJJFDD&5):::@@@A###########################
@9AS
CCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTTAGGAATA
+
BCCFFFFFHHHHFGIIIIGGIGIIGGGIIIHIIIIIJHHEHGGIIGGGHHFHHH@BEDFDCCDDCDDDECCDDDDBD########################
@9AT
CCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGTCACGGTAAGGACACGGTCCA
+
CC@FFFFFHHHHHJIIIJJIJJJJJJJJJJIIFHIJIIJJIIDHGIJJJJIIIID/5&)2:>A:@:>:@@>>9@&29(+5)5<@<>22<@A38920<2?@3
@9AU
CGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGA
+
@CCFBDBDBFHHFEEGHEHBGBHIGGHIIFIII?FHGGGIIIIIIIHGFEHF;@?2=BC;?CCB?B?B;A8<>>3(:>52(((+(&2<:<93<<>CBCCCC
@9AV
CCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTG
+
@@@FFFFFHHHHHJJJJJJJJIJJIJJJJJJJJJJJGIJIJJHIJJJJJJJHHHFFFFFEEEDDDDDDDDDDDDDDDDDDDDDDDD>CCDDDDDDDDDDDC
@9AW
CTCGGCTCCGTGCGGAGTCTCCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGGCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCT
+
???DBDDDDDDD11@1EE91CBD<D@:D4*B?9??B8<8@AD=A5'.(':=59',=;<28?2<AA?>4+:(((++4+4>AAA><AA??<33((4>AA####
@9AX
CGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGA
+
@C@FFFDDHHGFGIGEGIGIIIJJGIJJIIJJJJIJJJIJIJIIJIHGHEHFBDFBDDCDDDDDDDDD;?BDCCCACDD@A?BBBBBDDD>DDDDDBDDCC
@9AY
CCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGA
+
CCCFFFFFHHGHHJJJJIIJJJIJIICFHCHIGIJIIJJJIJGHBFHJIJJHJHHGHHHFFFFEDCBBDDDDD??A4>CCCDBBBDB>DCDDCDDDDDC?C
@9AZ
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGT
+
:?1=BDDDHFDBFHIIICEHIEGHEHGIFGFBGHGBFBGGEFEHFAH;DGIGHHFHEEFFFFDCDEEDACBB?B###########################
@9B0
CTCCGCTTTGCATTCTTCCGCGGCTCCGTGCGGAGGCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTTACTC
+
CCCFFFFFHHHHHJJIJIJ33@FEIJIGHGEIJEI'?AEH>DEDDCCCCDDDB?ADDDDCDDDDDCCC@B8>CCDCACDBDCDDCC::??###########
@9B1
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGGCGTCA
+
CCCFFFFFDHHHHIIEHHGGGEBHJGHGCIIJIGHJIJIEGGEGIIIJJJCGFHHHHGGF;;BEEECEDDBDD############################
@9B2
TGGGGATTGCACCAGGAGGCGAAGTGGCCACTGCTGCGGGAGCACAGACCCCACCGTGCCGGCATTCCTCCTCGGCTCCGTGCGGAGTCTCCGCCTTGCCT
+
CCCFFFFFHHHHHJJJIJJJIIJIGIJJJJJJJJJJJJJJGFGFFFFEEDDDDDDDADDDDDDDDDDDCDDDD@DBDDDBD?5<905(9CCC#########
@9B3
ATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGA
+
CC@FFADDHFFFHIIJGIGIGDGIIJIFHIJJIEI;EHGDEEDFFFFFDEEDEDDCDDBBDBDDDDDDBCDDD?A@A@CC?BBDDDBDBBBCDDBB@DCA?
@9B4
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCTTGCA
+
CCCFFFFFHHHHHJJJJJJGHDBHHJJIJJIIIIJDGGGGGIIJJJEGFCHDHIIJHGFFDDE?B5@;@CCDD=BB9>CCDDCDDDDDDCDACDCDDCCDA
@9B5
CGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGT
+
CCCFFFFFHGHHHFIJJFGHIJJJJJJJEGGFGHJBHIBHIJJIIJGHIIIIIHIGEEHF9B>CDDDDCDDDCDDBD@BBDDCDDEECCDDEDDAB@B###
@9B6
AAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCCTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGCTCCT
+
@@@DFFFFHHHHDHGGIIJIICHGIG>GHGBFGGHGEFEHEH2;BFDD(6(-;AD;CCBD:?C:@A:?CDDDDDBABC:@>28<9<3:>:@@AC#######
@9B7
TCCACGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTTAGAGGCGGGCGTCCCTCTTCTGTGTGGGTGGAC
+
?<?=DDDDH@FA+CFFHIBFD4BFGG6D=F8B8==FF@9=7@DGCECDE;7=;;;@;>C##########################################
@9B8
CCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTGTCGGGGGACGTCAC
+
B@CFFFDFHFHDDHIJIG?BHGJGHGGIIBFEHJJJGIEFECFHGIIHGGHID2?CEFFDFFC@ACEDDCDBBBDD00)(4@>ACC:A#############
@9B9
GTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCTACCCGTACCCAGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGCG
+
@;@ABD=AFFFDFFI1??C>FGIIFIGEFEADFFG90?BDF<:(66&0:8??BB<B@8A:?@BB@>98>:@B@(8?(28<A>3::A:@A>34:A>3?<?##
@9BA
CCGCTTTGCATTCTTCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGTTCTTCTAGGGTCTCAGAGGCGGGTGTTCCTCTT
+
@C@=DDDFHHHHHIIGHII@FH=GIIGIIBHIGIIIEDFHIIIIGHIIIGGDHHHGHEFFFFFC>AB(-;ACDDDD>ACACCDACDDDDDD-5)(+4>>AC
@9BB
GTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGG
+
@C?DDDFFFFFBAAEH+A@3?<CEA@+C>9??99?F@GGCGIEFAFHEGEH@C4FA(.)4;/=/''8(3@??@B&)0-05<??0+8<?18<882<>@####
@9BC
GAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCCCCACCTGCACACACGATCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGAC
+
C@@FF8D;FFBF8E3:E<@FG>><@@1C1:):?6)6?<<DB>B18'-5:'5?DEDCC;5;'',5AA@A5>@C((,544@-59>52(4>>>8?(8340905@
@9BD
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGGCGT
+
CCCFFFFFHHFHGJJJJHHIJJJIEIJIIJIIGHGGIJHIJJJIJIJ>HIJJACHGHF;B@DDEEE@CED?BDD>090:4::@@#################
@9BE
CCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGA
+
CCCFFFFFHHFHHJGIJJGCGIIJJJJBHIDE?1BGHGIIJJGGGGIIIHIIGIHJCHGFFFDEDDDBBDDCD@A>::@@B@DB9>>C>CDC<AC?CDCC#
@9BF
CTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGCGCTGGCATGCCGCGGCCTCCCAGAGCCCCAC
+
?@@AD>DDHAC@DFBGG::?FAEDGH):?FFF@7:FE9@=.==5AABHF4;;AC>>>C<A>CA######################################
@9BG
CCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGCCCTAGAC
+
CCCFFFDDDHHHHIGIGHGEBBGDBGIEI@BFHGHHIFG@B;CCCGIIGGHHEEEDBD=BDDBCC<BBB@B@B0<@CA>A><?<CAD?C############
@9BH
ACGGGATGAAGTTTGGGCCATCCATTTTGTCCCAGTCGAGGTGGTAAGAGCCCCGAGAAGCTGGCATGGCGCGGTCCTCTCCTGCTCCGCTCCTACCCTCG
+
@@<DDDAB8+CC><CFG3<AE<<FHCHG@GHGDD<<D@DHB?DHBBGE)83BFABB<AAC7;?3=@@65(3'3')55:A4?>:(:4+:>B<BB9AC@####
@9BI
ACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTG
+
@@@DFADEDF?AFHBHBEGI<GGI>G)?<?FH7B<F>BD6A<@@<=ABDEBC@;=??=6?ACA@CA?C<CDD<CBBDD028<CBB@9<5<?1:@:@A####
@9BJ
TCAGAACTTCCTGGGCTCTGGGAAGAGCTTGAGCAGTCCAGGTCACCCAGGGCACCTGGGCCAGAAGCCCCGACCCACACATCAGCACTCTGGGGGGCAGG
+
@@@DDD2=CFF+<+<EFIEHFBCFFDBGCF>CF@F?CBGAFE?DG*00??;<FFF?A;=C<A(?=7?)(64''398?B?B+4>@:>:?33@A@@@<<B###
@9BK
GTAAGGGTCTGAGTGCCATCTGTTGGCACGGGGGTGCCCACACCCGCAGGGCAGCCCAGGGCTTCGCCAGGCAGACCCTGCAAGCGTGCTCCTCCGCAGGC
+
@@@DDDD;D>FF?CBFHIEID@:AA;GGDFHBFH44;@E3?EEB9<A@B??882<?BB@BB08298;>85<<??(82A?9AC++(+8&&2>ACCABB<0<>
@9BL
CACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGGCGCGCCCTCCCAGAGGGCCACCTTCAAGCAGCTGGTGGAGGACCTGGAACGTGTACTTA
+
@@CFDA8:DC:DCGGHGIIFHDHGDGGG6@F6?FGIGCFFB(=;8@8'9>=A15;;A8'8?8?58(+:+4:?9ACCD3((++8?BD?<?############
@9BM
GACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGAC
+
CCCFFFFFHGHGHIIEIJJBHHIIGDHFGGEHGIFGII<@FGHIFHHGHDFDACBCBDCCCCCDDDDDDCCCBDD@BDDDCBDDDB9A?A@CDDDD@?B?<
@9BN
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGGCGT
+
CCCFFFFFGGHHGJJIFEGHIJJIJJIJGGIDGIJIJJIJGIIHHGIFDHGGEHHHHFDFFFFEEEBCEDDDBDD<<<<>@@CDD@C##############
@9BO
TGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGCCGTCCACCGACAAGAGTGACACCCGCCTCTGAG
+
@@@DDADFHGGGHJJJJIJIHIJIJIIIEHHJIEC;CCCFHGGICHEHCCEFCDACCB>@C>CCB@D'9'85;8:<BD<@B?CB>A>ACCDD@BB9<AC@C
@9BP
CCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACAAGAGTGACACCCGCCTCTGAGACCCTAGAAGA
+
CCCFFFFFGHFHHIIIHIIIJIIJJJJEGGHHIEIJJJJIJJIIHHIJDGHJJHIJHHGFFFCEDDDDDDDD?:@@CAC@BDDDDDDCC@CCBBCCDDDCA
@9BQ
GGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCCATCTTCTGTCTAAGGAATAGGAACTAAGGGTTTT
+
@@@F=DDDHHGDFI9A:CEHGGHIJE>D9?F>*9?D?=FBGGIGHI4?DBFDCGG@FCHHF########################################
@9BR
CTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAGCCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCC
+
CCCFFFFFHHHGHIJIFGGHIIJIIJJJIJIIGGHGIJJJJJHIJJJJJHHHHFF,,,,3;>;@CDDACCEDDCB@BB@(8ACDC<ACADCBDDDBBDBDD
@9BS
CAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGGTTTCCTCCACGGCTTGCTCCGGGCTGCCAGACACTTT
+
CCCFFFDFFHHHGIIGGHIJJJJJJJJJI',3,55,5(883>33>>>@C3?@>>C>A<>3:@3(+2?:>>>AA?8<<9@######################
@9BT
GTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACACTCACCAGAGTGACGTCTGGTCCTTTGGGGTCCTGCTCTGGGAGATCTTCACGCTGGGGGGCT
+
BB@FFDBDFHHH6FBBEEGGGIIIIGGJHEEHIGI>FGGGGIGGHCE=@FGIGIHFHEADCFDEF3>ABBDD3>CCCCCC?B5?@ACC@CDDDD@B.95>B
@9BU
CACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACC
+
CCCFFFFFHHGHHJGIJIJJJIJIJJJJJIJJJIJIJJJJJIJJHHFFFDDEEBDDDDDDDDDDDDCCDBDDDDDDCDDDDDDDDDDDDDD>ABDDDDCDC
@9BV
AGAGCCCCGAGAAGCTGGCATGGGGGGGTCCTCTCCTACTCCGCTCCTACAGTCGTCCTCCTCCACCTCCTGCGCGGCCTTTTGCTGCCTCGCTGCTGCTT
+
CCCFFFFFGHHHGGIIJJIJDHDGGG6:67AAC8CAC(+8@C2:BDDDDD(>@CBBDB2>ACCA3?ADABC3+5&&5>BDDA@CCCCA?(4098&5@CCCC
@9BW
AATAAGACAACCAACGGCCGGCTGCCCGTGAAGTGGATGGCGCCTGAGGCCTTGTTTGACCGAGTCTACAATCACCAGAGTGACGTCTGGTCCTTTGGGGT
+
1:144ADDDAADFFHBGHG<D@@0B>DF0@FGB=F3=@@;@;AEDEED?5=@3>(-;;5:@2872<4>+(+49@CC:<AB++4@<<<<89(4>>@C43590
@9BX
CGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTCTAAGGAATAGGAACTAAGGTTTTCCTCCACGGCTTGCTCAGGGCTGGCAGAAACTTTTC
+
BCCFDFFFHHHGHJEHIJJJJJIJJJG-;A77C==.?7=);;?>B>C>>A>>C@CBD@C>A,:AB:AACC(38;<@#########################
@9BY
GCTGGCATGCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACAC
+
CCCFFFFFHHHHGJJJJIJJJJJJJJJJJJJJJJJJJJIIJJJJJEHHHHHFFFFEEEEDDBDDDDCDDDDDDDDBBDDDDDDDDDDDDBDDDDD@CCCCC
@9BZ
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTCGGTGGACGT
+
CCCFFFFFHHHHHJJIJIIJJJJJJJJIHIJIJJJGIGGIJIIJGGIJJIJJAEHHHFFFFFCCEEDEEDDDDDD&5058A>@@C################
@9C0
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGACGTCA
+
CCCFFFFFHHHHHIJFHIJJJJJJJJFHIJJJJGJJIJJJJJJJJJIHIJCHHHHHHHHFFFFEEEEEDDDDD5>5:AACC>C>A@AAC:5<08>1:9992
@9C1
CCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACCCTAGAAGACCCT
+
CCCFFFFFHHHHHJJJJJJIIJIJJJJJJJJIJJJGIJJJJJJJJJJJIIIJJJJJHHHFDDDBDDDDDACDDDC?@BDDDDDDDDDDDDDCDDDDDDDDD
@9C2
CCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGAGACC
+
@;?D=;DD??C?CFHGGE@EHGDHDEBB;?D?CD;DG?AD;D;2B=@@=FGIIEC>E85(5;?5=A1>@68;/3<+9(+9?:@:>@C?BBB<<9>CCC>A8
@9C3
TCCTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGTGTCACTCTTCTGTGTCGGTGGAC
+
CCCFFFFFHHHHHJJJJJJHIJJJJJJJJJIJJIJJJJJJJIJIIJJJJJJHHHCCFFFFFEEDEEDDEDDDDBDDD)504>A>@>A>:3444:3<08>24
@9C4
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTCTGTGTTGGGGGGCGN
+
@CCFFFFFHHHHHJJJJJJJJIJJJJJJIJJJJJJJJJJJIHIJJJJJJJJJEHHHHFDFFFFEEEEEEDDBDDD##########################
@9C5
TGGCTGGTTGGGGCTGTGCTCTCAGGAGCAGAGGTGTGTGCACAGGTAAGGGTCTGAGTGCCATCTGCTGGCACGGGGGGGCCCACACCCGCAGGGCAGCN
+
:11=BBDDHD<FDGIIFFHGGIFCEFCGEHHBF7FF9?9BFDHGIDBBDGGEFGGHAH@>EHFHFFFFEFDCECBBBC@&&)5>0<8<@BB35>@BB@B?#
@9C6
GCCGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCN
+
@@@FDDDDHFHGHIIIGIIGIIIIIIIIIIIGIGGGIBFHGGEHCGHIECEHEDDCECEECCDB@BBDDB@DBCD@@9509?ACDCB@ACDCCD<>BDDB#
@9C7
CTCGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGGCACTCTTCTGTTTCGGGGGGGGN
+
BCCFFFFFHHHHGJJJJJJJJJJJJJJJGGJJJJJJJJJJJJJJJJJJJJJJEHHHHFFFFFFEEEEECDDDDD@##########################
@9C8
CGCGCCCTCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACGTCCACCGACACAGAAGAGTGACACCCGCCTCTGN
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJHJIJJJIJJJJJJJJJEHHHHFFFFFDCDDDDDDDDDDDDDDDDDDDDCD>CCACDDDBDDDDDD#
@9C9
CGGCTCCGTGCGGAGTCTCCGCTTTGTGCTGGGACTCTGTCCTGCAAGGGTCTTCTAGGGTCTCAGAGGCGGGGGTCACTCTTTTCGGGGGGCGTCACGGN
+
B@BFFFFFHHHHHJIJJJJJJJJJJJHIJJJIJJJJIJJJJJJJJJJJJJGHHHHHHHHFFFFEEEEEDDDD#############################
@9CA
CTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATAACATCAA
+
@@@D;BDDFHDF?AFGEI9AEHIIEHGA?<?CC*?9C9CGFE<CGA?FE<GDC@G67=@CFH)7=4=@C################################
@9CB
CGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCT
+
CCCFFFDFGHHHHJGHJIIIIJIJIIIAHGIGIIJDHJJJIJJJJIJIIIJFJJIGHHGGGHIIJIGGEHIDHGBDEEEBDFCDB6A?BC>ACCDECB@78
@9CC
GGGACTTGAAGTTATACCAGTAACCTCTACTACAAATAAAATTACGGCCGAAGACTGTACTATGGAAGTTACACCAGGTGCAGAGATCCAAGATGGCAGAT
+
@@<1BDDFHDFFDFHIGHGCFCHHEFHHICHIIE@<FFGHHIGHGIGIEHEHA;@GFD7>=7C@>E;==7@DFC@(65.5;>C;5;:C>>>@<@>(538?C
@9CD
TGTAAACTCAGAGAAAGAAACTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGAAACAGCA
+
??1ADDDDBA?DFCEHGA?EBDCDHIGEEGDHIE<EDGAAHGBCEH>FE*BGCGGIIIGCGGA@@FICDE>E>CEC;6?2?;B@CCBC'39?C??CCC<<3
@9CE
CTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTTATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATAACATCAATTGCCCC
+
+==AAAAABB?B>AB><+?@3?A7ABB>>A=A?B*:?AAABBB8AAAAA(7ABBBB>>AA>;;55'6>;>>3;?9;@BB@:3;3=6;15;;?::;;8:??;
@9CF
GGAAACTCAGAGAAAGAAACTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGAAACAGCAC
+
@B;DDDFFHGHHHJJIIIJJIEIIIJJIGG@GGIIJIJIJIGGJJIIJEHJHJJIJJJEIEHGGIGGHJJ>CAAGAEFEEDFFFDAC?BDDDD?>?C?BC?
@9CG
CTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGAT
+
CC?FFFDDHHHHHIGGGIIGIEHHGGJJIIGIJJJJJGIIIJGJJJJGIGEIIJEEF*?FCBHHGGEEF@EEH>7?BB7=>2@>35;>@@###########
@9CH
CTCAGAGAAAGAAACTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGAAACAGCACTTCTT
+
CCCFFFFFHGGHGJJIIJJJJJJJJJJIJJJIIIJIJJIJFHIGJIJJIIJJJHIJIIIIJGHIIE@GHGIDIGHAHHFFFFCCDD?CCDDDDDDDCCCCC
@9CI
CTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGGAGATTACCTGGGGCAATTGATGTTATC
+
BC?DFFFFDHHHHJJJJJJJJJJIIJIHIJIJJJJJIIJGIJIJJJJIIJJEGGGGHJGIJHGIIJIHIIHGFBDBCEEEEDDDDBDDDDDDDDEDECDE@
@9CJ
ATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATAACATCAATTGCC
+
C@CFFFFFFHHHHJJJIJJIFIBHGHIGIIJJJIIEIJJJJGIIJJJJBHHGGCHCCHHGGGCEBECH;@@>@CE?C>@CDEC>CB6888>ACCC######
@9CK
TTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATA
+
@@@FDDEFHHHHFGGIIIHHI<EGCBDEGDCGGGFAFFIECGGHJIGIECHEFG@DHGIJIJJIJIIHEEEHHHDFDBCC?@CD>B>C5;;;;3@AC?###
@9CL
GCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCA
+
CCCFFFFFHHHGHIBGGEHIIJJEHHG>FAGIHGFGIIJIJJGIFGIIJJFIHHFFFDDCEEEEDEEBDBDBCCCCCCD:@>CDDDAC?9@3<?:A3:?##
@9CM
GCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCA
+
===AA++<?;?=)<+?+??AAA0?A1=A>A>>=9AAB:4=8;=3=A;)=4=16/4=>@9>9>>>@####################################
@9CN
GCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCA
+
@CCFFFFFGFBDFGIJ;FHG>DHAFHIIGHCHDFGGHIIIIIIIJIJIJ>CAEHFFFC@AECCEFEEDDDDBCCC:ACCDCCCDCC@CD<5<8<>ACC182
@9CO
GATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCG
+
<1=?=;:?DHB?;EFHD7E1?B8?<?<BDBFDFFBFBC2B>BGE@==FEBA;.7A3?DEEDEECAA;>CCCCAAC:@>ACCA@CC>93<@@:ACBB#####
@9CP
GGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAA
+
@CCDFFFFHHHGHJGIJIJIJIIIJJJJIEGIGIIIIJJIJJJJJIJIJEHJJGIGCDDFFFEEEEDEDDDDCDDCDDD?BCDDDBDDBB9BDBDDDD><<
@9CQ
CCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATAACATCAATT
+
CCCFFFFFHHHHHJJJJJJGIJJGIHEGIIJJJJJJJIIIIJJJIIJJJJJJJJJJJJJJJJJJJGHGHHF;BCECBDEEDECCCDCCDBBDDDDDDACCD
@9CR
CTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATAACATCAATTGCCCC
+
=@@;BB=BFB?HDGIGGG;G:CFHCH9DHGGCHGIIFEH>GBFFAG<@ADHGGEGIIGGFCHGIIFHEDEBCDED>C>;AC@CB?=8?ACCCC:4:@3:@?
@9CS
GCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAA
+
CCCFFFFFHHHHHJJJIJJJJJJIJJJJJJJJJIJJJJJJJIJJJJJJIIHHIIIIJIJIJIIIJHGGFHFEDAECCDDDBBDDDDDDDDDDDDDCC@CD4
@9CT
CCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGCTAGTTATAGTCTGACCGATAACATCAATT
+
CCCFFFFFB?FCFIIGIJIIGGGGBAHII?FHHIGGIEGE<DIHFGDGGFHGGGGC=F>ACHFG@AHEEHE5;;A>;>A@;@AC(((-3,;02@C@C:>:>
@9CU
CTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCT
+
@?@?DDDDHADHDHEHIIGBHGCBHHIGIGGED@FHHIIDHIIGGEIAGDFG><BAHGEEHHEEACBB96=>;=?95@8AACC3::>9<8A?A<3@C@@C:
@9CV
GTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTAT
+
BB=DDFFFGGHHGJIJJJJJJJDIIHIJIJIFIJIIJJJJJJJJGIJGIIHGHHHFFFFFFFEEEEEDDCCCCCDDDCDDDDDCCDDEDCCDABDDDDCCD
@9CW
GTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGCAT
+
???;BBDDFHFFHGGB<E>FHGI?@FHHGGIIIGFHGIIDHG@GGHEGG=;ACEEEEBDDEC>>@>AA(>CCA;>9(,,>CC>ACCCCC>:498<?#####
@9CX
TGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTA
+
CCCFFDEFHHHHGJGGIJJJFIIJJ@FFHHGGIEIIIIIGHGIG<FH@EHAHHGHFF@CDDDECCEC@AAACCDDCBDDDCACCC>>A@B4:@AB?@>:44
@9CY
CGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGC
+
CCCFFFFDHHHHHGIIJJIIIJJJJIJIJIJJJIJIJJJJIJJJGHIJJJJJJJFHIJJJJHHHHHFFFEFCECC>CDDDCCBBD?>DDD@BD59CDDCBC
@9CZ
GCTGTCCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTG
+
@@@DFFFFFFDDHIGEIIJJIIEGIFIGIIHIHHEGEHGICGIGIJGDHIGHHHHFFFFFED>BCCEEDDDCDCCAC@ACCDDDCDDDDCDAAC@C??BCC
@9D0
GCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAG
+
CC@FFF@DHHHHHGGAE@BGGCGGIIIIIIGIGIIIC4BGEHIICGEGGGG)=7@;CH@EC?CBDFEE;ACECAC;@AADD@C/'085<@A@?@5<AC###
@9D1
GGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCT
+
@<?DDD>DDHDADCEBGGEHGGGIEICGGGGIGDFHE=DCHG=FGGBFBHEG;=?AD?@C;@CCD;6@C:;5@3>>:@CB?C?CCCCCC4>AB@CCC<?29
@9D2
TGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGC
+
?@@DDDBDFFHAF:C<B@F1CFEBEBDEHH8;@GHGGHDFHBFH>BFHII;B>ECDEDE:>>@CACCCCECCCACAACCC?CCCC@>>C::@C:AC>A@B?
@9D3
TTCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAA
+
@@@FFFFFHHFHHIEEGHJGHGEFHBGHGGGEGGCDHII<BFHIIGGIIEGHGGBEEHFFDCEEEEEDDCDEDCCACCCACCCDACBCACAC@:@CACEE>
@9D4
CGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGC
+
@;@D7@8A1C;A<?4<FBFI9CE)1)1?DB<?<BF<9DBFFFBFB@@CAB)6=F5)>CC;.766)=)..).6(;@@AB@=A@/23(5?A33<&)5???38<
@9D5
TAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTG
+
CCCFFFFFHHHHHIJHIGIJJJGIJIGIJGIJJIIJJJJIJJHGHHEEFFFEDEEEEDDDDDDDDDDDDDCDDCDCA?CB8?CCDEDDDBDDDDCC@CDAC
@9D6
GCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGG
+
CCCFFFFDHBHHGIIGJJJIJJGGJHGGHIJJG<FHIJIIJJJGGBHIBFEGHGGGGCHCHGGH@GGGHGIHIHC?EBCC9CDDCBB==AC9CACB9<<BD
@9D7
GCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAG
+
@@?DFDFFGHFHGJIGIIGHCEHIEHCCGHJIIIIJJJIGGHGEGGFF4CFHGEE5=CEHFEDEFFACACCC?C5;@ACCB@ABDD<<CCCDDD<@DDDDB
@9D8
GGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHIJJJJJJJJJJJJIJJJJEHIHHHEHFFDDA@DDDDDD=BDDCCDDD@BB
@9D9
CGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGC
+
CCCFFFFFHGGHHJJJIIIJJJJIIJJIJIJIJJJJJJJJIJJJJGJHIJJJIGHIIJJIJHHHHHFFFFFEEEEEDDD@CDDDDA@CCDDDD<@CDDCD<
@9DA
CCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTG
+
@C@FDDDEHHGHHGIIFIIIHJIJJIIIGIJIIJJIIIJGHHIIIGGDGECGHGJI;=CEEHFFDDD?BDAA:AC;ACCCDCCCCCC3A@CDDD?C>?A3:
@9DB
CCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTG
+
??8A?ADDFFFF3C@GFEG3FG@4?FAFEFFEFGFFCCGA;FG<@FF;8=C;=F(-@AAAACD6@8';=?@?A:@(:5(5@BB3:>:::@AB#########
@9DC
GGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCAT
+
C@@FFFFFHGGHHIIJJIJJJIHGIIIJIGIIJJIJJJJIIJJFIIGII=EHIGEHHGFDFCEEE@>?BDDBDDDDDDDCCDDECCDECCAACDCAC####
@9DD
TTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCC
+
@@1ADDFFGGHHGBAFEHIGEGJEHHDHBFGGCFHJIIAFHIJJFGHGAA8EEGHHFFEDDDCDECABBBDD=A??ACCCC>ACCA:>A@CACCCC3>A@A
@9DE
AATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGGGAA
+
@@@DABDBFDFFHIGGIHIJIIJIIEHD<F*CFHCFHIIIEIJIIBDGCHFHHGE@BF@DDHJJ;FGIDBE@AHB=?>CCAC;>8;?<9CBCB5?>B@<83
@9DF
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
@@@ADDFDDDFHHJIJGEGCG<GEAHHIEHIGGEGEHCHH;BBBFA?BF?8B9?DGECCDHGGIJIGCHIIIIHGH7?DAABDD359=BBCC?>?A@5?BB
@9DG
GCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCC
+
;@@FBDFFDFDFDE>FECHDE@AFBHIGIGBCG<BFH@D>B90B=FGFHC>C@FGGG@=CHC>;@DAC;;9;5;?9<@??2<<C809@55<8?BC@CA4:>
@9DH
GCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCC
+
@@?DABDDBCF?B@DF@<C3C@<AC1?8?F>GF>@3BDFHIGGHC8=))88C>C=DGAEH7AACDE:CC/>@((5,58<79??C?@&0<-<18?<@#####
@9DI
TGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTC
+
CCCFFFFFHGHHHFIJIJBD;FHHIJIJJGJGIJJJCGCGIIIIHIEGIJJIIIHICDEHHHGF@BDAC?BDC>ABDBDDD<?<CBDD>BD?BDDDCDDCD
@9DJ
CTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGT
+
CC@FFFDEFFHHFHIJDHI:CGHIIDIGIJJJJIIGGIGGD>FGH(BFE@FCAC;@EIE;EECF>CFC<<=??CC:?BBDBBBBDDD959B@<<?29>>C:
@9DK
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGCGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
==>AAAAA>AABC>3=<<7=3<A3++?2AC?AB:=4?BBBB??BBBB)=074==<7758A===AB>7=>A###############################
@9DL
CTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCA
+
CCCFFFFFHHGHHJJJJJJIIJJJEHHIJGIIJJJJJJJIJJIIJGGIIJHGIJJJJJJGGGHCDEFFFEDE?@DBBBCCDDBBBBDDBCCD<>>B38AB8
@9DM
CTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGACTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCA
+
?@@F?BFDFHHBHIHGGIEGHHEE:CGHGB@EHDB@GBDEGHF@BB)BFCHIIGGICH>@GEHE;BED@7;;=A??>@C:ABBABB<<8CCBD09<B?<?8
@9DN
AAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGGGA
+
<@;DFDBDB>DFDA@GEICGCHF@D@BCHBEEHBEEGFG9HFC@GB0?G<?DDA@D@H@F@F@@CFAHI@D=EC>B<69?CC;?@2;A#############
@9DO
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
;?<DDDBB4<DD:BEEE;:C<E+AAEC>FDEAEIBE*:??DD?DDI8?D?DDDD@?B2B>B@CC)=AD>7@A>;5.=<?@(93>;><;88<??:<??&89?
@9DP
GTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACC
+
B@?DDFFFGHHGHJJJIJJJJJIJJJIJJIIIIJCGHJJJJJJJIIJIIIJJJJJJJIIIGHHE>EHFBDFBCDECCDDAC?BBDBDDCCCBDDD?BBBCD
@9DQ
CGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGC
+
?@?A;DAAFHFHFHGIIDH>FFFGIIGE?GEIEHGHGGHDHIEGIAGGGGIIIH@;=DAEHHHHEHF@C@@@A;@;@CC?@####################
@9DR
CGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGT
+
=>;<22??CCC;@=0)@?)@AA)=507?=A??ABB>;7=(..=.>=AAA>A;>>77;;5..;5>;?=5;,,(,:5:5(598=?;88?9:3:??89??####
@9DS
GTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACC
+
BBBFFFFFHHHHGJJJIJJJJHIJJJJJJJJJIGEGHGHIIJJIIGIJJJJJJI@HBHIIIGHGHHHEFFFFDDD@CDDD?BDB@DD@:>>@DDB8<<BDC
@9DT
GGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGAC
+
BCBFFFFFHHHHHJJJJJJJJJJJJJJJJIJJJJJIIJHIIJJIJJJJJIIJIJHGHIGIF?EAHHD@@DFFDDA@ACDDDDDB='539ACD0<AB?@?BC
@9DU
GTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCACCCACCTTCCCAAACGCTCCAGACCACAA
+
@;@D==ADHHHHGIIIGGHG4AEFEEAHIIE9FFHGIIF<;D)?F1?AFGBFGIGCI@3=?EEBBCBBEEC@(.;;?35:>>A@AAA##############
@9DV
TATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAA
+
@@@FDDDFGFHHHJJIJJJJJJGJJIJEBFGHGIDGIIGB@G>GEBA89B;ACEDDDA?ABCCDB?:AC>@CCCAACACDCCDDDCDDCACDCB<9CDDCC
@9DW
AGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGAC
+
@@@?BD@DHH?DFABFGGH@HGIHH@@DFHE@E>GEGHGI<DB9BD(;=(-@EBB>@B3?CECCCC(5?5;@@;,(5>5<5558:?C<:?###########
@9DX
CTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGA
+
C@@DDDF@DHHHFAFGHIC<EGCGHGC@FE<GGIGIIIIIIGCGDFG<A;=CB8ABBB7@>C3@3;@CC?;ACC@>A>@CBBBBBCCCC@?+89@@BC>@:
@9DY
GCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAG
+
@<@FFFFFHHHGDA<FEF@BFBEI9FHIIIIIIGIIIADF@AHHG<@GIGHIIGG?EEAH;CEFDDE>A6;>?C@-;AACB@CBC@BB?A>CBB59?<C##
@9DZ
CGACGAGCAAAGGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGC
+
<<<@:(<5?)<):>>?>??>(<?<?<?>?1=9??>????;:>>??>;?>???99?9>33=>??@@><?>???#############################
@9E0
CAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTC
+
@@@DDDADADDHDBBGGIEEA?8@GGBFHA=F@=@@E;DHHEEE>B@BE@BCCA>>@C>C>CCCCCC5@>9<@8>@@>4>ABBCC::9@CCC:>@C:AB>>
@9E1
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTCGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
@@@D?>DDCB?DF@FEI9:A3A:3<B3CC?B<E*1:4*:D*:**?D??;FA<*9?8=BFBC=C######################################
@9E2
AGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAAC
+
@@@FDFDFFHGGHIJGGIIBHIJIIJJI?EFH?FHHJJJJIJJJIIIIIJJJJIJIJIGIIIJII>EHFFF>B@B@BBCCCDDDDDDCCCB<>:@AC@3>C
@9E3
CATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJIIGGGDG@GHJJJJJIJJJIGHGIJJGGDIIJJJIIGFFFACEFDDABBBDBDCDDCACCACDDA<8::@CA
@9E4
CTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCAT
+
CCCFFDDDFHHHGIJJBE>FFHIGHGIJEGIHGIIIIJIIIIGIDGHJGEHIGIICHGGHIGGJEHGHHHHFDFCDDCEDDCEDDB??@@DDBDCCD>C@:
@9E5
GTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCT
+
?=?DDBDDDFDFHIHGBGIEBHCG@EHG=EFH3FF9GFIEHCEBFHGHG>?@?@GBAHCHAAGDCHE?AACHEDFEFFCCCDE>@A@CB;;?@DB?BB@B>
@9E6
GTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCT
+
CC@FFFFFGHHHHJJJJJIIJJJJJJIIHHJJIIJJJJJJJJJJJJJJIJHIHGEIFHIJFGIFIJHHHHHHGFFFFFEEDDDEDDDDBCDC==AD<<<BD
@9E7
GCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGG
+
+:+A:A2<DDBA3EB::)1@1?60066?=88=8BC=7AC=CDI;;?AA777;@>AAAAA;A;>>AAAA?=?=(:;>>A:<><>>>>>AA3:>AD:>>>>;>
@9E8
GCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGG
+
CCCFFFFFHHHHHJJJJJJJIJJIJIIIJIJGJIIJJJJIIIJGIJGH?DFEIIIH@CHIJIHIJJIHHIIIGHF==B?=?CDACBB=?CCC:ACB5?><<
@9E9
ATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGTCGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGTTGGGA
+
8?@DDFDDH?FDFBFDGC<FAHAHHIICHC<E@FG:DDGGGGIIBHII0@5AGFDBAA>CE@@;>@CC?ACBBC>@CCACCCBCC>CC>A4>ACC######
@9EA
CCCAGGTGAGTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTG
+
CCCFFFDFGHFHHIIIIJJJJJJJJJJJFIJJJIIHIIJJJGHJJJJIJJJJJFHHJJJJJHIJIAEEHFFFFFFFFECEEEEEDDDDCDCDDCCDCBCDD
@9EB
CCTAGGTGAGTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTG
+
CCCFFFDEHHFHHGIJJJIJIJIJJJJJJJIIGIJJJJJJJIJJJJJJJJIJJIJJIIJJIFGIJHHGHHHFFFFCFFEEDEEEDDDCDDDEDDDDDD@CD
@9EC
GCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAG
+
@?<DDDD?FDHFFIBBFHH@?@GBDDGI@A<@E?FF@FGDBFCFHG@>FHEGGHHCHHHHEHEDED@ACCCCCCC@:>@CB@ABB><>CCC:?7)5?C?##
@9ED
CAAATGTGGCCCCAGGTGAGTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCA
+
@@@DFDDDFHHHHJJJCAHGHCHIIJJEHIIII@GGHHIIGIGGIIJ<BFGD>FGIGIGIJHGHGGGDGHIBEFFCCABA=ACDCDDEDDDCCDCDDCDD>
@9EE
GCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGG
+
@@@FFFFFHHHGHIIIHJIJJIJIGIJJJJJJIIJIFIIJJIJIJIJIHIHGIGGHHJIBHIIHHIGDHGGIJHCCBDC?@CDCDDB8=CD?CDCDDDDDD
@9EF
CAAGTTTACAATGTTCAAATGTGGCCCCAGGTGAGTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCT
+
CCCFDFFDHHGHHFHGHIIEHBEHIGHJGIJ:9FE??DGBHIJIGGGIJIJEIGH@FHGIIIGGCHCEFDEHIHHDEEHEHEFFFDCCDD?@?BDDCDDDD
@9EG
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
CCCFFFADHFHHHIIIIJIJDCHIHGDEGHB@EEIIIIJBHGG>FGGFH?;8?DD:EADA=F>F>A3=)7@ECA1..9B>(9=3@@A?28?##########
@9EH
CTCCCAGCAAGTTTACAATGTTCAAATGTGGCCCCAGGTGAGTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGGTTT
+
@;@BBDD?B:DCFGBHIBEHCBF>FCEH4AFGH?1?CD1?BFB9?:B<DHI90?F8DFH*==B88CHBC@CAD@;==C7=)?C@7;;@A:C@;98@#####
@9EI
CGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTT
+
=:@?BD:AC<<<DDBCBFHH3E;HEHHEEHIIGE<DFBGAHB@?BBGIHHG?BHABH<<CF@:=@>=CEHEBE>>AB>CBCB=B?C55(8?&+39>?C>BB
@9EJ
GGGCAAATGAGAACAGCAACATACAGCTGTCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTT
+
=;17?A+++22<2A7=@>=AA@=A?<A@+2*::=:<9?A7?;000=?=>A0=**9=BB25AA>=>BBBBBBB7=A;AA@@<==>??;9=6;===?=<;020
@9EK
ATGGGGCCTGACTTGGTGCAGGCTCCCAGCAAGTTTACAATGTTCAAATGTGGCCCCAGGTGAGTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTC
+
=?1DD?DD?FFHBBEF<:CEHBHCGGGGIICBDHAGHIIGIGGHGHIGGGB@<FFGIG@;.=DGHEACHECDE@DD@DEC@>@C;CAC;>AACCCACC9?>
@9EL
GTGATGATGTAAATGGGGCCTGACTTGGTGCAGGCTCCCAGCAAGTTTACAATGTTCAAATGTGGCCCCAGGTGAGTCATTATCTTCAGTTCAGACATGAG
+
?8:BDDDD<FDDFI@GE28@AGCGHFIB<EFCGF<CGFBEGECGE*9BDB@DF9BFB<CFCF@7.=CEI==??BB;?BAA>;>ACB>5(55@AB:@#####
@9EM
GCAATACTCTGTGATGATGTAAATGGGGCCTGACTTGGTGCAGGCTCCCAGCAAGTTTACAATGTTCAAATGTGGCCCCAGGTGAGTCATTATCTTCAGTT
+
CC@FFFFFHGHHFIJJJIJIIIIJJJJJJJFIIIJJJJGIJGGJJIIIJJIJJIJFFIIJIJIJAGIGCGGIIFEAABEFDDCCCDCCD@DEDAACDCCED
@9EN
GGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTT
+
@@@DDDDDFF?FFE;CFBGAAFHGFHDEGCI@FAF94:DG@F9BFA*09?(/9B??C8==FC33)@D@37@EE>=C#########################
@9EO
AAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGGGA
+
CCCFFDDDHGGHGJJJJIJJJJIJGIGIJIGIJHIJIGGIBHJJGHBGHIJGHHGHGIJIHHIJJHIEEHG==CB?>AA?AC:(8,8CDDABCB<<B@BBA
@9EP
GCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAG
+
CCCFFFFFHHHHHJIJJJJIJIJJGJIIJJIJIJJJJJJJJJJIIIGIIGIJJIJ;CHHHHHFFFFEECEDECDC>CDDDDDDDDD?@CDCDDD3<CDDD@
@9EQ
TCTGGGTGGTGGCTCAGGAAGCTATCCCTATTCTTATGCAAATAGTTGACCAAATCTCCATAGAAGCAATACTCTGTGATGATGTAAATGGGGCCTGACTT
+
=@1ADDDD<?CFFB>BFGA938<?@FC?CD3C>D9BF9<?B?BFE9?8B3/*=B=BB<=)=8=FHDE@;?CHFEA@?C@3));;6;;;@>;;(9'58?:@;
@9ER
CACCATTGTTTTCAAAAGATAAAATAACATAGCTCCGTGTGCTTTCATTAGCAGGGTTCAATCCAAAGATATCCAGCTCTTTCTTTGGCTTCTCTGGGTGG
+
@@CFDFFFFHHHHJJJJJEAFEGHFFHIIJJHFIJJJIIGIJJIIIBCIHIIIHGG9BFAEEGGAGGGIIIJJECEHHE>CCEFFFECCEACC;C@@####
@9ES
GCTTCATGTCCATGTAGTCACCATTGTTTTCAAAAGATAAAATAACATAGCTCCGTGTGCTTTCATCAGCAGGGTTCAATCCAAAGATATCCAGCTCTTTC
+
@@@DDDFFHHHDHI<FHHIIIAIGIIHIIIIIIIGHIIGIGIIIIIIIIIIIIIIGGGIIIIGEHIIGG3CGHI@@EHHHHHD@DDFCEAE@AC<ACCDD5
@9ET
CTTCTTATATGAGGCTGGACGATCATAGAGTGATCTCTGGATGTCGGAATATTTAGAAACCTCTTTCCTTTCTAGCATGGGGACATACTGTGTAGTATCAG
+
CCCFFFFFHHHAHIEEGHAAF@GHIII@9E?D@GEHGEIG@@DFBBG@FH)=@FF>=FD3=C7@>E@CCHFEA)7?3;@DBB;??>CCCDC>A(:;BB###
@9EU
CGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTT
+
CCCFFFFFGFHDHJIJGIJJJJIGIIJJJJJJJJIJJJJJJJIJFIJJIJJFHGBGHJJJJGGGIIJJJF?EEHCHDCC?<BABDCCABBB@CC?CBDB9?
@9EV
CGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGC
+
@@@FADDDFDAHHDHIICEBGFGGGFBFHIIGHCFGHCADDHCHIEAFGGCG>CF;CGGH>;?CF@C@@DFEC>C;>@@;CC###################
@9EW
CCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATAACATTAATT
+
@@@DFDFFHGHFHGEGHIGECHHGDHICHEHCGGGHIIHGIIJJIIIJIGIGIIJJJIIIJJJIIJIDHGFFFFFEEDDECEDEDCDDBDD@BCCD:ACCC
@9EX
GCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCT
+
C@@FFDDFHAHGFIJJIGIJGICHCCHHBFEH<AFGGIGIGDG@C>EGHIHECHHDEFF=ACEEE>5;??CDCC@@AC5@CCCCB>CB@@+0<@AD?B###
@9EY
CTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTA
+
CCCFFFFFHHHHHJJIGIIJIGJJJIJJJDH<@FHIIJJIIIGFHHHHFFFFEEEEEDDDCDDDDDDDC@CCDDD@@CCDDCD?CDEDEDDDDDDDDDDDC
@9EZ
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
>=>A<=A+<++22A<+2A===A7C727<+21*?@7@A7:A7?7?405>AA>4797?3..8.8)>BABBBAA4=A;>7=@######################
@9F0
CAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTG
+
CCCFFFFFGHHGHJJIJICGHIJIGJJGJJIJIIJJIJJJJJEI@DGIGIJHFHHFD7?DCAEEEEDBDDCDDDDDDCDDDDDDDDDB-+994@C@<5<??
@9F1
CGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCTGTCGCCTGCCTTCTACTCGGCT
+
CCCFFFFFHHHHGJHIJJJJJJIIJJJJJJJJJJJJJJJJJJHIJJJJJJIIIIJJHJIJFGHHHIGIIJIIJJIGHH>EEFFFFDDDEDDDDCCDD?@DD
@9F2
TGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATAA
+
CCCFFFFDHHHHGGIDHGIEFHEIIJJJJIHHIIGHIIIIJGJGGIJJIIIIIBGGHAHIIGIJJIJGGGFFHFB??ACDDDC>;@>;CDDA::A?#####
@9F3
CGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGT
+
CCCFFFFFHHHGHJJIIIJJJJFHJIIJBCDGGIIIIIJJIHIJIIHHHHHFFFFFFFEDEDEEDDDDD?CCC>@CCBDDDDDDDDDC@CCDCC@>CD###
@9F4
CGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTTCAAGAG
+
B@CDDFFFHHHHGJJIJJIJJIJIEHCEHIJJJJJJJFIJJJIJHGHFFFFFFECCEEDDDDDDDDCDDDDDDDDACDDDDDDDDDDDDDD<CC3>CCCDA
@9F5
ATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTT
+
@CCFFFFFHHHHHJJJJJJJJJJJJJJJJJJGIGIJJGIIIIJJIGIJJHFFCDEDDDDC>ACDDDDDDDCCCCCCCCDDDDDDDCDDDDDDDDDDCD<AC
@9F6
GTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCC
+
@@CFFFFFFHGHHJIIIJJIJJIIJJIJJGIBHGGGIIBGFHFGIFHHFFDAECEDDDDDDDDDCDDCDDDCCCD>?CCCDDDDCDDDDDDCC8AB<ACDD
@9F7
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
CCCFDFFFHHHHHJJJJJJGHHIJJJJJJJJJJIJJJJJJJJJJJJJJJHIJJJJJJJIJJJIIJJJJIJIJJHGHHFFDDDDDCDDB@DCDDDDDDDDDD
@9F8
TAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTG
+
CCCFFDFFGHHGGEIHHDGHDEHIII8GEGGJIIGIIIGIGIHHHHHFFEFECCCCCCDDDCCDDDDDDDDDDDDACBDD?ACCCDCD?<ACDCCDDDDCC
@9F9
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
@C@BDDFFFAFBFGIEHIIBDAGGAC@EHIGAEGGGIFE?FGEGIIIGGBDFHIIII@HGGIIIIIGGGHGGIDEHHBDBA@?CCCC@229?A>?9@@<9B
@9FA
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
@@@FDEFDD>>FH@DGGGGIDIJJIGHGHEGGIJIEGIEGJIGIHGGCGDGDDGHECFGIJGEGGCGA@DGHEHFHE<DD;8?CC>?=,8ACC@<A90?BD
@9FB
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
CCCFFFFFHHHHHIJJJJIIJIJIIJJJJJJIJJJJJIJJIJJJJJJJJBGIIJHHGJIGGIJIIIII@DHHHFHCCEFDA@DDDDBD@BCDCC1<@BDDD
@9FC
GGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTT
+
<<@DFFFFGGHHGIIBGIIJJHDH>CGIJIJJJIFGEHIGJIG>FIJGJJB?DDHE@GGFGGGFHEG@GEGGFEEFFCFDC?@CCACB?;?CCC><CDBB<
@9FD
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
CCCFFFFFFHGDHJJIIJJJJGIJJJJIJJJJIJJIJIJJIGDGHJIGHDFHIIIIJIFGCHHHIIIGHIJJIHHEEFFDDDCCDCBDBDCDCC?CB<@@B
@9FE
CAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGGG
+
@;?D7B?DDDFD;3?CFAABF3CFAFFBD+?4CFG9<?FF4BGF3BB0*99*98BF;C4CB@@)=F=DEE;;;)7:/,(3(5>A?2',5<9:??>>80?##
@9FF
CTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTG
+
?=?DDFFFHFFHHIIIFIIHIIEIIICCGIIIIGBDGHIIGGBGGIGGHECH?EH?DEFFB@ACA>CCAC@BDCD@CCDDCC@CDCCCA1<?CC>CDC@A:
@9FG
CTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCAT
+
C@@DFFFFDFAFDGGGGBHGDCCHEIGIIGG<FAFHIIGGCE=CHIGIDIEHIHHHEHHFFFFFECC>CC>;ADBCC;>A@DCC>>AADDCCC>:@CCCDD
@9FH
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGTAGCGTCTG
+
???DDD?D8DBD+C@+:<CC3+A<F@<<EB@<EEI<DDDI9B*000BD?)099BA*=BBC:ACC3877CEIE;;AA#########################
@9FI
CTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGC
+
CCCFFFFFFHHHHJIIIIIGEHIIEGGJIGHFEHGGGGHIIIIIGIIJJJGFGIIIGIJHHGHGHHGFDFDCEEEEDDEDCDDCDDDCDDED>;:@85?B<
@9FJ
TCGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGC
+
@;@BDDDFGDFHDIHIEFFHIJEGIIGG<HHJGGIEHGGGIIJAB9CHGICGHGIGGIEHFHHHFDF<D@AADD?ACAC>BCCACCC>>CCA@;CCC
@9FK
CCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCTGATAGTTATAGTCTGACCGATAACATCAATT
+
@@@=BD?D>F8+2AA?<EF3CBFGC+<A+2<A2CEFB@*??1CG*:?FFF;?6B6(=27=F@7@#####################################
@9FL
CCGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTC
+
@@@DDDADAF?FAGGFEHGGHGEHEBGHIGGGI@DEDEECHCEBD?ACCA>ACBCCCCCCCCCC:@C>A>B??<C>CACCCA??CCCC3>>>4:>CC3<>4
@9FM
GGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTG
+
:;?DDDDDDADD:::C;CA@+:FF4AA<?8?E?<BEF>DC@D@BD@D?BDEEE99/)88BCE@A87@C=7@AEDC3796'69>A#################
@9FN
CAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTA
+
CCCFFFFFHFFHHJGJJJJJJIJJIJIJJIJJJJJJJJJJJJJJJJJGIHGGIJIJIIJJIIJHHHHHHHHFFFFDFEEEEEEEDDDDDDDDDDDDDDCD:
@9FO
CCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTT
+
CCCFFFFFHHHFHJJJJJJIIJJIJJCGHIGJJJJIIJJGJJJIJJIJJHGHHHHFFFFFFDEDDDEEDDDDDDCACCCCCACCEDDCCABBDCDCCDE@@
@9FP
GGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTT
+
?@@<DDBDDFADAFD>FGHCHBEGBC@EGCHGIGI@<FFHDA>GCD<@FEHFHEHCCGGGHIBEDDD9C;CCCAC1A>69<?8?A@(<??BC<?:2?####
@9FQ
CGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAG
+
@@<DADD?FFAHHBFHHGIECGGIIGICE@?BDHGEGGIGG>@FGFFEGGGE@F-=4@>D4AEAA:;;7??C@;>6>@@15;638(09@C:<<&)39<:A
@9FR
CTTCAACCACCTTCCCAAACGCTCCAGACCCCCAGACCCGACCAAGCACTACTCCATCTCTTGGCAACTCCCATCTTGAGTCATCAGGCAGCTGTATGTTG
+
<@7;ADDD?:DFDDFGBEF+<E1@E**11?D6)8))?B;;6@FE;(;677?);?>DDCCC#########################################
@9FS
GGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATATCTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCT
+
BB@FDDDEFHHDHIIJJG@HHHIIIGIJJJJGIIHGHIJII>GHGIJIFHII@H@FGIIIGIDHHBBAABBBB5??@@CCCDCC?ACCDDDCDDDD#####
@9FT
GCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGG
+
?@+BADADHHFHFGG1C@EE:DHGBEGGHIIIGHIFGGIII<DEHEHFEDEECCCCCCCCCCCCC>ACB??55>@>>AA?BCCCACCCC>(:>@CC@A@B<
@9FU
CTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGC
+
;@@FDDDFFC=FDH>EHIEFGGHHCDHIIGGDFHIEHGHIC?BBCBGHIGECGDHIGGG@CEF@CACCB=53(6>;>;>>C@C>CCCCCDD:@########
@9FV
CAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGC
+
CC@FFFFFHHHHHJIJJJJJJJJJJBGIJJIIGJDIIIJIJIJJJIJIJIEGIJIHHGHFFFFFFFEDEEEDDDD@BCDDDEEEDDDCCCCDEDDDECDD
@9FW
TCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGT
+
@<@DDDDDD;FB8@EG;CHG<F:FFGHHGEA@DC=FGGIIIHHEE>C9;BEC@9ACCCAA@CCAA>>:3>A<?B(93>>AAA<?C3@@CA@CA(4>A>@##
@9FX
CTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAAATCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCG
+
=?8A4A==A:++AE>EEI:FE6D):D)0:?<?BDB*0?B?8?DD=))/=AADEIECA@D...7.)=7;@@DA>(.6@B3-5;;A>:>>3>:>3,5:?
@9FY
GGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGA
+
CCCFFDFFGA?DFGAGGIIFHEHBEHHEGGHIGIIIIGIIGHGIIGIIIIIGIBHIFDDDDBBBDDDCACDCCDDDDDDDCCDDDDDDDDDCCDDDDDAC:
@9FZ
CCGAGTAGAAGGCAGGCGACGGGCAAATGAGAAAAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGGTTCCAAGAGATTGACTAGTGCTTGGTCGGG
+
;;;?D+A=,ADA?D?))@:@8:?8@DD<D*8==)=8(8@8(.7;=C9C37?)3)773>;>A@AAAAA##################################
@9G0
CGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTG
+
@@@FDFDFGGDHGBEGIGI@CHG@HEDGIDHHGHIGGGEEIJJJI>FCHHGI9F;ADHHIJCEEECCDCCBCCC>>A@CB@;>=8?BDAC
@9G1
CCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCT
+
??@DFDFDHGGHDHJHJIIIICEFHGEHHGGIIIIIIJJJJGGGHGIIIJGGGIJIG<FHIIGEHHGHEHFFDF?@CEEEEEEECDCDD@?B@BDDDDDDD
@9G2
GTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGG
+
@@@FFF?DF;;D@GHGGEG>FBFFFG<B>FFHGGHGIDGGHB@@EHFEEHHHCDCDFCCEA@C@A?=;>>ADCCB??CC@94>C?:3@########
@9G3
GTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTT
+
@@@FDDEFGFFA??:@EF?<G@EBG<BDF<D>9CGGGEGIC;CHGGFE>CHCFFFF@;@>>>@AC@;?CDC@A><9<AC@C@AC>A3:CCC?AA#######
@9G4
CCACCCTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTC
+
CCCFFFFFHHGHHJIJGIJIIJJJGIIIGDIIIIHIGJIIJJJHJJIJIHHHHHGFFFFFDEEEECDDDDDDCC@@@DACCCDDDD?C>CCACDACCDC##
@9G5
CGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAG
+
?@@DD1ADFDAFBA2CE@GEHIIGIDFGIIFIIIGICGADGHIIFEIDH=)=@F5@DGGIHFEHEEE3BBD@36;;>3;?@CBBB<59>>:<><BACACA
@9G6
CCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCT
+
@<???;;DFHFHHIFDHEGG:EGFHG<D?00?DC9BDHGH<FFDHBBFHHHIICGC3)77@>:=AEBEB@C>:>CC6;;@C@ACD@>AD;(55>@?259?<
@9G7
CGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTACTCGGCT
+
CCCFFFDFGHHHHJGHJIIIIJIJIIIAHGIGIIJDHJJJIJJJJIJIIIJFJJIGHHGGGHIIJIGGEHIDHGBDEEEBDFCDB6A?BC>ACCDECB@78
@9G8
GGGAAGAACTGGAAACTCAGAGAAAGAAACTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCA
+
CCCFFFFFFHFHHJJJIGIJHDFGCEIIJJJIIIJJGFGIJJIGIJJJJJIJIJIEH>=BFGGCHHGIIJIIEFBEEEEECEB@CEC=?=ADDACB#####
@9G9
GAAGAACTGGAAACTCAGAGAAAGAAACTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGG
+
CC@FFFFFHHHHHJJIJJGJJJJ3CGHJJIJIIIIJIJJJJJJJIJJJJIIGIGIHGIIIJJIIJIJJJJJJDHEEHHCEFFDEFBBCDDDDCDDDD@BD<
@9GA
TGTAAACTCAGAGAAAGAAACTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGAAACAGCA
+
??1ADDDDBA?DFCEHGA?EBDCDHIGEEGDHIE<EDGAAHGBCEH>FE*BGCGGIIIGCGGA@@FICDE>E>CEC;6?2?;B@CCBC'39?C??CCC<<3
@9GB
TGGAAACTCAGAGAAAGAAACTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGGAGATTAC
+
CCCFFFFFHHGGHJJJIJJJJJJJJJJJIJGIJJJJJJJJJJJIGIHIJIJJJJJJJJIJJJJEHIJJJIGIGIIFHHGFFFEFEECD@BDDDBDDDDDDD
@9GC
CCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCT
+
CCCFFFDFHHHGHJJJHGHIJIGHIJJJJIJIJIIJIJJJJJAHGIIIIJJJJJJIJGHJHHHHHHFFFFDEEEEDEDDDDDDDEC>CDEDDDDD@BBDD9
@9GD
CTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGGAGATTACCTGGGGCAATTGATGTTATC
+
BC?DFFFFDHHHHJJJJJJJJJJIIJIHIJIJJJJJIIJGIJIJJJJIIJJEGGGGHJGIJHGIIJIHIIHGFBDBCEEEEDDDDBDDDDDDDDEDECDE@
@9GE
GCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAG
+
B@@DDFDDHDHHDGHIIGIGJJIIJJJJJGHGIIIIJGHIIEIGGIJBHHIEIE@FGGGHIIGIJHGGBDDCCADACCC@CDDBBDDDDDCCC5:::>A@:
@9GF
TTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGT
+
@CCDFFFFHGHHHIGIEIJJJHIJJGIGHGGHI@FEHIIIGIIJJIIGHEGIGFF@HCFCHIHHHGBFFFDCEAC;9=>:;@>3>:A(:::@CC#######
@9GG
CAAGACTGGGCTTCCACCGAGCAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATG
+
@@<DDDDD;D;CD;CFFIIE@?):C):8C@DGFCF>DDFF;;BDAE@BCCA;FE;@'?)=CDB);BD:;;@6669>?((:AA>9?B<>55&05<0<<?BBB
@9GH
CGAGCAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAG
+
CCCFFFFFHHGHHJJJJJJJIJJJJJJIJJJJIIJJJIIIJJGJJIJIIJIJJJJJJJIHHHHHFFFBFDD?BDD?BBDD@DDDCDDDACD@DDDDDDDD3
@9GI
CCCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTT
+
CCCFFFFFHHHHHJJJJJJIJJJJJIJIIJJJJJJJJJJJIIIJJJJJJIJHFHHHHFF:BCFEEEDECDDCCDDDDDDEDCC?ADDCC:ACDDDDCDDC>
@9GJ
CAAGTACTGCCTCCAGAAAAGCCAATTCAAGCGTTGGGAAGTGGCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATT
+
=@@DBDFFHHHHHJJJJJJJJJJJIIJJJIGGHHJJJJIJJGHIJGII7)8;;CGHE:C);BD<A;/;5<@CD>?CA@:ACCC:2<9:3(4:+<@B#####
@9GK
GCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCA
+
CCCFFDFFFHHA?DHGHGIGGIAGI?FHGGGGFHHIAGHIEHCCEGGGA>DAEEFDEFFEECCEEDECB==BCCCCACCCCCCCCCDCCCCB?BCCCC@B@
@9GL
GATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCG
+
@@@FFDBBHHG>FEBEHII>HGIAHGGIC<DGEBDCGE;CDEHEHIGDGG@CEFEHFED;BCDCC??8A>C>CC>:@C@CCC>A?B-528:4:@8??B@B@
@9GM
GATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCG
+
@?@DFDFFHHHHGIJGIJJIGHIIIJJJEGGIFEGIEHGJIIIJJIIEIIGHHFHHFFFFFC?ABDBDDDDDCCCCDDACDD@@CD7@B@CDC@?ABB@D>
@9GN
GGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGA
+
@@@DDDA;AF?FF@GDDHIIE@?<AA:EC?EE@B@@@GHIB<FGBD8DBB67;F@8@G7@D@CCHFEHH@@BA?,,;;-;A??8;B<5@955>-(8:@@@C
@9GO
TCAGTCTCAGACAAGTACTGCCTCCAGAAAAGCCAATTCAAGCGTTGGGAAGTGGCAGGGTCGGTATGGGGGGGCCGAATCCCCTGATCTAAGGAGAGTAC
+
@CCFDFFFFFHHHFECFFHHGJGIIBGCHIDIJIJEHIJJIIJIHHHGI@FG=CECGGE##########################################
@9GP
GCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGAAACAGCACTTCTTCTCAGTCTCAGACAAGTACTGCCTCCAGAAAAGC
+
CCCFFFEFHHHHHJJJJIJJJJIJJIIJJJIGGIJJJJJJJJJJJIJJIJJJIJJJJIHIJJJJIIHHHHGHFDFDDFFEDEDCCDECCDDDDDDDCC?CB
@9GQ
TGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACCGCAACATACCGCTGCCTTATGACTCAAGATGGGAGT
+
?@<DAAD?F>A:A8CF9F??FE>E>9C<<C>?::?)??FF<)?BHEF>;;@BB<A;555;;>;((3;'09@<@((&055<<>4>C::>>@C##########
@9GR
ATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCA
+
@@@DDDDDBHDFF@GGEGG;7AG@F;CDH@3CDHAGG9:DBHHC;FCCGHGEBHFFBDEEC>C@CCACC>A5(55>>3?AA:<CCACC:>:4:>>@:A:><
@9GS
CCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGG
+
CCCFFFDDHHHHHIGIHHGGIGJIJFIIIJGIEHIEHJGCDHIIGHAFGIIHHGIEFFFEEEEEE@CDCCDDDEDCCDDDCDDDDDDDDDDCDCCCDD@A@
@9GT
TCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAG
+
@C<DDFFFHHHFFEFIIBEHIIECFHDGGGICG@D@FH<GHGGCDDHGIIIIIIIIADD@DBEEDACCDCC>@@>AA@CCDDCCDAC@<@CA::>CCAC3:
@9GU
TAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTG
+
CCCFFFFFHHHHHIJHIGIJJJGIJIGIJGIJJIIJJJJIJJHGHHEEFFFEDEEEEDDDDDDDDDDDDDCDDCDCA?CB8?CCDEDDDBDDDDCC@CDAC
@9GV
CAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACT
+
@@1AD>DBHF=:<C>FHHHCGBEEHGGGHGHD:CEF<FEIGIIGI>?BD9DB@6;;FFGHG@@)@EFE;21/=/5;AC@@@C3@@@92582<5:(:C@34:
@9GW
GTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCC
+
CCCFFFFFHGHHGJJIIIJICGEHDHICGGIIJIGGCHHJJJJJJJIJJIIEIHHHHGFFFDDDDDDDDDBBDDDDBBDCDDCDDCDDDDECDC:ACCCDD
@9GX
GCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCA
+
CCCFFFFFHHHHHJJJHJJIJJJIJJJJIJIJHIJJGIJJJGHIJJJJIJJJHHFFFFFEEEFEFEEBB?BDCCD:CCDDCDDDDDEDDDDD<ADDDDDD?
@9GY
CAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCGACCAAGCACTAGTCCA
+
CCCFFFFFGHHHHJJJFGGGGGEHIJIJJJJBHGHGIJJFEHEGEHIJCCH@FEGI<C?CHEHEE89AABCDADBB@?BBB<9?B59@3A###########
@9GZ
GCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCA
+
CC@FFDFFHFHFHHIJGIJJIJIIJJJJIIIJIIIJIIIIGIGJIJJJJIJJHHFFFFFDEEEEEEEDD?BBCAA>CCCCCDDDDDEDCB5<?1>C>AB?<
@9H0
TTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAACCACCTTCCCAAACGCTCCAGACCCCAAGACCCG
+
CCCFFFFFHHHHHJJJJJJJJJJJGJJJJJJJHIIJJJJGIJJJJJJJIJIIIJJBGIIJGHHHDAHE>?DDEECEACCDD@?BDD@CCDDDDBDBAACD#
@9H1
GCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGAA
+
@8??DDDDHFHHFGGHGGIHGDGBEGCFGHIHBAGEGGGGIIFD9F;@@;=;BBE7C>;@;AB66>>?3;;=C(5:@ACC3::@@@3(()9>?<>A:@###
@9H2
GCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCA
+
@7@DDBDDAFHFHIEHEIGGAF<@FEEHIG@E>DGBA<C@FFFDGII9@;DAE<<;@@D;ACCCDA;2;;@89@C:C:@:>>CCCADCC555??A>CC@<2
@9H3
TATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAA
+
@@@FDDDFGFHHHJJIJJJJJJGJJIJEBFGHGIDGIIGB@G>GEBA89B;ACEDDDA?ABCCDB?:AC>@CCCAACACDCCDDDCDDCACDCB<9CDDCC
@9H4
GGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGAT
+
CCCFFFFFFFAHHJGIJIEGGHGIGHIJGIFIIIIHIJJGGDDHIJJG<FGGBHDGEDC;>BBDCCDC>>>?<CDAA?CCCC:::ABD<(:>@>A@C####
@9H5
GGAAAGCTTACTGTGAAAAACAAAAGAGGATACGAATGGGACTTGAAGTTATACCAGTAACCTCTACTACAAATAAAATTACGCAGGGAAGAACTGGAAAC
+
@@@FADFFHHGHGEBHHJGDHIIGJFGIICHGHGGHIGBG@GGG@DGIIIEGCHCGEIJ@@FHHIGCECDHBAHCEA?@B>BBCCB@8<<1<?CDD::::3
@9H6
AGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTCCTTCAAC
+
@@@FDFDFFHGGHIJGGIIBHIJIIJJI?EFH?FHHJJJJIJJJIIIIIJJJJIJIJIGIIIJII>EHFFF>B@B@BBCCCDDDDDDCCCB<>:@AC@3>C
@9H7
AGACATGAGAGCTTGTTTTTCACTGGATCTGGCCGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGGGACCGGCTTAATCCATAGGCTGTTC
+
@CCFFFFFHHHHHJJGIIGGJJJIJIIJIEHIJJJHHII@FHIJJGGGFHIIJEEGIGJHHGGHHHHGFEEF@EEBABBBDB@?@C@C@CCCCD:@@A<A:
@9H8
ATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGTCGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGTTGGGA
+
8?@DDFDDH?FDFBFDGC<FAHAHHIICHC<E@FG:DDGGGGIIBHII0@5AGFDBAA>CE@@;>@CC?ACBBC>@CCACCCBCC>CC>A4>ACC######
@9H9
CGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGCACA
+
@??DDFEF?FDDDGGIHIA>FEFD>HEAGIGIIIIIEDHIIBG9?BGA??BCBFDA=)==.@EGD=DEH85(;;;;>BB=?B@:3,59><BB?@C######
@9HA
GTTTTTGACTTCTGAGTCTAACATAGATTTCTTCTTATATGAGGCTGGACGATCATAGAGTGATCTCTGGATGTCGGAATATTTAGAAACCTCTTTCCTTT
+
@=?DD;DDDDHHHEEFGHGDHGHCEE+CFB?FHIGIGHC?@:CA=GH<???F@D:BCF>FCH=A@F>7=@@GEA)694;=>@36@@>;A;=??:@>C5:5>
@9HB
CTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTA
+
CCCFFFFFHHHHHJJIGIIJIGJJJIJJJDH<@FHIIJJIIIGFHHHHFFFFEEEEEDDDCDDDDDDDC@CCDDD@@CCDDCD?CDEDEDDDDDDDDDDDC
@9HC
CGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCTGTCGCCTGCCTTCTACTCGGCT
+
CCCFFFFFHHHHGJHIJJJJJJIIJJJJJJJJJJJJJJJJJJHIJJJJJJIIIIJJHJIJFGHHHIGIIJIIJJIGHH>EEFFFFDDDEDDDDCCDD?@DD
@9HD
CGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTTCAAGAG
+
B@CDDFFFHHHHGJJIJJIJJIJIEHCEHIJJJJJJJFIJJJIJHGHFFFFFFECCEEDDDDDDDDCDDDDDDDDACDDDDDDDDDDDDDD<CC3>CCCDA
@9HE
GTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCC
+
@@CFFFFFFHGHHJIIIJJIJJIIJJIJJGIBHGGGIIBGFHFGIFHHFFDAECEDDDDDDDDDCDDCDDDCCCD>?CCCDDDDCDDDDDDCC8AB<ACDD
@9HF
TAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGATGGGAGTTTCCAAGAGATGGACTAGTG
+
CCCFFDFFGHHGGEIHHDGHDEHIII8GEGGJIIGIIIGIGIHHHHHFFEFECCCCCCDDDCCDDDDDDDDDDDDACBDD?ACCCDCD?<ACDCCDDDDCC
@9HG
CCAGACCCCAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCT
+
CCCFFFFFGGHHGIJJIGIJGIJGEGHIIJJJIIJJJJJJJ>GGIIJJJGIIJJJIIEGHGHEHHHFFFFC@C@CDECDDDDDDDDCCDDD@CCDDBDBD@
@9HH
GGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCTTATGACTCAAGA
+
CCCFFFFFHHHHHJJJJJIHIJJGIJJIJIIJJJJIJJJJIJIHIJJJJJIIJIIIHFDDDDDDDDDDDDDDDDDCDDCCDDDDACDDDDDDDDDDDDCC:
@9HI
CAAGACCCGACCAAGCACTAGTCCATCTCTTGGAAACTCCCATCTTGAGTCATAAGGCAGCTGTATGTTGCTGTTCTCATTTGCCCGTCGCCTGCCTTCTA
+
CCCFFFFFHFFHHJGJJJJJJIJJIJIJJIJJJJJJJJJJJJJJJJJGIHGGIJIJIIJJIIJHHHHHHHHFFFFDFEEEEEEEDDDDDDDDDDDDDDCD:
@9HJ
GGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATATCTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGCTGCCT
+
BB@FDDDEFHHDHIIJJG@HHHIIIGIJJJJGIIHGHIJII>GHGIJIFHII@H@FGIIIGIDHHBBAABBBB5??@@CCCDCC?ACCDDDCDDDD#####
@9HK
GGGTCATTATCTTCAGTTCAGACATGAGAGCTTGTTTTTCACTGGATCTGGCAGTGGGTTTTAGCATCTTCACTGCAACTTTCATGACAGGTTGCGACCGG
+
@@@DDFFAFFDHHGI>EHE<EEGBFAFGE+<BEFDCA3FACACHH**BF@*9)009DC76B;.)8@@@E@>>E3=C=7=@@@C##################
@9HL
CTGGCGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTG
+
@BCF?DFFHHHHHJJJIJJJJJJJJGHIJJIJJJJJJJJDHIJIJJJJHIJJJJIJIHJIJJJHHHHHHFFFFFEECDDCCDDDDDDBDDDDD09?CDDCA
@9HM
GCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTG
+
CCCFFFFFHHHHHJJJJJJIJJJJJJJJJJHGIJIIHIJJJJJGIJJIIJJGJIJJJJJJJJJGHHHHFFFFDDDDDEDEDDDDDDDEDDEEDDDDDDDD>
@9HN
GGAAGATTTTCAATCTCCTCTTGGGTTGGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTC
+
@@BFFDFFHHHHGJJJJIJJJJJJJGIIIIJIJJDFGIIIJJJJEGGJIJGJJGHIGJGIIIIGHJJJJJGFBDFDCECDDDDDCDDDDDDDDDDDDDDDC
@9HO
GCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTG
+
@CCFFFFFHHHHHIJJJGIGJIJIIJJEHIGGGGGIGGGIGIJJJIIIJJJJJJIIJGIJIIJHHF>EFDFFDDDDDEDEDDDDACDEDDEEDDDDDDDDC
@9HP
CCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGT
+
@@@DADDDHHHHAGEHIBGIGIIIHIAHHIJIGCHGIJIGBGIGEG>FHFEGGHBGIGICHAFHGIIIJJIHHFHEFB>C(;@@CCDBBCBDB:8@DDCC4
@9HQ
GGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTAAAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGG
+
?@:B?BDDHBB<CGIGE3:ACCAH;FDB>B?C1?CGFGAHGGIGH@8?DGG*?=C=88BF>CGFD@E>)7=7=AECDC>DEC@C#################
@9HR
GGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGG
+
=@8BDDFFHHHFDHGIIGHIIJJIIJGGIIIIEFHIJHIDG@HHHI<@GEGGGDHHGIGIGIGGEHIGIGHFHFGEF@;@EEE@BD5:@CCCBDDDDDDD#
@9HS
AGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGG
+
@@@DDDDD;FDDFEBCCB+ACED@HEH<3EE@G@GHE=BGBGHE?FABFDCCFIID@FDFGI===EEHEEE>DDCEECCCCCCBCCC@CCBBBACCCCCB0
@9HT
GTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTG
+
@@@FFFFFHGHGHHEHGIJIJJJJBGHIJJFGIJIJIIJIJIGHIDGHIIIJJJJIIJI@DHGHGHHGACHFFFFCACCEECDDDDDDDDCDCCDDDDB>A
@9HU
GTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTAAAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTG
+
==>A=42+2AB<+<=2<7+?C+AC2AB?=<:A=4:==>;=B;=5A?A3=A<6=78)8.>>>7.=..==A;A?@;>>>@>>@@@??=5;=9,559?######
@9HV
CGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTT
+
@@@FFFFD?FFHFIIHIIJJJEIJFJICEHIGJJJIGHIIJIIIGEGDGIJJJJJIIJIGIGIGHHHGFFFFFBFEEEEEEEDDDDDBDDDDCDEDCCCD>
@9HW
CGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTT
+
@@@DDDD?<CFFACFHGGHGHHGGHDCHEHDDHIB*:DFHIGIH<DGHGIIGHIIEHGGCGGGHFAEFDEEEEEECCCDCCD:@CCCBBCCCCC@>CACCD
@9HX
GTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTG
+
CBCFFFFFHHHHCFHEGHIIJJIJHIJJJJIJJJJJIJJJJJJJJFGIIJIIJJJJJJIHIIJJJHHHCEEFCFFEEEEEEEDDDDDDDDCCDDCDDDDA>
@9HY
CGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTT
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJIJJJJJJJJJHHHHFFFFFFFEEEEEEEEDDDDBDDDDDDEEFDDDD
@9HZ
CCGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCT
+
CCCFFFDEHHDHHJGIGJJJJGIJIGIIIIEGHIIIJIGGGJJIIIJGJIGDHIHHHHEHFFFFFEDECEDDDDDDDCCCDDDDDDDDDDDDEDEDDDDDD
@9I0
TGATGAGTTAGAAGGAGGGGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAA
+
@@<DDAD?D?CFDDH>FG)<E8?3BBGBDCBDH@FG.BFCGEHDGDHIGAC7=;=<?'(6>ACCCACDEDAC>@(5;>?:?CCCCCCCCACCCCA@CC@@C
@9I1
TGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAA
+
??<ADDDAADDDDEIIEE+AB3CBFEDEEI@EBDDIDDEAEDEEDDE;B6BBDEIDIIDEDCECDD>CACDDDDDDDAAA@AAAA>AAAAAAAAA?AAAAA
@9I2
TGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAA
+
BBBFFEFFHHHHHJJJJJCGIHHJJJJJJJFHGIJJJIJJJJJJJJJJJJJHIJJJJJJJJJJJHEHHHHHFFFFFFFEEEEEDDDDDDDDDDDDDDDDDD
@9I3
ACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGG
+
CCCFFFFFHHHHHJJJJIJJIJJJJJJJGHIIHIJJEIIGJJIIIIIIJJIFHIIJJJJJJIIJJIJJIJIHHEABDDFEC@CCEECDECDDDDDDDD@AB
@9I4
TTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAA
+
5;5@(:).@44:;)=89;?<)89.2@5-9(18==?:7?709<>)<<:>??><<<?>?99>):=9?<?8;?@>?;9==?>=8=>>>==8;5;>6==:5=5::
@9I5
GTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTA
+
=@??DADDHFFF<EF:CAIFIIIII;FDFFHEFGH@?CFEGHIHGGHEGHGFBDFFDDF66//8CBHD;EEC>?CB@>@D>@@>A@AA?CCCACC@A?AC@
@9I6
CAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATATGCACTGTCACCCCTTCCTTGGCACTTTTTTG
+
@C@FFFFFGHHHHJJDFHIJJJHJJJJJIJIJJJJIJIJIJJJJJIJJJJJJJJHHGHHHFFFFDCDEEEDDCDDDDDDDDBDDDDDDDDDDDDDDDDDD<
@9I7
CCCGAGGGAAGGCAGGAAGATTTTCAATCTCCTCTTGGGTTGGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGC
+
CCCFFFFFFFHHHJGJJIJIIJJJJJJJJJJJJIJJJJJFFGIIJHIIFHIJHIJJJJHHHGHHHEFFEEEEEEDDDDDDDDDDD?BBDDDDDDDDDDDB>
@9I8
CTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTG
+
@@@DDDDDFHHFHGGHEG@HGEDBGFEGGGIIIEHBFFHEHHB6DCHIHEFI<@CGIGEFFAHEEGIFEHEEHECEFFFFCCEAECA==?B@C>:?CCCC:
@9I9
CTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTG
+
CCCFFFFFHHHHHJIJJJHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIIIHHHHHHHFFFFFFCEEEEEDDDDDDD@CACDDD>
@9IA
CTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTG
+
CCCFDDDFHFDFC?EEGHIIEHGIIIHAHGG?EAH@BEHHIGH7FFGGICGIIHIBHGIIIHIIHGGGHHHDEHFDFFDCCCE;;>ACCDDCC@C5>@CCC
@9IB
CGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAA
+
B@@FFFFFHHFHHJJJIJJIJJJJJIIJJJJJIJFIIJIGHJJJJEIIJGIJGIJIJIIJIJJJJJJGFFEHFHFHDFFFDE@CCEDDDDDDCCCDDCCA>
@9IC
CAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCAC
+
CCCFFFFFHHHHHJJJIJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJIJJJJJHHHHHHHFFFFEECEEFEDDDEDDDDEDCCDDB
@9ID
CTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTT
+
CCCFFDFFHGHHFIJIIJIJJIJIIJJJJEFGIJCGGHIJJJIJJJGIJJJIJJJJJJJIJIIIJFGEHHHHFFFFDECCEEEDDDDDCDEEDDDEDDDDC
@9IE
CTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTT
+
@@CFFFFFGGHHHJJJHJJJJJJJJJIJJIIJJJJJJJHGJJIJJIJJJJJJJJJJJJJJJJJIIHHGHHGHFFFFFFCEEDEDDDDDDEFDDDDDDDDDE
@9IF
TGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCT
+
@@@DDDFDHDFFHEGHIICGEHEHIJGIJ>DHIIGIEDHGIGDFC6DFFGGGGHCGG@HICEGEGGEHHGEH>=BB?CCDDB=CCCDDC5>@AD@CD@CC>
@9IG
TTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGT
+
BCCFDFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJIJJJJJJJJJJJJHHHHHFFFEFFFEEEEEEEDEDDDDDDDDDDD?
@9IH
TGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCT
+
BBCFFFFFHHHHHJJIJJIHJJJJJJIJJIJHIIJJJIJIJI?DHFHIJJJJJGCGIJIJHIIJJIGHHHHHFEFFDEDDBDDDDDDDD:>BCDCCDD>C3
@9II
TGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGT
+
BC@FFFFFHHHHHJJJJJJJIJJJJJJHJJIIIJJJJJJJJJJJIJJIJIJIJJJJJJJJJJIJJIIJIGEHHGFFFFFEEEEECDEDDDDDDDCBDDDDC
@9IJ
CAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCAC
+
CCCFFFFFHHHHHJJJIJJIIJJGGHJJGIJIIJJJIJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJJHHHFFHGFEFFEEEEEEEDDDEDDDDECDCDDB
@9IK
CCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTACCA
+
?@@DBDBB??DA;C3CB?I?E:GFH@@BC>G@?CF@?DBFHHAGBF?9?*9?D?BC@BF<FH@==38CG;7==C==C?;;?DBCC@6;;;=AB;?,99ACA
@9IL
CCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTACCA
+
@@?DDD:D?FDFDHGBGECHBGHGH>F41CBDDCC@@FD9BFD98BGH@HGCF<8@=C=<BGC=@=FE/=@=AC?=C@?;@CD>>CC(6;;5=?8(99A@>
@9IM
CCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTACCA
+
@@@DDFDDHGHHHHEHIIIIIGHHG>GHIFFABHHIIGIEA?<FAFEHHHGGHHHIGII4BFC=@FF3@;DEHFEEHCBDC);@CCEDE>?BA@@?#####
@9IN
CCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTACCA
+
CCCFFDFFHHGHGIIIJJJJJJ?GHGGHIGGGIIIJJEIIGJIIBGGHIJIEIIDHIJICHIIC=CAEGIHFGGHFEDFEEDDEEECCCDBBBBDDDDCC@
@9IO
TGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAG
+
CCCFFFFFHHHHHJHGJJJHIJJJJJIJJIIHJGHIIJJJIJIJJJJJJJJJJJJJJJJGJJHHIJJJJIJHHHHBBDCEEEEDDDDCDDDDDDEDDDCDC
@9IP
CTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTATAATACTTTGATTTCCCCACTTGTG
+
@CCFFFFFHGGHHIJJJJJJJJIIJJJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFF:BDFFEEEEEEDDDECECCDDDDDDC
@9IQ
GAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGC
+
@@@FDDFDHHHHHFJIGHIJIJIIJEEGGHEEEIGEIHIJIIII3BFHIIIHI2BDFIIIJECGGIGJJJGHHFEHHFEFFFECDC=AB?ACDDD?CBCDC
@9IR
GAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGGGGTAACCCTGGTGC
+
??@D4ABADHB?FEGDEFHGEHFIG?CECFACB<??C<CDGH?G:BFEEGB?@?FHEHGIHCC@CHCGGIIEHF>HEEEEEEECC<'9?0<(:>BAC?###
@9IS
TCCCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHEBDDFFEEEEDEEDDDDDDDDDDCBDD
@9IT
CTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGT
+
CCCFFFEFHHHHHJJIJJJJJJJJJJJHIJEIEGHIIJIGGHFHGI?FHHIIIHIJJJJIJJJJJJJJJIJHEHHHHEEEFFFFDDDD;AD>CCDDDDDD:
@9IU
CTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGT
+
CCCFFFDFHHHHHJJIJJIJJJJJJJJJIJGIEEHIIJJIIIGIIJDGIIJJJJJJJIJJJIJJJIJJJJJHEHEHHDFFFFFFEEDD?AD@CCCDDDDD:
@9IV
TCCCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTAC
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJHHHHFDEFFFECEEEEEDDDDDDDBDDCDDD
@9IW
TCCCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTAC
+
??;BBDDDFHHGDGBHGGHGIIGJHEHFHEIIJIGIJJIIJE>FHIIIIIDCBFCHHCCHEGIGIIHCGGHHHH;;;;@>CCEEACECCDCDDDD?=<<AA
@9IX
CCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGG
+
@@<DDFFBFDHFHIGFEEIEIHIIEHIDFG>?@?@FCHGGCHHCD@?BBEGHH@GG?FAHHGHIEIHHIIGFHGEA?>;;CCC>CA@AB,=??ACCC<A<<
@9IY
CCCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTACC
+
CCCFFFFFHGHHHJIGIHIJJJJGIJGHIJIJJJJIIJJJIGIJJIJJIJIIEIGJIEGIIIEIHIIIIHEHHEEFFFDFFFEEDDEDDCDDDBDD9ABD:
@9IZ
CCCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTACC
+
CCCFFFFFHHHHHJJJJJJJJJJJJIJJJJJJJJJJJIJJJJJGIIJJJJJIJJJJJJIJIJJJJJJJIJHHHFHFFFFFFFDEDEECDACDDBDDDDDD@
@9J0
GAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGA
+
C@CFFFFFHHFHFIIJJJIHIJIIJJIJJJJJIJIIJJJIIIIDIGIJJIIIGIIJIFHIJIIIIGIII@F@FGA@EGHHGFBE;>=AE??CDDDDD@CC;
@9J1
GTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATATTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAAC
+
<@@DDBDD:C>>FGHDBHHGIB;FG@>?D9FFGGHIHGGIBHD<DGHIH*?<C<FGABGGIIBHCG@DC;ECHEEHHED:?@DAC@CCCC>=;;@C@@DCA
@9J2
GTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAAC
+
CBCFFFFFHHHHHJHIJJJJIIIIJJJJJGJGHIJJJJIJJIJJIJJIIJJJIIJJJJGIJEIIIJJJIHHHHFHHFDFFFFFEEDEDDDDCDDDC:ACA3
@9J3
TACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTAC
+
@B@FFDFFHFHHHIJJGIJJJJJIAFHGIJJJJJJJJJJJIIJIJFIIJJJGHIIIJGIDGGHIGEGHIJGFHHHADFEFFFCAEECECDDDDDABB9?BD
@9J4
CTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGC
+
C@BFFFFFHHG>FGIGIGIGIGIIJJJJJJJIJGIIIIIGIJIJJGGCHGIIJJIIJJJGI@GACHGEHHHHFFFCDDFDEEEEDDEDDDDC>C<CCCDCC
@9J5
CTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGC
+
CCCFFFFFHHHFFIJJJJIHJJGIJJJGIFIJGHCHIIJJJBFHIGIIJGIGGGIJJJJJEHGCDEHEHHE>EEFE;@CCEDECDEEDDDCCA@CACCCC:
@9J6
CCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGTTACCA
+
@@@DB??BA:<<:?CEDB<CAD@?F@GH>CGD<DBDEHCH@B*90BBB?FE></*/=B8BFE>4C:=@E@7?)=7=77;@?;3>C@@>@@5;??B?#####
@9J7
GGGCAACCTGCTGATAGATGCGGAGGGCTGCACGTTGGGGATGCTATTTTGGCAGTCAACGGAGTTAACCTAAGGGACACAAAGCATAAAGAAGCTGTAAC
+
CCCDFFDFHHHHHIJIJIJIIHJEHIJJGIGGIIHIGJJJCFHIJIIJJJHHFHFFFFFEDCBDDDDEDDDDDDDDBBDBCBBDCDDDDCDCBDDDDDCD>
@9J8
CTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTT
+
CCCFFFFFHHHHHJJJHIIJIJHJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJJJJIJJJJHHHGHGHFFFFFFEDEEEDDDDCDEDEDDDEDCDDD
@9J9
TGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTAGCACCAGGGT
+
BB@FFFFFHHHHHJJJJIJJJIJJJJJJJJGJJJJJJJIJIGIJGIJIIHIIHIJJJJJJJJJJJIJJ@GIHHHFFFFFFDEEEDEDDDDDCCCDBDDBBC
@9JA
TTCTCCTCCTTAAGGAAGATCATGAAGGCCTTGGCATTTCAATTACAGGTGGGAAAGAACATGGTGTTCCAATCCTCATCTCTGAGATCCATCCGGGGCAA
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJEGHJJJJJJIJJJJJCHHHIHHHHHHFFFFFFEEEEEEEDDDDDDDDDDDD?
@9JB
CACAAAACTGTGATCCGAGCCTGCAGAGGACGTAATGACTTGAAACGACCAATGCAAGCACCACCAGGCAATGATCAAGATTCCCTAAAGAAAAGCCAAGG
+
=@@FDFFFGHDFFFGDHHIII@GHIJJI7?DHFEGGGGIGIJJGDHGGGFHGHA?CHH9@B;?=?CD=A(;>AA;(5::@C@CDA5>CC>38A<>BA??B<
@9JC
CCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGA
+
;:?DDADDAFDFAG+AEGEFEHGHC;+CEHGGHBGGGDEG?FF4?BEGGDFGH@AFGGEHGCGFGIHEDCACCH:?CDAB>>3;ACB=5:??=@#######
@9JD
GAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAA
+
?@@D=BDAHHHFHGHICDHIHEIJIJJJIJIIJIGGGHIGIGGHIIGGGIJHIGGHHJEGFHIJJIFJGEECHDEDFFFFDECAA@CCDBB@CCCDCBDB9
@9JE
CTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTGGTTGCAAA
+
?;?DDDD8A:C4CBE2<??:AA<CED4<?4FFE**:?CDD990):8?@@?DE1==4<=@)4@)=@@;4=477?D><@D>>A####################
@9JF
CTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGGGTTAGAAGGGGGGGGTAACCGTGGTGCTAGTTGCAAA
+
1?@??BD??D>FFFFABFD:,<CABFH<CF9C<?*1?*:9CGG:BDDGF/7?BBBFFED78)=).=CD>=;=C############################
@9JG
CCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAA
+
@<?DDFFFHHFHHIIJIIJGEHHDHIICCDHGGIJ?FFGIIHHGGIIGIGHCHGIIIHFGG@>EH::BEDFE);>A@ACDBCC?>CACCC?CCC:ACC4@3
@9JH
ATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTACTCTTC
+
8=@DDDDFDFFDFGBFBHHIIGHIIIIIEGGIGEGII)?F@BGCHHGHI?FCDAABGHGFHGGHIIIGEF?ADFDBCDCCCCCD;;B:;>AC@(5;>>CCC
@9JI
GTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCTCCTCTTGGGTTGGAAGAGTACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAACTA
+
=?7?DDDDADDDDE1?@6EF>E3)C?:?@??DEI9D>EDDDE<;CD<@D;@ADDEDC>7?@DB@A@A36>>>AAAA(;(;>>==?>A>35:AAAAADA>A>
@9JJ
AGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGG
+
@@@DDDDD;FDDFEBCCB+ACED@HEH<3EE@G@GHE=BGBGHE?FABFDCCFIID@FDFGI===EEHEEE>DDCEECCCCCCBCCC@CCBBBACCCCCB0
@9JK
GTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTG
+
@@@FFFFFHGHGHHEHGIJIJJJJBGHIJJFGIJIJIIJIJIGHIDGHIIIJJJJIIJI@DHGHGHHGACHFFFFCACCEECDDDDDDDDCDCCDDDDB>A
@9JL
GTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTAAAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTG
+
==>A=42+2AB<+<=2<7+?C+AC2AB?=<:A=4:==>;=B;=5A?A3=A<6=78)8.>>>7.=..==A;A?@;>>>@>>@@@??=5;=9,559?######
@9JM
CGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTT
+
@@@FFFFD?FFHFIIHIIJJJEIJFJICEHIGJJJIGHIIJIIIGEGDGIJJJJJIIJIGIGIGHHHGFFFFFBFEEEEEEEDDDDDBDDDDCDEDCCCD>
@9JN
CGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTT
+
@@@DDDD?<CFFACFHGGHGHHGGHDCHEHDDHIB*:DFHIGIH<DGHGIIGHIIEHGGCGGGHFAEFDEEEEEECCCDCCD:@CCCBBCCCCC@>CACCD
@9JO
GTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTG
+
CBCFFFFFHHHHCFHEGHIIJJIJHIJJJJIJJJJJIJJJJJJJJFGIIJIIJJJJJJIHIIJJJHHHCEEFCFFEEEEEEEDDDDDDDDCCDDCDDDDA>
@9JP
CGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTT
+
CCCFFFFFHHHHHJIJJJJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJIJJJJJJJJJHHHHFFFFFFFEEEEEEEEDDDDBDDDDDDEEFDDDD
@9JQ
CCGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCT
+
CCCFFFDEHHDHHJGIGJJJJGIJIGIIIIEGHIIIJIGGGJJIIIJGJIGDHIHHHHEHFFFFFEDECEDDDDDDDCCCDDDDDDDDDDDDEDEDDDDDD
@9JR
TGATGAGTTAGAAGGAGGGGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAA
+
@@<DDAD?D?CFDDH>FG)<E8?3BBGBDCBDH@FG.BFCGEHDGDHIGAC7=;=<?'(6>ACCCACDEDAC>@(5;>?:?CCCCCCCCACCCCA@CC@@C
@9JS
TTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGT
+
CCCFFFFFHHHHHJJJGFHIJJJGHIJJJIJJJJGIGIJJGIJIJIJIIIIJJJJJJJIJJJIJJIIJFFHHHFFDDDFFEECEECEDDDEDD@DBCCDDA
@9JT
TAATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAA
+
8(0@@@?@@@@@)2=@@<9@@@?@??@@<>>????????????????????=>?????@@@@@?>9>???>??<=????>???>?>>>??>====7<====
@9JU
TGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAA
+
??<ADDDAADDDDEIIEE+AB3CBFEDEEI@EBDDIDDEAEDEEDDE;B6BBDEIDIIDEDCECDD>CACDDDDDDDAAA@AAAA>AAAAAAAAA?AAAAA
@9JV
TTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGT
+
=?@DBDDDBHFDFGHG>FG>ECFCHDHECFHIA?BEEDF@BFFHIIIB;=B<CFCC=@FF;==7=CEGHFE777@B:@?3;>CCC6>;@;3>?C89>C:@5
@9JW
CTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTG
+
CCCFFFFFHHHGHJJJJJJIJJJJJJJIJJJJJJIIGIJJJJJFHIIIJJJJJJJJJJIJJIIIJIJHHHHHHHFFFFFFDEEEEEEDDDDDDCDDDDDD@
@9JX
TGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAA
+
BBBFFEFFHHHHHJJJJJCGIHHJJJJJJJFHGIJJJIJJJJJJJJJJJJJHIJJJJJJJJJJJHEHHHHHFFFFFFFEEEEEDDDDDDDDDDDDDDDDDD
@9JY
TTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAA
+
5;5@(:).@44:;)=89;?<)89.2@5-9(18==?:7?709<>)<<:>??><<<?>?99>):=9?<?8;?@>?;9==?>=8=>>>==8;5;>6==:5=5::
@9JZ
GTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTA
+
=@??DADDHFFF<EF:CAIFIIIII;FDFFHEFGH@?CFEGHIHGGHEGHGFBDFFDDF66//8CBHD;EEC>?CB@>@D>@@>A@AA?CCCACC@A?AC@
@9K0
CAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATATGCACTGTCACCCCTTCCTTGGCACTTTTTTG
+
@C@FFFFFGHHHHJJDFHIJJJHJJJJJIJIJJJJIJIJIJJJJJIJJJJJJJJHHGHHHFFFFDCDEEEDDCDDDDDDDDBDDDDDDDDDDDDDDDDDD<
@9K1
CCCGAGGGAAGGCAGGAAGATTTTCAATCTCCTCTTGGGTTGGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGC
+
CCCFFFFFFFHHHJGJJIJIIJJJJJJJJJJJJIJJJJJFFGIIJHIIFHIJHIJJJJHHHGHHHEFFEEEEEEDDDDDDDDDDD?BBDDDDDDDDDDDB>
@9K2
CTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTG
+
@@@DDDDDFHHFHGGHEG@HGEDBGFEGGGIIIEHBFFHEHHB6DCHIHEFI<@CGIGEFFAHEEGIFEHEEHECEFFFFCCEAECA==?B@C>:?CCCC:
@9K3
CTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTG
+
CCCFFFFFHHHHHJIJJJHJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJIJJJIIIHHHHHHHFFFFFFCEEEEEDDDDDDD@CACDDD>
@9K4
CTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTG
+
CCCFDDDFHFDFC?EEGHIIEHGIIIHAHGG?EAH@BEHHIGH7FFGGICGIIHIBHGIIIHIIHGGGHHHDEHFDFFDCCCE;;>ACCDDCC@C5>@CCC
@9K5
CGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAA
+
B@@FFFFFHHFHHJJJIJJIJJJJJIIJJJJJIJFIIJIGHJJJJEIIJGIJGIJIJIIJIJJJJJJGFFEHFHFHDFFFDE@CCEDDDDDDCCCDDCCA>
@9K6
CAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCAC
+
CCCFFFFFHHHHHJJJIJJJJJJJJIJJJJJJJJJJJJJJJJIJJJJJJJJJJJJJJJJJIJIJJJJJHHHHHHHFFFFEECEEFEDDDEDDDDEDCCDDB
@9K7
ATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCAT
+
@@@FDFFFGHFHHBFIIIIIIHIF>HHH>FIIIGIGI)BB:BGCEBFHI9BD9CHFHIIEHIIEGHAEHF=A@DCCCCCCCCCC5;@5;>CCAA3;:CCC:
@9K8
ATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCAT
+
BB@FFFFFHHHHHJIJJJJJJJJJIIIIIJJJJJJJJDHIFHIJJJJJJFHIJJJIJJJJJJJJJJJHHHEHFFDDDDDDDDDD;CDDEDDDDCDEDDDD:
@9K9
ATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCAT
+
??=DADDBF?<A;?ABFGHIGHGEGGIIDA<FEGIIGIBF:?<FHIIID8?BFBC==4@GG@G=CHEHH2..)69?AA;>>>C@;;@AC3>5(::>5?@C#
@9KA
CATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCA
+
@@@FFFFFHFGHHJIBFHGHHGEHIGHHIHIIIHEGII?DGDHEHIJJJJGIIJIJHEGCCHIIJIJGF?E???DDD>ACDCCDC5@DCDDCDD:AACCCC
@9KB
CTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTA
+
BB@FFFDDHHHHHJJJJJJJJJJJJJJJJIIJIJGHIJJJIHIJJIJGIIIJJJJIJHHHHHFFFFDDEEEDDDDCDDDDDDDDD@DDEDEDDDDDDDEDC
@9KC
CTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTT
+
CCCFFDFFHGHHFIJIIJIJJIJIIJJJJEFGIJCGGHIJJJIJJJGIJJJIJJJJJJJIJIIIJFGEHHHHFFFFDECCEEEDDDDDCDEEDDDEDDDDC
@9KD
CTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTT
+
@@CFFFFFGGHHHJJJHJJJJJJJJJIJJIIJJJJJJJHGJJIJJIJJJJJJJJJJJJJJJJJIIHHGHHGHFFFFFFCEEDEDDDDDDEFDDDDDDDDDE
@9KE
CTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTA
+
?@?ADDDD<FAADBHGDFHIGEDH>GGGIBGGG@FDHIIIICGGHHGIIEHEIIDG@E>EHACEDECCCCCCACCCCACCCCCBB@@CCACCCC@@CCDA>
@9KF
TGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCT
+
@@@DDDFDHDFFHEGHIICGEHEHIJGIJ>DHIIGIEDHGIGDFC6DFFGGGGHCGG@HICEGEGGEHHGEH>=BB?CCDDB=CCCDDC5>@AD@CD@CC>
@9KG
TTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGT
+
BCCFDFFFHHHHHJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJIIJJJJJJIJJJJJJJJJJJJHHHHHFFFEFFFEEEEEEEDEDDDDDDDDDDD?
@9KH
TGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCT
+
BBCFFFFFHHHHHJJIJJIHJJJJJJIJJIJHIIJJJIJIJI?DHFHIJJJJJGCGIJIJHIIJJIGHHHHHFEFFDEDDBDDDDDDDD:>BCDCCDD>C3
@9KI
GTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTC
+
BBBFDFFFHHHHHJJJJJJJIIJJJJJGIJGHEGCGHIIJGII?DH@GHHIJJJJGHGGIIHJJIJJHHHHHFFFFACEDDBDDCDDDDDACEDDDCDCA:
@9KJ
GTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTC
+
@@@DDDDDBHDFHIG??FDFBFE@AD>94CEFHEBDCHIIDGI?DH@DFHGIGGHC@CGGD7@=A@CHHHFFDDB?>AAA?=@BAAACCA>CC@@CCCCA>
@9KK
GTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTC
+
BBCFFFFFHHHHHJJJHIJIHIJIJJJIJJGIHIIJJIJJJJJBGHGHIIJJJJJFHIJJIHIIJIIHHGHHFFFECCEDDDDDDDCDDD@ADDDDCDDC>
@9KL
NTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTC
+
#11<A=;=BA?CBAAACABA@BCBBA<@BB@A?AA?AA?;AAA85)0>A?==BBB=A4>AA>ABABBAAAAA3;@>(5;=:===??>=?????=??????;
@9KM
AGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTAT
+
CCCFFFFFHFHHHJJJIJJJJJJJJJJIHJJJJJIJJJIIHIIJJJJJJJJ?FHFHJJJJJJIHIJHHHHHHFFFFFEEEEEDD@CDDDDDDDDDDDD>CD
@9KN
GTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGA
+
@@CFFFEFHHGHGGIIHIEHCIGCGHHGHIJFIIIIJJJHGIJIJJIJJEGDHIJEHIJFHGC;CBGHJHHHHFEBDEDEEEEEECCDCDDDDBB>ACDDD
@9KO
NTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGA
+
#1:BBD=DHHHHHFIIEGHIAIGIICHJJGHIGIIJJJJGGIGIGIIJJ@EBGHIIJJGHIJ;CHEEHHHHHHFCDFFEEEEEEDDDDDDDCD?A:CCDD@
@9KP
CAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCAC
+
CCCFFFFFHHHHHJJJIJJIIJJGGHJJGIJIIJJJIJJJJJIJJJJJJJJJJJJIJJJJJJJJJJJJHHHFFHGFEFFEEEEEEEDDDEDDDDECDCDDB
@9KQ
AAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGT
+
@@CFDDBDHHHAFHEFHG>DHGIHI3CF<FFBGHFGGIIIFHIIIGIIEHIECHFHEHDHHH;@@GG5=A5?BEEDDC;;>>A;AACD@CDDCDDD??5A#
@9KR
AAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGT
+
@@CFFFDDHHHDFGIJJJIIJIGGICHIIGHJJIHHIJIJEHIJFHFHJIIIIJIJIIIJJJJJIHG5AHA@CDCDFECCEDDDDDEDDCCDDDDDDDDB#
@9KS
TGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAGTTGCAAAG
+
CCCFFFFFHHHHHJHGJJJHIJJJJJIJJIIHJGHIIJJJIJIJJJJJJJJJJJJJJJJGJJHHIJJJJIJHHHHBBDCEEEEDDDDCDDDDDDEDDDCDC
@9KT
CTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCTCCTCT
+
CCCFFFFFHHHHHJJJJJJJJJJJJJJJJJJJJJJJJJJJJEGHIIJJJIIJJIJJJHIJJHIIJJHHFEFFDDDABDDDDDBBD?CDDDDCC(,:>CCDD
@9KU
CTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTATAATACTTTGATTTCCCCACTTGTG
+
@CCFFFFFHGGHHIJJJJJJJJIIJJJJJJJJJJJIJIJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJHHHHHFF:BDFFEEEEEEDDDECECCDDDDDDC
@9KV
GGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCAC
+
@@@DFFDD?FHHDGIAGADH<BHGDGEEGH@;E?8;C?FFFGDHD0@?@@GCGGGEHHGAH6?@BD>;A>CCCCCCCC>ACC@?5:?A:@CC@CCC?C>AC
@9KW
GTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGCTAG
+
@@@FADFFHGFHGBH@EGEIIIIIIECEBAHDAGIGGGABFHGI<:?FCGHIIJGGGGE==CG>FGECDD@E3?AAE>@DD=C=?ABACCDA??<@CCC##
@9KX
GAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGTGC
+
@@@FDDFDHHHHHFJIGHIJIJIIJEEGGHEEEIGEIHIJIIII3BFHIIIHI2BDFIIIJECGGIGJJJGHHFEHHFEFFFECDC=AB?ACDDD?CBCDC
@9KY
GAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGGGGTAACCCTGGTGC
+
??@D4ABADHB?FEGDEFHGEHFIG?CECFACB<??C<CDGH?G:BFEEGB?@?FHEHGIHCC@CHCGGIIEHF>HEEEEEEECC<'9?0<(:>BAC?###
@9KZ
CTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGG
+
CCCFFFEFHGHHGJJIJJJJIJJJJJJGGIGIHHIJJGIIIJIIIIBGHIJJIIGHIJJIJJIJIIJJFJJHEHHHHFFEFFFFEEDD=?B>CCDDDDDD#
@9L0
CTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGGT
+
@CCDFFFFHFHHHJIEHGHIJJIJIEI;FHFI?EHDHIGGIIIJJIBDHGIJIGIJEHIIGFHIGCHHGECCCEEHGFDEDCEFCECD;;@>ACDDDDDD5
@9L1
CCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTGGTAACCCTGG
+
@@<DDFFBFDHFHIGFEEIEIHIIEHIDFG>?@?@FCHGGCHHCD@?BBEGHH@GG?FAHHGHIEIHHIIGFHGEA?>;;CCC>CA@AB,=??ACCC<A<<
@9L2
GCAGGCATTAGCCAGGCCTACTTCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTT
+
CCCFFFFFHHHFH:EGGIIIII<HGIIIIIIIIFIIIIIDIIIIIIGEG(@GHEHEHHHGHHFFDDDDEEEECCDCC@;CCDBDDDDDDDDDDDC?@CDD9
@9L3
GATGTCCACTGCTGTTCCTTCATACACTTCTCCAAAGGCTCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAA
+
BCCFFFDEHFHGHJJJGIIJJIJJJJJJGIIJIJJJJJIJGGIGHIGHHDFGIIJJIIJIIGGIJEHHHHHHHFDDEFCDBDBB?BBDDBBDDD@CDCDDC
@9L4
ATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGT
+
@@@FFDDDFADHFHDGGACFG>DGGBEGGFEEHGHI?CCFG>G>GIIIGG)98)??BBGHIIEGD=CAA8=CEGHHC1?C??BBC=C?BDDCCCA;>@;:>
@9L5
GAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGA
+
C@CFFFFFHHFHFIIJJJIHIJIIJJIJJJJJIJIIJJJIIIIDIGIJJIIIGIIJIFHIJIIIIGIII@F@FGA@EGHHGFBE;>=AE??CDDDDD@CC;
@9L6
TGGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCA
+
CCCFFDFDHDDBFFGHFIAIEFHGGGEHIGGIIIIG?GGGGCEHHIGGD@GDE@FDCGG@BEBBCBD;>>A>=C;@@CC@CCCCB?C@BCEACCC<>?@A:
@9L7
GTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATATTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAAC
+
<@@DDBDD:C>>FGHDBHHGIB;FG@>?D9FFGGHIHGGIBHD<DGHIH*?<C<FGABGGIIBHCG@DC;ECHEEHHED:?@DAC@CCCC>=;;@C@@DCA
@9L8
GTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGCAAC
+
CBCFFFFFHHHHHJHIJJJJIIIIJJJJJGJGHIJJJJIJJIJJIJJIIJJJIIJJJJGIJEIIIJJJIHHHHFHHFDFFFFFEEDEDDDDCDDDC:ACA3
@9L9
GAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGAATGAAGATGAGAGTGGACATCGTTACCGTTTGTAC
+
===AA+<;+??ABB@BBB3?@=37,<,<?3?CAA@BBBB*:**:7?:?*:?BABAB?9>A=A95=).=AB###############################
@9LA
CTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACT
+
?@@DDDDDFDBF>GHG?FHH9BHACCFEEDGGEGFIA3BBBBB4BGDEGGAFHCHH<GA@@D=C@BDED>BCDC@@CCC@C@@DECCCCB@AA@55;>C@C
@9LB
CAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATC
+
BCBFFFFFHHHHHJJJIJJJJJJIJJIJJJIJJIJJJJJJJJJIJJIJJJJJIJJHHHGHDFFFFDFEEDEDDDDDDDDDDDDDDCDDDDDDDEDEDDDCC
@9LC
CTTTCTCAGCAGAGAGGAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACA
+
?@CFFFFFHHHHHJHIJGIHIGIIJIIJJJIIJJEHIGHIIGIHIJJJJJEIIGI?DHHGIIJJFGHGIIHIJIJHEEHDE;?CCEEEECDACCCCCDCA@
@9LD
CAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTG
+
CCCFFFFFFHHHHJIDIGGIIIJIFJIJJJIJJEIIJIIJIIGHIJIIJIIEIIHHGHEHFFF;@A@CEEEDDDDDDDDDCDDDDDDDCDDDDDDDDDDD@
@9LE
CTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACT
+
CCCFFFFFDFHHHIIJJJJIJJJJJJJJJJJIIJIJIJJJJJJIJIIJJJJJJIJJIJJJJJJHHGHGFFFFFFDDDDDEDECDCDDDDEDDEEDD@CBDC
@9LF
CTTTCTCAGCAGAGAGGAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACA
+
@CCFFFFFHHHHHIIIIFIGHFHIJJJJJIJJJJFGDGIIJJJJJJJJJJJJGHIFHIJJJIIJJJIJJGHGIJJHHHHEF@DEFEDEEEEDDDD@CBDDC
@9LG
CTATTCTTTCTCAGCAGAGAGGAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGT
+
@@?DFFFDAFHHGGGEIGHCFHBE?FCFHIIIIIIHGHHDHHBGGIIIDGHHGIGIG<FGB=@>FAFEIE>ECDDDHE=EHDDB?C(;>>ACDA@######
@9LH
CAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTA
+
CCCFFFFFHHHHHJJJIJJJJJJJJJJJGIJJJJJJIJJJJCHJJJJJJJJJJJJJJJJJJJJJHHHHHFDCDDDFDEDDDDDDDEDCDEDDDDDDDD=AD
@9LI
TCCACTTCCCAGCAAGAGACGCAGAGTCAGTTTTTCCCGAGGGAAGGCAGGAAGATTTTCAATCTCCTCTTGGGTTGGAAGAGTATGTATTGCATAGCAGG
+
CCCFFFFFHHHHHJJJJJIJJIJJIJEHIJIIJJJIJJIHJJJEEHJJJJJHHGHEFFFFFFEDEEEDDDDDDD<?BDDACBD4>ADCDDDDDDEDDDA><
@9LJ
GTAACTATTCTTTCTCAGCAGAGAGGAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGA
+
@@@FFEFFHGFD?EFHGIJEHDGCEHFFEDGHGIIGGGGGIHGBFHDG?BFGFHIIJIGJJ@BD8C@CGDAGG@@CGECC>CCDD;@>=36>AACA@@;@3
@9LK
AGAAGCTGTAACTATTCTTTCTCAGCAGAGAGGAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATG
+
CCCFFFFFHGHHHJJJHIJJIJJJJJJJHIGIJDHFHHGIJGIIIJ9FHIHIHIIJJJIIJJIJIJIJGIJCCHEGHHHHEHEFFFFFFEED>BBDC5>CC
@9LL
ACAAAGCATAAAGAAGCTGTAACTATTCTTTCTCAGCAGAGAGGAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAA
+
@BCFFFFFHHHHHIJIJJJJJJJJJJJIJJJIJJJJJJJIJHIIGI@FEHIJIIJJJJIIJCHGCCEGIGGIJIJHHHHHHF?DFFCEECAADDEEDDCDC
@9LM
GGGACACAAAGCATAAAGAAGCTGTAACTATTCTTTCTCAGCAGAGAGGAGAGATTGAATTTGAAGTAGTTTATGTGGCTCCTGAAGTGGATTCTGATGAT
+
BCCDFFFFHHHGHIJJJJJJJJJJHICIJJIJIJJJJJIHIIHGGIHIJGH?FHHIIIIJJII@GHC@GCGGCHHEHHGFFFFFACE;@C@CCCDECDDD3
@9LN
CCGGGCTTTACGCAAATAAGTAAGAAGGTCTCCTCCCTCCATCAGTTCCAGGATAATGTATTGGGGTTCATTCAGCAGACAAACTCCAAGCTGCTTCAGAA
+
?BBFFFFFHHHHHJJJJJJJIIJJJJJJGHHJJIJJJJJJJJIJJIIIJJJJJJGGHIGIHJJJJHBDFFFFFEDEDDEDDDDDDDDDDDDDDDDDDDDC@
@9LO
CTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGC
+
C@BFFFFFHHG>FGIGIGIGIGIIJJJJJJJIJGIIIIIGIJIJJGGCHGIIJJIIJJJGI@GACHGEHHHHFFFCDDFDEEEEDDEDDDDC>C<CCCDCC
@9LP
CTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTTCCCCACTTGTGTCTTTGC
+
CCCFFFFFHHHFFIJJJJIHJJGIJJJGIFIJGHCHIIJJJBFHIGIIJGIGGGIJJJJJEHGCDEHEHHE>EEFE;@CCEDECDEEDDDCCA@CACCCC:
@9LQ
CTGATAGATGCGGAGGGCTGCACGTTGGGGATGCTATTTTGGCAGTCAACGGAGTTAACCTAAGGGACACAAAGCATAAAGAAGCTGTAACTATTCTTTCT
+
@@@BDDDEFFAHHIIGIIIGIIEHCFHIII?DB@GGHG@H<F3);===CEH:DB,6@>;CCDCCCBB@D?<?<C?C>@CCCA89>:@::@CC>@@:B>::4
@9LR
CTGATAGATGCGGAGGGCTGCACGTTGGGGATGCTATTTTGGCAGTCAACGGAGTTAACCTAAGGGACACAAAGCATAAAGAAGCTGTAACTATTCTTTCT
+
CCCFFFFFHHHHHIJJJJJJJJJJJJJIJJHHIJJJJJJJJJJJJJJJJJHHFFFEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDCCDDEEDDC
@9LS
GGGCAACCTGCTGATAGATGCGGAGGGCTGCACGTTGGGGATGCTATTTTGGCAGTCAACGGAGTTAACCTAAGGGACACAAAGCATAAAGAAGCTGTAAC
+
CCCDFFDFHHHHHIJIJIJIIHJEHIJJGIGGIIHIGJJJCFHIJIIJJJHHFHFFFFFEDCBDDDDEDDDDDDDDBBDBCBBDCDDDDCDCBDDDDDCD>
@9LT
CTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCACCCCTTCCTTGGCACTTTTTTGATTCTTTAATCTTCTATGCCAGACTTGTAATACTTTGATTT
+
CCCFFFFFHHHHHJJJHIIJIJHJJJJJJJJJJJJJJJIJJJJJIJJJJJJJJJJJJJJJIJJJJHHHGHGHFFFFFFEDEEEDDDDCDEDEDDDEDCDDD
@9LU
CTTGGGTTGGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGC
+
CCCFFFDFHHFFHGIGGHIIJJIJIIJIJJJJFIGGHIJJJIJJIJHGIJJJIIIGIIIHHHHFFFFDDDDDCDDDDDDBDCDDDDDDDDDDDDDDDEECC
@9LV
TGGAGGCCTTGGCATTTCAATTACAGGTGGGAAAGAACATGGTGTTCCAATCCTCATCTCTGAGATCCATCCGGGGCAACCTGCTGATAGATGCGGAGGGC
+
BB+ADFDDHDHHHJJJJIJJIIIJJJJ?FHIIDDGIIGIIJI?D;FGGFGHIGGGIGEIIEGGG@G;EEEE?E?BDBBBBBDDDC>@AC>>>CCB.09@D0
@9LW
TTCTCCTCCTTAAGGAAGATCATGAAGGCCTTGGCATTTCAATTACAGGTGGGAAAGAACATGGTGTTCCAATCCTCATCTCTGAGATCCATCCGGGGCAA
+
CCCFFFFFHHHHHJJJJJIJJJJJJJJJJJJJJJJJJJJJJJJJIJJJJEGHJJJJJJIJJJJJCHHHIHHHHHHFFFFFFEEEEEEEDDDDDDDDDDDD?
@9LX
CACAAAACTGTGATCCGAGCCTGCAGAGGACGTAATGACTTGAAACGACCAATGCAAGCACCACCAGGCAATGATCAAGATTCCCTAAAGAAAAGCCAAGG
+
=@@FDFFFGHDFFFGDHHIII@GHIJJI7?DHFEGGGGIGIJJGDHGGGFHGHA?CHH9@B;?=?CD=A(;>AA;(5::@C@CDA5>CC>38A<>BA??B<
@9LY
GGAAGAGTATGTATTGCATAGCAGGCATTAGCCAGGCCTACTCCGGCTGCCAGACCTCGCAGCTCAGCCAACTCTTTGTCTTCGTTTATAAGCACTGTCAC
+
@@?DDDD:C:B??B@EEHIIABF@FCAFHCF9:C;CDAF?CG<?BFDDF=@FDA@@@FC@=B>D@DEACA3=C>CCC@CCCCC?9A@?A@CCAA?CCC@:A
@9LZ
TTATGTGGCTCCTGAAGTGGATTCTGATGATGAAAACGTAGAGTATGAAGATGAGAGTGGACATCGTTACCGTTTGTACCTTGATGAGTTAGAAGGAGGTG
+
8=@DDDBDFFDHDABG@A<FCGEHIIIIG<FC9?CHGI8CD;DFG<DFEIC94BDB<?4;BCAC;;===5=A?AC1?CDEEC>@A:;(>@###########
@9M0
GAGGTGGTAACCCTGGTGCTAGTTGCAAAGACACAAGTGGGGAAATCAAAGTATTACAAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAA
+
?@@D=BDAHHHFHGHICDHIHEIJIJJJIJIIJIGGGHIGIGGHIIGGGIJHIGGHHJEGFHIJJIFJGEECHDEDFFFFDECAA@CCDBB@CCCDCBDB9
@9M1
TGCACAGTCTCAGCAGGAGAGCCAGGCCAGAGCCAGCAAGAGGAGACTCGGTGACACCAGTCTCCTGTAGGGACAGGAGGATTTTGTGGGGGTTCGTGTC
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9M2
GCACAGTCTCAGCAGGAGAGCCAGGCCAGAGCCAGCAAGAGGAGACTCGGTGACACCAGTCTCCTGTAGGGACAGGAGGATTTTGTGGGGGTTCGTGTCA
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9M3
CACAGTCTCAGCAGGAGAGCCAGGCCAGAGCCAGCAAGAGGAGACTCGGTGACACCAGTCTCCTGTAGGGACAGGAGGATTTTGTGGGGGTTCGTGTCAC
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9M4
GTGTCACTGTGAGCATATTGTGGTGGAAACTCATACGAGTTAAATGGGTGCCAGTGTTATTTACTCTTAGCCAATATAGCTCAGCTGGGCACTGTTTTGA
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9M5
TTCGTGTCACTGTGAGCATATTGTGGTGGAAACTCATACGAGTTAAATGGGTGCCAGTGTTATTTACTCTTAGCCAATATAGCTCAGCTGGGCACTGTTT
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9M6
GTCACTGTGAGCATATTGTGGTGGAAACTCATACGAGTTAAATGGGTGCCAGTGTTATTTACTCTTAGCCAATATAGCTCAGCTGGGCACTGTTTTGACC
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9M7
CAGGAAGATTGGATTAACCCTCACAGCTTCTATTCCCCGGGCCCCTGATACTACTACTACTACATGGACGTCTGGGGCAAAGGGACCACGGTCACCGTCTC
+
CCCFFFFDDHGHGIEIIIJJJIJJFIGIIGHEHGIGIJIJFGHIGCCFIJIGGGIJJHFHGFGFFFFFFDDDDBDCBB?BBAC?AD<?BBB<?@AAB?<BC
@9M8
GGAGGATGCACTCCCTGAGGAGACGGTGACCGTGGTCCCTTTGCCCCAGACGTCCATGTAGTAGTAGTAGTATCAGGGGCCCGGGGAATAGAAGCTGTGAG
+
CCCFFFFFHHHHHJJJJJJJJJIJJJHGIJIJBGIHIJJIJJIJIJJJJJIJJIJHHHHHHBCEEFFFFDCEEEEEEDDBBDDCDDBBDDDBCDDCD@CDC
@9M9
GGACTTTCAGAGCACAAATGCAGGATCTTTCTCCAGTACGTGACGGAAGAATTTTAGGTGTTCTTTTGCTTGACAGCAGGAAGATTGGATTAACCCTCACA
+
@<?:ADDDDB?A3<?A?:ACIBB?F<CCCH<FAGFIGBG;FC):??F6?8BBF8=8=7C;858@=ED=@=?.(.)76@D25@@?>AA?:;,:>AB29?###
@9MA
CCCAGACGTCCATGTAGTAGTAGTAGTATCAGGGGCCCGGGGAATAGAAGCTGTGAGGGTTAATCCAATCTTCCTGCTGTCAAGCAAAAGAACACCTAAAA
+
CCCFFFFFHHHHHJIJJGGJFHJGHIEHIJJGJJJJJJJJJJGIHIGIJJJHHHHGFFF?BDEEEEDDDDDDEDDDDDCDDADDDDDDCD?B?CDDDDDCC
@9MB
CAGACGTCCATGTAGTAGTAGTAGTATCAGGGGCCCGAGGAATAGAAGCTGTGAGGGTTAATCCAATCTTCCTGCTGTCAAGCAAAAGAACACCTAAAATT
+
CCCFFFFFHHHHHJJGFH@HHHGEIGEHHJJIIFIJJAGIIJJIJIIIJIIHGGHJJEEHGEFFFFFDECEDDEDDCCDCDDDDDDCDBBCDCD?ACADDC
@9MC
GGTCCCTTTGCCCCAGACGTCCATGTAGTAGTAGTAGTATCAGGGGCCCGGGGAATAGAAGCTGGGAGGGTTAATCCAATCTTCCTGCTGTCAAGCAAAAG
+
@@@A?:DDBBDDB?:ACEACCE1CCG?FF9C*1?1??1*:0BFGE>@?@F@A<5?B>B@>>A:>(;=;8=5<<(;:AB>@BBBAAA:::@>A:AB:<AB##
@9MD
CGGACGTTGGGTGGTACCCAGTTATCAAGCATGCCAGGACCACAGGGCTGTTATCCTTTGGGTGTCTGCACCCTGATATGATGGGGAACACATCCGGAGCC
+
@<@DDDDDHFF::A@FHGGIECAAGGGEGCGCFG9G3DFGGGGGDHIIFB@EEHEEEAEEH:?>CCCCD@;3=?A3>>;@>>;@9085?B??CCD>95@@#
@9ME
CCGGGCTCTAGTGGCCAATGGTCCATGAGCTTGATTTTCAGAACTTAACTGAAAGTAACTGAAGCTCACAGCTTCTATTCCCCGGGCCCCTGATACTACTA
+
CCCFFFFFHHHHHJJJJJJJJIJJJJJIJJJJIJJJJJJJJJJJIJIIIJJJJJJGHIJJJJJJJJJJJJIJHHHCHHHFFFFDDDDDDDDDCDDDDDDDC
@9MF
GCCTGGCAGATGAGCTTGGACTTGCGGGGGTTGCCGAAGAAGCCGTCGCGGGGTGGGACGAAGACGCTCACTTTGGGAGGCAGCTCAGCAATCACTGGAAG
+
CCCFFFFFHFHA8FGHIII<BFEHGHIIIIBBD@>AB>8BCDD<@5579<BDD)5<B88;50<-+50;;5@ACCCA<<?B<7??CA>C>A?@CA@CDD?>>
@9MG
TCTGTGCCCTGCATGACGTCCTTGGAAGGCAGCAGCACCTGTGAGGTGGCTGCGTACTTGCCCCCTCTCAGGACTGATGGGAAGCCCCGGGTGCTGCTGAT
+
CCCFFDFFHFHGGIGJIJJJGIJJJJGIIIEGIJIDHGGGGIIIIIDBBGGHGI@EHG@EHEEDFCDDCEDDDDC?>ACDDCDD@9?BBB<&0<ACD####
@9MH
TTTTAGAGTGTTTTTAGGTTTAGAGCAAAATTTGCAGAAAGTACAGAAAGTTCTTATATATCCTCTCCCCAGCTCACAGCTTCTATTCCCCGGGCCCCTGA
+
@BBFDFDE=CCFHIGIJJFGIGHJIBHHIHIIIIJIJIEHIGHDHFHFFHFHIIGIJGIGIFHIJIJJJJIEIJIIHGHHHFFFFFFCEEDDDDDBBD?@9
@9MI
GTTTTTAGGTTTAGAGCAAAATTTGCAGAAAGTACAGAAAGTTCTTATATATCCTCTCCCCAGCTCACAGCTTCTATTCCCCGGGCCCCTGATACTACTAC
+
==8ADDFFHFDHHBGFAGIJGIJJHGGHIBB@?CEFGIGHF*?DGGGIHIJJFGIBBHEIGIGIGGGFDGIGGGGEEHEHHE433',88A5?CCD@#####
@9MJ
TGCTGATGTCAGAGTTGTTCTTGTATTTCCAGGAGAAAGTGATGGAGTCGGGAAGGAAGTCCTGTGCGAGGCAGCCAACGGCCACGCTGCTCGTATCCGAC
+
@@CFFFDFHHFHFICGEHIDGIJJGIJJGIIJJFI?GEHHJJGIJIJHHFIJIIIIJIIEGIIJJJJHGHF@DDD?BDDBDD3905<B@<C><58><C?##
@9MK
CTTGTATTTCCAGGAGAAAGTGATGGAGTCGGGAAGGAAGTCCTGTGCGAGGCAGCCAACGGCCACGCTGCTCGTATCCGACGGGGAATTCTCACAGGAGC
+
:?+=ADDFHHHDHIJBDFGG<CHIIEGE<CFHGGIJIHHGBFGIIJIGGHI<@GEFGGFFFDDDBBDDBBBCC<5<CDC?(5@><-09A>C:(:>:A8AB#
@9ML
CCCAGGAGAAAGTGATGGAGTCGGGAAGGAAGTCCTGTGCGAGGCAGCCAACGGCCACGCTGCTCGTATCCGACGGGGAATTCTCACAGGAGACGAGGGGG
+
CCCFFFFFHHHHFHIJJJJJHIJIIIJIJIIJHIIGGHIIJJJJIGIIIJHHGFFDBBBDD=?CDDBDDDDDDDBDDDDBDCCC@>ACCB??1<?5>@DB5
@9MM
CCAGGAGAAAGTGATGGAGTCGGGAAGGAAGTCCTGTGCGAGGCAGCCAACGGCCACGCTGCTCGTATCCGACGGGGAATTCTCACAGGAGACGAGGGGGA
+
C@@FDFFFFHG<DGEIJGGADEGIDHGGIGGIIJJIFHIIGHIGIIGCGIAEHFDDDDD>BDCCBBBCBCD?>B><>>>BC@CCD>CCB8???BBBB@<B@
@9MN
GTCGGGAAGGAAGTCCTGTGCGAGGCAGCCAACGGCCACGCTGCTCGTATCCGACGGGGAATTCTCACAGGAGCCGAGGGGGAAAAGGGTTGGGGCGGATG
+
@@@DFFFFHFDBDGEGIGD<BAFGH0BFGAFD(BFH/@GBBHF6;CE?;>;6=?>@?B;7<ACCC3>CCCD<@(8505<B@B<9ACC??++9>BB######
@9MO
CGGGAAGGAAGTCCTGTGCGAGGCAGCCAACGGCCACGCTGCTCGTATCCGACGGGGAATTCTCACAGGAGACGAGGGGGAAAAGGGTTGGGGCGGATGCA
+
@C@FFFFFGHHHHJJJAHGIJJJIIJGJIFIGHFGGFGIIIIIGGBBFDFD?CDDDBDBACCEDEDCD@BDD@B9<>BBDB@BCC?@2<<BDD@@B#####
@9MP
GGAAGGAAGTCCTGTGCGAGGCAGCCAACGGCCACGCTGCTCGTATCCGACGGGGAATTCTCACAGGAGACGAGGGGGAAAAGGGTTGGGGCGGATGGACT
+
@@@DFDDDFACDHJGHGIGGIJJJCEDH@FFGGICHGIGIIDGEHFECBECABDDDB?A@C::>CCB?B?@B>><>BD3&29>??A@55<59<>>9909>4
@9MQ
GCAGGATCTTTCTCCAGTACGTGACGGAAGAATTTTAGGTGTTCTTTTGCTTGACAGCAGGAAGATTGGATTAACCCTCACAGCTTCTATTCCTCGGGCCC
+
CCCFFFFFHHHHHJJJJIJJJIJJIJJIIIIJJJJJJJJGHHIJJJIJJJJJJJJJJJJJJJJJIJHHHHHHFFFFDEDEDEDDDDCDDEEEEDDBBBBDD
@9MR
TTGAGAGCAAAATTTGCAGAAAGTACAGAAAGTTCTTATATATCCTCTCCCCAGCTCACAGCTTCTATTCCCCGGGCCCCTGATACTACTACTACTACATG
+
:?14BBDFHHGHHJJJJJJJIJDHGGJIJJJJIIJIJJIJJJJJJJJJJJJJJJJJJJIIIAHHJJJJJJGGIJ>DBCDDDDDC<@CCDDCDDDDDDCDD@
@9MS
GGGGAATTCTCACAGGAGACGAGGGGGAAAAGGGTTGGGGCGGATGCACTCCCTGAGGAGACGGTGACCGTGGTCCCTTTGCCCCAGACGTCCATGTAGTA
+
CCCFFFFFHHGGHJJJJJIHIGIJJJJGJJIIIJIIIJJHFDDDBBDCDDDDDDDDDDDDDDDD;ADDDD>BD?CABCDDDDDDDDDDDB<BBDDDEDED:
@9MT
GAATTCTCACAGGAGACGAGGGGGAAAAGGGTTGGGGCGGATGCACTCCCTGAGGAGACGGTGACCGTGGTCCCTTTGCCCCAGACGTCCATGTAGTAGTG
+
@@@?DADDBFFD=B;2?F:E@DFAGIEGAFFF@;4;@A?=;66BAABB?B93+38(2<??B;(2:>5@?BBB>@>:@>>:A?<??################
@9MU
GGAAACCCCACAGGCAGTAGCAGAAAACAAAGGCCCTAGAGTGGCCATTCTTACCTGAGGAGACGGTGACCGTGGTCCCTTTGCCCCAGACGTCCATGTAG
+
@CCFFDDDHHHHHJIJJCHHIIJJIIIFGGIIJBFGIJJIEGAFBDBFADGICIJJJJIGEICHHF?D=>@ABDBD@CDDCCC::@8?BBDB?>B@>>:A>
@9MV
TGAGGAGACGGTGACCGTGGTCCCTTTGCCCCAGACGTCCATGTAGTAGTAGTAGTATCAGGGGCCCGGGGAATAGAAGCTGTGAGCTTCAGTTACTTTCA
+
@@@FFDFDDHHFHEHEEGA<HHIIGHICFGHHDGGHHFGIJGIJICCFHIIGCEG=CCC@@=D>B>><@DB;;9@(:CA?CCCCCCDCDDDDDCCCDA>@:
@9MW
GTGGGAACTGTTTAGAGATGCGGTTTGGGGACTTTCAGAGCACAAATGCAGGATCTTTCTCCAGTACGTGACGGAAGAATTTTAGGTGTTCTTTTGCTTGA
+
@?@BDDFFHDHHHJIIIIIIIGG@FHGGIIA@GGIGGEGGIEIIJJBGIIIIGCIGJIJDGIHF?EFFCFFDDC;?>ACCCCCDDC>CABACCDD>@C>@8
@9MX
GCGGATGCACTCCCTGAGGAGACGGTGACCGTGGTCCCTTTGCCCCAGACGTCCATGTAGTAGTAGTAGTATCAGGGGCCCGGGGAATAGAAGCTGTGAGG
+
CC@FFFFFHHHHHJJJGIJGIFGHJFHJIIIFHJIIIJJJJJIJJJGIHHIIIHHGFECF@DDDFFCDDBEEEEEDDDBBDDBDD<>BDDDCDDDDAC@CD
@9MY
TCTCGAATTCCCGACCTCAGATGATCCACCCAACTCTGCCTCCCGAAGTGTTGGGATTACAGGCATAAGCCACTGCGCCCGGCCCTATTCCTTTATTGTTA
+
@@BDFFFFHHHHHJJJFIJIJIJJJJJJJJJJJJJIGIJJJJJJIJIJCFGIIBGHFGHHHFFF=CEECCCCCCCDBBBDDBBBBDCDDEEDCCDDCDED:
@9MZ
CGCCCGGCCCTATTCCTTTATTGTTATAAAATAATAATAATAATGTAATTAAGTAAATGGTCCTTCACCTCTCTGTTCAACCATTTTCCTACCCTTGATTT
+
CCCFFFFFHHHHHJJJJJJJJJIIIIJJJJIIIIIIJJIIJJIIJGHIIJIJJHIGIIIIFHIJIJJJGJIIJJHHGGGHHFFFFFEEEECE=BCDDCDD;
@9N0
TTTTTGGAAAAGTGTGGAGTTATTCCAAAGAAAACCTCCTATAGGTAATGTGTAAACATCGTGACCAGAAATCCTGGAGATCCACGAAGGCAACTACAAAG
+
CCCFFFFDHHHHDFBFHFHIJBHHIJJJJJJJJJJJJJJJIJJIJBDGGIGIIHIJJJJJJIJGIGIJJJHHHEHEEFFFFEEEEDDDDBBBDDDDDDDD9
@9N1
CCAAAGAAAACCTCCTATAGGTAATGTGTAAACATCGTGACCAGAAATCCTGGAGATCCACGAAGGCAACTACAAAGACTATGAAGGGAAACTACAGAAGT
+
@@@FFFFFFHFDDIJJIIIJICFHFGDHBBEHBEHGGGHJIICFHIGHEGGGHIIIIGEIGIGIIJ;?AHFFFE>@CCEECCCDD<CBBDDCDDDDDCDA#
@9N2
ACGAGGGGGAAAAGGGTTGGGGCGGATGCACTCCCTGAGGAGACGGTGACCGTGGTCCCTTTGCCCCAGACGTCCATGTAGTAGTAGTAGTATCAGGGGCC
+
@@CFDFD?FFFDHEEE:?FBAE<FBA39?5ACAABCC<?BCBA?B858+9@:0<<?:>A>>@@CCA<?BBBC(5<<B>CDDAADB>A:BD>B::3:>A<@<
@9N3
TCCACGAAGGCAACTACAAAGACTATGAAGGGAAACTACAGAAGTGGTTTTCTTAAAAAAATATACAGGCTATTTTTAGAGTGTTTTTAGGTTTAGAGCAA
+
?@+=DDDFHHHHHIJJIJJJJJJIJJJJJJJIGGGHIIJIJGHIFGIHJIGJJJIJJIEGEFFFFFFEEDEDDDDC@BDCD>@>CCC@BDDCCCC<CACDC
@9N4
AAAAGGGTTGGGGCGGATGCACTCCCTGAGGAGACGGTGACCGTGGTCCCTTTGCCCCAGACGTCCATGTAGTAGTAGTAGTATCAGGGGCCCGGGGAATA
+
@1?DDDDDHHHHF>GIDGIIBEF;C@=D;=CCD;?BB66;A@@8ABBCCBCCCC>>@B?<8258@<@DC(+:4>>+4:4+:4@DC@@CBB9>BBBBB95A4
@9N5
CAACTACAAAGACTATGAAGGGAAACTACAGAAGTGGTTTTCTTAAAAAAATATACAGGCTATTTTTAGAGTGTTTTTAGGTTTAGAGCAAAATTTGCAGA
+
8:?DDDD+ADDDDEIIIIDEEEFEIECEAEDDII>DD?DDCEIII>DIIDDDIIEEDEDDDIDD@DDDDAD?@DEAAA@>AAAAAAAAAA?A?AAA>>AAA
@9N6
AAGACTATGAAGGGAAACTACAGAAGTGGTTTTCTTAAAAAAATATACAGGCTATTTTTAGAGTGTTTTTAGGTTTAGAGCAAAATTTGCAGAAAGTACAG
+
@@@DFFFFFDHDHIIIIHGGGBGEHI9CECEGEHICCFFCGIJJJIJGIJEGJEGHGJGIIHIHC=AEEBB;CCE>ACCECDDACDDDCCECCCCD@ACC:
@9N7
CTATGAAGGGAAACTACAGAAGTGGTTTTCTTAAAAAAATATACAGGCTATTTTTAGAGTGTTTTTAGGTTTAGAGCAAAATTTGCAGAAAGTACAGAAAG
+
CCCFFFFFHHHHHJJIIJJGGIHHIHHIJJJJIIGJJJJJJJJJJIIJIIJIJJJJIIG@DGGGFHHGFCEFFFEEECCCCDDDDDDDCCDDDDDCDDDD:
@9N8
GGAAACTACAGAAGTGGTTTTCTTAAAAAAATATACAGGCTATTTTTAGAGTGTTTTTAGGTTTAGAGCAAAATTTGCAGAAAGTACAGAAAGTTCTTATA
+
@@?DDDDD>FH<3<<CAFAEHHIIH@FHB@FDEHCB<:BC;@BHHGHII@F8BCD;;CFGI=@@E=CAE:@@BDDCCC#######################
@9N9
CGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCCCAGTGCAAGCCAGGAAGAAGCCG
+
CCCFFFFFHHHHGJJJJJJJJJJJDGHJJJJGIIJIIIJJJHJJJBHEFHEEHFFEFEEEDEEECCDCCDDDB5@<ABB<ACCCDCDDDDBDBBBBDCC85
@9NA
CGGAGAACTGCCATTCTTTCCTGGGCATCCCGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAA
+
CCCFFFFFHHHHHJJJJJJJJJIIJJIJJJJJJJJJIJIJJIIIJJJJHHFFFDCCEEEDDDDBBDDBDCDDDDDDBDDDDDCCDDDDDCCCCDCC:@A>4
@9NB
CGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGAACTAGAAGGTGGCCCAGTGCAAGCCAGGAAGAAGCCG
+
@@CDDDFBFDFDFG@9FD6FHIGICHEGEHGGIIIDG1CDFGGGIDHHFH>AADBDBAACC;A(55;;;CCCD?:?@B<B?CACCCA@DCD(8<A?#####
@9NC
GGGAATTTTTGCTCCCTTCATGACGTGTGCGCCTGGTCCACTCCAGTCCTTCCCATGTGGACTCGTGGATCCAGCTCCAGCAGGAAACACTGGTTGTGATG
+
@@@DDDFFHHHGFIIJJIJJJJGHIDG>FHIIGEIFGGEGGHGG>FHHIGHIJJJGH=FGHIJIGEHEDFCCB:;>CEEDADDDDDDDDDC@A(:?@?@DC
@9ND
GCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCCCAGTGCAAGCCAGGAAGAAGCCGCGCCAAGAACCAG
+
CCCFFFFFHHHFHIIJJJIJJGIJIIIJJJIJIJJJJJJJIJJJJJJJJJJJJFIJJIHG=EHFFFCDCECCCCDBDDDDDDDDDD@BBDDDDDBDDDDD?
@9NE
CTTTCCTGGGCATCCCGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCCCAGTGCAA
+
@@@DDDDDFAHHH;FFIIGGGIBFD<FAD9?DGIIGDGHHCGG<AAAHBDDCAC@?CC=A7<ACC@ACCBCBCCCCDDC>C3>>@CA?9>((8<?B(:CC#
@9NF
CCAACAGGGACATGACAAGTTTTTATATCAGAACTACTATTTTTTACCTGTTTTATGTGGAAATCTGAGAGATGTGCCCAGCCTCAGGAGGCTAATTCTCC
+
@@@DFFEFGHFHGJJJJJJDHIIIGJIJJIGEHIIIICHIIIEHGHGGCBFEGHIGBHGIHIGCGIJJIGDCEEA77@BBBA?CCC(5;?;7?CCDDDA35
@9NG
CGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCCCAGTGCAAGCCAGGAAGAAGCCG
+
@C@FFDDFGFFDHIDGHEHGEGGIIIIGGGIJIGFGFDFH;A;F?EAEHHHHHFFBEDECEC>CCDCCC@CCBC>?BDD@DCCCAACBBD@B1<A(3>C##
@9NH
CGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCCCAGTGCAAGCCAGGAAGAAGCCG
+
@@@DFDFFGHGBDEHIGIGGIIIIBDEEGIHIGIIEGIGIFIIIIDC=HH7A>>BEFCCCA6>CCACCD(;;?::?BDADD4:@>:@BD9?12<?A?C?<0
@9NI
CTGCCATTCTTTCCTGGGCATCCCGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCC
+
CCCFFFFFHHHHHJIJJJJJJJJJIGIJGJJIJGIIJJJJIIJJGGHEHFFDFFFDDDDD@BCDDDDDDBDDD@CCDBCDDCCCCEDDDDCCCCDD>CBA?
@9NJ
CCCAGCCTCAGGAGGCTAATTCTCCATCCAGGGGACAGCACTAACAGAGTTATGTGGTATTAGTCTGTCTGGATCTTCATAAGAAGACAACAGGAGTGGGT
+
8?;DBDBDDHFBDH>EDEEEHHIIEBAACEGIF<0?B?8?F<FGBFCHDHIBGFFHG@CHHGIDGHIHHCHCE@C;@DBE6@A3>A9;?C?A9<A<<A@##
@9NK
CTGCCATTCTTTCCTGGGCATCCCGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCC
+
CCCFFFFDFHHFHJIEEGCHGHJJGIJGIIGGGGHGD;FEHJJJIGDAAEEFC;@BDCB??=C?C:?A??BCDEDCDDDDCCDA:AACDDCDCCC1+4<AA
@9NL
TCTCCATCCAGGGGACAGCACTAACAGAGTTATGTGGTATTAGTCTGTCTGGATCTTCATAAGAAGACAACAGGAGTGGGTGGCTTAAACAACAAATATTG
+
<@@FDEDDFBFFA>1CFHIIEGEIEAFCEFFEGHIIGDEDFHGDFGIIIIGFDFFACG<B<CF@7C>CCHGHGEFE;6;=,9;?AA>>ACC?AA9?:CCC:
@9NM
GCCATTCTTTCCTGGGCATCCCGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCCCA
+
CCCFFFFFHHHHHJJJJIJJJJIIJGIIIJJJGGIJJJJJIJJIFHHHHHFFFFDDDDBBDDDCDBD@@CDEDCCBDB?CCDDDDDDDDCCCCB>:?BDD8
@9NN
TGAATGTTGAAGATTAGTGTGCTGGCAGGGCTGGTTCTTGGCGCGGCTTCTTCCTGGCTTGCACTGGGCCACCTTCTAGTGCACTATGTCTCCACATGGCC
+
CCCFFFFFHHHHHJJIJIIHIJJJJCHJJJBGGIHGDHIGIGHEEHE>GCEE>C>)?;@B/;;A(-;=;<?BD9@##########################
@9NO
GCAGGGCTGGTTCTTGGCGCGGCTTCTTCCTGGCTTGCACTGGGCCACCTTCTAGTGCACTATGTCTCCACATGGCCTCTTCTCTGCCTGCTGGTACCTTG
+
CCCFFFFFHHHHHIIJIJJIJJJGJIGIGH4<DEHIFGHGGAGIAGFEH>DEEBB>@@@CECCC>;;ACCCDDAC?CCBCC>:3@:>>A:<C@A?AC@C##
@9NP
GTTGAAGATTAGTGTGCTGGCAGGGCTGGTTCTTGGCGCGGCTTCTTCCTGGCTTTCACTGGGCCCCCTTCTTGGGCACTATGTCTCCACATGGCCTCTTC
+
CBBFFFFFHHHHHIGIJJJJJJJJJGDBF:CDGGDHGH6DGA@E==D)7=;763@))7?3(;?######################################
@9NQ
GCCATTCTTTCCTGGGCATCCCGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAAGGTGGCCCA
+
CCCFFFDEHFBDFGHGHGHGGIGIIGIGIEHGHGCBFHEAHA@CEHFEA>CB;??A=;;A?CCA?B<59:>5>4@<9<?>CC:A:>A@>::>@1+4?A@B0
@9NR
CGGAGAACTGCCATTCTTTCCTGGGCATCCCGGGGATCCCAGAGCCGGCCCAGGTACCAGCAGGCAGAGAAGAGGCCATGTGGAGACATAGTGCACTAGAA
+
CCCFFFFFHHHHHJJJJJJJJJIIJJIJJJJJJJJJIJIJJIIIJJJJHHFFFDCCEEEDDDDBBDDBDCDDDDDDBDDDDDCCDDDDDCCCCDCC:@A>4
@9NS
TCTCCATCCAGGGGACAGCACTAACAGAGTTATGTGGTATTAGTCTGTCTGGATCTTCATAAGAAGACAACAGGAGTGGGTGGCTTAAACAACAAATATTG
+
<@@FDEDDFBFFA>1CFHIIEGEIEAFCEFFEGHIIGDEDFHGDFGIIIIGFDFFACG<B<CF@7C>CCHGHGEFE;6;=,9;?AA>>ACC?AA9?:CCC:
@9NT
GCAGGGCTGGTTCTTGGCGCGGCTTCTTCCTGGCTTGCACTGGGCCACCTTCTAGTGCACTATGTCTCCACATGGCCTCTTCTCTGCCTGCTGGTACCTTG
+
CCCFFFFFHHHHHIIJIJJIJJJGJIGIGH4<DEHIFGHGGAGIAGFEH>DEEBB>@@@CECCC>;;ACCCDDAC?CCBCC>:3@:>>A:<C@A?AC@C##
@9NU
CAGTGATCAATGTGATCAAGGCAGGTCATTTCTGCCCCCAAAGTGACACTCAGGCTTCTGCAGGGTGAGGATGTGTCCTCCTGCTGGTACCTGGGCCGGCT
+
@@CDDDDEHHHHHIJIEGEGHCFIJAFGGGHCBFHIIGIJJGGGII?<DHIJGBGHIGCCGGGGH@E?CHHFFFFFFEEEDECCCCC?CCC;ABD??9>>@
@9NV
TTTTTTTGTATATGTGCAGATGGGGTCTCAGTATGTTGCCCAGATTGGACTCTTGGCCTCAAGTGGTCCGCCTTGGCCTCCCCAAAGTGAGATTACAGGCA
+
CCCFFFFFCDFDHGGGHGGFHEGIJAHEGCG@DEDGF>>GIBF2DFFG>GHIJIGIDGIGEEHFGHHHHFFDDDDDDCDDDDDDDBDACCC>CCDDDDDD<
@9NW
GGAGGAGGTCTTGCCAGCAAAGCAGTAGTTGGGGTTGTAGTCGGTCATGATGGTCGAGGTGCGGAGCTTGCTCAGCTTGTACTCAGGGCTCTGCAGCTCCA
+
@C@FFFFFFHHHHJIJJJJJIJFCHFHHIIIIIJGHIGIJGIJJFHIIJJJJJJJJHHF@DFDDDDDDDDDDDDDDDCDDDEEDDDCDDDDDDDDDDDDDC
@9NX
CAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGAACGGTCAGTTTAGGGGCTGGTGCAAAGGATGAGTTGCACATTG
+
@CCFFFFFHHHHHJJJJIJJEFHJJJIIJGHJIIIIJJJJGIJJIJHEIIIJJJJCHHJJJJJGIHHHGIJIIHHFFFDFEE@E;ADCDDCCEDDDDDDDC
@9NY
GTTGAAGTGTGGTTCAGGGCCAGTGCATATTAGTGGACAGCACTTAGTAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGA
+
CCCFFFFFHHHHHJJJJJJJJJJIJJJJJJJJJIJJJJJJJJJJJJJIJJIIIIJJIJJJHHFFFEEDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD@
@9NZ
AGGATGAACCGGGGCAGGGATTGCAGGCTCACCCCAATGCAGCGAACAATGTTCTGGTGGTTGAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAG
+
??@DDFFFHFHHHIJJJJJIJGII@HIHIJIJJJJJJIJJIJCH=EFDEAEEDDEDDCCD?@BDCCCCDCCDCCCCDDEDCA?A?CDDEDDDDC<CC(:AC
@9O0
TGAAGTGTGGTTCAGGGCCAGTGCATATTAGTGGACAGCACTTAGTAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGC
+
CCCFFEFFHGHHHJJJJJJIJHIJJJJJJJJIGGIIGHJJJJJIIFIIGHIIIIJJJJIGGFF>AAAA@BDDDDDDDDDDDDDDDCDDDDC?CDDCACCDD
@9O1
CTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCATATTAGTGGACAGCACTTAGTAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGC
+
@@@DDDDDHAFBFAB:<B?CHHGAEHCEF1CCG@GGGGF:?;BFGCFHIIIICFFIFFFB:C;@BEED>/;A=AB;(,5<9:(:C>?@A:A>@:>@>@C<<
@9O2
GAATTTGCTGATGATCAGGGCTTCCATGAGGAAATCCAGTTCGTCCTGTTCAGAGCACACTTCAGGCAGCGTCTTCACAGCCACTTGCAGGGGGCTTGGGT
+
CCCFFFFFHHHHHJJJJJIJGIJJJJJJIJJIJHIJIJJHIJJJGHJFGHIJJJJIJIIIEIJJJJJJIJHHFFFDEEEEDDDDCCDDDDDDBBD><@BD8
@9O3
CCCCGTCCGGAGGAGCCGGGGCGGCGTAGGCGAAATCCCCGCGCGCCGGGGCAGGTTGGGAGACCCCCTCTGCCGGTGAGGTGGGGTCAGGGCCCCCTGC
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9O4
CCGCTATGCAGACATCTTTCCCTCCAAGGTTTGTCTGCAGTTGAAGATCCGTGAGGTGCGCCAGAAGATCATGCAGGCTGCCACTCCCACGGAGCAGCCC
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9O5
CCCTTGGCCCTGCGGCCCCGCTTGAGCGGGCCCAGGCTGTGCCACCGCGCAGGGGCCCGGCAGGCCGTCGCGCTGCGGGTCCCGGTCCTCCCGGCTTTTG
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9O6
GCTTCTTCCCGTCAGCCCAGGCCACAGCCGCCTTCCAGGCCCGCTATGCAGACATCTTTCCCTCCAAGGTTTGTCTGCAGTTGAAGATCCGTGAGGTGCG
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9O7
GGCGAAATCCCCGCGCGCCGGGGCAGGTTGGGAGACCCCCTCTGCCGGTGAGGTGGGGTCAGGGCCCCCTGCGGGGCTGGGAGTGGGGGCAGGGGCAGCA
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9O8
CCCCGTCCGGAGGAGCCGGGGCGGCGTAGGCGAAATCCCCGCGCGCCGGGGCAGGTTGGGAGACCCCCTCTGCCGGTGAGGTGGGGTCAGGGCCCCCTGC
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9O9
CCCGCTTGAGCGGGCCCAGGCTGTGCCACCGCGCAGGGGCCCGGCAGGCCGTCGCGCTGCGGGTCCCGGTCCTCCCGGCTTTTGCCCGGGTGCGGAGGCC
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9OA
GCTGTGCCACCGCGCAGGGGCCCGGCAGGCCGTCGCGCTGCGGGTCCCGGTCCTCCCGGCTTTTGCCCGGGTGCGGAGGCCACCGAGGAGCCTGAGGGTG
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9OB
GTGCGCCAGAAGATCATGCAGGCTGCCACTCCCACGGAGCAGCCCCCTGGAGCTGAGGCTCCTCTCCCTGTACCGCCCCCCACTGGCACCGCTGCTGCCC
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9OC
TTGCCCGGGTGCGGAGGCCACCGAGGAGCCTGAGGGTGGGAGAGCGCCCCGTCCGGAGGAGCCGGGGCGGCGTAGGCGAAATCCCCGCGCGCCGGGGCAG
+
IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII
@9OD
AGCTGTGTTTAGAAAATTCTCAGTCCAGCACTATTCATAATAGCAAAGACATTAACCCAGGTTGGGTAAATAAATGATGACACAGGCTTCCCCCATACGGT
+
CCCFFFFFHHHHHJJIJJGJJJJIJJJJIJJJIJJJJJJJJIJJJJJJJJJJJJJJJJJIJGHGJJGHIJIJIHHEFHHFFFFFFDDCE?CDDDDDDDDDC
@9OE
CACTATTCATAATAGCAAAGACATTAACCCAGGTTGGGTAAATAAATGATGACACAGGCTTCCCCCATACGGTGACTACAGCCAACCCTGAGGGATCGCAG
+
@@@DD?BDHFDHDEEHGGGFFHHIIGEIIGIIG??CDF6?BGGEGECCGCGDDHIEAGE;=8.@F@EH9?;17;;?;@@;(.;5=B8?9<?35?#######
@9OF
CAGCACTATTCATAATAGCAAAGACATTAACCCAGGTTGGGTAAATAAATGATGACACAGGCTTCCCCCATACGGTGACTACAGCCAACCCTGAGGGATCG
+
CCCFFFFFHHHHHJIJJJJJJJIJIJJJIJIJJJJJGIIJJHHHIIJJIIIIJJIIJJJJJJIJGHHJJBHHFFFEBCEEEDDDDDDDBDDBDDDDDBDDD
@9OG
CAGCACTATTCATAATAGCAAAGACATTAACCCAGGTTGGGTAAATAAATGATGACACAGGCTTCCCCCATACGGTGACTACAGCCAACCCTGAGGGATCG
+
@CCFFDAEHGHFDHIJIJJJIJIJJJJJJJJIJIJJ:?FEH?BFHGHDGHIGAGGIIIFHJI<@GEICHACE@D7?A;A>ACCC>AA;?=;959<BB5<B5
@9OH
CCAGCACTATTCATAATAGCAAAGACATTAACCCAGGTTGGGTAAATAAATGATGACACAGGCTTCCCCCATACGGTGACTACAGCCAACCCTGAGGGATC
+
CCCFFFFFHHHHHJJJJIJJJIJJJHIIJJJHJJJJJFHIJJFHIJJJJIJIIIIGIIJJIIGIJGHHIHBEFEFB@BCEDEDD>CD=C@BBACDDBDBC?