|
|
|
|
|
|
|
|
disk_size=disk_size |
|
|
disk_size=disk_size |
|
|
} |
|
|
} |
|
|
} |
|
|
} |
|
|
else { |
|
|
|
|
|
# Fastq is null, check if starts with vcf |
|
|
|
|
|
if (!defined(vcf_D5) && !defined(vcf_D6) && !defined(vcf_F7) && !defined(vcf_M8) ) { |
|
|
|
|
|
call rename_vcf.rename_vcf as rename_vcf{ |
|
|
|
|
|
input: |
|
|
|
|
|
vcf_D5=vcf_D5, |
|
|
|
|
|
vcf_D6=vcf_D6, |
|
|
|
|
|
vcf_F7=vcf_F7, |
|
|
|
|
|
vcf_M8=vcf_M8, |
|
|
|
|
|
project=project, |
|
|
|
|
|
docker=DIYdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
call filter_vcf.filter_vcf as filter_vcf_D5_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
vcf=rename_vcf.vcf_D5_renamed, |
|
|
|
|
|
docker=BEDTOOLSdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call benchmark.benchmark as benchmark_D5_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
filtered_vcf=filter_vcf_D5_vcf.filtered_vcf, |
|
|
|
|
|
benchmarking_dir=benchmarking_dir, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call filter_vcf.filter_vcf as filter_vcf_D6_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
vcf=rename_vcf.vcf_D6_renamed, |
|
|
|
|
|
docker=BEDTOOLSdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call benchmark.benchmark as benchmark_D6_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
filtered_vcf=filter_vcf_D6_vcf.filtered_vcf, |
|
|
|
|
|
benchmarking_dir=benchmarking_dir, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call filter_vcf.filter_vcf as filter_vcf_F7_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
vcf=rename_vcf.vcf_F7_renamed, |
|
|
|
|
|
docker=BEDTOOLSdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call benchmark.benchmark as benchmark_F7_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
filtered_vcf=filter_vcf_F7_vcf.filtered_vcf, |
|
|
|
|
|
benchmarking_dir=benchmarking_dir, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call filter_vcf.filter_vcf as filter_vcf_M8_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
vcf=rename_vcf.vcf_M8_renamed, |
|
|
|
|
|
docker=BEDTOOLSdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call benchmark.benchmark as benchmark_M8_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
filtered_vcf=filter_vcf_M8_vcf.filtered_vcf, |
|
|
|
|
|
benchmarking_dir=benchmarking_dir, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
Array[File] benchmark_summary_hap = [benchmark_D5_vcf.summary, benchmark_D6_vcf.summary, benchmark_F7_vcf.summary, benchmark_M8_vcf.summary] |
|
|
|
|
|
|
|
|
|
|
|
call multiqc_hap.multiqc_hap as multiqc_hap { |
|
|
|
|
|
input: |
|
|
|
|
|
summary=benchmark_summary_hap, |
|
|
|
|
|
docker=MULTIQCdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call extract_tables_vcf.extract_tables_vcf as extract_tables_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
hap=multiqc_hap.hap, |
|
|
|
|
|
project=project, |
|
|
|
|
|
docker=DIYdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call merge_family.merge_family as merge_family_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
D5_vcf=benchmark_D5_vcf.rtg_vcf, |
|
|
|
|
|
D6_vcf=benchmark_D6_vcf.rtg_vcf, |
|
|
|
|
|
F7_vcf=benchmark_F7_vcf.rtg_vcf, |
|
|
|
|
|
M8_vcf=benchmark_M8_vcf.rtg_vcf, |
|
|
|
|
|
D5_vcf_tbi=benchmark_D5_vcf.rtg_vcf_index, |
|
|
|
|
|
D6_vcf_tbi=benchmark_D6_vcf.rtg_vcf_index, |
|
|
|
|
|
F7_vcf_tbi=benchmark_F7_vcf.rtg_vcf_index, |
|
|
|
|
|
M8_vcf_tbi=benchmark_M8_vcf.rtg_vcf_index, |
|
|
|
|
|
project=project, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size, |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call mendelian.mendelian as mendelian_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
family_vcf=merge_family_vcf.family_vcf, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=MENDELIANdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call merge_mendelian.merge_mendelian as merge_mendelian_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
D5_trio_vcf=mendelian_vcf.D5_trio_vcf, |
|
|
|
|
|
D6_trio_vcf=mendelian_vcf.D6_trio_vcf, |
|
|
|
|
|
family_vcf=merge_family_vcf.family_vcf, |
|
|
|
|
|
docker=DIYdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
# Fastq is null, check if starts with vcf |
|
|
|
|
|
if (!defined(vcf_D5) && !defined(vcf_D6) && !defined(vcf_F7) && !defined(vcf_M8) ) { |
|
|
|
|
|
call rename_vcf.rename_vcf as rename_vcf{ |
|
|
|
|
|
input: |
|
|
|
|
|
vcf_D5=vcf_D5, |
|
|
|
|
|
vcf_D6=vcf_D6, |
|
|
|
|
|
vcf_F7=vcf_F7, |
|
|
|
|
|
vcf_M8=vcf_M8, |
|
|
|
|
|
project=project, |
|
|
|
|
|
docker=DIYdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
call filter_vcf.filter_vcf as filter_vcf_D5_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
vcf=rename_vcf.vcf_D5_renamed, |
|
|
|
|
|
docker=BEDTOOLSdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call benchmark.benchmark as benchmark_D5_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
filtered_vcf=filter_vcf_D5_vcf.filtered_vcf, |
|
|
|
|
|
benchmarking_dir=benchmarking_dir, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call filter_vcf.filter_vcf as filter_vcf_D6_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
vcf=rename_vcf.vcf_D6_renamed, |
|
|
|
|
|
docker=BEDTOOLSdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call benchmark.benchmark as benchmark_D6_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
filtered_vcf=filter_vcf_D6_vcf.filtered_vcf, |
|
|
|
|
|
benchmarking_dir=benchmarking_dir, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call filter_vcf.filter_vcf as filter_vcf_F7_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
vcf=rename_vcf.vcf_F7_renamed, |
|
|
|
|
|
docker=BEDTOOLSdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call benchmark.benchmark as benchmark_F7_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
filtered_vcf=filter_vcf_F7_vcf.filtered_vcf, |
|
|
|
|
|
benchmarking_dir=benchmarking_dir, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call filter_vcf.filter_vcf as filter_vcf_M8_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
vcf=rename_vcf.vcf_M8_renamed, |
|
|
|
|
|
docker=BEDTOOLSdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call benchmark.benchmark as benchmark_M8_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
filtered_vcf=filter_vcf_M8_vcf.filtered_vcf, |
|
|
|
|
|
benchmarking_dir=benchmarking_dir, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
Array[File] benchmark_summary_hap = [benchmark_D5_vcf.summary, benchmark_D6_vcf.summary, benchmark_F7_vcf.summary, benchmark_M8_vcf.summary] |
|
|
|
|
|
|
|
|
|
|
|
call multiqc_hap.multiqc_hap as multiqc_hap { |
|
|
|
|
|
input: |
|
|
|
|
|
summary=benchmark_summary_hap, |
|
|
|
|
|
docker=MULTIQCdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call extract_tables_vcf.extract_tables_vcf as extract_tables_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
hap=multiqc_hap.hap, |
|
|
|
|
|
project=project, |
|
|
|
|
|
docker=DIYdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call merge_family.merge_family as merge_family_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
D5_vcf=benchmark_D5_vcf.rtg_vcf, |
|
|
|
|
|
D6_vcf=benchmark_D6_vcf.rtg_vcf, |
|
|
|
|
|
F7_vcf=benchmark_F7_vcf.rtg_vcf, |
|
|
|
|
|
M8_vcf=benchmark_M8_vcf.rtg_vcf, |
|
|
|
|
|
D5_vcf_tbi=benchmark_D5_vcf.rtg_vcf_index, |
|
|
|
|
|
D6_vcf_tbi=benchmark_D6_vcf.rtg_vcf_index, |
|
|
|
|
|
F7_vcf_tbi=benchmark_F7_vcf.rtg_vcf_index, |
|
|
|
|
|
M8_vcf_tbi=benchmark_M8_vcf.rtg_vcf_index, |
|
|
|
|
|
project=project, |
|
|
|
|
|
docker=BENCHMARKdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size, |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call mendelian.mendelian as mendelian_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
family_vcf=merge_family_vcf.family_vcf, |
|
|
|
|
|
ref_dir=ref_dir, |
|
|
|
|
|
fasta=fasta, |
|
|
|
|
|
docker=MENDELIANdocker, |
|
|
|
|
|
cluster_config=BIGcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
|
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
call merge_mendelian.merge_mendelian as merge_mendelian_vcf { |
|
|
|
|
|
input: |
|
|
|
|
|
D5_trio_vcf=mendelian_vcf.D5_trio_vcf, |
|
|
|
|
|
D6_trio_vcf=mendelian_vcf.D6_trio_vcf, |
|
|
|
|
|
family_vcf=merge_family_vcf.family_vcf, |
|
|
|
|
|
docker=DIYdocker, |
|
|
|
|
|
cluster_config=SMALLcluster_config, |
|
|
|
|
|
disk_size=disk_size |
|
|
} |
|
|
} |
|
|
} |
|
|
} |
|
|
|
|
|
|
|
|
} |
|
|
} |
|
|
|
|
|
|
|
|
|
|
|
|