task mendelian { File family_vcf File ref_dir String family_name = basename(family_vcf,".family.vcf") String fasta String docker String cluster_config String disk_size command <<< export LD_LIBRARY_PATH=/opt/htslib-1.9 nt=$(nproc) echo -e "${family_name}\tLCL8\t0\t0\t2\t-9\n${family_name}\tLCL7\t0\t0\t1\t-9\n${family_name}\tLCL5\tLCL7\tLCL8\t2\t-9" > ${family_name}.D5.ped mkdir VBT_D5 /opt/VBT-TrioAnalysis/vbt mendelian -ref ${ref_dir}/${fasta} -mother ${family_vcf} -father ${family_vcf} -child ${family_vcf} -pedigree ${family_name}.D5.ped -outDir VBT_D5 -out-prefix ${family_name}.D5 --output-violation-regions -thread-count $nt cat VBT_D5/${family_name}.D5_trio.vcf > ${family_name}.D5.vcf echo -e "${family_name}\tLCL8\t0\t0\t2\t-9\n${family_name}\tLCL7\t0\t0\t1\t-9\n${family_name}\tLCL6\tLCL7\tLCL8\t2\t-9" > ${family_name}.D6.ped mkdir VBT_D6 /opt/VBT-TrioAnalysis/vbt mendelian -ref ${ref_dir}/${fasta} -mother ${family_vcf} -father ${family_vcf} -child ${family_vcf} -pedigree ${family_name}.D6.ped -outDir VBT_D6 -out-prefix ${family_name}.D6 --output-violation-regions -thread-count $nt cat VBT_D6/${family_name}.D6_trio.vcf > ${family_name}.D6.vcf >>> runtime { docker:docker cluster: cluster_config systemDisk: "cloud_ssd 40" dataDisk: "cloud_ssd " + disk_size + " /cromwell_root/" } output { File D5_ped = "${family_name}.D5.ped" File D6_ped = "${family_name}.D6.ped" Array[File] D5_mendelian = glob("VBT_D5/*") Array[File] D6_mendelian = glob("VBT_D6/*") File D5_trio_vcf = "${family_name}.D5.vcf" File D6_trio_vcf = "${family_name}.D6.vcf" } }